parvovirus

Summary

Summary: A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MICE MINUTE VIRUS.

Top Publications

  1. pmc Cloning of a human parvovirus by molecular screening of respiratory tract samples
    Tobias Allander
    Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:12891-6. 2005
  2. pmc Human parvovirus 4 as potential cause of encephalitis in children, India
    Laura A Benjamin
    University of Liverpool Institute of Infection and Global Health, Liverpool, UK
    Emerg Infect Dis 17:1484-7. 2011
  3. pmc Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus
    Andrew B Allison
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    J Virol 86:865-72. 2012
  4. pmc Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus
    Herman Tse
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e25619. 2011
  5. pmc High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in shanghai
    Xuelian Yu
    Microbiology Laboratory, Shanghai Municipal Center for Disease Prevention and Control, Shanghai, People s Republic of China
    PLoS ONE 7:e29474. 2012
  6. ncbi Naturally occurring parvoviral infection in Hungarian broiler flocks
    Elena Alina Palade
    Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science, Szent Istvan University, Budapest, Istvan utca 2, Hungary
    Avian Pathol 40:191-7. 2011
  7. ncbi Improvement of gemcitabine-based therapy of pancreatic carcinoma by means of oncolytic parvovirus H-1PV
    Assia L Angelova
    Infection and Cancer Programme F010 and INSERM U701, German Cancer Research Center, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Clin Cancer Res 15:511-9. 2009
  8. pmc Serodiagnosis of primary infections with human parvovirus 4, Finland
    Anne Lahtinen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Emerg Infect Dis 17:79-82. 2011
  9. ncbi Parvovirus 4 in French in-patients: a study of hemodialysis and lung transplant cohorts
    Mhammed Touinssi
    Viral Emergence and Co evolution Unit, French Blood Agency Alpes Mediterranee and University of Mediterranee, Marseille, France
    J Med Virol 83:717-20. 2011
  10. pmc Changing epidemiology of human parvovirus 4 infection in sub-Saharan Africa
    Colin P Sharp
    University of Edinburgh, Edinburgh, Scotland, UK
    Emerg Infect Dis 16:1605-7. 2010

Research Grants

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  2. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  3. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
  4. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
  5. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
  6. The Evolutionary and Biological Bases of Host Switching in Viruses
    Colin R Parrish; Fiscal Year: 2013
  7. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
  8. Glioma immunotherapy with strategies based on autonomous parvovirus MVMp
    JUSTIN COBB PAGLINO; Fiscal Year: 2013
  9. Screens for host DNA replication and repair factors involved in viral infection
    Matthew D Weitzman; Fiscal Year: 2010
  10. LuIII parvovirus targets glioma
    Anthony N van den Pol; Fiscal Year: 2013

Detail Information

Publications257 found, 100 shown here

  1. pmc Cloning of a human parvovirus by molecular screening of respiratory tract samples
    Tobias Allander
    Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:12891-6. 2005
    ..Among the detected viruses were one coronavirus and one parvovirus, both of which were at that time uncharacterized...
  2. pmc Human parvovirus 4 as potential cause of encephalitis in children, India
    Laura A Benjamin
    University of Liverpool Institute of Infection and Global Health, Liverpool, UK
    Emerg Infect Dis 17:1484-7. 2011
    ..A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.
  3. pmc Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus
    Andrew B Allison
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    J Virol 86:865-72. 2012
    ..Canine parvovirus type 2 (CPV-2) emerged as a variant of a feline parvovirus when it acquired mutations that allowed binding to ..
  4. pmc Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus
    Herman Tse
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e25619. 2011
    ..which include the human partetravirus, bovine partetravirus and porcine partetravirus (previously known as human parvovirus 4, bovine hokovirus and porcine hokovirus respectively)...
  5. pmc High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in shanghai
    Xuelian Yu
    Microbiology Laboratory, Shanghai Municipal Center for Disease Prevention and Control, Shanghai, People s Republic of China
    PLoS ONE 7:e29474. 2012
    Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users...
  6. ncbi Naturally occurring parvoviral infection in Hungarian broiler flocks
    Elena Alina Palade
    Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science, Szent Istvan University, Budapest, Istvan utca 2, Hungary
    Avian Pathol 40:191-7. 2011
    ..The objective of the present study was to directly demonstrate the presence of the scarcely known chicken parvovirus (ChPV) and turkey parvovirus (TuPV) in Hungarian flocks experiencing clinical signs of ED...
  7. ncbi Improvement of gemcitabine-based therapy of pancreatic carcinoma by means of oncolytic parvovirus H-1PV
    Assia L Angelova
    Infection and Cancer Programme F010 and INSERM U701, German Cancer Research Center, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Clin Cancer Res 15:511-9. 2009
    ..Complementary treatment with an oncolytic virus, such as the rat parvovirus H-1PV, which is infectious but nonpathogenic in humans, emerges as an innovative option.
  8. pmc Serodiagnosis of primary infections with human parvovirus 4, Finland
    Anne Lahtinen
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Emerg Infect Dis 17:79-82. 2011
    To determine the prevalence of parvovirus 4 infection and its clinical and sociodemographic correlations in Finland, we used virus-like particle-based serodiagnostic procedures (immunoglobulin [Ig] G, IgM, and IgG avidity) and PCR...
  9. ncbi Parvovirus 4 in French in-patients: a study of hemodialysis and lung transplant cohorts
    Mhammed Touinssi
    Viral Emergence and Co evolution Unit, French Blood Agency Alpes Mediterranee and University of Mediterranee, Marseille, France
    J Med Virol 83:717-20. 2011
    The epidemiology and the clinical implication of human parvovirus 4 (PARV4) in human populations is still under evaluation. The distribution of PARV4 DNA was determined in cohorts of French hemodialysis and lung transplant patients...
  10. pmc Changing epidemiology of human parvovirus 4 infection in sub-Saharan Africa
    Colin P Sharp
    University of Edinburgh, Edinburgh, Scotland, UK
    Emerg Infect Dis 16:1605-7. 2010
    Human parvovirus 4 infections are primarily associated with parenteral exposure in western countries...
  11. ncbi Parvovirus H-1-induced tumor cell death enhances human immune response in vitro via increased phagocytosis, maturation, and cross-presentation by dendritic cells
    Markus H Moehler
    Department of Medicine I, Johannes Gutenberg University Mainz, Germany
    Hum Gene Ther 16:996-1005. 2005
    ..Because wild-type parvovirus-mediated tumor cell lysates (TCLs) may trigger antigen-presenting cells (APCs) to augment the host immune ..
  12. pmc A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species
    T Allander
    Sections for Hepatitis Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:11609-14. 2001
    ..DNase treatment of serum samples may prove to be a very useful tool for virus discovery. The DNase-SISPA method is suitable for screening of a large number of samples and also enables rapid sequence determination of high-titer viruses...
  13. pmc Comparative analysis reveals frequent recombination in the parvoviruses
    Laura A Shackelton
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    J Gen Virol 88:3294-301. 2007
    ..Further, the rodent parvoviruses show complex evolutionary histories for separate genomic regions, suggesting recombination at the interspecies level...
  14. ncbi Parvovirus infections in wild carnivores
    A Steinel
    Institute for Medical Microbiology, Infectious and Epidemic Diseases, University of Munich, Germany
    J Wildl Dis 37:594-607. 2001
    ..of free-ranging or captive carnivores with the feline parvoviruses, feline panleukopenia virus, and canine parvovirus, including the antigenic types CPV-2a and -2b, as well as Aleutian disease of mink virus and minute virus of ..
  15. ncbi Oncolytic parvoviruses as cancer therapeutics
    Jean Rommelaere
    Division of Tumor Virology, German Cancer Research Center, and Cancer Virotherapy Unit, French National Institute of Health and Medical Research, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Cytokine Growth Factor Rev 21:185-95. 2010
    ..In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist ..
  16. ncbi Molecular detection of Muscovy duck parvovirus by loop-mediated isothermal amplification assay
    J Ji
    College of Animal Science, South China Agricultural University, Guangzhou 510642, People s Republic of China
    Poult Sci 89:477-83. 2010
    Muscovy duck parvovirus (MDPV) usually causes high morbidity and mortality in 1- to 3-wk-old Muscovy ducklings due to serious infections, which is an imminent threat to the commercial duck industry in China...
  17. pmc High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
    Ruth Simmons
    Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
    J Infect Dis 203:1378-87. 2011
    b>Parvovirus 4 (PARV4) is a recently identified human virus that has been found in livers of patients infected with hepatitis C virus (HCV) and in bone marrow of individuals infected with human immunodeficiency virus (HIV)...
  18. pmc Two novel parvoviruses in frugivorous New and Old World bats
    Marta Canuti
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity CINIMA, Academic Medical Centre AMC, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e29140. 2011
    ..We also provide evidence that a variety of Parvovirinae are able to cause active infection in bats and that they are widely distributed in these animals with different geographic origin, ecologies and climatic ranges...
  19. ncbi Identification and phylogenetic diversity of parvovirus circulating in commercial chicken and turkey flocks in Croatia
    M Bidin
    Department of Poultry Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
    Avian Dis 55:693-6. 2011
    Phylogenetic diversity of parvovirus detected in commercial chicken and turkey flocks is described. Nine chicken and six turkey flocks from Croatian farms were tested for parvovirus presence...
  20. ncbi Contact rates between wild and domestic canids: no evidence of parvovirus or canine distemper virus in crab-eating foxes
    O Courtenay
    Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK
    Vet Microbiol 81:9-19. 2001
    ..Foxes and dogs were serologically and clinically monitored for exposure to canine parvovirus (CPV-2) and canine distemper virus (CDV), pathogens known to have caused wildlife population declines elsewhere...
  21. pmc Oncolytic rat parvovirus H-1PV, a candidate for the treatment of human lymphoma: In vitro and in vivo studies
    Assia L Angelova
    Institut National de la Sante et de la Recherche Medicale, German Cancer Research Center, Heidelberg, Germany
    Mol Ther 17:1164-72. 2009
    ..Autonomous parvoviruses (PVs), in particular the rat parvovirus H-1PV, have emerged as promising anticancer agents...
  22. ncbi Parvovirus PARV4 visualization and detection
    Philip W Tuke
    Health Protection Agency, Centre for Infections, Virus Reference Department, 61 Colindale Avenue, London NW9 5HT, UK
    J Gen Virol 91:541-4. 2010
    The parvovirus PARV4 is the most recently described member of the family Parvoviridae that has a human host...
  23. pmc The transcription profile of the bocavirus bovine parvovirus is unlike those of previously characterized parvoviruses
    Jianming Qiu
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 81:12080-5. 2007
    The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenylation and splicing was different from that of other parvoviruses...
  24. ncbi Cell death in bovine parvovirus-infected embryonic bovine tracheal cells is mediated by necrosis rather than apoptosis
    Lubna Abdel-Latif
    Department of Microbiology and Molecular Biology, Brigham Young University, 887 WIDB, Provo, UT 84602, USA
    J Gen Virol 87:2539-48. 2006
    The helper-independent bovine parvovirus (BPV) was studied to determine its effect on host embryonic bovine tracheal (EBTr) cells: whether the ultimate outcome of infection results in apoptotic cell death or cell death by necrosis...
  25. pmc Parvoviruses in blood donors and transplant patients, Italy
    Daniela Vallerini
    Emerg Infect Dis 14:185-6. 2008
  26. ncbi Analysis of the complete nucleotide sequences of goose and muscovy duck parvoviruses indicates common ancestral origin with adeno-associated virus 2
    Z Zadori
    Research Department, Phylaxia Sanofi Veterinary Biologicals Co LTD, Budapest, Hungary
    Virology 212:562-73. 1995
    ..This is surprising, because the goose and muscovy duck parvoviruses do not require any helper virus for productive replication, suggesting that adeno-associated virus 2 has been derived from a helper-independent ancestor...
  27. pmc High frequencies of exposure to the novel human parvovirus PARV4 in hemophiliacs and injection drug users, as detected by a serological assay for PARV4 antibodies
    Colin P Sharp
    Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 200:1119-25. 2009
    PARV4 is a human parvovirus that was first detected in and cloned from an individual with a human immunodeficiency virus (HIV) seroconversion-like illness and that subsequently persisted in the lymphoid tissue and bone marrow...
  28. ncbi Determination and analysis of the full-length chicken parvovirus genome
    J Michael Day
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA
    Virology 399:59-64. 2010
    ..nucleic acid (PAN), we recently described the detection and partial characterization of a novel enteric parvovirus in chickens...
  29. ncbi Immunoglobulin G and M antibodies to human parvovirus 4 (PARV4) are frequently detected in patients with HIV-1 infection
    Shiu Ju Yang
    Department of Internal Medicine, National Taiwan University Hospital, No 7, Chung Shan South Road, 100 Taipei, Taiwan
    J Clin Virol 51:64-7. 2011
    ..The transmission routes of PARV4 are not completely understood. The first PARV4 serological study suggested that PARV4 is transmitted predominantly through parenteral route...
  30. ncbi Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK
    J Gen Virol 82:3011-9. 2001
    To investigate whether cytokine responses may have a bearing on the symptoms and outcome of parvovirus B19 infection, circulating cytokines were measured during acute infection (n=51), follow-up of acute infection (n=39) and in normal ..
  31. ncbi Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors
    M Moehler
    Department of Internal Medicine, University of Mainz, Germany
    Cancer Gene Ther 8:158-67. 2001
    ..Here, we assessed whether parvovirus H1 is able to kill human hepatoma cells by induction of apoptosis but spares primary human liver cells, and ..
  32. ncbi The parvovirus capsid odyssey: from the cell surface to the nucleus
    Carole E Harbison
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Trends Microbiol 16:208-14. 2008
    During cellular entry and infection, the parvovirus capsid follows a complex path from the cell surface to the nucleus, where the DNA is replicated...
  33. ncbi The canine minute virus (minute virus of canines) is a distinct parvovirus that is most similar to bovine parvovirus
    Daniel Schwartz
    James A Baker Institute and Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 302:219-23. 2002
    ..The genome sequence showed MVC to be an autonomous parvovirus encoding a large nonstructural protein 1 gene, a smaller nonstructural protein, and overlapping VP1 and VP2 ..
  34. pmc Parvovirus 4-like virus in blood products
    Jozsef Szelei
    Institut National de la Recherche Scientifique Institut Armand Frappier, Laval, Quebec, Canada
    Emerg Infect Dis 16:561-4. 2010
    Porcine plasma and factor VIII preparations were screened for parvovirus 4 (PARV)-like viruses...
  35. pmc Parvovirus induced alterations in nuclear architecture and dynamics
    Teemu O Ihalainen
    Nanoscience Center, Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    PLoS ONE 4:e5948. 2009
    ..microscopy and computational methods to analyze the modifications of nuclear architecture and dynamics in parvovirus infected cells...
  36. ncbi Human parvovirus PARV4 in plasma pools of Chinese origin
    Y Y Ma
    Laboratory for Viral Safety of National Centre of Biomedical Analysis, Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
    Vox Sang 103:183-5. 2012
    Human parvovirus 4 (PARV4) is present in blood and blood products...
  37. ncbi Expression of muscovy duck parvovirus capsid proteins (VP2 and VP3) in a baculovirus expression system and demonstration of immunity induced by the recombinant proteins
    G Le Gall-Reculé
    Unité de Pathologie Aviaire, CNEVA, Laboratoire Central de Recherches Avicole et Porcine, Ploufragan, France
    J Gen Virol 77:2159-63. 1996
    The gene encoding the muscovy duck parvovirus (DPV)-strain 89384 capsid proteins VP2 and VP3 was cloned in a baculovirus expression system and expressed in insect cells...
  38. pmc Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus
    Tung G Phan
    Blood Systems Research Institute, San Francisco, California, USA
    J Virol 86:11024-30. 2012
    ..Sequences from a highly divergent parvovirus, provisionally called bufavirus, were also detected whose NS1 and VP1 proteins showed <39% and <31% ..
  39. ncbi Parvovirus transmission by blood products - a cause for concern?
    Päivi Norja
    Department of Virology, Haartman Institute, Helsinki University, Helsinki, Finland
    Br J Haematol 159:385-93. 2012
    ..have remained, as it is known that currently available viral inactivation methods are unable to eliminate parvovirus B19 or prions from these products...
  40. ncbi Epizootiologic investigations of parvovirus infections in free-ranging carnivores from Germany
    Kai Frölich
    Institute for Zoo and Wildlife Research Berlin, Alfred Kowalke Str 17, PO Box 601103, 10252 Berlin, Germany
    J Wildl Dis 41:231-5. 2005
    To assess if wild carnivores in Germany play a role in the epizootiology of canine parvovirus (CPV) infection, seroprevalences against CPV in free-ranging carnivores (n=1,496) from selected urban and rural areas were compared...
  41. pmc Novel human parvovirus 4 genotype 3 in infants, Ghana
    Marcus Panning
    Institute of Virology, University of Bonn Medical Centre, Sigmund Freud Str 25 53127 Bonn, Germany
    Emerg Infect Dis 16:1143-6. 2010
    Human parvovirus 4 has been considered to be transmitted only parenterally. However, after novel genotype 3 of parvovirus 4 was found in 2 patients with no parenteral risks, we tested infants in Ghana. A viremia rate of 8...
  42. ncbi The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells in vitro and in vivo
    Muhannad Alkassar
    Department for Pediatric Oncology, University of Saarland Medical School, 66424, Homburg, Saar, Germany
    J Neurooncol 104:715-27. 2011
    Previous results had documented oncolytic capacity of reovirus, parvovirus and Newcastle disease virus (NDV) on several tumor cell types...
  43. ncbi Parvovirus-associated cerebellar hypoplasia and hydrocephalus in day old broiler chickens
    R A Marusak
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Avian Dis 54:156-60. 2010
    ..b>Parvovirus DNA was detected by polymerase chain reaction in three of nine brains with oligonucleotide primers designed for ..
  44. ncbi Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals
    Jacqueline F Fryer
    Division of Virology, National Institute for Biological Standards and Control, Hertfordshire, United Kingdom
    Transfusion 47:1054-61. 2007
    ..pools used in the manufacture of blood- and plasma-derived medicinal products are frequently contaminated with parvovirus B19...
  45. pmc Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading
    Jürg P F Nüesch
    Program Infection and Cancer, Abt F010 and INSERM U701, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Virol 83:5854-63. 2009
    ..Conversely, radixin phosphorylation and activation were driven by the NS1/CKIIalpha complex. Altogether, these data argue for ERM proteins being both targets and modulators of parvovirus infection.
  46. ncbi Partial genome sequence analysis of parvoviruses associated with enteric disease in poultry
    L Zsak
    Southeast Poultry Research Laboratory, USDA ARS, Athens, GA 30605, USA
    Avian Pathol 37:435-41. 2008
    ..Using this method we successfully identified parvovirus DNA sequences in intestinal homogenates of affected birds...
  47. pmc Natural co-infection with 2 parvovirus variants in dog
    Maria João Vieira
    Emerg Infect Dis 14:678-9. 2008
  48. pmc Parenteral transmission of the novel human parvovirus PARV4
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, Scotland, United Kingdom
    Emerg Infect Dis 13:1386-8. 2007
    Transmission routes of PARV4, a newly discovered human parvovirus, were investigated by determining frequencies of persistent infections using autopsy samples from different risk groups...
  49. pmc A canine parvovirus mutant is spreading in Italy
    Vito Martella
    Department of Animal Health and Wellbeing, University of Bari, Bari, Italy
    J Clin Microbiol 42:1333-6. 2004
    By antigenic and genetic characterization of canine parvovirus type 2 (CPV-2) strains collected in 2001 and 2002 in Italy, it was possible to observe the spread of viruses with an unusual mutation, Glu-426, affecting a major antigenic ..
  50. pmc Human parvovirus 4 infection, Cameroon
    Myriam Lavoie
    Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Emerg Infect Dis 18:680-3. 2012
    In a post hoc analysis of samples collected in 2009, we determined seroprevalence of parvovirus 4 (PARV4) among elderly Cameroonians...
  51. ncbi Epidemiologic investigation of an outbreak of goose parvovirus infection in Sweden
    Desiree S Jansson
    National Veterinary Institute, Department of Pigs, Poultry and Ruminants, SE 75189 Uppsala, Sweden
    Avian Dis 51:609-13. 2007
    An outbreak of goose parvovirus (GPV) infection on a Swedish goose farm in the spring of 2004 increased the mortality rates from 2% in the early unaffected hatches to 90% and 99% respectively in the two hatches following virus ..
  52. ncbi Frequency of contamination of coagulation factor concentrates with novel human parvovirus PARV4
    B Schneider
    Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
    Haemophilia 14:978-86. 2008
    Human parvovirus, PARV4 was identified in a plasma sample from a patient presenting with symptoms resembling acute HIV infection...
  53. ncbi Detection of PARV4, genotypes 1 and 2, in healthy and pathological clinical specimens
    Sara Botto
    Department of Public Health and Microbiology, Virology Unit, Turin University, Italy
    New Microbiol 32:189-92. 2009
    The molecular epidemiology and tissue distribution of Human Parvovirus 4 (PARV4) and its variant PARV5 (Parvoviridae family) are poorly known...
  54. ncbi Parvovirus B19: implications for transfusion medicine. Summary of a workshop
    K E Brown
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Transfusion 41:130-5. 2001
    ..If clinical trials were to be developed, participants recommended that they include special risk groups such as seronegative pregnant women and children with malignancies who are receiving chemotherapy...
  55. pmc Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence
    Alberto López-Bueno
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    J Virol 80:1563-73. 2006
    ..in the infection of severe combined immunodeficient (SCID) mice by the apathogenic prototype strain of the parvovirus minute virus of mice (MVMp)...
  56. ncbi High prevalence of turkey parvovirus in turkey flocks from Hungary experiencing enteric disease syndromes
    Elena Alina Palade
    Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science, Szent Istvan University, 1078 Budapest, Istvan utca 2, Hungary
    Avian Dis 55:468-75. 2011
    ..associated with enteric disease (ED) syndromes: astrovirus, reovirus, rotavirus, coronavirus, adenovirus, and parvovirus. Turkey astroviruses were found in 83.67% of the cases and turkey astrovirus 2 (TAst-2) in 26.53%...
  57. pmc Placental transmission of human parvovirus 4 in newborns with hydrops, Taiwan
    Mao Yuan Chen
    National Taiwan University Hospital, Taipei, Taiwan
    Emerg Infect Dis 17:1954-6. 2011
    In studying the epidemiology of parvovirus 4 (PARV4) in Taiwan, we detected DNA in plasma of 3 mothers and their newborns with hydrops. In 1 additional case, only the mother had PARV4 DNA...
  58. pmc Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication
    Richard O Adeyemi
    University of Missouri Columbia, School of Medicine, Columbia, Missouri, United States of America
    PLoS Pathog 6:e1001141. 2010
    ..We find that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DDR, characterized by the phosphorylation of H2AX, ..
  59. ncbi Cellular transcription factors that interact with p6 promoter elements of parvovirus B19
    U Raab
    , , Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany
    J Gen Virol 82:1473-80. 2001
    All transcripts of the human parvovirus B19 identified so far are regulated by a single promoter at map unit 6 of the viral genome, the so-called p6 promoter. This promoter is active in a wide variety of different cells...
  60. ncbi Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells
    Markus Moehler
    Department of Internal Medicine, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Cancer Gene Ther 10:477-80. 2003
    ..We asked whether the lytic parvovirus H1 may enhance the immunogenicity of infected tumor cells...
  61. ncbi Cancer gene therapy through autonomous parvovirus--mediated gene transfer
    Jan J Cornelis
    Deutsches Krebsforschungszentrum, Abteilung F010 and Institut National de la Santé et de la Recherche Médicale, Unité 375, Postfach 101949, D 69009 Heidelberg, Germany
    Curr Gene Ther 4:249-61. 2004
    ..malignant transformation of human and rodent cells was often found to correlate with a greater susceptibility to parvovirus-induced killing (oncolysis) and with an increase in the cellular capacity for amplifying and / or expressing the ..
  62. ncbi Parvovirus-like particles as vaccine vectors
    J I Casal
    INGENASA, Hnos Garcia Noblejas 41, 4 degrees, Madrid, 28037, Spain
    Methods 19:174-86. 1999
    ..We used parvovirus as the model for the design of new vaccine vectors...
  63. ncbi Genomic organization and mapping of transcription and translation products of the NADL-2 strain of porcine parvovirus
    J Bergeron
    Centre de Recherche en Virologie, Institut Armand Frappier, Universite du Quebec, Laval, Canada
    Virology 197:86-98. 1993
    ..A flow chart of the information from the viral DNA to the viral proteins is presented and several differences, both for the NS and the VP genes, with closely related parvoviruses are noted...
  64. ncbi Human parvovirus PARV4 in clotting factor VIII concentrates
    J F Fryer
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Vox Sang 93:341-7. 2007
    ..The recently identified human parvovirus PARV4, including a related genotype 2 virus (also termed PARV5), has been found to be a contaminant of pooled ..
  65. pmc Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 75:2729-40. 2001
    ..The two lineages of human parvoviruses may have resulted from independent ancient zoonotic infections. Our results provide an argument for reclassification of Parvovirinae based on evolutionary relationships among viruses...
  66. ncbi A third genotype of the human parvovirus PARV4 in sub-Saharan Africa
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Gen Virol 89:2299-302. 2008
    PARV4 is a recently discovered human parvovirus widely distributed in injecting drug users in the USA and Europe, particularly in those co-infected with human immunodeficiency virus (HIV)...
  67. ncbi Identification of novel murine parvovirus strains by epidemiological analysis of naturally infected mice
    David G Besselsen
    University Animal Care, University of Arizona, Tucson, AZ, USA
    J Gen Virol 87:1543-56. 2006
    ..infected laboratory mice (n=381) were evaluated by PCR and RFLP analysis to determine the prevalence of murine parvovirus strains circulating in contemporary laboratory mouse colonies...
  68. ncbi The effect of porcine parvovirus and porcine reproductive and respiratory syndrome virus on porcine reproductive performance
    W L Mengeling
    Virology Swine Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    Anim Reprod Sci 60:199-210. 2000
    From a worldwide perspective, porcine parvovirus (PPV) and porcine reproductive and respiratory syndrome virus (PRRSV) are the most common viral causes of porcine reproductive failure...
  69. ncbi Parvovirus host range, cell tropism and evolution
    Karsten Hueffer
    JA Baker Institute for Animal Health, Department of Microbiology Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Curr Opin Microbiol 6:392-8. 2003
    ..have included the identification of the transferrin receptor TfR as the cell surface receptor for canine parvovirus and feline panleukopenia virus, and also the finding that specific binding to the canine TfR led to the ..
  70. ncbi In vitro disassembly of a parvovirus capsid and effect on capsid stability of heterologous peptide insertions in surface loops
    Aura Carreira
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 279:6517-25. 2004
    ..The results with one of the simplest viral capsids reveal a complex pathway for disassembly, and a reduction in capsid assembly and stability upon insertion of peptides, even within the most exposed capsid loops...
  71. ncbi Canine parvovirus enteritis, canine distemper, and major histocompatibility complex genetic variation in Mexican wolves
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    J Wildl Dis 39:909-13. 2003
    ..In 1999 and 2000, pups from three litters that were part of the reintroduction program died of either canine parvovirus or canine distemper...
  72. pmc Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway
    B Rayet
    Angewandte Tumorvirologie, Abteilung F0100, Deutsches Krebsforschungszentrum, and Virologie Appliquée à l Oncologie Unité INSERM 375, D 69009 Heidelberg, Germany
    J Virol 72:8893-903. 1998
    ..This cell line has previously been shown to be very sensitive to the lytic effect of the autonomous parvovirus H-1...
  73. ncbi Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvovirus B
    Jonathan R Kerr
    Department of Paediatric Infectious Diseases, St Mary s Campus, Imperial College, London, United Kingdom
    J Infect Dis 192:276-86. 2005
    This study was undertaken to further examine the role of the host response to parvovirus B19 in the development of symptoms and consequences of viral persistence...
  74. pmc Evidence of parvovirus replication in cerebral neurons of cats
    Angelika Url
    Institute of Pathology and Forensic Veterinary Medicine, Veterinary University of Vienna, A 1210 Vienna, Austria
    J Clin Microbiol 41:3801-5. 2003
    The correlation between parvovirus infections and lesions in the central nervous system other than cerebellar hypoplasia was studied in 100 cats...
  75. ncbi First evidence of feline herpesvirus, calicivirus, parvovirus, and Ehrlichia exposure in Brazilian free-ranging felids
    Claudia Filoni
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sã o Paulo, Avenida Prof Dr Orlando Marques de Paiva 87, 05508 270, Sao Paulo, SP, Brazil
    J Wildl Dis 42:470-7. 2006
    ..Antibodies to FHV 1, FCV, FCoV, FPV, FeLV, FIV, PLV or related viruses, and to B. henselae were detected. Furthermore, high-titered antibodies to E. canis or a closely related agent were detected in a puma for the first time...
  76. pmc Widespread infection with homologues of human parvoviruses B19, PARV4, and human bocavirus of chimpanzees and gorillas in the wild
    Colin P Sharp
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Virol 84:10289-96. 2010
    ..This study provides the first evidence for widespread circulation of parvoviruses in primates and enables future investigations of their epidemiology, host specificity, and (co)evolutionary histories...
  77. pmc Resolution of parvovirus dimer junctions proceeds through a novel heterocruciform intermediate
    Susan F Cotmore
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Virol 77:6245-54. 2003
    ..We suggest that the latter intermediate is finally resolved via an NS1-induced single-strand nick at the otherwise inactive origin, OriL(GAA)...
  78. ncbi Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR
    S Cao
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China
    Vet Res Commun 29:263-9. 2005
    Multiplex PCR was established to detect porcine circovirus type 2 (PCV-2), porcine parvovirus (PPV) and porcine pseudorabies virus (PRV) and applied to samples from 137 piglets exhibiting clinical signs of postweaning multisystemic ..
  79. ncbi Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus
    S Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, USA
    Vet Pathol 37:254-63. 2000
    ..piglets were inoculated intranasally with in vitro passaged porcine circovirus 1 (PCV-1), PCV-2, and porcine parvovirus (PPV) alone or in combination (PCV-1/PCV-2, PCV-1/PPV, and PCV-2/PPV)...
  80. ncbi Parvovirus variation for disease: a difference with RNA viruses?
    A López-Bueno
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    Curr Top Microbiol Immunol 299:349-70. 2006
    ..b>Parvovirus populations show high genetic heterogeneity and large population sizes resembling the quasispecies found in RNA ..
  81. ncbi Analysis of two human parvovirus PARV4 genotypes identified in human plasma for fractionation
    Jacqueline F Fryer
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK
    J Gen Virol 88:2162-7. 2007
    The presence of the novel parvovirus PARV4 and a related variant, PARV5, was recently demonstrated in pooled plasma used in the manufacture of blood and plasma-derived medicinal products...
  82. ncbi Interfacial enzymology of parvovirus phospholipases A2
    Stephane Canaan
    Departments of Chemistry and Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:14502-8. 2004
    ..The specific activities of three viral PLA(2)s differed by 3 orders of magnitude, with porcine parvovirus PLA(2) displaying a specific activity similar to that of the most active sPLA(2)s (e.g...
  83. ncbi Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administration Region, Hong Kong SAR
    J Gen Virol 89:1840-8. 2008
    Human parvovirus 4 (PARV4), a recently discovered parvovirus found exclusively in human plasma and liver tissue, was considered phylogenetically distinct from other parvoviruses...
  84. ncbi A viral phospholipase A2 is required for parvovirus infectivity
    Z Zadori
    Centre de Microbiologie et Biotechnologie, INRS Institut Armand Frappier Université du Quebec, Laval, Canada
    Dev Cell 1:291-302. 2001
    ..PLA2 activity is not known to exist in viruses, putative PLA2s from divergent parvoviruses, human B19, porcine parvovirus, and insect GmDNV (densovirus from Galleria mellonella), can emulate catalytic properties of secreted PLA2...
  85. ncbi A recombinant virus-like particle system derived from parvovirus as an efficient antigen carrier to elicit a polarized Th1 immune response without adjuvant
    R Lo-Man
    Unité de Biologie des Régulations Immunitaires, Institut Pasteur, Paris, France
    Eur J Immunol 28:1401-7. 1998
    Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope...
  86. ncbi Parvovirus H-1 infection of human glioma cells leads to complete viral replication and efficient cell killing
    Marta Herrero Y Calle
    Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 109:76-84. 2004
    ..e., the application of oncolytic viruses. In our study, we evaluated the effects of the oncosuppressive parvovirus H-1 on different established glioblastoma cell lines of rat and human origin and on short-term/low-passage ..
  87. ncbi Complete nucleotide sequence and genomic organization of the Aedes albopictus parvovirus (AaPV) pathogenic for Aedes aegypti larvae
    Y Boublik
    Unite de Virologie Moleculaire, INRA UA CNRS 1184, Saint Christol lez Alès, France
    Virology 200:752-63. 1994
    We have cloned the replicative form of the Aedes albopictus parvovirus (AaPV) genome and determined the complete sequence of the viral strand. The sequence is 4176 nucleotides (nt) in length...
  88. ncbi Novel parvovirus sublineage in the family of Parvoviridae
    Fang Wang
    Key Lab of Animal Epidemic Etiology and Immunological Prevention of MOA, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Virus Genes 41:305-8. 2010
    ..Based on these results, we propose a novel parvovirus sublineage, Cnvirus, to describe these parvoviruses.
  89. ncbi Inactivation of parvovirus B19 in coagulation factor concentrates by UVC radiation: assessment by an in vitro infectivity assay using CFU-E derived from peripheral blood CD34+ cells
    H Sugawara
    Hokkaido Red Cross Blood Center, Nishi-ku, Japan
    Transfusion 41:456-61. 2001
    BACKGROUND: Nonenveloped and thermostable viruses such as parvovirus B19 (B19) can be transmitted to patients who are receiving plasma-derived coagulation factor concentrates treated by the S/D method for inactivating enveloped viruses...
  90. ncbi VP2 gene of a canine parvovirus isolate from stool of a puppy
    Kentarou Hirayama
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kameino, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 67:139-43. 2005
    VP2 gene of a canine parvovirus (CPV) isolate from the feces of a puppy which was diagnosed to be CPV infection was analysed...
  91. ncbi Increasing the capacity of parvovirus-retentive membranes: performance of the Viresolve Prefilter
    Glen R Bolton
    Millipore Corporation, 32 Wiggins L2B, Bedford, MA 01730, USA
    Biotechnol Appl Biochem 43:55-63. 2006
    ..were investigated for their ability to remove the species that foul Viresolvetrade mark NFP (normal-flow parvovirus) filters...
  92. ncbi Interactions of viruses with the cellular DNA repair machinery
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    DNA Repair (Amst) 3:1165-73. 2004
    ..Exploring the interactions between viruses and the host DNA repair machinery has revealed novel host responses to virus infections and has provided new tools to study the DNA damage response...
  93. pmc Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses
    C Sedlik
    Unité de Biologie des Régulations Immunitaires, 75724 Paris Cedex 15, France, and Ingenasa, 28037 Madrid, Spain
    J Virol 73:2739-44. 1999
    We previously demonstrated that chimeric porcine parvovirus-like particles (PPV:VLP) carrying heterologous epitopes, when injected intraperitoneally into mice without adjuvant, activate strong CD4(+) and CD8(+) T-cell responses specific ..
  94. pmc Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)d and subsequent appearance of a resistant cell clone after lytic infection
    Y Ueno
    Institute of Basic Medical Sciences and Laboratory Animal Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
    J Virol 75:3965-70. 2001
    Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis...
  95. ncbi Isolation and identification of goose parvovirus in the UK
    Dick Gough
    Vet Rec 156:424. 2005
  96. ncbi Report of a collaborative study to calibrate the Second International Standard for parvovirus B19 antibody
    Morag Ferguson
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3 QG, UK
    Biologicals 32:207-12. 2004
    ..study was undertaken to assess the suitability of a replacement for the First International Standard for parvovirus B19 IgG, human serum and to calibrate it in IU...
  97. pmc H-1 parvovirus-associated replication bodies: a distinct virus-induced nuclear structure
    C Cziepluch
    Applied Tumor Virology Unit, F0100 and Institut National de la Santé et de la Recherche Médicale U 375, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Virol 74:4807-15. 2000
    We have identified a nuclear structure that is induced after infection with the autonomous parvovirus H-1...
  98. pmc Structural comparison of different antibodies interacting with parvovirus capsids
    Susan Hafenstein
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    J Virol 83:5556-66. 2009
    The structures of canine parvovirus (CPV) and feline parvovirus (FPV) complexed with antibody fragments from eight different neutralizing monoclonal antibodies were determined by cryo-electron microscopy (cryoEM) reconstruction to ..
  99. ncbi Caspase activation is required for permissive replication of Aleutian mink disease parvovirus in vitro
    Sonja M Best
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South Fourth Street, Hamilton, Montana 59840, USA
    Virology 292:224-34. 2002
    Aleutian mink disease parvovirus (ADV) is distinct among the parvoviruses as infection in vivo is persistent, restricted, and noncytopathic...
  100. ncbi Short regions of sequence identity between the genomes of human and rodent parvoviruses and their respective hosts occur within host genes for the cytoskeleton, cell adhesion and Wnt signalling
    Jonathan R Kerr
    Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Gen Virol 87:3567-75. 2006
    ..parvoviruses and their respective hosts, blast searches of the genome sequences of adeno-associated virus, parvovirus B19, mouse parvovirus, the prototype strain and immunosuppressant variant of minute virus of mouse, Kilham rat ..
  101. ncbi Factors associated with pathogen seroprevalence and infection in Rocky Mountain cougars
    Roman Biek
    Wildlife Biology Program, University of Montana, Missoula, Montana 59812, USA
    J Wildl Dis 42:606-15. 2006
    ..Mountains were examined for evidence of current or prior exposure to feline immunodeficiency virus (FIV), feline parvovirus (FPV), feline coronavirus (FCoV), feline calicivirus (FCV), canine distemper virus (CDV), feline herpesvirus (..

Research Grants64

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..are obtained every 3 months and if elevated, patients are again screened for hepatitis B, C, and A;CMV, EBV, Parvovirus, and HIV...
  2. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..NIBSC), London, England, we demonstrated that SuperFluids(tm) CFI can inactivate more than 4 logs of human Parvovirus B19 (one of the smallest and toughest viruses) in human plasma in a two-stage CFI unit in less than 20 seconds...
  3. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..responses using mixed leukocyte cultures, and examining novel T- cell specificities by immunizing with parvovirus, pseudorabies, and tetanus toxoid. Aim 3...
  4. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human parvovirus B19 (B19V) infection causes hydrops fetalis in pregnant women during the second- trimester...
  5. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..is increasing risk of disease transmission from current blood supplies including HIV, Hepatitis A virus, B19 parvovirus, Hepatitis C virus, and infectious prion proteins the agents associated with variant Creutzfeldt-Jakob disease, ..
  6. The Evolutionary and Biological Bases of Host Switching in Viruses
    Colin R Parrish; Fiscal Year: 2013
    ..which represent powerful and experimentally tractable models for human emerging viruses;the emergence of canine parvovirus (CPV) from feline panleukopenia virus (FPV), and the cross-species transfer of H3N8 equine influenza A virus (..
  7. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..viruses, such as HIV, but are not very effective against nonenveloped viruses such as Hepatitis A (HAV) and parvovirus B19...
  8. Glioma immunotherapy with strategies based on autonomous parvovirus MVMp
    JUSTIN COBB PAGLINO; Fiscal Year: 2013
    ..malignant glioma using an oncolytic parovirus combined with therapies that we hypothesize will synergize with parvovirus therapy because they operate by different mechanisms...
  9. Screens for host DNA replication and repair factors involved in viral infection
    Matthew D Weitzman; Fiscal Year: 2010
    ..of Adenovirus (Ad) and Herpes Simplex Virus type 1 (HSV-1), the single-stranded DNA (ssDNA) genome of the parvovirus Adeno-Associated Virus (AAV), and the circular dsDNA genome of Simian Virus type 40 (SV40)...
  10. LuIII parvovirus targets glioma
    Anthony N van den Pol; Fiscal Year: 2013
    ..A number of parvoviruses have been reported to show oncolytic potential against cancer cells, and a rat parvovirus, H-1, is currently in clinical trials to treat glioma patients...
  11. Study of Bone Marrow Failure Caused by B19 Virus Infection
    Jianming Qiu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Parvovirus B19 (B19V) infection causes human bone marrow failure by destroying the bone marrow resident erythroid progenitor cells (EPCs), which support autonomous replication of the virus...
  12. MOLECULAR BASIS OF PARVOVIRAL TARGET CELL SPECIFICITY
    PETER J TATTERSALL; Fiscal Year: 2013
    ..In addition, many parvovirus species that infect rodents are inherently oncoselective, and preferentially infect transformed human cells, ..
  13. Parvovirus RNA Processing and Gene Expression Strategies
    David J Pintel; Fiscal Year: 2013
    ..We have identified three aspects critical for parvovirus replication to pursue in this application. 1...
  14. Adeno-associated Virus RNA Splicing and Polyadenylation
    David J Pintel; Fiscal Year: 2013
    Internal polyadenylation of parvovirus RNA is more prevalent than previously appreciated, and in fact, can be considered the rule rather than the exception as a means to govern parvovirus gene expression...
  15. Parvovirus-Cell Interactions
    David J Pintel; Fiscal Year: 2013
    ..studies demonstrated that AAV engages the host antiviral response, which had not previously been shown for any parvovirus. This application builds on these observations...
  16. Host cell receptor variation and control of viral cross-species transmission
    ANDREW BROWNELL ALLISON; Fiscal Year: 2013
    ..My studies seek to identify the viral, host, and evolutionary mechanisms that governed the emergence of canine parvovirus (CPV) as a new pandemic pathogen...
  17. Structural controls of functional receptor and antibody binding to viral capsids
    Colin R Parrish; Fiscal Year: 2013
    ..Those areas of study are significant because they are features of all animal and human viruses. While parvovirus capsids appear structurally simple, they are clearly sophisticated biomolecular machines that carry out many ..
  18. Structural Studies of Virus and Receptor Interaction
    Susan Hafenstein; Fiscal Year: 2010
    ..The second aim is directed at understanding the asymmetric use of a host protein by a parvovirus. The binding of only one soluble receptor molecule in vitro was unexpected and exciting...
  19. Mechanisms of APOBEC3A Inhibition
    Matthew D Weitzman; Fiscal Year: 2013
    ..We discovered that hA3A can potently inhibit two very different genetic elements: (i) a human parvovirus adeno-associated virus (AAV), and (ii) human and mouse endogenous retroelements...
  20. MOLECULAR GENETICS OF PARVOVIRAL DNA REPLICATION
    PETER J TATTERSALL; Fiscal Year: 2013
    ..The major model we will continue to explore is the autonomous parvovirus Minute Virus of Mice (MVM), a genetically tractable virus that grows in cell culture...
  21. TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESIS
    Colin R Parrish; Fiscal Year: 2010
    ..viral systems, including herpesvirus replication and pathogenesis, influenza and coronavirus cell infection, parvovirus host range, reovirus and calicivirus cell replication mechanisms, retrovirus capsid assembly, baculovirus ..
  22. Engineering altered receptors and antibodies to study viral functions
    LAURA BRUNENGRABER GOODMAN; Fiscal Year: 2010
    ..Construct canine parvovirus (CPV) affinity-altered transferrin receptors and determine their effect on capsid binding and cell infectivity...
  23. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..Adeno-associated parvovirus (AAV) vectors will then be designed to contain the GABRA4 promoter driving the transcription of GABRA1 transgene ..
  24. SURROGATE ASSAY FOR B19 PARVOVIRUS SERUM NEUTRALIZATION
    GEETHA BANSAL; Fiscal Year: 1990
    b>Parvovirus B19 is implicates as a cause of human disease syndromes including mild illness with rash in children (erythema infectiosum), febrile illness with arthralgia or arthritis in adults, serious transient or chronic aplastic anemia ..
  25. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2004
    ..The adeno-associated virus 2 (AAV2), a non-pathogenic human parvovirus, has gained attention as a potentially useful vector...
  26. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2002
    ..The adeno-associated virus 2 (AAV2), a non-pathogenic human parvovirus, has gained attention as a potentially useful vector...
  27. Enhancing Gene Therapy by Designing Chimeric AAV Virions
    JARROD JOHNSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Adeno-associated virus (AAV), a non-pathogenic parvovirus, is an attractive vehicle for gene therapy...
  28. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
    ..at Cornell University and Purdue University which involve genetic, virological, and structural studies of parvovirus capsids, their cellular receptors, and the antibodies that neutralize them...
  29. AAV DIRECTED MUSCLE GENE THERAPY FOR HEMOPHILIA B
    Paul Monahan; Fiscal Year: 2003
    The adeno-associated virus (AAV) is a dependent parvovirus whose unique biology recommends it as a safe and efficient vector for gene therapy...
  30. NONINVASIVE DETECTION OF ANTIBODIES AGAINST HPV
    Michael Hagensee; Fiscal Year: 2000
    ..Numerous antibodies against viral pathogens (hepatitis, measles, mumps, rubella, parvovirus, and HIV) have been detected in oral fluids and reliably reflect the serum status of these individuals...
  31. RAAV TRANSDUCTION IN HUMAN HEMATOPOIETIC STEM CELL
    RICHARD SAMULSKI; Fiscal Year: 2000
    ..We are engaged in studying the molecular biology of the defective human parvovirus adeno-associated virus (AAV) in hopes of developing a safe and efficient viral vector for human gene therapy...
  32. DETERMINANTS OF PARVOVIRUS ASSEMBLY AND INFECTIVITY
    IAN MAXWELL; Fiscal Year: 2000
    The parvoviruses are small, structurally simple, single strand DNA viruses. At least one parvovirus (B19) is a human pathogen, implicated in a disease spectrum from aplastic crises to hydrops fetalis...
  33. INCIDENCE & IDENTITY OF THE RA-1 PARVOVIRUS
    Robert Simpson; Fiscal Year: 1990
    The B19 parvovirus causes at least three human diseases including a non-destructive polyarthralgia in adults and in presently the only recognized human pathogen of this virus group...
  34. Biowarfare applications of a new immunoregulator
    KENNETH WILLEFORD; Fiscal Year: 2003
    ..activity, yet retain the ability to abate viral pathogenesis as presented in a West Nile Virus mouse model and a Parvovirus rat model...
  35. PATHOGENESIS AND THERAPY OF B19-INDUCED HYDROPS FETALIS
    Cathy Carlson; Fiscal Year: 2000
    Using a monkey model of human B19 parvovirus infection, the long term objectives are to clarify the pathogenesis of hydrops fetalis caused by B19 parvovirus, and to develop appropriate therapeutic regimens for this condition...
  36. MODEL FOR EMERGENCE OF PARVOVIRUS B19 VIRULENCE
    STANLEY NAIDES; Fiscal Year: 1999
    Human parvovirus B19 causes well described clinical disease. The association of parvovirus B19 infection with well known but previously considered idiopathic disease qualifies B19 as an ~emerging~ pathogen...
  37. AUTONOMOUS PARVOVIRUS VECTORS FOR CANCER THERAPY
    IAN MAXWELL; Fiscal Year: 1992
    ....
  38. STRUCTURE/FUNCTION RELATIONS IN PARVOVIRUS CELL BINDING
    STANLEY NAIDES; Fiscal Year: 2000
    DESCRIPTION: Human parvovirus B19 causes a spectrum of clinical syndromes...
  39. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS B19 IGG/M
    PAUL MARIE HONHON; Fiscal Year: 1990
    The Human Parvovirus B19 is the agent of several disease states: erythema contagiosum, a transient arthritis, and aplastic crisis in sickle cell anemia patients, and hydrops fetalis (a usually fatal outcome of pregnan- cy)...
  40. HUMAN PARVOVIRUS B19
    Arun Srivastava; Fiscal Year: 1992
    ..of the proposed research is to study the molecular events associated with the life-cycle of the human pathogenic parvovirus B19 believed to be the etiologic agent for several human diseases such as erythema infectiosum, transient ..
  41. RECEPTORS AND ENTRY PROCESS OF CANINE PARVOVIRUS
    SUKLA CHATTOPADHYAY; Fiscal Year: 1993
    ..Moreover, a human parvovirus, B19, has recently been identified which has been associated with several clinical disorders including "fifth ..
  42. INFECTIOUS ENTRY PATHWAY OF AAV VECTORS
    Jeffrey Bartlett; Fiscal Year: 2001
    ..Dr. Bartlett's laboratory is engaged in studying the biology of the defective parvovirus, adeno-associated virus (AAV) in hopes of developing a safe and efficient viral vector for gene therapy...
  43. STRATEGIES TO IMPROVE AAV CFTR PERSISTENCE & EXPRESSION
    Terence Flotte; Fiscal Year: 1999
    DESCRIPTION (Taken directly from the application) Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has been developed as a gene transfer vector for cystic fibrosis...
  44. SITE SPECIFIC INTEGRATION BY ADENO ASSOCIATED VIRUS
    Genovefa Papanicolaou; Fiscal Year: 2003
    The human parvovirus adeno-associated virus (AAV) is non-pathogenic and integrates into a defined region of chromosome 19 to establish latency...
  45. MOLECULAR GENETICS OF AND GENE THERAPY FOR DEAFNESS
    Anil Lalwani; Fiscal Year: 2000
    ..component of this proposal is to assess the utility of adeno-associated virus (AAV, a non-pathogenic human parvovirus) in introducing genetic material into the neuroepithelia of the inner ear...
  46. MODEL DEVELOPMENT FOR B19 PARVOVIRUS FETAL INFECTION
    M O SULLIVAN; Fiscal Year: 1999
    A new simian parvovirus (SPV) that is remarkably similar to the human B19 parvovirus, both in terms of the virus genome and clinical disease resulting from natural infection, has been discovered...
  47. MOLECULAR GENETICS OF PARVOVIRAL DNA REPLICATION
    PETER J TATTERSALL; Fiscal Year: 2010
    ..The major model we will continue to explore is the autonomous parvovirus Minute Virus of Mice (MVM), a genetically tractable virus that grows in cell culture...
  48. INTERNATIONAL CONFERENCE--PARVOVIRUS
    KENNETH BERNS; Fiscal Year: 1993
    This is an application for support for an International meeting on Parvovirus. Almost all US citizens have been infected by the tide of adulthood by two types of parvoviruses; one that can replicate autonomously in cell culture and a ..
  49. New Model For Virus Induced Autoimmunity
    Dennis Guberski; Fiscal Year: 2004
    ..to induction of autoimmune diabetes by a variety of methods including intraperitoneal injection of rat parvovirus (KRV), antibody depletion of regulatory T cells, administration of low dose Poly I:C, and injection of rat ..
  50. MECHANISM OF HEMATPOIETIC SUPPRESSION IN HIV-1 INFECTION
    Ronald Hoffman; Fiscal Year: 1993
    ..In addition, the effect of two other viral pathogens, cytomegalovirus (CMV) and the human parvovirus B19 (HPV-B19) on hematopoiesis in AIDS patients will also be examined...
  51. VIRUS INACTIVATION OF HUMAN RED CELLS FOR TRANSFUSION
    CLARK EDSON; Fiscal Year: 1999
    ..killing of a number of different enveloped and non-enveloped viruses, including model viruses for human Bl9 parvovirus and hepatitis C virus...
  52. Autonomous Parvovirus Vectors for Gene Targeting
    PAUL HENDRIE; Fiscal Year: 2006
    ..The research will focus on the process of the gene targeting using parvovirus vectors...
  53. CHARACTERIZATION OF HEREDITARY CEREBELLAR ATAXIA
    DANIEL TOLBERT; Fiscal Year: 1991
    ..The breeding colony has remained free of murine pathogens including "rat parvovirus other"...
  54. IN VITRO INACTIVATION OF VIRUSES IN BLOOD COMPONENTS
    Daniel Meruelo; Fiscal Year: 1999
    ..These studies have implications for potential inactivation of non enveloped viruses (such as B19 parvovirus) in blood by HY...
  55. VIRAL INACTIVATION OF INTRAVENOUS IMMUNOGLOBULIN (IVIG)
    CLARK EDSON; Fiscal Year: 1999
    ..plasma derivatives contaminated with pathogenic viruses like HIV, hepatitis C (HCV), hepatitis A (HAV) and parvovirus Bl9...
  56. Regulation of AAV Rep Protein Function
    JAMES TREMPE; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Adeno-associated Virus (AAV) is a nonpathogenic, defective human parvovirus. AAV requires that a helper virus co-infect the host cell for efficient virus replication...
  57. INDUCTION OF PERSISTENT IMMUNITY BY PARVOVIRAL VECTORS
    Peter Tattersall; Fiscal Year: 2001
    ..We will use vectors packaged in the coat of the murine lymphotropic parvovirus MVMi to target foreign antigen expression to a very small fraction of T-cells in the host...
  58. AAV-SPECIFIC INTEGRATION AND RESCUE IN HUMAN CELLS
    RICHARD SAMULSKI; Fiscal Year: 1992
    Adeno-associated virus is a dependent parvovirus requiring coinfection with another virus in order to undergo a productive infection in cultured cells...
  59. Placental Immunity to LCMV
    Elizabeth A Bonney; Fiscal Year: 2010
    ..Based on existing data about human infection with Cytomegalovirus, Rubella, and Parvovirus we assert that placental and viral factors, as well as maternal immunity affect the overall outcome of viral ..
  60. PERSISTENT AND PRENATAL PARVOVIRUS INFECTION
    Robert Jacoby; Fiscal Year: 2000
    ..The proposed research will explore nonlethal infection caused by rat virus (RV), the prototypic rat parvovirus, in established models of persistent and prenatal infection, and will emphasize the pathogenesis of persistent ..
  61. CIS-REQUIREMENTS FOR RECOMBINANT AAV PRODUCTION
    R Linden; Fiscal Year: 2001
    ..We propose to test the hypothesis that the ITRs of a different parvovirus can be used to achieve this goal...
  62. PARVOVIRUS INFECTION
    Robert Jacoby; Fiscal Year: 1991
    Rat virus is a common parvovirus of rats that can cause severe or lethal infection or distort biological responses that require the synthesis of DNA...
  63. MOLECULAR AND GENETIC ANALYSIS OF PARVOVIRUS REPLICATION
    David Ward; Fiscal Year: 1992
    The major objective of this proposal is to determine the mechanism(s) of autonomous parvovirus transcription, at the molecular and enzymatic level, using the fibrotropic (p) and lymphotropic (i) variants of Minute Virus of Mice (MVM) and ..
  64. EVENTS OF PARVOVIRUS AND ANIMAL CELL DNA SYNTHESIS
    RICHARD ARMENTROUT; Fiscal Year: 1980
    We propose to use the parvovirus MVM as a means of investigating the events of eukaryotic DNA synthesis as they occur in vivo...