newcastle disease virus

Summary

Summary: The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.

Top Publications

  1. pmc Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates
    Alexander Bukreyev
    LID, NIAID, NIH, 50 South Dr, Rm 6505, Bethesda, MD 20892 8007, USA
    J Virol 79:13275-84. 2005
  2. pmc Pathotypical characterization and molecular epidemiology of Newcastle disease virus isolates from different hosts in China from 1996 to 2005
    Zhuo ming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    J Clin Microbiol 46:601-11. 2008
  3. ncbi The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones
    Nobuko Wakamatsu
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, GA 30605, USA
    Virology 353:333-43. 2006
  4. ncbi Newcastle disease and other avian paramyxoviruses
    D J Alexander
    Central Veterinary Laboratory, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Rev Sci Tech 19:443-62. 2000
  5. pmc Influenza virus evades innate and adaptive immunity via the NS1 protein
    Ana Fernandez-Sesma
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 80:6295-304. 2006
  6. pmc Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence
    B P Peeters
    Department of Avian Virology, Institute for Animal Science and Health, 8200 AB Lelystad, The Netherlands
    J Virol 73:5001-9. 1999
  7. pmc Addition of N-glycans in the stalk of the Newcastle disease virus HN protein blocks its interaction with the F protein and prevents fusion
    Vanessa R Melanson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0122, USA
    J Virol 80:623-33. 2006
  8. ncbi Virulence of Newcastle disease virus is determined by the cleavage site of the fusion protein and by both the stem region and globular head of the haemagglutinin-neuraminidase protein
    Olav S de Leeuw
    Wageningen University and Research Centre, Animal Sciences Group, Division of Infectious Diseases, 8200 AB Lelystad, The Netherlands
    J Gen Virol 86:1759-69. 2005
  9. pmc Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells
    Mena Mansour
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 85:6015-23. 2011
  10. pmc Structure of the Newcastle disease virus F protein in the post-fusion conformation
    Kurt Swanson
    Howard Hughes Medical Institute, USA
    Virology 402:372-9. 2010

Research Grants

Detail Information

Publications306 found, 100 shown here

  1. pmc Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates
    Alexander Bukreyev
    LID, NIAID, NIH, 50 South Dr, Rm 6505, Bethesda, MD 20892 8007, USA
    J Virol 79:13275-84. 2005
    ..To address this issue, we evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is serotypically distinct from common human pathogens, as a vaccine ..
  2. pmc Pathotypical characterization and molecular epidemiology of Newcastle disease virus isolates from different hosts in China from 1996 to 2005
    Zhuo ming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    J Clin Microbiol 46:601-11. 2008
    Thirty Newcastle disease virus (NDV) strains isolated from outbreaks in China during 1996 to 2005 were characterized pathotypically and genotypically. All strains except one were velogenic...
  3. ncbi The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones
    Nobuko Wakamatsu
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, GA 30605, USA
    Virology 353:333-43. 2006
    The effect of mutations of Newcastle disease virus (NDV) fusion (F) gene, hemagglutinin-neuraminidase (HN) gene, and phosphoprotein (P) gene and HN chimeras between the virulent Beaudette C and low virulence LaSota strains on ..
  4. ncbi Newcastle disease and other avian paramyxoviruses
    D J Alexander
    Central Veterinary Laboratory, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Rev Sci Tech 19:443-62. 2000
    ..The variable nature of Newcastle disease virus strains in terms of virulence for poultry and the different susceptibilities of the different species of ..
  5. pmc Influenza virus evades innate and adaptive immunity via the NS1 protein
    Ana Fernandez-Sesma
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 80:6295-304. 2006
    ..Th1-cell stimulatory abilities than DCs activated by other stimuli, such as lipopolysaccharide and Newcastle disease virus infection...
  6. pmc Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence
    B P Peeters
    Department of Avian Virology, Institute for Animal Science and Health, 8200 AB Lelystad, The Netherlands
    J Virol 73:5001-9. 1999
    A full-length cDNA clone of Newcastle disease virus (NDV) vaccine strain LaSota was assembled from subgenomic overlapping cDNA fragments and cloned in a transcription plasmid between the T7 RNA polymerase promoter and the autocatalytic ..
  7. pmc Addition of N-glycans in the stalk of the Newcastle disease virus HN protein blocks its interaction with the F protein and prevents fusion
    Vanessa R Melanson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0122, USA
    J Virol 80:623-33. 2006
    ..Our data support the idea that the F-interactive site on HN is defined by the stalk region of the protein...
  8. ncbi Virulence of Newcastle disease virus is determined by the cleavage site of the fusion protein and by both the stem region and globular head of the haemagglutinin-neuraminidase protein
    Olav S de Leeuw
    Wageningen University and Research Centre, Animal Sciences Group, Division of Infectious Diseases, 8200 AB Lelystad, The Netherlands
    J Gen Virol 86:1759-69. 2005
    Virulence of Newcastle disease virus (NDV) is mainly determined by the amino acid sequence surrounding the fusion (F) protein cleavage site, since host proteases that cleave the F protein of virulent strains are present in more tissues ..
  9. pmc Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells
    Mena Mansour
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 85:6015-23. 2011
    b>Newcastle disease virus (NDV) is a negative-sense RNA virus that has been shown to possess oncolytic activity...
  10. pmc Structure of the Newcastle disease virus F protein in the post-fusion conformation
    Kurt Swanson
    Howard Hughes Medical Institute, USA
    Virology 402:372-9. 2010
    ..Previous studies of the Newcastle disease virus, human parainfluenza virus 3 and parainfluenza virus 5 F proteins revealed differences in the pre- and ..
  11. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    The avian paramyxovirus Newcastle disease virus (NDV) selectively replicates in tumor cells and is known to stimulate T-cell-, macrophage-, and NK cell-mediated responses...
  12. pmc Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses
    Jinying Ge
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
    J Virol 81:150-8. 2007
    ..Vaccine strains of Newcastle disease virus (NDV), however, have been used successfully to easily vaccinate large numbers of animals...
  13. ncbi A molecular epidemiological study of avian paramyxovirus type 1 (Newcastle disease virus) isolates by phylogenetic analysis of a partial nucleotide sequence of the fusion protein gene
    E W Aldous
    Virology Department Veterinary Laboratories Agency Weybridge New Haw, Addlestone KT15 3NB Surrey, UK
    Avian Pathol 32:239-56. 2003
    ..activation site and signal peptide of the fusion protein gene, was determined for 174 isolates of Newcastle disease virus (avian paramyxovirus type 1)...
  14. pmc Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk
    Ping Yuan
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:14920-5. 2011
    ..Mutations of the Newcastle disease virus HN stalk region have been shown to affect both F activation and NA activities, but a structural basis for ..
  15. pmc Experimental infection of mice with avian paramyxovirus serotypes 1 to 9
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 6:e16776. 2011
    ..APMV-1, also called Newcastle disease virus, was shown to be attenuated in non-avian species and is being developed as a potential vector for human ..
  16. pmc Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:1501-11. 2003
    We have generated a recombinant Newcastle disease virus (NDV) that expresses the green fluorescence protein (GFP) in infected chicken embryo fibroblasts (CEFs)...
  17. pmc Newcastle disease virus exerts oncolysis by both intrinsic and extrinsic caspase-dependent pathways of cell death
    Subbiah Elankumaran
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 80:7522-34. 2006
    b>Newcastle disease virus (NDV), an avian paramyxovirus, is tumor selective and intrinsically oncolytic...
  18. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011
    ..However, VLPs composed of the Newcastle disease virus (NDV) nucleocapsid and membrane proteins and chimera proteins containing the ectodomains of RSV F and G ..
  19. pmc Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Vaccine 28:3159-70. 2010
    ....
  20. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a multifunctional protein that plays a crucial role in virus infectivity...
  21. ncbi Evaluation of Newcastle disease virus chimeras expressing the Hemagglutinin-Neuraminidase protein of velogenic strains in the context of a mesogenic recombinant virus backbone
    Carlos Estevez
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA
    Virus Res 129:182-90. 2007
    A major factor in the pathogenicity of Newcastle disease virus (NDV) is the amino acid sequence of the fusion protein cleavage site, but the role of other viral genes that contribute to virulence and different clinical forms of the ..
  22. pmc Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV
    Olivier F Maminiaina
    FOFIFA DRZV, Antananarivo, Madagascar
    PLoS ONE 5:e13987. 2010
    ..However, the potential implication in vaccination failures of specific amino acid substitutions predominantly found on surface-exposed epitopes of F and HN proteins is discussed...
  23. pmc Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responses
    Elena Carnero
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 83:584-97. 2009
    ..of viral vectors with a proven safety profile and an absence of preexisting immunity in humans, such as Newcastle disease virus (NDV)...
  24. ncbi Phylogenetic characterization of Newcastle disease virus isolated in the mainland of China during 2001-2009
    Zhang Rui
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Vet Microbiol 141:246-57. 2010
    Twenty Newcastle disease virus (NDV) isolates from infected chicken flocks during 2001 to 2009 in China were biologically and genetically characterized...
  25. pmc Amino acid substitutions in the F-specific domain in the stalk of the newcastle disease virus HN protein modulate fusion and interfere with its interaction with the F protein
    Vanessa R Melanson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 0122, USA
    J Virol 78:13053-61. 2004
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus mediates attachment to sialic acid receptors, as well as cleavage of the same moiety...
  26. pmc Phylogenetic analysis of Newcastle disease virus genotypes isolated in Japan
    Masaji Mase
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Clin Microbiol 40:3826-30. 2002
    ..It can be concluded from this study that ND outbreaks in Japan have been of multiple etiologies. [All sequences used in this study were sent to DDBJ and assigned accession numbers AB 070382 to AB 074042.]..
  27. pmc A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells
    Jianzhong Hu
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 185:424-32. 2010
    Infection of human dendritic cells (DCs) by negative-strand RNA viruses, such as Newcastle disease virus, leads to the induction of the IFNbeta gene, IFNB1, through the activation of the RNA helicase RIG-I, which is encoded by DDX58...
  28. ncbi A vaccine candidate of attenuated genotype VII Newcastle disease virus generated by reverse genetics
    Shunlin Hu
    Animal Infectious Disease Laboratory, Yangzhou University, Yangzhou, Jiangsu 225009, China
    Vaccine 27:904-10. 2009
    Genotype VII Newcastle disease virus (NDV) has been documented as the predominant epidemic genotype in China and some other Asian countries since 1990s...
  29. ncbi Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer
    Volker Schirrmacher
    Division of Cellular Immunology D010, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 542:565-605. 2009
    This review deals with the avian paramyxovirus Newcastle disease virus (NDV) and describes properties that explain its oncolytic activity, its tumor-selective replication behavior, and its immune-stimulatory capacity with human cells...
  30. pmc Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells
    Jianzhong Hu
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
    Nucleic Acids Res 35:5232-41. 2007
    ....
  31. ncbi Role of fusion protein cleavage site in the virulence of Newcastle disease virus
    Aruna Panda
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    Microb Pathog 36:1-10. 2004
    b>Newcastle disease virus (NDV) causes a highly contagious and economically important disease in poultry. Viral determinants of NDV virulence are not completely understood...
  32. pmc Recombinant Newcastle disease virus as a vaccine vector
    T Nakaya
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 75:11868-73. 2001
    A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics...
  33. pmc Characterization of newly emerging Newcastle disease virus isolates from the People's Republic of China and Taiwan
    L Yu
    Animal Health Biotechnology Laboratory, Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
    J Clin Microbiol 39:3512-9. 2001
    ..Finally, a cross-protective experiment indicated that at least one strain (Ch-A7/96) among our NDV isolates was an antigenic variant, responsible for recent outbreaks of ND in vaccinated chicken flocks...
  34. pmc Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza
    Jutta Veits
    Institute of Molecular Biology, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Boddenblick 5a, D 17493 Greifswald Insel Riems, Germany
    Proc Natl Acad Sci U S A 103:8197-202. 2006
    b>Newcastle disease virus (NDV)-expressing avian influenza virus (AIV) hemagglutinin (HA) of subtype H5 was constructed by reverse genetics...
  35. ncbi Experimental pathogenesis for chickens, turkeys, and pigeons of exotic Newcastle disease virus from an outbreak in California during 2002-2003
    N Wakamatsu
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Vet Pathol 43:925-33. 2006
    Exotic Newcastle disease virus (NDV) isolated from chickens during the 2002-2003 California outbreak (CA exotic Newcastle disease [END] virus) was inoculated into 4-week-old specific-pathogen-free (SPF) White Leghorn chickens, 3-week-old ..
  36. ncbi Newcastle disease in geese: natural occurrence and experimental infection
    Hongquan Wan
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Jiangsu, China
    Avian Pathol 33:216-21. 2004
    ..This is the first detailed report of the natural outbreaks and experimental reproduction of ND in geese, providing evidence that geese could play an important role in the epidemiology of ND...
  37. pmc The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein Livin
    Itay Lazar
    Department of Virology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Virol 84:639-46. 2010
    ..study, we applied a novel approach for the treatment of melanoma, using a unique strain of the oncolytic Newcastle disease virus (NDV-HUJ)...
  38. ncbi Pathogenesis of chicken-passaged Newcastle disease viruses isolated from chickens and wild and exotic birds
    Glaucia D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D W Brooks Drive, Athens, GA 30602 7388, USA
    Avian Dis 47:319-29. 2003
    The pathogenesis of six Newcastle disease virus (NDV) isolates recovered from chickens (Ckn-LBM and Ckn-Australia) and wild (Anhinga) and exotic (YN parrot, pheasant, and dove) birds was examined after the isolates had been passaged four ..
  39. pmc Complete genome and clinicopathological characterization of a virulent Newcastle disease virus isolate from South America
    Diego G Diel
    USDA, ARS, Southeast Poultry Research Laboratory, Athens, Georgia, USA
    J Clin Microbiol 50:378-87. 2012
    ..The disease is caused by Newcastle disease virus (NDV) or avian paramyxovirus type 1 (APMV-1), a negative-sense single-stranded RNA virus of the genus ..
  40. pmc Phylogenetic and biological characterization of Newcastle disease virus isolates from Pakistan
    Taseer Ahmed Khan
    USDA ARS, Southeast Poultry Research Laboratory, 934 College Station Rd, Athens, GA 30605, USA
    J Clin Microbiol 48:1892-4. 2010
    Eight Newcastle disease virus isolates from Pakistan were sequenced and characterized. A PCR matrix gene assay, designed to detect all avian paramyxovirus 1, did not detect four of the isolates...
  41. ncbi Clinicopathological characterization in poultry of three strains of Newcastle disease virus isolated from recent outbreaks
    L Susta
    Department of Veterinary Pathology, CVM, UGA, Athens, GA 30602 7388, USA
    Vet Pathol 48:349-60. 2011
    Newcastle disease is a severe threat to the poultry industry and is caused by Newcastle disease virus, a member of the genus Avulavirus, family Paramyxoviridae...
  42. ncbi Gordon Memorial Lecture. Newcastle disease
    D J Alexander
    Br Poult Sci 42:5-22. 2001
    ..5. Village chickens are extremely important assets in most developing countries, representing a significant source of protein in the form of eggs and meat but endemic ND can cause mortality of up to 60% in village chickens...
  43. pmc Entire genome sequence analysis of genotype IX Newcastle disease viruses reveals their early-genotype phylogenetic position and recent-genotype genome size
    Xusheng Qiu
    Key Laboratory of Animal Infectious Diseases, Yangzhou University, Yangzhou 225009, PR China
    Virol J 8:117. 2011
    ..However, F48-like NDVs from China, identified a 6-nt insert in the NP gene, have been previously classified into genotype III or genotype IX...
  44. ncbi Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine
    Zhenhuan Guo
    Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vaccine 27:660-5. 2009
    ..sLNT(2) possessed the best efficacy and would be expected as the candidate of a new-type immune adjuvant...
  45. ncbi Analysis of codon usage in Newcastle disease virus
    Meng Wang
    Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046 Gansu, People s Republic of China
    Virus Genes 42:245-53. 2011
    ..dinucleotide were used to investigate codon usage pattern of each protein-coding gene and genome among 31 Newcastle disease virus (NDV) isolates...
  46. pmc Protective efficacy of commercial inactivated Newcastle disease virus vaccines in chickens against a recent Korean epizootic strain
    Woo Jin Jeon
    Avian Disease Division, National Veterinary Research Institute, National Veterinary Research and Quarantine Service, Anyang 430 824, Korea
    J Vet Sci 9:295-300. 2008
    Despite the intensive vaccination policy that has been put in place to control Newcastle disease virus (NDV), the recent emergence of NDV genotype VII strains in Korea has led to significant economic losses in the poultry industry...
  47. pmc The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e12151. 2010
    ..Here we report further studies to determine the antiviral potential of chicken Mx against Newcastle disease virus (NDV), an economically important cytoplasmic RNA virus of chickens, and Thogoto virus, an orthomyxovirus ..
  48. ncbi Whole genome sequencing and characterization of a virulent Newcastle disease virus isolated from an outbreak in Sweden
    Muhammad Munir
    The Department of Biomedical Sciences and Veterinary Public Health, Division of Virology and Parasitology and Joint Research and Development, National Veterinary Institute SVA, Uppsala, Sweden
    Virus Genes 43:261-71. 2011
    In this study, the complete genome sequence of a Newcastle disease virus (NDV) isolate collected from an outbreak in 1995 in chickens was fully characterized and compared with other NDV sequences...
  49. ncbi HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells
    P V Ravindra
    Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, India
    Arch Virol 153:749-54. 2008
    b>Newcastle disease virus (NDV), an avian paramyxovirus, induces apoptosis in chicken embryo fibroblast (CEF) cells...
  50. pmc Artificial recombination may influence the evolutionary analysis of Newcastle disease virus
    Qingqing Song
    College of Veterinary Medicine, Yangzhou University, Yangzhou, China
    J Virol 85:10409-14. 2011
    The recombination rate in Newcastle disease virus (NDV) was as high as 10% in RDP analysis with full-length NDV genome sequences available in GenBank...
  51. ncbi Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus
    Charlotte Ryan
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland, UK
    Glycoconj J 23:135-41. 2006
    ..viruses (hPIV) are members of the Paramyxovirinae subfamily, which also includes mumps virus, Newcastle disease virus (NDV), Sendai virus (SV) and simian type 5 virus (SV5)...
  52. ncbi Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo
    Songshu Meng
    State Key Laboratory of Veterinary Biotechnology, Harbin 150001, China
    Cancer Lett 317:56-64. 2012
    ..This study aims to investigate whether Newcastle disease virus (NDV) exhibits an oncolytic effect on cisplatin-resistant A549 lung cancer cells...
  53. ncbi Complete genome analysis of an avian paramyxovirus type 1 strain isolated in 1994 from an asymptomatic black-headed gull (Larus ridibundus) in southern Sweden
    Muhammad Munir
    Joint Research and Development Unit for Virology, Immunobiology and Parasitology of the National Veterinary Institute SVA and Swedish University of Agricultural Sciences SLU, Department of Biomedical Sciences and Veterinary Public Health, Division of Microbiology and Food Safety, Ulls Väg 2B, SE 751 89 Uppsala, Sweden
    Avian Dis 54:923-30. 2010
    ..Waterfowl have been considered to act as a reservoir for APMV-1 and, therefore, it is important to broaden the knowledge of viruses circulating within this population...
  54. ncbi Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus
    J Puhlmann
    Bayer Schering Pharma AG, Global Drug Discovery, Berlin, Germany
    Oncogene 29:2205-16. 2010
    Oncolytic Newcastle disease virus (NDV) replicates selectively in most human tumor cells but not in normal cells...
  55. ncbi Pathogenesis of six pigeon-origin isolates of Newcastle disease virus for domestic chickens
    G D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602 7388, USA
    Vet Pathol 39:353-62. 2002
    The pathogenesis of six pigeon-origin isolates of Newcastle disease virus (NDV) was investigated in chickens...
  56. ncbi Newcastle disease virus therapy of human tumor xenografts: antitumor effects of local or systemic administration
    A Phuangsab
    Department of Surgery, Cook County Hospital, 627 South Wood Street, Chicago, IL 60612, USA
    Cancer Lett 172:27-36. 2001
    Previously we showed that a single local injection of the avian paramyxovirus Newcastle disease virus (NDV) strain 73-T caused long-lasting, complete tumor regression of human neuroblastoma and fibrosarcoma xenografts in athymic mice...
  57. pmc Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells
    Jianzhong Hu
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e16614. 2011
    ..The results suggest that large cell-to-cell variation plays an important role in the early innate immune response, and that the variability is essential for the efficient activation of the IFNB1 based feedback loop...
  58. ncbi Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe
    Jenny Almkvist
    The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    Exp Cell Res 298:74-82. 2004
    ..NA) of different origins: Clostridium perfringens (CP), Salmonella typhimurium, Vibrio cholerae, and Newcastle disease virus (NDV)...
  59. ncbi Newcastle diseases virus strain V4UPM displayed oncolytic ability against experimental human malignant glioma
    M M Zulkifli
    Department of Neurosciences, School of Medical Science, University Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Neurol Res 31:3-10. 2009
    b>Newcastle disease virus (NDV) is a virus of paramyxovirus family and lately has been studied for the treatment of cancer in human...
  60. ncbi The P gene of Newcastle disease virus does not encode an accessory X protein
    Ben Peeters
    Division of Infectious Diseases, Animal Sciences Group, Wageningen University and Research Centre, PO Box 65, NL 8200 AB Lelystad, The Netherlands
    J Gen Virol 85:2375-8. 2004
    ..It has been suggested that the P gene mRNA of Newcastle disease virus (NDV) encodes an accessory protein - the so-called X protein - by translation initiation at a conserved ..
  61. ncbi In vivo efficacy of systemic tumor targeting of a viral RNA vector with oncolytic properties using a bispecific adapter protein
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Oncol 29:1359-69. 2006
    The aim of the study was: i) to specifically target tumor tissue by Newcastle disease virus (NDV) with oncolytic properties, ii) to improve the delivery system for systemic application of NDV via a bispecific adapter protein and iii) to ..
  62. ncbi Genotyping of Newcastle disease viruses isolated from 2001 to 2007 in Japan
    Masaji Mase
    National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 71:1101-4. 2009
    Seventeen isolates of Newcastle disease virus (NDV) were obtained from various prefectures in Japan during the years 2001-2007 and were genotypically analyzed by the reverse transcriptase-polymerase chain reaction (RT-PCR) method coupled ..
  63. ncbi Newcastle disease virus as a vaccine vector for humans
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Infectious Disease, 50 South Drive, Bethesda, MD 20892, USA
    Curr Opin Mol Ther 10:46-55. 2008
    ..b>Newcastle disease virus (NDV) is an enveloped cytoplasmic RNA virus of avian origin that is highly attenuated in humans and other ..
  64. pmc Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 83:5943-6. 2009
    To determine the role of untranslated regions (UTRs) in replication and pathogenesis of Newcastle disease virus (NDV), we generated recombinant viruses with deletions in 5' and 3' UTRs of the HN mRNA...
  65. ncbi Generation of recombinant lentogenic Newcastle disease virus from cDNA
    A Romer-Oberdorfer
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D 17498 Insel Riems
    J Gen Virol 80:2987-95. 1999
    Recombinant lentogenic Newcastle disease virus (NDV) of the vaccine strain Clone-30 was reproducibly generated after simultaneous expression of antigenome-sense NDV RNA and NDV nucleoprotein, phosphoprotein and RNA-dependent RNA ..
  66. ncbi Ultrastructural changes of the tracheal epithelium after vaccination of day-old chickens with the La Sota strain of Newcastle disease virus
    J Mast
    Veterinary and Agrochemical Research Center, Brussels, Belgium
    Vet Pathol 42:559-65. 2005
    ..lesions induced by vaccination of day-old specific pathogen-free chicks with the La Sota strain of Newcastle disease virus (NDV) was examined by relating surface changes as observed by scanning electron microscopy with ..
  67. ncbi Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme
    Arnold I Freeman
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem 91120, Israel
    Mol Ther 13:221-8. 2006
    ..and tumor response of repetitive intravenous administration of NDV-HUJ, the oncolytic HUJ strain of Newcastle disease virus. The first part of the study utilized an accelerated intrapatient dose-escalation protocol with one-cycle ..
  68. pmc Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: implications for the mechanism of fusion promotion
    Paul J Mahon
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 82:10386-96. 2008
    The promotion of membrane fusion by Newcastle disease virus (NDV) requires an interaction between the viral hemagglutinin-neuraminidase (HN) and fusion (F) proteins, although the mechanism by which this interaction regulates fusion is ..
  69. pmc Characterization of class I Newcastle disease virus isolates from Hong Kong live bird markets and detection using real-time reverse transcription-PCR
    L Mia Kim
    Southeast Poultry Research Laboratory, USDA ARS, 934 College Station Rd, Athens, GA 30605, USA
    J Clin Microbiol 45:1310-4. 2007
    ..S. LBMs and wild waterfowl. An alternative real-time RT-PCR assay which complements the matrix gene assay was developed to efficiently detect class I viruses...
  70. ncbi Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D010, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Gene Ther 12:295-303. 2005
    We developed a novel strategy to target recombinant Newcastle disease virus (NDV) to tumor cells for gene therapy...
  71. ncbi Identification of a variable epitope on the Newcastle disease virus hemagglutinin-neuraminidase protein
    Shunlin Hu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, 48 East Wenhui Road, Yangzhou 225009, China
    Vet Microbiol 140:92-7. 2010
    ..Further verification by immunofluorescent assay demonstrated that residue 347 was a critical determinant for formation of the antigenic epitope (residues 345-353) on the HN protein...
  72. ncbi Isolation and analysis of two naturally-occurring multi-recombination Newcastle disease viruses in China
    Rui Zhang
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Virus Res 151:45-53. 2010
    ..The potential role of swine-origin viruses in the evolution of virulent NDV warrants further investigation...
  73. ncbi Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive tract
    Wei Liang
    Liaoning Provincal Tumor Research Institute, 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China
    World J Gastroenterol 9:495-8. 2003
    To treat patients with stage I-IV malignant tumors of digestive tract using autologous tumor cell vaccine and NDV (Newcastle disease virus) vaccine, and observe the survival period and curative effect.
  74. ncbi Generation of a velogenic Newcastle disease virus from cDNA and expression of the green fluorescent protein
    Y L Liu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, PR China
    Arch Virol 152:1241-9. 2007
    b>Newcastle disease virus (NDV) is a pathogen that is important in the poultry industry worldwide. Specifically, the virulent (velogenic) NDV is a particular threat because it has now occurred frequently worldwide...
  75. ncbi Virulence of pigeon-origin Newcastle disease virus isolates for domestic chickens
    G D Kommers
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602-7388, USA
    Avian Dis 45:906-21. 2001
    The virulence of six pigeon-origin isolates of Newcastle disease virus (NDV) was evaluated before and after passage in white leghorn chickens...
  76. pmc The viral replication complex is associated with the virulence of Newcastle disease virus
    J C F M Dortmans
    Central Veterinary Institute of Wageningen UR, Lelystad, Netherlands
    J Virol 84:10113-20. 2010
    Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the ..
  77. ncbi Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence
    J C F M Dortmans
    Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    J Gen Virol 92:336-45. 2011
    Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals...
  78. ncbi Genetic parameters for body weights, egg traits and antibody response against Newcastle Disease Virus (NDV) vaccine among two Tanzania chicken ecotypes
    J Lwelamira
    Institute of Rural Development Planning, P O Box 138, Dodoma, Tanzania
    Trop Anim Health Prod 41:51-9. 2009
    ..The magnitudes of heritability estimates obtained in this study indicate good prospects of improving these traits in both ecotypes through selection...
  79. pmc Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses
    Dmitriy Zamarin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Ther 17:697-706. 2009
    b>Newcastle disease virus (NDV) has been previously shown to possess oncolytic activity, causing specific lysis of cancerous but not normal cells...
  80. ncbi Sequence variation in the Newcastle disease virus genome
    Jacqueline A Kattenbelt
    CSIRO Livestock Industries, Australian Animal Health Laboratory, P O Bag 24, Geelong, Victoria 3220, Australia
    Virus Res 116:168-84. 2006
    Full-length genome sequences of five virulent and five avirulent strains of Newcastle disease virus isolated between 1998 and 2002 in Victoria and New South Wales, Australia were determined...
  81. pmc Immunization of chickens with Newcastle disease virus expressing H5 hemagglutinin protects against highly pathogenic H5N1 avian influenza viruses
    Baibaswata Nayak
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 4:e6509. 2009
    Highly-pathogenic avian influenza virus (HPAIV) and Newcastle disease virus (NDV) are the two most important poultry viruses in the world...
  82. pmc Loop-mediated isothermal amplification for rapid detection of Newcastle disease virus
    Hang Minh Pham
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Clin Microbiol 43:1646-50. 2005
    ..the loop-mediated isothermal amplification (LAMP) assay for the rapid, simple, and sensitive detection of Newcastle disease virus (NDV) directly from culture isolates as well as clinical samples...
  83. ncbi Pathotypical and genotypical characterization of strains of Newcastle disease virus isolated from outbreaks in chicken and goose flocks in some regions of China during 1985-2001
    X F Liu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China
    Arch Virol 148:1387-403. 2003
    Twenty-nine strains of Newcastle disease virus (NDV) isolated from outbreaks in chicken and goose flocks in several regions of China during 1985-2001 were characterized pathotypically and genotypically...
  84. pmc Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 MSC, USA
    Vaccine 29:17-25. 2010
    ..Here we developed a new vaccine candidate (NDV/GP) based on Newcastle disease virus (NDV), an avian paramyxovirus that is antigenically distinct from human viral pathogens and is highly ..
  85. ncbi Human tumor cell infection by Newcastle Disease Virus leads to upregulation of HLA and cell adhesion molecules and to induction of interferons, chemokines and finally apoptosis
    B Washburn
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 21:85-93. 2002
    In order to analyse immune-stimulatory effects of infection of human tumor cells with Newcastle Disease Virus (NDV), gamma-irradiated human breast carcinoma, colon-carcinoma or glioblastoma cells from defined cell lines were modified ..
  86. ncbi Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus
    ADAM VIGIL
    Department of Microbiology, Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Res 67:8285-92. 2007
    Naturally occurring strains of Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials...
  87. ncbi Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells
    Yutaro Kumagai
    World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan
    J Immunol 182:3960-4. 2009
    ..By checking Newcastle disease virus (NDV) RNA abundance in GFP(+) and GFP(-) pDCs from Ifna6gfp mice, we found that NDV replication was not ..
  88. pmc Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300
    M Yoneyama
    Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Japan
    EMBO J 17:1087-95. 1998
    ..These findings suggest that IRF-3 plays an important role in the virus-inducible primary activation of type I IFN and IFN-responsive genes...
  89. ncbi Avian influenza and Newcastle disease viruses from northern pintail in Japan: isolation, characterization and inter-annual comparisons during 2006-2008
    Alam Jahangir
    Laboratory of Zoonoses, School of Veterinary Medicine, Kitasato University, 35 1 Higasi, 23 Bancho, Towadashi, Aomori, 034 8628, Japan
    Virus Res 143:44-52. 2009
    ..We also provide evidence that this host carries APMV-1: Newcastle disease virus (NDV) and other haemagglutinating viruses...
  90. ncbi Newcastle disease virus may enter cells by caveolae-mediated endocytosis
    Celia Cantín
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental Lab 108, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
    J Gen Virol 88:559-69. 2007
    The entry into cells of Newcastle disease virus (NDV), a prototype member of the paramyxoviruses, is believed to occur by direct fusion at the plasma membrane through a pH-independent mechanism...
  91. pmc The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence
    Zhuhui Huang
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 78:4176-84. 2004
    The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays a crucial role in the process of infection. However, the exact contribution of the HN gene to NDV pathogenesis is not known...
  92. ncbi Newcastle disease: evolution of genotypes and the related diagnostic challenges
    Patti J Miller
    Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30052, USA
    Infect Genet Evol 10:26-35. 2010
    Since the discovery of Newcastle disease virus (NDV) in 1926, nine genotypes of class I viruses and ten of class II have been identified, representing a diverse and continually evolving group of viruses...
  93. pmc Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines
    Sateesh Krishnamurthy
    Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    J Virol 80:5145-55. 2006
    b>Newcastle disease virus (NDV) is a negative-strand RNA virus with oncolytic activity against human tumors. Its effectiveness against tumors and safety in normal tissue have been demonstrated in several clinical studies...
  94. ncbi Genomic sequences of low-virulence avian paramyxovirus-1 (Newcastle disease virus) isolates obtained from live-bird markets in North America not related to commonly utilized commercial vaccine strains
    Bruce S Seal
    Southeast Poultry Research Laboratory, U S Department of Agriculture, Agricultural Research Service, 934 College Station Road, Athens, GA 360605, USA
    Vet Microbiol 106:7-16. 2005
    Avian paramyxovirus 1 (APMV-1), also referred to as Newcastle disease virus (NDV), variants of low virulence were isolated from chickens, ducks and other unidentified species found in live-bird markets of the northeastern United States...
  95. pmc Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion
    Viatcheslav Zaitsev
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom
    J Virol 78:3733-41. 2004
    ..Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and ..
  96. pmc The large polymerase protein is associated with the virulence of Newcastle disease virus
    Subrat N Rout
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 82:7828-36. 2008
    Naturally occurring Newcastle disease virus (NDV) strains vary greatly in virulence, ranging from no apparent infection to severe disease causing 100% mortality in chickens...
  97. pmc A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Vaccine 26:522-31. 2008
    The protection of poultry from H5N1 highly pathogenic avian influenza A (HPAI) and Newcastle disease virus (NDV) can be achieved through vaccination, as part of a broader disease control strategy...
  98. pmc Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens
    Joshua M DiNapoli
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9788-93. 2007
    ..We evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is highly attenuated in primates, as a topical respiratory vaccine ..
  99. pmc Phylogenetic diversity among low-virulence newcastle disease viruses from waterfowl and shorebirds and comparison of genotype distributions to those of poultry-origin isolates
    L Mia Kim
    USDA ARS SouthEast Poultry Research Laboratory, Athens, GA 30605, USA
    J Virol 81:12641-53. 2007
    ....
  100. pmc Mutated form of the Newcastle disease virus hemagglutinin-neuraminidase interacts with the homologous fusion protein despite deficiencies in both receptor recognition and fusion promotion
    Jianrong Li
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0122, USA
    J Virol 78:5299-310. 2004
    The Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein mediates attachment to cellular receptors. The fusion (F) protein promotes viral entry and spread...
  101. pmc Role of thiol/disulfide exchange in newcastle disease virus entry
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 83:241-9. 2009
    b>Newcastle disease virus (NDV) entry into host cells is mediated by the hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins...

Research Grants25

  1. Newcastle Disease Virus Vectored Vaccines for Norovirus Infection
    Siba K Samal; Fiscal Year: 2013
    ..To overcome these obstacles, live vectored vaccine can be an attractive approach. Newcastle disease virus (NDV), an avian paramyxovirus, vectored vaccines have shown encouraging results for vaccinations against ..
  2. MODULATION OF INNATE AND ADAPTIVE IMMUNITY BY DENGUE VIRUS
    Ana Fernandez-Sesma; Fiscal Year: 2012
    ..We will generate recombinant Newcastle disease virus (NDV) expressing individual DenV proteins and will infect DCs and other blood APCs...
  3. Phase I Clinical Translation Trial of Oncolytic rVSV-F Virotherapy for HCC
    Savio L Woo; Fiscal Year: 2010
    ..a recombinant VSV that expresses a genetically modified fusogenic membrane glycoprotein of the Newcastle disease virus (rVSV-F) and showed that through hepatic artery infusion, it infected and replicated extensively in multi-..
  4. NDV-vectored Lyme disease vaccines
    Siba K Samal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to evaluate the use of the Newcastle disease virus (NDV) as a delivery vector for host immunization with borrelial antigens as vaccine targets...
  5. Newcastle disease virus vectored HIV vaccines
    Siba K Samal; Fiscal Year: 2013
    ..We have chosen to use APMV-1, also known as Newcastle disease virus (NDV), because this is the most studied member among APMVs...
  6. A Novel Approach to RSV Vaccination
    Joan E Durbin; Fiscal Year: 2013
    ..a new approach to RSV vaccine design we made use of a viral vector derived from an avian paramyxovirus, Newcastle disease virus (NDV), chosen because it is known to be a very strong trigger for IFN-α/βproduction in ..
  7. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
    ..of RSV upper airway infection, and have used these to test a new RSV vaccine candidate: a recombinant Newcastle disease virus vector expressing the RSV F protein...
  8. Activation and Inhibition of Apoptotic Pathways by SV5
    Biao He; Fiscal Year: 2007
    ..important human and animal pathogens such as respiratory syncytial virus, measles virus, imumps virus and Newcastle disease virus. Apoptosis play an important role in the pathogenesis of paramyxoviruses, but the mechanisms of ..
  9. MOLECULAR BIOLOGY OF NDV MEMBRANE PROTEINS
    RONALD IORIO; Fiscal Year: 1993
    b>Newcastle disease virus (NDV) is the model for important, but difficult to study paramyxoviruses like measles, mumps, and respiratory syncytial viruses...
  10. CYTOKINE GENE EXPRESSION BY VIRUS IN GLIAL CELLS
    MOON SHIN; Fiscal Year: 2000
    ..We will use Newcastle Disease virus (NDV) and measles virus (MV)...
  11. Prime/Boost Immunization against HIV-1 by Viral Vectors
    Matthias Schnell; Fiscal Year: 2003
    ..attenuated, replication-competent rabies virus (RV), influenza A virus (FluA), and replication-deficient Newcastle disease virus (NDV)...
  12. MOLECULAR GENETICS OF INTESTINAL DEVELOPMENT
    Jeffrey Gordon; Fiscal Year: 1999
    ..by expressing (i) influenza C virus 9-0-acetyl-5-N-acetyl-neuraminic acid-specific esterase, the Newcastle Disease virus N-acetyl-neuraminidase (sialidase) a human alpha1,2 specific fucosyltransferase, and a human alpha1,3/4 ..
  13. Paramyxovirus Entry
    TRUDY MORRISON; Fiscal Year: 2001
    The goal of our studies is to understand the molecular mechanisms of paramyxovirus membrane fusion using Newcastle disease virus as a prototype. As in most paramyxovirus systems, membrane fusion requires both HN and F proteins...
  14. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005
    ..The goal of our studies is to understand the molecular mechanisms of paramyxovirus membrane fusion using Newcastle disease virus as a prototype. As in most paramyxovirus systems, membrane fusion requires both HN and F proteins...
  15. NDV INFECTION: ANALYSIS AT THE SUBCELLULAR LEVEL
    Lawrence Hightower; Fiscal Year: 1980
    ..chicken embryo cells by temperature-sensitive and noncytopathic mutants of a virulent strain of Newcastle disease virus. The objective of the proposed study is to identify and characterize mutants with defects in viral ..
  16. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    ADAM VIGIL; Fiscal Year: 2006
    ..this proposal, the outlined experiments aim at providing an integrated view of the oncolytic potential of Newcastle Disease Virus and the elicited host immune response as an important player in tumor therapy...
  17. NEUTRALIZATION OF NDV BY MONOCLONAL ANTIBODIES
    RONALD IORIO; Fiscal Year: 1991
    Previous work suggests that neutralization of Newcastle disease virus (NDV) by a panel of monoclonal antibodies (MAbs) specific for its HN glycoprotein requires the addition of MAbs to four sites having different functional inhibition ..
  18. TLRs in Innate Immunity to Viral Infection
    Robert Finberg; Fiscal Year: 2006
    ..will define the pathophysiology of the innate immune response to RSV and other viral pathogens, including Newcastle disease virus and polyoma virus...
  19. STRUCTURE AND EXPRESSION OF THE PARAMYXOVIRUS SV5 GENOME
    Robert A Lamb; Fiscal Year: 2010
    ..virus type 1 (hPIV1), type 2, type 3, type 5 (also know as simian virus 5 [SV5]), Sendai virus, Newcastle disease virus, measles virus, canine distemper virus, rinderpest virus, respiratory syncytial virus, human ..
  20. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  21. TARGETING ANGIOGENESIS WITH PROTEASE ACTIVATABLE VECTORS
    Stephen Russell; Fiscal Year: 2002
    ..abstract_text> ..
  22. Protease Activation of Newcastle Disease Virus for Oncolytic viral therapy
    ELANKUMARAN SUBBIAH; Fiscal Year: 2008
    ..strategies in vogue largely rely upon the natural tumor selectivity of certain viruses, such as Newcastle disease virus (NDV), and Vesicular stomatitis virus (VSV)...
  23. HTS for Small Molecule Modulators of EB Virus Protein-Protein Interactions
    Theodore Jardetzky; Fiscal Year: 2007
    ..The proposed research will allow for the identification of inhibitors of the virus entry into cells, potentially opening up new therapeutic routes to preventing EBV infection and transformation of susceptible human cells. [unreadable]..
  24. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..