avian myeloblastosis virus

Summary

Summary: A species of ALPHARETROVIRUS causing anemia in fowl.

Top Publications

  1. pmc Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro
    J D Roberts
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Mol Cell Biol 9:469-76. 1989
  2. ncbi Kinetics of deoxyribonucleotide insertion and extension at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase
    H Cai
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340
    J Biol Chem 268:23567-72. 1993
  3. ncbi High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus
    D J Schneider
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA
    Biochemistry 34:9599-610. 1995
  4. ncbi Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene
    M Introna
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 63:1289-97. 1990
  5. ncbi Transformation by v-Myb
    J S Lipsick
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Oncogene 18:3047-55. 1999
  6. ncbi Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and Moloney murine leukaemia virus
    Kiyoshi Yasukawa
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biochem 143:261-8. 2008
  7. pmc Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells
    J Soret
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    J Virol 63:1803-7. 1989
  8. ncbi Pathogenic potential of myeloblastosis-associated viruses
    B Perbal
    UFR de Biochimie, Université Paris 7 D Diderot, France
    Infect Agents Dis 4:212-27. 1995
  9. pmc Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases
    J J DeStefano
    Department of Microbiology, University of Maryland, College Park 20742
    Nucleic Acids Res 22:3793-800. 1994
  10. ncbi Pathogenic potential of myeloblastosis-associated virus: implication of env proteins for osteopetrosis induction
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Virology 195:812-9. 1993

Research Grants

  1. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
  2. Function of the Drosophila Myb Proto-Oncogene
    Joseph Lipsick; Fiscal Year: 2005
  3. TUMOR INDUCTION BY AVIAN MYELOBLASTOSIS VIRUS
    MARCEL BALUDA; Fiscal Year: 1993
  4. TRANSFORMATION BY THE MYB ONCOGENE
    Joseph Lipsick; Fiscal Year: 1993
  5. VIRUS INDUCED MYELOID LEUKEMIA
    David Boettiger; Fiscal Year: 1990

Scientific Experts

Detail Information

Publications157 found, 100 shown here

  1. pmc Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro
    J D Roberts
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Mol Cell Biol 9:469-76. 1989
    We determined the fidelity of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases (RTs) during DNA synthesis in vitro using the M13mp2 lacZ alpha gene as a mutational target...
  2. ncbi Kinetics of deoxyribonucleotide insertion and extension at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase
    H Cai
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340
    J Biol Chem 268:23567-72. 1993
    ..A striking result was that while primers were extended past an abasic lesion by HIV-1 RT in both direct and misalignment modes, avian myeloblastosis virus RT failed to catalyze significant extension by either mode.
  3. ncbi High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus
    D J Schneider
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA
    Biochemistry 34:9599-610. 1995
    ..These ssDNA molecules may be useful as inhibitors or as models for the design of small molecule inhibitors of HIV-1 RT in vivo...
  4. ncbi Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene
    M Introna
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 63:1289-97. 1990
    ..These results indicate that different forms of v-myb impose alternate phenotypes of differentiation on transformed myeloid cells, probably by regulating unique sets of differentiation-specific genes...
  5. ncbi Transformation by v-Myb
    J S Lipsick
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Oncogene 18:3047-55. 1999
    The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia in animals and transforms only hematopoietic cells in culture...
  6. ncbi Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and Moloney murine leukaemia virus
    Kiyoshi Yasukawa
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biochem 143:261-8. 2008
    Reverse transcriptases (RTs) from avian myeloblastosis virus (AMV) and Moloney murine leukaemia virus (MMLV) have been most extensively used as a tool for conversion of RNA to DNA...
  7. pmc Induction of nephroblastoma by myeloblastosis-associated virus type 1: state of proviral DNAs in tumor cells
    J Soret
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    J Virol 63:1803-7. 1989
    ..Rearrangements occur preferentially in the gag-pol region of the MAV1 proviral genome, and similar rearrangements can be detected in well-developed independent tumors...
  8. ncbi Pathogenic potential of myeloblastosis-associated viruses
    B Perbal
    UFR de Biochimie, Université Paris 7 D Diderot, France
    Infect Agents Dis 4:212-27. 1995
    ....
  9. pmc Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases
    J J DeStefano
    Department of Microbiology, University of Maryland, College Park 20742
    Nucleic Acids Res 22:3793-800. 1994
    ..extent of RNA cleavage carried out during DNA synthesis by either human immunodeficiency virus (HIV) or avian myeloblastosis virus (AMV) reverse transcriptases (RTs)...
  10. ncbi Pathogenic potential of myeloblastosis-associated virus: implication of env proteins for osteopetrosis induction
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Virology 195:812-9. 1993
    ..These results, together with sequence comparisons between the MAV strains examined, suggest that subtle changes in the primary structure of the TM env protein's extracellular domain are likely to affect the tumorigenic potential of MAV...
  11. ncbi Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases
    J Tozser
    Department of Biochemistry, University Medical School of Debrecen, H 4012 Debrecen, Hungary
    J Biol Chem 271:6781-8. 1996
    ..Here a similar approach is used to characterize the specificity of avian myeloblastosis virus (AMV) PR and to compare it with those of the previously characterized lentiviral PRs...
  12. ncbi Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates
    H Yu
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340
    J Biol Chem 267:10888-96. 1992
    A comparison of the fidelity of reverse transcriptases (RT) from human immunodeficiency virus (HIV-1) and avian myeloblastosis virus (AMV) is made using RNA and DNA primer-template molecules in vitro...
  13. pmc Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases
    G M Fuentes
    Department of Microbiology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Nucleic Acids Res 24:1719-26. 1996
    ..This suggests that degradation of downstream pieces of RNA is not absolutely required before synthesis of the plus strand DNA. The implications of these findings for viral replication are discussed...
  14. pmc The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain
    K H Klempnauer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, FRG
    EMBO J 6:2719-25. 1987
    ..This region has been highly conserved between myb genes of different species. Our results are therefore consistent with the hypothesis that DNA-binding is an important aspect of myb protein function...
  15. pmc Characterization of the v-myb DNA binding domain
    T Oehler
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, FRG
    Nucleic Acids Res 18:1703-10. 1990
    ..Our results support the view that specific sequence-recognition, mediated by the conserved myb repeats, is a general feature of myb-related proteins...
  16. pmc Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    EMBO J 12:2027-38. 1993
    ..Our results suggest a role for C/EBP beta, and possibly for other C/EBP transcription factors, in v-myb function and in myeloid-specific gene activation...
  17. pmc tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    EMBO J 16:1371-80. 1997
    ..Together with previous work our results suggest that C/EBP may be a general cooperation partner for v-Myb in myelomonocytic cells...
  18. ncbi The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
    S A Ness
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 59:1115-25. 1989
    ..We conclude that mim-1 is a cellular gene that is directly regulated by the product of the v-myb oncogene...
  19. ncbi Oncogenic point mutations induce altered conformation, redox sensitivity, and DNA binding in the minimal DNA binding domain of avian myeloblastosis virus v-Myb
    E M Brendeford
    Department of Biochemistry, University of Oslo, N 0316 Oslo 3, Norway
    J Biol Chem 272:4436-43. 1997
    ..Activated oncogenic forms of Myb are encoded by the avian retroviruses, avian myeloblastosis virus (AMV) and E26. AMV v-Myb encodes a truncated protein with 11 point mutations relative to c-Myb...
  20. ncbi Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides
    Giovanni Romeo
    Dipartimento Farmaco Chimico, Universita di Messina, Via SS Annunziata, Messina 98168, Italy
    Bioorg Med Chem 14:3818-24. 2006
    ....
  21. ncbi CBP sensitizes v-myb-transformed monoblasts to differentiation inducers
    Jana Smardova
    Department of Pathology and Anatomy, University Hospital, Jihlavska 20, 625 00 Brno, Czech Republic
    Differentiation 73:222-32. 2005
    ..These results indicate that cellular context is an important factor determining whether CBP will activate or suppress the protein it targets...
  22. pmc Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites
    Peter Bagossi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Virol 79:4213-8. 2005
    ..Specificities at this position were compared for HIV-1, HIV-2, equine infectious anemia virus, avian myeloblastosis virus, Mason-Pfizer monkey virus, mouse mammary tumor virus, Moloney murine leukemia virus, human T-cell ..
  23. pmc Avian myeoloblastosis virus (AMV): only one side of the coin
    Bernard Perbal
    Department of Dermatology, University of Michigan Medical School, 1150 W, Medical Center Dr, Medical Science I, Room 6447, Ann Arbor, Michigan 48109 0609, USA
    Retrovirology 5:49. 2008
    ....
  24. ncbi Novel FRET-based assay to detect reverse transcriptase activity using modified dUTP analogues
    Joseph F Krebs
    Ambion Applied Biosystems, Research and Development Department, 2130 Woodward Austin, Texas 78744, USA
    Bioconjug Chem 19:185-91. 2008
    ..Our results indicate that the wild-type AMV (avian myeloblastosis virus) enzyme is slightly more stable at 43 degrees C than the HIV-1 (human immunodeficiency virus) or MMLV (..
  25. ncbi Evidence for virus closely related to avian myeloblastosis-associated virus type 1 in a commercial stock of chickens
    J Lloyd Spencer
    Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, Animal Diseases Research Institute, 3851 Fallowfield Road, Ottawa, Ontario, Canada K2H 8P9
    Avian Pathol 32:383-90. 2003
    ....
  26. ncbi A chimeric plum pox virus shows reduced spread and cannot compete with its parental wild-type viruses in a mixed infection
    Christof Dietrich
    German Collection of Microorganisms and Cell Cultures, Plant Virus Division, Inhoffenstr 7B, 38124 Braunschweig, Germany
    J Gen Virol 88:2846-51. 2007
    ..These data suggest that, in PPV infections, symptom severity and competitiveness are independent aspects and that spatial separation may contribute to the displacement of a recombinant virus...
  27. ncbi Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene
    K H Klempnauer
    Cell 31:453-63. 1982
    The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons)...
  28. pmc Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus
    D G Bergmann
    J Virol 40:450-5. 1981
    b>Avian myeloblastosis virus contains a continuous sequence of approximately 1,000 nucleotides which may represent a gene (amv) responsible for acute myeloblastic leukemia in chickens...
  29. ncbi Nucleotide sequence of chicken c-myb complementary DNA and implications for myb oncogene activation
    D Rosson
    Nature 319:604-6. 1986
    b>Avian myeloblastosis virus (AMV), like other acute transforming viruses, arose by recombination between its helper virus and host cellular sequences...
  30. ncbi Identification of potential human oncogenes by mapping the common viral integration sites in avian nephroblastoma
    Petr Pajer
    Institute of Molecular Genetics AS CR, Prague, Czech Republic
    Cancer Res 66:78-86. 2006
    ..Thus, the avian nephroblastoma is a valid source of cancer-associated genes. Moreover, the results bring deeper insight into the molecular background of tumorigenesis in distant species...
  31. ncbi Effects of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis on HIV-1 reverse transcriptase
    Helena de Souza Pereira
    Departamento de Biologia Celular e Molecular Programa de Neuroimunologia, Instituto de Biologia, Universidade Federal Fluminense, Niteroi RJ, Brasil
    Planta Med 71:1019-24. 2005
    ..The kinetic behavior analyses of the HIV-1 RT demonstrate that both diterpenes have similar mechanisms of inhibition of RDDP activity...
  32. pmc Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences
    S Lavu
    Nucleic Acids Res 14:5309-20. 1986
    ..such a viral insertion interrupts the c-myb coding region at a region identical to that observed in the generation of the v-myb gene of avian myeloblastosis virus and results in the synthesis of mRNAs that lack the same 5' coding region.
  33. pmc Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript
    D Westaway
    EMBO J 5:301-9. 1986
    ..Little or no increase in c-Ha-ras RNA or protein was observed in other nephroblastomas...
  34. ncbi A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts
    Eva Ondrousková
    Department of Genetics and Molecular Biology, Faculty of Science, Masaryk University, ILBIT, Pavilon A3, Kamenice 5, 625 00 Brno, Czech Republic
    Leuk Res 31:221-9. 2007
    v-myb oncogene of avian myeloblastosis virus (AMV) transforms myelomonocytic cells in vitro and induces acute monoblastic leukemia in vivo...
  35. pmc Protein truncation is required for the activation of the c-myb proto-oncogene
    F A Grasser
    Institut fur Medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Universitatskliniken des Saarlandes, Homburg, Germany
    Mol Cell Biol 11:3987-96. 1991
    The protein product of the v-myb oncogene of avian myeloblastosis virus, v-Myb, differs from its normal cellular counterpart, c-Myb, by (i) expression under the control of a strong viral long terminal repeat, (ii) truncation of both its ..
  36. pmc The role of template-primer in protection of reverse transcriptase from thermal inactivation
    Gary F Gerard
    Invitrogen Corporation, 7335 Executive Way, Frederick, MD 21704, USA
    Nucleic Acids Res 30:3118-29. 2002
    We compared the thermal stabilities of wild-type recombinant avian myeloblastosis virus (AMV) and Moloney murine leukemia virus (M-MLV) reverse transcriptase (RT) with those of mutants of the recombinant enzymes lacking RNase H activity...
  37. pmc Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 35:6846-53. 2007
    ..containing an abasic (rAS) site and used it as a template for studying DNA primer extension by HIV-1, avian myeloblastosis virus (AMV) and moloney murine leukemia virus (MMLV) reversed transcriptases (RT)...
  38. ncbi E26 leukemia virus converts primitive erythroid cells into cycling multilineage progenitors
    Kelly M McNagny
    Biomedical Research Centre, Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Blood 101:1103-10. 2003
    ..These results suggest that the Myb-Ets oncoprotein of the E26 leukemia virus converts primitive erythroid cells into proliferating definitive-type multipotent hematopoietic progenitors...
  39. ncbi Characterization, sequence, and expression of the cloned human neuropeptide Y gene
    C D Minth
    J Biol Chem 261:11974-9. 1986
    ..by primer extension analysis using a primer derived from a human cDNA, pheochromocytoma RNA and avian myeloblastosis virus reverse transcriptase...
  40. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    ..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
  41. ncbi cDNA cloning of a homeobox-containing gene expressed in avian myeloblastic virus-transformed chicken monoblastic leukaemia cells
    M R Crompton
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Leukemia 5:357-60. 1991
    ..polymerase chain reaction and differential library screening, a cDNA for an mRNA expressed in chicken avian myeloblastosis virus (AMV)-transformed monoblasts was isolated...
  42. pmc Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas
    V Joliot
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Centre Universitaire, Orsay, France
    Mol Cell Biol 12:10-21. 1992
    ..We also showed that the expression of an amino-terminal-truncated nov product in chicken embryo fibroblasts was sufficient to induce their transformation...
  43. ncbi Identification of genes differentially expressed in two types of v-myb-transformed avian myelomonocytic cells
    T Nakano
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Oncogene 7:527-34. 1992
    ..forms of the v-myb oncogene transform myeloid cells which resemble either monoblasts [when v-myb of avian myeloblastosis virus (AMV) was used] or promyelocytes [when a point mutant in v-myb of AMV was used; Introna, M., Golay, J...
  44. ncbi SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase
    Jay P Powers
    Amgen Inc, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
    J Med Chem 49:1034-46. 2006
    ..Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b...
  45. pmc Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells
    M R Crompton
    Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Nucleic Acids Res 20:5661-7. 1992
    ..Human and murine Prh homologues have also been identified; so it is likely that such genes are a general feature of vertebrate genomes...
  46. ncbi Expression of a recombinant gag protein from endogenous avian virus and its use in screening for antibody reactivity in recipients of chick-derived vaccines
    Jeffrey A Johnson
    HIV and Retrovirology Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Vaccine 21:3738-45. 2003
    ..9% amino acid identity to avian myeloblastosis virus (AMV) p27 capsid...
  47. ncbi Influence of template primary and secondary structure on the rate and fidelity of DNA synthesis
    G G Hillebrand
    J Biol Chem 260:3116-25. 1985
    ..of Escherichia coli), T4 polymerase (encoded by bacteriophage T4), and AMV polymerase (DNA polymerase of avian myeloblastosis virus]...
  48. ncbi Studies of the human c-myb gene and its product in human acute leukemias
    D J Slamon
    Science 233:347-51. 1986
    The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution...
  49. pmc Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site
    Helga Eizert
    University of Debrecen, Department of Biochemistry and Molecular Biology, Nagyerdei krt 98, Debrecen H 4012, Hungary
    J Virol 82:10111-7. 2008
    ..Our enzyme set comprised the proteases of HIV-1, HIV-2, equine infectious anemia virus, avian myeloblastosis virus (AMV), Mason-Pfizer monkey virus, mouse mammary tumor virus (MMTV), Moloney murine leukemia virus, human ..
  50. pmc The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication
    Holger Gundelach
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str, 2, D 48149 Munster, Germany
    BMC Mol Biol 8:75. 2007
    ..a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV)...
  51. ncbi 6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella Universitaria SS554, 09142 Monserrato Cagliari, Italy
    Antiviral Res 65:117-24. 2005
    ..RNA-dependent DNA polymerase (RDDP) activity and on the RNase H activities displayed by the Avian Myeloblastosis Virus and E. coli...
  52. pmc Poly(A) RNA in Escherichia coli: nucleotide sequence at the junction of the lpp transcript and the polyadenylate moiety
    G J Cao
    Department of Metabolic Regulation, Boston Biomedical Research Institute, MA 02114
    Proc Natl Acad Sci U S A 89:7546-50. 1992
    ..synthesized DNA complementary to polyadenylylated lipoprotein mRNA, encoded by the lpp gene, by using avian myeloblastosis virus reverse transcriptase and an oligo(dT)-containing primer...
  53. pmc Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates
    Y Gong
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    BMC Microbiol 1:12. 2001
    ..The mechanism of this template commitment is unknown. Here we provide evidence that the RNAseH activity of duck hepatitis B virus reverse transcriptase may also be unable to act on exogenous substrates...
  54. ncbi Immunoblotting with polyclonal and monoclonal antibody to avian myeloblastosis protein p27: studies of liver proteins in chickens with erythroblastosis
    C L Darcel
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Vet Res Commun 11:583-8. 1987
    An antigen detected by complement fixation with polyclonal antibody to avian myeloblastosis virus (AMV) antigen p27, appears in the livers of chickens inoculated with avian erythroblastosis virus (AEV)...
  55. ncbi Effects of organic solvents on the reverse transcription reaction catalyzed by reverse transcriptases from avian myeloblastosis virus and Moloney murine leukemia virus
    Kiyoshi Yasukawa
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Biosci Biotechnol Biochem 74:1925-30. 2010
    ..and glycerol on the reverse transcription reaction catalyzed by reverse transcriptases (RTs) from avian myeloblastosis virus (AMV) and Moloney murine leukemia virus (MMLV)...
  56. ncbi v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells
    L Knopfova
    Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Neoplasma 55:286-93. 2008
    ..In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of avian myeloblastosis virus in U937 cells...
  57. ncbi Terminal deoxynucleotidyl transferase. catalysis of DNA (oligodeoxynucleotide) phosphorylation
    A A Krayevsky
    Department of Chemical and Biological Analysis, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str, Moscow, Russia
    Pharmacol Ther 85:165-73. 2000
    ..The reaction is specific for TDT, and it is not catalyzed by avian myeloblastosis virus reverse transcriptase...
  58. ncbi Biological properties of streptonigrin derivatives. III. In vitro and in vivo antiviral and antitumor activities
    Y Take
    Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan
    J Antibiot (Tokyo) 42:968-76. 1989
    Antitumor antibiotic streptonigrin (STN-COOH) is a potent inhibitor of avian myeloblastosis virus (AMV) and human immunodeficiency virus reverse transcriptases...
  59. ncbi Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor
    I Katoh
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research, Ibaraki, Japan
    Nature 329:654-6. 1987
    ..The primary structure has so far been determined for the protease of avian myeloblastosis virus, and of murine, feline and bovine leukaemia viruses...
  60. ncbi Differential regulation of c-Myb-induced transcription activation by a phosphorylation site in the negative regulatory domain
    M R Miglarese
    Departments of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:22697-705. 1996
    ..Two acute transforming retroviruses, avian myeloblastosis virus and the E26 leukemia virus, transduced portions of c-myb and encode Myb proteins that are truncated in ..
  61. ncbi The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation
    E Kowenz-Leutz
    Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Cell 91:185-95. 1997
    The homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV)...
  62. pmc The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26
    M F Nunn
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138 9216
    J Virol 63:398-402. 1989
    ..myb sequences are also present in avian myeloblastosis virus, which transforms myeloblasts exclusively...
  63. pmc Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 283:30540-8. 2008
    ..In contrast to c-Myb, the v-myb gene product (v-Myb) encoded by the avian myeloblastosis virus was resistant to NLK/Fbxw7alpha-induced degradation...
  64. ncbi The deoxyribo-mode expression of primase activities of the primase-alpha DNA polymerase enzyme complex associated with nucleoprotein complexes harboring an extrachromosomal DNA identical with avian myeloblastosis virus core-bound DNA: influencing by carbo
    J Riman
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    Acta Virol 46:75-83. 2002
    ..to the naturally occurring nucleoprotein (NP) complexes harboring an extrachromosomal DNA identical with avian myeloblastosis virus (AMV) core-bound DNA (Ríman and Sulová, Acta Virol...
  65. ncbi Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant
    Miklos Geiszt
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:51661-8. 2004
    ..The shortened cDNA was generated by avian myeloblastosis virus reverse transcriptase, but not by thermally stable reverse transcriptase under conditions that produce ..
  66. ncbi Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells
    C Nicot
    Division of Basic Sciences, Basic Research Laboratory, NIH, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 16:1629-32. 2000
    The B-myb gene was identified on the basis of its homology with the protooncogene c-myb, homolog of the avian myeloblastosis virus (AMV) and avian leukemia virus (E26) transforming genes...
  67. pmc Polymerase incorporation and miscoding properties of 5-chlorouracil
    Cherine H Kim
    Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Chem Res Toxicol 23:740-8. 2010
    ..pair with dATP but also with dGTP, in a pH-dependent manner with incorporation by human polymerase beta, avian myeloblastosis virus reverse transcriptase (AMV-RT), and Escherichia coli Klenow fragment (exo(-)) polymerase...
  68. pmc CUUCGG hairpins: extraordinarily stable RNA secondary structures associated with various biochemical processes
    C Tuerk
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309
    Proc Natl Acad Sci U S A 85:1364-8. 1988
    ..b>Avian myeloblastosis virus reverse transcriptase, which can traverse hairpins of larger calculated stability, terminates ..
  69. pmc Detection of hepatitis A virus in Mercenaria mercenaria by coupled reverse transcription and polymerase chain reaction
    B B Goswami
    Division of Molecular Biological Research and Evaluation, Food and Drug Administration, Washington, D C 20204
    Appl Environ Microbiol 59:2765-70. 1993
    ..RNA is isolated from hard-shell clam tissue and reverse transcribed with avian myeloblastosis virus reverse transcriptase. A portion of the cDNA pool is then amplified with primers specific for HAV...
  70. ncbi Explorations into neolignan biosynthesis: concise total syntheses of helicterin B, helisorin, and helisterculin A from a common intermediate
    Scott A Snyder
    Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, USA
    J Am Chem Soc 131:1745-52. 2009
    ..3), and helisterculin A (4) are structurally unique natural products with the ability to combat the avian myeloblastosis virus. Biogenetically, their architectures are considered to be products of seemingly straightforward Diels-..
  71. ncbi Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBPalpha or C/EBPbeta and tom-1A promoter fragment
    T H Tahirov
    Kanagawa Academy of Science and Technology KAST, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Acta Crystallogr D Biol Crystallogr 57:1655-8. 2001
    ..v-Myb encoded by avian myeloblastosis virus (AMV) is a mutated form of c-Myb that contains point mutations which disrupt the cooperation with C/EBPs...
  72. ncbi Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter
    Tahir H Tahirov
    Kanagawa Academy of Science and Technology, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell 108:57-70. 2002
    c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes...
  73. ncbi Single-tube fluorescent product-enhanced reverse transcriptase assay with Ampliwax (STF-PERT) for retrovirus quantitation
    Johnna F Sears
    Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol Methods 108:139-42. 2003
    ..The STF-PERT assay can be used to quantitate low amounts of retrovirus in clinical and research materials and to evaluate retrovirus contamination in cell substrates and biological products in human use...
  74. ncbi Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas
    S Crews
    Science 218:1319-21. 1982
    ..The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay...
  75. ncbi Hemin inhibits virion-associated reverse transcriptase of murine leukemia virus
    K Tsutsui
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Biochem Biophys Res Commun 149:628-34. 1987
    ..The hemin inhibition was reversible and appears to be directed against the enzyme rather than the template. Hemin did not inhibit the activity of reverse transcriptase purified from avian myeloblastosis virus.
  76. pmc Pausing of reverse transcriptase on retroviral RNA templates is influenced by secondary structures both 5' and 3' of the catalytic site
    G P Harrison
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA
    Nucleic Acids Res 26:3433-42. 1998
    ..We propose that homopolyadenosine tracts can act as termination signals for RT in the context of inverted repeats as they do for certain RNA polymerases...
  77. ncbi Deletions within the U3 long terminal repeat alter the tumorigenic potential of myeloblastosis associated virus type 1(N)
    Chéraz Khelifi-Younes
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, Paris, France
    Virology 316:84-9. 2003
    ..The results obtained indicated that deletions of the LTRs resulted in a modification of the pathogenic spectrum of MAV-1(N) and a decreased efficiency for nephroblastoma induction...
  78. ncbi Determination of target nucleotides involved in 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000)-DNA adduct formation
    E Touati
    Unité de Programmation Moléculaire et de Toxicologie Génétique, CNRS URA 1444, Institut Pasteur, Paris, France
    Mutagenesis 8:149-54. 1993
    ..In addition, the analysis of DNA replication-blocking properties of R7000 lesions was performed using avian myeloblastosis virus (AMV) reverse transcriptase as DNA polymerase...
  79. ncbi Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus
    H Chen
    Department of Molecular, University of Colorado at Boulder 80309, USA
    Biochemistry 35:6923-30. 1996
    ..This ligand was specific for the FIV enzyme and did not inhibit other reverse transcriptases tested (avian myeloblastosis virus, Moloney murine leukemia virus, and human immunodeficiency virus type 1).
  80. ncbi Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:44582-9. 2004
    ..The v-myb gene carried by avian myeloblastosis virus has a transforming capacity, but the c-myb proto-oncogene does not...
  81. ncbi High processivity of the reverse transcriptase from a non-long terminal repeat retrotransposon
    Arkadiusz Bibillo
    Department of Biology, University of Rochester, Rochester, New York 14627 0211, USA
    J Biol Chem 277:34836-45. 2002
    ..we compare various properties of the R2 RT activity with those of the well characterized retroviral RT, avian myeloblastosis virus (AMV)...
  82. ncbi Transcription of the 5'-terminal cap nucleotide by RNA-dependent DNA polymerase: possible involvement in retroviral reverse transcription
    V Z Volloch
    Boston Biomedical Research Institute, MA 02114, USA
    DNA Cell Biol 14:991-6. 1995
    ..Moreover, the demonstrated ability of complementary nucleotides to form hydrogen bonds, even when in a parallel orientation, may have interesting and important consequences...
  83. ncbi Contribution of MAV-1-induced nephroblastoma to the study of genes involved in human Wilms' tumor development
    B Perbal
    UFR de Biochimie, Université Paris 7 D Diderot, France
    Crit Rev Oncog 5:589-613. 1994
    ..The recent data that are discussed in this review strongly suggest that the nov protein might play a critical role in normal and pathological nephrogenesis...
  84. ncbi Okazaki fragments, a constant component of avian myeloblastosis virus core-bound 7 S DNA
    J Riman
    Institute of Molecular Genetics, Academy of Sciences, Prague, Czech Republic
    Acta Virol 37:305-19. 1993
    ..sedimentation properties of the isolated host 7 S DNA species associated with the core fraction of avian myeloblastosis virus (AMV) are made mainly by tight association of RNA pieces prevalently joined to the single-stranded ..
  85. ncbi Association of v-myc protein with chromatin
    K H Klempnauer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Oncogene 4:115-8. 1989
    ..v-myb and v-myc proteins thus share the same subnuclear location and apparently interact directly with the cellular DNA...
  86. ncbi Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases
    Y Take
    Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan
    J Antibiot (Tokyo) 42:107-15. 1989
    ..transcriptase by certain antibiotics and related compounds was studied in comparison with that of avian myeloblastosis virus (AMV) reverse transcriptase and cellular DNA polymerases alpha and beta...
  87. ncbi Kinetic properties of poly (2'-O-methylcytidylic acid)-directed reverse transcriptase reaction
    H Aoyama
    Departamento de Bioquimica, Instituto de Biologia, UNICAMP, Campinas, SP, Brasil
    Braz J Med Biol Res 21:445-8. 1988
    ..The reaction was inhibited by the action of N-ethylmaleimide and novobiocin, and to a lesser extent by ethidium bromide and tetramethyl ethidium bromide...
  88. ncbi Mapping of a small phosphopeptide at the carboxyterminus of the viral myb protein by monoclonal antibodies
    H Bading
    Max Planck Institut fur Molekulare Genetik, Berlin, Federal Republic of Germany
    Oncogene 4:33-8. 1989
    ..antibodies were used for analysing the in vivo phosphorylation site of the oncogene protein from avian myeloblastosis virus (AMV), p48v-myb...
  89. pmc Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae
    H Nakashima
    Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan
    Antimicrob Agents Chemother 31:1524-8. 1987
    ..sulfate A, dermatan sulfate, heparan sulfate, keratan polysulfate, and heparin also inhibited the RT of avian myeloblastosis virus. SAE immediately inhibited RT activity when added to an assay mixture after the start of the reaction.
  90. ncbi Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase
    R Fernandez-Larsson
    Division of Infectious Diseases, Children s Hospital, Boston, Massachusetts
    Mol Pharmacol 38:766-70. 1990
    ..Combination of any of the ribavirin derivatives tested with 3'-azido-3'-deoxythymidine (zidovudine)-5'-triphosphate resulted in an increase of its anti-human immunodeficiency virus reverse transcriptase activity in the in vitro assay...
  91. ncbi Proto-oncogene expression in avian hematopoietic tissues
    E R Schuur
    Department of Pathology, UCLA School of Medicine 90024
    Oncogene 6:1409-15. 1991
    ..Baluda, 1988) have shown that the proto-oncogenes ETS, FPS, MHT (RAF), MYC and REL are expressed in avian myeloblastosis virus (AMV)-transformed cells, whereas the MYB gene is repressed...
  92. pmc Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb
    Carola Wilczek
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Biol Chem 284:35314-24. 2009
    The oncogene v-myb of avian myeloblastosis virus (AMV) encodes a transcription factor (v-Myb) that transforms myelomonocytic cells by deregulating the expression of specific target genes...
  93. ncbi Complete genome amplification of equine influenza virus subtype 2
    G H Sguazza
    Catedra de Virologia, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
    Rev Argent Microbiol 41:207-11. 2009
    ..A ThermoScript reverse transcriptase instead of the avian myeloblastosis virus reverse transcriptase or Moloney murine leukemia virus reverse transcriptase was used...
  94. ncbi Podoscyphic acid, a new inhibitor of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptase from a Podoscypha species
    G Erkel
    LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland
    Z Naturforsch C 46:442-50. 1991
    ..The testing of ethyl (E)-4,5-dioxo-2-hexadecenoate (2) and (E)-4-oxo-2-tetradecenoic acid (11) revealed the importance of the free gamma-oxoacrylic acid unit for the biological activities of 1...
  95. ncbi Inhibition of avian myeloblastosis virus reverse transcriptase by aurochloric acid
    M Semba
    Department of Cell Biology, Food and Drug Safety Center, Kanagawa
    Jpn J Cancer Res 81:1259-64. 1990
    ..the inhibitory effects of aurochloric acid (AuCl4H) on reverse transcriptase (RT) derived from avian myeloblastosis virus and DNA polymerase alpha (pol. alpha) purified from HeLa S3 cells. The activities of RT, pol...
  96. pmc 1 alpha,25-dihydroxyvitamin D3 regulates the transcription of carbonic anhydrase II mRNA in avian myelomonocytes
    A Lomri
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 89:4688-92. 1992
    ..These results suggest that activation of the CAII gene occurs early in the differentiation events triggered by vitamin D3 in myelomonocytic cells...
  97. pmc A comparison of the fidelity of copying 5-methylcytosine and cytosine at a defined DNA template site
    J C Shen
    Department of Biochemistry, University of Southern California School of Medicine, Los Angeles 90033
    Nucleic Acids Res 20:5119-25. 1992
    ....
  98. pmc Formation of phosphonester bonds catalyzed by DNA polymerase
    L S Victorova
    Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow, Russia
    Nucleic Acids Res 20:783-9. 1992
    ..The 3'----5'-exonuclease activity of DNA polymerase I, Klenow fragment, hydrolyzed DNA fragments containing phosphonomethyl internucleoside groups, while such DNA fragments were resistant to the E. coli exonuclease III...
  99. ncbi Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
    K Damm
    Gene Expression Laboratory, Howard Hughes Medical Institute, La Jolla, California
    Nature 339:593-7. 1989
    ..Thus, v-erbA may be the first example of a dominant negative oncogene...
  100. pmc Nucleotide sequence of cDNA clones of the murine myb proto-oncogene
    T J Gonda
    EMBO J 4:2003-8. 1985
    ..has shown that these clones extend both 5' and 3' to sequences homologous to the v-myb oncogenes of avian myeloblastosis virus and avian leukemia virus E26...
  101. ncbi Sequential study of visceral lesions caused by isolates of an avian osteopetrosis virus (myeloblastosis-associated virus)
    B E Powers
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523
    Am J Vet Res 49:1589-97. 1988
    ..Conversely, viral particles and antigen were minimal in tissues from embryos inoculated with the rapid-onset isolate, yet intravascular cellular thrombi, substantial cell necrosis, and increased heterophils and hemocytoblasts were found...

Research Grants8

  1. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
    The Myb gene family was first discovered because the v-Myb oncogene of the avian myeloblastosis virus (AMV) causes a rapidly fatal leukemia in chickens...
  2. Function of the Drosophila Myb Proto-Oncogene
    Joseph Lipsick; Fiscal Year: 2005
    ..c-Myb is the cellular homologue of the v-Myb retroviral oncogene that is present in the avian myeloblastosis virus and the E26 leukemia virus...
  3. TUMOR INDUCTION BY AVIAN MYELOBLASTOSIS VIRUS
    MARCEL BALUDA; Fiscal Year: 1993
    ..of the molecular mechanism of leukemogenesis in chicken hematopoietic cells by the oncogene v-myb of avian myeloblastosis virus (AMV) which is derived from the cellular proto-oncogene c-myb by truncation at both termini...
  4. TRANSFORMATION BY THE MYB ONCOGENE
    Joseph Lipsick; Fiscal Year: 1993
    ..In particular, we will further mutate the v- myb oncogene of the avian myeloblastosis virus (AMV) in order to produce altered froms of p48v-myb with which to test the correlation between ..
  5. VIRUS INDUCED MYELOID LEUKEMIA
    David Boettiger; Fiscal Year: 1990
    ..b>Avian myeloblastosis virus (AMV) which carries the prototypic v-myb oncognee has a target cell populations which appears to be ..