japanese encephalitis virus

Summary

Summary: A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.

Top Publications

  1. ncbi Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus
    Soma Das
    Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Virology 385:47-57. 2009
  2. pmc The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells
    Yi Lin Chan
    Graduate Institute of Life Sciences, National Defense Medical Center, Institute of Biomedical Sciences, Taipei, Taiwan, Republic of China
    J Virol 82:10455-64. 2008
  3. ncbi Ecology and geographical expansion of Japanese encephalitis virus
    Andrew F van den Hurk
    Virology, Queensland Health Forensic and Scientific Services, Archerfield, Queensland 4108, Australia
    Annu Rev Entomol 54:17-35. 2009
  4. ncbi Complete nucleotide sequence of the Japanese encephalitis virus genome RNA
    H Sumiyoshi
    Department of Preventive Medicine, Nagasaki University, Japan
    Virology 161:497-510. 1987
  5. ncbi Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir
    Thananya Thongtan
    Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand
    Microbes Infect 12:37-45. 2010
  6. pmc Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 80:5908-18. 2006
  7. ncbi Evaluation of IgM antibody capture enzyme-linked immunosorbent assay kits for detection of IgM against Japanese encephalitis virus in cerebrospinal fluid samples
    Vasanthapuram Ravi
    Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Am J Trop Med Hyg 81:1144-50. 2009
  8. pmc Development and application of a reverse genetics system for Japanese encephalitis virus
    Sang Im Yun
    Department of Internal Medicine, Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea
    J Virol 77:6450-65. 2003
  9. pmc Development and evaluation of reverse transcription-loop-mediated isothermal amplification assay for rapid and real-time detection of Japanese encephalitis virus
    M M Parida
    Division of Virology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh 474002, India
    J Clin Microbiol 44:4172-8. 2006
  10. ncbi A serological survey of pigs, horses, and ducks in Nepal for evidence of infection with Japanese encephalitis virus
    Ganesh R Pant
    Central Veterinary Laboratory, Tripureshwor, Kathmandu, Nepal
    Ann N Y Acad Sci 1081:124-9. 2006

Detail Information

Publications249 found, 100 shown here

  1. ncbi Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus
    Soma Das
    Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Virology 385:47-57. 2009
    b>Japanese encephalitis virus (JEV) envelope (E) protein has been shown to play a critical role in attachment to cells. However, the receptor interacting with envelope protein has not been conclusively identified...
  2. pmc The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells
    Yi Lin Chan
    Graduate Institute of Life Sciences, National Defense Medical Center, Institute of Biomedical Sciences, Taipei, Taiwan, Republic of China
    J Virol 82:10455-64. 2008
    ..In this study, we found that viperin is highly induced at the RNA level by Japanese encephalitis virus (JEV) and Sindbis virus (SIN) and that viperin protein is degraded in JEV-infected cells through a ..
  3. ncbi Ecology and geographical expansion of Japanese encephalitis virus
    Andrew F van den Hurk
    Virology, Queensland Health Forensic and Scientific Services, Archerfield, Queensland 4108, Australia
    Annu Rev Entomol 54:17-35. 2009
    b>Japanese encephalitis virus (JEV) (Flavivirus: Flaviviridae) is a leading cause of encephalitis in eastern and southern Asia. The virus is maintained in a zoonotic cycle between ardeid wading birds and/or pigs and Culex mosquitoes...
  4. ncbi Complete nucleotide sequence of the Japanese encephalitis virus genome RNA
    H Sumiyoshi
    Department of Preventive Medicine, Nagasaki University, Japan
    Virology 161:497-510. 1987
    The complete nucleotide sequence of the Japanese encephalitis virus (JEV) genome RNA was determined...
  5. ncbi Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir
    Thananya Thongtan
    Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand
    Microbes Infect 12:37-45. 2010
    b>Japanese encephalitis virus (JEV), a mosquito-borne Flavivirus, is a major cause of acute encephalitis, and neurons have been proposed to be the principle JEV target cells in the central nervous system...
  6. pmc Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 80:5908-18. 2006
    b>Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes severe human disease, has been shown to block the interferon (IFN)-induced Janus kinase signal transducer and activation of transcription (Jak-Stat) signaling ..
  7. ncbi Evaluation of IgM antibody capture enzyme-linked immunosorbent assay kits for detection of IgM against Japanese encephalitis virus in cerebrospinal fluid samples
    Vasanthapuram Ravi
    Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Am J Trop Med Hyg 81:1144-50. 2009
    Infection with Japanese encephalitis virus (JEV) is a major public health problem in Asia...
  8. pmc Development and application of a reverse genetics system for Japanese encephalitis virus
    Sang Im Yun
    Department of Internal Medicine, Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea
    J Virol 77:6450-65. 2003
    b>Japanese encephalitis virus (JEV) is a common agent of viral encephalitis that causes high mortality and morbidity among children...
  9. pmc Development and evaluation of reverse transcription-loop-mediated isothermal amplification assay for rapid and real-time detection of Japanese encephalitis virus
    M M Parida
    Division of Virology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh 474002, India
    J Clin Microbiol 44:4172-8. 2006
    ..isothermal amplification (RT-LAMP) assay is reported for rapid and real-time detection of Japanese encephalitis virus (JEV)...
  10. ncbi A serological survey of pigs, horses, and ducks in Nepal for evidence of infection with Japanese encephalitis virus
    Ganesh R Pant
    Central Veterinary Laboratory, Tripureshwor, Kathmandu, Nepal
    Ann N Y Acad Sci 1081:124-9. 2006
    ..92% were found positive for the presence of antibodies against JE virus infection in Nepal. Sero-prevalence of JE in pigs, ducks, and horses was 48.11%, 26.79%, and 50.0%, respectively...
  11. ncbi Entry into and production of the Japanese encephalitis virus from C6/36 cells
    Verawan Boonsanay
    Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Nakorn Pathom, Thailand
    Intervirology 50:85-92. 2007
    The mosquito-borne Japanese encephalitis virus is a leading cause of encephalitis worldwide...
  12. ncbi Cross-reactivity of Japanese encephalitis virus-vaccinated horse sera in serodiagnosis of West Nile virus
    Jiro Hirota
    Research Team for Advanced Biologicals, National Institute of Animal Health, National Agriculture and Food Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 72:369-72. 2010
    ..b>Japanese encephalitis virus (JEV) is endemic in Asia and, in Japan, many horses are vaccinated against JEV...
  13. pmc Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005
    Seok Min Yun
    WHO Japanese Encephalitis Regional Reference Laboratory for the Western Pacific Region Division of Arboviruses, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea
    Virol J 7:127. 2010
    We sequenced the envelope (E) gene of 17 strains of the Japanese encephalitis virus (JEV) isolated in South Korea in 1983-2005 and compared the sequences with those from previously reported strains...
  14. ncbi New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting, Bangkok, Thailand, 13-15 October 1998
    T F Tsai
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Fort Collins, CO 80522, USA
    Vaccine 18:1-25. 2000
    ..The minutes and recommendations of a meeting of experts to discuss these issues, jointly sponsored by the World Health Organization and the Children's Vaccine Initiative in Bangkok, Thailand, 13-15 October, 1998, are presented...
  15. ncbi Japanese encephalitis virus: ecology and epidemiology
    T P Endy
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences USAMC AFRIMS, 315 6 Rajvithi Road, Bangkok 10400, Thailand
    Curr Top Microbiol Immunol 267:11-48. 2002
  16. pmc Japanese encephalitis virus induce immuno-competency in neural stem/progenitor cells
    Sulagna Das
    National Brain Research Centre, Manesar, Haryana, India
    PLoS ONE 4:e8134. 2009
    ..Since NSPCs are the cellular targets in a number of virus infections both during postnatal and adult stages, we wanted to investigate the immunological properties of these stem cells in response to viral pathogen...
  17. pmc NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness
    Ezequiel Balmori Melian
    Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    J Virol 84:1641-7. 2010
    ..a larger NS1-related protein, NS1', is often detected during infection with the members of the Japanese encephalitis virus serogroup of flaviviruses...
  18. ncbi Sensitive and specific detection of strains of Japanese encephalitis virus using a one-step TaqMan RT-PCR technique
    Jau Ling Huang
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Med Virol 74:589-96. 2004
    A rapid, sensitive, and accurate laboratory diagnostic test is needed for distinguishing Japanese encephalitis virus (JEV) from other diseases featuring similar clinical symptoms and also for preventing potential outbreaks...
  19. pmc Origin and evolution of Japanese encephalitis virus in southeast Asia
    Tom Solomon
    Department of Neurological Science, University of Liverpool, Liverpool L9 7LJ, United Kingdom
    J Virol 77:3091-8. 2003
    ..Four genotypes of Japanese encephalitis virus (JEV) are presently recognized (representatives of genotypes I to III have been fully sequenced), but ..
  20. ncbi Control of Japanese encephalitis--within our grasp?
    Tom Solomon
    United Kingdom Medical Research Council, United Kingdom
    N Engl J Med 355:869-71. 2006
  21. ncbi Rapid detection and quantification of Japanese encephalitis virus by real-time reverse transcription loop-mediated isothermal amplification
    Hiroko Toriniwa
    Department of Research and Development, Research Center for Biologicals, The Kitasato Institute, Kitamoto, Saitama 364 0026, Japan
    Microbiol Immunol 50:379-87. 2006
    ..transcription loop-mediated isothermal amplification (RT-LAMP) assay targeting the envelope gene of Japanese encephalitis virus. The RT-LAMP enabled us to detect the target product within 1 hr by only reacting reverse transcriptase ..
  22. ncbi Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways
    Abi G Aleyas
    Laboratory of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju, Republic of Korea
    J Immunol 183:2462-74. 2009
    ..However, few reports describing the interactions of DCs with Japanese encephalitis virus (JEV), which remains the most frequent cause of acute and epidemic viral encephalitis, are available...
  23. ncbi Detection of West Nile virus and Japanese encephalitis virus using real-time PCR with a probe common to both viruses
    Kazuya Shirato
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo, Hokkaido 060 0818, Japan
    J Virol Methods 126:119-25. 2005
    A diagnostic method to distinguish between West Nile virus (WNV) and Japanese encephalitis virus (JEV) based on fluorogenic real-time polymerase chain reaction (TaqMan) assays was developed...
  24. ncbi Chemokine profiling of Japanese encephalitis virus-infected mouse neuroblastoma cells by microarray and real-time RT-PCR: implication in neuropathogenesis
    Nimesh Gupta
    Division of Virology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Virus Res 147:107-12. 2010
    ..Pro- and anti-inflammatory agents targeted against chemokines such as CXCL10 may provide possible therapeutic modalities that can mitigate the morbidity associated with JEV infection of the CNS...
  25. ncbi Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis
    Ayan Ghoshal
    National Brain Research Centre, Manesar, Haryana, India
    Glia 55:483-96. 2007
    ..an experimental model of Japanese Encephalitis, to better understand the role played by microglia in Japanese Encephalitis Virus (JEV) infection...
  26. ncbi Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death
    Sulagna Das
    National Brain Research Centre, Manesar, Haryana, India
    J Neuroimmunol 195:60-72. 2008
    ..In vitro, these two cytokines differentially activate microglia and astrocyte, and also alter the by stander neuronal survival following treatment with these two cytokines...
  27. ncbi Japanese encephalitis in north Queensland, Australia, 1998
    J N Hanna
    Tropical Public Health Unit, Queensland Health, Cairns
    Med J Aust 170:533-6. 1999
    ..To describe the circumstances of two cases of Japanese encephalitis (JE) in north Queensland in 1998, including one acquired on the Australian mainland...
  28. pmc Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, No 160 Sec 3 Taichung Gang Road, Taichung 407, Taiwan
    J Virol 78:12107-19. 2004
    Infection with Japanese encephalitis virus (JEV) causes cerebral inflammation and stimulates inflammatory cytokine expression...
  29. ncbi Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus
    Gwong Jen J Chang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA
    Virology 306:170-80. 2003
    ..Eleven of twelve 2-day-old neonatal mice, derived from a pCB8D2-2J-2-9-1 immunized female mouse, survived intraperitoneal challenge of DEN-2 New Guinea C virus...
  30. ncbi Phylogenetic analysis of Japanese encephalitis virus: envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent
    P D Uchil
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore
    Am J Trop Med Hyg 65:242-51. 2001
    ..the complete nucleotide sequence for the Indian isolate (P20778; Genbank Accession number AF080251) of Japanese encephalitis virus (JEV)...
  31. pmc Development and evaluation of an enzyme-linked immunosorbent assay for quantifying antibodies to Japanese encephalitis virus nonstructural 1 protein to detect subclinical infections in vaccinated horses
    Eiji Konishi
    Department of Health Sciences, Kobe University School of Medicine, Suma ku, Kobe 654 0142, Japan
    J Clin Microbiol 42:5087-93. 2004
    Antibodies to Japanese encephalitis virus (JEV) nonstructural 1 (NS1) protein constitute a marker of natural JEV infection among populations vaccinated with inactivated JE vaccine...
  32. ncbi Does 1-octen-3-ol enhance trap collections of Japanese encephalitis virus mosquito vectors in northern Australia?
    Andrew E van den Hurk
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    J Am Mosq Control Assoc 22:15-21. 2006
    The responses of Japanese encephalitis virus (JEV) mosquito vectors to 1-octen-3-ol (octenol) and CO2 were evaluated using Centers for Disease Control (CDC) light traps at 3 sites in northern Australia...
  33. ncbi Immunogenicity of baculovirus expressed recombinant proteins of Japanese encephalitis virus in mice
    Dong Kun Yang
    National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry, Anyang, Korea
    J Vet Sci 6:125-33. 2005
    Genes encoding for the premembrane and envelope (prME), envelope (E) and nonstructural protein (NS1) of Japanese encephalitis virus (JEV) were cloned. Each protein was expressed in baculovirus expression system...
  34. ncbi Differential binding efficiency between the envelope protein of Japanese encephalitis virus variants and heparan sulfate on the cell surface
    Hsiuan Liu
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Med Virol 72:618-24. 2004
    ....
  35. ncbi Short report: a major genotype of Japanese encephalitis virus currently circulating in Japan
    Shao Ping Ma
    Division of Epidemiology, Department of Infectious Diseases, Oita Medical University, Oita, Japan
    Am J Trop Med Hyg 69:151-4. 2003
    A 240-nucleotide sequence of the capsid/premembrane gene region of 23 Japanese encephalitis virus (JEV) strains isolated in Tokyo and Oita, Japan was determined and phylogenetic analyses were performed...
  36. ncbi Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis
    F Guirakhoo
    OraVax, Inc, 38 Sidney Street, Cambridge, Massachusetts 02139, USA
    Virology 257:363-72. 1999
    ..All attenuating residues and the avirulent phenotype were preserved after 18 passages in cell cultures or 6 passages in mouse brains...
  37. ncbi Susceptibility of Culex sitiens to Japanese encephalitis virus in peninsular Malaysia
    I Vythilingam
    Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
    Trop Med Int Health 7:539-40. 2002
    ..Cx. sitiens became infected with JE virus on day 8 and subsequently it is able to transmit the virus when it takes a blood meal. Both parts of the experiment were carried out using artificial membrane feeding technique...
  38. ncbi Detection and stability of Japanese encephalitis virus RNA and virus viability in dead infected mosquitoes under different storage conditions
    Cheryl A Johansen
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, Queensland, Australia
    Am J Trop Med Hyg 67:656-61. 2002
    ..However, the semi-nested PCR was faster and more economical using larger pools. Results indicate that surveillance of JE virus in mosquitoes using the semi-nested PCR is an alternative to monitoring seroconversions in sentinel pigs...
  39. ncbi Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    Int J Antimicrob Agents 32:355-9. 2008
    ..The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in ..
  40. ncbi Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia
    Phan Thi Nga
    Department of Virology, National Institute of Hygiene and Epidemiology, 1 Yersin Street, Hanoi, Vietnam
    J Gen Virol 85:1625-31. 2004
    This study analyses the evolutionary relatedness of 16 Japanese encephalitis virus (JEV) isolates (nine from Vietnam and seven from Japan) to previously published JEV strains using E gene sequence data...
  41. ncbi Ecological studies of Japanese encephalitis virus in Hokkaido: interepidemic outbreaks of swine abortion and evidence for the virus to overwinter locally
    I Takashima
    Department of Veterinary Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Am J Trop Med Hyg 38:420-7. 1988
    Outbreaks of abortion and stillbirth caused by Japanese encephalitis virus were observed in swine populations in Hokkaido in 1984 and 1985...
  42. ncbi Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine
    Yaoming Li
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
    J Virol Methods 168:51-6. 2010
    Japanese encephalitis (JE) is caused by the Japanese encephalitis virus (JEV). It is a major public health problem in Asia...
  43. ncbi Experimental infections of pigs with Japanese encephalitis virus and closely related Australian flaviviruses
    D T Williams
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria
    Am J Trop Med Hyg 65:379-87. 2001
    ..Boosted levels of existing cross-neutralizing antibodies to JE virus suggested a role for this response in suppressing JE viremia...
  44. ncbi Diagnosis and genetic analysis of Japanese encephalitis virus infected in horses
    W C Lian
    Vaccine Center, Center for Disease Control, Taipei, Taiwan, Republic of China
    J Vet Med B Infect Dis Vet Public Health 49:361-5. 2002
    ..2-5.7% and at the amino acid level of 0-4.3% were conserved with other JE strains. The results demonstrated that the pathogens causing equine encephalitis were JE viruses. The strains were closely related to Taiwanese isolates...
  45. ncbi Genomic sequence of a Japanese encephalitis virus isolate from southern China
    Jiu Song Zhang
    Beijing Institute of Microbiology and Epidemiology, People s Republic of China
    Arch Virol 154:1177-80. 2009
    We determined the complete nucleotide sequence of a Japanese encephalitis virus (JEV) isolate (designated SH17M-2007) from a pool of Culex tritaeniorhynchus collected in southern China in 2007...
  46. ncbi Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells
    Tsuey Ching Yang
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
    Virus Res 143:77-85. 2009
    b>Japanese encephalitis virus (JEV) causes severe neurological diseases with a high fatality rate...
  47. ncbi Japanese encephalitis virus produces a CD4+ Th2 response and associated immunoprotection in an adoptive-transfer murine model
    S M Biswas
    National Institute of Virology, Pashan, Pune 411021, Maharashtra, India
    J Gen Virol 90:818-26. 2009
    Japanese encephalitis is an acute infection of the central nervous system caused by Japanese encephalitis virus (JEV)...
  48. pmc Genetic characterization of early isolates of Japanese encephalitis virus: genotype II has been circulating since at least 1951
    Amy J Schuh
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Gen Virol 91:95-102. 2010
    b>Japanese encephalitis virus (JEV) consists of five genotypes (GI-V)...
  49. ncbi Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner
    Chang Huei Tsao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan
    J Gen Virol 89:1930-41. 2008
    b>Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, replicates primarily at the endoplasmic reticulum and thereby triggers apoptosis of infected cells...
  50. ncbi Glial activation involvement in neuronal death by Japanese encephalitis virus infection
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung 407, Taiwan, ROC
    J Gen Virol 91:1028-37. 2010
    ..Although substantial activation of glia is observed in Japanese encephalitis virus (JEV)-induced Japanese encephalitis, the inflammatory responses and consequences of astrocytes and ..
  51. ncbi Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A
    Tetsuo Yamashita
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Virology 373:426-36. 2008
    The NS3 protein of Japanese encephalitis virus (JEV) is a large multifunctional protein possessing protease, helicase, and nucleoside 5'-triphosphatase (NTPase) activities, and plays important roles in the processing of a viral ..
  52. pmc Involvement of ceramide in the propagation of Japanese encephalitis virus
    Hideki Tani
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    J Virol 84:2798-807. 2010
    b>Japanese encephalitis virus (JEV) is a mosquito-borne RNA virus and one of the most important flaviviruses in the medical and veterinary fields...
  53. pmc Molecular basis for attenuation of neurovirulence of a yellow fever Virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE)
    J Arroyo
    OraVax, Inc, Cambridge, Massachusetts 02139, USA
    J Virol 75:934-42. 2001
    A yellow fever virus (YFV)/Japanese encephalitis virus (JEV) chimera in which the structural proteins prM and E of YFV 17D are replaced with those of the JEV SA14-14-2 vaccine strain is under evaluation as a candidate vaccine against ..
  54. ncbi Characterization of homologous defective interfering RNA during persistent infection of Vero cells with Japanese encephalitis virus
    Sung Wook Yoon
    Department of Biology and Research Institute of Basic Sciences, Kyung Hee University, Seoul 130 701, Korea
    Mol Cells 21:112-20. 2006
    ..Taken together, these ob-servations suggest that the generation of homologous DI RNA during successive JEV acute infections in Vero cells probably participates actively in persistent JEV infection...
  55. pmc Accumulation of a 3'-terminal genome fragment in Japanese encephalitis virus-infected mammalian and mosquito cells
    Kuo Chih Lin
    Department of Life Science, National Dong Hwa University, No 1 Section 2 University Road, Shoufeng, Hualien 97401, Taiwan, Republic of China
    J Virol 78:5133-8. 2004
    b>Japanese encephalitis virus (JEV) contains a single positive-strand RNA genome nearly 11 kb in length and is not formally thought to generate subgenomic RNA molecules during replication...
  56. ncbi Comparison of protective efficacies of plasmid DNAs encoding Japanese encephalitis virus proteins that induce neutralizing antibody or cytotoxic T lymphocytes in mice
    Eiji Konishi
    Department of Health Sciences, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    Vaccine 21:3675-83. 2003
    ....
  57. pmc Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction with 3' ends of Japanese encephalitis virus RNA and colocalization with the viral NS5 protein
    Shang Hua Yang
    Institute of Biotechnology and Department of Life Science, National Dong Hwa University, Taiwan, ROC
    J Biomed Sci 16:40. 2009
    Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of viral replication...
  58. ncbi Critical role of lipid rafts in virus entry and activation of phosphoinositide 3' kinase/Akt signaling during early stages of Japanese encephalitis virus infection in neural stem/progenitor cells
    Sulagna Das
    National Brain Research Centre, Manesar, Haryana, India
    J Neurochem 115:537-49. 2010
    b>Japanese encephalitis virus (JEV), the leading cause of acute encephalitis in South-East Asia is a neurotropic virus infecting various CNS cell types...
  59. ncbi Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein
    Chun Tang Chiou
    Graduate Institute of Life Sciences, National Defense Medical Center, 161 MinChuan E Rd Sec 6, Taipei 114, Taiwan
    J Gen Virol 84:2795-805. 2003
    Previously reported findings by our group showed that non-structural protein 3 (NS3) of Japanese encephalitis virus (JEV) was localized mainly in the JEV-induced convoluted membrane (CM), which has been proposed to originate from rough ..
  60. pmc Nuclear localization of Japanese encephalitis virus core protein enhances viral replication
    Yoshio Mori
    Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 79:3448-58. 2005
    b>Japanese encephalitis virus (JEV) core protein was detected in both the nucleoli and cytoplasm of mammalian and insect cell lines infected with JEV or transfected with the expression plasmid of the core protein...
  61. pmc A curious coincidence: mosquito biodiversity and the limits of the Japanese encephalitis virus in Australasia
    Stephane Hemmerter
    Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, New South Wales, Australia
    BMC Evol Biol 7:100. 2007
    ..major vector of endemic arboviruses in Australia and is also responsible for the establishment of the Japanese encephalitis virus (JEV) in southern Papua New Guinea (PNG) as well as its incursions into northern Australia...
  62. ncbi Multifront assault on antigen presentation by Japanese encephalitis virus subverts CD8+ T cell responses
    Abi G Aleyas
    College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju City 561 756, Republic of Korea
    J Immunol 185:1429-41. 2010
    b>Japanese encephalitis virus (JEV) is a frequent cause of acute and epidemic viral encephalitis...
  63. pmc The anamnestic neutralizing antibody response is critical for protection of mice from challenge following vaccination with a plasmid encoding the Japanese encephalitis virus premembrane and envelope genes
    E Konishi
    Department of Health Sciences, Kobe University School of Medicine, Kobe 654 0142, Japan
    J Virol 73:5527-34. 1999
    ..Taken together, these results indicate that neutralizing antibody produced following challenge provides the critical protective component in pcDNA3JEME-vaccinated mice...
  64. ncbi Protective efficacy of a plasmid DNA encoding Japanese encephalitis virus envelope protein fused to tissue plasminogen activator signal sequences: studies in a murine intracerebral virus challenge model
    Mundrigri S Ashok
    Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
    Vaccine 20:1563-70. 2002
    ..TPA) was fused to the full length (pCMVTE) or 398 amino terminal amino acids (pCMVTdeltaE) of Japanese encephalitis virus (JEV) envelope (E) protein...
  65. ncbi An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995
    J N Hanna
    Tropical Public Health Unit, Queensland Health, Cairns
    Med J Aust 165:256-60. 1996
    ..To determine the distribution of virus infection during an outbreak of Japanese encephalitis (JE) in the Torres Strait, and to describe the environmental factors facilitating the outbreak...
  66. ncbi ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells
    Nai Wan Hsiao
    Institute of Biotechnology, National Changhua University of Education, Changhua 500, Taiwan
    Antiviral Res 85:504-11. 2010
    ..b>Japanese encephalitis virus (JEV), a mosquito-borne neurotropic flavivirus, causes severe central nervous system diseases...
  67. ncbi Molecular epidemiological analysis of Japanese encephalitis virus in China
    Huan Yu Wang
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 YingXinJie, XuanWuQu, Beijing 100052, People s Republic of China
    J Gen Virol 88:885-94. 2007
    Sixty-two new Japanese encephalitis virus (JEV) isolates were obtained from mosquitoes, biting midges, human cerebrospinal fluid and human blood samples in China during 2002-2005...
  68. pmc Epitope-blocking enzyme-linked immunosorbent assay to differentiate west nile virus from Japanese encephalitis virus infections in equine sera
    Yoko Kitai
    Department of Health Sciences, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    Clin Vaccine Immunol 14:1024-31. 2007
    West Nile virus (WNV) is now widely distributed worldwide, except in most areas of Asia where Japanese encephalitis virus (JEV) is distributed...
  69. ncbi Emerging zoonotic encephalitis viruses: lessons from Southeast Asia and Oceania
    John S Mackenzie
    Australian Biosecurity CRC, Curtin University of Technology, Perth, Western Australia, Australia
    J Neurovirol 11:434-40. 2005
    ..Most of these viruses are zoonotic, either being arthropod-borne viruses or bat-borne viruses. Thus Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has spread through the Indonesian archipelago to Papua New Guinea (..
  70. ncbi Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Biotechnol Lett 30:205-14. 2008
    Immunogenicity and protective efficacy of recombinant Japanese encephalitis virus (JEV) NS1 proteins generated using DNA vaccines and recombinant viruses have been demonstrated to induce protection in mice against a challenge of JEV at a ..
  71. pmc Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus
    Eva Lee
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Virol 76:4901-11. 2002
    ..The in vivo mechanism for virulence attenuation of laboratory-derived variants of two flaviviruses in the Japanese encephalitis virus (JEV) serocomplex is described...
  72. ncbi Molecular characterization of an Indian isolate of Japanese encephalitis virus that shows an extended lag phase during growth
    S Vrati
    National Institute of Immunology, New Delhi, India
    J Gen Virol 80:1665-71. 1999
    The biological properties of an Indian isolate (GP78) of Japanese encephalitis virus (JEV) were characterized in tissue-cultured cells and mice and these were compared with the JaOArS982 strain from Japan...
  73. pmc Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6/36 mosquito cells?
    Junping Ren
    Department of Microbiology, Fourth Military Medical University, 17 Changle West Road, Xi an, 710032, People s Republic of China
    Virol J 4:83. 2007
    b>Japanese encephalitis virus (JEV) is a member of mosquito-borne Flaviviridae. To date, the mechanisms of the early events of JEV infection remain poorly understood, and the cellular receptors are unidentified...
  74. ncbi Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection
    Gajanan N Sapkal
    National Institute of Virology, Sus Road, Pashan, Pune, Maharashtra 411021 India
    Am J Trop Med Hyg 77:1139-45. 2007
    ..IgM capture ELISA showed recent Japanese encephalitis virus (JEV) infection...
  75. ncbi Japanese encephalitis virus infection decrease endogenous IL-10 production: correlation with microglial activation and neuronal death
    Vivek Swarup
    National Brain Research Centre, Manesar, Haryana, India
    Neurosci Lett 420:144-9. 2007
    ..The extent of progressive decrease in IL-10 level following viral infection is inversely proportional to the increase in the level of proinflammatory cytokines as well as negative consequences that follows viral infection...
  76. ncbi Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine
    Masaru Nawa
    Department of Microbiology, Saitama Medical School, 38 Moroyama, Saitama 350 0495, Japan
    J Gen Virol 84:1737-41. 2003
    Entry of Japanese encephalitis virus (JEV) into cells was analysed by using the vertebrate cell line Vero...
  77. pmc DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice
    Y L Lin
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Virol 72:191-200. 1998
    b>Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is a zoonotic pathogen that is prevalent in some Southeast Asian countries and causes acute encephalitis in humans...
  78. ncbi La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication
    Surender Vashist
    National Institute of Immunology, New Delhi 110067, India
    J Gen Virol 90:1343-52. 2009
    b>Japanese encephalitis virus (JEV) genome is a single-stranded, positive-sense RNA with non-coding regions (NCRs) of 95 and 585 bases at its 5' and 3' ends, respectively...
  79. ncbi Defective interfering RNAs of Japanese encephalitis virus found in mosquito cells and correlation with persistent infection
    Kuen Nan Tsai
    Institute of Biotechnology, Department of Life Science, National Dong Hwa University, Taiwan, ROC
    Virus Res 124:139-50. 2007
    ..In this study we have identified for the first time the generation of DI RNAs of Japanese encephalitis virus in C6/36 mosquito cells...
  80. pmc Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Virol 82:7009-21. 2008
    b>Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2...
  81. ncbi A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability
    Jian Jong Liang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 27:2746-54. 2009
    b>Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans...
  82. pmc Complement-dependent cytotoxicity assay for differentiating West Nile virus from Japanese encephalitis virus infections in horses
    Yoko Kitai
    Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan
    Clin Vaccine Immunol 17:875-8. 2010
    ..lysis of WNV NS1-expressing cells in a dose-dependent manner at higher percentages than sera from a Japanese encephalitis virus (JEV)-infected horse. The percentages of specific lysis for sera diluted 1:10 to 1:80 were <19...
  83. ncbi Evidence of frequent introductions of Japanese encephalitis virus from south-east Asia and continental east Asia to Japan
    Takeshi Nabeshima
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Sakamoto machi 1 12 4, Nagasaki City 852 8523, Japan
    J Gen Virol 90:827-32. 2009
    The Japanese encephalitis virus (JEV) circulating in Japan consists of viruses with multiple phylogenetic origins...
  84. ncbi Design and evaluation of a multi-epitope peptide against Japanese encephalitis virus infection in BALB/c mice
    Jian Chao Wei
    Key Laboratory of Animal Disease Diagnosis and Immunology, Ministry of Agriculture at Nanjing Agricultural University, Nanjing 210095, China
    Biochem Biophys Res Commun 396:787-92. 2010
    ..vaccination is a promising means to achieve protective immunity and to avoid immunopathology in Japanese encephalitis virus (JEV) infection...
  85. ncbi Japanese encephalitis virus infects neural progenitor cells and decreases their proliferation
    Sulagna Das
    National Brain Research Centre, Manesar, Haryana, India
    J Neurochem 106:1624-36. 2008
    b>Japanese encephalitis virus (JEV), a common cause of encephalitis in humans, especially in children, leads to substantial neuronal injury. The survivors of JEV infection have severe cognitive impairment, motor and behavioral disorders...
  86. ncbi Molecular characterization of the full-length genome of the Japanese encephalitis viral strain K87P39
    Sang Im Yun
    Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University, 48 Gaeshin dong, Heungduk Ku, Cheongju, South Korea
    Virus Res 96:129-40. 2003
    We have determined the complete nucleotide and deduced amino acid sequences of the Japanese encephalitis virus (JEV) strain K87P39, isolated from a pool of circulating Culex tritaeniorhynchus mosquitoes in Korea...
  87. ncbi Short report: genetic heterogeneity of Japanese encephalitis virus assessed via analysis of the full-length genome sequence of a Korean isolate
    J H Nam
    Department of Virology, Korea National Institute of Health, Seoul
    Am J Trop Med Hyg 65:388-92. 2001
    We determined the full-length genome sequence of Japanese encephalitis virus (JEV) K94P05 isolated in Korea...
  88. ncbi Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro
    L K Chen
    Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Virology 223:79-88. 1996
    Using gamma-ray irradiation, a pair of virulent (RP-9) and attenuated (RP-2ms) variants of Japanese encephalitis virus (JEV) were generated from a Taiwanese isolate, NT109...
  89. ncbi Natural infection with Japanese encephalitis virus among inhabitants of Japan: a nationwide survey of antibodies against nonstructural 1 protein
    Eiji Konishi
    Department of Health Sciences, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    Vaccine 24:3054-6. 2006
    ..Here, using a novel immunoassay, we obtained natural infection rates for 2001 of 0.2-3.4% in eight selected prefectures across Japan. Our results provide direct evidence of the risk of reemergence...
  90. ncbi Characterization of the E-138 (Glu/Lys) mutation in Japanese encephalitis virus by using a stable, full-length, infectious cDNA clone
    Zijiang Zhao
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu shi, Tokyo 183 8526, Japan
    J Gen Virol 86:2209-20. 2005
    A stable plasmid DNA, pMWJEAT, was constructed by using full-length Japanese encephalitis virus (JEV) cDNA isolated from the wild-type strain JEV AT31...
  91. ncbi [Molecular characterization of full-length genome of Japanese encephalitis virus isolated in Liaoning Province in 2008]
    Yu Xi Cao
    Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23:248-50. 2009
    To sequence and analyze the whole genome of Japanese encephalitis virus (JEV) isolated from mosquitoes in Liaoning province in 2008.
  92. ncbi Construction and application of chimeric virus-like particles of tick-borne encephalitis virus and mosquito-borne Japanese encephalitis virus
    Kentaro Yoshii
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Gen Virol 89:200-11. 2008
    ....
  93. ncbi Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus
    Yaoming Li
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China
    Vaccine 27:6004-10. 2009
    ..Design and development of safer and more efficacious vaccines against Japanese encephalitis virus (JEV) is a high-priority target in the world...
  94. pmc Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection
    Ren Jye Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Virol 78:9285-94. 2004
    ..In this study, we found that IFN-alpha had only some degree of antiviral activity against Japanese encephalitis virus (JEV) infection, in contrast to another flavivirus, dengue virus serotype 2, which was highly sensitive ..
  95. ncbi [Molecular characterization of full-length genome of Japanese encephalitis virus (SD08-10) newly isolated in Shandong province]
    Xiao Yan Gao
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23:242-4. 2009
    Sequence and analysis the complete nucleotide of the Japanese encephalitis virus (JEV) newly strain SD08-10, isolated in 2008 in Shandong, China in order to understand the characterization of the virus.
  96. ncbi Comparison of a dipstick enzyme-linked immunosorbent assay with commercial assays for detection of Japanese encephalitis virus-specific IgM antibodies
    A Shrivastva
    Division of Virology, Defense R and D Establishment, Jhansi Road, Gwalior, MP 474 002, India
    J Postgrad Med 54:181-5. 2008
    ..Japanese encephalitis (JE) is a major public health concern in Asia including India...
  97. ncbi Immunomodulatory cytokines determine the outcome of Japanese encephalitis virus infection in mice
    S M Biswas
    National Institute of Virology, Sus Road Campus, Pashan, Pune, Maharashtra, India
    J Med Virol 82:304-10. 2010
    b>Japanese encephalitis virus (JEV) induces an acute infection of the central nervous system, the pathogenic mechanism of which is not fully understood...
  98. ncbi [Molecular characterization of Japanese encephalitis virus isolated from Gansu province in 2008]
    Ming Hua Li
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23:251-3. 2009
    To sequence PrM and E gene of the Japanese encephalitis virus isolated from Gansu province in 2008 and analysis the genotype of new JEV isolates and the molecular characterization of E gene.
  99. ncbi Study of the effect of the midgut bacterial flora of Culex quinquefasciatus on the susceptibility of mosquitoes to Japanese encephalitis virus
    D T Mourya
    National Institute of Virology, 20 A, Dr Ambedkar Road, Pune, India
    Acta Virol 46:257-60. 2002
    ..and Aeromonas culicicola were used to study their effect on the susceptibility of mosquitoes to Japanese encephalitis virus (JEV)...
  100. ncbi Development of a simplified assay for the detection of neutralizing antibodies to Japanese encephalitis virus
    S H Ting
    Department of Microbiology, National University of Singapore, 5 Science Drive 2, Medical Faculty, 03-14, Singapore 117597, Singapore
    J Virol Methods 93:43-7. 2001
    b>Japanese encephalitis virus is a common cause of viral encephalitis in Asia with an estimated 45,000 cases annually. It causes significant morbidity and mortality...
  101. ncbi Phenotypic changes in the Japanese encephalitis virus after one passage in Neuro-2a cells: generation of attenuated strains of the virus
    Shyan Song Chiou
    Graduate Institute of Veterinary Public Health, National Chung Hsing University, Taichung 40227, Taiwan
    Vaccine 26:15-23. 2007
    ..As a result, most, if not all, low-virulent variants were generated in a relatively short time, all which have the potential to be live-attenuated vaccine candidates of the JE virus...

Research Grants45

  1. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ..Gliosis has been demonstrated in vitro and in vivo following infection with Japanese encephalitis virus (JEV) and inflammatory mediators associated with gliosis have been detected in the brain during viral ..
  2. Cellular Components Involved in Japanese Encephalitis Virus Entry
    Young Min Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this laboratory is to understand how Japanese encephalitis virus (JEV) gains access to the interior of human cells, the first step in an infection process that involves a ..
  3. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human immunodeficiency virus (HIV)...
  4. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many flaviviruses, including West Nile virus (WNV), Japanese encephalitis virus, tick- borne encephalitis virus and dengue virus, are significant human pathogens...
  5. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
    ..West Nile virus, (WNV) the most common cause of epidemic encephalitis in the United States and Japanese encephalitis virus (JEV), the most common cause of viral encephalitis worldwide...
  6. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..candidate vaccines to influenza (currently in clinical trial) and flaviviruses such as West Nile virus, Japanese encephalitis virus, and Dengue virus by VaxInnate...
  7. Targeting induction of calcium buffer proteins for treatment of viral encephaliti
    John D Morrey; Fiscal Year: 2013
    ..establish activity of the lead compound in rodents, and to investigate this therapeutic approach with Japanese encephalitis virus (JEV)...
  8. Multimodal imaging of antibody-mediated therapy during acute viral encephalitides
    William Paul Duprex; Fiscal Year: 2013
    ..disease progression for two highly neuropathogenic biodefense-relevant agents, Nipah virus (NiV) and Japanese encephalitis virus (JEV);and (ii) to assess the CNS biodistribution and efficacy of highly neutralizing recombinant human ..
  9. Identification and evaluation of novel therapeutic targets for virus-induced neur
    Kenneth L Tyler; Fiscal Year: 2013
    ..Viral encephalitis, including encephalitis induced by the arboviruses West Nile virus (WNV) and Japanese encephalitis virus (JEV), is a major source of morbidity and mortality both in the U.S. and throughout the world...
  10. ISG CONTROL OF FLAVIVIRUS INFECTION
    Michael S Diamond; Fiscal Year: 2013
    ..This genus includes viruses (West Nile virus (WNV), Japanese encephalitis virus (JEV) and Dengue virus (DENV)) that are re-emerging and becoming endemic in new areas of the world...
  11. Evaluation of Host miRNAs as Therapeutics against Encephalitogenic Flaviviruses
    Alec Hirsch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The neurotropic flaviviruses, including West Nile virus (WNV) and Japanese Encephalitis virus (JEV) are mosquito borne viruses that cause significant morbidity and mortality worldwide...
  12. Persistence of West Nile virus in California
    William K Reisen; Fiscal Year: 2012
    ..Louis encephalitis virus (SLEV), a previously endemic and closely related virus within the Japanese encephalitis virus (JEV) serocomplex...
  13. Development of Novel Small Molecule Flavivirus Inhibitors
    ERIC W BARKLIS; Fiscal Year: 2010
    ..in infected cells, and that TYT-1 analogues inhibit replication of related flaviviruses such as the Japanese encephalitis virus (JEV) and the category A biodefense pathogen Dengue virus (DENV)...
  14. YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINES
    William Wold; Fiscal Year: 2002
    ..an engineered chimeric virus can provide protective immunity against challenge with neuropathogenic Japanese encephalitis virus in adult mice, and to compare relative immunogenicity and protection with available Japanese ..
  15. Molecular Evolution of flavivirus-resistance in mice
    Stephane Boissinot; Fiscal Year: 2005
    ..symptoms and long term effects similar to those observed in humans infected by the West Nile virus and Japanese encephalitis virus. The viral infection and propagation will be examined at the individual level and at the tissue and ..
  16. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2009
    ..will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and Norwalk Virus...
  17. 'Fat' Nucleosides and Nucleotides
    RAMACHANDRA HOSMANE; Fiscal Year: 2005
    ..C virus (HBV and HCV), West Nile virus (WNV), Epstein-Barr virus (EBV), Vericella Zoster virus (VZV), Japanese Encephalitis virus (JEV), Rhino virus (RV), Herpes Simplex (HSV-1 and HSV-2) viruses, and Measles virus (MV)...
  18. Regulation of Antigen Presentation by APLP-2
    Joyce Solheim; Fiscal Year: 2005
    ..biodefense priority pathogens (Hantaan virus, Mycobacterium tuberculosis, influenza A, dengue virus, Japanese encephalitis virus, and Listeria monocytogenes)...
  19. Regulation of Antigen Presentation by APLP-2
    CHANTEY MORRIS; Fiscal Year: 2004
    ..NIAID priority pathogens (Hantaan virus, Mycobacterium tuberculosis, influenza A virus, dengue virus, Japanese encephalitis virus, and Listeria monocytogenes)...
  20. A single-dose prophylactic Japanese Encephalitis vaccine
    Eszter Nagy; Fiscal Year: 2007
    ..the company can employ under this grant application to develop a single dose, prophylactic vaccine for Japanese encephalitis virus (JEV). JEV has been classified as a "Category B Priority Pathogen for Biodefense...
  21. ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDS
    William Reisen; Fiscal Year: 2002
    ..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..
  22. HOST COMPETENCE FACTORS AFFECT ARBOVIRUS TRANSMISSION
    William Reisen; Fiscal Year: 2003
    ..Studies will assess how alternating sequential infections between vertebrate and vector species that are part of the natural transmission cycle may alter virus genetics and fitness. ..
  23. LIVE, ATTENUATED, RECOMBINANT VACCINE - WEST NILE VIRUS
    Thomas Monath; Fiscal Year: 2002
    ..abstract_text> ..
  24. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  25. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 2001
    ....
  26. Epidemiology of Yellow Fever in the Americas
    Robert Tesh; Fiscal Year: 2005
    ..Most of the work will be done in laboratories at the University of Texas Medical Branch, Center for Tropical Diseases; but a small portion will be done at the Evandro Chagas Institute in Belem, Brazil. ..
  27. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  28. Enzymatic Differences Among Hepatitis C Virus Genotypes
    David Frick; Fiscal Year: 2007
    ..abstract_text> ..
  29. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  30. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  31. Hepatitis C VIrus NS3 Helicase Inhibitor Discovery
    David Frick; Fiscal Year: 2008
    ..The goal here is to find chemicals that prevent the virus from replicating in human cells. [unreadable] [unreadable] [unreadable]..
  32. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  33. Attenuated West Nile virus envelope protein mutants
    David Beasley; Fiscal Year: 2006
    ..These studies will identify E protein residues that can impart an attenuated phenotype and these will be exploited for WNV vaccine development in a subsequent R01 grant application. ..
  34. Optimization of a Multivalent Tuberculosis Vaccine
    Anne De Groot; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Development of De-immunized Botulinum Neurotoxin Type A for Dystonia
    Anne De Groot; Fiscal Year: 2008
    ..Public Health Relatedness: Knowledge of the elements of botulinum neurotoxin type A that give rise to its immunogenicity will contribute to the development of improved dystonia therapy. [unreadable] [unreadable] [unreadable]..
  36. Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact
    Diane Griffin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. Novel Smallpox Vaccine Derived from VV/VAR Immunome
    Anne De Groot; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  38. A Genome-Derived, Epitope-Driven H. Pylori Vaccine
    Anne De Groot; Fiscal Year: 2006
    ..pylori disease as our correlate of efficacy. ..
  39. A GENOME-DERIVED, EPITOPE-DRIVEN TULAREMIA VACCINE
    Anne De Groot; Fiscal Year: 2005
    ..abstract_text> ..
  40. Epitope Driven HIV Vaccine Development
    Anne De Groot; Fiscal Year: 2005
    ..The final product of this joint effort will be a set of plasmids to be combined in an epitope-driven, oligonucleotide-based DNA cocktail vaccine for HIV. ..
  41. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  42. 2nd Annual Vaccine Renaissance Conference, RI
    Anne De Groot; Fiscal Year: 2006
    ..More than 80 participants attended that 1st conference from the[unreadable] New England region and beyond. ..
  43. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2002
    ..abstract_text> ..