rna viruses

Summary

Summary: Viruses whose genetic material is RNA.

Top Publications

  1. pmc Metagenomic analysis of RNA viruses in a fresh water lake
    Appolinaire Djikeng
    Infectious Diseases Group, The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS ONE 4:e7264. 2009
  2. pmc Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
    Yueh Ming Loo
    Department of Immunology, University of Washington School of Medicine, Box 357650, Seattle, WA 98195 7650, USA
    J Virol 82:335-45. 2008
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
  4. ncbi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
  5. pmc Viral mutation rates
    Rafael Sanjuan
    Institut Cavanilles de Biodiversitat y Biologia Evolutiva, Departament de Genetica, Universitat de Valencia, C Catedrático Agustín Escardino 9, Paterna 46980, Valencia, Spain
    J Virol 84:9733-48. 2010
  6. pmc Subversion of cellular autophagosomal machinery by RNA viruses
    William T Jackson
    Department of Microbiology, Stanford University, Stanford, California, USA
    PLoS Biol 3:e156. 2005
  7. ncbi A metagenomic survey of microbes in honey bee colony collapse disorder
    Diana L Cox-Foster
    Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA
    Science 318:283-7. 2007
  8. pmc Non-canonical translation in RNA viruses
    Andrew E Firth
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Gen Virol 93:1385-409. 2012
  9. pmc Quasispecies theory and the behavior of RNA viruses
    Adam S Lauring
    Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 6:e1001005. 2010
  10. ncbi Mycoviruses of filamentous fungi and their relevance to plant pathology
    Michael N Pearson
    School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Mol Plant Pathol 10:115-28. 2009

Detail Information

Publications274 found, 100 shown here

  1. pmc Metagenomic analysis of RNA viruses in a fresh water lake
    Appolinaire Djikeng
    Infectious Diseases Group, The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS ONE 4:e7264. 2009
    ..Here we present a survey of RNA viruses in Lake Needwood, a freshwater lake in Maryland, USA...
  2. pmc Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
    Yueh Ming Loo
    Department of Immunology, University of Washington School of Medicine, Box 357650, Seattle, WA 98195 7650, USA
    J Virol 82:335-45. 2008
    ..RIG-I and MDA5 in pathogen recognition and innate immune signaling that may reflect unique and shared biologic properties of RNA viruses whose differential triggering and control of gene expression may impact pathogenesis and infection.
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
    ..In vitro studies suggest that both RIG-I and MDA5 detect RNA viruses and polyinosine-polycytidylic acid (poly(I:C)), a synthetic dsRNA analogue...
  4. ncbi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
    ..We review our current knowledge of the rates of mutation and substitution, as well as their determinants, in RNA viruses, DNA viruses and retroviruses...
  5. pmc Viral mutation rates
    Rafael Sanjuan
    Institut Cavanilles de Biodiversitat y Biologia Evolutiva, Departament de Genetica, Universitat de Valencia, C Catedrático Agustín Escardino 9, Paterna 46980, Valencia, Spain
    J Virol 84:9733-48. 2010
    ..The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between ..
  6. pmc Subversion of cellular autophagosomal machinery by RNA viruses
    William T Jackson
    Department of Microbiology, Stanford University, Stanford, California, USA
    PLoS Biol 3:e156. 2005
    ..Instead, we argue that these double-membraned structures provide membranous supports for viral RNA replication complexes, possibly enabling the nonlytic release of cytoplasmic contents, including progeny virions, from infected cells...
  7. ncbi A metagenomic survey of microbes in honey bee colony collapse disorder
    Diana L Cox-Foster
    Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA
    Science 318:283-7. 2007
    ..One organism, Israeli acute paralysis virus of bees, was strongly correlated with CCD...
  8. pmc Non-canonical translation in RNA viruses
    Andrew E Firth
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Gen Virol 93:1385-409. 2012
    ..Furthermore, whilst the great majority of cellular mRNAs are apparently monocistronic, RNA viruses must often express multiple proteins from their mRNAs...
  9. pmc Quasispecies theory and the behavior of RNA viruses
    Adam S Lauring
    Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 6:e1001005. 2010
    ..Here, we discuss basic principles of quasispecies theory and describe its relevance for our understanding of viral fitness, virulence, and antiviral therapeutic strategy...
  10. ncbi Mycoviruses of filamentous fungi and their relevance to plant pathology
    Michael N Pearson
    School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Mol Plant Pathol 10:115-28. 2009
    ....
  11. pmc IRGM is a common target of RNA viruses that subvert the autophagy network
    Isabel Pombo Gregoire
    Universite de Lyon, Lyon, France
    PLoS Pathog 7:e1002422. 2011
    ..We have determined the ability of 83 proteins of several families of RNA viruses (Paramyxoviridae, Flaviviridae, Orthomyxoviridae, Retroviridae and Togaviridae), to interact with 44 human ..
  12. pmc Viral genome sequencing by random priming methods
    Appolinaire Djikeng
    Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Genomics 9:5. 2008
    Most emerging health threats are of zoonotic origin. For the overwhelming majority, their causative agents are RNA viruses which include but are not limited to HIV, Influenza, SARS, Ebola, Dengue, and Hantavirus...
  13. pmc Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
    Poornima Parameswaran
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 6:e1000764. 2010
    ..These experiments define vsRNAs as one possible component of the interplay between animal viruses and their hosts...
  14. pmc Cis-acting RNA elements in human and animal plus-strand RNA viruses
    Ying Liu
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, USA
    Biochim Biophys Acta 1789:495-517. 2009
    The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions...
  15. ncbi TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
    Michaela U Gack
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
    Nature 446:916-920. 2007
    ..Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity...
  16. ncbi Bats as a continuing source of emerging infections in humans
    Samson Wong
    Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, 4 F University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Rev Med Virol 17:67-91. 2007
    Amongst the 60 viral species reported to be associated with bats, 59 are RNA viruses, which are potentially important in the generation of emerging and re-emerging infections in humans...
  17. pmc Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Virol 80:5059-64. 2006
    ..Surprisingly, however, no dsRNA signals were detected for negative-strand RNA viruses. Thus, dsRNA is indeed a general feature of most virus groups, but negative-strand RNA viruses appear to be an ..
  18. pmc Why do RNA viruses recombine?
    Etienne Simon-Loriere
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, USA
    Nat Rev Microbiol 9:617-26. 2011
    Recombination occurs in many RNA viruses and can be of major evolutionary significance. However, rates of recombination vary dramatically among RNA viruses, which can range from clonal to highly recombinogenic...
  19. ncbi Honey bee viruses
    Yan Ping Chen
    USDA ARS, Bee Research Laboratory, Beltsville, Maryland 20705, USA
    Adv Virus Res 70:33-80. 2007
    ..The chapter has been designed to provide researchers in the field with updated information about honey bee viruses and to serve as a starting point for future research...
  20. pmc Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses
    Man Yu
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, United States
    Cytokine Growth Factor Rev 22:63-72. 2011
    Double-stranded RNA (dsRNA), the genetic material for many RNA viruses, induces robust host immune responses via pattern recognition receptors, which include Toll-like receptor 3 (TLR3), retinoic acid-inducible gene-I-like receptors (..
  21. pmc Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, EH9 1QH
    RNA 10:1337-51. 2004
    ..genome-scale ordered RNA structure (GORS) in many genera and families of positive-strand animal and plant RNA viruses. There was remarkably variability between genera that possess this characteristic; for example, hepaciviruses ..
  22. pmc Widespread horizontal gene transfer from double-stranded RNA viruses to eukaryotic nuclear genomes
    Huiquan Liu
    College of Plant Science and Technology, Huazhong Agricultural University, Hubei Province, People s Republic of China
    J Virol 84:11876-87. 2010
    ..that horizontal transfer of double-stranded RNA viral genes is widespread among eukaryotes and may give rise to functionally important new genes, thus entailing that RNA viruses may play significant roles in the evolution of eukaryotes.
  23. ncbi Viruses of plant pathogenic fungi
    Said A Ghabrial
    Plant Pathology Department, University of Kentucky, Lexington, Kentucky 40546, USA
    Annu Rev Phytopathol 47:353-84. 2009
    ..The availability of viral and host genome sequences and of transformation and transfection protocols for some plant pathogenic fungi will contribute to progress in fungal virology...
  24. pmc Overlapping genes produce proteins with unusual sequence properties and offer insight into de novo protein creation
    Corinne Rancurel
    Architecture et Fonction des Macromolecules Biologiques, Case 932, Campus de Luminy, 13288 Marseille Cedex 9, France
    J Virol 83:10719-36. 2009
    ..the sequences of the protein products of manually curated overlapping genes from 43 genera of unspliced RNA viruses infecting eukaryotes...
  25. pmc RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study
    Maria Mathisen
    Centre for International Health, University of Bergen, PO Box 7804, N 5020 Bergen, Norway
    BMC Med 7:35. 2009
    ..Pneumonia is among the main causes of illness and death in children <5 years of age. There is a need to better describe the epidemiology of viral community-acquired pneumonia (CAP) in developing countries...
  26. pmc Prevalence and seasonal variations of six bee viruses in Apis mellifera L. and Varroa destructor mite populations in France
    Diana Tentcheva
    Laboratoire de Pathologie Comparée des Invertébrés UMR5087, CC 101, Universite Montpellier II, Montpellier, France
    Appl Environ Microbiol 70:7185-91. 2004
    ....
  27. ncbi The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    Tiejun Zhao
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Nat Immunol 8:592-600. 2007
    ..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways...
  28. ncbi Global honey bee viral landscape altered by a parasitic mite
    Stephen J Martin
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Science 336:1304-6. 2012
    ..Therefore, the global spread of Varroa has selected DWV variants that have emerged to allow it to become one of the most widely distributed and contagious insect viruses on the planet...
  29. pmc Metagenomic analysis of the turkey gut RNA virus community
    J Michael Day
    Southeast Poultry Research Laboratory Agricultural Research Service United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA
    Virol J 7:313. 2010
    ..Our analysis of this turkey gut RNA metagenome focuses in particular on the turkey-origin members of the Picornavirales, the Caliciviridae, and the turkey Picobirnaviruses...
  30. ncbi Southern tomato virus: The link between the families Totiviridae and Partitiviridae
    Sead Sabanadzovic
    Department of Entomology and Plant Pathology, Mississippi State University, MS 39762, USA
    Virus Res 140:130-7. 2009
    ..Phylogenetic analyses revealed that this virus, for which the name Southern tomato virus (STV) is proposed, belongs to a partitivirus-like lineage and represents a species of a new taxon of plant viruses...
  31. ncbi End-to-end communication in the modulation of translation by mammalian RNA viruses
    Dianna Edgil
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Virus Res 119:43-51. 2006
    ..Mammalian RNA viruses make use of end-to-end communication in conjunction with both viral and cellular factors to regulate multiple ..
  32. ncbi Plant-feeding insects harbor double-stranded RNA viruses encoding a novel proline-alanine rich protein and a polymerase distantly related to that of fungal viruses
    Allyn Spear
    United States Department of Agriculture Agricultural Research Service, San Joaquin Valley Agricultural Sciences Center, Parlier, CA 93648, USA
    Virology 404:304-11. 2010
    ....
  33. ncbi Viral error catastrophe by mutagenic nucleosides
    Jon P Anderson
    The Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 58:183-205. 2004
    ..Recent experiments with mutagenic nucleoside analogs validate this new approach to treating infection of RNA viruses. Lethal mutagenesis with HIV-infected cells in culture has been documented and has been postulated to be the ..
  34. ncbi Blueberry latent virus: an amalgam of the Partitiviridae and Totiviridae
    Robert R Martin
    Horticultural Crops Research Laboratory, USDA ARS, Corvallis, OR 97330, USA
    Virus Res 155:175-80. 2011
    ....
  35. pmc Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase
    Jean François Gélinas
    Virus Cell Interactions Laboratory, Lady Davis Institute for Medical Research, 3999 Cote Ste Catherine, Montreal, QC, H3T 1E2 Canada
    J Virol 85:8460-6. 2011
    ..to have an antiviral role, but recent studies have demonstrated that it promotes the replication of many RNA viruses. The data from these experiments show that ADAR1 directly enhances replication of hepatitis delta virus, human ..
  36. pmc Widespread endogenization of genome sequences of non-retroviral RNA viruses into plant genomes
    Sotaro Chiba
    Institute of Plant Science and Resources, Okayama University, Kurashiki, Japan
    PLoS Pathog 7:e1002146. 2011
    ..Here we report similarly endogenized NRVSs derived from plus-, negative-, and double-stranded RNA viruses in plant chromosomes...
  37. ncbi A novel monopartite dsRNA virus from rhododendron
    S Sabanadzovic
    Department of Entomology and Plant Pathology, Mississippi State University, MS 39762, USA
    Arch Virol 155:1859-63. 2010
    ..RhVA likely belongs to a yet-to-be-established taxon of viruses with a non-segmented dsRNA genome...
  38. pmc Identification of novel positive-strand RNA viruses by metagenomic analysis of archaea-dominated Yellowstone hot springs
    Benjamin Bolduc
    Thermal Biology Institute, Montana State University, Bozeman, Montana, USA
    J Virol 86:5562-73. 2012
    There are no known RNA viruses that infect Archaea...
  39. pmc Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections
    Haijing Li
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 45:2105-9. 2007
    ..The multiplex approach enhances diagnosis through detection of respiratory viral etiologic agents in cases in which the presence of the agent was not suspected and a test was not ordered by the clinicians...
  40. pmc Antiviral immunity in drosophila
    Cordula Kemp
    CNRS UPR, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Curr Opin Immunol 21:3-9. 2009
    ..In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals...
  41. ncbi RNA virus mutations and fitness for survival
    E Domingo
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Annu Rev Microbiol 51:151-78. 1997
    b>RNA viruses exploit all known mechanisms of genetic variation to ensure their survival. Distinctive features of RNA virus replication include high mutation rates, high yields, and short replication times...
  42. pmc Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs
    Qingfa Wu
    Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 107:1606-11. 2010
    ..We propose that invertebrate viruses discovered by this approach may include previously undescribed human and vertebrate viral pathogens that are transmitted by arthropod vectors...
  43. pmc Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.)
    Gaetana Lanzi
    Reparto di Biologia Moleculare, Istituto Zooprofilattico Sperimentale Lombardia e Emilia Romagna, Brescia, Italy 25124 I
    J Virol 80:4998-5009. 2006
    ..The genome organization, capsid morphology, and sequence comparison data indicate that DWV is a member of the recently established genus Iflavirus...
  44. pmc Rapid identification of known and new RNA viruses from animal tissues
    Joseph G Victoria
    Department of Molecular Virology, Blood Systems Research Institute, San Francisco, California, USA
    PLoS Pathog 4:e1000163. 2008
    ..We demonstrate that a simple, inexpensive, and rapid metagenomics approach is effective for identifying known and highly divergent new viruses in homogenized tissues of acutely infected mice...
  45. pmc RNA viruses in hymenopteran pollinators: evidence of inter-Taxa virus transmission via pollen and potential impact on non-Apis hymenopteran species
    Rajwinder Singh
    Department of Entomology, The Pennsylvania State University, Pennsylvania, United States of America
    PLoS ONE 5:e14357. 2010
    ..Among honey bee pathogens, RNA viruses are emerging as a serious threat and are suspected as major contributors to CCD...
  46. ncbi A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes
    Kousuke Hanada
    Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Japan
    Mol Biol Evol 21:1074-80. 2004
    b>RNA viruses successfully adapt to various environments by repeatedly producing new mutants, often through generating a number of nucleotide substitutions...
  47. ncbi The role of varroa mites in infections of Kashmir bee virus (KBV) and deformed wing virus (DWV) in honey bees
    Miaoqing Shen
    Department of Entomology, The Pennsylvania State University, 501 ASI Building, University Park, PA 16802, USA
    Virology 342:141-9. 2005
    ....
  48. pmc Hijacking the translation apparatus by RNA viruses
    Martin Bushell
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA
    J Cell Biol 158:395-9. 2002
    ..Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first ..
  49. ncbi The extent of codon usage bias in human RNA viruses and its evolutionary origin
    Gareth M Jenkins
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Virus Res 92:1-7. 2003
    ..the results of a survey of codon usage bias in a wide range of genetically and ecologically diverse human RNA viruses. This analysis showed that the overall extent of codon usage bias in RNA viruses is low and that there is ..
  50. ncbi Wolbachia and virus protection in insects
    Lauren M Hedges
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 322:702. 2008
    ..Drosophila melanogaster flies infected with Wolbachia are less susceptible to mortality induced by a range of RNA viruses. The antiviral protection associated with Wolbachia infection might be exploited in future strategies to reduce ..
  51. pmc In vivo delivery of cytoplasmic RNA virus-derived miRNAs
    Ryan A Langlois
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Ther 20:367-75. 2012
    ..Taken together, these results validate noncanonical processing of cytoplasmic-derived miRNAs and provide a novel platform for small RNA delivery...
  52. ncbi Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference
    Linda Hüsser
    Institute of Virology and Immunoprophylaxis IVI, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    Virus Res 159:9-16. 2011
    ....
  53. ncbi Translation initiation factors: a weak link in plant RNA virus infection
    Christophe Robaglia
    Laboratoire de Genetique et Biophysique des Plantes, CEA CNRS Université Aix Marseille II, Faculte des Sciences de Luminy, F 13009 Marseille, France
    Trends Plant Sci 11:40-5. 2006
    ..Their role in plant resistance against RNA viruses remains to be elucidated...
  54. pmc Muco-cutaneous leishmaniasis in the New World: the ultimate subversion
    Catherine Ronet
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Virulence 2:547-52. 2011
    ..The presence of LRV in Leishmania opens new perspectives not only in basic understanding of the intimate relation between the parasite and LRV, but also in understanding the importance of the inflammatory response in MCL patients...
  55. ncbi A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication
    Christopher Netherton
    Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
    Adv Virus Res 70:101-82. 2007
    ....
  56. ncbi A multipartite single-stranded negative-sense RNA virus is the putative agent of fig mosaic disease
    Toufic Elbeaino
    Istituto Agronomico Mediterraneo di Bari, Via Ceglie 9, 70010 Valenzano, Italy
    J Gen Virol 90:1281-8. 2009
    ..homology with the polymerase and the putative glycoprotein precursor genes of negative-sense single-stranded RNA viruses of the family Bunyaviridae...
  57. pmc RNA-based viral immunity initiated by the Dicer family of host immune receptors
    Roghiyh Aliyari
    Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Immunol Rev 227:176-88. 2009
    ..Production of virus-derived small RNAs is undetectable in mammalian cells infected with RNA viruses. However, infection of mammals with several nucleus-replicating DNA viruses induces production of virus-derived ..
  58. ncbi The population genetics and evolutionary epidemiology of RNA viruses
    Andres Moya
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Apartado Postal 22085, 46071 Valencia, Spain
    Nat Rev Microbiol 2:279-88. 2004
  59. ncbi Selection pressures in the capsid genes of plant RNA viruses reflect mode of transmission
    Elizabeth R Chare
    Department of Zoology, Tinbergen Building, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Gen Virol 85:3149-57. 2004
    To determine the selection pressures faced by RNA viruses of plants, patterns of nonsynonymous (dN) and synonymous (dS) substitution in the capsid genes of 36 viruses with differing modes of transmission were analysed...
  60. ncbi Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter
    S Mehdi Belgnaoui
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Canada
    Curr Opin Immunol 23:564-72. 2011
    ..This review summarizes recent findings related to the MAVS adapter and its essential role in the innate immune response to RNA viruses.
  61. ncbi Dinucleotide and stop codon frequencies in single-stranded RNA viruses
    B K Rima
    School of Biology and Biochemistry, The Queen s University of Belfast, UK
    J Gen Virol 78:2859-70. 1997
    ..The UAG codon appeared more common in the +1 frame, the UGA in the -1 frame...
  62. ncbi Three-dimensional structure of penicillium chrysogenum virus: a double-stranded RNA virus with a genuine T=1 capsid
    José R Castón
    Department of Estructura de Macromoléculas, Centro Nacional de Biotecnologi a, CSIC, Campus Universidad Autonoma de Madrid, 28049, Madrid, Spain
    J Mol Biol 331:417-31. 2003
    Although double-stranded (ds) RNA viruses are a rather diverse group, they share general architectural principles and numerous functional features...
  63. pmc Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR
    Christian Drosten
    Bernhard Nocht Institute of Tropical Medicine, Hamburg, Germany
    J Clin Microbiol 40:2323-30. 2002
    ..6 to 16 RNA copies per assay). The suitability of the assays was exemplified by detection and quantification of viral RNA in serum samples of VHF patients...
  64. pmc Multiplex reverse transcription PCR Luminex assay for detection and quantitation of viral agents of gastroenteritis
    Jie Liu
    Divisions of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Clin Virol 50:308-13. 2011
    ..Several viruses can cause diarrheal disease, a leading cause of morbidity and mortality worldwide. Existing diagnostic methods include ELISA and nucleic acid amplification, usually performed individually...
  65. ncbi Red queen dynamics, competition and critical points in a model of RNA virus quasispecies
    R V Solé
    Complex Systems Research Group, Department of Physics, FEN, Universitat Politecnica de Catalunya, Campus Nord B4, 08034 Barcelona, Spain
    J Theor Biol 198:47-59. 1999
    b>RNA viruses offer a unique opportunity for the study of evolution at the molecular level...
  66. ncbi Mimicry of molecular pretenders: the terminal structures of satellites associated with plant RNA viruses
    Ying Wen Huang
    Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan
    RNA Biol 7:162-71. 2010
    ....
  67. pmc Family level phylogenies reveal modes of macroevolution in RNA viruses
    Andrew Kitchen
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 108:238-43. 2011
    Despite advances in understanding the patterns and processes of microevolution in RNA viruses, little is known about the determinants of viral diversification at the macroevolutionary scale...
  68. pmc Mutation rates among RNA viruses
    J W Drake
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Proc Natl Acad Sci U S A 96:13910-3. 1999
    ..A previous analysis of mutation rates in RNA viruses (specifically in riboviruses rather than retroviruses) was constrained by the quality and quantity of available ..
  69. pmc Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays
    Jeannie F Spagnolo
    1Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    RNA 16:382-93. 2010
    Few antivirals are effective against positive-strand RNA viruses, primarily because the high error rate during replication of these viruses leads to the rapid development of drug resistance...
  70. pmc Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanism
    Mikhail V Schepetilnikov
    Department of Botany and Plant Pathology, Oregon State University, Cordley Hall 2082, Corvallis, OR 97331, USA
    J Virol 82:1284-93. 2008
    ..The determinants of targeting to plasmodesmata were localized to the C-terminal region of TGBp3, including the conserved hydrophilic and terminal membrane-spanning domains...
  71. pmc Estrogen inhibits dendritic cell maturation to RNA viruses
    Maria M Escribese
    Department of Microbiology, The Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 112:4574-84. 2008
    ..Using this system, we demonstrated that E2 pretreatment down-regulated the antiviral response to RNA viruses in DCs by profoundly suppressing type I interferon (IFN) synthesis and other important inflammatory products...
  72. ncbi The evolutionary genetics of emerging plant RNA viruses
    Santiago F Elena
    Instituto de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Valencia, Spain
    Mol Plant Microbe Interact 24:287-93. 2011
    ..The present review puts emergence of plant RNA viruses into the framework of evolutionary genetics, stressing that viral emergence begins with a stochastic process ..
  73. ncbi Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
    ..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also...
  74. ncbi Aggresomes and autophagy generate sites for virus replication
    Thomas Wileman
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Science 312:875-8. 2006
    ..Here I review the evidence that some viruses induce aggresomes and autophagosomes to generate sites of replication...
  75. ncbi A molecular target for viral killer toxin: TOK1 potassium channels
    A Ahmed
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Cell 99:283-91. 1999
    Killer strains of S. cerevisiae harbor double-stranded RNA viruses and secrete protein toxins that kill virus-free cells. The K1 killer toxin acts on sensitive yeast cells to perturb potassium homeostasis and cause cell death...
  76. pmc Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses
    V Bitko
    Department of Biochemistry and Molecular Biology MSB 2370, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, AL 36688 0002, USA
    BMC Microbiol 1:34. 2001
    ..Since directed mutation of RNA genomes is not possible through conventional mutagenesis, we have tested sequence-specific 21-nucleotide long double-stranded RNAs (dsRNAs) for their ability to silence cytoplasmic RNA genomes...
  77. ncbi Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies
    Jonathan Moore
    Warwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, UK
    J Gen Virol 92:156-61. 2011
    ..destructor and honeybees than the parental DWV or a recombinant bearing the VDV-1-derived 5'-UTR (VDV-1(VVD))...
  78. ncbi Horizontal transmission of deformed wing virus: pathological consequences in adult bees (Apis mellifera) depend on the transmission route
    Nadine Möckel
    Institute for Bee Research, Friedrich Engels Str 32, D 16540 Hohen Neuendorf, Germany
    J Gen Virol 92:370-7. 2011
    ..Therefore, both infection of adult bees through DWV-transmitting phoretic mites and infection of nurse bees through their cannibalizing DWV-infected pupae might represent possible horizontal transmission routes of DWV...
  79. pmc A sensitive, specific, and cost-effective multiplex reverse transcriptase-PCR assay for the detection of seven common respiratory viruses in respiratory samples
    Melanie W Syrmis
    Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital and Health Service District, Queensland, Australia
    J Mol Diagn 6:125-31. 2004
    ..polymerase chain reaction (m-RT-PCR) is a sensitive, specific, and rapid method for detecting several DNA and RNA viruses in a single specimen...
  80. ncbi Molecular characterisation and phylogenetic analysis of Chronic bee paralysis virus, a honey bee virus
    Violaine Olivier
    Agence Francaise de Securite Sanitaire des Aliments, 105 route des Chappes, BP 111, 06 902 Sophia Antipolis, France
    Virus Res 132:59-68. 2008
    ..However, no similarities were found between the other CBPV deduced amino acid sequences and sequences in the NCBI databases, suggesting that CBPV is the prototype of a new family of positive single-stranded RNA viruses.
  81. ncbi Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses
    Elizabeth R Chare
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Gen Virol 84:2691-703. 2003
    Recombination is increasingly seen as an important means of shaping genetic diversity in RNA viruses. However, observed recombination frequencies vary widely among those viruses studied to date, with only sporadic occurrences reported in ..
  82. pmc Microarray-based detection and genotyping of viral pathogens
    David Wang
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15687-92. 2002
    ..This method is versatile and greatly expands the spectrum of detectable viruses in a single assay while simultaneously providing the capability to discriminate among viral subtypes...
  83. ncbi Unifying the epidemiological and evolutionary dynamics of pathogens
    Bryan T Grenfell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Science 303:327-32. 2004
    ..of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates...
  84. ncbi Nidovirales: evolving the largest RNA virus genome
    Alexander E Gorbalenya
    Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, LUMC E4 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Virus Res 117:17-37. 2006
    This review focuses on the monophyletic group of animal RNA viruses united in the order Nidovirales...
  85. pmc Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system
    Benjamin D Greenbaum
    Institute for Advanced Study, Princeton, New Jersey, United States of America
    PLoS ONE 4:e5969. 2009
    ..This shows how differences in host immune biology can drive the evolution of viruses that jump into species with different immune priorities than the original host...
  86. ncbi Biological control of chestnut blight with hypovirulence: a critical analysis
    Michael G Milgroom
    Department of Plant Pathology, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Phytopathol 42:311-38. 2004
    ..Overall, however, not enough is understood about the epidemiological dynamics of this system to determine the crucial factors regulating the establishment of hypovirulence in chestnut forests...
  87. ncbi Functional analysis of structural motifs in dicistroviruses
    Nobuhiko Nakashima
    National Institute of Agrobiological Sciences, Owashi 1 2, Tsukuba, Ibaraki 305 8634, Japan
    Virus Res 139:137-47. 2009
    The family Dicistroviridae is composed of positive-stranded RNA viruses which have monopartite genomes. These viruses carry genome-linked virus proteins (VPg) and poly (A) tails...
  88. pmc Isolation and characterization of a single-stranded RNA virus infecting the bloom-forming diatom Chaetoceros socialis
    Yuji Tomaru
    National Research Institute of Fisheries and Environment of Inland Sea, Fisheries Research Agency, 2 17 5 Maruishi, Hatsukaichi, Hiroshima 739 0452, Japan
    Appl Environ Microbiol 75:2375-81. 2009
    ..The monophyly of CsfrRNAV and other diatom-infecting RNA viruses, Rhizosolenia setigera RNA virus and Chaetoceros tenuissimus RNA virus, was strongly supported by phylogenetic ..
  89. ncbi Vertical-transmission routes for deformed wing virus of honeybees (Apis mellifera)
    Constanze Yue
    Institute for Bee Research, Friedrich Engels Str 32, D 16540 Hohen Neuendorf, Germany
    J Gen Virol 88:2329-36. 2007
    ..Viral sequences in fertilized eggs can originate from the queen, as well as from drones via DWV-positive semen...
  90. pmc Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses
    Eugenie Hebrard
    UMR 1097 Résistance des Plantes aux Bio agresseurs, IRD, CIRAD, Universite de Montpellier II, BP 64501, 34394 Montpellier Cedex 5, France
    Virol J 6:23. 2009
    ..To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins...
  91. ncbi The adaptation of Rice yellow mottle virus to the eIF(iso)4G-mediated rice resistance
    Oumar Traore
    Institut de l Environnement et de Recherches Agricoles, Ouagadougou, Burkina Faso
    Virology 408:103-8. 2010
    ..Comparison with the RB process of rymv1-2, a resistance allele found in a few Oryza sativa cultivars, showed similarities in the mode of adaptation but revealed converse virulence specificity of the isolates...
  92. ncbi Nucleo-cytoplasmic shuttling of the beet necrotic yellow vein virus RNA-3-encoded p25 protein
    Guillaume Vetter
    Departement de Virologie, Institut de Biologie Moleculaire des Plantes du CNRS, 12 rue du Général Zimmer, 67084 Strasbourg, France
    J Gen Virol 85:2459-69. 2004
    ..Studies with mutated derivatives of GFP-p25 revealed that symptom phenotype was altered when the subcellular localization of GFP-p25 was modified...
  93. ncbi The nucleotide sequence and genome organization of Sclerophthora macrospora virus A
    Toshiro Yokoi
    Laboratory of Plant Pathology, Department of Agricultural and Environmental Biology, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Virology 311:394-9. 2003
    ..The deduced amino acid sequence of ORF 1a shows some similarity to those of RdRp of certain positive-strand RNA viruses, especially to the members of the family Nodaviridae, and that of ORF 2 to CP of the members in the family ..
  94. ncbi Reverse genetics of negative-stranded RNA viruses: a global perspective
    Pramila Walpita
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    FEMS Microbiol Lett 244:9-18. 2005
    The advent of reverse genetics technology has revolutionized the field of RNA viruses. It is now possible to manipulate even negative-stranded RNA viruses at will, and evaluate the effects of these changes on the biology and pathogenesis ..
  95. ncbi Single-stranded RNA viruses inactivate the transcriptional activity of p53 but induce NOXA-dependent apoptosis via post-translational modifications of IRF-1, IRF-3 and CREB
    C Lallemand
    Laboratory of Viral Oncology, UPR CNRS 9045, Institut Andre Lwoff, Villejuif, France
    Oncogene 26:328-38. 2007
    ..In addition transactivation induced by IRF-1 during viral infection correlates with a 10 kDa increase in its molecular weight, suggesting a covalent linkage with a previously unknown regulatory polypeptide...
  96. pmc Induction of type I interferon by RNA viruses: cellular receptors and their substrates
    Alina Baum
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Amino Acids 38:1283-99. 2010
    ..We highlight the roles of TRL3, TLR7/8, retinoic acid inducible gene I, melanoma differentiation-associated gene 5, and the RNA molecules responsible for activating these viral sensors...
  97. pmc Deep sequencing evidence from single grapevine plants reveals a virome dominated by mycoviruses
    M Al Rwahnih
    Department of Plant Pathology, University of California, Davis, California, 1 Shields Avenue, Davis, CA 95616, USA
    Arch Virol 156:397-403. 2011
    ..Five of the mycoviruses identified in the total grapevine extract were identified again in extracts of the fungal cultures...
  98. ncbi Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus
    Atif Jamal
    Division of Biology, Faculty of Natural Sciences Imperial College London, Sir Alexander Fleming Building, Imperial College Road, London SW7 2AZ, United Kingdom
    Virus Res 153:64-70. 2010
    ..The dsRNA profile, amino acid sequence alignments, and phylogenetic analyses all indicate that AfuCV is a new species within the family Chrysoviridae...
  99. ncbi How RNA viruses maintain their genome integrity
    John N Barr
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
    J Gen Virol 91:1373-87. 2010
    ..to coding regions and loss of critical cis-acting signals inevitably impair genome fitness; as a consequence, RNA viruses have evolved a variety of mechanisms to protect their genome integrity...
  100. ncbi Simple quasispecies models for the survival-of-the-flattest effect: The role of space
    Josep Sardanyés
    Complex Systems Lab ICREA UPF, Barcelona Biomedical Research Park PRBB GRIB, Dr Aiguader 88, 08003 Barcelona, Spain
    J Theor Biol 250:560-8. 2008
    ..Furthermore, it is shown that space, which involves a lower critical mutation rate, broadens the conditions at which the survival-of-the-flattest may occur...
  101. ncbi Effect of lethality on the extinction and on the error threshold of quasispecies
    Hector Tejero
    Departamento de Bioquimica y Biologia Molecular I, Universidad Complutense de Madrid, Avd Complutense s n, 28040 Madrid, Spain
    J Theor Biol 262:733-41. 2010
    ....

Research Grants73

  1. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..Aim 2, we will extend these studies to determine if our preliminary results apply to other clinically-relevant RNA viruses such as respiratory syncytial virus, human parainfluenza virus, human metapneumovirus, influenza virus, and ..
  2. Thirteenth Annual Meeting of the Rocky Mountain Virology Association
    Joel Rovnak; Fiscal Year: 2013
    ..topics discussed include medical virology (vaccines, epidemiology, viral zoonoses), arthropod-borne diseases (RNA viruses and RNA metabolism, viral vectors and vector biology), host defenses (viral immunology and pathogenesis), ..
  3. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..a novel subpopulation of alveolar epithelial Type II cells that selectively expresses genes that destroy RNA viruses and bacteria, and control asymmetric cell division of stem/progenitor cells...
  4. Immune Regulation of Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2012
    ..Indeed, a vital local protective role of ASC is supported by other experimental CNS infections, particularly by RNA viruses such as Sindbis, Semliki Forest, and Rabies viruses...
  5. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as HIV and West Nile, and in heritable mutations of ubiquitously expressed genes such as SOD1...
  6. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that cause hemorrhagic fevers (VHFs). Another agent of grave concern is influenza (Flu) (Category "C")...
  7. Cellular Components Involved in Japanese Encephalitis Virus Entry
    Young Min Lee; Fiscal Year: 2013
    ..the subsequent post-entry steps;this cell line remains highly susceptible to infection by two other enveloped RNA viruses which, like JEV, enter the cells through clathrin-dependent endocytic pathway...
  8. Coronavirus modulation of cellular microRNAs in the liver: role in hepatitis
    Sonia Navas-Martin; Fiscal Year: 2012
    ..We have investigated whether coronaviruses (CoVs), a group of emerging animal and human RNA viruses, may have the ability to modulate the expression of some cellular miRNAs, which may determine disease outcome...
  9. Role of microRNAs in Coronavirus-induced lethal encephalitis
    Sonia Navas-Martin; Fiscal Year: 2012
    ..Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded, polyadenylated RNA viruses. Different murine CoVs (Mouse Hepatitis Virus, MHV) isolates induce acute lethal encephalitis and ..
  10. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    ..In addition, due to the mutation rate of RNA viruses, it is essential to identify conserved virus specific mechanisms, involving only viral components, which are ..
  11. Fatty Acid Synthase Inhibitors As Broad Spectrum Anti-Flaviviral Therapeutics
    Glenn Randall; Fiscal Year: 2013
    ..As with other positive stranded RNA viruses, DENV rearranges cellular membranes to establish unique cytosolic structures that are the sites of replication ..
  12. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The genomes of many positive sense RNA viruses contain an internal ribosomal entry site (IRES) that mediates end-independent initiation of translation...
  13. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2013
    ..Coronaviruses are positive strand RNA viruses which cause a range of illness, from relatively mild respiratory disease (croup and common cold like symptoms ..
  14. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..helicase inhibitors that target DNA viruses are progressing in clinical trials, no antiviral agents targeting RNA viruses have entered the clinical arena...
  15. Identification and characterization of inhibitors for hantavirus replication
    MOHAMMAD AYOUB MIR; Fiscal Year: 2013
    ..provided by applicant): Hantaviruses, members of the Bunyaviridae family are negative stranded emerging RNA viruses and category A pathogens that cause serious illness when transmitted to humans through aerosolized excreta of ..
  16. Determinants of Coronavirus Fidelity in Replication and Pathogenesis
    Mark R Denison; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Emerging human and zoonotic RNA viruses including SARS-CoV cause significant global morbidity, mortality, and social disruption...
  17. MOLECULAR BASIS OF ALPHAVIRUS ASSEMBLY
    Richard J Kuhn; Fiscal Year: 2013
    ..provided by applicant): Alphaviruses are a group of arthropod-transmitted, enveloped, positive-strand RNA viruses classified in the Togaviridae family...
  18. Theiler's virus-induced aoptosis: A mechanism for CNS virus persistence
    HOWARD LEE LIPTON; Fiscal Year: 2013
    ..In contrast to persistence of non-cytolytic RNA viruses in which the host cell survives, persistence of lytic RNA viruses in which an infected cell dies requires ..
  19. STRUCTURE AND FUNCTION OF NUCLEIC ACIDS
    Ignacio Tinoco; Fiscal Year: 2013
    ..Messenger RNAs transfer the genetic information from DNA to proteins;in RNA viruses the RNA is both the genetic information, and the messenger for protein synthesis...
  20. The Pox Virion Molecular Interactome
    Paul D Gershon; Fiscal Year: 2013
    ..the pox virion core wall may not be fundamentally dissimilar to the matrix protein layers of some enveloped RNA viruses, and that the classical delineation of enzymes in the deep interior with structural proteins surrounding may ..
  21. Mechanisms of blood-brain barrier disruption by an encephalitic virus
    Katherine R Spindler; Fiscal Year: 2013
    ..Members of at least eleven virus families cause encephalitis, including DNA viruses, retroviruses and RNA viruses, with significant morbidity and mortality...
  22. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2010
    ..Evolution of plus- stranded RNA viruses is frequently driven by RNA recombination, a process that joins noncontiguous RNA segments together, creating ..
  23. Improved idiotype immunotherapy for lymphoma by RNA vaccine delivery
    ALISON ANNE MCCORMICK; Fiscal Year: 2010
    ..R21 application seeks to implement improved cancer vaccine characteristics by harnessing innate immunity to RNA viruses. Our hypothesis is that encapsidated RNA vaccines that express non-Hodgkin's lymphoma tumor antigens will ..
  24. Forms of HCV NS5A in vivo
    Craig E Cameron; Fiscal Year: 2013
    ..HCV non-structural protein 5A (NS5A) is unique among non-structural proteins of most positive-strand RNA viruses. Two of its three domains are intrinsically disordered, and it contains numerous sites of phosphorylation for ..
  25. Astrovirus structure and replication
    Yizhi Jane Tao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Astroviruses are small, non-enveloped, positive-sense RNA viruses that infect humans, mammals and birds, posing a serious threat to human health and the well being of wild animals and economically ..
  26. MOLECULAR MECHANISMS OF ALPHAVIRUS ENTRY AND EXIT
    Margaret Kielian; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alphaviruses and flaviviruses are small enveloped plus-sense RNA viruses with structurally and functionally-related membrane fusion proteins...
  27. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    Human coronaviruses (HCoVs) are positive-stranded RNA viruses that are estimated to account for approximately 30% of cases of the common cold...
  28. Functions of 5'NCRs of picornavirus and cellular mRNAs
    Bert L Semler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Picornaviruses as well as other positive strand RNA viruses utilize sequences in the 5'noncoding regions (5'NCRs) of their genomic RNAs to bind host cell and viral proteins to carry out ..
  29. POLYMERASE PROTEINS IN CORONAVIRUS REPLICATION
    Mark R Denison; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Replication of positive-strand RNA viruses requires processing of virus-encoded polyproteins by viral proteases...
  30. Control of cap-independent translation by a viral 3'UTR
    WYATT ALLEN MILLER; Fiscal Year: 2013
    ..In contrast, the RNAs of most RNA viruses are uncapped, so they have evolved RNA structures that recruit the ribosome by noncanonical, cap-independent ..
  31. Reverse genetics to develop a second generation Rift Valley fever vaccine
    Tetsuro Ikegami; Fiscal Year: 2013
    ..My long term goal is to establish effective countermeasures against highly virulent negative-stranded RNA viruses, with special emphasis on vaccination...
  32. Structural Studies of Alphavirus Membrane Fusion In Situ
    Wei Zhang; Fiscal Year: 2010
    The Alphaviruses are enveloped, plus strand RNA viruses within the Togaviridae family, and are important human and animal pathogens. These viruses invade the host cells through the receptor-mediated endocytosis pathway...
  33. Assembly dynamics and role of PI4P enriched replication organelles for enterovira
    Ann Cali; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cells infected with plus-strand RNA viruses undergo dramatic remodeling of their intracellular membranes into so-called replication organelles...
  34. Interconnectivity between genome packagaing and other viral functions
    A L Rao; Fiscal Year: 2010
    ..provided by applicant): Information gleaned from recent studies with single-stranded, positive-sense RNA viruses pathogenic to humans and animals (polio and alphaviruses) and insects (flock house virus;FHV) revealed that the ..
  35. Preclinical Development of m102.4, a Human Anti-Hendra and Nipah Antibody
    Timothy R Fouts; Fiscal Year: 2013
    ..They are enveloped, negative-sense RNA viruses that cause a systemic and fatal disease in a variety of animal hosts and in humans...
  36. Reconstitution of Poliovirus and HCV RNA Replication Complexes on Membranes
    JENNIFER BARBARA PTACEK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): It has been well established that all positive-strand RNA viruses of eukaryotic cells, including poliovirus and hepatitis C virus (HCV), replicate their genomes on the cytosolic surface of membranous ..
  37. Mechanistic Studies of the Function of Desmosterol Homeostasis in HCV Replication
    VALERIE ANNE AGUSTINO VILLAREAL; Fiscal Year: 2013
    ..agents include the existence of multiple genotypes, low efficacy, and the characteristic high mutation rate of RNA viruses. While recently approved directly-acting viral inhibitors are expected to improve treatment efficacy, rapid ..
  38. A new synergy for flavivirus therapy: RNAi enhancement and viral mutagens
    KATHRYN ALYCE HANLEY; Fiscal Year: 2012
    ..provided by applicant): The genus Flavivirus, comprising 80 species of single-stranded, positive-sense RNA viruses, includes a large number of globally significant emerging pathogens...
  39. Membrane Hijacking: Biogenesis and Fate of Enveloped Hepatovirus
    Stanley M Lemon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Picornaviridae are a large and diverse family of positive-strand RNA viruses that include a number of important human pathogens, among them hepatitis A virus (HAV), an hepatotropic virus that is ..
  40. The roles of acidic autophagosomes in production of infectious poliovirus
    William T Jackson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): All positive strand RNA viruses studied to date rearranged cellular membranes to promote their own replication...
  41. Genetic Analysis of Molecular Interactions in Coronavirus Replication
    PAUL SCOTT MASTERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coronaviruses are a family of enveloped RNA viruses that cause respiratory, enteric, and neurologic diseases in mammalian and avian hosts...
  42. Metagenomic detection of emerging viruses in the blood supply
    Eric L Delwart; Fiscal Year: 2013
    ..new viruses and have used it to identify and characterize the full genomes of numerous human and animal DNA and RNA viruses. Purification of the nucleic acids within viral particles is followed first by their unbiased RNA and DNA ..
  43. Training in Hantavirus Ecology, Virology & Clinical Investigation in the Americas
    GREGORY JAMES MERTZ; Fiscal Year: 2010
    Hantaviruses are RNA viruses that are harbored by specific rodent species and are transmitted to man via inhalation of virus-contaminated rodent feces and urine...
  44. Genetic dissection of the RNAi-mediated antiviral immunity in C. elegans
    Shou Wei Ding; Fiscal Year: 2013
    ..The mammalian immune mechanisms that defend against RNA viruses are poorly characterized...
  45. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay W Black; Fiscal Year: 2013
    ..Common features are seen also in the packaging of many RNA viruses of clinical importance, such as Reoviruses...
  46. Defining the cis and trans acting factors required for assembly of infectious Blu
    Polly Roy; Fiscal Year: 2013
    ..genome packaging and replication events of this complex capsid virus and by inference for all multi-segmented RNA viruses. In specific aim 1 we will determine the packaging order of ten ssRNAs and the signals involved in assembly of ..
  47. Henipavirus Entry and Virion Assembly
    Christopher Broder; Fiscal Year: 2013
    ..in which to explore unanswered questions about these aspects of paramyxoviruses and negative-stranded enveloped RNA viruses in general...
  48. Mechanisms of RNA binding and remodeling proteins
    Kevin D Raney; Fiscal Year: 2012
    ..Many of these molecular motors are DEAD-box or closely related proteins. Positive strand RNA viruses such as the Hepatitis C virus (HCV) require the activity of these proteins for viral replication...
  49. Nikon A1RSI Confocal Microscope
    Sailen Barik; Fiscal Year: 2012
    ..clock location and function;Toxoplasma-host mitochondria interaction;Regulation of innate immunity by RNA viruses;Differentiation of megakaryocytes and pluripotent stem cells;Small RNA biogenesis and function...
  50. RNAi in DNA Sequence Elimination in Tetrahymena
    Martin A Gorovsky; Fiscal Year: 2010
    ..While this mechanism likely originated as a defense against invading RNA viruses and transposable elements, similar machineries are used in a variety of important cellular processes to produce ..
  51. Gene silencing as an antiviral defense in animal cells
    Shou Wei Ding; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): RNA viruses include important human pathogens such as hepatitis C, West Nile and dengue viruses and exhibit distinct genetic and immunological properties from DNA viruses...
  52. Viral Protein Determinants of Coronavirus Replication Fidelity
    Everett Clinton Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coronaviruses (CoVs) are a family of positive-stranded RNA viruses that cause respiratory disease in humans ranging in severity from the common cold to severe acute respiratory syndrome (SARS)...
  53. Viral Mediated Type I Interferon Induction
    Genhong Cheng; Fiscal Year: 2013
    ..signal transduction pathways lead to Interferon (IFN) induction in response to infections with DNA and RNA viruses. To combat viral infections most nucleated vertebrate cells are able to produce cytokines known as type I IFNs, ..
  54. Role of Lipids in Hepatitis C Virus Maturation
    Aleem Siddiqui; Fiscal Year: 2013
    ..These studies will reveal unique insights into the mechanisms of HCV maturation, secretion and budding processes and provide a unique model for other RNA viruses.
  55. RNA processing in non-segmented minus-strand RNA viruses
    Sean P J Whelan; Fiscal Year: 2013
    ..provided by applicant): This is an application to renew a grant to study RNA synthesis in minus-strand RNA viruses. Nonsegmented negative-strand (NNS) RNA viruses include some of the most significant human pathogens that are a ..
  56. Assays for Discovery of Translation Inhibitors
    Gerhard Wagner; Fiscal Year: 2009
    ..of the small molecule inhibitors proposed in this study will specifically modulate the synthesis of oncoproteins and protein from RNA viruses. The proposed study will allow us to obtain leads for anti-cancer and anti-viral drug design.
  57. Functional role of a host metabolic enzyme in viral replication
    Peter Nagy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Plus-stranded (+)RNA viruses infect all kind of species and cause many serious diseases in humans, animals and plants, leading to major losses in food production and representing significant risk to ..
  58. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2013
    ..in response to double stranded (ds) DNA viruses, herpes simplex viruses (HSV), and single stranded (ss) RNA viruses, influenza and vesicular stomatitis virus (VSV), respectively...
  59. mRNA synthesis and capping in nonsegmented negative strand RNA viruses
    Tomoaki Ogino; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nonsegmented negative strand (NNS) RNA viruses include many life-threatening human pathogens, such as rabies, measles, and Ebola. However, there is presently no effective drug against NNS RNA viruses...
  60. Molecular Basis of Paramyxovirus-Induced STAT Degradation
    Curt M Horvath; Fiscal Year: 2012
    ..The Paramyxovirus family of negative-strand RNA viruses includes a number of well known and emerging human pathogens with significant health consequences...
  61. Enterovirus infection of polarized intestinal cells
    Carolyn B Coyne; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxsackievirus B (CVB), a member of the enterovirus family of RNA viruses, is associated with a number of diverse syndromes, including meningitis, pericarditis, febrile illness, diabetes, dilated ..
  62. Hantavirus RNA Encapsidation and Packaging
    Antonito T Panganiban; Fiscal Year: 2012
    ..of the hantavirus genus the entire Bunyaviridae family, and other medically important segmented minus strand RNA viruses such as influenza...
  63. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
    The host plays a role not only in replication of plus-stranded RNA viruses, but also in viral RNA recombination, although the role(s) of host factors in recombination is currently unknown...
  64. CONTROL OF CELL FUNCTION VIA SELECTIVE MRNA TRANSLATION
    Lee Gehrke; Fiscal Year: 2002
    ..The model system used in this project is a group of positive-sense single-stranded RNA viruses, alfalfa mosaic virus and ilarviruses, which are closely related to human alphaviruses that cause severe ..
  65. Role of an essential RNA chaperone in virus replication
    Peter Nagy; Fiscal Year: 2006
    RNA replication is the central step in the infection cycles of plus-strand RNA viruses, which cause many diseases in humans, animals and plants...
  66. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    Poliovirus is a member of the Picornaviridae family of small positive-strand RNA viruses. Diseases associated with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold...
  67. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): RNA viruses are a significant cause of morbidity and mortality in humans...
  68. Regulation of Sindbis Virus Subgenomic RNA Synthesis
    Victor Stollar; Fiscal Year: 2010
    Sindbis virus, (SV) one of the simplest, enveloped RNA viruses, is the prototype virus of the family Togaviridae, genus alphavirus. It is transmitted to its vertebrate hosts by mosquitoes...
  69. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
    ..provided by applicant): The arsenal of antiviral agents that may be useful for treatment of infections by RNA viruses classified as either category A, B or C pathogens consists of one compound, ribavirin...
  70. RNA REPAIR AND RECOMBINATION--AN ALPHAVIRUS MODEL
    RAMASAMY RAJU; Fiscal Year: 2001
    ..Despite the increased vulnerability of RNA for nucleolytic breakdown, RNA viruses continue to overpopulate the virus world...
  71. EFFECTORS AND IINHIBITORS OF SARS VIRUS POLYMERASE
    Neerja Kaushik Basu; Fiscal Year: 2006
    Replication of positive stranded RNA viruses in virus-infected cells is believed to be catalyzed by viral replicase complexes, which may consist of various virally encoded nonstructural proteins including the RNA dependent RNA ..
  72. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2009
    ..The priority pathogens include a group of highly contagious RNA viruses that cause widespread illness and death in exposed population centers...
  73. Role of Cellular P-bodies and Hantavirus Nucleocapsid Protein in Viral mRNA "cap
    MOHAMMAD AYOUB MIR; Fiscal Year: 2010
    ..This general cap snatching mechanism has been assumed for all minus stranded segmented RNA viruses including the bunyaviruses and arenaviruses, although their RdRps are structurally different and they replicate ..