coronaviridae

Summary

Summary: Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.

Top Publications

  1. ncbi Virus-encoded proteinases and proteolytic processing in the Nidovirales
    J Ziebuhr
    Institute of Virology and Immunology, University of Wurzburg, Versbacher Str 7, 97078 Wurzburg, Germany
    J Gen Virol 81:853-79. 2000
  2. pmc Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential
    Eveline Kindler
    Institute of Immunobiology, Kantonal Hospital, St Gallen, Switzerland
    MBio 4:e00611-12. 2013
  3. ncbi Molecular diversity of coronaviruses in bats
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Virology 351:180-7. 2006
  4. ncbi Molecular interactions in the assembly of coronaviruses
    Cornelis A M de Haan
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    Adv Virus Res 64:165-230. 2005
  5. pmc Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae
    Barry R O'Keefe
    Molecular Targets Development Program, Center for Cancer Research, NCI Frederick, Frederick, Maryland 217021, USA
    J Virol 84:2511-21. 2010
  6. pmc Detection of alpha and betacoronaviruses in multiple Iberian bat species
    Ana Falcón
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Arch Virol 156:1883-90. 2011
  7. pmc Evolutionary insights into the ecology of coronaviruses
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Li Ka Shing Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    J Virol 81:4012-20. 2007
  8. pmc Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 81:1574-85. 2007
  9. ncbi Autophagy-independent LC3 function in vesicular traffic
    Cornelis A M de Haan
    Virology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Autophagy 6:994-6. 2010
  10. ncbi A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae
    J M Gonzalez
    Centro Nacional de Biotecnologia, CSIC, Department of Molecular and Cell Biology, Campus Universidad Autonoma, Cantoblanco, Madrid, Spain
    Arch Virol 148:2207-35. 2003

Scientific Experts

Detail Information

Publications181 found, 100 shown here

  1. ncbi Virus-encoded proteinases and proteolytic processing in the Nidovirales
    J Ziebuhr
    Institute of Virology and Immunology, University of Wurzburg, Versbacher Str 7, 97078 Wurzburg, Germany
    J Gen Virol 81:853-79. 2000
  2. pmc Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential
    Eveline Kindler
    Institute of Immunobiology, Kantonal Hospital, St Gallen, Switzerland
    MBio 4:e00611-12. 2013
    ..Importantly, type I and type III interferon treatment can efficiently reduce HCoV-EMC replication in the human airway epithelium, providing a possible avenue for treatment of emerging virus infections...
  3. ncbi Molecular diversity of coronaviruses in bats
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Virology 351:180-7. 2006
    ..An astonishing diversity of coronaviruses was observed in bats...
  4. ncbi Molecular interactions in the assembly of coronaviruses
    Cornelis A M de Haan
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    Adv Virus Res 64:165-230. 2005
  5. pmc Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae
    Barry R O'Keefe
    Molecular Targets Development Program, Center for Cancer Research, NCI Frederick, Frederick, Maryland 217021, USA
    J Virol 84:2511-21. 2010
    Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens...
  6. pmc Detection of alpha and betacoronaviruses in multiple Iberian bat species
    Ana Falcón
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Arch Virol 156:1883-90. 2011
    ..Interestingly, although some of these viruses are related to other European BatCoV, or to Asian CoV, some of the viruses found in Spain cluster in new groups of α and β CoV...
  7. pmc Evolutionary insights into the ecology of coronaviruses
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Li Ka Shing Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    J Virol 81:4012-20. 2007
    Although many novel members of the Coronaviridae have recently been recognized in different species, the ecology of coronaviruses has not been established...
  8. pmc Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 81:1574-85. 2007
    ..Further molecular epidemiological studies on coronaviruses in the bats of other countries, as well as in other animals, and complete genome sequencing will shed more light on coronavirus diversity and their evolutionary histories...
  9. ncbi Autophagy-independent LC3 function in vesicular traffic
    Cornelis A M de Haan
    Virology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands
    Autophagy 6:994-6. 2010
    ..While it seems clear that CoVs hijack ER-derived host cell membranes for replication, the mechanism by which these DMVs are assembled has remained completely mysterious...
  10. ncbi A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae
    J M Gonzalez
    Centro Nacional de Biotecnologia, CSIC, Department of Molecular and Cell Biology, Campus Universidad Autonoma, Cantoblanco, Madrid, Spain
    Arch Virol 148:2207-35. 2003
    The Coronaviridae family, comprising the Coronavirus and Torovirus genera, is part of the Nidovirales order that also includes two other families, Arteriviridae and Roniviridae...
  11. ncbi Coronavirus MHV-JHM mRNA 5 has a sequence arrangement which potentially allows translation of a second, downstream open reading frame
    M A Skinner
    J Gen Virol 66:581-92. 1985
    ..Preliminary evidence is presented showing that the downstream open reading frame is functional in vivo...
  12. ncbi Differential detection of transmissible gastroenteritis virus and porcine epidemic diarrhea virus by duplex RT-PCR
    S Y Kim
    Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea
    J Vet Diagn Invest 13:516-20. 2001
    ..This duplex RT-PCR may be a useful diagnostic method for the rapid, specific, and sensitive differential detection of TGE and PED viruses using clinical samples...
  13. ncbi Sequences of the nucleocapsid genes from two strains of avian infectious bronchitis virus
    M E Boursnell
    J Gen Virol 66:573-80. 1985
    ..The major difference between the sequences determined for the two IBV strains is that the 3' non-coding region of the Beaudette strain contains a 184 base segment which is not present in the M41 strain...
  14. ncbi Sequence of the membrane protein gene from avian coronavirus IBV
    M E Boursnell
    Virus Res 1:303-13. 1984
    ..This is in agreement with the molecular weight of 23 000 reported for the unglycosylated form of the membrane polypeptide...
  15. ncbi Use of an internal control in a quantitative RT-PCR assay for quantitation of porcine epidemic diarrhea virus shedding in pigs
    Dae Sub Song
    Research Unit, Green Cross Veterinary Products, Yong in 449 903, Korea
    J Virol Methods 133:27-33. 2006
    Porcine epidemic diarrhea virus (PEDV), a member of the family Coronaviridae, has caused a devastating enteric disease in the Korean swine industry...
  16. ncbi Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus
    K Jung
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56 1, Kwanak gu, 151 742 Seoul, Republic of Korea
    Res Vet Sci 81:310-5. 2006
    ..Reduced enzymatic activity and villous atrophy in the small intestine is thought to result in a maldigestive and malabsorptive diarrhea...
  17. ncbi Clinicopathologic features of a systemic coronavirus-associated disease resembling feline infectious peritonitis in the domestic ferret (Mustela putorius)
    M M Garner
    Northwest ZooPath, 654 W Main, Monroe, WA 98296, USA
    Vet Pathol 45:236-46. 2008
    ..Partial sequencing of the coronavirus spike gene obtained from frozen tissue indicates that the virus is related to ferret enteric coronavirus...
  18. ncbi Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus
    A Bridgen
    Institut fur Virologie, Veterinärmedizinische Fakultät, Universitat Zurich, Switzerland
    J Gen Virol 74:1795-804. 1993
    ..Several RNA motifs typical of coronaviruses were also observed. These results confirm the earlier provisional classification of PEDV as a coronavirus...
  19. ncbi Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong
    Virology 367:428-39. 2007
    ..These suggest a common evolutionary origin in the spike protein of bat-CoV HKU2, bat-SARS-CoV, and SARS-CoV...
  20. ncbi SYBR Green real-time reverse transcription-polymerase chain reaction assay for the generic detection of coronaviruses
    S Escutenaire
    Department of Virology, National Veterinary Institute, Uppsala, Sweden
    Arch Virol 152:41-58. 2007
    ..The developed assay represents a potential tool for laboratory diagnostics and for detecting still uncharacterized coronaviruses...
  21. ncbi Detection of the new human coronavirus HKU1: a report of 6 cases
    Astrid Vabret
    Laboratory of Virology, University Hospital of Caen, Caen, France
    Clin Infect Dis 42:634-9. 2006
    ..To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients...
  22. ncbi Coding sequence of coronavirus MHV-JHM mRNA 4
    M A Skinner
    J Gen Virol 66:593-6. 1985
    ..An intracellular, virus-specific polypeptide, which has been previously described having a mol. wt. of 14 000 to 14 500 has the size and charge characteristics of such a translation product...
  23. pmc An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV
    I Brierley
    Department of Pathology, University of Cambridge, UK
    EMBO J 6:3779-85. 1987
    ..The nature of the products was confirmed by their reactivity with antisera raised against defined portions of the flanking marker gene. This is the first non-retroviral example of ribosomal frame-shifting in higher eukaryotes...
  24. ncbi Isotype-specific antibody-secreting cells in systemic and mucosal associated lymphoid tissues and antibody responses in serum of conventional pigs inoculated with PEDV
    M L de Arriba
    Departamento de Sanidad Animal Enfermedades Infecciosas y Epidemiología, Facultad de Veterinaria, Universidad de Leon, E 24071, Leon, Spain
    Vet Immunol Immunopathol 84:1-16. 2002
    ....
  25. ncbi Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice
    S Kyuwa
    Department of Animal Pathology, University of Tokyo, Japan
    Microb Pathog 12:95-104. 1992
    ..These results may suggest that JHMV-induced late disease is also under multifactorial control. The pathogenesis of JHMV infection is discussed...
  26. ncbi Detection of White Spot Syndrome virus and Yellowhead virus in prawns imported into Australia
    K A McColl
    CSIRO Livestock Industries, Australian Animal Health Laboratory, PO Bag 24, Geelong, Victoria 3220
    Aust Vet J 82:69-74. 2004
    ..To determine whether viable White Spot Syndrome virus (WSSV) or Yellowhead virus (YHV) were present in prawn products imported into Australia...
  27. ncbi Commentary: McIntosh K, Chao RK, Krause HE, Wasil R, Mocega HE, Mufson MA. Coronavirus infection in acute lower respiratory tract disease of infants. J Infect Dis 1974; 130:502-7
    Kenneth McIntosh
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Massachusetts 02115, USA
    J Infect Dis 190:1033-41. 2004
  28. ncbi High-level expression of the neutralizing epitope of porcine epidemic diarrhea virus by a tobacco mosaic virus-based vector
    Tae Jin Kang
    Institute of Basic Science, Chonbuk National University, Jeonju 561 756, Republic of Korea
    Protein Expr Purif 38:129-35. 2004
    ..Therefore, this result indicates that the plant viral expression system with a synthetic gene optimized for plant expression is suitable to produce a large amount of antigen for the development of plant-based vaccine rapidly...
  29. ncbi The classification of viruses infecting the respiratory tract
    P L Mackie
    Department of Microbiology, Yorkhill NHS Trust, Glasgow, G3 8SJ, UK
    Paediatr Respir Rev 4:84-90. 2003
    ..However, this varied and diverse group can be divided among six distinct families. Understanding some of the basic biology of these families gives an insight into possible strategies for diagnosis, control and therapy...
  30. ncbi Enteric coronavirus TGEV: partial sequence of the genomic RNA, its organization and expression
    D Rasschaert
    Institut National de la Recherche Agronomique, Station de Recherches de Virologie et d Immunologie, Thiverval Grignon, France
    Biochimie 69:591-600. 1987
    ..RNA species detected in TGEV-infected cells form a 3'-coterminal 'nested' structure, a unique feature of Coronaviridae. The transcription initiation site of the TGEV subgenomic RNAs appears to involve the hexameric sequence 5'..
  31. ncbi Neutralizing test of hemagglutinating encephalomyelitis virus (HEV) in FS-L3 cells cultured without serum
    Ikuko Sasaki
    Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Vet Med Sci 65:381-3. 2003
    ..Our results support the idea that the VN is a more reliable measure of HEV infection than the conventionally used HI test...
  32. ncbi The propagation of a porcine epidemic diarrhea virus in swine cell lines
    K Kadoi
    Laboratory of Bio medical Science, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
    New Microbiol 25:285-90. 2002
    ..Small but clear plaques were formed under an agar overlay medium on the cells. The infective titer in the order of 10(7.00-7.50) TCID50 per ml was obtained at usual incubation temperature...
  33. ncbi How the SARS vaccine effort can learn from HIV-speeding towards the future, learning from the past
    Anne S De Groot
    TB HIV Research Laboratory, Brown University, Providence, RI 02912, USA
    Vaccine 21:4095-104. 2003
    ..This article reviews parallels between HIV and SARS and proposes an approach that would accelerate the development of a SARS vaccine...
  34. ncbi A review of viral gastroenteritis
    Benjamin Clark
    Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Curr Opin Infect Dis 17:461-9. 2004
    ..Although bacteria and other pathogens cause significant numbers of gastroenteritis, it is the viruses that are dealt with in this review. The viruses responsible will be discussed individually...
  35. pmc Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily
    J A den Boon
    Department of Virology, Faculty of Medicine, Leiden University, The Netherlands
    J Virol 65:2910-20. 1991
    ..The EAV ORF1a product contains a putative trypsinlike serine protease motif. Our data indicate that EAV, presently considered a togavirus, is evolutionarily related to viruses from the coronaviruslike superfamily...
  36. ncbi Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus
    M E Boursnell
    J Gen Virol 68:57-77. 1987
    ..Because of this, and because of the characteristics of the sequence in the region immediately upstream of its start codon, other mechanisms of translation, such as ribosome slippage, must be postulated...
  37. pmc Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2
    Amornrat Kanjanahaluethai
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Virol 77:7376-82. 2003
    ..This study is the first report of the identification and characterization of a cleavage site recognized by murine coronavirus PLP2 activity...
  38. ncbi Cloning and sequencing of the gene encoding the spike protein of the coronavirus IBV
    M M Binns
    J Gen Virol 66:719-26. 1985
    ..The amino acid analysis also reveals the presence of an 18 amino acid putative signal sequence on the primary translation product which is not present on the mature S1 polypeptide...
  39. ncbi A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-derived zinc-chelating trioxa-adamantane-triol
    Andreas J Kesel
    Chammünsterstr 47, D 81827 München, Germany
    Bioorg Med Chem 11:4599-613. 2003
    ..Louis encephalitis virus, hepatitis C virus), Togaviridae (rubella virus), Coronaviridae (human coronavirus, human SARS-associated coronavirus), Rhabdoviridae (rabies virus), Paramyxoviridae (human ..
  40. pmc The fecal viral flora of wild rodents
    Tung G Phan
    Blood Systems Research Institute, San Francisco, California, United States of America
    PLoS Pathog 7:e1002218. 2011
    ..Picobirnaviridae, Picornaviridae, Astroviridae, Parvoviridae, Papillomaviridae, Adenoviridae, and Coronaviridae. Seventeen small circular DNA genomes containing one or two replicase genes distantly related to the ..
  41. ncbi Coronavirus genome structure and replication
    D A Brian
    Departments of Microbiology and Pathobiology, University of Tennessee, College of Veterinary Medicine, Knoxville, TN 37996 0845, USA
    Curr Top Microbiol Immunol 287:1-30. 2005
    ..genome is shared with other members of the Nidovirus order (the torovirus genus, also in the family Coronaviridae, and members of the family Arteriviridae) in that the nonstructural proteins involved in proteolytic ..
  42. pmc The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
    Helene Malet
    Architecture et Fonction des Macromolecules Biologiques, CNRS and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, 13288 Marseille, France
    J Virol 83:6534-45. 2009
    ..X domains") constitute a protein module family present in all kingdoms of life, including viruses of the Coronaviridae and Togaviridae families...
  43. ncbi Naturally occurring parvoviral infection in Hungarian broiler flocks
    Elena Alina Palade
    Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science, Szent Istvan University, Budapest, Istvan utca 2, Hungary
    Avian Pathol 40:191-7. 2011
    ..from numerous families have been identified in the intestinal tracts of poultry with ED, such as Astroviridae, Coronaviridae, Reoviridae, Rotaviridae, and Parvoviridae...
  44. pmc Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses
    Linlin Li
    Blood Systems Research Institute 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 84:6955-65. 2010
    ..of the viral families Parvoviridae, Circoviridae, Picornaviridae, Adenoviridae, Poxviridae, Astroviridae, and Coronaviridae. No close relative of known human viral pathogens was identified in these bat populations...
  45. pmc Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3
    Benjamin W Neuman
    Molecular and Integrative Neurosciences Department, Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 82:5279-94. 2008
    ..Based on new experimental data and a bioinformatics analysis across the Coronaviridae, we propose a higher-resolution functional domain architecture for nsp3 that determines the interaction ..
  46. ncbi The novel hemagglutinin-esterase genes of human torovirus and Breda virus
    L Duckmanton
    Department of Microbiology and Medical Genetics, The University of Toronto, Toronto, Canada
    Virus Res 64:137-49. 1999
    Human torovirus (HTV) and Breda virus (BRV), members of the genus torovirus in the family Coronaviridae, are established infectious agents of humans and cattle, respectively...
  47. pmc Phylogenetic and evolutionary relationships among torovirus field variants: evidence for multiple intertypic recombination events
    S L Smits
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Virol 77:9567-77. 2003
    Toroviruses (family Coronaviridae, order Nidovirales) are enveloped, positive-stranded RNA viruses that have been implicated in enteric disease in cattle and possibly in humans...
  48. pmc Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes
    Phan Thi Nga
    Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    PLoS Pathog 7:e1002215. 2011
    Nidoviruses with large genomes (26.3-31.7 kb; 'large nidoviruses'), including Coronaviridae and Roniviridae, are the most complex positive-sense single-stranded RNA (ssRNA+) viruses...
  49. ncbi Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein
    Yanhui Xu
    Laboratory of Structural Biology, Tsinghua University, Beijing 100084, People s Republic of China
    Acta Crystallogr D Biol Crystallogr 60:2377-9. 2004
    ..severe acute respiratory syndrome (SARS), is a positive-stranded RNA virus (SARS-CoV) belonging to the Coronaviridae family with a genome that differs substantially from those of other known coronaviruses...
  50. ncbi Comparative and functional genomics of closteroviruses
    Valerian V Dolja
    Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA
    Virus Res 117:38-51. 2006
    The largest extant RNA genomes are found in two diverse families of positive-strand RNA viruses, the animal Coronaviridae and the plant Closteroviridae...
  51. ncbi Genetic analysis of canine group 2 coronavirus in Korean dogs
    Dong Jun An
    National Veterinary Research and Quarantine Service, Anyang, Kyunggi Do, 430 824, Republic of Korea
    Vet Microbiol 141:46-52. 2010
    ..originating from Korean dogs tested positive for infection with canine respiratory coronavirus (CRCoV) of Coronaviridae group 2...
  52. pmc Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging
    Chung Ke Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    J Virol 83:2255-64. 2009
    ..sequence homology, the physicochemical features described above may be conserved across different groups of Coronaviridae. The current results underscore the important roles of multisite nucleic acid binding and intrinsic disorder ..
  53. ncbi Detection of group 2a coronaviruses with emphasis on bovine and wild ruminant strains. Virus isolation and detection of antibody, antigen, and nucleic acid
    Mustafa Hasoksuz
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA
    Methods Mol Biol 454:43-59. 2008
    Group 2a of the Coronaviridae family contains human and animal pathogens that include mouse hepatitis virus, rat coronavirus, human respiratory coronaviruses OC43 and the recently identified HKU1 strain, a newly recognized canine ..
  54. ncbi Identification of new human coronaviruses
    Krzysztof Pyrc
    University of Amsterdam, Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Expert Rev Anti Infect Ther 5:245-53. 2007
    ..of the respiratory viruses belong to the Paramyxoviridae, Orthomyxoviridae, Picornaviridae, Adenoviridae and Coronaviridae families...
  55. pmc Genetic and antigenic characterization of newly isolated bovine toroviruses from Japanese cattle
    Toshihiro Ito
    Kyoto Biken Laboratories, Inc, 24 16 Makishima, Uji City, Kyoto 611 0041, Japan
    J Clin Microbiol 48:1795-800. 2010
    Torovirus, a member of the Coronaviridae family, is a gastrointestinal infectious agent that has been identified in humans, cattle, pigs, and equines...
  56. pmc Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy
    Yossef Kliger
    Compugen Ltd, Tel Aviv, 69512, Israel
    BMC Microbiol 3:20. 2003
    ..Since it is a member of the Coronaviridae, its spike protein (S2) is believed to play a central role in viral entry by facilitating fusion between the ..
  57. pmc Rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by RT-PCR and electrospray ionization mass spectrometry
    Kuan Fu Chen
    Johns Hopkins University, Department of Medicine, Baltimore, MD 21205, USA
    J Virol Methods 173:60-6. 2011
    ..to detect respiratory syncytial virus, influenza A and B, parainfluenza types 1-4, adenoviridae types A-F, coronaviridae, human bocavirus, and human metapneumovirus...
  58. pmc Characterization of Bafinivirus main protease autoprocessing activities
    Rachel Ulferts
    Centre for Infection and Immunity, The Queen s University of Belfast, Belfast, United Kingdom
    J Virol 85:1348-59. 2011
    ..type species, White bream virus (WBV), of the newly established genus Bafinivirus (order Nidovirales, family Coronaviridae, subfamily Torovirinae)...
  59. ncbi Detection and characterization of bovine torovirus from the respiratory tract in Japanese cattle
    Toshihiro Ito
    Kyoto Biken Laboratories, Inc, 24 16 Makishima cho Uji shi, 611 0041 Kyoto, Japan
    Vet Microbiol 136:366-71. 2009
    Bovine torovirus (BToV), a member of the Coronaviridae family, is a causative agent of diarrhea in cattle, but it may also possess tropism for the respiratory tract...
  60. pmc Candidates in Astroviruses, Seadornaviruses, Cytorhabdoviruses and Coronaviruses for +1 frame overlapping genes accessed by leaky scanning
    Andrew E Firth
    Biosciences Institute, University College Cork, Cork, Ireland
    Virol J 7:17. 2010
    ..In this article we gather together a number of promising candidate new overlapping genes that may be of interest to the community...
  61. ncbi Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes
    Mark P Ariaans
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Virology 385:68-73. 2009
    Infectious Bronchitis Virus, a member of the Coronaviridae, is a respiratory pathogen in poultry. We found that in vitro stimulation with IBV resulted in ChIFN-gamma production in splenocytes of both infected birds and uninfected birds...
  62. ncbi [The reverse genetics systems for human and animal RNA viruses]
    Yao Wei Huang
    Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, China
    Sheng Wu Gong Cheng Xue Bao 20:311-8. 2004
    ..topics about the rescue of the typical viruses are discussed, including poliovirus with the de novo synthesis, Coronaviridae with the largest size of genome, Flaviviridae with the instable clones, HCV with the quasispecies nature, ..
  63. ncbi A pancoronavirus RT-PCR assay for detection of all known coronaviruses
    Leen Vijgen
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
    Methods Mol Biol 454:3-12. 2008
    ..SARS, and the previously unrecognized human coronaviruses HCoV-NL63 and HCoV-HKU1, indicate that the family Coronaviridae harbors more members than was previously assumed...
  64. ncbi Human aminopeptidase N is a receptor for human coronavirus 229E
    C L Yeager
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    Nature 357:420-2. 1992
    ....
  65. pmc Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth
    Benjamin W Neuman
    The Scripps Research Institute, Department of Neuropharmacology, Division of Virology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 78:5891-9. 2004
    ..unconjugated oligomers were tested to determine sequence-specific antiviral efficacy against a member of the Coronaviridae, Mouse hepatitis virus (MHV)...
  66. ncbi Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae
    I Mei Yu
    Department of Biological Sciences and the Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 281:17134-9. 2006
    ..This finding provides structural evidence of the evolutionary link between Coronaviridae and Arteriviridae, suggesting that the N proteins of both viruses have a common origin.
  67. ncbi [Molecular cloning of human respiratory tract mucin and studies of mucin gene expression in tracheobronchial epithelium of the rat]
    B Jany

    Pneumologie 47:479-87. 1993
    ..This could represent an important initial step in the pathogenesis of tracheobronchial hypersecretion...
  68. pmc A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial
    Julie E Martin
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC 2610, Bethesda, MD 20892 3017, USA
    Vaccine 26:6338-43. 2008
    The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003...
  69. ncbi Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected
    Sara Akerstrom
    Centre for Microbiological Preparedness, Swedish Institute for Infectious Disease Control, Nobels Väg 18, Solna, Sweden
    Virology 395:1-9. 2009
    ..Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) belongs to the family Coronaviridae, was first identified during 2002-2003. Mortality in SARS patients ranges from between 6 to 55%...
  70. ncbi Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses
    Chi Wai Yip
    The School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Infect Genet Evol 9:1185-96. 2009
    ..the recent discovery of SARS-like CoV (SLCoV) in bats and the proposal of bats as the natural reservior of the Coronaviridae family...
  71. pmc Reverse transcription polymerase chain reaction and electrospray ionization mass spectrometry for identifying acute viral upper respiratory tract infections
    Kuan Fu Chen
    Department of Emergency Medicine, Johns Hopkins University, Baltimore, MD 21204, USA
    Diagn Microbiol Infect Dis 69:179-86. 2011
    ..to detect respiratory syncytial virus, influenza A and B, parainfluenza types 1-4, Adenoviridae types A-F, Coronaviridae, human bocavirus, and human metapneumovirus was evaluated using both mock-ups and frozen archived NPA (N = 280)..
  72. ncbi Detection of viruses identified recently in children with acute wheezing
    Ju Young Chung
    Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Korea
    J Med Virol 79:1238-43. 2007
    ..In children with acute wheezing, rhinovirus, hRSV, and hBoV were most frequently detected. Further studies including healthy control subjects are needed to define the clinical significance of hBoV in acute wheezing...
  73. pmc Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide
    Ikenna G Madu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 83:7411-21. 2009
    ..We propose that proteolytic cleavage within S2 exposes a novel internal fusion peptide for SARS-CoV S, which may be conserved across the Coronaviridae.
  74. pmc Nature of the virus associated with endemic Balkan nephropathy
    Cristina Riquelme
    Centro Nacional de Biotecnologica, CSIC, Campus Universidad Autonoma, Cantoblanco, Madrid, Spain
    Emerg Infect Dis 8:869-70. 2002
  75. pmc Severe acute respiratory syndrome revisited
    Maria Zambon
    BMJ 326:831-2. 2003
  76. ncbi The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns"
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    J Formos Med Assoc 112:372-81. 2013
    ....
  77. pmc Recombination in avian gamma-coronavirus infectious bronchitis virus
    Sharmi W Thor
    Department of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Viruses 3:1777-99. 2011
    Recombination in the family Coronaviridae has been well documented and is thought to be a contributing factor in the emergence and evolution of different coronaviral genotypes as well as different species of coronavirus...
  78. ncbi Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection
    Kevin Maringer
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA School of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Cytokine Growth Factor Rev 25:669-79. 2014
    ..literature review to summarise the known mechanisms by which RNA viruses of the families Flaviviridae and Coronaviridae evade sensing through STING...
  79. pmc Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces
    Zhiqiang Wu
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    J Virol 86:10999-1012. 2012
    ..Herpesviridae, Papillomaviridae, Retroviridae, Circoviridae, Rhabdoviridae, Astroviridae, Flaviridae, Coronaviridae, Picornaviridae, and Parvovirinae; insect viruses included those of the Baculoviridae, Iflaviridae, ..
  80. ncbi A multiplex RT-PCR assay for rapid and differential diagnosis of four porcine diarrhea associated viruses in field samples from pig farms in East China from 2010 to 2012
    Jin Zhao
    Key Laboratory of Animal Diseases Diagnosis and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    J Virol Methods 194:107-12. 2013
    ..Taken together, all data indicated that this mRT-PCR assay was a simple, rapid, sensitive, and cost-effective detection method for clinical diagnosis of mixed infections of porcine diarrhea associated viruses...
  81. ncbi A trimerizing GxxxG motif is uniquely inserted in the severe acute respiratory syndrome (SARS) coronavirus spike protein transmembrane domain
    Eyal Arbely
    The Alexander Silberman Institute of Life Sciences, Department of Biological Chemistry, The Hebrew University of Jerusalem, Edmond J Safra Campus, Givat Ram, Jerusalem 91904, Israel
    Biochemistry 45:11349-56. 2006
    ..what distinguishes severe acute respiratory syndrome (SARS) coronavirus (SCoV) from other members of the coronaviridae, we searched for elements that are unique to its proteins and not present in any other family member...
  82. ncbi Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses
    Kalina T Zlateva
    Department of Medical Microbiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Virol Methods 177:174-83. 2011
    The ssRNA+ family Coronaviridae includes two subfamilies prototyped by coronaviruses and toroviruses that cause respiratory and enteric infections...
  83. ncbi Inhibitory effect of silver nanomaterials on transmissible virus-induced host cell infections
    Xiaonan Lv
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, no 59, Mucai Street, Xiangfang District, Harbin 150030, PR China National Center for Nanoscience and Technology of China, no 11, Beiyitiao, Zhongguancun, Beijing 100190, PR China
    Biomaterials 35:4195-203. 2014
    Coronaviruses belong to the family Coronaviridae, which primarily cause infection of the upper respiratory and gastrointestinal tract of hosts...
  84. pmc Examining landscape factors influencing relative distribution of mosquito genera and frequency of virus infection
    S Junglen
    Research Group Emerging Zoonoses, Robert Koch Institute, Berlin, Germany
    Ecohealth 6:239-49. 2009
    ..from the different habitats led to the isolation of five uncharacterized viruses of the families Bunyaviridae, Coronaviridae, Flaviviridae, and Rhabdoviridae, as well as an unclassified virus...
  85. pmc Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle
    Clara C Posthuma
    Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, LUMC P4 26, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Virol 80:1653-61. 2006
    ..Our data suggest that the arterivirus nsp11 is a multifunctional protein with a key role in viral RNA synthesis and additional functions in the viral life cycle that are as yet poorly defined...
  86. ncbi Cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape codon usage bias in coronaviruses
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong
    Virology 369:431-42. 2007
    ..The underlying mechanism for the extreme codon usage bias, cytosine deamination and G+C content in CoV-HKU1 warrants further studies...
  87. ncbi Epidemiological analysis of bovine torovirus in Japan
    Toshihiro Ito
    Kyoto Biken Laboratories, Inc, 24 16 Makishima cho Uji shi, Kyoto 611 0041, Japan
    Virus Res 126:32-7. 2007
    Bovine torovirus (BToV), a member of the Coronaviridae family, is an established gastrointestinal infectious agent in cattle. No epidemiological research on BToV has been reported from Japan...
  88. pmc Membrane topology of murine coronavirus replicase nonstructural protein 3
    Amornrat Kanjanahaluethai
    Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Virology 361:391-401. 2007
    Mouse hepatitis virus (MHV) is a member of the family Coronaviridae. These positive strand RNA viruses encode a replicase polyprotein that is processed into 16 nonstructural proteins (nsps)...
  89. ncbi Controversies and uncertainties in managing SARS
    Timothy H Rainer
    Expert Rev Anti Infect Ther 1:195-8. 2003
  90. ncbi Porcine respiratory coronavirus: molecular features and virus-host interactions
    H Laude
    INRA, Unite de Virologie et Immunologie Moleculaires, Jouy en Josas, France
    Vet Res 24:125-50. 1993
    ..The authors' views concerning the impact of the emergence of PRCV on both coronavirus research and swine production are presented in the conclusion...
  91. ncbi The role of bovine intraepithelial leukocyte-mediated cytotoxicity in enteric antiviral defense
    D L Godson
    Veterinary Infectious Disease Organization, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    Viral Immunol 5:1-13. 1992
    ..This type of interaction could serve to enhance the efficiency of IEL cytotoxic cells in vivo. Thus IEL-mediated cytotoxicity has the potential to serve as a mechanism of defense to enteric viral infection...
  92. ncbi Detection of Australian gill-associated virus (GAV) and lymphoid organ virus (LOV) of Penaeus monodon by RT-nested PCR
    J A Cowley
    Cooperative Research Centre for Aquaculture, CSIRO Tropical Agriculture, Indooroopilly, Australia
    Dis Aquat Organ 39:159-67. 2000
    ..The speed and sensitivity of the RT-nPCR make it a useful adjunct to TEM for diagnosing LOV/GAV infection of P. monodon, with the additional benefit that screening of gill biopsies may facilitate selection of LOV-free broodstock...
  93. pmc Identification and characterization of a porcine torovirus
    A Kroneman
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands
    J Virol 72:3507-11. 1998
    ..A porcine torovirus (PoTV) was identified and characterized; it is a novel member of the genus Torovirus (family Coronaviridae, order Nidovirales), closely related to but clearly distinct from the already recognized equine torovirus (ETV)..
  94. ncbi Evidence for a porcine respiratory coronavirus, antigenically similar to transmissible gastroenteritis virus, in the United States
    R D Wesley
    USDA, National Animal Disease Center, Ames, IA 50010
    J Vet Diagn Invest 2:312-7. 1990
    ..Radioimmunoassays with a panel of monoclonal antibodies indicated that the Indiana respiratory variant and the European PRCV are antigenically similar...
  95. ncbi Antibodies to human coronaviruses 229E and OC43 in the population of C.R
    J Hruskova
    Institute of Hygiene and Epidemiology, Prague, Czechoslovakia
    Acta Virol 34:346-52. 1990
    ..Significant antibody rises to HCV strain 229E were detected in 7 (3.2%) patients 9 months to 17 years old, to HCV strain OC43 in 4 (1.8%) patients under 2 years of age...
  96. pmc The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
    Philip A Marsden
    CIHR Group on Cellular and Molecular Mechanisms of Organ Injury, Toronto, Ontario, Canada
    J Clin Invest 112:58-66. 2003
    ..In the setting of murine hepatitis virus strain-3 (MHV-3) infection, a member of the Coronaviridae, activated endothelial cells and macrophages express distinct cell-surface procoagulants, including a novel ..
  97. ncbi Sequence analysis of the spike protein gene of murine coronavirus variants: study of genetic sites affecting neuropathogenicity
    F I Wang
    Department of Neurology, School of Medicine, University of Southern California, Los Angeles 90033
    Virology 186:742-9. 1992
    ..The sequence microheterogeneity may also contribute to the differences in their biological properties...
  98. ncbi Cloning and sequence analysis of the spike gene of porcine epidemic diarrhea virus Chinju99
    Sang Geon Yeo
    College of Veterinary Medicine, Institute of Animal Medicine, Gyeongsang National University, Chinju 660 701, Republic of Korea
    Virus Genes 26:239-46. 2003
    ..The amino acid sequence contained 27 potential sites for asparagine (N)-linked glycosylation and there was a stretch of highly hydrophobic residues at position 1,325-1,350...
  99. ncbi Comparisons of the genomic RNA of Arkansas DPI embryonic passages 10 and 100, Australian T, and Massachusetts 41 strains of infectious bronchitis virus
    G D Butcher
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610
    Avian Dis 34:253-9. 1990
    ..Fingerprinting is reliable and sensitive, and should be used in combination with other characterization methods for identifying and differentiating IBV strains...
  100. pmc Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses
    R Vlasak
    Mount Sinai School of Medicine, Department of Microbiology, New York, NY 10029
    Proc Natl Acad Sci U S A 85:4526-9. 1988
    ..These results suggest that, like influenza C viruses, human coronavirus OC43 and bovine coronavirus recognize O-acetylated sialic acid or a similar derivative as cell receptor...
  101. ncbi Induction and enhancement of feline infectious peritonitis by canine coronavirus
    F McArdle
    Department of Veterinary Pathology, University of Liverpool Field Station, Neston, Wirral, UK
    Am J Vet Res 53:1500-6. 1992
    ..In addition, sequential inoculation of cats with another strain of CCV caused lesions indistinguishable from those of FIP, without exposure at any time to FIPV...

Research Grants7

  1. Priming and fusion activation of the SARS coronavirus spike glycoprotein
    Gary R Whittaker; Fiscal Year: 2010
    ..Notably the presence of a cleavage site within S2 are very highly conserved across the Coronaviridae, and are likely to be universal features;with the fusion reaction primed by different proteases depending on ..
  2. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..A and B (Orthomyxoviridae), HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia (Poxviridae), VEE, an alphavirus (Togaviridae), and Tacaribe virus (Arenaviridae) 2...
  3. Characterizing Class 1 Fusion Proteins: Elucidation of Coronavirus fusion peptide
    IKENNA MADU; Fiscal Year: 2009
    ..IBV as a model for studying coronavirus entry since the fundamental mechanism of entry is conserved within the Coronaviridae and thus, applicable to highly pathogenic viruses like SARS-CoV...
  4. CHARACTERIZATION OF NEW PRIMATE HEPATITIS VIRUS
    RICHARD MONTALI; Fiscal Year: 1991
    ..Our preliminary findings suggest that the cause may be an enveloped virus (CHV) ultrastructurally similar to coronaviridae. We have experimentally transmitted the disease to common marmosets...
  5. Hsp70 as Dispatcher of Virus Assembly and Trafficking
    VALERIAN DOLJA; Fiscal Year: 2007
    ..Functional significance of the observed interactions will be assessed using genetic strategies targeting both Hsp70h and host proteins. ..
  6. Myosin-mediated organelle trafficking in plants
    Valerian V Dolja; Fiscal Year: 2010
    ..abstract_text> ..