enterovirus

Summary

Summary: A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".

Top Publications

  1. ncbi An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    M Ho
    National Health Research Institutes, Taipei, Taiwan
    N Engl J Med 341:929-35. 1999
  2. ncbi An overview of the evolution of enterovirus 71 and its clinical and public health significance
    Peter C McMinn
    Division of Virology, TVW Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, WA 6008, Australia
    FEMS Microbiol Rev 26:91-107. 2002
  3. ncbi Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
  4. pmc Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens
    W Allan Nix
    Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:2698-704. 2006
  5. ncbi The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains
    Yan Wu
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Int J Infect Dis 14:e1076-81. 2010
  6. ncbi Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    C N Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 20:895-904. 2001
  7. ncbi Neurologic complications in children with enterovirus 71 infection
    C C Huang
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    N Engl J Med 341:936-42. 1999
  8. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
  9. ncbi Enterovirus surveillance--United States, 1970-2005
    Nino Khetsuriani
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases proposed, CDC, 1600 Clifton Road, NE, MS A 34, Atlanta, Georgia 30333, USA
    MMWR Surveill Summ 55:1-20. 2006
  10. pmc Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    B A Brown
    Division of Viral Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Virol 73:9969-75. 1999

Research Grants

Detail Information

Publications322 found, 100 shown here

  1. ncbi An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    M Ho
    National Health Research Institutes, Taipei, Taiwan
    N Engl J Med 341:929-35. 1999
    ..In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom ..
  2. ncbi An overview of the evolution of enterovirus 71 and its clinical and public health significance
    Peter C McMinn
    Division of Virology, TVW Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, WA 6008, Australia
    FEMS Microbiol Rev 26:91-107. 2002
    Since its discovery in 1969, enterovirus 71 (EV71) has been recognised as a frequent cause of epidemics of hand-foot-and-mouth disease (HFMD) associated with severe neurological sequelae in a small proportion of cases...
  3. ncbi Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
    b>Enterovirus 71 (EV71) infections in children manifest as exanthema and are most commonly known as hand-foot-and-mouth disease (HFMD)...
  4. pmc Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens
    W Allan Nix
    Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:2698-704. 2006
    A reverse transcription-seminested PCR (RT-snPCR) assay was developed for the detection and identification of enterovirus (EV) RNA in clinical specimens...
  5. ncbi The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains
    Yan Wu
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge 117597, Singapore
    Int J Infect Dis 14:e1076-81. 2010
    ..During 2008, Singapore experienced its largest ever outbreak of hand, foot and mouth disease (HFMD), resulting in 29686 cases, including four cases of encephalitis and one fatality...
  6. ncbi Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    C N Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 20:895-904. 2001
    b>Enterovirus 71 (EV71), the newest member of Enteroviridae, is notable for its etiological role in epidemics of severe neurological diseases in children. Developing effective vaccines is considered a top choice among all control measures...
  7. ncbi Neurologic complications in children with enterovirus 71 infection
    C C Huang
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    N Engl J Med 341:936-42. 1999
    b>Enterovirus 71 infection causes hand-foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting, ulcerative lesions in the oral mucosa, and vesicles on the backs of the hands and feet...
  8. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
    b>Enterovirus 71 (EV71) infections manifest most commonly as a childhood exanthema known as hand-foot-and-mouth disease (HFMD) and can cause neurological disease during acute infection.
  9. ncbi Enterovirus surveillance--United States, 1970-2005
    Nino Khetsuriani
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases proposed, CDC, 1600 Clifton Road, NE, MS A 34, Atlanta, Georgia 30333, USA
    MMWR Surveill Summ 55:1-20. 2006
    ..g., aseptic meningitis, paralysis, myocarditis, and neonatal enteroviral sepsis). Multiple enterovirus serotypes exist...
  10. pmc Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    B A Brown
    Division of Viral Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Virol 73:9969-75. 1999
    b>Enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis...
  11. ncbi Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
    Taiwan experienced several epidemics of enterovirus 71 (EV71) infections, which were associated with brainstem encephalitis (BE) and pulmonary edema (PE)...
  12. pmc Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua
    Nathan L Yozwiak
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA
    J Virol 84:9047-58. 2010
    ..In this study, we report the identification and complete genome sequence of a novel enterovirus isolated from a case of acute respiratory illness in a Nicaraguan child...
  13. ncbi Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides
    Damian Guang Wei Foo
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Virus Res 125:61-8. 2007
    b>Enterovirus 71 (EV71) is the main causative agent of Hand, foot and mouth disease (HFMD) and has been associated with severe neurological diseases resulting in high mortalities...
  14. ncbi Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia
    P McMinn
    Department of Microbiology, Princess Margaret Hospital for Children, Perth, WA, Australia
    Clin Infect Dis 32:236-42. 2001
    b>Enterovirus 71 (EV71) causes epidemics of hand, foot, and mouth disease associated with neurological complications in young children...
  15. ncbi Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus
    B A Brown
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virus Res 39:195-205. 1995
    b>Enterovirus 71 (EV71) is capable of causing paralytic disease indistinguishable from poliomyelitis due to poliovirus...
  16. ncbi Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice
    C K Yu
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    J Biomed Sci 7:523-8. 2000
    Experimental infection with enterovirus type 71 (EV71) induced death in neonatal mice in an age- and dose-dependent manner...
  17. ncbi Clinical and molecular characterization of hand-foot-and-mouth disease in Thailand, 2008-2009
    Susheera Chatproedprai
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Jpn J Infect Dis 63:229-33. 2010
    ..disease (HFMD) is caused by a group of enteroviruses, most commonly coxsackievirus A 16 (CA16) and enterovirus 71 (EV71)...
  18. pmc An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010
    Sung Hsi Wei
    Taiwan Centers for Disease Control, Taipei, Taiwan
    BMC Infect Dis 11:346. 2011
    ..Therefore, we performed an epidemiological and molecular investigation to elucidate the characteristics of this outbreak...
  19. pmc Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009
    Fan Yang
    State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Virol J 8:508. 2011
    ..However, people are still only concerned with human enterovirus 71(HEV-71) and coxsackie virus A16 (CV-A16)...
  20. ncbi Epidemiologic features and virus isolation of enteroviruses in Northern Taiwan during 2000-2008
    Kuo Chien Tsao
    Research Center for Emerging Viral Infections, Chang Gung University, Kwei Shan, Tao Yuan, Taiwan
    J Virol Methods 165:330-2. 2010
    ..RD cells were susceptible to most serotypes of enteroviruses, especially for human enterovirus A...
  21. pmc Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore
    Kwai Peng Chan
    Virology Laboratory, Department of Pathology, Singapore General Hospital, Outram Road, Singapore
    Emerg Infect Dis 9:78-85. 2003
    ..cultures on 311 and 157 specimens from 175 HFMD patients and 107 non-HFMD patients, respectively; human enterovirus 71 (HEV71) was the most frequently isolated virus from both groups...
  22. pmc A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection
    Ya fang Wang
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Virol 78:7916-24. 2004
    A mouse-adapted enterovirus 71 (EV71) strain with increased virulence in mice, MP4, was generated after four serial passages of the parental EV71 strain 4643 in mice...
  23. pmc Molecular analysis of virulent determinants of enterovirus 71
    Renqing Li
    Beijing Center for Disease Control and Prevention, Beijing, China
    PLoS ONE 6:e26237. 2011
    b>Enterovirus 71 (EV71) is the most important causative agent of hand, foot and mouth disease (HFMD) in children. In most cases, it is a self-limiting illness...
  24. pmc Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008
    Zhen Zhu
    State Key Laboratory for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No 155, Changbai Road, Changping District, Beijing 102206, China
    Virol J 7:300. 2010
    ..This study aims to identify the situation of natural human enterovirus 71 (HEV71) and coxsackievirus A16 (CVA16) infections in children before 2008 in China.
  25. pmc Frequency and dynamics of recombination within different species of human enteroviruses
    Peter Simmonds
    Virus Evolution Group, Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Virol 80:483-93. 2006
    ..phylogenies between three regions of the genome (VP4, VP1, and 3Dpol) were compared among species A and B enterovirus variants detected in a human population-based survey in Scotland between 2000 and 2001, along with contemporary ..
  26. pmc Typing of human enteroviruses by partial sequencing of VP1
    M S Oberste
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1288-93. 1999
    ..The neutralization assay is usually used for enterovirus typing, but it is labor-intensive and time-consuming and standardized antisera are in limited supply...
  27. ncbi High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture
    Chia Chyi Liu
    Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Vaccine 25:19-24. 2007
    Developing an effective vaccine against enterovirus 71 (EV71) infection provides the best means to control the disease...
  28. ncbi Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system
    Tzou Yien Lin
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Clin Infect Dis 36:269-74. 2003
    b>Enterovirus 71 (EV71) infection can lead to devastating clinical outcomes. An appreciation of the scientific relationship between cytokine response and patient mortality may help limit the risks posed by this deadly illness...
  29. ncbi Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71
    Kuei Hsiang Lin
    Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung City, Taiwan
    J Med Virol 78:254-62. 2006
    In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak in 1998...
  30. ncbi Molecular typing and epidemiology of non-polio enteroviruses isolated from Yunnan Province, the People's Republic of China
    Tian Bingjun
    Polio Laboratory, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, The People s Republic of China
    J Med Virol 80:670-9. 2008
    ..Based on molecular typing, 5 isolates were classified into 5 serotypes of the human enterovirus A species, 158 isolates, into 35 serotypes of the human enterovirus B species; and 32 isolates, into 6 ..
  31. ncbi Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998
    H Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 52:12-5. 1999
    b>Enterovirus 71 (EV71), one of the major causative agents for hand, foot and mouth disease (HFMD), is sometimes associated with severe central nervous system diseases...
  32. ncbi Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany
    Holger F Rabenau
    Institute of Medical Virology, Hospital of the Johann Wolfgang Goethe University of Frankfurt, Frankfurt, Germany
    Med Microbiol Immunol 199:45-51. 2010
    Coxsackie A16 (CA16) and Enterovirus 71 (EV71) are members of the picornaviridae family and are associated with hand, foot and mouth disease (HFMD), in rare cases also to acute neurological diseases...
  33. ncbi Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008
    Haiyang Yu
    Department of Microbiology, Anhui Medical University, 230032, Hefei, Anhui, China
    Virus Genes 41:1-4. 2010
    b>Enterovirus 71 (EV71) strains from children were characterized by full-length VP1 nucleotide sequencing. Out of 22 clinical specimens, five isolates identified as EV71 were recovered by virus isolation...
  34. ncbi Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study
    Mong How Ooi
    Department of Paediatrics, Sibu Hospital, Sibu, Malaysia
    Clin Infect Dis 44:646-56. 2007
    Human enterovirus (HEV)-71 causes large outbreaks of hand-foot-and-mouth disease with central nervous system (CNS) complications, but the role of HEV-71 genogroups or dual infection with other viruses in causing severe disease is unclear.
  35. pmc Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
    b>Enterovirus 71 (EV71) causes childhood hand, foot, and mouth disease and neurological complications, and no vaccines or therapeutic drugs are currently available...
  36. ncbi Neurodevelopment and cognition in children after enterovirus 71 infection
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    N Engl J Med 356:1226-34. 2007
    b>Enterovirus 71 is a common cause of hand, foot, and mouth disease and encephalitis in Asia and elsewhere. The long-term neurologic and psychiatric effects of this viral infection on the central nervous system (CNS) are not well understood.
  37. pmc Coxsackievirus A6 and hand, foot, and mouth disease, Finland
    Riikka Osterback
    University of Turku, Turku, Finland
    Emerg Infect Dis 15:1485-8. 2009
    ..We identified an unusual enterovirus type, coxsackievirus A6 (CVA6), as the causative agent...
  38. ncbi Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease
    L Y Chang
    Department of Pediatrics, Chang Gung Children s Hospital, Kweishan, Taoyuan, Taiwan
    Lancet 354:1682-6. 1999
    In Taiwan, from April to July, 1998, an epidemic of hand, foot, and mouth disease associated with enterovirus 71 (EV71) occurred with fatal complications. We did a clinical study of EV71-related diseases in Taiwan.
  39. ncbi Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity
    S M Wang
    Department of Emergency Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Clin Microbiol Infect 13:677-82. 2007
    Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998...
  40. pmc Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China
    Linlin Li
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese CDC, No 6 Rongjing East Street, Yi zhuang, Beijing 100176, China
    J Clin Microbiol 43:3835-9. 2005
    The genetic and phylogenetic characteristics of human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) sampled from children with hand, foot, and mouth disease in Shenzhen, People's Republic of China, over a 6-year period (1999 to ..
  41. pmc Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years
    Yuwana Podin
    Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Jalan Datuk Musa, Kota Samarahan, Sarawak, Malaysia
    BMC Public Health 6:180. 2006
    A major outbreak of human enterovirus 71-associated hand, foot and mouth disease in Sarawak in 1997 marked the beginning of a series of outbreaks in the Asia Pacific region...
  42. pmc Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000
    Jen Ren Wang
    Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Microbiol 40:10-5. 2002
    ..Of the virus isolates, enterovirus 71 (EV71) was diagnosed in 44.4% of the patients (132 of 297) in 1998, 2% (13 of 646) in 1999, and 20...
  43. ncbi A murine oral enterovirus 71 infection model with central nervous system involvement
    Yi Chun Chen
    Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Gen Virol 85:69-77. 2004
    b>Enterovirus 71 (EV71) infection causes a myriad of diseases from mild hand-foot-and-mouth disease or herpangina to fatal meningoencephalitis complicated with neurogenic pulmonary oedema...
  44. ncbi Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland
    Soile Blomqvist
    National Institute for Health and Welfare THL, Department of Infectious Disease Surveillance and Control, Gastrointestinal Infections Unit, PO Box 30, 00271 Helsinki, Finland
    J Clin Virol 48:49-54. 2010
    ..The outbreak was untypical since a considerable number of clinically diagnosed patients were adults. Furthermore, many of the patients suffered from onychomadesis several weeks after the acute phase of HFMD...
  45. pmc Evidence of recombination among enteroviruses
    J Santti
    MediCity Research Laboratory and Department of Virology, University of Turku, FIN 20520 Turku, National Public Health Institute, FIN 00300 Helsinki, Finland
    J Virol 73:8741-9. 1999
    ..Analysis within the genetic clusters indicated that enterovirus prototype strains include intraspecies recombinants...
  46. pmc Frequent importation of enterovirus 71 from surrounding countries into the local community of Yamagata, Japan, between 1998 and 2003
    K Mizuta
    Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1 6 6, Yamagata, 990 0031 Japan
    J Clin Microbiol 43:6171-5. 2005
    Phylogenetic analysis of 45 enterovirus 71 (EV71) isolates for 6 years in Yamagata, Japan, clarified that the annual outbreak of hand-foot-and-mouth disease was due to four genetically distinct subgenogroups, including a novel "B5...
  47. ncbi Enteroviruses in the pathogenesis of type 1 diabetes
    Sisko Tauriainen
    Department of Virology, Medical School, University of Tampere, Biokatu 10, FIN 33520, Tampere, Finland
    Semin Immunopathol 33:45-55. 2011
    ..in cross-sectional and prospective studies, these observations fit to a scenario where certain diabetogenic enterovirus variants establish persistent infection in gut mucosa and in the pancreatic islets...
  48. ncbi Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells
    Lien Cheng Chen
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Med Virol 78:780-6. 2006
    T-cell depletion is found in enterovirus 71 (EV71)-infected patients with pulmonary edema. However, the mechanism that causes T-cell depletion is unclear...
  49. ncbi Diverse apoptotic pathways in enterovirus 71-infected cells
    Shih Cheng Chang
    Graduate Institute of Basic Medical Sciences, Chang Gung University, Tao Yuan, Taiwan
    J Neurovirol 10:338-49. 2004
    Mechanisms related to the neuropathogenesis of enterovirus 71 infection remain unclear. This investigation conducts a comprehensive study of the apoptotic pathways in neural and non-neural cells following enterovirus 71 infection...
  50. ncbi Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009
    Shih Hsuan Lo
    Department of Pediatrics, Children s Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Microbiol Immunol Infect 44:252-7. 2011
    ..This study is to define clinical manifestations and laboratory findings of Cox A6 infection in children...
  51. pmc Challenges to licensure of enterovirus 71 vaccines
    Min Shi Lee
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Taiwan
    PLoS Negl Trop Dis 6:e1737. 2012
    Human enteroviruses usually cause self-limited infections except polioviruses and enterovirus 71 (EV71), which frequently involve neurological complications. EV71 vaccines are being evaluated in humans...
  52. ncbi Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005
    Kow Tong Chen
    Department of Public Health, College of Medicine, National Cheng Kung University, Taiwan No 1, University Road, Tainan, Taiwan
    Pediatrics 120:e244-52. 2007
    In 1998, an epidemic of hand-foot-mouth disease/herpangina was caused by human enterovirus 71 infection in Taiwan. The underlying factors of widespread emergence of viral infection are unclear...
  53. ncbi Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses
    Javier López Davia
    Dermatology Service, University General Hospital Consortium, Valencia, Spain
    Pediatr Dermatol 28:1-5. 2011
    ..Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%)...
  54. ncbi Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71
    Tsuguto Fujimoto
    Infectious Disease Research Division, Hyogo Prefectural Institute of Public Health and Environmental Sciences, Kobe, Japan
    Microbiol Immunol 46:621-7. 2002
    Few outbreaks of the serious enterovirus 71 (EV71) infections, which affect the central nervous system (CNS), had been reported in Japan before 2000...
  55. ncbi [Molecular diagnosis of respiratory enterovirus infections: Use of PCR and molecular identification for a best approach of the main circulating strains during 2008]
    J Petitjean-Lecherbonnier
    Laboratoire de virologie humaine et moléculaire, CHU de Caen, Avenue Georges Clemenceau, 14033 Caen, France
    Pathol Biol (Paris) 59:113-21. 2011
    The PCR assays are currently used in diagnosis of enterovirus (EV) meningitis. Nevertheless, the use of molecular diagnosis of EV should be investigated in respiratory tract infections (RTI).
  56. ncbi Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71
    Noriyo Nagata
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Virol 67:207-16. 2002
    Among the enteroviruses, polioviruses and enterovirus 71 (EV71) are two major neurotropic viruses causing serious neurological manifestations...
  57. pmc Direct detection of enterovirus 71 (EV71) in clinical specimens from a hand, foot, and mouth disease outbreak in Singapore by reverse transcription-PCR with universal enterovirus and EV71-specific primers
    Sunita Singh
    Programme in Infectious Diseases, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore 117597
    J Clin Microbiol 40:2823-7. 2002
    ..aim of this study was to determine the applicability of reverse transcription-PCR (RT-PCR) with universal pan-enterovirus primers and enterovirus 71 (EV71) type-specific primers for the direct detection of enteroviruses in clinical ..
  58. ncbi An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations
    C C Liu
    Department of Pediatrics, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, Taiwan, ROC
    J Clin Virol 17:23-30. 2000
    An outbreak of enterovirus infections occurred throughout Taiwan in 1998. The diseases were manifectated with hand, foot, and mouth disease (HFMD), some associated with meningitis, encephalitis, or acute flaccid paralysis (AFP).
  59. pmc Retrograde axonal transport: a major transmission route of enterovirus 71 in mice
    Che Szu Chen
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China
    J Virol 81:8996-9003. 2007
    Inoculation of enterovirus 71 (EV71) by the oral (p.o.), intramuscular (i.m.), or intracranial route resulted in brain infection, flaccid paralysis, pulmonary dysfunction, and death of 7-day-old mice...
  60. ncbi Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taiwan
    J Med Virol 67:217-23. 2002
    In 1998, an epidemic of hand-foot-and-mouth disease and herpangina caused by enterovirus 71 occurred in Taiwan, leaving many fatalities and severely handicapped survivors in its wake...
  61. ncbi An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan
    Shou Chien Chen
    Department of Family Medicine, Taipei City Hospital, Taipei, Taiwan, Republic of China
    Am J Trop Med Hyg 77:188-91. 2007
    In 1998, an epidemic of enterovirus 71 (EV 71) infection occurred in Taiwan. The purpose of this study was to assess the epidemiology of EV 71 infection in Taiwan...
  62. ncbi Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 86:1391-401. 2005
    b>Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease and is sometimes associated with serious neurological disorders...
  63. ncbi Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development
    Suh Chin Wu
    Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan
    Vaccine 22:3858-64. 2004
    b>Enterovirus 71 (EV71) is an enterovirus that could lead to severe neurological disorders and fatalities. The inactivated vaccine is an appropriate EV71 vaccine format for meeting current needs...
  64. ncbi Type I interferons protect mice against enterovirus 71 infection
    Ming Liang Liu
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China
    J Gen Virol 86:3263-9. 2005
    In this study, the contribution of type I interferons (IFNs) to protection against infection with enterovirus 71 (EV71) was investigated using a murine model where the virus was administrated to neonatal Institute of Cancer Research (ICR)..
  65. ncbi Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data
    Fan Chen Tseng
    Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
    J Med Virol 79:1850-60. 2007
    b>Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance...
  66. ncbi Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation
    Noriyo Nagata
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 85:2981-9. 2004
    Poliovirus and enterovirus 71 (EV71) are both neurotropic enteroviruses that cause serious neurological diseases, such as poliomyelitis and encephalitis...
  67. pmc Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice
    Te Chia Wu
    Department of Microbiology, Institute of Basic Medical Sciences, Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Virol 81:10310-5. 2007
    In this study, we sought to determine whether intratypic and intertypic cross-reactivity protected against enterovirus 71 (EV71) infection in a murine infection model...
  68. pmc An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Virol 81:9386-95. 2007
    b>Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also sometimes associated with serious neurological disorders...
  69. ncbi Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death
    Rei Lin Kuo
    Institute of Microbiology and Immunology, School of Life Science, National Yang Ming University, Taipei 112, Taiwan
    J Gen Virol 83:1367-76. 2002
    b>Enterovirus 71 (EV71) is the causative agent of human diseases with distinct severity, from mild hand-foot-and-mouth disease to severe neurological syndromes, such as encephalitis and meningitis...
  70. ncbi Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
    Pediatr Res 60:466-71. 2006
    We valuated specific cellular and humoral immune response of cases of enterovirus 71 (EV71) infection and correlated immune response with clinical outcome...
  71. ncbi Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
    Didier Hober
    Laboratoire de Virologie EA3610 Pathogenèse Virale du Diabète de Type 1, Faculte de Medecine, Universite Lille 2, CHRU Lille, Centre de Biologie et Pathologie et Institut Hippocrate Parc Eurasanté, Boulevard du Prof J Leclercq, 59037 Lille Cedex, France
    Nat Rev Endocrinol 6:279-89. 2010
    ..An increased activity of the IFIH1 protein may promote the development of T1DM. An improved knowledge of the pathogenic mechanisms of enterovirus infections should help to uncover preventive strategies for T1DM.
  72. pmc Enteroviruses in patients with acute encephalitis, uttar pradesh, India
    Gajanan N Sapkal
    National Institute of Virology, Pune, India
    Emerg Infect Dis 15:295-8. 2009
    ..to identify an etiologic agent in cerebrospinal fluid by using reverse transcription-PCR showed positivity to enterovirus (EV) in 66 (21.6%) of 306 patients. Sequencing and phylogenetic analyses of PCR products from 59 (89...
  73. pmc New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses
    Caroline Tapparel
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 15:719-26. 2009
    ..We identified and completed the genome sequence of a new enterovirus genotype associated with respiratory symptoms and acute otitis media, confirming the close relationship between ..
  74. pmc Quantitative detection of hepatitis a virus and enteroviruses near the United States-Mexico border and correlation with levels of fecal indicator bacteria
    Richard M Gersberg
    Graduate School of Public Health, Department of Biology, San Diego State University, San Diego, CA 92182, USA
    Appl Environ Microbiol 72:7438-44. 2006
    ..HAV and enterovirus were detected in 79 and 93% of the wet-weather samples, respectively...
  75. pmc Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1
    Huifang M Zhang
    Department of Pathology and Laboratory Medicine, University of British Columbia, The Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Virol 84:8446-59. 2010
    ..Taken together, these data suggest that CVB3 infection activates UPR pathways and induces ER stress-mediated apoptosis through the suppression of P58(IPK) and induction/activation of CHOP, SREBP1, and caspase-12...
  76. ncbi Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection
    Barbara M Schulte
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Viral Immunol 23:99-104. 2010
    ..We investigated (1) whether enterovirus is present at the onset of T1D in peripheral blood mononuclear cells (PBMC), plasma, throat, or stool, and (2) ..
  77. ncbi Appearance of mosaic enterovirus 71 in the 2008 outbreak of China
    Nai Zheng Ding
    School of Biological Science and Technology, Central South University, Hunan Province, China
    Virus Res 145:157-61. 2009
    b>Enterovirus 71 (EV71) is a pathogen of hand-foot-and-mouth disease (HFMD). In the last year and this spring, HFMD caused by EV71 repeatedly broke out and has resulted in at least 50 children's death in China...
  78. pmc Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Virol 82:1787-97. 2008
    b>Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also associated with serious neurological disorders...
  79. pmc Epidemiological, molecular, and clinical features of enterovirus respiratory infections in French children between 1999 and 2005
    Jerome Jacques
    Laboratoire de Virologie, Centre Hospitalier Universitaire, Reims, France
    J Clin Microbiol 46:206-13. 2008
    ..Moreover, the concomitant or successive circulation of genetically distinct EV strains indicated the possibility of pediatric repeated respiratory infections within the same epidemic season...
  80. pmc A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
    Hideo Negishi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:20446-51. 2008
    ..Taken together, our results indicate a critical cooperation of the RIG-I/MDA5-type I IFN and the TLR3-type II IFN signaling axes for efficient innate antiviral immune responses...
  81. ncbi Isolation of enterovirus strains from children with preclinical Type 1 diabetes
    K K Salminen
    Juvenile Diabetes Research Foundation Center for Prevention of Type 1 Diabetes in Finland
    Diabet Med 21:156-64. 2004
    To develop methods for isolation of enterovirus strains from subjects with preclinical Type 1 diabetes and evaluate if their presence in stools is associated with beta-cell damage.
  82. ncbi Enterovirus RNA in serum is a risk factor for beta-cell autoimmunity and clinical type 1 diabetes: a prospective study. Childhood Diabetes in Finland (DiMe) Study Group
    M Lonnrot
    JDFI Center for Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    J Med Virol 61:214-20. 2000
    Recent prospective studies have documented serologically an increased frequency of enterovirus infections in prediabetic children, indicating that these infections may initiate and accelerate the beta-cell damaging process several years ..
  83. pmc Recombination in circulating enteroviruses
    Alexander N Lukashev
    Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia
    J Virol 77:10423-31. 2003
    ..phylogenetic relationships in four genome regions, VP1, 2A, 3D, and the 5' nontranslated region (NTR), of 40 enterovirus B strains (coxsackie B viruses and echoviruses) representing 11 serotypes and isolated in 1981 to 2002 in the ..
  84. ncbi Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Pediatr Int 46:231-5. 2004
    Recently, there have been large outbreaks of hand, foot and mouth disease (HFMD) mainly caused by enterovirus 71 (EV71) associated with severe neurological diseases in the Western Pacific Region (WPR)...
  85. ncbi Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    J Med Virol 72:695-9. 2004
    The persistence of rhinovirus and enterovirus RNAs was studied in the nasal secretions of children with acute expiratory wheezing (median age: 1.7 years)...
  86. ncbi Description and validation of a novel real-time RT-PCR enterovirus assay
    Weston C Hymas
    Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Clin Chem 54:406-13. 2008
    ..of a real-time RT-PCR assay that amplifies a small target in the 5' nontranslated region upstream of the classical Rotbart enterovirus amplicon. The assay includes an RNA internal control and incorporates modified nucleotide chemistry.
  87. ncbi Comparative evaluation of Taqman real-time PCR and semi-nested VP1 PCR for detection of enteroviruses in clinical specimens
    M Steven Oberste
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Clin Virol 49:73-4. 2010
    Molecular diagnostic tests to detect enterovirus in clinical specimens usually target highly conserved sites in the 5'-non-translated region, allowing detection of all members of the genus...
  88. pmc Typing of human enterovirus by partial sequencing of VP2
    Dorsaf Nasri
    Laboratory of bacteriology virology, GIMAP EA3064, Faculty of Medicine Jacques Lisfranc, 15, rue Ambroise Pare, 42023 Saint Etienne, France
    J Clin Microbiol 45:2370-9. 2007
    The sequencing of the VP1 hypervariable region of the human enterovirus (HEV) genome has become the reference test for typing field isolates...
  89. ncbi Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E
    Bing Ching Ho
    Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Cell Host Microbe 9:58-69. 2011
    ..Here we describe another mechanism whereby miR-141 induced upon enterovirus infection targets the cap-dependent translation initiation factor, eIF4E, for shutoff of host protein synthesis...
  90. pmc A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy
    Carlos Gorbea
    Department of Pediatrics Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:23208-23. 2010
    ..These data suggest that individuals harboring these variants may have a blunted innate immune response to enteroviral infection, leading to reduced viral clearance and an increased risk of cardiac pathology...
  91. pmc Activity of pleconaril against enteroviruses
    D C Pevear
    ViroPharma Incorporated, Exton, Pennsylvania 19341, USA
    Antimicrob Agents Chemother 43:2109-15. 1999
    The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly isolated enterovirus serotypes was examined...
  92. ncbi Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR
    J J Yan
    Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    J Med Virol 65:331-9. 2001
    ..Hand, foot, and mouth disease (HFMD) and encephalomyelitis were two major clinical manifestations during the 1998 enterovirus 71 (EV71) epidemic in Taiwan...
  93. ncbi High-titred neutralizing antibodies to human enterovirus 71 preferentially bind to the N-terminal portion of the capsid protein VP1
    C S Tan
    Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia
    Arch Virol 152:1069-73. 2007
    Human enterovirus 71 has emerged as an important pathogen of children in the Asia Pacific region, and it may be important to consider the development of a vaccine against this virus...
  94. pmc Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis
    Sandra Jäkel
    Charite Universitatsmedizin Berlin, Institut für Biochemie CC2, Monbijoustrasse 2, D 10117 Berlin, Germany
    Am J Pathol 175:510-8. 2009
    ..In conclusion, type-I IFN-induced myocardial IP activity at early stages coincides with less severe disease manifestation in CVB3-induced myocarditis...
  95. pmc Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis
    Ying Liu
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 6:e1001066. 2010
    ..of decades-long studies, the mechanism of morphogenesis of plus-stranded RNA viruses belonging to the genus Enterovirus of Picornaviridae, including poliovirus (PV), is not understood...
  96. ncbi Enteroviruses, type 1 diabetes and hygiene: a complex relationship
    S Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Rev Med Virol 20:106-16. 2010
    ..Viewing T1D in this perspective suggests that potential preventative options could be developed...
  97. ncbi Molecular epidemiology of enterovirus 71 in Taiwan
    P Y Chu
    School of Medical Technology, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Arch Virol 146:589-600. 2001
    Taiwan suffered a severe and widespread outbreak of enterovirus infection in 1998. More than 400 children were hospitalized, with seventy-eight fatalities due to central nerve system (CNS) involvement and cardiopulmonary collapse...
  98. ncbi Variation in enterovirus receptor genes
    Ase Karttunen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Med Virol 70:99-108. 2003
    The increased incidence of a enterovirus infections observed in patients with type 1 diabetes preceding the development of the clinical disease could be partially explained by variation in the genes coding for enterovirus receptors...
  99. ncbi Enteroviruses in Spain over the decade 1998-2007: virological and epidemiological studies
    G Trallero
    National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Clin Virol 47:170-6. 2010
    ..Human enteroviruses (HEV) are the commonest cause of viral meningitis as well as other pathologies, therefore HEV characterization is important both in patient management and epidemiological investigation...
  100. ncbi Rapid diagnosis of enterovirus infections by real-time PCR on the LightCycler using the TaqMan format
    Thomas Watkins-Riedel
    The Division of Clinical Virology, Institute of Virology and Infectious Diseases, University Hospital Vienna, A 1090, Vienna, Austria
    Diagn Microbiol Infect Dis 42:99-105. 2002
    ..reverse-transcription(RT)-PCR/hybridization assay using the TaqMan format for rapid diagnostic screening of enterovirus (EV) infections was optimized for the real-time LightCycler (LC) technology...
  101. ncbi Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000)
    Sunita Singh
    Programme in Infectious Diseases, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge, Singapore 117597
    Microbiol Immunol 46:801-8. 2002
    b>Enterovirus 71 (EV71) is a major aetiological agent of hand, foot and mouth disease (HFMD). In recent years, several outbreaks in East Asia were associated with neurological complications and numerous deaths...

Research Grants64

  1. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..For example, the human picornavirus, Enterovirus 71, causes encephalitis where patients often present with seizures...
  2. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..Poliovirus (PV), the prototypic human enterovirus, is well characterized at the molecular level and serves as a model organism for detailed studies of human ..
  3. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..Viruses are the most common cause of encephalitis, with >85% of all aseptic encephalitis caused by enterovirus. Human herpes viruses account for 4% of all viral infections, and West Nile virus is the most common of the ..
  4. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    ..We generated a new immunization platform based on Coxsackievirus A21 (CAV21), a common- cold causing enterovirus. This includes (i) a new technology achieving permanent genetic stability of viral vectors for the delivery of ..
  5. Rapid, automated, detection of viral and bacterial pathogens causing meningitis
    Andrew Hemmert; Fiscal Year: 2013
    ..aureus, Streptococcus species, S. agalactiae, S. pneumoniae, S. pyogenes, viridians streptococci, Adenovirus, Enterovirus, Parechovirus, HSV1, HSV2, VZV, EBV, CMV, HHV-6...
  6. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey M Bergelson; Fiscal Year: 2012
    ..Understanding the special mechanisms by which enteroviruses infect polarized cells will reveal new potential drug targets. ..
  7. Mechanisms of neuronal injury during virus infection of the CNS
    CHARLES LEE HOWE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Foodborne and waterborne picornaviruses such as enterovirus 71 are a global health issue...
  8. Enterovirus infection of polarized intestinal cells
    Carolyn B Coyne; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxsackievirus B (CVB), a member of the enterovirus family of RNA viruses, is associated with a number of diverse syndromes, including meningitis, pericarditis, febrile illness, diabetes, dilated ..
  9. Poliovirus Cell Entry Pathways
    James M Hogle; Fiscal Year: 2012
    ..The findings are also expected to be more generally relevant to many other viruses which lack a lipid envelop. Understanding of the viral entry pathways could lead to the development of novel antivirals. ..
  10. Enhanced Surveillance for New Vaccine Preventable Diseases
    Rangaraj Selvarangan; Fiscal Year: 2013
    ..HPeV is a newly described virus closely related to enterovirus (EV)...
  11. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2009
    ..Poliovirus (PV), the prototypic human enterovirus, is well characterized at the molecular level and serves as a model organism for detailed studies of human ..
  12. NIH Director's Pioneer Award
    Karla Kirkegaard; Fiscal Year: 2010
    ..abstract_text> ..
  13. PICORNAVIRUS MOLECULAR BIOLOGY
    Eckard Wimmer; Fiscal Year: 2013
    ..proposed in this grant application to enhance our understanding of the mechanisms by which poliovirus (PV), an enterovirus belonging to the Picornaviridae, encapsidates its genome...
  14. Innate and Adaptive Immune Responses in the Virus-Infected Heart
    J Lindsay Whitton; Fiscal Year: 2013
    ..For how long after viral clearance do epitopes remain detectable in the heart? How do virus-specific CD4+ and CD8+ T cells contribute to virus clearance, and to the development of immunopathological heart disease? ..
  15. 5'End Genomic Deletions and Enterovirus Persistence
    Nora M Chapman; Fiscal Year: 2012
    ..this project, determining how the loss of a genomic region that is vital to replicational efficiency, allows an enterovirus to adapt to a different intracellular environment...
  16. Assembly of a Dodecahedral Virus
    Adam Zlotnick; Fiscal Year: 2013
    ..Dodecahedra share point symmetry with, and are dual to, icosahedra.) We have chosen to examine Bovine Enterovirus (BEV) a non-pathogenic relation of Poliovirus and Human Enterovirus-71...
  17. Translation Regulation by Enterovirus Proteinase
    Richard E Lloyd; Fiscal Year: 2013
    ..SG and perhaps PBs can strongly inhibit virus replication and new insights from this study may lead to novel antiviral strategies. ..
  18. Study of a novel picornavirus genus associated with Acute Flaccid Paralysis
    Amit Kapoor; Fiscal Year: 2012
    ..The level of genetic divergence between species of genus Cosavirus was similar to that between species of genus Enterovirus. Further information regarding HCoSV genetic diversity and epidemiology is now required to clarify its ..
  19. Viral Adaptation to Host Selenium Status
    Melinda A Beck; Fiscal Year: 2012
    ..demonstrated that a nutritionally-deficient human population infected with coxsackievirus A9 (another human enterovirus) exhibited rapid and significant sequence divergence of this virus...
  20. Picornavirus-initiated inflamation: novel parallels from Drosophila
    Siddharth Balachandran; Fiscal Year: 2013
    ....
  21. Enterovirus entry into polarized endothelial cells
    Carolyn B Coyne; Fiscal Year: 2012
    ..Based on these observations, we hypothesize that enterovirus entry into polarized epithelial and endothelial cells is mediated by cell-type-specific intracellular signals ..
  22. Hand, foot and mouth disease death case characterization and population enterovir
    Zhang Jing; Fiscal Year: 2011
    ..and mouth disease with virus carriage rate in population, we will carry out population-based, one-year round enterovirus (EV71 and CoxA16, other enterovirus) carriage rate survey in one HFMD higher-prevalence and one lower-..
  23. CrPV IRES function and animal virus replication in yeast
    SUNNIE THOMPSON; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Although poliovirus, the most well known enterovirus in the picornavirus family, is soon to be declared eradicated by the World Health Organization, there are 66 other distinct human ..
  24. Protein homeostasis mechanisms underlying enterovirus replication and evolution
    Raul Andino; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The focus of this proposal is to dissect the role of Protein Homeostasis in enterovirus replication, evolution and pathogenesis...
  25. CAR PROTEIN AND AUTO IMMUNITY
    Robert Finberg; Fiscal Year: 2002
    ..We plan to define the role of this protein in the induction of auto-immune disease and use transgenic and knock-out mice to define the mechanisms by which viruses stimulate autoimmune responses. ..
  26. EUROPIC america 2002: a conference for picornaviruses
    Eckard Wimmer; Fiscal Year: 2002
    ..Moreover, new dangerous virus strains are emerging (see the recent outbreak of a new strain of enterovirus 71 in Taiwan)...
  27. HEPATITIS A AND GASTROENTERITIS VIRUSES IN MARINE LIFE
    Charles Gerba; Fiscal Year: 1980
    ..we have developed recently involving ultrafiltration or alternate methods for the efficient concentration of enterovirus from large numbers of shellfish will be optimized for the detection of HAV and human rotavirus...
  28. STRUCTURE OF POLIOVIRUS/ANTIVIRAL DRUG COMPLEXES
    JAMES HOGLE; Fiscal Year: 1991
    ..at Purdue University). The information gained from the structures will be used to design and synthesize compounds with altered activities and specificities (in collaboration with Janssen Pharmaceutica and with K.C. Nicolau at RISC)...
  29. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..However, both types of virus are extremely common and not everyone experiencing an enterovirus/adenovirus infection will develop myocarditis. Both host and viral factors determine viral pathogenicity...
  30. VIRAL INTERFERENCE IN CARRIER CULTURES
    Richard Crowell; Fiscal Year: 1992
    ..These results will be correlated with the known patterns of coxsackievirus pathogenesis...
  31. Evaluating dendritic cell activation and function during coxsackievirus infection
    CHRISTOPHER KEMBALL; Fiscal Year: 2009
    ....
  32. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2003
    ..Poliovirus, the prototypic enterovirus, is well characterized at the molecular level and still serves as the most appropriate virus for studies of RNA ..
  33. Structual Analysis of Enterovirus Cell Entry Pathways
    JAMES HOGLE; Fiscal Year: 2002
    ..abstract_text> ..
  34. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey Bergelson; Fiscal Year: 2007
    ..Understanding the special mechanisms by which they infect polarized cells will reveal new potential drug targets. ..
  35. PROSPECTIVE STUDY OF THE OUTCOME OF ASEPTIC MENINGITIS
    John Modlin; Fiscal Year: 1990
    ..There will also be sufficient power to analyze the effect of age of patient, sex, race, socioeconomic status, enterovirus etiology, and severity of original infection on the long-term outcome of aseptic meningitis...
  36. Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    NEIL BOWLES; Fiscal Year: 2009
    ..for TLR3 and we have shown that the integrity of the TLR3 signaling pathway is involved in protecting against enterovirus-induced myocardial damage...
  37. Novel IRES-specific trans acting factors that modulate EV71 translation
    Mei Ling Li; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Enterovirus 71 (EV71), a member of the family Picornavirus, genus enterovirus, is the highly infectious major causative agent of hand, foot, and mouth disease (HFMD)...
  38. BIOLOGY OF C CLUSTER COXSACKIEVIRUSES
    Eckard Wimmer; Fiscal Year: 2000
    ..The 4th specific goal is to define the interactions between the capsid and the receptors of those viruses, including ICAM-1 and DAF with CAV21a, and the relationships between CAV24 and CAV24v. ..
  39. Evolution of Human C-cluster Enteroviruses
    Eckard Wimmer; Fiscal Year: 2003
    C-Cluster enteroviruses are a group of highly infectious igents within Picornav7 dae, genus Enterovirus, that are characterized by closely related genotypes but vastly different pathogenic properties (poliomyelitis vs...
  40. Role of the Alpha 7 Beta 1 Integrin in Muscle Integrity
    Stephen Kaufman; Fiscal Year: 2005
    ..enhanced expression of the alpha7 integrin in the heart reduces development of cardiomyopathy associated with enterovirus-induced cleavage of dystrophin...
  41. COXSACKIEVIRUSES AS CHIMERIC HIV VACCINE VECTORS
    Steven Tracy; Fiscal Year: 2001
    ..Results from this proof-of-principle proposal will test feasibility within an HIV framework. ..
  42. Viral dsRNA as a Mediator of Chronic Muscle Diseases
    PATRICIA TAM; Fiscal Year: 2005
    ..Although they are not known to cause persistent infections, persistent enterovirus RNA has been detected in some patients...
  43. IMMUNOPATHIC MYOSITIS INDUCED BY PERSISTENT VIRUS
    Ronald Messner; Fiscal Year: 2002
    Prior enterovirus infection has been implicated in pathogenesis of certain human autoimmune diseases including the idiopathic inflammatory myopathies, juvenile-onset diabetes, and cardiomyopathy, as well as noninflammatory diseases like ..
  44. PERSISTENCE OF ECHOVIRUS 6 IN CULTURED HUMAN CELLS
    VERA RIGHTHAND; Fiscal Year: 1990
    ..of the proposed research is to study the mechanism(s) of virus persistence in cultured human cells by the human enterovirus, echovirus 6...
  45. Translation Regulation by Enterovirus Proteinase
    Richard Lloyd; Fiscal Year: 2007
    ..This new information will be useful in the broad areas of studies of viral regulation of gene expression, miRNA-mediated translation silencing, and cellular stress responses in cancer and apoptosis. ..
  46. Poliovirus Receptor and Poliovirus Pathogenesis
    Eckard Wimmer; Fiscal Year: 2009
    Following ingestion and entry into the gastrointestinal (Gl) tract, poliovirus, a human neurotropic enterovirus of Picornaviridae, may replicate in gastrointestinal-associated lymphatic tissues (GALT) and, subsequently, spread to the ..
  47. Cellular Determinants of Coxsackievirus Myocarditis
    Paul Krogstad; Fiscal Year: 2009
    ..These experiments will aid our understanding of viral myocarditis and may lead to new therapies for this life-threatening illness. ..
  48. Enhancing CD8 T-cell immunity against coxsackievirus B3
    CHRISTOPHER CORNELL; Fiscal Year: 2006
    ..Our laboratory has found that the closely related enterovirus, coxsackievirus B3 (CVB3), is incapable of inducing a strong CDS* T cell response, and this proposal directly ..
  49. PATHOBIOLOGY OF GI INFECTION AND INFLAMATION
    Michael Gershon; Fiscal Year: 2005
    ..Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S...
  50. ADENOVIRUS-RECEPTOR INTERACTION--STRUCTURE, FUNCTION
    Paul Freimuth; Fiscal Year: 2004
    ..Our results also may have application to the development of vaccines and anti- viral drugs, and they will impact efforts to retarget the tropism of adenovirus-based vectors for gene therapy. ..
  51. Cardiac SOCS Proteins: A Role in Enterovirus Infection
    Kirk Knowlton; Fiscal Year: 2007
    ..These aims will provide a novel insight into the mechanisms by which JAK-STAT-SOCS activation within the cardiac myocyte regulates the innate anti-viral response. ..
  52. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
    ..This work will advance knowledge of cells that form tight _junctions and their interactions with cells and molecules that must cross those barriers. ..
  53. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003
    ..This persisting viral infection contributes to chronic inflammation and cardiomyopathy in later stage enterovirus-related inflammatory heart disease...
  54. The Influence of Nutrition on Influenza Virus Infection
    Melinda Beck; Fiscal Year: 2004
    ..abstract_text> ..
  55. Nutrition, Viral Mutation and Host Defense
    Melinda Beck; Fiscal Year: 2007
    ..abstract_text> ..
  56. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. The Cytoskeleton in HAART-Induced Cardiomyopathy
    David Nelson; Fiscal Year: 2006
    ..Specific Aim 2: Characterization of the cytoskeleton in HAART-treated transgenic mice. Specific Aim 3: Role of extrinsic stimuli in the development of HAART-induced cardiomyopathy. ..