flaviviridae

Summary

Summary: A family of RNA viruses, many of which cause disease in humans and domestic animals. There are three genera FLAVIVIRUS; PESTIVIRUS; and HEPACIVIRUS, as well as several unassigned species.

Top Publications

  1. pmc Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts
    Francisco P Lobo
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 4:e6282. 2009
  2. pmc The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
    Jack T Stapleton
    Department of Internal Medicine, Veterans Administration Medical Center and the University of Iowa, Iowa City, IA, USA
    J Gen Virol 92:233-46. 2011
  3. pmc Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    V Agnello
    Lahey Clinic Medical Center, Department of Laboratory Medicine, Burlington, MA 01805, USA
    Proc Natl Acad Sci U S A 96:12766-71. 1999
  4. pmc Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh
    Jonathan H Epstein
    Conservation Medicine Program, Wildlife Trust, New York, New York, United States of America
    PLoS Pathog 6:e1000972. 2010
  5. ncbi Taxonomy of the virus family Flaviviridae
    Charles H Calisher
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Adv Virus Res 59:1-19. 2003
  6. pmc Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis
    C T Ranjith-Kumar
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    J Virol 75:8615-23. 2001
  7. pmc Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins
    A S Belyaev
    Genelabs Technologies, Inc, Redwood City, California 94063, USA
    J Virol 72:868-72. 1998
  8. ncbi Defective adenoviruses as novel vaccines for the Flaviviridae
    J Stephenson
    London School of Hygiene and Tropical Medicine, Division of Infectious and Tropical Medicine, UK
    Clin Diagn Virol 10:187-94. 1998
  9. ncbi Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent
    J Linnen
    Genelabs Technologies, Redwood City, CA 94063, USA
    Science 271:505-8. 1996
  10. pmc G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication
    Caroline Le Sommer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Negl Trop Dis 6:e1820. 2012

Detail Information

Publications216 found, 100 shown here

  1. pmc Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts
    Francisco P Lobo
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 4:e6282. 2009
    ..b>Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or invertebrate ..
  2. pmc The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
    Jack T Stapleton
    Department of Internal Medicine, Veterans Administration Medical Center and the University of Iowa, Iowa City, IA, USA
    J Gen Virol 92:233-46. 2011
    ..B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the ..
  3. pmc Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    V Agnello
    Lahey Clinic Medical Center, Department of Laboratory Medicine, Burlington, MA 01805, USA
    Proc Natl Acad Sci U S A 96:12766-71. 1999
    Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by low density lipoprotein (LDL) receptors on cultured cells by several lines of ..
  4. pmc Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh
    Jonathan H Epstein
    Conservation Medicine Program, Wildlife Trust, New York, New York, United States of America
    PLoS Pathog 6:e1000972. 2010
    ..Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.
  5. ncbi Taxonomy of the virus family Flaviviridae
    Charles H Calisher
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Adv Virus Res 59:1-19. 2003
  6. pmc Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis
    C T Ranjith-Kumar
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    J Virol 75:8615-23. 2001
    ....
  7. pmc Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins
    A S Belyaev
    Genelabs Technologies, Inc, Redwood City, California 94063, USA
    J Virol 72:868-72. 1998
    ..NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu1561, and Ala1598...
  8. ncbi Defective adenoviruses as novel vaccines for the Flaviviridae
    J Stephenson
    London School of Hygiene and Tropical Medicine, Division of Infectious and Tropical Medicine, UK
    Clin Diagn Virol 10:187-94. 1998
    ..Other diseases such as dengue fever (DF) and hepatitis C are still major public health problems as no licensed vaccines are in use...
  9. ncbi Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent
    J Linnen
    Genelabs Technologies, Redwood City, CA 94063, USA
    Science 271:505-8. 1996
    ..Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States...
  10. pmc G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication
    Caroline Le Sommer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Negl Trop Dis 6:e1820. 2012
    ..propagation of DENV and Hepatitis C virus (HCV) indicating that GRK2 requirement is conserved throughout the Flaviviridae. Finally, we found that GRK2 participates in multiple distinct steps of the flavivirus life cycle by promoting ..
  11. ncbi Dynamics of GB virus C viremia early after orthotopic liver transplantation indicates extrahepatic tissues as the predominant site of GB virus C replication
    T Berg
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Berlin
    Hepatology 29:245-9. 1999
    ..However, one cannot exclude that host or viral factors exist that predispose GBV-C replication predominantly in the liver...
  12. ncbi A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa
    M A Sathar
    Department of Medicine, University of Natal King Edward VIII Hospital, South Africa
    Virus Res 64:151-60. 1999
    ..None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates...
  13. ncbi Biophysical characterization of GB virus C from human plasma
    S L Melvin
    Virus Discovery Group, Experimental Biology Research, Abbott Diagnostic Division, Abbott Laboratories, North Chicago, IL 60064, USA
    J Virol Methods 71:147-57. 1998
    ..The treated material was non-filterable and the RNA had a density of > 1.5 gm/ml...
  14. pmc Species-specific variants of GB virus A in captive monkeys
    T P Leary
    Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, Illinois 60064, USA
    J Virol 70:9028-30. 1996
    ..Though sequences of isolates from each animal species are virtually identical at the nucleotide level (95%), isolates from different species are dramatically different (52 to 79% identical) and genetically cluster on this basis...
  15. pmc Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis
    Catherine L Murray
    The Rockefeller University, New York, NY 10065, USA
    Nat Rev Microbiol 6:699-708. 2008
    Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide...
  16. ncbi Expression of the GB virus C E2 glycoprotein using the Semliki Forest virus vector system and its utility as a serologic marker
    T J Pilot-Matias
    Virus Discovery Group, Diagnostics Division, Abbott Laboratories, North Chicago, Illinois 60064, USA
    Virology 225:282-92. 1996
    ..Thus, this system provided a rapid means to identify GBV-C E2 as a useful antigen for the study of GBV-C exposure...
  17. ncbi Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virus
    T J Tucker
    Department of Medical Microbiology SAIMR, University of Cape Town, Observatory, Cape Town, South Africa
    J Med Virol 61:52-8. 2000
    ..This preliminary study concludes that GBV-C/HGV is a lymphotropic virus that replicates primarily in the spleen and bone marrow...
  18. ncbi Phylogenetic analysis of GBV-C/hepatitis G virus
    D B Smith
    Department of Medical Microbiology, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Gen Virol 81:769-80. 2000
    ..The geographical distribution of virus variants is consistent with a long evolutionary history that may parallel that of pre-historic human migrations, implying that the long-term evolution of this RNA virus is extremely slow...
  19. ncbi Conserved RNA secondary structures in Flaviviridae genomes
    Caroline Thurner
    Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universitat Wien, Wahringerstrasse 17, A 1090 Wien, Austria
    J Gen Virol 85:1113-24. 2004
    ..computational survey of evolutionarily conserved secondary structure motifs in the genomic RNAs of the family Flaviviridae: This virus family consists of the three genera Flavivirus, Pestivirus and Hepacivirus and the group of GB ..
  20. ncbi Generation of infectious and transmissible virions from a GB virus B full-length consensus clone in tamarins
    A Sbardellati
    Istituto di Ricerche di Biologia Molecolare P. Angeletti (IRBM, Via Pontina Km 30.600, 00040 Pomezia (Roma, Italy
    J Gen Virol 82:2437-48. 2001
    ..Host humoral immune response to GBV-B antigens was also monitored. The progression of the disease was compared to that induced by intravenous injection of different amounts of the non-recombinant virus...
  21. ncbi RNA-dependent RNA polymerases from Flaviviridae
    Kyung H Choi
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch at Galveston, TX 77555 0647, USA
    Curr Opin Struct Biol 19:746-51. 2009
    Viral genome replication in Flaviviridae is carried out by a virally encoded RNA-dependent RNA polymerase (RdRp)...
  22. ncbi The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins
    R Graham Hope
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR and School of Applied Sciences, University of Glamorgan, Trefforrest, Cardiff CF37 1DL, United Kingdom
    J Biol Chem 277:4261-70. 2002
    ..These studies identify common features in disparate proteins that are required for lipid droplet localization...
  23. ncbi Viral hepatitis and primates: historical and molecular analysis of human and nonhuman primate hepatitis A, B, and the GB-related viruses
    B H Robertson
    Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
    J Viral Hepat 8:233-42. 2001
    ..This review summarizes the historical and molecular information for each of these groups and highlights the impact of these nonhuman primate hepatitis viruses on our understanding of the evolution of each of these viruses...
  24. ncbi GB virus B as a model for hepatitis C virus
    B Beames
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research and Southwest Regional Primate Research Center, San Antonio, Texas, USA
    ILAR J 42:152-60. 2001
    GB viruses A and B (GBV-A and GBV-B) are members of the Flaviviridae family and are isolated from tamarins injected with serum from a human hepatitis patient...
  25. pmc Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes
    R E Lanford
    Department of Virology and Immunology, Southwest Regional Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 75:8074-81. 2001
    ....
  26. ncbi Serological and histological findings in infection and transmission of GBV-C/HGV to macaques
    Y Cheng
    Department of Immunology, Institute of Infectious Diseases, Beijing, P R China
    J Med Virol 60:28-33. 2000
    ..It is possible that this virus is a mild and self-limited pathogenic agent to the hepatic cells of primates...
  27. ncbi Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae
    Maria Bretner
    Institut Biochemii i Biofizyki, Polska Akademia Nauk, Warszawa, Poland
    Antivir Chem Chemother 16:315-26. 2005
    ..their N-alkyl derivatives were synthesized and tested for antihelicase activity against enzymes of selected Flaviviridae including hepatitis C virus (HCV), West Nile virus (WNV), Dengue virus (DENV) and Japanese encephalitis virus (..
  28. ncbi Homologous recombination in GB virus C/hepatitis G virus
    M Worobey
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, England
    Mol Biol Evol 18:254-61. 2001
    ..The wide-ranging implications of such nonclonal history for reconstructing the spread and timescale of GBV-C evolution are discussed...
  29. ncbi Genomic analysis of two GB virus A variants isolated from captive monkeys
    J C Erker
    Virus Discovery Group, Experimental Biology Research, Abbott Laboratories, North Chicago, IL 60064, USA
    J Gen Virol 79:41-5. 1998
    ..Although the GBV-A variant polyproteins possess many motifs conserved between other members of the Flaviviridae, they do not encode a basic core-like protein...
  30. ncbi Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent
    J Bukh
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892 0740, USA
    Virology 262:470-8. 1999
    GB virus-B (GBV-B) is a member of the Flaviviridae family of viruses. This RNA virus infects tamarins, but its natural host is not known...
  31. ncbi A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission
    S Cook
    Department of Zoology, University of Oxford, Oxford, UK
    Arch Virol 151:309-25. 2006
    The genus Flavivirus (family Flaviviridae) presently comprises around 70 single-strand positive-sense RNA viruses...
  32. pmc Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold
    Alexander E Aleshin
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Protein Sci 16:795-806. 2007
    ..flaviviral proteases with the more distantly related Hepatitis C virus, we provide insights into the evolution of the Flaviviridae fold. Our work should expedite the design of protease inhibitors to treat a range of flaviviral infections.
  33. ncbi Structural and functional comparison of the non-structural protein 4B in flaviviridae
    Christoph Welsch
    Internal Medicine II, Saarland University Hospital, Kirrberger Strasse, 66421 Homburg Saar, Germany
    J Mol Graph Model 26:546-57. 2007
    b>Flaviviridae are evolutionarily related viruses, comprising the hepatitis C virus (HCV), with the non-structural protein 4B (NS4B) as one of the least characterized proteins...
  34. ncbi The sequence and genomic organization of a GB virus A variant isolated from captive tamarins
    T P Leary
    Virus Discovery Group, Abbott Laboratories, Dept, North Chicago, IL 60064, USA
    J Gen Virol 78:2307-13. 1997
    ..Phylogenetic analysis of the polyprotein confirms previous results that GBV-Alab is a member of the Flaviviridae, distinct from GBV-B and HCV, though more closely related to GBV-A and GBV-C.
  35. pmc RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae
    Roland Ivanyi-Nagy
    LaboRetro INSERM 758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, 69364 Lyon Cedex 07, France
    Nucleic Acids Res 36:712-25. 2008
    ..We now examined the RNA chaperone activity and the disordered nature of core proteins from different Flaviviridae genera, namely that of HCV, GBV-B (GB virus B), WNV (West Nile virus) and BVDV (bovine viral diarrhoea virus)...
  36. ncbi Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts
    R N Charrel
    Laboratoire de Virologie Moleculaire, Transfusionnelle et Tropicale, Faculte de Medecine, Marseille, France
    J Gen Virol 80:2329-35. 1999
    ....
  37. ncbi The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro
    S Steffens
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat Giessen, Germany
    J Gen Virol 80:2583-90. 1999
    ..is required for replication of the positive-strand RNA genome, is a key enzyme of members of the virus family Flaviviridae. By using heterologously expressed proteins, we demonstrate that the 77 kDa NS5B protein of two pestiviruses, ..
  38. ncbi Isolation of a new flavivirus related to cell fusing agent virus (CFAV) from field-collected flood-water Aedes mosquitoes sampled from a dambo in central Kenya
    R C Sang
    Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya
    Arch Virol 148:1085-93. 2003
    ..insect virus that was isolated from a line of Aedes aegypti mosquito cells and has been assigned to the family Flaviviridae, genus Flavivirus. We report here the first isolation of a CFA-like virus from field-collected mosquitoes...
  39. ncbi NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme
    Peter Borowski
    Abteilung fur Virologie, Bernhard Nocht Institut fur Tropenmedizin, Hamburg, Germany
    Acta Biochim Pol 49:597-614. 2002
    ..a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family...
  40. ncbi Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus
    Ning Zhang
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    J Med Chem 46:4149-64. 2003
    ..ring systems (30b, 30c, 32, and 34), have been synthesized as potential inhibitors of NTPases/helicases of Flaviviridae, including the West Nile virus (WNV), hepatitis C virus (HCV), and Japanese encephalitis virus (JEV)...
  41. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  42. ncbi Broad-spectrum inhibitor of viruses in the Flaviviridae family
    Joshua O Ojwang
    ZymeTx Inc, 655 Research Parkway, Suite 554 Oklahoma City, OK 73104, USA
    Antiviral Res 68:49-55. 2005
    The viruses in the Flaviviridae family have been associated with human and animal diseases...
  43. ncbi Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae
    Mauro Mazzei
    Department of Pharmaceutical Sciences, Viale Benedetto XV, 3, 16132 Genova, Italy
    Bioorg Med Chem 16:2591-605. 2008
    ..This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV)...
  44. pmc An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside
    Ravi K Ujjinamatada
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem Lett 17:2285-8. 2007
    ..Compound 4 was evaluated in vitro against NTPases/helicases of four different viruses of the Flaviviridae family, including the West Nile virus (WNV), hepatitis C virus (HCV), dengue virus (DENV), and the Japanese ..
  45. ncbi Early acquisition of TT virus in infants: possible minor role of maternal transmission
    Ho Hsiung Lin
    Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan
    J Med Virol 66:285-90. 2002
    ..In conclusion, TTV viremia is common in pregnant Taiwanese women and their infants. However, the results suggest that maternal transmission may play only a minor role in early acquisition of TTV in infants...
  46. ncbi Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases
    Barbara Selisko
    Centre National de la Recherche Scientifique and Universités d Aix Marseille I et II, UMR 6098, Architecture et Fonction des Macromolecules Biologiques, AFMB CNRS ESIL, 13288 Marseille Cedex 9, France
    Virology 351:145-58. 2006
    ..In contrast to the RdRps of hepaci- and pestiviruses, which belong to the same family of Flaviviridae, NS5 carries two activities, a methyltransferase (MTase) and a RdRp...
  47. ncbi GB virus C and TT virus infections in Japanese patients with autoimmune hepatitis
    Shuhei Nishiguchi
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    J Med Virol 66:258-62. 2002
    ..These findings provide no compelling evidence that GBV-C or TTV has a pathogenic role in autoimmune hepatitis...
  48. ncbi Prevalence of GB virus C (hepatitis G virus) and risk factors for infection in São Paulo, Brazil
    G Ribeiro-dos-Santos
    Fundação Pró Sangue Hemocentro de São Paulo, Avenida Dr Enéas de Carvalho Aguiar 155 1 Andar, 05403 000 Sao Paulo, Brazil
    Eur J Clin Microbiol Infect Dis 21:438-43. 2002
    ..5; 95%CI 1.2-5.4) were independently associated with GBV-C infection. In conclusion, the prevalence of GBV-C infection is high in São Paulo. In addition to parenteral transmission, another route, e.g. sexual or vertical, may be involved...
  49. ncbi [Virus isolated in the human blood leukocyte culture and its interaction with hepatitis C and G viruses]
    I F Barinskii
    Vopr Virusol 48:30-5. 2003
    ..Therefore, the HLV was described as belonging to the Flaviviridae family...
  50. ncbi [Replication strategies of the Flaviviridae family]
    Luminiţa Popa
    I N C D M I Cantacuzino, Bucuresti
    Bacteriol Virusol Parazitol Epidemiol 48:75-92. 2003
  51. ncbi Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses
    Maria Bretner
    Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
    Antivir Chem Chemother 15:35-42. 2004
    ..The above derivatives were tested as inhibitors of nucleoside triphosphatase (NTPase)/helicase activities of Flaviviridae: hepatitis C virus (HCV), West Nile virus (WNV), Japanese encephalitis virus (JEV) and dengue virus (DENV) and ..
  52. ncbi Expectoration of Flaviviruses during sugar feeding by mosquitoes (Diptera: Culicidae)
    Andrew F van den Hurk
    Virology, Queensland Health Scientific Services, Coopers Plains, Australia, 4108
    J Med Entomol 44:845-50. 2007
    ..Skuse and Culex gelidus Theobald (Diptera: Culicidae) were orally infected with Japanese encephalitis (family Flaviviridae, genus Flavivirus, JEV), Kunjin (family Flaviviridae, genus Flavivirus, KUNV; a subtype of West Nile virus), ..
  53. ncbi [Haemorrhagic fever viruses, possible bioterrorist use]
    Sophie Rigaudeau
    Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Presse Med 34:169-76. 2005
    ..These viruses belong to one of the following families: filoviridae, arenaviridae, bunyaviridae, and flaviviridae. They must be considered as dangerous biological weapons that could potentially be used...
  54. ncbi [The use of monoclonal antibodies in studying the causative agents of viral hemorrhagic fevers]
    G V Borisevich
    Vopr Virusol 48:4-8. 2003
    ..The methodological specificity of obtaining the Mabs to viral hemorrhagic-fevers' agents as well as data on its practical use are discussed...
  55. ncbi The role of reverse genetics systems in studying viral hemorrhagic fevers
    Hideki Ebihara
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Thromb Haemost 94:240-53. 2005
    ..Here we review the existing reverse genetics systems for VHF causing viruses and discuss their use in studying viral replication, pathogenesis, and the development of antivirals and vaccines...
  56. ncbi [OAS genes and susceptibility to West Nile virus]
    Jean Louis Guenet
    Med Sci (Paris) 19:9-12. 2003
  57. ncbi [Dengue and other hemorrhagic viral fevers]
    Cristina Domingo-Carrasco
    Laboratorio de Arbovirus y Enfermedades Víricas Importadas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Enferm Infecc Microbiol Clin 23:615-26. 2005
    ..Even today many factors related to origin, pathogenesis, treatment and control of these diseases remain uncertain...
  58. ncbi Detection of the negative-strand hepatitis C virus RNA in tissues: implications for pathogenesis
    R Quadri
    Division of Gastroenterology and Hepatology, University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
    Antiviral Res 52:161-71. 2001
    ..This is based on the comparison with the replication of other members of the Flaviviridae family...
  59. ncbi Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses
    Maria Bretner
    Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawińskiego Str, 02 106 Warszawa, Poland
    Acta Pol Pharm 61:26-8. 2004
    ..The N-alkyl derivatives showed good activity and lower cytotoxicity than TBBT...
  60. ncbi Prevalence of hepatitis B, hepatitis C, GB virus C/hepatitis G and TT viruses in predialysis and hemodialysis patients
    J M Lopez-Alcorocho
    Department of Hepatology, Fundación Jiménez Díaz and Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 63:103-7. 2001
    ..In conclusion, the prevalence of the viruses studied in predialysis may influence their prevalence in dialysis units...
  61. ncbi Evolutionarily conserved RNA secondary structures in coding and non-coding sequences at the 3' end of the hepatitis G virus/GB-virus C genome
    N M Cuceanu
    Laboratory for Clinical and Molecular Virology, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Gen Virol 82:713-22. 2001
    ..The prediction of similar structures in the same region of hepatitis C virus may allow the functions of these structures to be determined with a more tractable experimental model...
  62. pmc Molecular characteristic-based epidemiology of hepatitis B, C, and E viruses and GB virus C/hepatitis G virus in Myanmar
    K Nakai
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 39:1536-9. 2001
    ..These results suggest that these hepatitis virus infections are widespread in Myanmar and have led to a high incidence of acute and chronic liver disease patients in the region...
  63. pmc The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs
    R Rijnbrand
    Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 77555-1019, USA
    RNA 7:585-97. 2001
    ....
  64. ncbi TTV infection and its relation to serum transaminases in apparently healthy blood donors and in patients with clotting disorders who have been investigated previously for hepatitis C virus and GBV-C/HGV infection in Belgium
    Soegianto Ali
    Division of Liver and Pancreatic Diseases, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Med Virol 66:561-6. 2002
    ..TTV does not cause liver disease or contribute to the severity of liver disease...
  65. ncbi Experimental Usutu virus infection of suckling mice causes neuronal and glial cell apoptosis and demyelination
    Herbert Weissenbock
    Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    Acta Neuropathol 108:453-60. 2004
    ..While neuronal apoptosis is a general aspect of flavivirus pathogenicity, demyelination seems to be a unique feature of USUV infection...
  66. ncbi Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases
    E M F Muri
    Instituto de Quimica, Universidade do Brasil, Cidade Universitaria, CT Bloco A, Rio de Janeiro, Brasil
    Amino Acids 28:413-9. 2005
    ..In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors...
  67. ncbi Hepatitis C virus: clades and properties
    Colin R Howard
    Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, London, UK
    J Gastroenterol Hepatol 17:S468-70. 2002
    Hepatitis C virus (HCV) is a member of the virus family Flaviviridae. At present HCV is classified into a discrete hepacivirus genus and is represented by six clades according to genome sequencing...
  68. ncbi Vaccines and animal models for arboviral encephalitides
    Aysegul Nalca
    Homeland Security and Infectious Disease Research Division, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antiviral Res 60:153-74. 2003
    ..The most significant arboviruses causing human illness belong to genera in three viral families, Togaviridae, Flaviviridae, and Bunyaviridae...
  69. ncbi 5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses
    M Bretner
    Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
    Nucleosides Nucleotides Nucleic Acids 22:1531-3. 2003
    ..Synthesis and interactions of guanosine, inosine and ribavirin 5'-fluorosulfonylbenzoyl esters with hepatitis C virus (HCV) and Flaviviruses NTPase/helicase and polymerase are described...
  70. ncbi Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A
    Tetsuo Yamashita
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Virology 373:426-36. 2008
    ..The detailed structural comparison among the viruses of the family Flaviviridae should help in clarifying the molecular mechanism of viral replication and in providing rationale for the ..
  71. ncbi Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI)
    Peter Borowski
    Department of Molecular Biology, Institute of Environmental Protection, John Paul II Catholic University of Lublin, Al Krasnicka 102, 20 718 Lublin, Poland
    Biochem Pharmacol 76:28-38. 2008
    The NTPase/helicase of Flaviviridae viruses is one of the essential components of their replication complex. The enzyme is defined by the presence of seven highly conserved amino acid motifs...
  72. ncbi Mutagenesis analysis of the NS2B determinants of the Alkhurma virus NS2B-NS3 protease activation
    Boris A M Pastorino
    Unité de Virologie Tropicale, Institut de Médecine Tropicale du Service de Santé des Armées IMTSSA, BP 46, 13998 Marseille Armees, France
    J Gen Virol 87:3279-83. 2006
    ..The results also determine residues in the ALKV NS2B cofactor essential for protease activation, giving new insights into protease function in flaviviruses...
  73. ncbi Assessment of substrate specificity of hepatitis G virus NS3 protease by a genetic method
    Y J Lee
    Department of Life Science and National Research Laboratory of Proteolysis, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju 500-712, Korea
    Biochem Biophys Res Commun 286:171-5. 2001
    ..Our result would provide an insight on the molecular activity of the NS3 protease and may be useful for the design of substrate-based inhibitors...
  74. ncbi Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease
    Aloke K Bera
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 282:12883-92. 2007
    ..Formation of an active protease was found to require neither cleavage of NS2B from NS3 nor a free NS3 N terminus. Evidence was also obtained for product inhibition of the protease by the cleaved C terminus of NS2B...
  75. ncbi Design, synthesis and anti flaviviridae activity of N(6)-, 5',3'-O- and 5',2'-O-substituted adenine nucleoside analogs
    Angela Angusti
    Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
    Chem Pharm Bull (Tokyo) 56:423-32. 2008
    ..libraries of nucleoside analogues we discovered that the adenine derivatives FEVB28 and FEG118 were Flaviviridae inhibitors endowed with potency comparable, if not superior, to that of ribavirin...
  76. pmc Cell clones selected from the Huh7 human hepatoma cell line support efficient replication of a subgenomic GB virus B replicon
    Amedeo De Tomassi
    Istituto di Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
    J Virol 76:7736-46. 2002
    ..The replication of GBV-B subgenomic RNA was susceptible to inhibition by known inhibitors of HCV to a level similar to that of HCV subgenomic RNA...
  77. ncbi Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins
    James R Jacob
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, NY 14853, USA
    J Microbiol 45:431-40. 2007
    ..1-DNJ, was demonstrated against bovine viral diarrhea virus (BVDV) and GB virus-B (GBV-B), both members of the Flaviviridae family, and against woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV), both members of the ..
  78. ncbi Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides
    A Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
    Med Chem 3:520-32. 2007
    ..e. Enterovirus Coxsackie B2 (CVB-2) and Polio (Sb-1)] and of two of the three genera of the Flaviviridae [Bovine Viral Diarrhea Virus (BVDV) and Yellow Fever Virus (YFV)]...
  79. ncbi West Nile virus vaccines
    Roy A Hall
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, Queensland 4072, Australia
    Expert Opin Biol Ther 4:1295-305. 2004
    ..Levels of efficacy and safety, as well as logistical, economic and environmental issues, must all be carefully considered before vaccine candidates are approved and selected for large-scale manufacture and distribution...
  80. ncbi Prevalence of a novel DNA virus (TTV) among patients on maintenance hemodialysis
    M Schroter
    Institut fur Medizinische Mikrobiologie und Immunologie, Universitats Krankenhaus Eppendorf, Hamburg, Deutschland
    Nephron 87:139-42. 2001
    ..A recently detected DNA virus (TTV) has been assumed to be responsible for posttransfusion hepatitis in humans. Until now it is unclear whether patients on maintenance hemodialysis are at increased risk of acquiring TTV...
  81. ncbi Old bugs and new: classical and emerging pathogens--relevance to dental practice
    Joan Power
    Munster Regional Transfusion Centre, St Finbarr s Hospital, Douglas, Cork
    J Ir Dent Assoc 50:79-80. 2004
  82. ncbi Effect of coinfection with GB virus C on survival among patients with HIV infection
    J Xiang
    Department of Internal Medicine and Research, Iowa City Veterans Affairs Medical Center, and the University of Iowa College of Medicine, USA
    N Engl J Med 345:707-14. 2001
    ..CONCLUSIONS: GBV-C infection is common in people with HIV infection and is associated with significantly improved survival...
  83. ncbi Reliable detection of St. Louis encephalitis virus by RT-nested PCR
    Viviana Re
    Instituto de Virologia Dr J M Vanella, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Enferm Infecc Microbiol Clin 26:10-5. 2008
    ..Herein, we report the development of a species-specific RT-nested PCR to detect SLEV...
  84. ncbi The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic area
    M L Yu
    Hepatobiliary Division, Department of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Infect 42:61-6. 2001
    ..HCV viraemia played the most important clinical hepatopathic role in the area. Infections with other hepatitis viruses did not influence the anti-E2 seroconversion from GBV-C/HGV infections...
  85. ncbi A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-derived zinc-chelating trioxa-adamantane-triol
    Andreas J Kesel
    Chammünsterstr 47, D 81827 München, Germany
    Bioorg Med Chem 11:4599-613. 2003
    ..wide RNA virus selection including Picornaviridae (poliovirus, human coxsackievirus, hepatitis A virus), Flaviviridae (yellow fever virus, Dengue virus, West Nile virus, Kunjin virus, St...
  86. pmc Persistent West Nile virus transmission and the apparent displacement St. Louis encephalitis virus in southeastern California, 2003-2006
    William K Reisen
    Arbovirus Research Unit, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Old Davis Rd, Davis, CA 95616, USA
    J Med Entomol 45:494-508. 2008
    West Nile virus (family Flaviviridae, genus Flavivirus, WNV) invaded the Colorado Desert biome of southern California during summer 2003 and seemed to displace previously endemic St...
  87. ncbi Tick-borne viruses
    M Labuda
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
    Parasitology 129:S221-45. 2004
    ..found in six different virus families (Asfarviridae, Reoviridae, Rhabdoviridae, Orthomyxoviridae, Bunyaviridae, Flaviviridae) and at least 9 genera...
  88. ncbi Arbovirus infections and viral haemorrhagic fevers in Uganda: a serological survey in Karamoja district, 1984
    F Rodhain
    Unité d Ecologie des Systèmes Vectoriels, Institut Pasteur, Paris, France
    Trans R Soc Trop Med Hyg 83:851-4. 1989
    ..Forest alphaviruses (Togaviridae); dengue type 2, Wesselsbron, West Nile, yellow fever and Zika flaviviruses (Flaviviridae); Bunyamwera, Ilesha and Tahyna bunyaviruses (Bunyaviridae); and Sicilian sandfly fever phlebovirus (..
  89. ncbi [Dengue fever: from disease to vaccination]
    R Teyssou
    Sanofi Pasteur Lyon, France
    Med Trop (Mars) 69:333-4. 2009
    ..Dengue iscaused by an arbovirus belonging to the Flavivirus genus of the family Flaviviridae. There are four dengue virus serotypes and no cross protection between them...
  90. ncbi Ability of transstadially infected Ixodes pacificus (Acari: Ixodidae) to transmit West Nile virus to song sparrows or western fence lizards
    W K Reisen
    Center for Vectorborne Diseases and Department of Pathology, Immunology, and Microbiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Med Entomol 44:320-7. 2007
    ..pacificus Cooley & Kohls (Acari: Ixodidae) may serve as a reservoir and vector of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) in California was tested by determining the ability of this tick species to become ..
  91. ncbi Epidemiology of hemorrhagic fever viruses
    J W LeDuc
    Disease Assessment Division, U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701 5001
    Rev Infect Dis 11:S730-5. 1989
    ..hemorrhagic fever, and Hantaan viruses; Filoviridae, which includes Marburg and Ebola viruses; and Flaviviridae, which includes yellow fever, dengue, Kyasanur Forest disease, and Omsk viruses...
  92. ncbi Microclimate and the zoonotic cycle of tick-borne encephalitis virus in Switzerland
    C Burri
    Institute of Biology, Laboratory of Eco Epidemiology of Parasites, University of Neuchatel, Emile Argand 11, 2000 Neuch and tel, Switzerland
    J Med Entomol 48:615-27. 2011
    The focal distribution of tick-borne encephalitis virus (TBEV; Flaviviridae, Flavivirus) appears to depend mainly on cofeeding transmission between infected Ixodes ricinus L. nymphs and uninfected larvae...
  93. pmc Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes
    C D Blair
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523 1677, USA
    Clin Microbiol Rev 13:651-61. 2000
    ..virus (LAC) (a member of the Bunyaviridae) and dengue viruses serotypes 1 to 4 (DEN-1 to DEN-4) (members of the Flaviviridae) were expressed in mosquito cells from double-subgenomic and replicon vectors based on Sindbis virus (a member ..
  94. ncbi [Tick-borne human pathogenic microorganisms found in Europe and those considered nonpathogenic. Part I: Ticks and Viruses]
    J Süss
    Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Standort Jena, Jena
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:392-404. 2004
    ..Among these ticks, viruses from 6 families encompassing 8 genera and 35 species are found,whereby the families Flaviviridae, Bunyaviridae, and Reoviridae with the genera flavivirus, nairovirus, and orbivirus are the most prevalent...
  95. ncbi Comparison of immune responses of brown-headed cowbird and related blackbirds to west Nile and other mosquito-borne encephalitis viruses
    William K Reisen
    Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Wildl Dis 43:439-49. 2007
    The rapid geographic spread of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) across the United States has stimulated interest in comparative host infection studies to delineate competent avian hosts critical for viral ..
  96. ncbi Evolutionary influences in arboviral disease
    S C Weaver
    Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Curr Top Microbiol Immunol 299:285-314. 2006
    ..which have probably limited the evolution of arboviruses to only a few families of RNA viruses (Togaviridae, Flaviviridae, Bunyaviridae, Rhabdoviridae, Reoviridae, and Orthomyxoviridae) and a single DNA virus...
  97. pmc Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles
    Anna K Overby
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D 79008 Freiburg, Germany
    J Virol 84:8470-83. 2010
    Tick-borne encephalitis virus (TBEV) (family Flaviviridae, genus Flavivirus) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia...
  98. pmc Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristics
    Alexander T Ciota
    The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA
    PLoS ONE 4:e7876. 2009
    St. Louis encephalitis virus (SLEV; Flaviviridae, flavivirus) was the major cause of epidemic flaviviral encephalitis in the U.S. prior to the introduction of West Nile virus (WNV) in 1999...
  99. ncbi Evidence for the presence of two novel pestivirus species
    R Avalos-Ramirez
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat, Giessen, D 35392, Germany
    Virology 286:456-65. 2001
    The genus Pestivirus of the family Flaviviridae comprises four species, namely Bovine viral diarrhea virus-1 (BVDV-1), BVDV-2, Border disease virus (BDV), and Classical swine fever virus (CSFV)...
  100. ncbi Insect-transmitted vertebrate viruses: flaviviridae
    G V Ludwig
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702
    In Vitro Cell Dev Biol Anim 29:296-309. 1993
    The Flaviviridae include almost 70 viruses, nearly half of which have been associated with human disease...
  101. pmc C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response
    Doug E Brackney
    Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    PLoS Negl Trop Dis 4:e856. 2010
    ..C6/36 and Drosophila melanogaster S2 cells were infected with WNV (Flaviviridae), Sindbis virus (SINV, Togaviridae) and La Crosse virus (LACV, Bunyaviridae) and total RNA recovered from cell ..

Research Grants62

  1. The effects of hepatitis C virus (HCV) E2 protein on host immunomodulation
    Jack T Stapleton; Fiscal Year: 2013
    ..Identification and characterization of this HCV E2 - lymphocyte interaction may contribute to the development of novel therapeutic and/or vaccine approaches to HCV, and potentially to related viruses within the Flaviviridae.
  2. Bioavailable proteasome inhibitors as broad-spectrum antivirals
    ALEXANDER NICLAS FREIBERG; Fiscal Year: 2013
    ..Category A-C pathogens: Filoviridae (Ebola), Paramyxoviridae (Nipah), Bunyaviridae (Rift Valley fever), Flaviviridae (Russian-Spring-Summer encephalitis), and Arenaviridae (Junin)...
  3. Deep Sequencing for the Detection of Viral Sequences in Primary Progressive Multi
    John D Kriesel; Fiscal Year: 2012
    ..These initial sequencing data have led to an intriguing candidate virus: GBV-C, a member of the Flaviviridae family never recovered before from a human brain...
  4. Dengue Virus Genome Encapsidation and Its Interplay with Host Lipid Droplets
    Andrea Gamarnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus, a member of the Flaviviridae family, is a Category A pathogen that causes the most prevalent arthropod-borne viral illnesses in humans...
  5. Mechanisms for cell uptake of LDL/DNA complexes
    NATALIA V GUEVARA; Fiscal Year: 2013
    ..as potential B/E receptor binding sites based on presence R/K-rich motifs similar to those in to apo E and in Flaviviridae proteins...
  6. Broad-spectrum, small-molecule inhibitors of bunyaviruses
    Robert D Allen; Fiscal Year: 2010
    ..activities that extend beyond the family Bunyaviridae against viruses in the Poxviridae, Togaviridae, and Flaviviridae families, presumably by targeting host pathways essential for replication of a diversity of virus families...
  7. Genetic viral and host adaptations to breach species barriers of HCV
    Alexander Ploss; Fiscal Year: 2013
    ..hepatitis C, which is caused by hepatitis C virus (HCV) - a positive sense, single-stranded RNA virus of the Flaviviridae family. HCV has a high propensity for establishing chronic infection...
  8. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..including Influenza A and B (Orthomyxoviridae), HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia (Poxviridae), VEE, an alphavirus (Togaviridae), and Tacaribe virus (..
  9. Host factor DNAJC14 as a novel target for broad spectrum anti-flavivirus activity
    Margaret R Macdonald; Fiscal Year: 2010
    ..inhibition may lead to strategies to prevent infection and/or disease caused by human pathogenic viruses in the Flaviviridae family...
  10. Genetic determinants of adaptation of two flaviviruses
    Laura D Kramer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The emergence and rapid biogeographic expansion of West Nile Virus (WNV;Flaviviridae;Flavivirus) throughout the western hemisphere, as well as the re-emergence of other medically significant viruses, ..
  11. A biomimetic nanoparticle protease assay platform
    Steven W Graves; Fiscal Year: 2013
    ..cleave protein targets (substrates) important in the progression of disease, like viral processing by the flaviviridae, toxin cleavage of proteins, and digestion of the extracellular matrix during cancer metastasis...
  12. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
    DESCRIPTION (adapted from the applicant's abstract): Dengue viruses, members of the Flaviviridae are recognized as the causative agent or one of the most important mosquito-borne viral diseases of humans affecting 100 million people ..
  13. ANTIVIRAL DRUG DELIVERY WITH LYOPHILIZED PLATELETS
    Thomas Fischer; Fiscal Year: 2004
    ..Lassa fever virus), Filoviridae (e.g., Ebola and Marburg viruses), Bunyaviridae (e.g., Rift Valley virus) and Flaviviridae (e.g...
  14. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    Dengue viruses, members of Flaviviridae, are recognized as the causative agent of mosquito borne viral diseases affecting about 100 million people annually...
  15. Automated Simultaneous Detection of Bioterrorism Agents
    David Ecker; Fiscal Year: 2005
    ..development and validation for NIAID/CDC-priority pathogens such as the Poxviridae, Arenaviridae, Bunyaviridae, Flaviviridae, Togaviridae (especially VEE), and Filoviridea families and the alpha, beta, gamma-proteobacteria...
  16. Antiviral agents for Flavivirus infections of bioterror
    Timothy Block; Fiscal Year: 2003
    ..and develop a new class of antiviral compounds, we call "glucovirs", for the treatment of members of the flaviviridae family such as West Nile Encephalitis Virus, Yellow Fever (WNEV, YFV respectively) and Powassan viruses (PV) ..
  17. Latin America Workshop On Denge
    Jorge Osorio; Fiscal Year: 2009
    ..provided by applicant): Dengue viruses (DENV) include four serotypes (DENV-1 - DENV-4) that belong to the Flaviviridae family and cause the most important arthropod-borne viral infection of humans with about 100 million cases and ..
  18. Screening for antivirals against flaviviruses
    PAUL OLIVO; Fiscal Year: 2003
    ..Some VHF agents have been suspect for abuse in biowarfare/bioterrorism. Members of the family Flaviviridae are among the viral agents that cause VHF...
  19. Chimeric hepatitis C vaccine vector
    JACK NUNBERG; Fiscal Year: 2004
    ..HCV is an enveloped RNA virus in the Flaviviridae family, which also includes the Flavivirus and Pestivirus genera...
  20. DENGUE CONTROL IN MOSQUITOES BY SINGLE CHAIN ANTIBODIES
    KENNETH OLSON; Fiscal Year: 1999
    ..The lack of effective vaccines against DEN viruses (serotypes 1-4; Flaviviridae), the collapse of mosquito control programs in many developing countries, and the emergence of pesticide ..
  21. Intracellular Assembly of the Coronavirus, IBV
    Carolyn Machamer; Fiscal Year: 2005
    ..These include Bun yaviridae and Flaviviridae. The long term goals of the proposed experiments are to elucidate the mechanism and advantages of intracellular ..
  22. Functional Analysis of HCV-B Lymphocyte Interactions
    Thomas Chambers; Fiscal Year: 2003
    The hepatitis C viruses (HCV) are small RNA viruses within the family Flaviviridae, distinguished from other members by their capacity to cause persistent infection in humans with serious consequences such as chronic active hepatitis, ..
  23. HEPATITIS C VIRUS AND HEPATOCELLULAR CARCINOMA A
    Srikanta Dash; Fiscal Year: 2000
    ..Hepatitis C virus (HCV), a small positive-sense RNA virus of the Flaviviridae family, is the major cause of hepatitis in the United States and often leads to chronic hepatitis, cirrhosis ..
  24. Effect of Thiopurines on RNA Viruses/Hepatitis C Virus
    Robert Striker; Fiscal Year: 2005
    Viruses from the Family Flaviviridae, including West Nile Virus, Dengue Virus and Hepatitis C Virus (HCV), are significant causes of morbidity and mortality, yet have few to no treatment options...
  25. Replication Elements in the 5' End of the HCV Genome
    Minkyung Yi; Fiscal Year: 2004
    Hepatitic C virus (HCV) is the single member of the genus hepacivirus in the family Flaviviridae. The genome consists of a single positive-stranded RNA molecule...
  26. Immunogenicity of Hepatitis C Virus (HCV) like particles
    Glen Barber; Fiscal Year: 2007
    Hepatitis C virus [HCV], a member of the Flaviviridae, is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma...
  27. RNA-Protein Interactions in the Flaviviridae viruses.
    RAUL GOMILA; Fiscal Year: 2003
    ..Therefore, the elucidation of the molecular mechanism of interaction between the RNA and proteins of these viruses could be important in order to design effective antiviral therapies. ..
  28. Small Molecules as Research Tools for HCV Biology
    Charles Rice; Fiscal Year: 2004
    ..Inhibitory, non-cytotoxic compounds will be counter-screened against other members of the Flaviviridae family, including bovine viral diarrhea virus and yellow fever virus...
  29. Developing antiviral agents that inhibit HCV translation
    ZHENGXIAN GU; Fiscal Year: 2005
    ..Thus, it is necessary to develop new anti-HCV drugs. HCV is a member of the family Flaviviridae. The HCV genome contains a long, single open reading frame mRNA that encodes the viral proteins...
  30. Defining NS4B Function in Hepatitis C Virus Replication
    Keril J Blight; Fiscal Year: 2010
    ..whose function in HCV replication is the least understood not only in HCV, but also in other members of the Flaviviridae family...
  31. Developing antiviral agents that inhibit HCV translation
    ZHENGXIAN GU; Fiscal Year: 2003
    ..Thus, it is necessary to develop new anti-HCV drugs. The HCV is a member of the family Flaviviridae. The HCV genome contains a long, single open reading frame mRNA that encodes the viral proteins...
  32. ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDS
    William Reisen; Fiscal Year: 2002
    ..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..
  33. HOST COMPETENCE FACTORS AFFECT ARBOVIRUS TRANSMISSION
    William Reisen; Fiscal Year: 2003
    ..Studies will assess how alternating sequential infections between vertebrate and vector species that are part of the natural transmission cycle may alter virus genetics and fitness. ..
  34. Trafficking, persistence and evolution of HIV in the CNS
    Peter Simmonds; Fiscal Year: 2005
    ....
  35. HIV-1 Tat modulation of HCV replication and pathogenesis
    Robert Garry; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  36. Peptide drugs against influenza virus
    Robert Garry; Fiscal Year: 2007
    ..The studies proposed in this application will address an urgent public health and biodefense need for new drugs that are effective against influenza viruses. [unreadable] [unreadable]..
  37. Rapid screen for Ebola virus membrane interactions/drugs
    Robert Garry; Fiscal Year: 2005
    ....
  38. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  39. Recombinant antigen assays for Lassa and other arenaviru
    Robert Garry; Fiscal Year: 2005
    ....
  40. Rapid screen for HIV TM membrane interactions/drugs
    Robert Garry; Fiscal Year: 2004
    ..The approaches piloted here may be useful for developing drugs against the AIDS virus and a broad range of important human viral pathogens with similar fusion proteins. ..
  41. Structure and size determination of S. aureus pathogenicity island capsids
    Terje Dokland; Fiscal Year: 2008
    ..The bacteriophage/pathogenicity island system is of special interest for its role in transferring toxin genes and conferring pathogenicity on non-pathogenic strains. [unreadable] [unreadable] [unreadable]..
  42. INITIATION OF HEPATITIS C VIRUS TRANSLATION
    CHRISTOPHER HELLEN; Fiscal Year: 2001
    ..abstract_text> ..
  43. HCV-ALCOHOL INTERACTIONS-- PATHOGENESIS AND EPIDEMIOLOGY
    Jack Stapleton; Fiscal Year: 2001
    ..These studies may lead to insights on the mechanism of liver injury and help define those patients who are most likely to have progressive liver injury. ..
  44. HEPATITIS C VIRUS IN ETIOLOGY OF WA RHEUMATOID FACTORS
    Vincent Agnello; Fiscal Year: 2001
    ..We have also established that the LDL receptor mediates endocytosis of HCV and other members of the Flaviviridae family and that the apolipoprotein E epsilon2 allele in HCV infected patients increases the risk of developing ..
  45. LIVE, ATTENUATED, RECOMBINANT VACCINE - WEST NILE VIRUS
    Thomas Monath; Fiscal Year: 2002
    ..abstract_text> ..
  46. Functional analysis of flavivirus genetic resistance.
    Margo A Brinton; Fiscal Year: 2010
    ..This research is relevant to understanding individual variation in the response to flavivirus infections among humans. ..
  47. MOLECULAR GENETIC MARKERS FOR TICK VECTORS
    HARRY HUTCHESON; Fiscal Year: 2002
    ..I.) pacificus and I. (Ixodiopsis) woodi using 3 B. burgdorferi strains from the northeastern, southeastern, and western regions of the USA. ..
  48. Development of Inhibitors Against HCV Infection
    Joshua Ojwang; Fiscal Year: 2002
    ..abstract_text> ..
  49. Development of a new model of viral hemorrhagic fever.
    MARGO BRINTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. Arbovirus quasispecies-impact of arthropod transmission
    GREGORY EBEL; Fiscal Year: 2004
    ..abstract_text> ..
  51. Molcular detection of weaponized arenaviruses
    Remi Charrel; Fiscal Year: 2003
    ..The ultimate goal is to propose a ready-to-use diagnostic kit for the detection and characterization of weaponized arenaviruses. ..
  52. Oas-1 gene transgenic mice for WNV research.
    MARGO BRINTON; Fiscal Year: 2005
    ....
  53. INTERFERON IN MODULATING DENGUE VIRUS INFECTION
    Michael Diamond; Fiscal Year: 2002
    ....
  54. West Nile Virus Genotypic Affect on Host Competence
    AARON BRAULT; Fiscal Year: 2006
    ..abstract_text> ..
  55. Immunotherapy of hepatitis C virus infection.
    Eric Gowans; Fiscal Year: 2006
    ..The effect on the viral load in the liver disease will be measured by quantitative RT-PCR and ALT levels, respectively, and correlated with the markers of the cellular immune response described above. [unreadable] [unreadable]..
  56. Ethnobotanical Anti-Respiratory Syncytial Virus Drugs
    Joshua Ojwang; Fiscal Year: 2003
    ..proposed commercial application: not available ..
  57. West Nile Viral Determinants of Avian Pathogenesis
    AARON BRAULT; Fiscal Year: 2007
    ..In addition, fundamental knowledge of viral replication and pathogenesis will provide insight for the development of vaccine and antiviral strategies. [unreadable] [unreadable]..
  58. Lamin A Mutation and Hutchinson-Gilford Progeria
    Howard Worman; Fiscal Year: 2008
    ..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
  59. Lamin A in Adipocyte Differentation and Survival
    Howard Worman; Fiscal Year: 2004
    ..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..