orthomyxoviridae

Summary

Summary: A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.

Top Publications

  1. pmc Absolute humidity modulates influenza survival, transmission, and seasonality
    Jeffrey Shaman
    College of Oceanic and Atmospheric Sciences, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 106:3243-8. 2009
  2. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
  3. pmc The influenza virus resource at the National Center for Biotechnology Information
    Yiming Bao
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Virol 82:596-601. 2008
  4. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
  5. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001
  6. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
  7. ncbi Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
  8. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
  9. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
  10. ncbi Measurement of airborne influenza virus in a hospital emergency department
    Francoise M Blachere
    Division of Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Clin Infect Dis 48:438-40. 2009

Research Grants

Detail Information

Publications251 found, 100 shown here

  1. pmc Absolute humidity modulates influenza survival, transmission, and seasonality
    Jeffrey Shaman
    College of Oceanic and Atmospheric Sciences, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 106:3243-8. 2009
    ..This hypothesis can be further tested through future, additional laboratory, epidemiological and modeling studies...
  2. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
    ..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
  3. pmc The influenza virus resource at the National Center for Biotechnology Information
    Yiming Bao
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Virol 82:596-601. 2008
  4. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
    ..Further research is needed on the viability of airborne influenza viruses and the risk of transmission...
  5. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001
    ..221 cells expressing MHC class I proteinsresulted in the abrogation of the inhibition by NK clones expressing high levels of NKp44. In addition, the binding of NKp44 to HA improves the ability of some NK clones to lyse IV infected cells...
  6. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
    ..Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection...
  7. ncbi Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
    ..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
  8. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
  9. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
    ..These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens...
  10. ncbi Measurement of airborne influenza virus in a hospital emergency department
    Francoise M Blachere
    Division of Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Clin Infect Dis 48:438-40. 2009
    ..Our results provide evidence that influenza virus may spread through the airborne route...
  11. pmc Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus
    Balaji Manicassamy
    Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:11531-6. 2010
    ....
  12. ncbi The epidemiology and evolution of influenza viruses in pigs
    I H Brown
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK
    Vet Microbiol 74:29-46. 2000
    ..Both human H3N2 and avian H1N1 were detected in pigs many years before they acquired the ability to spread rapidly and become associated with disease epidemics in pigs...
  13. pmc Influenza virus entry and infection require host cell N-linked glycoprotein
    Victor C Chu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:18153-8. 2004
    ..We suggest that influenza virus specifically requires N-linked glycoprotein for entry into cells, and that sialic acid, although acting as an efficient attachment factor, is not sufficient as an influenza virus receptor in vivo...
  14. pmc Transmission of influenza virus via aerosols and fomites in the guinea pig model
    Samira Mubareka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 199:858-65. 2009
    ..The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission...
  15. pmc TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells
    Stephanie Bertram
    Institute of Virology, Hannover Medical School, 30625 Hannover, Germany
    J Virol 84:10016-25. 2010
    ..Collectively, our results point toward an important role for TMPRSS2 and possibly TMPRSS4 in influenza virus replication and highlight the former protease as a potential therapeutic target...
  16. pmc Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Clin Invest 120:1663-73. 2010
    ..These findings reveal that seasonal influenza vaccination can induce polyclonal heterosubtypic neutralizing antibodies that cross-react with the swine-origin pandemic H1N1 influenza virus and with the highly pathogenic H5N1 virus...
  17. ncbi Respiratory viruses predisposing to bacterial infections: role of neuraminidase
    Ville T Peltola
    Department of Infectious Diseases, St Judes Children s Research Hospital, Memphis, TN, USA
    Pediatr Infect Dis J 23:S87-97. 2004
    ..This article focuses on viral and bacterial combinations, particularly synergism between influenza and Streptococcus pneumoniae...
  18. ncbi Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
    ..agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family...
  19. ncbi Progressive ordering with decreasing temperature of the phospholipids of influenza virus
    Ivan V Polozov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, 10D14, 10 Center Drive MSC 1855, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 4:248-55. 2008
    ..Viral fusion appears to be uncorrelated to ordered lipid content. Lipid ordering may contribute to viral stability at lower temperatures, which has recently been found to be critical for airborne transmission...
  20. pmc Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection
    Hailong Guo
    Department of Microbiology and Immunology and David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, New York 14642, USA
    J Virol 84:7750-9. 2010
    ..Our data suggest that during primary respiratory viral infection, IL-22 seems to a play a marginal role for protection, indicating a differential requirement of this cytokine for bacterial and viral infections...
  21. pmc Endocytosis of influenza viruses
    Melike Lakadamyali
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street Naito Building, Cambridge, MA 02138, USA
    Microbes Infect 6:929-36. 2004
    ..Developments in real-time imaging of single viruses as well as the use of dominant-negative mutants to selectively block specific endocytic pathways have improved our understanding of the influenza infection process...
  22. ncbi Global epidemiology of influenza: past and present
    N J Cox
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Med 51:407-21. 2000
    ..Although many questions remain, advances of the past two decades have demonstrated that several widely held concepts concerning the global epidemiology of influenza were false...
  23. ncbi Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    Manfred Kopf
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nat Med 8:373-8. 2002
    ..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
  24. pmc Influenza virus directly infects human natural killer cells and induces cell apoptosis
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 83:9215-22. 2009
    ....
  25. ncbi Does this patient have influenza?
    Stephanie A Call
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    JAMA 293:987-97. 2005
    ..Making a reliable, rapid clinical diagnosis is essential to appropriate patient management that may be especially important during shortages of antiviral agents caused by high demand...
  26. ncbi Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany
    J Leukoc Biol 92:75-82. 2012
    ..Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury...
  27. ncbi Structural and genetic basis for development of broadly neutralizing influenza antibodies
    Daniel Lingwood
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
    Nature 489:566-70. 2012
    ..The data further suggest that selected immunoglobulin genes recognize specific protein structural 'patterns' that provide a substrate for further affinity maturation...
  28. pmc Functional motions of influenza virus hemagglutinin: a structure-based analytical approach
    Basak Isin
    Polymer Research Center and Chemical Engineering Department, Bogazici University, Bebek 80815, Istanbul, Turkey
    Biophys J 82:569-81. 2002
    ..The analysis of kinetically hot residues, in contrast, reveals a localization of energy centered around the HA2 residue Asp112, which apparently triggers the solvent exposure of the fusion peptide...
  29. ncbi Risk factors and viruses associated with hospitalization due to lower respiratory tract infections in Canadian Inuit children : a case-control study
    Anna Banerji
    Department of Pediatrics and Dalla Lana School of Public Health, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 28:697-701. 2009
    ..To examine risk factors for lower respiratory tract infections (LRTI) hospital admission in the Canadian Arctic...
  30. ncbi Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity
    Alexandre V Machado
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270 910, MG, Brazil
    Vaccine 28:3247-56. 2010
    ..gondii, they displayed up to 85% of reduction in parasite burden. These results demonstrate the potential use of recombinant influenza vectors harboring the dicistronic segments in the development of vaccines against infectious diseases...
  31. pmc Innate immune evasion strategies of influenza viruses
    Benjamin G Hale
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Future Microbiol 5:23-41. 2010
    ..The molecular details of this virus-host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirals are discussed...
  32. ncbi Potential role of human challenge studies for investigation of influenza transmission
    Ben Killingley
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    Lancet Infect Dis 11:879-86. 2011
    ....
  33. pmc Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein
    J Pavlovic
    Institut für Immunologie und Virologie, Universitat Zurich, Switzerland
    J Virol 64:3370-5. 1990
    ....
  34. ncbi Critical role of natural killer cells in lung immunopathology during influenza infection in mice
    Mohamed F Abdul-Careem
    McMaster Immunology Research Centre and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    J Infect Dis 206:167-77. 2012
    ..1(+) cell-depleted wild-type mice than in that from control mice. Our data suggest that NK cells significantly augment pulmonary inflammation, contributing to the pathogenesis of influenza infection...
  35. pmc Influenza activity in Europe during eight seasons (1999-2007): an evaluation of the indicators used to measure activity and an assessment of the timing, length and course of peak activity (spread) across Europe
    John Paget
    Netherlands Institute for Health Services Research NIVEL, PO Box 1568, 3500BN, Utrecht, The Netherlands
    BMC Infect Dis 7:141. 2007
    ..1) are the sentinel clinical reports a good measure of influenza activity? 2) how long is a typical influenza season in Europe? 3) is there a west-east and/or south-north course of peak activity ('spread') of influenza in Europe?..
  36. pmc Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin
    Samuel T Hess
    Laboratory for Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:965-76. 2005
    ..This work rules out the tested hypothesis for HA over the accessible length scales, yet shows clearly how the spatial distribution of HA depends on lipid composition...
  37. ncbi Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins
    Eugenia Leikina
    Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1855, USA
    Nat Immunol 6:995-1001. 2005
    ..This general mechanism might explain the broad-spectrum antiviral activity of many multivalent lectins of the innate immune system...
  38. pmc Influenza virus morphogenesis and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Virus Res 143:147-61. 2009
    Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to Orthomyxoviridae family...
  39. pmc Structural characterization of an early fusion intermediate of influenza virus hemagglutinin
    Rui Xu
    Department of Molecular Biology, BCC 206, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:5172-82. 2011
    ..Thus, our study reveals the possible initial structural event that leads to release of the B loop from its prefusion conformation, which is aided by unexpected structural changes within the membrane-distal HA1 domain at low pH...
  40. ncbi Active NF-kappaB signalling is a prerequisite for influenza virus infection
    Falk Nimmerjahn
    Klinische Kooperationsgruppe, Pädiatrische Tumorimmunologie, Kinderklinik, Universitätsklinikum der Technischen Universität München, Marchioninistr 25, D 81377 Munchen, Germany
    J Gen Virol 85:2347-56. 2004
    ..These results might be of major importance for both the development of new antiviral therapies and the understanding of influenza virus biology...
  41. pmc Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle
    J Pavlovic
    Institute for Immunology and Virology, University of Zurich, Switzerland
    J Virol 66:2564-9. 1992
    ....
  42. pmc Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
    W Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 193:1319-26. 2001
    ..These findings indicate that in addition to their effects on the presentation of foreign antigens, immunoproteasomes influence T(CD8+) responses by modifying the repertoire of responding T(CD8+)...
  43. pmc Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit
    Thibaut Crepin
    UJF EMBL CNRS, UMI 3265, Unit of Virus Host Cell Interactions, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9, France
    J Virol 84:9096-104. 2010
    ..Our results validate the use of the isolated endonuclease domain in a drug-design process for new anti-influenza virus compounds...
  44. pmc In vitro and in vivo activities of anti-influenza virus compound T-705
    Y Furuta
    Research Laboratories, Toyama Chemical Co, Ltd, 2 4 1 Shimookui, Toyama, Japan
    Antimicrob Agents Chemother 46:977-81. 2002
    ....
  45. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
  46. ncbi Prospects for controlling future pandemics of influenza
    James S Robertson
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK
    Virus Res 162:39-46. 2011
    ..There needs to be a continued focus on improvement to the vaccine response system that will require close collaboration between influenza and vaccine experts, manufacturers, regulators and public health authorities around the world...
  47. ncbi Mucosal IgA responses in influenza virus infections; thoughts for vaccine design
    Elly van Riet
    Influenza Virus Research Centre, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Vaccine 30:5893-900. 2012
    ..Here, the current knowledge on the induction of IgA, the role of influenza specific IgA producing B-cells in anti-influenza immunity as well as the role of humoral memory responses induced upon vaccination will be reviewed...
  48. ncbi The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytes
    Natalija Budimir
    Department of Medical Microbiology, Molecular Virology Section, University Medical Center and University of Groningen, Groningen, The Netherlands
    Vaccine 28:8280-7. 2010
    ..However, for optimal priming of naive CTLs these mechanisms should be complemented by delivery of antigen to the cytosol mediated by the membrane fusion capacity of the WIV particles...
  49. pmc Uncovering the global host cell requirements for influenza virus replication via RNAi screening
    Silke Stertz
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Microbes Infect 13:516-25. 2011
    ....
  50. pmc Protective cellular responses elicited by vaccination with influenza nucleoprotein delivered by a live recombinant attenuated Salmonella vaccine
    Shamaila Ashraf
    The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287 5401, USA
    Vaccine 29:3990-4002. 2011
    ..To conclude, we showed that Salmonella can be designed to deliver antigen(s) to the host cell cytosol for presumably class I presentation for the induction of protective immune responses...
  51. ncbi Selective and quantitative detection of influenza virus proteins in commercial vaccines using two-dimensional high-performance liquid chromatography and fluorescence detection
    Virginia García-Cañas
    Centre for Biologics Research, Health Canada, Banting Building, Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Anal Chem 79:3164-72. 2007
    ..In addition, it allowed the selective detection of several influenza constituents including nucleoproteins from type A and B viruses and the highly hydrophobic matrix protein 1 from both virus strains...
  52. pmc Differential recruitment of dendritic cells and monocytes to respiratory mucosal sites in children with influenza virus or respiratory syncytial virus infection
    Michelle A Gill
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Infect Dis 198:1667-76. 2008
    ..Although there are important differences in the immunopathogenesis of these 2 viral pathogens, little is known about how they affect antigen-presenting cells in children with acute infections...
  53. pmc The host interactome of influenza virus presents new potential targets for antiviral drugs
    Megan L Shaw
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Med Virol 21:358-69. 2011
    ....
  54. pmc The final conformation of the complete ectodomain of the HA2 subunit of influenza hemagglutinin can by itself drive low pH-dependent fusion
    Chang Sup Kim
    Department of Biotechnology, Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 305 719, South Korea
    J Biol Chem 286:13226-34. 2011
    ....
  55. ncbi A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection
    D F Johnson
    Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
    Clin Infect Dis 49:275-7. 2009
    ..Of 26 patients with a clinical diagnosis of influenza, 19 had the diagnosis confirmed by RT-PCR, and 9 went on to complete the study. Surgical and N95 masks were equally effective in preventing the spread of PCR-detectable influenza...
  56. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  57. pmc Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8+ T cells against Trypanosoma cruzi infection
    Eiji Takayama
    Department of Global Infectious Diseases and Tropical Medicine, National Defense Medical College, Tokorozawa City, Saitama, Japan
    Int J Parasitol 40:1549-61. 2010
    ....
  58. ncbi Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
    Oleg P Zhirnov
    D I Ivanovsky Institute of Virology, Moscow 123098, Russia
    Apoptosis 12:1419-32. 2007
    ....
  59. pmc Immunogenicity of three different influenza vaccines against homologous and heterologous strains in nursing home elderly residents
    Vincenzo Baldo
    Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via Loredan 18, 35151 Padua, Italy
    Clin Dev Immunol 2010:517198. 2010
    ....
  60. pmc Surveillance of respiratory virus infections in adult hospital admissions using rapid methods
    M Kaye
    Microbiology Department, The Shrewsbury and Telford Hospital NHS Trust, Telford, Shropshire, UK
    Epidemiol Infect 134:792-8. 2006
    ..The molecular methods used in this study showed that surveillance of these respiratory viruses can be conducted and may help in the management of patients...
  61. ncbi Role of hemagglutinin cleavage for the pathogenicity of influenza virus
    D A Steinhauer
    National Institute for Medical Research, The Ridgeway, London, Mill Hill, NW7 1AA, United Kingdom
    Virology 258:1-20. 1999
    ..Here influenza virus pathogenicity is discussed, with an emphasis on the role of HA0 cleavage as a determining factor...
  62. ncbi Occurrence of respiratory virus: time, place and person
    Arnold S Monto
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
    Pediatr Infect Dis J 23:S58-64. 2004
    ....
  63. pmc Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus
    Kelly K Lee
    Department of Medicinal Chemistry and Biomolecular Structure and Design Program, University ofWashington, Seattle, Washington 98195, USA
    J Biol Chem 286:42141-9. 2011
    ..These results provide proof of concept for an antiviral strategy that is applicable to intracellularly fusing viruses, including known and emerging viral pathogens...
  64. ncbi Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection
    Vilma Decman
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 184:5151-9. 2010
    ..Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity...
  65. pmc The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae
    B Krossøy
    Department of Fisheries and Marine Biology, University of Bergen, Bergen, Norway
    J Virol 73:2136-42. 1999
    ..regions of other segmented negative-stranded RNA viruses shows a closer relationship with members of the Orthomyxoviridae than with viruses in other families...
  66. pmc Evaluation of an influenza-like illness case definition in the diagnosis of influenza among patients with acute febrile illness in Cambodia
    Matthew R Kasper
    U S Naval Medical Research Unit 2, Jakarta, Indonesia
    BMC Infect Dis 10:320. 2010
    ..0°C) with cough or sore throat. In this study, we tested the sensitivity, specificity, and positive and negative predictive values of this case definition in a Cambodia patient population...
  67. pmc Airborne influenza virus detection with four aerosol samplers using molecular and infectivity assays: considerations for a new infectious virus aerosol sampler
    P Fabian
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Indoor Air 19:433-41. 2009
    ..As a first step in designing a new air sampler to collect influenza virus we evaluated four commercial samplers and determined necessary design parameters for a new collector...
  68. pmc Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein
    Gallen B Triana-Baltzer
    NexBio Inc, San Diego, CA, USA
    PLoS ONE 4:e7838. 2009
    ..DAS181 inhibits IFV that is resistant to NAIs. Thus, DAS181 may offer an alternative therapeutic option for seasonal or pandemic IFVs that become resistant to currently available antiviral drugs...
  69. pmc Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus
    Chen Chen
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:11790-5. 2008
    ..These results suggest that epsin 1 functions as a cargo-specific adaptor for the clathrin-mediated entry of the influenza virus...
  70. pmc Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus
    C R Baskin
    Department of Comparative Medicine, University of Washington, Seattle, Washington 981951, USA
    J Virol 81:11817-27. 2007
    ..This protection was achieved in the absence of significant or long-lasting adverse effects and through induction of a robust adaptive immune response...
  71. ncbi Towards an atomic resolution understanding of the influenza virus replication machinery
    Rob W H Ruigrok
    Unit of Virus Host Cell Interactions, UJF EMBL CNRS, UMI 3265, Grenoble, France
    Curr Opin Struct Biol 20:104-13. 2010
    ..These results provide the first detailed structure-function insights into polymerase assembly, transcription and host adaptation and will have an impact on anti-influenza drug design...
  72. ncbi Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children
    T G Boyce
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Vaccine 18:82-8. 1999
    ..015). Two doses of CAIV-T induce a mucosal IgA response to all three influenza vaccine antigens in the majority of children. In addition, a mucosal antibody response may be the only indication of a vaccine take in a seropositive child...
  73. pmc Antiviral instruction of bone marrow leukocytes during respiratory viral infections
    Tamar Hermesh
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Host Microbe 7:343-53. 2010
    ..These findings show that appropriate instruction of cells during their development in the bone marrow is needed for effective control of infection...
  74. ncbi Respiratory viruses detected in hospitalised paediatric patients with respiratory infections
    S Zamberi
    Department of Clinical Laboratory Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor
    Med J Malaysia 58:681-7. 2003
    ..4%) and croup (27%). Viral aetiologies were confirmed in 23.4% of the patients. The most common respiratory virus isolated or detected was RSV, followed by parainfluenza viruses, influenza viruses and adenovirus...
  75. pmc Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: implications for disparate immune system priming pathways
    William A Langley
    Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    J Virol 84:8300-7. 2010
    ..In some cases, such toxin-neutralizing activity was notably high, indicating that the mechanisms by which immunity is primed by live influenza virus vectors may have beneficial properties...
  76. pmc Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    Melike Lakadamyali
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Cell 124:997-1009. 2006
    ..This pre-early endosome sorting process begins at clathrin-coated vesicles, depends on microtubule-dependent motility, and appears to involve endocytic adaptors...
  77. pmc Influenza virus NS vectors expressing the mycobacterium tuberculosis ESAT-6 protein induce CD4+ Th1 immune response and protect animals against tuberculosis challenge
    Sabine Sereinig
    Institute of Applied Microbiology, Muthgasse 18, 1190 Vienna, Austria
    Clin Vaccine Immunol 13:898-904. 2006
    ..tuberculosis-specific Th1 immune response in mice. Moreover, intranasal immunization of mice and guinea pigs with such vectors induced protection against mycobacterial challenge, similar to that induced by BCG vaccination...
  78. pmc Minimum molecular architectures for transcription and replication of the influenza virus
    Ayae Honda
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Proc Natl Acad Sci U S A 99:13166-71. 2002
    ..Taken together we propose that the catalytic specificity of PB1 subunit is modulated to the transcriptase by binding PB2 or the replicase by interaction with PA...
  79. ncbi Predicting influenza infections during epidemics with use of a clinical case definition
    G Boivin
    Research Center in Infectious Diseases and Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Clin Infect Dis 31:1166-9. 2000
    ..8%, 39.3%, 77.6%, and 55.0%, respectively...
  80. ncbi Patterns of influenza-associated mortality among US elderly by geographic region and virus subtype, 1968-1998
    Sharon K Greene
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Am J Epidemiol 163:316-26. 2006
    ..23, standard deviation = 0.058). These novel analyses suggest that causes of spatial heterogeneity (e.g., large-scale environmental drivers and population movement) have impacted influenza-associated mortality...
  81. ncbi Host factor Ebp1: selective inhibitor of influenza virus transcriptase
    Ayae Honda
    Department of Frontier Bioscience and Micro Nano Technology Research Center, Hosei University, Koganei, Tokyo 184 8584, Japan
    Genes Cells 12:133-42. 2007
    ....
  82. pmc Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use
    Arnold S Monto
    University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Antimicrob Agents Chemother 50:2395-402. 2006
    ..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use...
  83. pmc Visualizing infection of individual influenza viruses
    Melike Lakadamyali
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:9280-5. 2003
    ..This finding suggests a previously undescribed scenario of the endocytic pathway toward late endosomes: endosome maturation, including initial acidification, largely occurs in the perinuclear region...
  84. ncbi Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection
    Filippo Ansaldi
    Department of Health Sciences, University of Genoa CIRI IV, Inter University Research Centre on Influenza, Via Pastore 1, 16132 Genoa, Italy
    Vaccine 27:3345-8. 2009
    ..Promising results were obtained using a new generation of oil-in-water emulsion adjuvants, named AS, offering cross-protection against heterologous challenge in ferrets...
  85. pmc Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure
    Alexandre Harari
    Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Virol 83:2862-71. 2009
    ..These results advance our understanding of the relationship between distinct profiles of cytotoxic granules in memory CD8 T cells and function, differentiation stage, and antigen exposure...
  86. ncbi Altered peptidase and viral-specific T cell response in LMP2 mutant mice
    L van Kaer
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 1:533-41. 1994
    ..These findings indicate that LMP2 influences antigen processing...
  87. ncbi Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lung
    Godelieve J de Bree
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 195:1718-25. 2007
    ..We investigated CD4(+) memory T cell responses to influenza virus (FLU), respiratory syncytial virus (RSV), and nontypeable Haemophilus influenzae (NTHi)...
  88. ncbi Role of host protein Ebp1 in influenza virus growth: intracellular localization of Ebp1 in virus-infected and uninfected cells
    Ayae Honda
    Department of Frontier Bioscience and Micro Nano Technology Research Center, Hosei University, Koganei, Tokyo, Japan
    J Biotechnol 133:208-12. 2008
    ..Ebp1 was found to localize in the nuclear membrane of uninfected cells, and to form nuclear aggregates with viral P proteins in virus-infected cells...
  89. ncbi Antigen-based assays for the identification of influenza virus and respiratory syncytial virus: why and how to use them in pediatric practice
    Nicola Principi
    Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milano, Italy
    Clin Lab Med 29:649-60. 2009
    ..The most recently marketed tests are similarly effective in identifying viruses, and so pediatricians should choose those that are less expensive, less time consuming, and easier to perform and to interpret...
  90. ncbi A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B
    Catherine Ewen
    Department of Biochemistry, University of Alberta, 463 Medical Sciences Bldg, T6G 2H7, Edmonton, Alberta, Canada
    J Immunol Methods 276:89-101. 2003
    ..The novel cytotoxic assay presented here should give investigators a sensitive, cross-species, nonradioactive alternative to 51Cr-release assays as a means to assess antigen-specific CTL responses in vaccine trials...
  91. pmc Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms
    K Ghoshal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, 333 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
    Mol Cell Biol 21:8301-17. 2001
    ..These results have demonstrated that MT-I and MT-II can be induced robustly in the liver and lung following experimental influenza virus infection by overlapping but distinct molecular mechanisms...
  92. ncbi Working towards a simple case definition for influenza surveillance
    Karin Thursky
    Victorian Infectious Diseases Reference Laboratory, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia
    J Clin Virol 27:170-9. 2003
    ..A single definition of influenza-like illness (ILI) has been recommended by the Australian Influenza Pandemic planning committee for influenza surveillance systems throughout Australia...
  93. pmc Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:233-8. 2001
    ..These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity...
  94. ncbi Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal mice
    Mehran Haidari
    University of Texas Health Science Center at Houston, Houston, TX, USA
    Atherosclerosis 208:90-6. 2010
    ..We assessed the vascular effects of influenza infection and whether the virus can directly infect atherosclerotic arteries in mice...
  95. pmc Influenza vaccines: present and future
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Clin Invest 110:9-13. 2002
  96. ncbi Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
    Franck Tarendeau
    European Molecular Biology Laboratory EMBL Grenoble Outstation, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
    Nat Struct Mol Biol 14:229-33. 2007
    ..The domain contains three surface residues implicated in adaptation from avian to mammalian hosts. One of these tethers the NLS-containing peptide to the core of the domain in the unbound state...
  97. pmc Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza
    Javier Rangel-Moreno
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 104:10577-82. 2007
    ..These results demonstrate that the local expression of homeostatic chemokines in nonlymphoid organs, such as the lung, plays an important role in protective immune responses...
  98. ncbi Role of apoptosis and cytokines in influenza virus morbidity
    Edward W A Brydon
    Department of Microbiology, New York, NY 100029 6574, USA
    FEMS Microbiol Rev 29:837-50. 2005
    ....
  99. ncbi CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:2888-98. 2006
    ....
  100. ncbi The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication
    Agustín Portela
    División de Productos Biológicos y Biotecnología, Agencia Española del Medicamento, Majadahonda 28220, Madrid, Spain
    J Gen Virol 83:723-34. 2002
    ..The evidence for the existence of each of these activities and their possible roles in transcription, replication and intracellular trafficking of the virus genome is considered...
  101. pmc Estimation of influenza vaccine effectiveness from routine surveillance data
    Heath Kelly
    Epidemiology Unit and Virus Identification Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia
    PLoS ONE 4:e5079. 2009
    ..It is possible to use a case control method to estimate vaccine effectiveness from surveillance data when all patients in a surveillance system are tested for influenza and their vaccination status is known...

Research Grants70

  1. The influenza A virus nucleoprotein: structure and function
    Yizhi Jane Tao; Fiscal Year: 2012
    ..B virus and determine whether NP self-oligomerization and RNA binding modes are broadly conserved in the Orthomyxoviridae family. 2. Elucidate the role of NP in viral RNA replication...
  2. 6th Orthomyxovirus Research Conference
    STACEY L SCHULTZ-CHERRY; Fiscal Year: 2012
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  3. Pathogenic determinants of an emerging infectious disease
    James K Jancovich; Fiscal Year: 2012
    ....
  4. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..1. To test retrocyclins against potential viral bioterrorism agents, including Influenza A and B (Orthomyxoviridae), HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia ..
  5. INFLUENZA B VIRUS AND MATRIX GENE ORF
    DAN DEBORDE; Fiscal Year: 1990
    Influenza A and B viruses are both members of the genus Influenzavirus of the Family Orthomyxoviridae, and as such are closely related in genome, structure, and pathogenicity...
  6. Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample prepar
    Darrell Chandler; Fiscal Year: 2007
    ..Influenza viruses are highly contagious, segmented negative-sense RNA viruses that belong to the family Orthomyxoviridae, causing approximately 114,000 hospitalizations and 20,000 deaths annually...
  7. GLYCOCONJUGATES IN VIRAL PATHOGENESIS
    GILLIAN AIR; Fiscal Year: 2007
    ..abstract_text> ..
  8. Investigation of influenza virulence mediated by the NS1A protein
    DIANA NOAH; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Influenza viruses (Orthomyxoviridae family) cause a highly contagious respiratory disease in humans resulting in approximately 36,000 deaths in the United States annually...
  9. 4th Orthomyxovirus Research Conference
    Stacey Schultz Cherry; Fiscal Year: 2007
    ..The purpose[unreadable] of this proposal is to provide funds that will allow promising young investigators to[unreadable] interact with their peers and develop a commitment to this area of research. ..
  10. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 1993
    ..These experiments would enable us to define the function of individual P proteins and the locatio of critical domain(s) and site(s) in the RNA and proteins involved in transcription and replication...
  11. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  12. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  13. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  14. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  15. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  16. Novel broad spectrum vaccination against influenza
    Petr Ilyinskii; Fiscal Year: 2006
    ..The overall aim of this project is to demonstrate better protective effect or/and enhanced immune response using modified influenza proteins as immunogens compared to wild-type viral proteins. ..
  17. Modification of Conserved Influenza Genes Enabling their Elevated Expression
    Petr Ilyinskii; Fiscal Year: 2008
    ..Therefore, if proven, our approach will lead to a novel paradigm for recombinant gene modifications for enhanced expression in vivo, both for vaccine and non-vaccine applications. [unreadable] [unreadable] [unreadable]..
  18. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  19. Alphavirus-based Vaccine for Prevention of MPV Infection
    James Crowe; Fiscal Year: 2008
    ..The consortium submitting this application brings together an experienced investigator group with expertise in pneumovirus and alphavirus virology, immunology, and vaccine development. ..
  20. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  21. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 2007
    ..abstract_text> ..
  22. The Role of the RET Receptor in Autoimmune Disease
    Laurence Eisenlohr; Fiscal Year: 2007
    ..By deciphering the role of RETECD antibody in disease, we can design improved methods and drugs for the abrogation of thyroid and other organ-specific autoimmune disorders. [unreadable] [unreadable] [unreadable]..
  23. Mechanisms of influenza NA drug resistance
    Jennifer L McKimm Breschkin; Fiscal Year: 2010
    ....
  24. RESPIRATORY VIRUS ION CHANNELS
    LAWRENCE PINTO; Fiscal Year: 2007
    ..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
  25. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  26. The Basis for MHC Class II-restricted proteasome-dependent epitopes
    LAURENCE CRANE EISENLOHR; Fiscal Year: 2010
    ..Execution of the plan could fundamentally alter the general perception of CD4+ T cell responses and the roles they play in protection, thereby strongly influencing the design of future vaccines. ..
  27. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  28. The impact of the pneumococcal conjugate vaccine on pneumonia hospitalizations
    CARLOS GRIJALVA; Fiscal Year: 2008
    ..We propose the use of NIS and SID for the evaluation of the pneumococcal conjugate vaccination program, using an innovative approach. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  30. Class II Processing Delineated by Flu Glycoproteins
    Laurence Eisenlohr; Fiscal Year: 2008
    ..abstract_text> ..
  31. Reducing Transmission of Influenza by Face Masks
    ARNOLD MONTO; Fiscal Year: 2008
    ..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
  32. Dissecting 3 processing pathways that generate class II-restricted flu epitopes
    Laurence Eisenlohr; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Respiratory Syncytial Virus Nanoparticle Vaccines
    James Crowe; Fiscal Year: 2008
    ..The development of a new technology for vaccination using nanoparticles also could have wide impact, since such a vaccine technology might be useful in developing vaccines against other infections. [unreadable] [unreadable] [unreadable]..
  34. Studies on Influenza B Virus BM2 Protein Ion Channel
    LAWRENCE PINTO; Fiscal Year: 2009
    ....
  35. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
    ..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
  36. Nutrition, Viral Mutation and Host Defense
    Melinda Beck; Fiscal Year: 2007
    ..abstract_text> ..
  37. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
    ..abstract_text> ..
  38. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  39. ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANS
    James Crowe; Fiscal Year: 2001
    ..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
  40. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  41. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  42. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2002
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  43. High Throughput Flow Cytometry Sorter
    James Crowe; Fiscal Year: 2004
    ..The requested instrument will meet all of these demonstrated needs. ..
  44. TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPY
    Adolfo Garcia Sastre; Fiscal Year: 2002
    ..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..
  45. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  46. IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORY
    Laurence Eisenlohr; Fiscal Year: 2003
    ..He believes that the pursuit of these aims will provide fundamentally important information about TCD8+-mediated immunity and will put us in a strong position to address the next generation of questions that will be facing the field. ..
  47. HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIA
    James Crowe; Fiscal Year: 2002
    ..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..
  48. Human T Cells Responses to RSV
    James Crowe; Fiscal Year: 2006
    ..abstract_text> ..
  49. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  51. The Role of Nutrition in Virus-Induced Optic Neuropathy
    Melinda Beck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. INFLUENZA VIRUS RIBONUCLEOPROTEINS (RNP)
    Peter Palese; Fiscal Year: 2006
    ..abstract_text> ..
  53. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  54. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  55. Comparative Study of Influenza Vaccines in Adults
    ARNOLD MONTO; Fiscal Year: 2006
    ..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
  56. Virulence factors of influenza virus: The NS1 protein
    Adolfo Garcia Sastre; Fiscal Year: 2010
    ..abstract_text> ..
  57. Novel methods for generation of human B cell hybridomas
    James Crowe; Fiscal Year: 2005
    ..abstract_text> ..
  58. Human Antibody Responses to Rotavirus
    James Crowe; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Cell-Mediated Immune Responses to Vaccinia Viruses
    James Crowe; Fiscal Year: 2006
    ..We will examine many of these questions by taking advantage of new technology that allows for examination of T cell responses at the single cell level, and in an immunodominant epitope specific manner. [unreadable] [unreadable]..
  60. Immunomodulation on the Nanoscale (RMI)
    James Crowe; Fiscal Year: 2004
    ..Immunology and infectious diseases. 2. Materials science, especially nanoparticles, nanowires, and nanofluidics. 3. Instrumented platforms for cellular imaging and control. 4. Biocomputing. ..
  61. The Influence of Nutrition on Influenza Virus Infection
    Melinda Beck; Fiscal Year: 2004
    ..abstract_text> ..
  62. CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 2005
    ..A detailed understanding of these processes will facilitate the rational development of antiviral agents which could interfere with one or more steps in virus assembly. ..
  63. Development of Guinea Pig as Mamalian for Influenza Virus Transmission
    Peter Palese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  64. Rapid Vaccine Development System
    Gary Fujii; Fiscal Year: 2002
    ..Evaluation of the anthrax antigen liposomes in preclinical animal models will be conducted in the Phase II studies. ..
  65. Non-Viral Pandemic Influenza Vaccine Development
    Gary Fujii; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  66. Development of an Aspergillus Vaccine
    Gary Fujii; Fiscal Year: 2008
    ..Thus, a safe and effective vaccine against A. fumigatus would save health care dollars (and have significant dollar value) and, most importantly, save lives. [unreadable] [unreadable] [unreadable]..
  67. Liposomal Adjuvant for Vaccine Development
    Gary Fujii; Fiscal Year: 2008
    ..Moreover, liposomal formulations might also be discovered that could be developed into the next generation anthrax vaccine. [unreadable] [unreadable] [unreadable]..
  68. Genital Herpes Vaccine Discovery
    Gary Fujii; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  69. Alteration of Human Dendritic Cell Subsets by RSV
    Michelle Gill; Fiscal Year: 2008
    ..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..