Genomes and Genes
Summary: A family of RNA viruses, many of which cause disease in humans and domestic animals. There are three genera FLAVIVIRUS; PESTIVIRUS; and HEPACIVIRUS, as well as several unassigned species.
Publications216 found, 100 shown here
- Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hostsFrancisco P Lobo
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
PLoS ONE 4:e6282. 2009..b>Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or invertebrate ..
- The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family FlaviviridaeJack T Stapleton
Department of Internal Medicine, Veterans Administration Medical Center and the University of Iowa, Iowa City, IA, USA
J Gen Virol 92:233-46. 2011..B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the ..
- Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorV Agnello
Lahey Clinic Medical Center, Department of Laboratory Medicine, Burlington, MA 01805, USA
Proc Natl Acad Sci U S A 96:12766-71. 1999Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by low density lipoprotein (LDL) receptors on cultured cells by several lines of ..
- Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in BangladeshJonathan H Epstein
Conservation Medicine Program, Wildlife Trust, New York, New York, United States of America
PLoS Pathog 6:e1000972. 2010..Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.
- Taxonomy of the virus family FlaviviridaeCharles H Calisher
Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Adv Virus Res 59:1-19. 2003
- Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesisC T Ranjith-Kumar
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
J Virol 75:8615-23. 2001....
- Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteinsA S Belyaev
Genelabs Technologies, Inc, Redwood City, California 94063, USA
J Virol 72:868-72. 1998..NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu1561, and Ala1598...
- Defective adenoviruses as novel vaccines for the FlaviviridaeJ Stephenson
London School of Hygiene and Tropical Medicine, Division of Infectious and Tropical Medicine, UK
Clin Diagn Virol 10:187-94. 1998..Other diseases such as dengue fever (DF) and hepatitis C are still major public health problems as no licensed vaccines are in use...
- Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agentJ Linnen
Genelabs Technologies, Redwood City, CA 94063, USA
Science 271:505-8. 1996..Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States...
- G protein-coupled receptor kinase 2 promotes flaviviridae entry and replicationCaroline Le Sommer
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS Negl Trop Dis 6:e1820. 2012..propagation of DENV and Hepatitis C virus (HCV) indicating that GRK2 requirement is conserved throughout the Flaviviridae. Finally, we found that GRK2 participates in multiple distinct steps of the flavivirus life cycle by promoting ..
- Dynamics of GB virus C viremia early after orthotopic liver transplantation indicates extrahepatic tissues as the predominant site of GB virus C replicationT Berg
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Berlin
Hepatology 29:245-9. 1999..However, one cannot exclude that host or viral factors exist that predispose GBV-C replication predominantly in the liver...
- A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South AfricaM A Sathar
Department of Medicine, University of Natal King Edward VIII Hospital, South Africa
Virus Res 64:151-60. 1999..None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates...
- Biophysical characterization of GB virus C from human plasmaS L Melvin
Virus Discovery Group, Experimental Biology Research, Abbott Diagnostic Division, Abbott Laboratories, North Chicago, IL 60064, USA
J Virol Methods 71:147-57. 1998..The treated material was non-filterable and the RNA had a density of > 1.5 gm/ml...
- Species-specific variants of GB virus A in captive monkeys T P Leary
Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, Illinois 60064, USA
J Virol 70:9028-30. 1996..Though sequences of isolates from each animal species are virtually identical at the nucleotide level (95%), isolates from different species are dramatically different (52 to 79% identical) and genetically cluster on this basis...
- Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesisCatherine L Murray
The Rockefeller University, New York, NY 10065, USA
Nat Rev Microbiol 6:699-708. 2008Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide...
- Expression of the GB virus C E2 glycoprotein using the Semliki Forest virus vector system and its utility as a serologic markerT J Pilot-Matias
Virus Discovery Group, Diagnostics Division, Abbott Laboratories, North Chicago, Illinois 60064, USA
Virology 225:282-92. 1996..Thus, this system provided a rapid means to identify GBV-C E2 as a useful antigen for the study of GBV-C exposure...
- Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virusT J Tucker
Department of Medical Microbiology SAIMR, University of Cape Town, Observatory, Cape Town, South Africa
J Med Virol 61:52-8. 2000..This preliminary study concludes that GBV-C/HGV is a lymphotropic virus that replicates primarily in the spleen and bone marrow...
- Phylogenetic analysis of GBV-C/hepatitis G virusD B Smith
Department of Medical Microbiology, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
J Gen Virol 81:769-80. 2000..The geographical distribution of virus variants is consistent with a long evolutionary history that may parallel that of pre-historic human migrations, implying that the long-term evolution of this RNA virus is extremely slow...
- Conserved RNA secondary structures in Flaviviridae genomesCaroline Thurner
Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universitat Wien, Wahringerstrasse 17, A 1090 Wien, Austria
J Gen Virol 85:1113-24. 2004..computational survey of evolutionarily conserved secondary structure motifs in the genomic RNAs of the family Flaviviridae: This virus family consists of the three genera Flavivirus, Pestivirus and Hepacivirus and the group of GB ..
- Generation of infectious and transmissible virions from a GB virus B full-length consensus clone in tamarinsA Sbardellati
Istituto di Ricerche di Biologia Molecolare P. Angeletti (IRBM, Via Pontina Km 30.600, 00040 Pomezia (Roma, Italy
J Gen Virol 82:2437-48. 2001..Host humoral immune response to GBV-B antigens was also monitored. The progression of the disease was compared to that induced by intravenous injection of different amounts of the non-recombinant virus...
- RNA-dependent RNA polymerases from FlaviviridaeKyung H Choi
Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch at Galveston, TX 77555 0647, USA
Curr Opin Struct Biol 19:746-51. 2009Viral genome replication in Flaviviridae is carried out by a virally encoded RNA-dependent RNA polymerase (RdRp)...
- The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteinsR Graham Hope
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR and School of Applied Sciences, University of Glamorgan, Trefforrest, Cardiff CF37 1DL, United Kingdom
J Biol Chem 277:4261-70. 2002..These studies identify common features in disparate proteins that are required for lipid droplet localization...
- Viral hepatitis and primates: historical and molecular analysis of human and nonhuman primate hepatitis A, B, and the GB-related virusesB H Robertson
Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
J Viral Hepat 8:233-42. 2001..This review summarizes the historical and molecular information for each of these groups and highlights the impact of these nonhuman primate hepatitis viruses on our understanding of the evolution of each of these viruses...
- GB virus B as a model for hepatitis C virusB Beames
Department of Virology and Immunology, Southwest Foundation for Biomedical Research and Southwest Regional Primate Research Center, San Antonio, Texas, USA
ILAR J 42:152-60. 2001GB viruses A and B (GBV-A and GBV-B) are members of the Flaviviridae family and are isolated from tamarins injected with serum from a human hepatitis patient...
- Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytesR E Lanford
Department of Virology and Immunology, Southwest Regional Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
J Virol 75:8074-81. 2001....
- Serological and histological findings in infection and transmission of GBV-C/HGV to macaquesY Cheng
Department of Immunology, Institute of Infectious Diseases, Beijing, P R China
J Med Virol 60:28-33. 2000..It is possible that this virus is a mild and self-limited pathogenic agent to the hepatic cells of primates...
- Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related FlaviviridaeMaria Bretner
Institut Biochemii i Biofizyki, Polska Akademia Nauk, Warszawa, Poland
Antivir Chem Chemother 16:315-26. 2005..their N-alkyl derivatives were synthesized and tested for antihelicase activity against enzymes of selected Flaviviridae including hepatitis C virus (HCV), West Nile virus (WNV), Dengue virus (DENV) and Japanese encephalitis virus (..
- Homologous recombination in GB virus C/hepatitis G virusM Worobey
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, England
Mol Biol Evol 18:254-61. 2001..The wide-ranging implications of such nonclonal history for reconstructing the spread and timescale of GBV-C evolution are discussed...
- Genomic analysis of two GB virus A variants isolated from captive monkeysJ C Erker
Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IL 60064, USA
J Gen Virol 79:41-5. 1998..Although the GBV-A variant polyproteins possess many motifs conserved between other members of the Flaviviridae, they do not encode a basic core-like protein...
- Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agentJ Bukh
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892 0740, USA
Virology 262:470-8. 1999GB virus-B (GBV-B) is a member of the Flaviviridae family of viruses. This RNA virus infects tamarins, but its natural host is not known...
- A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmissionS Cook
Department of Zoology, University of Oxford, Oxford, UK
Arch Virol 151:309-25. 2006The genus Flavivirus (family Flaviviridae) presently comprises around 70 single-strand positive-sense RNA viruses...
- Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae foldAlexander E Aleshin
Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
Protein Sci 16:795-806. 2007..flaviviral proteases with the more distantly related Hepatitis C virus, we provide insights into the evolution of the Flaviviridae fold. Our work should expedite the design of protease inhibitors to treat a range of flaviviral infections.
- Structural and functional comparison of the non-structural protein 4B in flaviviridaeChristoph Welsch
Internal Medicine II, Saarland University Hospital, Kirrberger Strasse, 66421 Homburg Saar, Germany
J Mol Graph Model 26:546-57. 2007b>Flaviviridae are evolutionarily related viruses, comprising the hepatitis C virus (HCV), with the non-structural protein 4B (NS4B) as one of the least characterized proteins...
- The sequence and genomic organization of a GB virus A variant isolated from captive tamarinsT P Leary
Virus Discovery Group, Abbott Laboratories, Dept, North Chicago, IL 60064, USA
J Gen Virol 78:2307-13. 1997..Phylogenetic analysis of the polyprotein confirms previous results that GBV-Alab is a member of the Flaviviridae, distinct from GBV-B and HCV, though more closely related to GBV-A and GBV-C.
- RNA chaperoning and intrinsic disorder in the core proteins of FlaviviridaeRoland Ivanyi-Nagy
LaboRetro INSERM 758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, 69364 Lyon Cedex 07, France
Nucleic Acids Res 36:712-25. 2008..We now examined the RNA chaperone activity and the disordered nature of core proteins from different Flaviviridae genera, namely that of HCV, GBV-B (GB virus B), WNV (West Nile virus) and BVDV (bovine viral diarrhoea virus)...
- Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hostsR N Charrel
Laboratoire de Virologie Moleculaire, Transfusionnelle et Tropicale, Faculte de Medecine, Marseille, France
J Gen Virol 80:2329-35. 1999....
- The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitroS Steffens
Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat Giessen, Germany
J Gen Virol 80:2583-90. 1999..is required for replication of the positive-strand RNA genome, is a key enzyme of members of the virus family Flaviviridae. By using heterologously expressed proteins, we demonstrate that the 77 kDa NS5B protein of two pestiviruses, ..
- Isolation of a new flavivirus related to cell fusing agent virus (CFAV) from field-collected flood-water Aedes mosquitoes sampled from a dambo in central KenyaR C Sang
Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya
Arch Virol 148:1085-93. 2003..insect virus that was isolated from a line of Aedes aegypti mosquito cells and has been assigned to the family Flaviviridae, genus Flavivirus. We report here the first isolation of a CFA-like virus from field-collected mosquitoes...
- NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzymePeter Borowski
Abteilung fur Virologie, Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
Acta Biochim Pol 49:597-614. 2002..a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family...
- Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virusNing Zhang
Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
J Med Chem 46:4149-64. 2003..ring systems (30b, 30c, 32, and 34), have been synthesized as potential inhibitors of NTPases/helicases of Flaviviridae, including the West Nile virus (WNV), hepatitis C virus (HCV), and Japanese encephalitis virus (JEV)...
- Hemorrhagic fever viruses as biological weapons: medical and public health managementLuciana Borio
Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
JAMA 287:2391-405. 2002..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
- Broad-spectrum inhibitor of viruses in the Flaviviridae familyJoshua O Ojwang
ZymeTx Inc, 655 Research Parkway, Suite 554 Oklahoma City, OK 73104, USA
Antiviral Res 68:49-55. 2005The viruses in the Flaviviridae family have been associated with human and animal diseases...
- Activity of Mannich bases of 7-hydroxycoumarin against FlaviviridaeMauro Mazzei
Department of Pharmaceutical Sciences, Viale Benedetto XV, 3, 16132 Genova, Italy
Bioorg Med Chem 16:2591-605. 2008..This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV)...
- An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranosideRavi K Ujjinamatada
Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Bioorg Med Chem Lett 17:2285-8. 2007..Compound 4 was evaluated in vitro against NTPases/helicases of four different viruses of the Flaviviridae family, including the West Nile virus (WNV), hepatitis C virus (HCV), dengue virus (DENV), and the Japanese ..
- Early acquisition of TT virus in infants: possible minor role of maternal transmissionHo Hsiung Lin
Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan
J Med Virol 66:285-90. 2002..In conclusion, TTV viremia is common in pregnant Taiwanese women and their infants. However, the results suggest that maternal transmission may play only a minor role in early acquisition of TTV in infants...
- Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerasesBarbara Selisko
Centre National de la Recherche Scientifique and Universités d Aix Marseille I et II, UMR 6098, Architecture et Fonction des Macromolecules Biologiques, AFMB CNRS ESIL, 13288 Marseille Cedex 9, France
Virology 351:145-58. 2006..In contrast to the RdRps of hepaci- and pestiviruses, which belong to the same family of Flaviviridae, NS5 carries two activities, a methyltransferase (MTase) and a RdRp...
- GB virus C and TT virus infections in Japanese patients with autoimmune hepatitisShuhei Nishiguchi
Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
J Med Virol 66:258-62. 2002..These findings provide no compelling evidence that GBV-C or TTV has a pathogenic role in autoimmune hepatitis...
- Prevalence of GB virus C (hepatitis G virus) and risk factors for infection in São Paulo, BrazilG Ribeiro-dos-Santos
Fundação Pró Sangue Hemocentro de São Paulo, Avenida Dr Enéas de Carvalho Aguiar 155 1 Andar, 05403 000 Sao Paulo, Brazil
Eur J Clin Microbiol Infect Dis 21:438-43. 2002..5; 95%CI 1.2-5.4) were independently associated with GBV-C infection. In conclusion, the prevalence of GBV-C infection is high in São Paulo. In addition to parenteral transmission, another route, e.g. sexual or vertical, may be involved...
- [Virus isolated in the human blood leukocyte culture and its interaction with hepatitis C and G viruses]I F Barinskii
Vopr Virusol 48:30-5. 2003..Therefore, the HLV was described as belonging to the Flaviviridae family...
- [Replication strategies of the Flaviviridae family]Luminiţa Popa
I N C D M I Cantacuzino, Bucuresti
Bacteriol Virusol Parazitol Epidemiol 48:75-92. 2003
- Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae virusesMaria Bretner
Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
Antivir Chem Chemother 15:35-42. 2004..The above derivatives were tested as inhibitors of nucleoside triphosphatase (NTPase)/helicase activities of Flaviviridae: hepatitis C virus (HCV), West Nile virus (WNV), Japanese encephalitis virus (JEV) and dengue virus (DENV) and ..
- Expectoration of Flaviviruses during sugar feeding by mosquitoes (Diptera: Culicidae)Andrew F van den Hurk
Virology, Queensland Health Scientific Services, Coopers Plains, Australia, 4108
J Med Entomol 44:845-50. 2007..Skuse and Culex gelidus Theobald (Diptera: Culicidae) were orally infected with Japanese encephalitis (family Flaviviridae, genus Flavivirus, JEV), Kunjin (family Flaviviridae, genus Flavivirus, KUNV; a subtype of West Nile virus), ..
- [Haemorrhagic fever viruses, possible bioterrorist use]Sophie Rigaudeau
Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
Presse Med 34:169-76. 2005..These viruses belong to one of the following families: filoviridae, arenaviridae, bunyaviridae, and flaviviridae. They must be considered as dangerous biological weapons that could potentially be used...
- [The use of monoclonal antibodies in studying the causative agents of viral hemorrhagic fevers]G V Borisevich
Vopr Virusol 48:4-8. 2003..The methodological specificity of obtaining the Mabs to viral hemorrhagic-fevers' agents as well as data on its practical use are discussed...
- The role of reverse genetics systems in studying viral hemorrhagic feversHideki Ebihara
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
Thromb Haemost 94:240-53. 2005..Here we review the existing reverse genetics systems for VHF causing viruses and discuss their use in studying viral replication, pathogenesis, and the development of antivirals and vaccines...
- [OAS genes and susceptibility to West Nile virus]Jean Louis Guenet
Med Sci (Paris) 19:9-12. 2003
- [Dengue and other hemorrhagic viral fevers]Cristina Domingo-Carrasco
Laboratorio de Arbovirus y Enfermedades Víricas Importadas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
Enferm Infecc Microbiol Clin 23:615-26. 2005..Even today many factors related to origin, pathogenesis, treatment and control of these diseases remain uncertain...
- Detection of the negative-strand hepatitis C virus RNA in tissues: implications for pathogenesisR Quadri
Division of Gastroenterology and Hepatology, University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Antiviral Res 52:161-71. 2001..This is based on the comparison with the replication of other members of the Flaviviridae family...
- Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae virusesMaria Bretner
Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawińskiego Str, 02 106 Warszawa, Poland
Acta Pol Pharm 61:26-8. 2004..The N-alkyl derivatives showed good activity and lower cytotoxicity than TBBT...
- Prevalence of hepatitis B, hepatitis C, GB virus C/hepatitis G and TT viruses in predialysis and hemodialysis patientsJ M Lopez-Alcorocho
Department of Hepatology, Fundación Jiménez Díaz and Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain
J Med Virol 63:103-7. 2001..In conclusion, the prevalence of the viruses studied in predialysis may influence their prevalence in dialysis units...
- Evolutionarily conserved RNA secondary structures in coding and non-coding sequences at the 3' end of the hepatitis G virus/GB-virus C genomeN M Cuceanu
Laboratory for Clinical and Molecular Virology, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
J Gen Virol 82:713-22. 2001..The prediction of similar structures in the same region of hepatitis C virus may allow the functions of these structures to be determined with a more tractable experimental model...
- Molecular characteristic-based epidemiology of hepatitis B, C, and E viruses and GB virus C/hepatitis G virus in MyanmarK Nakai
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
J Clin Microbiol 39:1536-9. 2001..These results suggest that these hepatitis virus infections are widespread in Myanmar and have led to a high incidence of acute and chronic liver disease patients in the region...
- The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAsR Rijnbrand
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555-1019, USA
RNA 7:585-97. 2001....
- TTV infection and its relation to serum transaminases in apparently healthy blood donors and in patients with clotting disorders who have been investigated previously for hepatitis C virus and GBV-C/HGV infection in BelgiumSoegianto Ali
Division of Liver and Pancreatic Diseases, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
J Med Virol 66:561-6. 2002..TTV does not cause liver disease or contribute to the severity of liver disease...
- Experimental Usutu virus infection of suckling mice causes neuronal and glial cell apoptosis and demyelinationHerbert Weissenbock
Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
Acta Neuropathol 108:453-60. 2004..While neuronal apoptosis is a general aspect of flavivirus pathogenicity, demyelination seems to be a unique feature of USUV infection...
- Pseudo-peptides derived from isomannide as potential inhibitors of serine proteasesE M F Muri
Instituto de Quimica, Universidade do Brasil, Cidade Universitaria, CT Bloco A, Rio de Janeiro, Brasil
Amino Acids 28:413-9. 2005..In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors...
- Hepatitis C virus: clades and propertiesColin R Howard
Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, London, UK
J Gastroenterol Hepatol 17:S468-70. 2002Hepatitis C virus (HCV) is a member of the virus family Flaviviridae. At present HCV is classified into a discrete hepacivirus genus and is represented by six clades according to genome sequencing...
- Vaccines and animal models for arboviral encephalitidesAysegul Nalca
Homeland Security and Infectious Disease Research Division, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
Antiviral Res 60:153-74. 2003..The most significant arboviruses causing human illness belong to genera in three viral families, Togaviridae, Flaviviridae, and Bunyaviridae...
- 5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae virusesM Bretner
Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
Nucleosides Nucleotides Nucleic Acids 22:1531-3. 2003..Synthesis and interactions of guanosine, inosine and ribavirin 5'-fluorosulfonylbenzoyl esters with hepatitis C virus (HCV) and Flaviviruses NTPase/helicase and polymerase are described...
- Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 ATetsuo Yamashita
Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Virology 373:426-36. 2008..The detailed structural comparison among the viruses of the family Flaviviridae should help in clarifying the molecular mechanism of viral replication and in providing rationale for the ..
- Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI)Peter Borowski
Department of Molecular Biology, Institute of Environmental Protection, John Paul II Catholic University of Lublin, Al Krasnicka 102, 20 718 Lublin, Poland
Biochem Pharmacol 76:28-38. 2008The NTPase/helicase of Flaviviridae viruses is one of the essential components of their replication complex. The enzyme is defined by the presence of seven highly conserved amino acid motifs...
- Mutagenesis analysis of the NS2B determinants of the Alkhurma virus NS2B-NS3 protease activationBoris A M Pastorino
Unité de Virologie Tropicale, Institut de Médecine Tropicale du Service de Santé des Armées IMTSSA, BP 46, 13998 Marseille Armees, France
J Gen Virol 87:3279-83. 2006..The results also determine residues in the ALKV NS2B cofactor essential for protease activation, giving new insights into protease function in flaviviruses...
- Assessment of substrate specificity of hepatitis G virus NS3 protease by a genetic methodY J Lee
Department of Life Science and National Research Laboratory of Proteolysis, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju 500-712, Korea
Biochem Biophys Res Commun 286:171-5. 2001..Our result would provide an insight on the molecular activity of the NS3 protease and may be useful for the design of substrate-based inhibitors...
- Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 proteaseAloke K Bera
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 282:12883-92. 2007..Formation of an active protease was found to require neither cleavage of NS2B from NS3 nor a free NS3 N terminus. Evidence was also obtained for product inhibition of the protease by the cleaved C terminus of NS2B...
- Design, synthesis and anti flaviviridae activity of N(6)-, 5',3'-O- and 5',2'-O-substituted adenine nucleoside analogsAngela Angusti
Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
Chem Pharm Bull (Tokyo) 56:423-32. 2008..libraries of nucleoside analogues we discovered that the adenine derivatives FEVB28 and FEG118 were Flaviviridae inhibitors endowed with potency comparable, if not superior, to that of ribavirin...
- Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B repliconAmedeo De Tomassi
Istituto di Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
J Virol 76:7736-46. 2002..The replication of GBV-B subgenomic RNA was susceptible to inhibition by known inhibitors of HCV to a level similar to that of HCV subgenomic RNA...
- Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteinsJames R Jacob
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, NY 14853, USA
J Microbiol 45:431-40. 2007..1-DNJ, was demonstrated against bovine viral diarrhea virus (BVDV) and GB virus-B (GBV-B), both members of the Flaviviridae family, and against woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV), both members of the ..
- Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamidesA Carta
Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
Med Chem 3:520-32. 2007..e. Enterovirus Coxsackie B2 (CVB-2) and Polio (Sb-1)] and of two of the three genera of the Flaviviridae [Bovine Viral Diarrhea Virus (BVDV) and Yellow Fever Virus (YFV)]...
- West Nile virus vaccinesRoy A Hall
Department of Microbiology and Parasitology, The University of Queensland, Brisbane, Queensland 4072, Australia
Expert Opin Biol Ther 4:1295-305. 2004..Levels of efficacy and safety, as well as logistical, economic and environmental issues, must all be carefully considered before vaccine candidates are approved and selected for large-scale manufacture and distribution...
- Prevalence of a novel DNA virus (TTV) among patients on maintenance hemodialysisM Schroter
Institut fur Medizinische Mikrobiologie und Immunologie, Universitats Krankenhaus Eppendorf, Hamburg, Deutschland
Nephron 87:139-42. 2001..A recently detected DNA virus (TTV) has been assumed to be responsible for posttransfusion hepatitis in humans. Until now it is unclear whether patients on maintenance hemodialysis are at increased risk of acquiring TTV...
- Old bugs and new: classical and emerging pathogens--relevance to dental practiceJoan Power
Munster Regional Transfusion Centre, St Finbarr s Hospital, Douglas, Cork
J Ir Dent Assoc 50:79-80. 2004
- Effect of coinfection with GB virus C on survival among patients with HIV infectionJ Xiang
Department of Internal Medicine and Research, Iowa City Veterans Affairs Medical Center, and the University of Iowa College of Medicine, USA
N Engl J Med 345:707-14. 2001..CONCLUSIONS: GBV-C infection is common in people with HIV infection and is associated with significantly improved survival...
- Reliable detection of St. Louis encephalitis virus by RT-nested PCRViviana Re
Instituto de Virologia Dr J M Vanella, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
Enferm Infecc Microbiol Clin 26:10-5. 2008..Herein, we report the development of a species-specific RT-nested PCR to detect SLEV...
- The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic areaM L Yu
Hepatobiliary Division, Department of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
J Infect 42:61-6. 2001..HCV viraemia played the most important clinical hepatopathic role in the area. Infections with other hepatitis viruses did not influence the anti-E2 seroconversion from GBV-C/HGV infections...
- A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-derived zinc-chelating trioxa-adamantane-triolAndreas J Kesel
Chammünsterstr 47, D 81827 München, Germany
Bioorg Med Chem 11:4599-613. 2003..wide RNA virus selection including Picornaviridae (poliovirus, human coxsackievirus, hepatitis A virus), Flaviviridae (yellow fever virus, Dengue virus, West Nile virus, Kunjin virus, St...
- Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006William K Reisen
Arbovirus Research Unit, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Old Davis Rd, Davis, CA 95616, USA
J Med Entomol 45:494-508. 2008West Nile virus (family Flaviviridae, genus Flavivirus, WNV) invaded the Colorado Desert biome of southern California during summer 2003 and seemed to displace previously endemic St...
- Tick-borne virusesM Labuda
Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
Parasitology 129:S221-45. 2004..found in six different virus families (Asfarviridae, Reoviridae, Rhabdoviridae, Orthomyxoviridae, Bunyaviridae, Flaviviridae) and at least 9 genera...
- Arbovirus infections and viral haemorrhagic fevers in Uganda: a serological survey in Karamoja district, 1984F Rodhain
Unité d Ecologie des Systèmes Vectoriels, Institut Pasteur, Paris, France
Trans R Soc Trop Med Hyg 83:851-4. 1989..Forest alphaviruses (Togaviridae); dengue type 2, Wesselsbron, West Nile, yellow fever and Zika flaviviruses (Flaviviridae); Bunyamwera, Ilesha and Tahyna bunyaviruses (Bunyaviridae); and Sicilian sandfly fever phlebovirus (..
- [Dengue fever: from disease to vaccination]R Teyssou
Sanofi Pasteur Lyon, France
Med Trop (Mars) 69:333-4. 2009..Dengue iscaused by an arbovirus belonging to the Flavivirus genus of the family Flaviviridae. There are four dengue virus serotypes and no cross protection between them...
- Ability of transstadially infected Ixodes pacificus (Acari: Ixodidae) to transmit West Nile virus to song sparrows or western fence lizardsW K Reisen
Center for Vectorborne Diseases and Department of Pathology, Immunology, and Microbiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Med Entomol 44:320-7. 2007..pacificus Cooley & Kohls (Acari: Ixodidae) may serve as a reservoir and vector of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) in California was tested by determining the ability of this tick species to become ..
- Epidemiology of hemorrhagic fever virusesJ W LeDuc
Disease Assessment Division, U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701 5001
Rev Infect Dis 11:S730-5. 1989..hemorrhagic fever, and Hantaan viruses; Filoviridae, which includes Marburg and Ebola viruses; and Flaviviridae, which includes yellow fever, dengue, Kyasanur Forest disease, and Omsk viruses...
- Microclimate and the zoonotic cycle of tick-borne encephalitis virus in SwitzerlandC Burri
Institute of Biology, Laboratory of Eco Epidemiology of Parasites, University of Neuchatel, Emile Argand 11, 2000 Neuch and tel, Switzerland
J Med Entomol 48:615-27. 2011The focal distribution of tick-borne encephalitis virus (TBEV; Flaviviridae, Flavivirus) appears to depend mainly on cofeeding transmission between infected Ixodes ricinus L. nymphs and uninfected larvae...
- Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoesC D Blair
Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523 1677, USA
Clin Microbiol Rev 13:651-61. 2000..virus (LAC) (a member of the Bunyaviridae) and dengue viruses serotypes 1 to 4 (DEN-1 to DEN-4) (members of the Flaviviridae) were expressed in mosquito cells from double-subgenomic and replicon vectors based on Sindbis virus (a member ..
- [Tick-borne human pathogenic microorganisms found in Europe and those considered nonpathogenic. Part I: Ticks and Viruses]J Süss
Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Standort Jena, Jena
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:392-404. 2004..Among these ticks, viruses from 6 families encompassing 8 genera and 35 species are found,whereby the families Flaviviridae, Bunyaviridae, and Reoviridae with the genera flavivirus, nairovirus, and orbivirus are the most prevalent...
- Comparison of immune responses of brown-headed cowbird and related blackbirds to west Nile and other mosquito-borne encephalitis virusesWilliam K Reisen
Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Wildl Dis 43:439-49. 2007The rapid geographic spread of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) across the United States has stimulated interest in comparative host infection studies to delineate competent avian hosts critical for viral ..
- Evolutionary influences in arboviral diseaseS C Weaver
Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Curr Top Microbiol Immunol 299:285-314. 2006..which have probably limited the evolution of arboviruses to only a few families of RNA viruses (Togaviridae, Flaviviridae, Bunyaviridae, Rhabdoviridae, Reoviridae, and Orthomyxoviridae) and a single DNA virus...
- Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesiclesAnna K Overby
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D 79008 Freiburg, Germany
J Virol 84:8470-83. 2010Tick-borne encephalitis virus (TBEV) (family Flaviviridae, genus Flavivirus) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia...
- Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristicsAlexander T Ciota
The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA
PLoS ONE 4:e7876. 2009St. Louis encephalitis virus (SLEV; Flaviviridae, flavivirus) was the major cause of epidemic flaviviral encephalitis in the U.S. prior to the introduction of West Nile virus (WNV) in 1999...
- Evidence for the presence of two novel pestivirus speciesR Avalos-Ramirez
Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat, Giessen, D 35392, Germany
Virology 286:456-65. 2001The genus Pestivirus of the family Flaviviridae comprises four species, namely Bovine viral diarrhea virus-1 (BVDV-1), BVDV-2, Border disease virus (BDV), and Classical swine fever virus (CSFV)...
- Insect-transmitted vertebrate viruses: flaviviridaeG V Ludwig
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702
In Vitro Cell Dev Biol Anim 29:296-309. 1993The Flaviviridae include almost 70 viruses, nearly half of which have been associated with human disease...
- C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference responseDoug E Brackney
Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
PLoS Negl Trop Dis 4:e856. 2010..C6/36 and Drosophila melanogaster S2 cells were infected with WNV (Flaviviridae), Sindbis virus (SINV, Togaviridae) and La Crosse virus (LACV, Bunyaviridae) and total RNA recovered from cell ..
- The effects of hepatitis C virus (HCV) E2 protein on host immunomodulationJack T Stapleton; Fiscal Year: 2013..Identification and characterization of this HCV E2 - lymphocyte interaction may contribute to the development of novel therapeutic and/or vaccine approaches to HCV, and potentially to related viruses within the Flaviviridae.
- Bioavailable proteasome inhibitors as broad-spectrum antiviralsALEXANDER NICLAS FREIBERG; Fiscal Year: 2013..Category A-C pathogens: Filoviridae (Ebola), Paramyxoviridae (Nipah), Bunyaviridae (Rift Valley fever), Flaviviridae (Russian-Spring-Summer encephalitis), and Arenaviridae (Junin)...
- Deep Sequencing for the Detection of Viral Sequences in Primary Progressive MultiJohn D Kriesel; Fiscal Year: 2012..These initial sequencing data have led to an intriguing candidate virus: GBV-C, a member of the Flaviviridae family never recovered before from a human brain...
- Dengue Virus Genome Encapsidation and Its Interplay with Host Lipid DropletsAndrea Gamarnik; Fiscal Year: 2013DESCRIPTION (provided by applicant): Dengue virus, a member of the Flaviviridae family, is a Category A pathogen that causes the most prevalent arthropod-borne viral illnesses in humans...
- Mechanisms for cell uptake of LDL/DNA complexesNATALIA V GUEVARA; Fiscal Year: 2013..as potential B/E receptor binding sites based on presence R/K-rich motifs similar to those in to apo E and in Flaviviridae proteins...
- Broad-spectrum, small-molecule inhibitors of bunyavirusesRobert D Allen; Fiscal Year: 2010..activities that extend beyond the family Bunyaviridae against viruses in the Poxviridae, Togaviridae, and Flaviviridae families, presumably by targeting host pathways essential for replication of a diversity of virus families...
- Genetic viral and host adaptations to breach species barriers of HCVAlexander Ploss; Fiscal Year: 2013..hepatitis C, which is caused by hepatitis C virus (HCV) - a positive sense, single-stranded RNA virus of the Flaviviridae family. HCV has a high propensity for establishing chronic infection...
- Retrocyclin reinforcement of pulmonary defenses against viral aerosolsRobert Lehrer; Fiscal Year: 2007..including Influenza A and B (Orthomyxoviridae), HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia (Poxviridae), VEE, an alphavirus (Togaviridae), and Tacaribe virus (..
- Host factor DNAJC14 as a novel target for broad spectrum anti-flavivirus activityMargaret R Macdonald; Fiscal Year: 2010..inhibition may lead to strategies to prevent infection and/or disease caused by human pathogenic viruses in the Flaviviridae family...
- Genetic determinants of adaptation of two flavivirusesLaura D Kramer; Fiscal Year: 2013DESCRIPTION (provided by applicant): The emergence and rapid biogeographic expansion of West Nile Virus (WNV;Flaviviridae;Flavivirus) throughout the western hemisphere, as well as the re-emergence of other medically significant viruses, ..
- A biomimetic nanoparticle protease assay platformSteven W Graves; Fiscal Year: 2013..cleave protein targets (substrates) important in the progression of disease, like viral processing by the flaviviridae, toxin cleavage of proteins, and digestion of the extracellular matrix during cancer metastasis...
- STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASEKrishna Murthy; Fiscal Year: 2004DESCRIPTION (adapted from the applicant's abstract): Dengue viruses, members of the Flaviviridae are recognized as the causative agent or one of the most important mosquito-borne viral diseases of humans affecting 100 million people ..
- ANTIVIRAL DRUG DELIVERY WITH LYOPHILIZED PLATELETSThomas Fischer; Fiscal Year: 2004..Lassa fever virus), Filoviridae (e.g., Ebola and Marburg viruses), Bunyaviridae (e.g., Rift Valley virus) and Flaviviridae (e.g...
- FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5Radhakrishnan Padmanabhan; Fiscal Year: 2003Dengue viruses, members of Flaviviridae, are recognized as the causative agent of mosquito borne viral diseases affecting about 100 million people annually...
- Automated Simultaneous Detection of Bioterrorism AgentsDavid Ecker; Fiscal Year: 2005..development and validation for NIAID/CDC-priority pathogens such as the Poxviridae, Arenaviridae, Bunyaviridae, Flaviviridae, Togaviridae (especially VEE), and Filoviridea families and the alpha, beta, gamma-proteobacteria...
- Antiviral agents for Flavivirus infections of bioterrorTimothy Block; Fiscal Year: 2003..and develop a new class of antiviral compounds, we call "glucovirs", for the treatment of members of the flaviviridae family such as West Nile Encephalitis Virus, Yellow Fever (WNEV, YFV respectively) and Powassan viruses (PV) ..
- Latin America Workshop On DengeJorge Osorio; Fiscal Year: 2009..provided by applicant): Dengue viruses (DENV) include four serotypes (DENV-1 - DENV-4) that belong to the Flaviviridae family and cause the most important arthropod-borne viral infection of humans with about 100 million cases and ..
- Screening for antivirals against flavivirusesPAUL OLIVO; Fiscal Year: 2003..Some VHF agents have been suspect for abuse in biowarfare/bioterrorism. Members of the family Flaviviridae are among the viral agents that cause VHF...
- Chimeric hepatitis C vaccine vectorJACK NUNBERG; Fiscal Year: 2004..HCV is an enveloped RNA virus in the Flaviviridae family, which also includes the Flavivirus and Pestivirus genera...
- DENGUE CONTROL IN MOSQUITOES BY SINGLE CHAIN ANTIBODIESKENNETH OLSON; Fiscal Year: 1999..The lack of effective vaccines against DEN viruses (serotypes 1-4; Flaviviridae), the collapse of mosquito control programs in many developing countries, and the emergence of pesticide ..
- Intracellular Assembly of the Coronavirus, IBVCarolyn Machamer; Fiscal Year: 2005..These include Bun yaviridae and Flaviviridae. The long term goals of the proposed experiments are to elucidate the mechanism and advantages of intracellular ..
- Functional Analysis of HCV-B Lymphocyte InteractionsThomas Chambers; Fiscal Year: 2003The hepatitis C viruses (HCV) are small RNA viruses within the family Flaviviridae, distinguished from other members by their capacity to cause persistent infection in humans with serious consequences such as chronic active hepatitis, ..
- HEPATITIS C VIRUS AND HEPATOCELLULAR CARCINOMA ASrikanta Dash; Fiscal Year: 2000..Hepatitis C virus (HCV), a small positive-sense RNA virus of the Flaviviridae family, is the major cause of hepatitis in the United States and often leads to chronic hepatitis, cirrhosis ..
- Effect of Thiopurines on RNA Viruses/Hepatitis C VirusRobert Striker; Fiscal Year: 2005Viruses from the Family Flaviviridae, including West Nile Virus, Dengue Virus and Hepatitis C Virus (HCV), are significant causes of morbidity and mortality, yet have few to no treatment options...
- Replication Elements in the 5' End of the HCV GenomeMinkyung Yi; Fiscal Year: 2004Hepatitic C virus (HCV) is the single member of the genus hepacivirus in the family Flaviviridae. The genome consists of a single positive-stranded RNA molecule...
- Immunogenicity of Hepatitis C Virus (HCV) like particlesGlen Barber; Fiscal Year: 2007Hepatitis C virus [HCV], a member of the Flaviviridae, is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma...
- RNA-Protein Interactions in the Flaviviridae viruses.RAUL GOMILA; Fiscal Year: 2003..Therefore, the elucidation of the molecular mechanism of interaction between the RNA and proteins of these viruses could be important in order to design effective antiviral therapies. ..
- Small Molecules as Research Tools for HCV BiologyCharles Rice; Fiscal Year: 2004..Inhibitory, non-cytotoxic compounds will be counter-screened against other members of the Flaviviridae family, including bovine viral diarrhea virus and yellow fever virus...
- Developing antiviral agents that inhibit HCV translationZHENGXIAN GU; Fiscal Year: 2005..Thus, it is necessary to develop new anti-HCV drugs. HCV is a member of the family Flaviviridae. The HCV genome contains a long, single open reading frame mRNA that encodes the viral proteins...
- Defining NS4B Function in Hepatitis C Virus ReplicationKeril J Blight; Fiscal Year: 2010..whose function in HCV replication is the least understood not only in HCV, but also in other members of the Flaviviridae family...
- Developing antiviral agents that inhibit HCV translationZHENGXIAN GU; Fiscal Year: 2003..Thus, it is necessary to develop new anti-HCV drugs. The HCV is a member of the family Flaviviridae. The HCV genome contains a long, single open reading frame mRNA that encodes the viral proteins...
- ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDSWilliam Reisen; Fiscal Year: 2002..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..
- HOST COMPETENCE FACTORS AFFECT ARBOVIRUS TRANSMISSIONWilliam Reisen; Fiscal Year: 2003..Studies will assess how alternating sequential infections between vertebrate and vector species that are part of the natural transmission cycle may alter virus genetics and fitness. ..
- Trafficking, persistence and evolution of HIV in the CNSPeter Simmonds; Fiscal Year: 2005....
- HIV-1 Tat modulation of HCV replication and pathogenesisRobert Garry; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Peptide drugs against influenza virusRobert Garry; Fiscal Year: 2007..The studies proposed in this application will address an urgent public health and biodefense need for new drugs that are effective against influenza viruses. [unreadable] [unreadable]..
- Rapid screen for Ebola virus membrane interactions/drugsRobert Garry; Fiscal Year: 2005....
- ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITISScott Weaver; Fiscal Year: 2005..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
- Recombinant antigen assays for Lassa and other arenaviruRobert Garry; Fiscal Year: 2005....
- Rapid screen for HIV TM membrane interactions/drugsRobert Garry; Fiscal Year: 2004..The approaches piloted here may be useful for developing drugs against the AIDS virus and a broad range of important human viral pathogens with similar fusion proteins. ..
- Structure and size determination of S. aureus pathogenicity island capsidsTerje Dokland; Fiscal Year: 2008..The bacteriophage/pathogenicity island system is of special interest for its role in transferring toxin genes and conferring pathogenicity on non-pathogenic strains. [unreadable] [unreadable] [unreadable]..
- INITIATION OF HEPATITIS C VIRUS TRANSLATIONCHRISTOPHER HELLEN; Fiscal Year: 2001..abstract_text> ..
- HCV-ALCOHOL INTERACTIONS-- PATHOGENESIS AND EPIDEMIOLOGYJack Stapleton; Fiscal Year: 2001..These studies may lead to insights on the mechanism of liver injury and help define those patients who are most likely to have progressive liver injury. ..
- HEPATITIS C VIRUS IN ETIOLOGY OF WA RHEUMATOID FACTORSVincent Agnello; Fiscal Year: 2001..We have also established that the LDL receptor mediates endocytosis of HCV and other members of the Flaviviridae family and that the apolipoprotein E epsilon2 allele in HCV infected patients increases the risk of developing ..
- LIVE, ATTENUATED, RECOMBINANT VACCINE - WEST NILE VIRUSThomas Monath; Fiscal Year: 2002..abstract_text> ..
- Functional analysis of flavivirus genetic resistance.Margo A Brinton; Fiscal Year: 2010..This research is relevant to understanding individual variation in the response to flavivirus infections among humans. ..
- MOLECULAR GENETIC MARKERS FOR TICK VECTORSHARRY HUTCHESON; Fiscal Year: 2002..I.) pacificus and I. (Ixodiopsis) woodi using 3 B. burgdorferi strains from the northeastern, southeastern, and western regions of the USA. ..
- Development of Inhibitors Against HCV InfectionJoshua Ojwang; Fiscal Year: 2002..abstract_text> ..
- Development of a new model of viral hemorrhagic fever. MARGO BRINTON; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Arbovirus quasispecies-impact of arthropod transmissionGREGORY EBEL; Fiscal Year: 2004..abstract_text> ..
- Molcular detection of weaponized arenavirusesRemi Charrel; Fiscal Year: 2003..The ultimate goal is to propose a ready-to-use diagnostic kit for the detection and characterization of weaponized arenaviruses. ..
- Oas-1 gene transgenic mice for WNV research.MARGO BRINTON; Fiscal Year: 2005....
- INTERFERON IN MODULATING DENGUE VIRUS INFECTIONMichael Diamond; Fiscal Year: 2002....
- West Nile Virus Genotypic Affect on Host CompetenceAARON BRAULT; Fiscal Year: 2006..abstract_text> ..
- Immunotherapy of hepatitis C virus infection.Eric Gowans; Fiscal Year: 2006..The effect on the viral load in the liver disease will be measured by quantitative RT-PCR and ALT levels, respectively, and correlated with the markers of the cellular immune response described above. [unreadable] [unreadable]..
- Ethnobotanical Anti-Respiratory Syncytial Virus DrugsJoshua Ojwang; Fiscal Year: 2003..proposed commercial application: not available ..
- West Nile Viral Determinants of Avian PathogenesisAARON BRAULT; Fiscal Year: 2007..In addition, fundamental knowledge of viral replication and pathogenesis will provide insight for the development of vaccine and antiviral strategies. [unreadable] [unreadable]..
- Lamin A Mutation and Hutchinson-Gilford ProgeriaHoward Worman; Fiscal Year: 2008..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
- Lamin A in Adipocyte Differentation and SurvivalHoward Worman; Fiscal Year: 2004..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..