filoviridae

Summary

Summary: A family of viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLA-LIKE VIRUSES and MARBURG-LIKE VIRUSES.

Top Publications

  1. ncbi Filoviruses. A compendium of 40 years of epidemiological, clinical, and laboratory studies
    Jens H Kuhn
    New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
    Arch Virol Suppl 20:13-360. 2008
  2. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
  3. pmc Filovirus vaccines
    Steven B Bradfute
    United States Army Medical Research Institute of Infectious Diseases, National Interagency Biodefense Campus Fort Detrick, Frederick, MD, USA
    Hum Vaccin 7:701-11. 2011
  4. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
  5. pmc Comprehensive panel of real-time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses
    Adrienne R Trombley
    Diagnostic Systems Division, and Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21701 5011, USA
    Am J Trop Med Hyg 82:954-60. 2010
  6. ncbi Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity
    Anthony Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S251-8. 2007
  7. pmc Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
    John M Dye
    Division of Virology, US Army Medical Research Institute for Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 109:5034-9. 2012
  8. ncbi LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
    Thomas Gramberg
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
    Virology 340:224-36. 2005
  9. pmc Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections
    Dana L Swenson
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Vaccine Immunol 15:460-7. 2008
  10. ncbi Outbreaks of filovirus hemorrhagic fever: time to refocus on the patient
    Daniel G Bausch
    Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    J Infect Dis 196:S136-41. 2007

Detail Information

Publications154 found, 100 shown here

  1. ncbi Filoviruses. A compendium of 40 years of epidemiological, clinical, and laboratory studies
    Jens H Kuhn
    New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
    Arch Virol Suppl 20:13-360. 2008
  2. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
    The taxonomy of the family Filoviridae (marburgviruses and ebolaviruses) has changed several times since the discovery of its members, resulting in a plethora of species and virus names and abbreviations...
  3. pmc Filovirus vaccines
    Steven B Bradfute
    United States Army Medical Research Institute of Infectious Diseases, National Interagency Biodefense Campus Fort Detrick, Frederick, MD, USA
    Hum Vaccin 7:701-11. 2011
    ..Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed...
  4. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
    ..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
  5. pmc Comprehensive panel of real-time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses
    Adrienne R Trombley
    Diagnostic Systems Division, and Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21701 5011, USA
    Am J Trop Med Hyg 82:954-60. 2010
    ..by a diverse group of single-stranded, negative-sense or positive-sense RNA viruses belonging to the families Filoviridae (Ebola and Marburg), Arenaviridae (Lassa, Junin, Machupo, Sabia, and Guanarito), and Bunyaviridae (hantavirus)...
  6. ncbi Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity
    Anthony Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S251-8. 2007
    ..These observations obtained using wild-type viruses confirm the results of studies utilizing recombinant systems and offer additional insights into filovirus entry...
  7. pmc Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
    John M Dye
    Division of Virology, US Army Medical Research Institute for Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 109:5034-9. 2012
    ....
  8. ncbi LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
    Thomas Gramberg
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
    Virology 340:224-36. 2005
    ..In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes...
  9. pmc Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections
    Dana L Swenson
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Vaccine Immunol 15:460-7. 2008
    ..This study indicates the feasibility of vaccination against all current filovirus threats in the event of natural hemorrhagic fever outbreak or biological attack...
  10. ncbi Outbreaks of filovirus hemorrhagic fever: time to refocus on the patient
    Daniel G Bausch
    Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    J Infect Dis 196:S136-41. 2007
    ..A summary of the opportunities for and challenges to improving treatment of filovirus hemorrhagic fevers is presented here...
  11. pmc Association of the caveola vesicular system with cellular entry by filoviruses
    Cyril J Empig
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141 9100, USA
    J Virol 76:5266-70. 2002
    ..Collectively, these results provide evidence suggesting that filoviruses use caveolae to gain entry into cells...
  12. pmc Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha
    Patrick L Sinn
    Program in Gene Therapy, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 77:5902-10. 2003
    ..Understanding viral vector binding and entry pathways is fundamental for developing cystic fibrosis gene therapy applications...
  13. pmc Ebola virus VP40-induced particle formation and association with the lipid bilayer
    L D Jasenosky
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 75:5205-14. 2001
    ..These data suggest that VP40 binds the lipid bilayer in an efficient yet structurally complex fashion...
  14. pmc Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses
    Haitao Guo
    Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, USA
    Antimicrob Agents Chemother 55:478-86. 2011
    ..The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed...
  15. pmc Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses
    Thomas Hoenen
    Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA Department of Virology, Philipps University Marburg, Marburg, Germany
    Antiviral Res 91:195-208. 2011
    ....
  16. pmc Advances in virus-like particle vaccines for filoviruses
    Kelly L Warfield
    Vaccine Development, Integrated BioTherapeutics, 21 Firstfield Rd, Ste 100, Gaithersburg, MD 20878, USA
    J Infect Dis 204:S1053-9. 2011
    ..This review will discuss published work to date regarding development of the VLP vaccines for prevention of lethal filovirus hemorrhagic fever...
  17. ncbi Filovirus hemorrhagic fever outbreak case management: a review of current and future treatment options
    Paul Roddy
    Médecins Sans Frontières Spain, Barcelona, Spain
    J Infect Dis 204:S791-5. 2011
    ..Our outlined summary may assist future FHF outbreak case management teams to create collaborative platforms and develop relevant treatment protocols aimed at improving clinical outcome...
  18. pmc Correlates of immunity to filovirus infection
    Steven B Bradfute
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, MD 21702, USA
    Viruses 3:982-1000. 2011
    ..It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment...
  19. pmc Electron tomography reveals the steps in filovirus budding
    Sonja Welsch
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Pathog 6:e1000875. 2010
    ..We propose that this represents a general sequence of events also followed by other filamentous and rod-shaped viruses...
  20. ncbi Filoviruses: Interactions with the host cell
    O Dolnik
    Philipps Universitat Marburg, Institut fur Virologie, Marburg, Germany
    Cell Mol Life Sci 65:756-76. 2008
    ..This review describes advances in understanding the interactions between host cells and filoviruses during viral attachment, entry, transcription, assembly and budding...
  21. pmc Antiviral activity of a small-molecule inhibitor of filovirus infection
    Travis K Warren
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    Antimicrob Agents Chemother 54:2152-9. 2010
    ..Taken together, these results identify a promising antiviral therapeutic candidate for the treatment of filovirus infections...
  22. ncbi Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein
    H Feldmann
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
    Virology 199:469-73. 1994
    ..These data, together with prior findings, indicate that the genus Filovirus can be divided into a MBG group and EBO group...
  23. ncbi Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    J Infect Dis 196:S421-9. 2007
    ..The goal of this work was to increase the yield of VLPs, while retaining their immunogenic properties...
  24. pmc Filovirus entry into cells - new insights
    Emily Happy Miller
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, United States
    Curr Opin Virol 2:206-14. 2012
    ..Membrane fusion delivers the viral nucleocapsid core into the cytoplasm, which is the site of filovirus replication. This review summarizes our understanding of the filovirus entry mechanism, with emphasis on recent findings...
  25. ncbi Current perspectives on the phylogeny of Filoviridae
    Roger W Barrette
    Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, USA
    Infect Genet Evol 11:1514-9. 2011
    ..Bundibugyo ebolavirus; the recent discovery of Lloviu virus as a potential new genus, Cuevavirus, within Filoviridae; and germline integrations of filovirus-like sequences in some animal species bring new insights into the ..
  26. ncbi Viral haemorrhagic fever and vascular alterations
    P Aleksandrowicz
    Institut fur Physiologie, Technische Universitat, Medizinische Fakultat, Fetcherstrasse 74, 01307 Dresden, Germany
    Hamostaseologie 28:77-84. 2008
    ....
  27. ncbi Filoviruses: recent advances and future challenges
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Manitoba, Canada
    J Infect Dis 196:S129-30. 2007
  28. ncbi Filovirus assembly and budding
    Bettina Hartlieb
    Institut fur Virologie, Robert Koch str 17, 35037 Marburg, Germany
    Virology 344:64-70. 2006
    ..As a consequence, assembly and budding steps are defined to specific cellular compartments, and the recent progress in understanding how the different components are assembled into stable enveloped virus particles is reviewed...
  29. pmc Potential mammalian filovirus reservoirs
    A Townsend Peterson
    University of Kansas, Lawrence, Kansas 66045, USA
    Emerg Infect Dis 10:2073-81. 2004
    ..Studying the remainder of these taxa may be a fruitful avenue for pursuing the identity of natural reservoirs of filoviruses...
  30. ncbi High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settings
    Jonathan S Towner
    Special Pathogens Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S205-12. 2007
    ..Furthermore, the applicability of this method to an outbreak setting was demonstrated by correct analysis of >500 specimens at a field laboratory established during a recent outbreak of Marburg hemorrhagic fever in Angola...
  31. ncbi Status and challenges of filovirus vaccines
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 25:1923-34. 2007
    ..Nevertheless, nonhuman primate studies have shown that protection against Marburg and Ebola is possible and there is hope that one day a vaccine will be licensed for human use...
  32. ncbi The role of the Type I interferon response in the resistance of mice to filovirus infection
    M Bray
    Department of Viral Therapeutics, Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    J Gen Virol 82:1365-73. 2001
    ..The outcome of filovirus transfer between animal species appears to be determined by interactions between the virus and the innate immune response...
  33. ncbi Filovirus-like particles as vaccines and discovery tools
    Kelly L Warfield
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Vaccines 4:429-40. 2005
    Ebola and Marburg viruses are members of the family Filoviridae, which cause severe hemorrhagic fevers in humans. Filovirus outbreaks have been sporadic, with mortality rates currently ranging from 30 to 90%...
  34. ncbi Potential factors induced by filoviruses that lead to immune supression
    Mansour Mohamadzadeh
    Northwestern University, School of Medicine, Chicago, IL 60611, USA
    Curr Mol Med 9:174-85. 2009
    ..Thus, in light of accumulating scientific observations, the challenge is now to characterize the molecular mechanisms that may result in rational strategies leading to new therapeutics and vaccines...
  35. ncbi NKp30-dependent cytolysis of filovirus-infected human dendritic cells
    Claudette L Fuller
    United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Cell Microbiol 9:962-76. 2007
    ..Further elucidation of the biology of NK cell activation, specifically natural cytotoxicity receptors like NKp30 and NKp46, promises to aid our understanding of microbial pathology...
  36. pmc "Filoviruses": a real pandemic threat?
    Byron E E Martina
    Erasmus MC, Department of Virology, Rotterdam, The Netherlands
    EMBO Mol Med 1:10-8. 2009
    ....
  37. ncbi Ebolavirus and other filoviruses
    J P Gonzalez
    Fundamentals and Domains of Disease Emergence Research Unit, RU178, Institute for Research Development, IRD, Paris, France
    Curr Top Microbiol Immunol 315:363-87. 2007
    ..During the reproductive period, infected body fluid can also be shed in the environment and present a potential risk for indirect transmission to other vertebrates...
  38. ncbi The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
    ..Here we review the existing reverse genetics systems for VHF causing viruses and discuss their use in studying viral replication, pathogenesis, and the development of antivirals and vaccines...
  39. ncbi [Filovirus infection: pathogenesis and host specificity]
    Ayato Takada
    Tanpakushitsu Kakusan Koso 52:1242-7. 2007
  40. ncbi [The use of monoclonal antibodies in studying the causative agents of viral hemorrhagic fevers]
    G V Borisevich
    Vopr Virusol 48:4-8. 2003
    ..The methodological specificity of obtaining the Mabs to viral hemorrhagic-fevers' agents as well as data on its practical use are discussed...
  41. ncbi Characterization of the L gene and 5' trailer region of Ebola virus
    V E Volchkov
    Institut fur Virologie, Philipps Universitat, Marburg, Germany
    J Gen Virol 80:355-62. 1999
    ..The presence of several conserved linear domains commonly found within L proteins of other members of the order Mononegavirales identified this protein as the RNA-dependent RNA polymerase of Ebola virus...
  42. ncbi In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 196:S382-9. 2007
    ..Therefore, we explored the application of minigenomes as screening tools to identify functional siRNA targets under biosafety level 2 conditions...
  43. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  44. ncbi A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-derived zinc-chelating trioxa-adamantane-triol
    Andreas J Kesel
    Chammünsterstr 47, D 81827 München, Germany
    Bioorg Med Chem 11:4599-613. 2003
    ..rabies virus), Paramyxoviridae (human parainfluenza virus, measles virus, human respiratory syncytial virus), Filoviridae (Marburg virus, Ebola virus), Bornaviridae (Borna disease virus), Bunyaviridae (Hantaan virus), Arenaviridae (..
  45. ncbi Paramyxovirus mRNA editing, the "rule of six" and error catastrophe: a hypothesis
    Daniel Kolakofsky
    Department of Microbiology and Molecular Medicine, Universite de Geneve, Geneva, Switzerland
    J Gen Virol 86:1869-77. 2005
    ..Paramyxoviridae, composed of two subfamilies, the Paramyxovirinae and Pneumovirinae, the Rhabdoviridae and the Filoviridae. These viruses, also called non-segmented negative-strand RNA viruses (NNV), contain five to ten tandemly ..
  46. ncbi Identification and partial characterization of Taastrup virus: a newly identified member species of the Mononegavirales
    J O Bock
    Department of Clinical Microbiology, Rigshospitalet, DK 2100 Copenhagen East, Denmark
    Virology 319:49-59. 2004
    ..both potential O-linked (14) and N-linked (9) glycosylation sites-a feature shared with the glycoproteins of Filoviridae and Pneumovirinae, and a nucleoprotein (N) with homology to the nucleoprotein of viral hemorrhagic septicemia ..
  47. ncbi Viral hemorrhagic fevers
    Aileen M Marty
    Battelle Memorial Institute, Suite 601, 1550 Crystal Drive, Arlington, VA 22202 4172, USA
    Clin Lab Med 26:345-86, viii. 2006
    ..of single-stranded ribonucleic acid(ssRNA) viruses from four diverse viral families Arenaviridae,Bunyaviridae, Filoviridae, and Flaviviridae cause an acute systemic febrile syndrome called viral hemorrhagic fever (VHF)...
  48. pmc Genomic organization of Borna disease virus
    T Briese
    Department of Neurology, University of California, Irvine 92717
    Proc Natl Acad Sci U S A 91:4362-6. 1994
    ..Homology to Filoviridae, Paramyxoviridae, and Rhabdoviridae is found in both cistronic and extracistronic regions...
  49. pmc The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses
    Margaret R Macdonald
    Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Avenue, New York, NY 10065, USA
    J Virol 81:13509-18. 2007
    ..zinc finger antiviral protein (ZAP) imparts a cellular antiviral state against Retroviridae, Togaviridae, and Filoviridae virus family members...
  50. ncbi Antibodies to haemorrhagic fever viruses in Madagascar populations
    C C Mathiot
    Institut Pasteur, Bangui, Central African Republic
    Trans R Soc Trop Med Hyg 83:407-9. 1989
    ..fever and Rift Valley fever viruses (Bunyaviridae), Ebola (strains Zaire and Sudan) and Marburg viruses (Filoviridae), and Lassa virus (Arenaviridae). The highest prevalence rate was that of Ebola virus (4.5%)...
  51. ncbi Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle
    H Feldmann
    Institut fuer Virologie, Philipps Universitaet, Marburg, F R G
    Virus Res 24:1-19. 1992
    ..The data support the concept of a common taxonomic order Mononegavirales comprising the Filoviridae, Paramyxoviridae, and Rhabdoviridae families.
  52. ncbi Structural basis for membrane fusion by enveloped viruses
    W Weissenhorn
    Laboratory of Molecular Medicine, Children s Hospital, Boston, MA 02215, USA
    Mol Membr Biol 16:3-9. 1999
    ..fusion proteins from diverse families such as Retroviridae (HIV-1), Orthomyxoviridae (influenza virus), and Filoviridae (Ebola virus)...
  53. pmc Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses
    Mansour Mohamadzadeh
    U S Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA
    J Virol 80:7235-44. 2006
    Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates...
  54. ncbi [Ebola virus: what the practitioner needs to know]
    A J Georges
    Unité de Biologie des Rétrovirus et Pathogènes Viraux Spéciaux, Centre International de Recherche Médicale de Franceville CIRMF, Franceville, Gabon
    Med Trop (Mars) 58:177-86. 1998
    The Ebola virus is an RNA virus of Filoviridae family. The earliest documented fatal epidemic of Ebola hemorrhagic occurred in 1976. There are four genetically different subtypes of Ebola virus...
  55. ncbi Reverse genetics of mononegavirales
    K K Conzelmann
    Max von Pettenkofer Institut and Genzentrum, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Curr Top Microbiol Immunol 283:1-41. 2004
    ..1994, reverse genetics systems have been established for members of most genera of the Rhabdo-, Paramyxo-, and Filoviridae families...
  56. pmc Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems
    E Muhlberger
    Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
    J Virol 73:2333-42. 1999
    The members of the family Filoviridae, Marburg virus (MBGV) and Ebola virus (EBOV), are very similar in terms of morphology, genome organization, and protein composition...
  57. ncbi Protection against filovirus infection: virus-like particle vaccines
    Chinglai Yang
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Expert Rev Vaccines 7:333-44. 2008
    ..progress has been made in vaccine development against infection by Ebola and Marburg viruses, members of the Filoviridae, which cause severe hemorrhagic fevers in humans with no effective treatment and a mortality rate of up to 90%...
  58. pmc Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice
    Krishnamurthy Konduru
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 29:2968-77. 2011
    Ebola virus is a Filoviridae that causes hemorrhagic fever in humans and induces high morbidity and mortality rates...
  59. pmc Shedding light on filovirus infection with high-content imaging
    Gianluca Pegoraro
    United States Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702, USA
    Viruses 4:1354-71. 2012
    ..Finally, we discuss possible novel applications of HCI in the context of filovirus research with particular emphasis on the identification of possible cellular biomarkers of virus infection...
  60. ncbi Serological reactivity of baculovirus-expressed Ebola virus VP35 and nucleoproteins
    Jan Groen
    Institute of Virology, Erasmus MC, Dr Molenwaterplein 40, 3015GD, Rotterdam, The Netherlands
    Microbes Infect 5:379-85. 2003
    Ebola virus (EBOV) is a member of the family Filoviridae and is classified as a biosafety level 4 virus. This classification makes the preparation of antigen and performance of diagnostic assays time-consuming and complicated...
  61. pmc Evaluation of perceived threat differences posed by filovirus variants
    Jens H Kuhn
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research, Integrated Research Facility at Fort Detrick, Frederick, Maryland, USA
    Biosecur Bioterror 9:361-71. 2011
    ....
  62. ncbi Viral hemorrhagic fever-induced acute kidney injury
    Emerson Q Lima
    Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Sao Paulo, Brazil
    Semin Nephrol 28:409-15. 2008
    ..are diseases caused by the RNA virus from 4 different families (Flaviridiae, Arenaviridae, Bunyaviridae, and Filoviridae) that are acquired through the bite of an infected arthropod or by the inhalation of particles of rodent ..
  63. pmc Long-term survival of an urban fruit bat seropositive for Ebola and Lagos bat viruses
    David T S Hayman
    Cambridge Infectious Diseases Consortium, University of Cambridge, Cambridge, UK
    PLoS ONE 5:e11978. 2010
    Ebolaviruses (EBOV) (family Filoviridae) cause viral hemorrhagic fevers in humans and non-human primates when they spill over from their wildlife reservoir hosts with case fatality rates of up to 90%...
  64. ncbi Hemorrhagic fever virus-induced changes in hemostasis and vascular biology
    J P Chen
    Department of Medical Biology, University of Tennessee Graduate School of Medicine, Knoxville, USA
    Blood Coagul Fibrinolysis 11:461-83. 2000
    ..There are 14 HF viruses, which belong to four viral families: Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae...
  65. pmc The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil
    W Weissenhorn
    Laboratory of Molecular Medicine, Howard Hughes Medical Institute, The Children s Hospital, 320 Longwood Avenue Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 95:6032-6. 1998
    ..further evidence that viral fusion proteins from diverse families such as Orthomyxoviridae (Influenza), Retroviridae (HIV-1), and Filoviridae (Ebola) share common structural features, and suggesting a common membrane fusion mechanism.
  66. pmc Detection of all known filovirus species by reverse transcription-polymerase chain reaction using a primer set specific for the viral nucleoprotein gene
    Hirohito Ogawa
    Hokudai Center for Zoonosis Control in Zambia, School of Veterinary Medicine, The University of Zambia, Lusaka, Zambia
    J Virol Methods 171:310-3. 2011
    ..This assay will be a useful method for diagnostics and epidemiological studies of filovirus infections...
  67. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
    Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa...
  68. ncbi Ebola and Marburg viruses: pathogenesis and development of countermeasures
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Curr Mol Med 5:761-72. 2005
    Ebola and Marburg viruses, family Filoviridae, are among the best known examples of emerging and re-emerging pathogens...
  69. pmc Mapping of conserved and species-specific antibody epitopes on the Ebola virus nucleoprotein
    Katendi Changula
    School of Veterinary Medicine, The University of Zambia, Great East Road Campus, Lusaka, Zambia
    Virus Res 176:83-90. 2013
    Filoviruses (viruses in the genus Ebolavirus and Marburgvirus in the family Filoviridae) cause severe haemorrhagic fever in humans and nonhuman primates...
  70. ncbi Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
    Travis K Warren
    Division of Molecular and Translational Sciences, Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, Maryland 21702, USA
    Nature 508:402-5. 2014
    ..We provide additional pharmacological characterizations supporting the potential development of BCX4430 as a countermeasure against human filovirus diseases and other viral diseases representing major public health threats. ..
  71. ncbi The Ebola Virus Matrix Protein VP40 Selectively Induces Vesiculation from Phosphatidylserine-enriched Membranes
    Smita P Soni
    From the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, Indiana 46617 and
    J Biol Chem 289:33590-7. 2014
    Ebola virus is from the Filoviridae family of viruses and is one of the most virulent pathogens known with ∼60% clinical fatality...
  72. pmc Inhibition of heat-shock protein 90 reduces Ebola virus replication
    Darci R Smith
    U S Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD, United States
    Antiviral Res 87:187-94. 2010
    Ebola virus (EBOV), a negative-sense RNA virus in the family Filoviridae, is known to cause severe hemorrhagic fever in humans and other primates...
  73. pmc RNA polymerase I-driven minigenome system for Ebola viruses
    Allison Groseth
    National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    J Virol 79:4425-33. 2005
    ..However, despite substantial sequence homology to other members of the family Filoviridae, Reston ebolavirus displays reduced pathogenicity for nonhuman primates and has never been demonstrated to ..
  74. ncbi Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis
    M Goeijenbier
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Neth J Med 72:442-8. 2014
    ..EBOV), belongs to the genus Ebolavirus which together with the genus Marburgvirus forms the family of the Filoviridae. EBOV is one of the most virulent pathogens among the viral haemorrhagic fevers, and case fatality rates up to ..
  75. ncbi Ebolavirus and Marburgvirus: insight the Filoviridae family
    Paolo Ascenzi
    National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, Via Portuense 292, I 00149 Roma, Italy
    Mol Aspects Med 29:151-85. 2008
    Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins...
  76. pmc Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 159:1229-37. 2014
    ..EBOV" would suffice if only one EBOV strain/variant/isolate is addressed. ..
  77. ncbi [Bats and other reservoir hosts of Filoviridae. Danger of epidemic on the African continent?--a deductive literature analysis]
    Felix Laminger
    Abteilung für Allgemein und Familienmedizin am Zentrum für Public Health, Unit Ethnomedizin und International Health der Medizinischen Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 122:19-30. 2010
    Ebola and Marburg virus, forming the Filoviridae family, cause hemorrhagic fever in countries of sub-Saharan Africa. These viral diseases are characterized by a sudden epidemic occurrence as well as a high lethality...
  78. pmc The role of platelets in the pathogenesis of viral hemorrhagic fevers
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 8:e2858. 2014
    ..induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all ..
  79. pmc Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus
    James L Murray
    National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:11742-51. 2005
    ..These results suggest that Rab9 is an important cellular target for inhibiting diverse viruses and help to define a late-endosome-to-plasma-membrane vesicular transport pathway important in viral assembly...
  80. pmc Ebolavirus VP35 is a multifunctional virulence factor
    Daisy W Leung
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA
    Virulence 1:526-31. 2010
    Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available...
  81. ncbi Filovirus entry
    Graham Simmons
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    Adv Exp Med Biol 790:83-94. 2013
    ..In particular, host cell factors such as endosomal proteases and the intracellular receptor Niemann-Pick C1 are now known to play a vital role in activating the membrane fusion potential of filovirus glycoproteins. ..
  82. pmc Tick-borne Nyamanini virus replicates in the nucleus and exhibits unusual genome and matrix protein properties
    Marieke Herrel
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 86:10739-47. 2012
    ..two distinct proteins serve a matrix protein function in NYMV as previously described for members of the family Filoviridae. We further found that NYMV replicates in the nucleus of infected cells like members of the family Bornaviridae...
  83. ncbi Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Clin Microbiol Infect 17:964-76. 2011
    Ebola and Marburg viruses are the only members of the Filoviridae family (order Mononegavirales), a group of viruses characterized by a linear, non-segmented, single-strand negative RNA genome...
  84. ncbi [Ebola and Marburg fever--outbreaks of viral haemorrhagic fever]
    R Chlibek
    Katedra epidemiologie Fakulty vojenského zdravotnictví Univerzity obrany, Hradec Kralove
    Klin Mikrobiol Infekc Lek 12:217-23. 2006
    ..Ebola fever and Marburg fever, whose agents come from the same group of Filoviridae family, belong among these diseases...
  85. pmc A review of filovirus work and facilities at the Defence Science and Technology Laboratory Porton Down
    Sophie J Smither
    Biomedical Sciences Department, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Viruses 4:1305-17. 2012
    ..Fundamental research directed to the study and understanding of the infectious and pathogenic nature of the filoviruses, particularly in aerosols, will be reported...
  86. ncbi How do filovirus filaments bend without breaking?
    Tim F Booth
    National Microbiology Laboratory, Winnipeg, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada Electronic address
    Trends Microbiol 21:583-93. 2013
    ..We review how the structure of filoviruses and paramyxoviruses permits this morphological flexibility in comparison to rhabdoviruses that have short, bullet-shaped virions with relatively rigid envelopes. ..
  87. pmc Rapid molecular strategy for filovirus detection and characterization
    Junhui Zhai
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Clin Microbiol 45:224-6. 2007
    ..Phylogenetic assignment is achieved by automated web-based sequence analysis of amplification products...
  88. pmc Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage
    Paul W Fenimore
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS ONE 7:e44769. 2012
    ..We demonstrate in vivo immunogenicity and protection against a heterologous challenge in a mouse model. This design work delineates the likely requirements and limitations on broadly-protective filoviral CTL vaccines...
  89. ncbi [Laboratory diagnosis of viral hemorrhagic fevers]
    Zheng Pang
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
    Bing Du Xue Bao 29:349-56. 2013
    ..that are caused by four distinct families of RNA viruses belonging to the families Bunyaviridae, Flaviviridae, Filoviridae and Arenaviridae, the main clinical symptoms of these diseases are accompanied by fever and bleeding...
  90. pmc High-throughput virtual screening and docking studies of matrix protein vp40 of ebola virus
    Thangaraju Tamilvanan
    Department of Bioinformatics, School of Bioengineering, Faculty of Engineering and Technology, SRM University, Kattankulathur, 603203, Tamil Nadu, India
    Bioinformation 9:286-92. 2013
    Ebolavirus, a member of the Filoviridae family of negative-sense RNA viruses, causes severe haemorrhagic fever leading up to 90% lethality. Ebolavirus matrix protein VP40 is involved in the virus assembly and budding process...
  91. pmc Novel mutations in Marburg virus glycoprotein associated with viral evasion from antibody mediated immune pressure
    Masahiro Kajihara
    Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001 0020, Japan
    J Gen Virol 94:876-83. 2013
    Marburg virus (MARV) and Ebola virus, members of the family Filoviridae, cause lethal haemorrhagic fever in humans and non-human primates...
  92. ncbi Characterization of a putative filovirus vaccine: virus-like particles
    Karen A O Martins
    US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702, USA
    Virol Sin 28:65-70. 2013
    ..In this review, we will highlight the development of the filovirus VLP and describe the current understanding of VLP immunogenicity and correlates of protection...
  93. ncbi [Viral hemorrhagic fevers as a biological weapon]
    Sambor Grygorczuk
    Klinika Chorób Zakaźnych i Neuroinfekcji Akademii Medycznej w Białymstoku
    Pol Merkur Lekarski 14:146-9. 2003
    ..The knowledge of the biology and epidemiology of Filoviridae is still limited, which makes the results of bioterrorist attack using these pathogens hard to predict.
  94. pmc Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor
    Anuja Krishnan
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Viruses 4:2471-84. 2012
    ....
  95. ncbi Research on prevention and treatment of hemorrhagic fevers
    Justyna Joniec
    Biological Threats Identification and Countermeasure Centre, Military Institute of Hygiene and Epidemiology, Puławy, Poland
    Ann Agric Environ Med 19:165-71. 2012
    ..are severe zoonotic diseases caused by RNA-viruses classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae...
  96. pmc Evolutionary maintenance of filovirus-like genes in bat genomes
    Derek J Taylor
    Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260, USA
    BMC Evol Biol 11:336. 2011
    ..We also estimated the age of filovirus VP35-like gene integrations and tested the phylogenetic hypotheses that there is a eutherian mammal clade and a marsupial/ebolavirus/Marburgvirus dichotomy for filoviruses...
  97. ncbi Lethality and pathogenesis of airborne infection with filoviruses in A129 α/β -/- interferon receptor-deficient mice
    Mark S Lever
    Defence Science and Technology Laboratories Dstl, Porton Down, Salisbury, Wiltshire, UK
    J Med Microbiol 61:8-15. 2012
    ..The KO mouse may provide a useful model to test potential antiviral therapeutics against wild-type filoviruses...
  98. ncbi Novel roles for TIM-1 in immunity and infection
    Paul D Rennert
    Department of Molecular Discovery and Immunobiology, Biogen Idec Inc, Cambridge, MA 02142, United States
    Immunol Lett 141:28-35. 2011
    ..Of considerable interest are the novel findings that TIM-1 mediates virus entry and virulence...
  99. pmc Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity
    Sophiya Karki
    Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 7:e37398. 2012
    The zinc finger antiviral protein (ZAP) is a host factor that mediates inhibition of viruses in the Filoviridae, Retroviridae and Togaviridae families...
  100. ncbi [Ebola and Marburg hemorrhagic fever viruses: update on filoviruses]
    E Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Med Trop (Mars) 71:111-21. 2011
    The Ebola and Marburg viruses are the sole members of the Filoviridae family of viruses. They are characterized by a long filamentous form that is unique in the viral world...
  101. ncbi Filovirus-like particles detected in the leafhopper Psammotettix alienus
    T Lundsgaard
    Department of Plant Biology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Virus Res 48:35-40. 1997
    ..The particles described in this paper resemble virions in the virus family Filoviridae, but can be distinguished by having a smaller particle diameter...

Research Grants24

  1. Bioavailable proteasome inhibitors as broad-spectrum antivirals
    ALEXANDER NICLAS FREIBERG; Fiscal Year: 2013
    ..vitro preliminary data showing that Bortezomib can inhibit the replication of multiple Category A-C pathogens: Filoviridae (Ebola), Paramyxoviridae (Nipah), Bunyaviridae (Rift Valley fever), Flaviviridae (Russian-Spring-Summer ..
  2. Lipid-Protein Interactions in Viral Assembly and Virus Like Particle Formation
    ROBERT VIRGIL STAHELIN; Fiscal Year: 2012
    ..objective of this proposed research is to fully elucidate the mechanistic basis of lipid-interactions by filoviridae matrix proteins and their mechanism of generating VLPs from host cells...
  3. Upregulation of ZAP expression as a novel approach for anti-alphavirus therapy
    Margaret R Macdonald; Fiscal Year: 2013
    ..inhibition of alphaviruses, including the prototype Sindbis virus, as well as viruses in the Retroviridae and Filoviridae families...
  4. Screening and development of anti-Ebola entry inhibitors
    Lijun Rong; Fiscal Year: 2010
    Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of 4-14 days...
  5. Development of antivirals for newly emerging pathogens Ebola and Marburg.
    Matteo Porotto; Fiscal Year: 2013
    ..Ebola viruses (EBOV) and Marburg virus (MARV) are two genera of enveloped viruses that constitute the family of Filoviridae. They are among the most lethal human pathogens, causing a severe hemorrhagic fever with mortality rates up to ..
  6. Genome wide siRNA screen for identifying host factors required for ZAP function
    Margaret R Macdonald; Fiscal Year: 2013
    ..that demonstrates potent inhibition of viruses in this genus, as well as viruses in the Retroviridae and Filoviridae families...
  7. rVSV Vectored Vaccine to Protect Against Ebola and Marburg Viruses
    THOMAS WILLIAM GEISBERT; Fiscal Year: 2013
    ..enveloped non-segmented negative sense RNA viruses representing the two genera that comprise the family Filoviridae. These viruses are important human pathogens with case fatality rates ranging from 55% to 90% for EboV and up ..
  8. ANTIVIRAL DRUG DELIVERY WITH LYOPHILIZED PLATELETS
    Thomas Fischer; Fiscal Year: 2004
    ..Viruses of the Arenaviridea (e.g., Lassa fever virus), Filoviridae (e.g., Ebola and Marburg viruses), Bunyaviridae (e.g., Rift Valley virus) and Flaviviridae (e.g...
  9. Antiviral Drugs Against Hemorrhagic Fever Viruses
    Dennis Hruby; Fiscal Year: 2003
    ..HFVs), in particular Lassa fever (Arenaviridae), Rift Valley fever (Bunyaviridae), and Ebola and Marburg (Filoviridae) viruses are potential biological weapons agents due to their ease of dissemination, person-to-person ..
  10. Initiation of Nucleocapsid Assembly in Ebola virus
    SHARON CRARY; Fiscal Year: 2004
    ..Ebola virus is classified in the family Filoviridae. It consists of a single, approximately 19-kilobase strand of negative-sense RNA that is tightly wrapped in ..
  11. Gene Expression Profiling in Filovirus-Infected Cells
    Michael Katze; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Members of the filoviridae family of RNA viruses are causative agents of viral hemorrhagic fever and represent some of the most deadly human pathogens...
  12. Disruption of Conserved RNA Stem-Loops in Filovirus RNA
    CASEY MORROW; Fiscal Year: 2003
    The family Filoviridae consists of the Ebola and Marburg viruses...
  13. Elucidating the Entry Mechanism of Ebola Viruses
    Lijun Rong; Fiscal Year: 2009
    Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction...
  14. COMMON FEATURES OF REV LIKE VIRAL REGULATORY PROTIENS
    Thomas Hope; Fiscal Year: 2001
    ..This basic knowledge may lay the groundwork for novel therapeutic approaches targeting Rev function. ..
  15. Cell Biology of Filovirus Entry
    Thomas Hope; Fiscal Year: 2004
    ..Direct visualization of these viruses will provide important new insights into how these agents bind to and enter target cells. ..
  16. Development of tissue explant models for microbicide evaluation
    Thomas Hope; Fiscal Year: 2007
    ..It is hoped that preventing HIV infection will decrease the number of people in the world infected with HIV and slow the AIDS epidemic. ..
  17. Analysis of the Ebola Virus VP24 Channel Protein
    RONALD HARTY; Fiscal Year: 2003
    ..Overall this application will address key mechanisms of Ebola virus pathogenesis that may lead to the development of novel paradigms with direct impact on the development of therapeutic approaches. ..
  18. Ebola Virus VP40-Host Interactions In VIvo
    RONALD HARTY; Fiscal Year: 2005
    ..These studies will be fundamental for our understanding of Ebola virus budding and necessary for the successful development of future therapeutic approaches. ..
  19. Budding of Negative-sense RNA Viruses
    RONALD HARTY; Fiscal Year: 2006
    ....
  20. Identification of new targets for alphavirus inhibition
    Margaret MacDonald; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. Novel DNA/VLP Vaccines Against Influenza
    Chinglai Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Studies on ZAP, a broad-spectrum alphavirus inhibitor
    Margaret MacDonald; Fiscal Year: 2009
    ..Understanding the mechanism of ZAP's inhibition of alphavirus replication may lead to the development of new therapeutic or preventative agents for illness due to alphavirus infection. ..
  23. Host factors in the alphavirus replication complex
    Margaret MacDonald; Fiscal Year: 2009
    ..Understanding the components of and molecular interactions within the Alphavirus minus and plus strand replicases will facilitate future exploration for inhibitors of these important pathogens. ..
  24. Packaging of Ebola Virus RNA into Budding VLPs
    RONALD HARTY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..