lymphocytic choriomeningitis virus

Summary

Summary: The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.

Top Publications

  1. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
  2. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
  3. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
  4. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
  5. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  6. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
  7. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
  8. pmc Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
    Surojit Sarkar
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:625-40. 2008
  9. ncbi Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
    W Cao
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 282:2079-81. 1998
  10. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009

Detail Information

Publications327 found, 100 shown here

  1. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  2. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  3. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  4. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
    ..These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation...
  5. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), and compared these with the gene profile of functional memory CD8 T cells...
  6. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..the molecular signature of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic choriomeningitis virus (LCMV)-specific CD8(+) T cells from chronic infection to functional LCMV-specific effector and ..
  7. pmc IL-21 is required to control chronic viral infection
    Heidi Elsaesser
    Department of Microbiology, Immunology, and Molecular Genetics and University of California, Los Angeles UCLA AIDS Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Science 324:1569-72. 2009
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  8. pmc Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
    Surojit Sarkar
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:625-40. 2008
    ..These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation...
  9. ncbi Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
    W Cao
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 282:2079-81. 1998
    A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to be alpha-dystroglycan (alpha-DG)...
  10. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
    ..IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection...
  11. ncbi IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Cell 144:601-13. 2011
    ..The IL-7-mediated effects were dependent on endogenous IL-6. These attributes of IL-7 have profound implications for its use as a therapeutic in the treatment of chronic viral diseases...
  12. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  13. pmc Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    James A Harker
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Science 334:825-9. 2011
    ..This resulted in escalation of germinal center reactions and improved antibody responses. Our results uncover an antiviral strategy that helps to safely resolve a persistent infection in vivo...
  14. pmc Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus
    Luis Martinez-Sobrido
    Molecular Integrative Neuroscience Department MIND, The Scripps Research Institute, IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 80:9192-9. 2006
    The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a formidable battle horse for the study of viral immunology, as well as viral persistence and associated diseases...
  15. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
    ..In the present study, we have characterized the NP-Z interaction for the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)...
  16. pmc Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus
    Luis Martinez-Sobrido
    Department of Immunology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 83:11330-40. 2009
    b>Lymphocytic choriomeningitis virus (LCVM) nucleoprotein (NP) counteracts the host type I interferon (IFN) response by inhibiting activation of the IFN regulatory factor 3 (IRF3)...
  17. pmc Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P
    Winfried R Beyer
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
    J Virol 77:2866-72. 2003
    The envelope glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) is posttranslationally cleaved into two subunits...
  18. pmc Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection
    Jeffrey C Nolz
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Immunity 34:781-93. 2011
    ..Thus, repeated antigen stimulation shapes memory CD8+ T cell populations to either enhance or decrease per cell protective immunity in a pathogen-specific manner, a concept of importance in vaccine design against specific diseases...
  19. pmc Plasmacytoid dendritic cells control T-cell response to chronic viral infection
    Luisa Cervantes-Barragan
    Institute of Immunobiology, Kantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland
    Proc Natl Acad Sci U S A 109:3012-7. 2012
    ..Furthermore, pDC-deficient animals failed to clear lymphocytic choriomeningitis virus (LCMV) from hematopoietic organs during persistent LCMV infection...
  20. pmc Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
    Laura M Fahey
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 208:987-99. 2011
    ..Importantly, this sustained CD4 T cell functionality is critical to maintain immunity and ultimately aid in the control of persistent viral infection...
  21. pmc The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies
    Mar Perez
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:12978-83. 2003
    By using a reverse genetics system that is based on the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), we have identified the arenavirus small RING finger Z protein as the main driving force of virus budding...
  22. pmc Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..By examining the response to infection with lymphocytic choriomeningitis virus using IFN-I receptor-deficient (IFN-IR(0)) and -sufficient CD8 T cells adoptively transferred into ..
  23. pmc Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties
    Rachel L Rutishauser
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 31:296-308. 2009
    ..repressor Blimp-1 enhanced the formation of terminally differentiated CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection, and Blimp-1 deficiency promoted the acquisition of memory cell properties by ..
  24. pmc Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens
    George A Punkosdy
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:3677-82. 2011
    ..Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3(+) Treg that is dependent on retroviral superantigen (sag) ..
  25. pmc Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner
    Daniel L Popkin
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 9:212-22. 2011
    The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV...
  26. pmc Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence
    Brian M Sullivan
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2969-74. 2011
    ..The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is widely used as a model system for studying persistent and acute infections, as well as for ..
  27. pmc Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 84:9452-62. 2010
    Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic choriomeningitis virus (LCMV) infection induces robust type I IFN production in its natural host, the mouse...
  28. ncbi Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections
    Fei Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:5936-40. 2005
    ..This technique will be useful when evaluating in vivo immune cell activity in many situations, including a variety of noninfectious (e.g., autoimmune) diseases...
  29. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific CD8+ T cells lacking both T-bet and Eomes differentiate into an interleukin-..
  30. pmc Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1
    Anju Singh
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Cell Biol 30:5145-59. 2010
    ..These findings provide critical insights into the cell cycle regulation of CD8 T-cell homeostasis and suggest that modulation of p27(Kip1) could bolster vaccine-induced T-cell memory and protective immunity...
  31. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
    ..Here we document self-association (homotypic interaction) of the NP of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), as well as those of the hemorrhagic fever (HF) arenaviruses Lassa virus (LASV) and Machupo ..
  32. pmc Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    Roberto Tinoco
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0322, USA
    Immunity 31:145-57. 2009
    ..Our findings reveal persisting TGF-beta-Smad signaling as a hallmark and key regulator of CD8(+) T cell responses during chronic viral infections in vivo...
  33. ncbi Memory CD8 T-cell compartment grows in size with immunological experience
    Vaiva Vezys
    Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 457:196-9. 2009
    ..Developing vaccines that abundantly introduce new memory CD8 T cells should not necessarily ablate pre-existing immunity to other infections...
  34. pmc Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
    Lukas Flatz
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Nat Med 16:339-45. 2010
    b>Lymphocytic choriomeningitis virus (LCMV) exhibits natural tropism for dendritic cells and represents the prototypic infection that elicits protective CD8(+) T cell (cytotoxic T lymphocyte (CTL)) immunity...
  35. pmc Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought
    David Masopust
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 81:2002-11. 2007
    ..a more complete accounting of the CD8 T-cell response generated upon infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV)...
  36. pmc Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    J Neuroimmunol 194:70-82. 2008
    ..In the present study, we demonstrated that central nervous system (CNS) glial cells are activated by Lymphocytic Choriomeningitis Virus (LCMV) in a TLR2-MyD88/Mal-dependent manner...
  37. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
    ..Using different strains of lymphocytic choriomeningitis virus (LCMV), we compared responses to the same CD8 T-cell epitopes during acute or chronic infection...
  38. ncbi Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    Michael J Fuller
    Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 172:4204-14. 2004
    ..In this study, we have used the well-defined system of lymphocytic choriomeningitis virus (LCMV) infection of mice to determine quantitative and qualitative changes in virus-specific CD8 T ..
  39. pmc Hemorrhagic fever occurs after intravenous, but not after intragastric, inoculation of rhesus macaques with lymphocytic choriomeningitis virus
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland, Biotech Center, Baltimore, Maryland 21201, USA
    J Med Virol 67:171-86. 2002
    ..We describe infection of rhesus macaques with the prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), using the WE strain that has been known to cause both encephalopathy and multifocal ..
  40. pmc RING finger Z protein of lymphocytic choriomeningitis virus (LCMV) inhibits transcription and RNA replication of an LCMV S-segment minigenome
    T I Cornu
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:9415-26. 2001
    ..The role of Z during the Lymphocytic choriomeningitis virus (LCMV) life cycle is poorly understood...
  41. ncbi Lymphocytic choriomeningitis virus uses a novel endocytic pathway for infectious entry via late endosomes
    Katharina Quirin
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Virology 378:21-33. 2008
    The endocytic entry of lymphocytic choriomeningitis virus (LCMV) into host cells was compared to the entry of viruses known to exploit clathrin or caveolae/raft-dependent pathways...
  42. ncbi Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions
    Stefan Kunz
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 314:168-78. 2003
    The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) serves as virus attachment protein to its receptor on host cells and is a key determinant for cell tropism, pathogenesis, and epidemiology of the virus...
  43. ncbi Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 317:670-4. 2007
    ..We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues...
  44. pmc Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
    L P Cousens
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Exp Med 189:1315-28. 1999
    ..T cell IFN-gamma production were defined in studies evaluating CD8 T cell responses during lymphocytic choriomeningitis virus infections of mice. Two divergent supporting pathways were characterized...
  45. pmc Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    A Gallimore
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 187:1647-57. 1998
    Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I-restricted cytotoxic T cells (CTLs), which normally resolve the infection...
  46. pmc Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection
    Monica Macal
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Cell Host Microbe 11:617-30. 2012
    ..We find that the Old World arenaviruses lymphocytic choriomeningitis virus clone 13 (LCMV Cl13) and Lassa virus bind pDCs to a greater extent than cDCs...
  47. pmc A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002098. 2011
    ..Our results demonstrate an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection...
  48. pmc Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation
    Joyce K Hu
    Division of Rheumatology, Department of Medicine, and Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:E118-27. 2011
    ..We found that in mice infected with lymphocytic choriomeningitis virus, colocalization of virus-specific CD8 T cells with antigen in spleen is dependent on expression of ..
  49. pmc Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15430-5. 2007
    ..The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistent lymphocytic choriomeningitis virus (LCMV) infection, we demonstrate viral targeting of fibroblastic reticular cells (FRC) in the ..
  50. ncbi An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis
    Veronica Martin
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, C Nicolás Cabrera, 1, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Gen Virol 91:990-1003. 2010
    ..studies have documented that, in the presence of the mutagenic base analogue 5-fluorouracil (FU), lymphocytic choriomeningitis virus (LCMV) that persisted in BHK-21 cells decreased its infectivity to a larger extent than ..
  51. pmc Glycosylation modulates arenavirus glycoprotein expression and function
    Cyrille J Bonhomme
    University of California, Irvine, Department of Molecular Biology and Biochemistry and Division of Infectious Disease, 3205 McGaugh Hall, Irvine, CA 92697 3900, USA
    Virology 409:223-33. 2011
    The glycoprotein of lymphocytic choriomeningitis virus (LCMV) contains nine potential N-linked glycosylation sites. We investigated the function of these N-glycosylations by using alanine-scanning mutagenesis...
  52. pmc Development of a new hydrogen peroxide–based vaccine platform
    Ian J Amanna
    Najít Technologies, Beaverton, Oregon, USA
    Nat Med 18:974-9. 2012
    ..Mice immunized with H(2)O(2)-inactivated lymphocytic choriomeningitis virus (LCMV) generated cytolytic, multifunctional virus-specific CD8(+) T cells that conferred protection ..
  53. ncbi Type I IFN substitutes for T cell help during viral infections
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 186:754-63. 2011
    ..In this study, we compared CD8(+) T cell responses elicited by lymphocytic choriomeningitis virus infection, as prototype of a T cell help independent infection, with T cell help dependent CD8(+) T ..
  54. ncbi Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
    L K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 11:733-42. 1999
    ..These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime...
  55. pmc Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S Euclid, St Louis, MO 63110, USA
    Cell Host Microbe 11:631-42. 2012
    ..Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts ..
  56. ncbi Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 185:2182-90. 2010
    ..and functional qualities of these cells with memory T cells generated after systemic infection with lymphocytic choriomeningitis virus (LCMV)...
  57. ncbi The primary structure of the lymphocytic choriomeningitis virus L gene encodes a putative RNA polymerase
    M Salvato
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Virology 169:377-84. 1989
    The complete RNA sequence of the L protein gene of lymphocytic choriomeningitis virus (LCMV) is presented...
  58. pmc Dual role of the lymphocytic choriomeningitis virus intergenic region in transcription termination and virus propagation
    Daniel D Pinschewer
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:4519-26. 2005
    Each genome segment of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), encodes two genes in ambisense orientation, separated by an intergenic region (IGR)...
  59. ncbi Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
    Marc Pellegrini
    The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
    Nat Med 15:528-36. 2009
    ..The ability of adjuvant IL-7 to antagonize inhibitory networks at the cellular and molecular level has major implications for immunotherapy in the treatment of tumors...
  60. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  61. pmc Intravital imaging of CTLs killing islet cells in diabetic mice
    Ken Coppieters
    Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    J Clin Invest 122:119-31. 2012
    ..Collectively, these data portray the kinetics of CTL homing to and between antigenic target sites as a stochastic process at the sub-organ level and argue against a dominant influence of chemotactic gradients...
  62. ncbi CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 16:403-15. 2002
    ..Furthermore, protection of prediabetic recipients was autoantigen specific and did not result in generalized immunosuppression. The origin, function, and therapeutic potential of these bitypic NK/DC regulatory cells is discussed...
  63. pmc Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Antiviral Res 92:125-38. 2011
    Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human ..
  64. ncbi Lymphocytic choriomeningitis infection of the central nervous system
    Silvia S Kang
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 13:4529-43. 2008
    ..b>Lymphocytic choriomeningitis virus (LCMV) is a powerful model system to explore these potential outcomes of CNS infection due to the ..
  65. ncbi Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection
    Colin Havenar-Daughton
    Department of Immunology and Washington National Primate Center, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA
    J Immunol 176:3315-9. 2006
    ..In response to lymphocytic choriomeningitis virus immunization, WT CD4 T cells expanded approximately 100-fold, whereas IFN-IR(0) CD4 T cells expanded ..
  66. pmc Revisiting estimates of CTL killing rates in vivo
    Andrew Yates
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e1301. 2007
    ..We reanalyse data previously used to estimate killing rates of CTL specific for two epitopes of lymphocytic choriomeningitis virus (LCMV) in mice and show that, contrary to previous estimates the "killing rate" of effector CTL is ..
  67. pmc Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
    V C Asensio
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:7832-40. 1997
    ..The pattern of chemokine gene expression in LCM may profoundly influence the characteristic phenotype and response of leukocytes in the brain and contribute to the immunopathogenesis of this fatal CNS infection...
  68. pmc Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity
    A Grande-Pérez
    Molecular Medicine and Gene Therapy Unit, Department of Medicine, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 99:12938-43. 2002
    ..Here we report that lymphocytic choriomeningitis virus, the prototype arenavirus, is extremely susceptible to extinction mutagenesis by the base analog 5-..
  69. pmc Two RING finger proteins, the oncoprotein PML and the arenavirus Z protein, colocalize with the nuclear fraction of the ribosomal P proteins
    K L Borden
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Virol 72:3819-26. 1998
    ..leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to PML and can relocate the nuclear bodies...
  70. pmc Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan
    S Kunz
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Cell Biol 155:301-10. 2001
    alpha-Dystroglycan (DG) has been identified as the cellular receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa fever virus (LFV)...
  71. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
    ..In C57BL/6 mice, the acute cytotoxic T cell response against lymphocytic choriomeningitis virus is directed against immunodominant epitopes derived from the glycoprotein (gp33-41) and the ..
  72. pmc Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:918-25. 2002
    ..In addition, we have established an in vivo approach for assessing the intricacies of antigen-specific T cell activation, migration, engagement, memory and other defining elements of adaptive immunity...
  73. pmc Characterization of the genomic promoter of the prototypic arenavirus lymphocytic choriomeningitis virus
    Mar Perez
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:1184-94. 2003
    The genome of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense, single-strand RNA segments designated L and S. Arenavirus genomes exhibit high sequence conservation at their 3' ends...
  74. ncbi Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development
    Antje Rhode
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3516-24. 2005
    ..RIP-CXCL10 mice crossed to RIP-nucleoprotein (NP) mice expressing the NP of the lymphocytic choriomeningitis virus in the beta cells had massively accelerated type 1 diabetes after lymphocytic choriomeningitis virus ..
  75. pmc A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection
    Haina Shin
    Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA 19104, USA
    Immunity 31:309-20. 2009
    ..Thus, we identify Blimp-1 as a transcriptional regulator of CD8(+) T cell exhaustion during chronic viral infection and propose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhaustion...
  76. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin beta3...
  77. pmc Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence
    Ana Grande-Pérez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    J Virol 79:10451-9. 2005
    ..Here we show that 5-fluorouracil (FU)-induced mutagenesis of the arenavirus lymphocytic choriomeningitis virus (LCMV) resulted in preextinction populations whose consensus genomic nucleotide sequence remained ..
  78. pmc Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    Jiyun V Kim
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 457:191-5. 2009
    b>Lymphocytic choriomeningitis virus infection of the mouse central nervous system (CNS) elicits fatal immunopathology through blood-brain barrier breakdown and convulsive seizures...
  79. pmc Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Virol 77:1727-37. 2003
    b>Lymphocytic choriomeningitis virus (LCMV) and Lassa virus can cause hemorrhagic fever and liver disease in primates...
  80. pmc Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo
    Megan M McCausland
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol Methods 147:167-76. 2008
    ..We have developed a QPCR assay to accurately quantify lymphocytic choriomeningitis virus (LCMV) in infected mice. We first validated this assay using plasmid DNA and LCMV viral stocks...
  81. ncbi CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion
    Peter Aichele
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 176:4525-9. 2006
    ..T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR...
  82. pmc A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding
    Althea A Capul
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, IMM 6, La Jolla, CA 92037, USA
    Virology 382:107-14. 2008
    ..In addition, compelling evidence indicates that the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance...
  83. pmc LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regeneration
    I S Lukashevich
    Biotechnology Center, Institute of Human Virology, University of Maryland, Baltimore, Maryland 21201, USA
    Arch Virol 149:2319-36. 2004
    ..Previously we demonstrated that LCMV-ARM infection protected rhesus macaques challenged with LCMV-WE. Here we have shown that the protected animals have no signs of hepatitis and hepatocyte proliferation...
  84. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...
  85. pmc Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance
    Maya F Kotturi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:2124-33. 2008
    The primary CD8(+) T cell response of C57BL/6J mice against the 28 known epitopes of lymphocytic choriomeningitis virus (LCMV) is associated with a clear immunodominance hierarchy whose mechanism has yet to be defined...
  86. ncbi Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination
    Alexander K Nussbaum
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 175:1153-60. 2005
    ..In this study we investigated the CD8(+) T cell responses to lymphocytic choriomeningitis virus infection and DNA immunization in wild-type mice and in mice lacking the immunoproteasome subunits ..
  87. pmc Antiviral CD4+ memory T cells are IL-15 dependent
    Jared F Purton
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 204:951-61. 2007
    ..Therefore, under normal physiological conditions, homeostasis of CD8(+) and CD4(+) memory cells is quite similar and involves IL-15 and IL-7...
  88. ncbi Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
    Maria P Rodriguez-Carreno
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 335:87-98. 2005
    ..can induce CD8(+) T cell responses in mice and can protect against challenge with two arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV)...
  89. ncbi Arenavirus diversity and evolution: quasispecies in vivo
    N Sevilla
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain
    Curr Top Microbiol Immunol 299:315-35. 2006
    ..The significant variation in biological properties observed among lymphocytic choriomeningitis virus (LCMV) strains, the prototypic arenavirus, indicates to what extent a quasis-pecies dynamics may ..
  90. pmc Genetic and biochemical evidence for an oligomeric structure of the functional L polymerase of the prototypic arenavirus lymphocytic choriomeningitis virus
    Ana B Sanchez
    Department of Neuropharmacology IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 79:7262-8. 2005
    ..these conserved residues in the polymerase activity of the L protein of the prototypic arenavirus, lymphocytic choriomeningitis virus (LCMV), in vivo using a minigenome rescue assay...
  91. pmc RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virus
    Ana B Sanchez
    Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 79:11071-81. 2005
    ..Moreover, the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is an important model for the study of viral persistence and associated diseases, as well as ..
  92. ncbi Vaccination against lymphocytic choriomeningitis virus infection in MHC class II-deficient mice
    Peter Johannes Holst
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen DK 2200, Denmark
    J Immunol 186:3997-4007. 2011
    ..response could be elicited in MHC class II-deficient mice by vaccination with adenovirus encoding lymphocytic choriomeningitis virus (LCMV) glycoprotein tethered to MHC class II-associated invariant chain...
  93. ncbi Post-translational modification of {alpha}-dystroglycan is not critical for lymphocytic choriomeningitis virus receptor function in vivo
    Mauro Imperiali
    Institute for Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Gen Virol 89:2713-22. 2008
    ..alpha-DG) is a ubiquitously expressed molecule that has been identified as a cellular receptor for lymphocytic choriomeningitis virus (LCMV) and other arenaviruses...
  94. ncbi Lymphocytic choriomeningitis virus--an old enemy up to new tricks
    C J Peters
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, USA
    N Engl J Med 354:2208-11. 2006
  95. ncbi CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Edith M Janssen
    Division of Cellular Immunology and Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 421:852-6. 2003
    ..Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen...
  96. ncbi CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system
    Jeanette Erbo Christensen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    J Immunol 176:4235-43. 2006
    ..This was done through analysis of CXCL10-deficient mice infected intracerebrally with lymphocytic choriomeningitis virus, which in normal immunocompetent mice induces a fatal CD8(+) T cell-mediated meningoencephalitis...
  97. pmc High diversity and ancient common ancestry of lymphocytic choriomeningitis virus
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1093-100. 2010
    b>Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae...
  98. ncbi Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection
    P Seiler
    Department of Pathology, University Hospital Zurich, Switzerland
    Eur J Immunol 27:2626-33. 1997
    ..MZM- and MM-depleted mice were not able to control an infection with lymphocytic choriomeningitis virus (LCMV)...
  99. ncbi Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:291-9. 1999
    ..compared with in vivo generated effector and memory T cells expressing the same TCR specific for lymphocytic choriomeningitis virus. Upon restimulation in vitro, the same minimal concentrations of the full agonist peptide p33 and ..
  100. pmc Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels
    Kathryn J Mackerness
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:3643-51. 2010
    ..We show that virus-specific CD8 T cells clearly respond during the early stages of chronic lymphocytic choriomeningitis virus infection, and that this early T cell response is more pronounced than that initially observed in ..
  101. pmc Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection
    Frederik Graw
    Institute of Integrative Biology, ETH Zurich, Universitatstrasse 16, 8092 Zurich, Switzerland
    Proc Biol Sci 278:3395-402. 2011
    ..the killing efficacy of CD8(+) T-cell responses in mice acutely and persistently infected with the lymphocytic choriomeningitis virus, using an in vivo CTL killing assay...

Research Grants62

  1. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..I recently reported that in vivo infection of mice with Lymphocytic choriomeningitis virus (LCMV) differentially modulates subsequent TLR challenges inhibiting TLR3, TLR7 and TLR9 responses ..
  2. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Using infectious agents such as lymphocytic choriomeningitis virus and Listeria monocytogenes to infect mice we will probe the contribution of CD4+ T cells during the ..
  3. Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1
    Marulasiddappa Suresh; Fiscal Year: 2012
    ..Our studies using the mouse model of lymphocytic choriomeningitis virus (LCMV) have shown that genetic deficiency of cyclin dependent kinase inhibitor p27Kip1 not only ..
  4. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2012
    ..Omann's syndrome;and mouse models of three infectious diseases: schistosomiasis, malaria, and lymphocytic choriomeningitis virus (LCMV) infection...
  5. MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENS
    Ellen A Robey; Fiscal Year: 2010
    ..mutant mice/cells to several NIAID priority pathogens (Toxoplasma gondii, Influenza, Vaccinia, Lymphocytic Choriomeningitis virus) and other pathogens (Murine &Human cytomegalovirus, Murine herpes virus 68, Moloney Murine ..
  6. Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
    Elina I Zuniga; Fiscal Year: 2012
    ..We have therefore chosen to use chronic lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse, as a model system...
  7. Single-cycle Infectious Candid#1 to Study Hemorrhagic Fever New World Arenavirus
    Luis Martinez-Sobrido; Fiscal Year: 2013
    ..for the first time, the generation of a single-cycle infectious, reporter-expressing, Old World Lymphocytic Choriomeningitis Virus (LCMV) where we replaced the viral glycoprotein (GP) with a reporter green fluorescent protein (GFP),..
  8. Evaluation of LASV Protective Immunity in Mice Using Reassortant Virus ML29
    MARCO AURELIO GOICOCHEA; Fiscal Year: 2010
    ..p.) immunization, similar to the closely related prototype arenavirus lymphocytic choriomeningitis virus (LCMV)...
  9. Host Genetic Factors to Combat Lassa Hemorrhagic Fever
    Michael B Oldstone; Fiscal Year: 2013
    ..Lessons learned from lymphocytic choriomeningitis virus (LCMV) are applied to Lassa fever virus (LASV)...
  10. Mechanisms of CD8+ T Cell Apoptosis During Acute and Chronic Viral Infections
    JASON MITCHELL GRAYSON; Fiscal Year: 2010
    ..one death receptor results in delayed contraction of antigen-specific CD8+ T cells following acute lymphocytic choriomeningitis virus (LCMV) infection but cell numbers eventually decline...
  11. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..In response to hematopoietic stress induced by lymphocytic choriomeningitis virus (LCMV) infection or chemotherapy, Nlrp1aQ593P/Q593P mice fail to repopulate myeloid, lymphoid and ..
  12. Signaling and Metabolism in CD8 T cell Exhaustion During Chronic Infection
    MATTHEW MICHAL STARON; Fiscal Year: 2012
    ..virus (HIV), hepatitis C or B virus (HCV, HBV) and herpes viruses (CMV, EBV, HSV) in humans and lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl13) in mice, the virus is able to evade immune detection and can persist in a ..
  13. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael B Oldstone; Fiscal Year: 2013
    ..model for study, analysis and obtaining strategies to control persistent viral infections is lymphocytic choriomeningitis virus (LCMV) infection in it murine host...
  14. Type 1 IFN Function and Signaling in Immunity to Viruses
    CHRISTINE ANNE BIRON; Fiscal Year: 2013
    ..be advanced by studies of responses ex vivo following exposure to cytokines, and in vivo following lymphocytic choriomeningitis virus infections in wild type and genetically altered mice...
  15. GP130 Signaling During Chronic Virus Infection
    Elina I Zuniga; Fiscal Year: 2013
    ..We have therefore chosen to use chronic lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse, as a model system...
  16. RAS and injury: ACE and resistance to cancer and viral infection
    Kenneth E Bernstein; Fiscal Year: 2010
    ..We also studied the response of ACE 10/10 mice to infection by clone 13 of the lymphocytic choriomeningitis virus (LCMV). This stain of LCMV results in a chronic viral infection...
  17. The Role of Leukocyte Sequestration in the Control of Viral Infections
    John Altman; Fiscal Year: 2009
    ..Recently, we made the unexpected discovery that a strain of lymphocytic choriomeningitis virus (LCMV) that is normally rapidly cleared by immmunocompetent micethe Armstrong straininduces a ..
  18. Nedd4-family ubiquitination networks that regulate T cell function
    PAULA MARIA OLIVER; Fiscal Year: 2012
    ..To study whether Nedd4 is required for cell-mediated immune responses, we will use the Lymphocytic Choriomeningitis Virus (LCMV) infection model...
  19. Transcriptional regulation of CD8+ T cell differentiation
    Arnob Banerjee; Fiscal Year: 2013
    ..Eomes) and T-bet, develop an inappropriate effector CD8+ T cell response to acute infection with lymphocytic choriomeningitis virus (LCMV), fail to clear the infection, and die from inappropriate CD8+ T cell interleukin-17 secretion...
  20. Enhancement of HIV-specific CD4+ T cell function by blockade of the PD-1 pathway
    Brent Palmer; Fiscal Year: 2009
    ..of virus-specific CD8+ T cells both in subjects with chronic HIV infection and in mice infected with lymphocytic choriomeningitis virus (LCMV), a model system for T cell dysfunction induced by chronic viral infection...
  21. The Regulation of T Cell Exhaustion by Adhesion Molecules
    Allan J Zajac; Fiscal Year: 2013
    ..by applicant): During chronic infections such as those caused by HIV-1, hepatitis C virus, and lymphocytic choriomeningitis virus, as well as during tumor outgrowth, antigen-specific CD8 T cells often progressively lose function ..
  22. Inhibitory Pathways Underlying Viral Persistance in vivo
    Elina I Zuniga; Fiscal Year: 2013
    ..By using in vivo chronic lymphocytic choriomeningitis virus (LCMV) infection in mice, we recently found that specific and exclusive attenuation of TGF? ..
  23. Type 1 IFN Function and Signaling in Immunity to Viruses
    Christine Biron; Fiscal Year: 2009
    ..be advanced by studies of responses ex vivo following exposure to cytokines, and in vivo following lymphocytic choriomeningitis virus infections in wild type and genetically altered mice...
  24. CD4+ T cell affinity for self and foreign antigens in the CNS
    Brian D Evavold; Fiscal Year: 2013
    ..CD4+ T cells specific for self antigen myelin oligodendrocyte glycoprotein and pathogen associated lymphocytic choriomeningitis virus antigens...
  25. Regulation of chronic viral infection by co-inhibitory pathways
    Arlene H Sharpe; Fiscal Year: 2013
    ..We are using the lymphocytic choriomeningitis virus (LCMV) model to investigate how inhibitory pathways in the B7:CD28 family regulate T cell responses ..
  26. Structure and Function of MHC Proteins
    Lawrence J Stern; Fiscal Year: 2013
    ..The fifth aim is to characterize the structural basis for T cell crossreactivity of epitopes from vaccina virus and lymphocytic choriomeningitis virus.
  27. Mechanisms of Viral Persistence
    David G Brooks; Fiscal Year: 2013
    ..We discovered that infection with a persistent strain of lymphocytic choriomeningitis virus (LCMV) triggers high IL-10 production that directly ablates T cell function and causes viral ..
  28. Molecular basis of defective CD8 T cells during chronic viral infection
    Hao Shen; Fiscal Year: 2010
    ..Using infection of mice with lymphocytic choriomeningitis virus (LCMV) as a model, we have discovered that memory CD8 T cells generated in the absence of CD4 T cell ..
  29. Regulation of chronic viral infection by co-inhibitory pathways
    Arlene Sharpe; Fiscal Year: 2009
    ..During the current funding period, we have used the lymphocytic choriomeningitis virus (LCMV) model to investigate how inhibitory pathways in the B7:CD28 family regulate T cell responses ..
  30. Immune Regulation of Viral Persistence and Clearance
    David G Brooks; Fiscal Year: 2013
    ..To achieve this goal we will use the mouse model of lymphocytic choriomeningitis virus (LCMV) infection to explore virus-specific CD4 T helper differentiation during viral persistence and ..
  31. DELIVERY OF PROTEINS INTO CYTOSOL USING LLO-LIPOSOMES
    Kyung Dall Lee; Fiscal Year: 2002
    ..as a vaccine delivery vehicle, and will therefore be extended to a well-established mouse model of lymphocytic choriomeningitis virus (LCMV) infection...
  32. DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2009
    ..we will examine the mechanism of Spi2A upregulation in memory-cell precursors after infection with Lymphocytic choriomeningitis virus (LCMV)...
  33. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2001
    ..the role of TNF receptors (TNFRs) in regulating the generation of CD8+ memory T cells using the lymphocytic choriomeningitis virus (LCMV) model in mice...
  34. MUCOSAL INFECTION WITH ARENAVIRUS
    Igor Lukashevich; Fiscal Year: 2000
    ..The prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), has frequently been used to study cell-mediated immunity in inbred mice...
  35. RECOMBINANT L MONOCYTOGENES AS AN SIV VACCINE
    Andrew Kaplan; Fiscal Year: 2000
    ..has used this system to elicit protective immunity in three animal models of viral disease, lymphocytic choriomeningitis virus infection of mice as well as HTLV-1 and cottontail rabbit papilloma virus infection of rabbits...
  36. Mechanisms of CD4 T cell help for CD8 T cells during persistent viral infection
    Jeffrey Scott Hale; Fiscal Year: 2013
    ..The well- characterized lymphocytic choriomeningitis virus (LCMV) will be used to investigate the contribution of CD4 T cells following severe CD8 T cell ..
  37. REPLICATION AND SPREAD OF NEUROTROPIC VIRUSES
    Glenn Rall; Fiscal Year: 2001
    ..will be used to compare the outcome of neuronal infection caused by two neurotropic viruses, namely, lymphocytic choriomeningitis virus (LCMV) and measles virus (MV)...
  38. RECOMBINANT LISTERIA VACCINES FOR MELANOMA
    JEFFERY MILLER; Fiscal Year: 2003
    ..monocytogenes. Recombinant vaccine strains expressing the lymphocytic choriomeningitis virus (LCMV) nucleoprotein (NP), or a specific MHC class I restricted NP epitope, are able to induce LCMV ..
  39. The Role of Memory T-Cells in Pathogenesis
    JOSEPH KISSIL; Fiscal Year: 2009
    ..and modify the model to include two well-defined T cell epitopes (a CD4 and a CD8 epitope) from lymphocytic choriomeningitis virus (LCMV), GP33 and GP61, fused directly to the N-terminus of the oncogenic activated K-ras protein...
  40. 'ROLE OF SELF-PEPTIDES IN THE SELECTION OF T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2005
    ..which are recognized by CTLs specific for two different pathogenic viruses, Influenza (IF) and Lymphocytic Choriomeningitis virus (LCMV)...
  41. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..SIV infection, they can also cause disease by inducing immunopathology, as in certain instances of lymphocytic choriomeningitis virus infection in mice...
  42. MOLECULAR DETERMINANTS OF THE CYTOTOXIC T CELL RESPONSE
    Maria Salvato; Fiscal Year: 1992
    ..The studies proposed here will use laboratory mice infected with lymphocytic choriomeningitis virus (LCMV)...
  43. IL-1 dependent anorexia during CNS viral infection
    David Hildeman; Fiscal Year: 2007
    ..c.) lymphocytic choriomeningitis virus (LCMV) infection...
  44. Expansion of Rodent Biocontainment at the University of Missouri
    LONNY DIXON; Fiscal Year: 2009
    ..Biocontainment space is needed to safely study infectious organisms such as Streptococcus Group A, lymphocytic choriomeningitis virus, and Listeria monocytogenes, all of which can infect humans, causing such diseases as strep throat, ..
  45. Persistence of LCMV by exhaustion of antiviral T cells
    DIMITRIOS MOSKOFIDIS; Fiscal Year: 2006
    ..Viral persistence following infection with invasive strains of lymphocytic choriomeningitis virus (LCMV) can be achieved by selective down-regulation ("clonal exhaustion") of the virus-specific T ..
  46. CTL pathogenesis after infection of vaccinated host
    John Harty; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Perforin-mediated cytolysis is essential for clearance of lymphocytic choriomeningitis virus (LCMV) and perforin-deficient mice are models for familial hemophagocytic lymphohistiocytosis (FHL), a ..
  47. Cellular Immunology of Enterovirus Infection
    Paul Krogstad; Fiscal Year: 2007
    ..These experiments will employ recombinant CVB variants engineered to express lymphocytic choriomeningitis virus (LCMV) epitopes, and transgenic mice that express a specific LCMV specific TCR variant...
  48. EXERCISE INDUCED IMMUNOMODULATION IN AGING
    ZOHER KAPASI; Fiscal Year: 2000
    ..young and aged mice by evaluating the humoral and cell-mediated immune responses in a mouse model of lymphocytic choriomeningitis virus (LCMV) infection...
  49. Functional analyses of antiviral CD4+ T cell responses
    J Whitton; Fiscal Year: 2002
    ..they represent the two ends of the immunological spectrum; one induces strong CD8+ T cell responses [lymphocytic choriomeningitis virus (LCMV)], while the other induces strong CD4+ T cell/antibody responses [coxsackievirus B3 (CVB3)]...
  50. MIP1 ALPHA AND PROTECTIVE ANTIVIRAL IMMUNITY
    Daniel Quinn; Fiscal Year: 2003
    ..We are investigating the mechanisms of protective antiviral T cell responses using lymphocytic choriomeningitis virus (LCMV) infection of mice as a model system...
  51. Acquired susceptibility to pulmonary TB
    Hardy Kornfeld; Fiscal Year: 2009
    ..We discovered that infection of mice with lymphocytic choriomeningitis virus (LCMV), human pathogen, increases TB susceptibility and alters the pattern of immunopathology in the ..
  52. ROLE OF TYPE-I IFN'S IN ANTIVIRAL CD8 CELL RESPONSE
    Murali Krishna Kaja; Fiscal Year: 2007
    ..Our previous studies, using mouse models of lymphocytic choriomeningitis virus (LCMV) infection, demonstrated that acute viral infections induce a much higher magnitude of primary ..
  53. ADRENAL STEROID-IMMUNE INTERACTIONS IN VIRAL INFECTIONS
    Andrew Miller; Fiscal Year: 2002
    ..Finally, studies with MCMV and lymphocytic choriomeningitis virus (LCMV) clone E350 will be complemented by characterization of adrenal steroid-immune interactions in ..
  54. Dissection of the Anti-tumor Immune Response
    Erik Ranheim; Fiscal Year: 2006
    ..In addition, these tumors will express well characterized viral antigens from murine lymphocytic choriomeningitis virus, nucleoprotein (NP) and glycoprotein (GP) for use as model tumor antigens...
  55. TRANSGENIC MODELS OF VIRAL NEUROPATHY
    Michael Nerenberg; Fiscal Year: 1993
    ..Initial studies will utilize the lymphocytic choriomeningitis virus glycoprotein and nucleoprotein to investigate the mechanism of clearance of virus from neurons of ..
  56. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  57. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  58. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  59. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  60. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  61. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  62. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..