Genomes and Genes
Summary: A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.
Publications251 found, 100 shown here
- Absolute humidity modulates influenza survival, transmission, and seasonalityJeffrey Shaman
College of Oceanic and Atmospheric Sciences, Oregon State University, Corvallis, OR 97331, USA
Proc Natl Acad Sci U S A 106:3243-8. 2009..This hypothesis can be further tested through future, additional laboratory, epidemiological and modeling studies...
- Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cellsO Mandelboim
The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
Nature 409:1055-60. 2001..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
- The influenza virus resource at the National Center for Biotechnology InformationYiming Bao
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
J Virol 82:596-601. 2008
- Measurements of airborne influenza virus in aerosol particles from human coughsWilliam G Lindsley
Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
PLoS ONE 5:e15100. 2010..Further research is needed on the viability of airborne influenza viruses and the risk of transmission...
- Recognition of viral hemagglutinins by NKp44 but not by NKp30T I Arnon
The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Eur J Immunol 31:2680-9. 2001..221 cells expressing MHC class I proteinsresulted in the abrogation of the inhibition by NK clones expressing high levels of NKp44. In addition, the binding of NKp44 to HA improves the ability of some NK clones to lyse IV infected cells...
- Influenza virus in human exhaled breath: an observational studyPatricia Fabian
Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
PLoS ONE 3:e2691. 2008..Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection...
- Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responsesTimothy P Welliver
MedImmune, Inc, Gaithersburg, MD, USA
J Infect Dis 195:1126-36. 2007..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
- Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infectionNicole Schmitz
Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
J Virol 79:6441-8. 2005..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
- Recognition of single-stranded RNA viruses by Toll-like receptor 7Jennifer M Lund
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 101:5598-603. 2004..These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens...
- Measurement of airborne influenza virus in a hospital emergency departmentFrancoise M Blachere
Division of Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Clin Infect Dis 48:438-40. 2009..Our results provide evidence that influenza virus may spread through the airborne route...
- Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virusBalaji Manicassamy
Department of Microbiology, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 107:11531-6. 2010....
- The epidemiology and evolution of influenza viruses in pigsI H Brown
Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK
Vet Microbiol 74:29-46. 2000..Both human H3N2 and avian H1N1 were detected in pigs many years before they acquired the ability to spread rapidly and become associated with disease epidemics in pigs...
- Influenza virus entry and infection require host cell N-linked glycoproteinVictor C Chu
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 101:18153-8. 2004..We suggest that influenza virus specifically requires N-linked glycoprotein for entry into cells, and that sialic acid, although acting as an efficient attachment factor, is not sufficient as an influenza virus receptor in vivo...
- Transmission of influenza virus via aerosols and fomites in the guinea pig modelSamira Mubareka
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Infect Dis 199:858-65. 2009..The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission...
- TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cellsStephanie Bertram
Institute of Virology, Hannover Medical School, 30625 Hannover, Germany
J Virol 84:10016-25. 2010..Collectively, our results point toward an important role for TMPRSS2 and possibly TMPRSS4 in influenza virus replication and highlight the former protease as a potential therapeutic target...
- Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccineDavide Corti
Institute for Research in Biomedicine, Bellinzona, Switzerland
J Clin Invest 120:1663-73. 2010..These findings reveal that seasonal influenza vaccination can induce polyclonal heterosubtypic neutralizing antibodies that cross-react with the swine-origin pandemic H1N1 influenza virus and with the highly pathogenic H5N1 virus...
- Respiratory viruses predisposing to bacterial infections: role of neuraminidaseVille T Peltola
Department of Infectious Diseases, St Judes Children s Research Hospital, Memphis, TN, USA
Pediatr Infect Dis J 23:S87-97. 2004..This article focuses on viral and bacterial combinations, particularly synergism between influenza and Streptococcus pneumoniae...
- Assembly and budding of influenza virusDebi P Nayak
Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Virus Res 106:147-65. 2004..agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family...
- Progressive ordering with decreasing temperature of the phospholipids of influenza virusIvan V Polozov
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, 10D14, 10 Center Drive MSC 1855, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Chem Biol 4:248-55. 2008..Viral fusion appears to be uncorrelated to ordered lipid content. Lipid ordering may contribute to viral stability at lower temperatures, which has recently been found to be critical for airborne transmission...
- Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infectionHailong Guo
Department of Microbiology and Immunology and David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, New York 14642, USA
J Virol 84:7750-9. 2010..Our data suggest that during primary respiratory viral infection, IL-22 seems to a play a marginal role for protection, indicating a differential requirement of this cytokine for bacterial and viral infections...
- Endocytosis of influenza virusesMelike Lakadamyali
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street Naito Building, Cambridge, MA 02138, USA
Microbes Infect 6:929-36. 2004..Developments in real-time imaging of single viruses as well as the use of dominant-negative mutants to selectively block specific endocytic pathways have improved our understanding of the influenza infection process...
- Global epidemiology of influenza: past and presentN J Cox
Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Annu Rev Med 51:407-21. 2000..Although many questions remain, advances of the past two decades have demonstrated that several widely held concepts concerning the global epidemiology of influenza were false...
- Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infectionManfred Kopf
Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
Nat Med 8:373-8. 2002..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
- Influenza virus directly infects human natural killer cells and induces cell apoptosisHuawei Mao
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
J Virol 83:9215-22. 2009....
- Does this patient have influenza?Stephanie A Call
Department of Medicine, University of Louisville, Louisville, KY 40202, USA
JAMA 293:987-97. 2005..Making a reliable, rapid clinical diagnosis is essential to appropriate patient management that may be especially important during shortages of antiviral agents caused by high demand...
- Apoptosis signaling in influenza virus propagation, innate host defense, and lung injurySusanne Herold
University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany
J Leukoc Biol 92:75-82. 2012..Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury...
- Structural and genetic basis for development of broadly neutralizing influenza antibodiesDaniel Lingwood
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
Nature 489:566-70. 2012..The data further suggest that selected immunoglobulin genes recognize specific protein structural 'patterns' that provide a substrate for further affinity maturation...
- Functional motions of influenza virus hemagglutinin: a structure-based analytical approachBasak Isin
Polymer Research Center and Chemical Engineering Department, Bogazici University, Bebek 80815, Istanbul, Turkey
Biophys J 82:569-81. 2002..The analysis of kinetically hot residues, in contrast, reveals a localization of energy centered around the HA2 residue Asp112, which apparently triggers the solvent exposure of the fusion peptide...
- Risk factors and viruses associated with hospitalization due to lower respiratory tract infections in Canadian Inuit children : a case-control studyAnna Banerji
Department of Pediatrics and Dalla Lana School of Public Health, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Pediatr Infect Dis J 28:697-701. 2009..To examine risk factors for lower respiratory tract infections (LRTI) hospital admission in the Canadian Arctic...
- Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunityAlexandre V Machado
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270 910, MG, Brazil
Vaccine 28:3247-56. 2010..gondii, they displayed up to 85% of reduction in parasite burden. These results demonstrate the potential use of recombinant influenza vectors harboring the dicistronic segments in the development of vaccines against infectious diseases...
- Innate immune evasion strategies of influenza virusesBenjamin G Hale
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Future Microbiol 5:23-41. 2010..The molecular details of this virus-host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirals are discussed...
- Potential role of human challenge studies for investigation of influenza transmissionBen Killingley
Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
Lancet Infect Dis 11:879-86. 2011....
- Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA proteinJ Pavlovic
Institut für Immunologie und Virologie, Universitat Zurich, Switzerland
J Virol 64:3370-5. 1990....
- Critical role of natural killer cells in lung immunopathology during influenza infection in miceMohamed F Abdul-Careem
McMaster Immunology Research Centre and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
J Infect Dis 206:167-77. 2012..1(+) cell-depleted wild-type mice than in that from control mice. Our data suggest that NK cells significantly augment pulmonary inflammation, contributing to the pathogenesis of influenza infection...
- Influenza activity in Europe during eight seasons (1999-2007): an evaluation of the indicators used to measure activity and an assessment of the timing, length and course of peak activity (spread) across EuropeJohn Paget
Netherlands Institute for Health Services Research NIVEL, PO Box 1568, 3500BN, Utrecht, The Netherlands
BMC Infect Dis 7:141. 2007..1) are the sentinel clinical reports a good measure of influenza activity? 2) how long is a typical influenza season in Europe? 3) is there a west-east and/or south-north course of peak activity ('spread') of influenza in Europe?..
- Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutininSamuel T Hess
Laboratory for Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 169:965-76. 2005..This work rules out the tested hypothesis for HA over the accessible length scales, yet shows clearly how the spatial distribution of HA depends on lipid composition...
- Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteinsEugenia Leikina
Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1855, USA
Nat Immunol 6:995-1001. 2005..This general mechanism might explain the broad-spectrum antiviral activity of many multivalent lectins of the innate immune system...
- Influenza virus morphogenesis and buddingDebi P Nayak
Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Virus Res 143:147-61. 2009Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to Orthomyxoviridae family...
- Structural characterization of an early fusion intermediate of influenza virus hemagglutininRui Xu
Department of Molecular Biology, BCC 206, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 85:5172-82. 2011..Thus, our study reveals the possible initial structural event that leads to release of the B loop from its prefusion conformation, which is aided by unexpected structural changes within the membrane-distal HA1 domain at low pH...
- Active NF-kappaB signalling is a prerequisite for influenza virus infectionFalk Nimmerjahn
Klinische Kooperationsgruppe, Pädiatrische Tumorimmunologie, Kinderklinik, Universitätsklinikum der Technischen Universität München, Marchioninistr 25, D 81377 Munchen, Germany
J Gen Virol 85:2347-56. 2004..These results might be of major importance for both the development of new antiviral therapies and the understanding of influenza virus biology...
- Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycleJ Pavlovic
Institute for Immunology and Virology, University of Zurich, Switzerland
J Virol 66:2564-9. 1992....
- Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigensW Chen
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 193:1319-26. 2001..These findings indicate that in addition to their effects on the presentation of foreign antigens, immunoproteasomes influence T(CD8+) responses by modifying the repertoire of responding T(CD8+)...
- Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunitThibaut Crepin
UJF EMBL CNRS, UMI 3265, Unit of Virus Host Cell Interactions, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9, France
J Virol 84:9096-104. 2010..Our results validate the use of the isolated endonuclease domain in a drug-design process for new anti-influenza virus compounds...
- In vitro and in vivo activities of anti-influenza virus compound T-705Y Furuta
Research Laboratories, Toyama Chemical Co, Ltd, 2 4 1 Shimookui, Toyama, Japan
Antimicrob Agents Chemother 46:977-81. 2002....
- Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNAThirumala Devi Kanneganti
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:36560-8. 2006..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
- Prospects for controlling future pandemics of influenzaJames S Robertson
National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK
Virus Res 162:39-46. 2011..There needs to be a continued focus on improvement to the vaccine response system that will require close collaboration between influenza and vaccine experts, manufacturers, regulators and public health authorities around the world...
- Mucosal IgA responses in influenza virus infections; thoughts for vaccine designElly van Riet
Influenza Virus Research Centre, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
Vaccine 30:5893-900. 2012..Here, the current knowledge on the induction of IgA, the role of influenza specific IgA producing B-cells in anti-influenza immunity as well as the role of humoral memory responses induced upon vaccination will be reviewed...
- The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytesNatalija Budimir
Department of Medical Microbiology, Molecular Virology Section, University Medical Center and University of Groningen, Groningen, The Netherlands
Vaccine 28:8280-7. 2010..However, for optimal priming of naive CTLs these mechanisms should be complemented by delivery of antigen to the cytosol mediated by the membrane fusion capacity of the WIV particles...
- Uncovering the global host cell requirements for influenza virus replication via RNAi screeningSilke Stertz
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Microbes Infect 13:516-25. 2011....
- Protective cellular responses elicited by vaccination with influenza nucleoprotein delivered by a live recombinant attenuated Salmonella vaccineShamaila Ashraf
The Biodesign Institute, Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ 85287 5401, USA
Vaccine 29:3990-4002. 2011..To conclude, we showed that Salmonella can be designed to deliver antigen(s) to the host cell cytosol for presumably class I presentation for the induction of protective immune responses...
- Selective and quantitative detection of influenza virus proteins in commercial vaccines using two-dimensional high-performance liquid chromatography and fluorescence detectionVirginia García-Cañas
Centre for Biologics Research, Health Canada, Banting Building, Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
Anal Chem 79:3164-72. 2007..In addition, it allowed the selective detection of several influenza constituents including nucleoproteins from type A and B viruses and the highly hydrophobic matrix protein 1 from both virus strains...
- Differential recruitment of dendritic cells and monocytes to respiratory mucosal sites in children with influenza virus or respiratory syncytial virus infectionMichelle A Gill
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Infect Dis 198:1667-76. 2008..Although there are important differences in the immunopathogenesis of these 2 viral pathogens, little is known about how they affect antigen-presenting cells in children with acute infections...
- The host interactome of influenza virus presents new potential targets for antiviral drugsMegan L Shaw
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Rev Med Virol 21:358-69. 2011....
- The final conformation of the complete ectodomain of the HA2 subunit of influenza hemagglutinin can by itself drive low pH-dependent fusionChang Sup Kim
Department of Biotechnology, Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 305 719, South Korea
J Biol Chem 286:13226-34. 2011....
- A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infectionD F Johnson
Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
Clin Infect Dis 49:275-7. 2009..Of 26 patients with a clinical diagnosis of influenza, 19 had the diagnosis confirmed by RT-PCR, and 9 went on to complete the study. Surgical and N95 masks were equally effective in preventing the spread of PCR-detectable influenza...
- Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cellsCorine H GeurtsvanKessel
Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
J Exp Med 205:1621-34. 2008..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
- Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8+ T cells against Trypanosoma cruzi infectionEiji Takayama
Department of Global Infectious Diseases and Tropical Medicine, National Defense Medical College, Tokorozawa City, Saitama, Japan
Int J Parasitol 40:1549-61. 2010....
- Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signalingOleg P Zhirnov
D I Ivanovsky Institute of Virology, Moscow 123098, Russia
Apoptosis 12:1419-32. 2007....
- Immunogenicity of three different influenza vaccines against homologous and heterologous strains in nursing home elderly residentsVincenzo Baldo
Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via Loredan 18, 35151 Padua, Italy
Clin Dev Immunol 2010:517198. 2010....
- Surveillance of respiratory virus infections in adult hospital admissions using rapid methodsM Kaye
Microbiology Department, The Shrewsbury and Telford Hospital NHS Trust, Telford, Shropshire, UK
Epidemiol Infect 134:792-8. 2006..The molecular methods used in this study showed that surveillance of these respiratory viruses can be conducted and may help in the management of patients...
- Role of hemagglutinin cleavage for the pathogenicity of influenza virusD A Steinhauer
National Institute for Medical Research, The Ridgeway, London, Mill Hill, NW7 1AA, United Kingdom
Virology 258:1-20. 1999..Here influenza virus pathogenicity is discussed, with an emphasis on the role of HA0 cleavage as a determining factor...
- Occurrence of respiratory virus: time, place and personArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
Pediatr Infect Dis J 23:S58-64. 2004....
- Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virusKelly K Lee
Department of Medicinal Chemistry and Biomolecular Structure and Design Program, University ofWashington, Seattle, Washington 98195, USA
J Biol Chem 286:42141-9. 2011..These results provide proof of concept for an antiviral strategy that is applicable to intracellularly fusing viruses, including known and emerging viral pathogens...
- Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infectionVilma Decman
Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
J Immunol 184:5151-9. 2010..Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity...
- The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the OrthomyxoviridaeB Krossøy
Department of Fisheries and Marine Biology, University of Bergen, Bergen, Norway
J Virol 73:2136-42. 1999..regions of other segmented negative-stranded RNA viruses shows a closer relationship with members of the Orthomyxoviridae than with viruses in other families...
- Evaluation of an influenza-like illness case definition in the diagnosis of influenza among patients with acute febrile illness in CambodiaMatthew R Kasper
U S Naval Medical Research Unit 2, Jakarta, Indonesia
BMC Infect Dis 10:320. 2010..0°C) with cough or sore throat. In this study, we tested the sensitivity, specificity, and positive and negative predictive values of this case definition in a Cambodia patient population...
- Airborne influenza virus detection with four aerosol samplers using molecular and infectivity assays: considerations for a new infectious virus aerosol samplerP Fabian
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Indoor Air 19:433-41. 2009..As a first step in designing a new air sampler to collect influenza virus we evaluated four commercial samplers and determined necessary design parameters for a new collector...
- Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion proteinGallen B Triana-Baltzer
NexBio Inc, San Diego, CA, USA
PLoS ONE 4:e7838. 2009..DAS181 inhibits IFV that is resistant to NAIs. Thus, DAS181 may offer an alternative therapeutic option for seasonal or pandemic IFVs that become resistant to currently available antiviral drugs...
- Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virusChen Chen
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:11790-5. 2008..These results suggest that epsin 1 functions as a cargo-specific adaptor for the clathrin-mediated entry of the influenza virus...
- Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virusC R Baskin
Department of Comparative Medicine, University of Washington, Seattle, Washington 981951, USA
J Virol 81:11817-27. 2007..This protection was achieved in the absence of significant or long-lasting adverse effects and through induction of a robust adaptive immune response...
- Towards an atomic resolution understanding of the influenza virus replication machineryRob W H Ruigrok
Unit of Virus Host Cell Interactions, UJF EMBL CNRS, UMI 3265, Grenoble, France
Curr Opin Struct Biol 20:104-13. 2010..These results provide the first detailed structure-function insights into polymerase assembly, transcription and host adaptation and will have an impact on anti-influenza drug design...
- Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in childrenT G Boyce
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Vaccine 18:82-8. 1999..015). Two doses of CAIV-T induce a mucosal IgA response to all three influenza vaccine antigens in the majority of children. In addition, a mucosal antibody response may be the only indication of a vaccine take in a seropositive child...
- Antiviral instruction of bone marrow leukocytes during respiratory viral infectionsTamar Hermesh
Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Cell Host Microbe 7:343-53. 2010..These findings show that appropriate instruction of cells during their development in the bone marrow is needed for effective control of infection...
- Respiratory viruses detected in hospitalised paediatric patients with respiratory infectionsS Zamberi
Department of Clinical Laboratory Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor
Med J Malaysia 58:681-7. 2003..4%) and croup (27%). Viral aetiologies were confirmed in 23.4% of the patients. The most common respiratory virus isolated or detected was RSV, followed by parainfluenza viruses, influenza viruses and adenovirus...
- Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: implications for disparate immune system priming pathwaysWilliam A Langley
Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
J Virol 84:8300-7. 2010..In some cases, such toxin-neutralizing activity was notably high, indicating that the mechanisms by which immunity is primed by live influenza virus vectors may have beneficial properties...
- Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomesMelike Lakadamyali
Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
Cell 124:997-1009. 2006..This pre-early endosome sorting process begins at clathrin-coated vesicles, depends on microtubule-dependent motility, and appears to involve endocytic adaptors...
- Influenza virus NS vectors expressing the mycobacterium tuberculosis ESAT-6 protein induce CD4+ Th1 immune response and protect animals against tuberculosis challengeSabine Sereinig
Institute of Applied Microbiology, Muthgasse 18, 1190 Vienna, Austria
Clin Vaccine Immunol 13:898-904. 2006..tuberculosis-specific Th1 immune response in mice. Moreover, intranasal immunization of mice and guinea pigs with such vectors induced protection against mycobacterial challenge, similar to that induced by BCG vaccination...
- Minimum molecular architectures for transcription and replication of the influenza virusAyae Honda
Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
Proc Natl Acad Sci U S A 99:13166-71. 2002..Taken together we propose that the catalytic specificity of PB1 subunit is modulated to the transcriptase by binding PB2 or the replicase by interaction with PA...
- Predicting influenza infections during epidemics with use of a clinical case definitionG Boivin
Research Center in Infectious Diseases and Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
Clin Infect Dis 31:1166-9. 2000..8%, 39.3%, 77.6%, and 55.0%, respectively...
- Patterns of influenza-associated mortality among US elderly by geographic region and virus subtype, 1968-1998Sharon K Greene
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Am J Epidemiol 163:316-26. 2006..23, standard deviation = 0.058). These novel analyses suggest that causes of spatial heterogeneity (e.g., large-scale environmental drivers and population movement) have impacted influenza-associated mortality...
- Host factor Ebp1: selective inhibitor of influenza virus transcriptaseAyae Honda
Department of Frontier Bioscience and Micro Nano Technology Research Center, Hosei University, Koganei, Tokyo 184 8584, Japan
Genes Cells 12:133-42. 2007....
- Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their useArnold S Monto
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Antimicrob Agents Chemother 50:2395-402. 2006..The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use...
- Visualizing infection of individual influenza virusesMelike Lakadamyali
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 100:9280-5. 2003..This finding suggests a previously undescribed scenario of the endocytic pathway toward late endosomes: endosome maturation, including initial acidification, largely occurs in the perinuclear region...
- Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protectionFilippo Ansaldi
Department of Health Sciences, University of Genoa CIRI IV, Inter University Research Centre on Influenza, Via Pastore 1, 16132 Genoa, Italy
Vaccine 27:3345-8. 2009..Promising results were obtained using a new generation of oil-in-water emulsion adjuvants, named AS, offering cross-protection against heterologous challenge in ferrets...
- Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposureAlexandre Harari
Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
J Virol 83:2862-71. 2009..These results advance our understanding of the relationship between distinct profiles of cytotoxic granules in memory CD8 T cells and function, differentiation stage, and antigen exposure...
- Altered peptidase and viral-specific T cell response in LMP2 mutant miceL van Kaer
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
Immunity 1:533-41. 1994..These findings indicate that LMP2 influences antigen processing...
- Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lungGodelieve J de Bree
Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
J Infect Dis 195:1718-25. 2007..We investigated CD4(+) memory T cell responses to influenza virus (FLU), respiratory syncytial virus (RSV), and nontypeable Haemophilus influenzae (NTHi)...
- Role of host protein Ebp1 in influenza virus growth: intracellular localization of Ebp1 in virus-infected and uninfected cellsAyae Honda
Department of Frontier Bioscience and Micro Nano Technology Research Center, Hosei University, Koganei, Tokyo, Japan
J Biotechnol 133:208-12. 2008..Ebp1 was found to localize in the nuclear membrane of uninfected cells, and to form nuclear aggregates with viral P proteins in virus-infected cells...
- Antigen-based assays for the identification of influenza virus and respiratory syncytial virus: why and how to use them in pediatric practiceNicola Principi
Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milano, Italy
Clin Lab Med 29:649-60. 2009..The most recently marketed tests are similarly effective in identifying viruses, and so pediatricians should choose those that are less expensive, less time consuming, and easier to perform and to interpret...
- A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme BCatherine Ewen
Department of Biochemistry, University of Alberta, 463 Medical Sciences Bldg, T6G 2H7, Edmonton, Alberta, Canada
J Immunol Methods 276:89-101. 2003..The novel cytotoxic assay presented here should give investigators a sensitive, cross-species, nonradioactive alternative to 51Cr-release assays as a means to assess antigen-specific CTL responses in vaccine trials...
- Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanismsK Ghoshal
Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, 333 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
Mol Cell Biol 21:8301-17. 2001..These results have demonstrated that MT-I and MT-II can be induced robustly in the liver and lung following experimental influenza virus infection by overlapping but distinct molecular mechanisms...
- Working towards a simple case definition for influenza surveillanceKarin Thursky
Victorian Infectious Diseases Reference Laboratory, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia
J Clin Virol 27:170-9. 2003..A single definition of influenza-like illness (ILI) has been recommended by the Australian Influenza Pandemic planning committee for influenza surveillance systems throughout Australia...
- Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cellsM V Dhodapkar
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
J Exp Med 193:233-8. 2001..These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity...
- Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal miceMehran Haidari
University of Texas Health Science Center at Houston, Houston, TX, USA
Atherosclerosis 208:90-6. 2010..We assessed the vascular effects of influenza infection and whether the virus can directly infect atherosclerotic arteries in mice...
- Influenza vaccines: present and futurePeter Palese
Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
J Clin Invest 110:9-13. 2002
- Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunitFranck Tarendeau
European Molecular Biology Laboratory EMBL Grenoble Outstation, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
Nat Struct Mol Biol 14:229-33. 2007..The domain contains three surface residues implicated in adaptation from avian to mammalian hosts. One of these tethers the NLS-containing peptide to the core of the domain in the unbound state...
- Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenzaJavier Rangel-Moreno
The Trudeau Institute, Saranac Lake, NY 12983, USA
Proc Natl Acad Sci U S A 104:10577-82. 2007..These results demonstrate that the local expression of homeostatic chemokines in nonlymphoid organs, such as the lung, plays an important role in protective immune responses...
- Role of apoptosis and cytokines in influenza virus morbidityEdward W A Brydon
Department of Microbiology, New York, NY 100029 6574, USA
FEMS Microbiol Rev 29:837-50. 2005....
- CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punchDeborah M Brown
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 177:2888-98. 2006....
- The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replicationAgustín Portela
División de Productos Biológicos y Biotecnología, Agencia Española del Medicamento, Majadahonda 28220, Madrid, Spain
J Gen Virol 83:723-34. 2002..The evidence for the existence of each of these activities and their possible roles in transcription, replication and intracellular trafficking of the virus genome is considered...
- Estimation of influenza vaccine effectiveness from routine surveillance dataHeath Kelly
Epidemiology Unit and Virus Identification Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia
PLoS ONE 4:e5079. 2009..It is possible to use a case control method to estimate vaccine effectiveness from surveillance data when all patients in a surveillance system are tested for influenza and their vaccination status is known...
- The influenza A virus nucleoprotein: structure and functionYizhi Jane Tao; Fiscal Year: 2012..B virus and determine whether NP self-oligomerization and RNA binding modes are broadly conserved in the Orthomyxoviridae family. 2. Elucidate the role of NP in viral RNA replication...
- 6th Orthomyxovirus Research ConferenceSTACEY L SCHULTZ-CHERRY; Fiscal Year: 2012..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- Pathogenic determinants of an emerging infectious diseaseJames K Jancovich; Fiscal Year: 2012....
- Retrocyclin reinforcement of pulmonary defenses against viral aerosolsRobert Lehrer; Fiscal Year: 2007..1. To test retrocyclins against potential viral bioterrorism agents, including Influenza A and B (Orthomyxoviridae), HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia ..
- INFLUENZA B VIRUS AND MATRIX GENE ORFDAN DEBORDE; Fiscal Year: 1990Influenza A and B viruses are both members of the genus Influenzavirus of the Family Orthomyxoviridae, and as such are closely related in genome, structure, and pathogenicity...
- Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample preparDarrell Chandler; Fiscal Year: 2007..Influenza viruses are highly contagious, segmented negative-sense RNA viruses that belong to the family Orthomyxoviridae, causing approximately 114,000 hospitalizations and 20,000 deaths annually...
- GLYCOCONJUGATES IN VIRAL PATHOGENESISGILLIAN AIR; Fiscal Year: 2007..abstract_text> ..
- Investigation of influenza virulence mediated by the NS1A proteinDIANA NOAH; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Influenza viruses (Orthomyxoviridae family) cause a highly contagious respiratory disease in humans resulting in approximately 36,000 deaths in the United States annually...
- 4th Orthomyxovirus Research ConferenceStacey Schultz Cherry; Fiscal Year: 2007..The purpose[unreadable] of this proposal is to provide funds that will allow promising young investigators to[unreadable] interact with their peers and develop a commitment to this area of research. ..
- INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSESDEBI NAYAK; Fiscal Year: 1993..These experiments would enable us to define the function of individual P proteins and the locatio of critical domain(s) and site(s) in the RNA and proteins involved in transcription and replication...
- Synergism Between Influenza Virus and PneumococcusJonathan McCullers; Fiscal Year: 2009....
- Influenza-pneumococcal synergism: role of neuraminidaseJonathan McCullers; Fiscal Year: 2004....
- 2nd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2003..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- 3rd Orthomyxoviruses Research ConferenceJonathan McCullers; Fiscal Year: 2005..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
- Lethal synergism between influenza and pneumococcusJonathan McCullers; Fiscal Year: 2003....
- Novel broad spectrum vaccination against influenzaPetr Ilyinskii; Fiscal Year: 2006..The overall aim of this project is to demonstrate better protective effect or/and enhanced immune response using modified influenza proteins as immunogens compared to wild-type viral proteins. ..
- Modification of Conserved Influenza Genes Enabling their Elevated ExpressionPetr Ilyinskii; Fiscal Year: 2008..Therefore, if proven, our approach will lead to a novel paradigm for recombinant gene modifications for enhanced expression in vivo, both for vaccine and non-vaccine applications. [unreadable] [unreadable] [unreadable]..
- Memory T cell subsets and pulmonary immunityDavid L Woodland; Fiscal Year: 2010....
- Alphavirus-based Vaccine for Prevention of MPV InfectionJames Crowe; Fiscal Year: 2008..The consortium submitting this application brings together an experienced investigator group with expertise in pneumovirus and alphavirus virology, immunology, and vaccine development. ..
- Therapeutics to Prevent/Treat Lassa Fever VirusMichael B Oldstone; Fiscal Year: 2010..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
- INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSESDEBI NAYAK; Fiscal Year: 2007..abstract_text> ..
- The Role of the RET Receptor in Autoimmune DiseaseLaurence Eisenlohr; Fiscal Year: 2007..By deciphering the role of RETECD antibody in disease, we can design improved methods and drugs for the abrogation of thyroid and other organ-specific autoimmune disorders. [unreadable] [unreadable] [unreadable]..
- Mechanisms of influenza NA drug resistanceJennifer L McKimm Breschkin; Fiscal Year: 2010....
- RESPIRATORY VIRUS ION CHANNELSLAWRENCE PINTO; Fiscal Year: 2007..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
- Advances in Influenza Research - From Birds to Bench to BedsideDAVID WOODLAND; Fiscal Year: 2006..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
- The Basis for MHC Class II-restricted proteasome-dependent epitopesLAURENCE CRANE EISENLOHR; Fiscal Year: 2010..Execution of the plan could fundamentally alter the general perception of CD4+ T cell responses and the roles they play in protection, thereby strongly influencing the design of future vaccines. ..
- Arenavirus Receptor-Structure/Function StudiesMichael B Oldstone; Fiscal Year: 2010..These findings have relevance for biodefense of several viruses including LFV. ..
- The impact of the pneumococcal conjugate vaccine on pneumonia hospitalizationsCARLOS GRIJALVA; Fiscal Year: 2008..We propose the use of NIS and SID for the evaluation of the pneumococcal conjugate vaccination program, using an innovative approach. [unreadable] [unreadable] [unreadable] [unreadable]..
- Aging Disease--Prion/Transgenic/Immunologic StudiesMichael Oldstone; Fiscal Year: 2008..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
- Class II Processing Delineated by Flu GlycoproteinsLaurence Eisenlohr; Fiscal Year: 2008..abstract_text> ..
- Reducing Transmission of Influenza by Face MasksARNOLD MONTO; Fiscal Year: 2008..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
- Dissecting 3 processing pathways that generate class II-restricted flu epitopesLaurence Eisenlohr; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Respiratory Syncytial Virus Nanoparticle VaccinesJames Crowe; Fiscal Year: 2008..The development of a new technology for vaccination using nanoparticles also could have wide impact, since such a vaccine technology might be useful in developing vaccines against other infections. [unreadable] [unreadable] [unreadable]..
- Studies on Influenza B Virus BM2 Protein Ion ChannelLAWRENCE PINTO; Fiscal Year: 2009....
- Early Regulation of Immunity in the Respiratory TractNicole Baumgarth; Fiscal Year: 2007..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
- Nutrition, Viral Mutation and Host DefenseMelinda Beck; Fiscal Year: 2007..abstract_text> ..
- Regulation of CD8+ T cell responses to influenza virusDAVID WOODLAND; Fiscal Year: 2007..abstract_text> ..
- Viruses and DiabetesMichael Oldstone; Fiscal Year: 2005....
- ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANSJames Crowe; Fiscal Year: 2001..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
- STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASEMichael Oldstone; Fiscal Year: 2001..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
- CD4+T cell immunity to respiratory virus infectionsDAVID WOODLAND; Fiscal Year: 2004....
- T CELL RECOGNITION OF BACTERIAL SUPERANTIGENSDAVID WOODLAND; Fiscal Year: 2002..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
- High Throughput Flow Cytometry SorterJames Crowe; Fiscal Year: 2004..The requested instrument will meet all of these demonstrated needs. ..
- TRANSFECTANT INFLUENZA VIRUSES IN CANCER THERAPYAdolfo Garcia Sastre; Fiscal Year: 2002..The proposed research may advance the field of cancer therapy towards possible novel ways to treat human tumors and prolong survival of cancer patients. ..
- Pathogenesis Studies in Scrapie (TSE Diseases)Michael Oldstone; Fiscal Year: 2003..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
- IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORYLaurence Eisenlohr; Fiscal Year: 2003..He believes that the pursuit of these aims will provide fundamentally important information about TCD8+-mediated immunity and will put us in a strong position to address the next generation of questions that will be facing the field. ..
- HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIAJames Crowe; Fiscal Year: 2002..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..
- Human T Cells Responses to RSVJames Crowe; Fiscal Year: 2006..abstract_text> ..
- High Throughput Assays for Ion Channel Activities of Influenza A & B VirusesLAWRENCE PINTO; Fiscal Year: 2006..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
- VIRUSES AND AUTOIMMUNE DISEASEMichael Oldstone; Fiscal Year: 2001..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
- The Role of Nutrition in Virus-Induced Optic NeuropathyMelinda Beck; Fiscal Year: 2006..unreadable] [unreadable]..
- INFLUENZA VIRUS RIBONUCLEOPROTEINS (RNP)Peter Palese; Fiscal Year: 2006..abstract_text> ..
- CELL MEDIATED IMMUNITY TO SENDAI VIRUSDAVID WOODLAND; Fiscal Year: 2001....
- MEASLES VIRUS STUDIES IN A TRANSGENIC MODELMichael Oldstone; Fiscal Year: 2007..abstract_text> ..
- Comparative Study of Influenza Vaccines in AdultsARNOLD MONTO; Fiscal Year: 2006..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
- Virulence factors of influenza virus: The NS1 proteinAdolfo Garcia Sastre; Fiscal Year: 2010..abstract_text> ..
- Novel methods for generation of human B cell hybridomasJames Crowe; Fiscal Year: 2005..abstract_text> ..
- Human Antibody Responses to RotavirusJames Crowe; Fiscal Year: 2007..unreadable] [unreadable]..
- Cell-Mediated Immune Responses to Vaccinia VirusesJames Crowe; Fiscal Year: 2006..We will examine many of these questions by taking advantage of new technology that allows for examination of T cell responses at the single cell level, and in an immunodominant epitope specific manner. [unreadable] [unreadable]..
- Immunomodulation on the Nanoscale (RMI)James Crowe; Fiscal Year: 2004..Immunology and infectious diseases. 2. Materials science, especially nanoparticles, nanowires, and nanofluidics. 3. Instrumented platforms for cellular imaging and control. 4. Biocomputing. ..
- The Influence of Nutrition on Influenza Virus InfectionMelinda Beck; Fiscal Year: 2004..abstract_text> ..
- CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTSDEBI NAYAK; Fiscal Year: 2005..A detailed understanding of these processes will facilitate the rational development of antiviral agents which could interfere with one or more steps in virus assembly. ..
- Development of Guinea Pig as Mamalian for Influenza Virus TransmissionPeter Palese; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Rapid Vaccine Development SystemGary Fujii; Fiscal Year: 2002..Evaluation of the anthrax antigen liposomes in preclinical animal models will be conducted in the Phase II studies. ..
- Non-Viral Pandemic Influenza Vaccine DevelopmentGary Fujii; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Development of an Aspergillus VaccineGary Fujii; Fiscal Year: 2008..Thus, a safe and effective vaccine against A. fumigatus would save health care dollars (and have significant dollar value) and, most importantly, save lives. [unreadable] [unreadable] [unreadable]..
- Liposomal Adjuvant for Vaccine DevelopmentGary Fujii; Fiscal Year: 2008..Moreover, liposomal formulations might also be discovered that could be developed into the next generation anthrax vaccine. [unreadable] [unreadable] [unreadable]..
- Genital Herpes Vaccine DiscoveryGary Fujii; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Alteration of Human Dendritic Cell Subsets by RSVMichelle Gill; Fiscal Year: 2008..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..