human parvovirus b19

Summary

Summary: The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.

Top Publications

  1. ncbi Simultaneous persistence of multiple genome variants of human parvovirus B19
    Beate Schneider
    Institute of Virology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Gen Virol 89:164-76. 2008
  2. ncbi Slow clearance of human parvovirus B19 viremia following acute infection
    Anna Lindblom
    Department of Medicine, Infectious Disease Unit, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Clin Infect Dis 41:1201-3. 2005
  3. pmc Human parvovirus B19
    Erik D Heegaard
    Department of Clinical Microbiology, University State Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Microbiol Rev 15:485-505. 2002
  4. ncbi Parvovirus B19
    Neal S Young
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1652, USA
    N Engl J Med 350:586-97. 2004
  5. ncbi Human parvovirus B19 infection and autoimmunity
    Claudio Lunardi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Autoimmun Rev 8:116-20. 2008
  6. ncbi Childhood chorea-encephalopathy associated with human parvovirus B19 infection
    Choong Yi Fong
    Department of Neurology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Dev Med Child Neurol 48:526-8. 2006
  7. ncbi Anti-human parvovirus B19 nonstructural protein antibodies in patients with rheumatoid arthritis
    Bor Show Tzang
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    Clin Chim Acta 405:76-82. 2009
  8. ncbi Frequency of transmission of human parvovirus B19 infection by fibrin sealant used during thoracic surgery
    Masafumi Kawamura
    Division of General Thoracic Surgery, Keio University Hospital, Tokyo, Japan
    Ann Thorac Surg 73:1098-100. 2002
  9. ncbi Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients
    Chang Seok Ki
    Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Clin Transplant 19:751-5. 2005
  10. pmc Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G(1) phase
    Eiji Morita
    Department of Microbiology and Immunology, School of Medicine, Tohoku University, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Virol 77:2915-21. 2003

Research Grants

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  2. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
  3. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
  4. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
  5. MODEL FOR EMERGENCE OF PARVOVIRUS B19 VIRULENCE
    STANLEY NAIDES; Fiscal Year: 1999
  6. HUMAN PARVOVIRUS B19
    Arun Srivastava; Fiscal Year: 1992
  7. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS B19 IGG/M
    PAUL MARIE HONHON; Fiscal Year: 1990
  8. STRUCTURE/FUNCTION RELATIONS IN PARVOVIRUS CELL BINDING
    STANLEY NAIDES; Fiscal Year: 2000
  9. RECEPTORS AND ENTRY PROCESS OF CANINE PARVOVIRUS
    SUKLA CHATTOPADHYAY; Fiscal Year: 1993
  10. MECHANISM OF HEMATPOIETIC SUPPRESSION IN HIV-1 INFECTION
    Ronald Hoffman; Fiscal Year: 1993

Detail Information

Publications259 found, 100 shown here

  1. ncbi Simultaneous persistence of multiple genome variants of human parvovirus B19
    Beate Schneider
    Institute of Virology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Gen Virol 89:164-76. 2008
    The species human parvovirus B19 (B19V) can be divided into three genotypes. In this study, we addressed the question as to whether infection of an individual is restricted to one genotype...
  2. ncbi Slow clearance of human parvovirus B19 viremia following acute infection
    Anna Lindblom
    Department of Medicine, Infectious Disease Unit, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Clin Infect Dis 41:1201-3. 2005
    ..These findings challenge our current conception of the virus' pathogenesis and have implications for the management of the infection...
  3. pmc Human parvovirus B19
    Erik D Heegaard
    Department of Clinical Microbiology, University State Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Microbiol Rev 15:485-505. 2002
    ..Treatment of persistent infection with immunoglobulin reduces the viral load and results in a marked resolution of anemia. Vaccine phase I trials show promising results...
  4. ncbi Parvovirus B19
    Neal S Young
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1652, USA
    N Engl J Med 350:586-97. 2004
  5. ncbi Human parvovirus B19 infection and autoimmunity
    Claudio Lunardi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Autoimmun Rev 8:116-20. 2008
    b>Human parvovirus B19 infection is responsible for a wide range of human diseases ranging from mild erythema infectiosum in immunocompetent children to fetal loss in primary infected pregnant women and aplastic anemia or lethal cytopenias ..
  6. ncbi Childhood chorea-encephalopathy associated with human parvovirus B19 infection
    Choong Yi Fong
    Department of Neurology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Dev Med Child Neurol 48:526-8. 2006
    ..During the clinical course, genomic human parvovirus B19 DNA was detected in her serum and CSF...
  7. ncbi Anti-human parvovirus B19 nonstructural protein antibodies in patients with rheumatoid arthritis
    Bor Show Tzang
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    Clin Chim Acta 405:76-82. 2009
    ..reported the association between the development of NS1-specific IgG and arthropathy after the infection of human parvovirus B19 (B19). However, the role of anti-B19-NS1 IgG in RA is still unclear...
  8. ncbi Frequency of transmission of human parvovirus B19 infection by fibrin sealant used during thoracic surgery
    Masafumi Kawamura
    Division of General Thoracic Surgery, Keio University Hospital, Tokyo, Japan
    Ann Thorac Surg 73:1098-100. 2002
    ..Although pasteurization is insufficient to remove human parvovirus (HPV) B19 from this plasma-derived product, the frequency of HPV B19 infection transmitted by its use has never been known...
  9. ncbi Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients
    Chang Seok Ki
    Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Clin Transplant 19:751-5. 2005
    b>Human parvovirus B19 (B19) infection has been known to cause chronic anemia, pure red cell aplasia (PRCA), glomerulopathy, and allograft dysfunction in kidney transplant (KT) recipients...
  10. pmc Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G(1) phase
    Eiji Morita
    Department of Microbiology and Immunology, School of Medicine, Tohoku University, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Virol 77:2915-21. 2003
    b>Human parvovirus B19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. This erythroid cell damage is mediated by the viral nonstructural protein 1 (NS1) through an apoptotic mechanism...
  11. pmc Molecular and functional analyses of a human parvovirus B19 infectious clone demonstrates essential roles for NS1, VP1, and the 11-kilodalton protein in virus replication and infectivity
    Ning Zhi
    Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    J Virol 80:5941-50. 2006
    ..These findings suggest a previously unrecognized role for the 11-kDa protein, and together the results enhance our understanding of the key features of the B19 viral genome and proteins...
  12. ncbi Construction and sequencing of an infectious clone of the human parvovirus B19
    Ning Zhi
    Hematology Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Virology 318:142-52. 2004
    b>Human parvovirus B19 has a nonenveloped, icosahedral capsid packaging a linear single-stranded DNA genome of 5.6 kb with long inverted terminal repeats (ITR) at both the 5' and 3' end...
  13. ncbi Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19
    Amanda Corcoran
    National Institute for Cellular Biotechnology, Department of Biology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    J Med Microbiol 53:459-75. 2004
    ....
  14. ncbi Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection
    Philipp von Landenberg
    Klinik and Poliklinik fur Innere Medizin I, Universitatsklinikum Regensburg, Regensburg, Germany
    Arthritis Rheum 48:1939-47. 2003
    ..To show a possible association between parvovirus B19 infection and the presence of antiphospholipid antibodies (aPL) in patients with rheumatic diseases...
  15. pmc Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells
    T C Hsu
    Institute of Immunology, Chung Shan Medical University, Taichung, Taiwan
    Clin Exp Immunol 144:152-7. 2006
    b>Human parvovirus B19 (B19) has been associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
  16. ncbi Presentation, patterns of myocardial damage, and clinical course of viral myocarditis
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Circulation 114:1581-90. 2006
    ..Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples...
  17. pmc Characterization of erythrovirus B19 genomes isolated in liver tissues from patients with fulminant hepatitis and biliary atresia who underwent liver transplantation
    Kenji Abe
    Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Int J Med Sci 4:105-9. 2007
    ..We investigated whether or not erythrovirus B19 is a candidate etiologic agent in such liver disease patients who had undergone liver transplantation...
  18. ncbi Clinical presentations of parvovirus B19 infection
    Jessica T Servey
    David Grant Medical Center, Travis Air Force Base, California 94535, USA
    Am Fam Physician 75:373-6. 2007
    ..Treatment is usually supportive, although some patients may require transfusions or intravenous immune globulin therapy. Most patients recover completely...
  19. ncbi Parvovirus B19 nonstructural (NS1) protein as a transactivator of interleukin-6 synthesis: common pathway in inflammatory sequelae of human parvovirus infections?
    Leslie Ann Mitchell
    Department of Pathology, University of British Columbia, Vancouver, Canada
    J Med Virol 67:267-74. 2002
    This review focuses on the role that human parvovirus B19 nonstructural (NS1) protein as a transactivator of the proinflammatory cytokine, interleukin-6 (IL-6), might play in triggering the multiparametric inflammatory outcomes of B19 ..
  20. ncbi Parvovirus B19 and autoimmune diseases
    Olivier Meyer
    Rheumatology Department, Hopital Bichat, 46, rue Henri Huchard, 75018 Paris, France
    Joint Bone Spine 70:6-11. 2003
    ..Here again, the number of clinical cases is small...
  21. ncbi Lupus-like presentation of parvovirus B19 infection
    Pascal Seve
    Department of Internal Medicine, Hotel Dieu, Hospices Civils de Lyon, Universite Claude Bernard Lyon I, France
    Semin Arthritis Rheum 34:642-8. 2005
    ..To describe 2 cases of parvovirus B19 (B19) infection mimicking systemic lupus erythematosus (SLE) and to identify all cases of SLE imitated by and/or associated with B19 in the medical literature...
  22. pmc Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells
    Anja Duechting
    Department of Molecular Pathology, Institute for Pathology, University of Tuebingen, 72076 Tuebingen, Germany
    J Virol 82:7942-52. 2008
    ..Thus, NS1 may play a critical role in the mechanism of viral pathogenesis in B19-associated iCMP...
  23. pmc The genome of human parvovirus b19 can replicate in nonpermissive cells with the help of adenovirus genes and produces infectious virus
    Wuxiang Guan
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, USA
    J Virol 83:9541-53. 2009
    b>Human parvovirus B19 (B19V) is a member of the genus Erythrovirus in the family Parvoviridae...
  24. pmc Recombinant human parvovirus B19 vectors: erythrocyte P antigen is necessary but not sufficient for successful transduction of human hematopoietic cells
    K A Weigel-Kelley
    Department of Microbiology and Immunology, Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA
    J Virol 75:4110-6. 2001
    ..These studies further suggest the existence of a putative cellular coreceptor for efficient entry of parvovirus B19 into human cells...
  25. ncbi Human parvovirus B19, varicella zoster virus, and human herpesvirus-6 in mesenchymal stem cells of patients with osteoarthritis: analysis with quantitative real-time polymerase chain reaction
    R Rollin
    Servicio de Reumatologia, Hospital Clinico San Carlos, and Departamento de Biología Molecular, Centro de Biologia Molecular, Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Osteoarthritis Cartilage 15:475-8. 2007
    ..The presence of parvovirus B19 (B19), varicella zoster virus (VZV), and human herpesvirus-6 (HHV-6) was studied in MSCs from bone marrow of patients with OA and healthy controls...
  26. ncbi Generation of multifunctional murine monoclonal antibodies specifically directed to the VP1unique region protein of human parvovirus B19
    Maik D Drechsler
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg Universität Mainz Klinikum, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunobiology 213:511-7. 2008
    Little is known about the VP1unique region (VP1u), a part of one major capsid protein of human parvovirus B19 (B19), concerning its involvement in viral replication and infection cycle...
  27. ncbi Recombinant human parvovirus B19 vectors
    Kirsten A Weigel-Kelley
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pathol Biol (Paris) 50:295-306. 2002
    In an attempt to exploit the remarkable tissue-tropism of the human parvovirus B19 to target human hematopoietic cells of the erythroid lineage, recombinant human adeno-associated virus 2 genomes were encapsidated in parvovirus B19 ..
  28. doi Kinetics of inactivating human parvovirus B19 and porcine parvovirus by dry-heat treatment
    Johannes Blümel
    Transfusion 48:790. 2008
  29. pmc The structure of human parvovirus B19
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 101:11628-33. 2004
    b>Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3...
  30. pmc Increased expression of Matrix Metalloproteinase 9 in liver from NZB/W F1 mice received antibody against human parvovirus B19 VP1 unique region protein
    Chun Chou Tsai
    Institute of Immunology, Chung Shan Medical University, Taichung, Taiwan
    J Biomed Sci 16:14. 2009
    b>Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure.
  31. ncbi Human parvovirus B19: relevance in internal medicine
    A M van Elsacker-Niele
    Department of Medical Microbiology, Public Health Laboratory, Leeuwarden, The Netherlands
    Neth J Med 54:221-30. 1999
    Infection by the human parvovirus B19 can lead to several clinical manifestations which are relevant in internal medicine...
  32. pmc High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy
    Thomas Schenk
    Department of Virology, University Medical Center, Freiburg, Hermann Herder Str 11, 79104 Freiburg, Germany
    J Clin Microbiol 47:106-10. 2009
    b>Human parvovirus B19 has been linked to a variety of cardiac diseases, as well as to erythema infectiosum, acute arthropathy, and fetal hydrops...
  33. ncbi Serologic and molecular detection of human Parvovirus B19 infection
    Dimitri Peterlana
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chim Acta 372:14-23. 2006
    Following its identification by Yvonne Cossart in 1975, human Parvovirus B19 has been recognized as the causative agent of a wide range of diseases...
  34. ncbi Acute endocapillary proliferative glomerulonephritis associated with human parvovirus B19 infection
    Y Iwafuchi
    Department of Internal Medicine, Koseiren Sanjo General Hospital, Sanjo, Japan
    Clin Nephrol 57:246-50. 2002
    A 36-year-old female developed acute nephritic syndrome associated with human parvovirus B19 (HPVB19) infection...
  35. ncbi Pityriasis lichenoides: a cytotoxic T-cell-mediated skin disorder. Evidence of human parvovirus B19 DNA in nine cases
    Dario Tomasini
    Department of Dermatology, Hospital of Busto Arsizio, Piazza Solaro 3, I 21052 Busto Arsizio, Italy
    J Cutan Pathol 31:531-8. 2004
    ..Furthermore, monoclonal rearrangement of the T-cell receptor-gamma (TCR-gamma) genes was repeatedly found both in PLEVA and PLC...
  36. pmc Human parvovirus B19 nonstructural protein NS1 enhanced the expression of cleavage of 70 kDa U1-snRNP autoantigen
    Bor Show Tzang
    Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Biomed Sci 17:40. 2010
    b>Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders...
  37. ncbi Chronic fatigue syndrome after human parvovirus B19 infection without persistent viremia
    Mariko Seishima
    Department of Dermatology, Ogaki Municipal Hospital, Ogaki City, Japan
    Dermatology 216:341-6. 2008
    It is unclear how often chronic fatigue syndrome (CFS) appears after human parvovirus B19 (B19) infection and whether prolonged B19 viremia or some other factors cause CFS.
  38. pmc Comparison of three commercially available serologic assays used to detect human parvovirus B19-specific immunoglobulin M (IgM) and IgG antibodies in sera of pregnant women
    Allyson R Butchko
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Microbiol 42:3191-5. 2004
    ..performances of three enzyme immunoassays (EIAs) utilizing one or more conformational antigens to detect human parvovirus B19 (B19V)-specific immunoglobulin M (IgM) or IgG in the sera of 198 pregnant women...
  39. pmc Persistence of human parvovirus B19 in multipotent mesenchymal stromal cells expressing the erythrocyte P antigen: implications for transplantation
    Mikael Sundin
    Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 14:1172-9. 2008
    ..These findings demonstrate for the first time that persistent B19 in MSCs can infect hematopoietic stem cells and underscore the importance of monitoring B19 transmission by MSC products...
  40. ncbi Phylogenetic analysis of human parvovirus B19, indicating two subgroups of genotype 1 in Vietnamese patients
    Nguyen L Toan
    Department of Molecular Pathology, Institute of Pathology, University Hospital of Tubingen, 72076 Tubingen, Germany
    J Gen Virol 87:2941-9. 2006
    Recently, three distinct genotypes (1, 2 and 3) of human parvovirus B19 (B19) have been identified. However, the characteristics and distribution of B19 genotypes in Vietnam have not been investigated...
  41. ncbi [Eight cases of human parvovirus B19 arthropathy]
    Yoshito Yoshidome
    Department of Neurology, Imakiire General Hospital, Kagoshima
    Nihon Naika Gakkai Zasshi 93:377-9. 2004
  42. pmc CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells
    Yong Mei Guo
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Blood 115:4569-79. 2010
    ..These features were similar to those observed in erythroid progenitors infected with human parvovirus B19 that causes pure red cell aplasia...
  43. ncbi Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: prospective evaluation of 1018 cases
    Martin Enders
    Labor Enders und Partner, Institut fur Virologie, Infektiologie und Epidemiologie e V, Stuttgart, Germany
    Prenat Diagn 24:513-8. 2004
    ..To determine more precisely the incidence of fetal complications following maternal parvovirus B19 infection at various gestational ages...
  44. ncbi No evidence of parvovirus B19, Chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis
    J Helweg-Larsen
    Department of Infectious Diseases, Hvidovre University Hospital, Denmark
    Rheumatology (Oxford) 41:445-9. 2002
    ..We investigated temporal arteries from patients with GCA for these infections as well as human herpes viruses using the polymerase chain reaction (PCR)...
  45. ncbi [Severe anaemia caused by Human Parvovirus B19 infection in a patient with autoimmune haemolytic anaemia and a B-cell non-Hodgkin lymphoma]
    I E van Dam
    Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef, Amsterdam
    Ned Tijdschr Geneeskd 152:153-7. 2008
    ..To prevent transmission of Human Parvovirus B19 via blood transfusion, the Health Council of the Netherlands published a guideline indicating that patients ..
  46. ncbi Human parvovirus B19 in patients with aplastic anemia
    Baijayantimala Mishra
    Department of Virology, Post Graduate Institute of Medical Education and Research, 160012 Chandigarh, India
    Am J Hematol 79:166-7. 2005
    ..Various factors including viral infections have been implicated as the precipitating factors. Human parvovirus B19 has been associated with red-cell aplasia, leukopenia, and thrombocytopenia...
  47. ncbi Frequency of human parvovirus B19 infection in intrauterine fetal death
    T Tolfvenstam
    Departments of Clinical Virology, Karolinska Institutet, Huddinge University Hospital, SE 141 86, Stockholm, Sweden
    Lancet 357:1494-7. 2001
    ..We aimed to investigate the frequency of parvovirus B19 infection in unselected cases of intrauterine fetal death and to assess the sensitivity of different diagnostic procedures...
  48. ncbi Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, SW3 6NP London, United Kingdom
    J Infect Dis 186:447-52. 2002
    To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic ..
  49. pmc Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors
    Zhihong Wan
    Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1652, USA
    J Clin Invest 120:3530-44. 2010
    b>Human parvovirus B19 (B19V) is the only human pathogenic parvovirus. It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in children and pure red cell aplasia in immunocompromised patients...
  50. pmc Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2
    Yi Fu
    Division of Rheumatology and Hematology, Department of Clinical Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
    J Virol 76:5395-403. 2002
    b>Human parvovirus B19 frequently causes acute and chronic arthritis in adults. The molecular mechanism of B19 arthritis, however, remains poorly understood...
  51. ncbi Clinical aspects of parvovirus B19 infection
    K Broliden
    Department of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Intern Med 260:285-304. 2006
    ..Recent advances in diagnosis and pathogenesis, new insights in the cellular immune response and newly discovered genotypes of human parvoviruses form a platform for the development of modern therapeutic and prophylactic alternatives...
  52. pmc Human parvovirus B19 induces cell cycle arrest at G(2) phase with accumulation of mitotic cyclins
    E Morita
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
    J Virol 75:7555-63. 2001
    b>Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias...
  53. ncbi Identification and genetic diversity of two human parvovirus B19 genotype 3 subtypes
    Armen Parsyan
    Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK
    J Gen Virol 88:428-31. 2007
    Three genotypes (1-3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters...
  54. ncbi Association of parvovirus B19 infection and Hashimoto's thyroiditis in children
    Hartwig W Lehmann
    Department of Pediatrics, University of Giessen, Giessen, Germany
    Viral Immunol 21:379-83. 2008
    ..01). There is strong evidence that acute parvovirus B19 infections are involved in the pathogenesis of some cases of Hashimoto's thyroiditis...
  55. ncbi The prevalence and persistence of human parvovirus B19 infection in thalassemic patients
    Sontana Siritantikorn
    Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 25:169-74. 2007
    b>Human parvovirus B19 infection was studied in 60 thalassemic patients in Thailand. Seroprevalence, persistence of parvovirus B19 and their genotypes were identified in blood samples...
  56. ncbi Establishment of the first World Health Organization International Standard for human parvovirus B19 DNA nucleic acid amplification techniques
    J Saldanha
    Division of Virology, National Institute for Biological Standards and Controls, South Mimms, Herts, UK
    Vox Sang 82:24-31. 2002
    ..study, involving 26 laboratories from 14 countries, was carried out in order to establish a World Health Organization (WHO) International Standard for human parvovirus B19 (B19) DNA nucleic acid amplification techniques (NAT).
  57. ncbi Tissue persistence of parvovirus B19 genotypes in asymptomatic persons
    Fabiana Corcioli
    Department of Public Health, University of Firenze, Italy
    J Med Virol 80:2005-11. 2008
    ..The results suggest that the virus persists without replicating, at sub-immunogenic levels...
  58. ncbi Functional analysis and quantitative determination of the expression profile of human parvovirus B19
    Francesca Bonvicini
    Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, Via Massarenti, 9I 40138 Bologna, Italy
    Virology 381:168-77. 2008
    Comprehension of the pathogenetic potential of human parvovirus B19 requires the definition of the complete spectrum of cellular tropism and a functional analysis of the viral genome in infected cells...
  59. ncbi Infection of the erythroid cell line, KU812Ep6 with human parvovirus B19 and its application to titration of B19 infectivity
    E Miyagawa
    Ube Research Laboratories, Fujirebio Inc, Yamaguchi, Japan
    J Virol Methods 83:45-54. 1999
    A human parvovirus B19 (B19) infectivity assay was developed using the erythroid cell line, KU812Ep6...
  60. pmc The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells
    Aaron Yun Chen
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Blood 115:1070-80. 2010
    b>Human parvovirus B19 (B19V) infection shows a strong erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the disease outcomes associated with B19V infection...
  61. ncbi Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis
    Chun Wang
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Med Virol 81:2079-88. 2009
    ..These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C...
  62. pmc Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia
    J R Kerr
    Department of Microbiology, Royal Brompton Hospital, Imperial College London, Sydney Street, London SW3 6NP, UK
    J Clin Pathol 56:873-5. 2003
    ..To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia...
  63. ncbi Parvovirus infection, malaria, and anemia in the tropics--a new hidden enemy?
    Geoffrey Pasvol
    J Infect Dis 194:141-2. 2006
  64. ncbi Human parvovirus B19 infection and antiphospholipid-syndrome: the two sides of one medal?
    P Landenberg
    Institut für Klinische Chemie und Laboratoriumsmedizin der Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Vet Med B Infect Dis Vet Public Health 52:353-5. 2005
  65. ncbi Contamination of coagulation factor concentrates with human parvovirus B19 genotype 1 and 2
    Beate Schneider
    Institute of Medical Microbiology and Immunology, University of Bonn, Germany
    Thromb Haemost 92:838-45. 2004
    b>Human parvovirus B19 (B19) DNA has frequently been detected in plasma-derived coagulation factor concentrates...
  66. ncbi T lymphocyte responses against human parvovirus B19: small virus, big response
    Paul Klenerman
    Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Pathol Biol (Paris) 50:317-25. 2002
    ....
  67. pmc Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans
    Oscar Norbeck
    Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08 03, SE 17177 Stockholm, Sweden
    J Virol 79:12117-21. 2005
    ..To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals...
  68. ncbi Neurological manifestations of human parvovirus B19 infection
    Faraj Barah
    Laboratory Medicine Academic Group, University of Manchester, Clinical Sciences Building 3rd Floor, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Rev Med Virol 13:185-99. 2003
    Since its discovery, human parvovirus B19 has been linked with a broad spectrum of clinical syndromes...
  69. pmc Rapid sequence change and geographical spread of human parvovirus B19: comparison of B19 virus evolution in acute and persistent infections
    Päivi Norja
    Center for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Virol 82:6427-33. 2008
    ..Determining what epidemiological or biological factors led to such a complete and geographically extensive population replacement over this short period is central to further understanding the nature of parvovirus evolution...
  70. pmc Prolonged activation of virus-specific CD8+T cells after acute B19 infection
    Adiba Isa
    Institution for Medicine, Infectious Disease Unit, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS Med 2:e343. 2005
    b>Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death...
  71. ncbi Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen)
    K E Brown
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892
    N Engl J Med 330:1192-6. 1994
    ..CONCLUSIONS. People who do not have P antigen, which is the cellular receptor for parvovirus B19, are naturally resistant to infection with this pathogen...
  72. ncbi Human parvovirus B19 infection of monocytic cell line U937 and antibody-dependent enhancement
    Yasuhiko Munakata
    Division of Rheumatology and Hematology, Department of Clinical Medicine, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Virology 345:251-7. 2006
    b>Human parvovirus B19 (B19) infects human erythroid lineage cells. Accumulating evidence also shows that B19 is detectable in nonerythroid lineage cells in vivo, but the mechanism of infection is still not clear...
  73. ncbi Lymphocyte recognition of human parvovirus B19 non-structural (NS1) protein: associations with occurrence of acute and chronic arthropathy?
    L A Mitchell
    Department of Pathology, University of British Columbia, BC Research Institute for Children s and Women s Health, Vancouver, Canada
    J Med Microbiol 50:627-35. 2001
    ..Hence, immune recognition of NS1 may be more indicative of recent infection with, or exposure to, parvovirus B19 than associated with development of arthropathy as previously reported...
  74. pmc Apoptosis of liver-derived cells induced by parvovirus B19 nonstructural protein
    Brian D Poole
    Huck Institutes for Life Sciences, Department of Medicine, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Virol 80:4114-21. 2006
    ..These results demonstrate that NS1 is sufficient to induce apoptosis in liver-derived cells and that it does so through the initiation of an intrinsic caspase pathway...
  75. pmc Parvovirus B19-induced apoptosis of hepatocytes
    Brian D Poole
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Virol 78:7775-83. 2004
    ..Inhibition studies demonstrated that caspases 3 and 9, but not caspase 8, are required for B19 virus-induced apoptosis...
  76. ncbi Different patterns of disease manifestations of parvovirus B19-associated reactive juvenile arthritis and the induction of antiphospholipid-antibodies
    Hartwig W Lehmann
    Department of Pediatrics, University of Giessen, Giessen, Germany
    Clin Rheumatol 27:333-8. 2008
    ..In consequence, parvovirus B 19 should generally be taken into consideration as a trigger of various forms of juvenile arthritis and persistence of infection should be evaluated...
  77. ncbi Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Med Virol 74:147-55. 2004
    ..The profile of circulating mediators may provide insights into the possible pathogenesis of particular clinical manifestations of this infection...
  78. ncbi Neutralization of human parvovirus B19 by plasma and intravenous immunoglobulins
    Jens Modrof
    Global Pathogen Safety and Plasma Control, Baxter BioScience, Vienna, Austria
    Transfusion 48:178-86. 2008
    b>Human parvovirus B19 (B19V) is a highly prevalent pathogen, and plasma pools for manufacturing of plasma-derived products have been shown to contain antibodies against B19V (B19V immunoglobulin G [IgG]).
  79. ncbi Human parvovirus B19 in young male patients with hemophilia A: associations with treatment product exposure and joint range-of-motion limitation
    J Michael Soucie
    Division of Hereditary Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30303, USA
    Transfusion 44:1179-85. 2004
    To evaluate the risk of human parvovirus B19 (B19) transmission in recombinant antihemophilic factor, the seroprevalence among 798 two- to seven-year-old boys with hemophilia was compared...
  80. pmc Interaction of parvovirus B19 with human erythrocytes alters virus structure and cell membrane integrity
    Claudia Bönsch
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    J Virol 82:11784-91. 2008
    ..On the other hand, the early exposure of VP1u might facilitate viral internalization and/or uncoating in target cells...
  81. pmc Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication
    Susan Wong
    Hematology Branch, NHLBI, NIH, Bldg 10 CRC, Rm 3E 5216, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 82:2470-6. 2008
    ..This is the first description of an ex vivo method to produce large numbers of EPCs that are highly permissive to B19V infection and replication, offering a cellular system that mimics in vivo infection with this pathogenic human virus...
  82. ncbi Unscrambling the role of human parvovirus B19 signaling in systemic autoimmunity
    Gregory J Tsay
    Department of Medicine and Institute of Immunology, Chung Shan Medical University, 110 Sec 1 Chien Kuo N Road, Taichung 402, Taiwan
    Biochem Pharmacol 72:1453-9. 2006
    ..Understanding the mechanisms used by B19 to alter the cell signaling machinery may provide further insight into the mechanism by which autoimmune diseases develop...
  83. doi Persistent infection by human parvovirus B19 in qualified blood donors
    Harumichi Matsukura
    Transfusion 48:1036-7. 2008
  84. ncbi Prospective evaluation of 618 pregnant women exposed to parvovirus B19: risks and symptoms
    J H Harger
    Magee Womens Hospital Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pennsylvania 15213 3180, USA
    Obstet Gynecol 91:413-20. 1998
    ..To assess the risk of maternal parvovirus B19 infection from exposure to various sources and the fetal morbidity of those infections...
  85. ncbi Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis
    G Pongratz
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    J Intern Med 266:296-301. 2009
    ..The described ELISPOT technique to detect virus-specific CD4+ T cells provides an excellent tool to analyse the state of parvovirus B19 infection for future studies to test this hypothesis...
  86. ncbi Role of parvovirus B19 infection in juvenile chronic arthritis. Is more investigation needed?
    F Angelini
    Clin Exp Rheumatol 21:684. 2003
  87. pmc Molecular characterization of human parvovirus B19 genotypes 2 and 3
    Zhaojun Chen
    Department of Clinical Laboratory, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China
    Virology 394:276-85. 2009
    ..Similar to the proapoptotic nature of the prototype B19V large non-structural protein (NS1), the A6 and V9 NS1 proteins also are potent inducers of apoptosis in B19V-permissive cells...
  88. ncbi Human parvovirus B19 infection and antiphospholipid antibodies
    Philipp von Landenberg
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Autoimmun Rev 6:278-85. 2007
    Erythema infectiosum is the main manifestation of human parvovirus B19 infections...
  89. pmc Biological and immunological relations among human parvovirus B19 genotypes 1 to 3
    Anna Ekman
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Virol 81:6927-35. 2007
    The human parvovirus B19 is now divided into three genotypes: type 1 (prototype), type 2 (A6- and LaLi-like), and type 3 (V9-like). In overall DNA sequence, the three virus types differ by approximately 10%...
  90. ncbi Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection
    Yasuhiko Munakata
    Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Blood 106:3449-56. 2005
    b>Human parvovirus B19 (B19) infects human erythroid cells expressing P antigen...
  91. ncbi Human parvovirus B19 serology and avidity using a combination of recombinant antigens enables a differentiated picture of the current state of infection
    K I Pfrepper
    MIKROGEN molekularbiologische Entwicklungs GmbH, Neuried, Germany
    J Vet Med B Infect Dis Vet Public Health 52:362-5. 2005
    ..For the recombinant line assay, five antigens of human parvovirus B19 that were recombinantly produced in Escherichia coli were applied directly on nitrocellulose membranes: VP2,..
  92. ncbi Human parvovirus B19 infection in children with new onset Type 1 diabetes mellitus
    T A O'Brayan
    Diabet Med 22:1778-9. 2005
  93. ncbi Intravenous immunoglobulins in autoimmune- or parvovirus B19-mediated pure red-cell aplasia
    Luc Mouthon
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hôpitaux de Paris and Université Paris V, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Autoimmun Rev 4:264-9. 2005
    ..as lymphoproliferative disorders), thymoma, autoimmune disorders, pregnancy, or as a consequence of chronic human parvovirus B19 (B19) infection in an immunologically incompetent host...
  94. pmc A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals
    V Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 80:6697-701. 2006
    ..1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design...
  95. ncbi Parvovirus B19 in an immunocompetent adult patient with acute liver failure: an underdiagnosed cause of acute non-A-E viral hepatitis
    J Kee Ho
    Department of Medicine, University of British Columbia, Vancouver
    Can J Gastroenterol 19:161-2. 2005
    ..Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure...
  96. ncbi Parvovirus B19 infection contributes to severe anemia in young children in Papua New Guinea
    James Wildig
    Department of Infectious Diseases and Immunology, University of Sydney, Sydney, Australia
    J Infect Dis 194:146-53. 2006
    ..We sought to determine whether infection with parvovirus B19 (B19), which causes the cessation of erythropoiesis for 3-7 days, might precipitate some cases of severe anemia...
  97. ncbi Recurrent high level parvovirus B19/genotype 2 viremia in a renal transplant recipient analyzed by real-time PCR for simultaneous detection of genotypes 1 to 3
    Lutz Liefeldt
    Department of Nephrology, School of Medicine, Charite, Schumannstr, Berlin, Germany
    J Med Virol 75:161-9. 2005
    ....
  98. ncbi Sensitive and rapid diagnosis of human parvovirus B19 infection by loop-mediated isothermal amplification
    Y Yamada
    First Department of Dermatology, School of Medicine, and Sakura Hospital, Toho University, Tokyo, Japan
    Br J Dermatol 155:50-5. 2006
    b>Human parvovirus B19 (B19) infections exhibit various skin manifestations that are similar to and hence hard to distinguish from many other skin diseases...
  99. pmc Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity
    Carlos Ros
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    J Virol 80:12017-24. 2006
    The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection...
  100. ncbi Human parvovirus B19 non-structural protein (NS1) induces apoptosis through mitochondria cell death pathway in COS-7 cells
    Tsai Ching Hsu
    Department of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Scand J Infect Dis 36:570-7. 2004
    b>Human parvovirus B19 has been found in various tissues in addition to erythroid lineage cells, and non-structural protein (NS1) is reported to induce cytotoxicity and apoptosis in erythroid lineage cells, but the mechanism in non-..
  101. ncbi The relationship between arthritis and human parvovirus B19 infection
    R Caliskan
    Microbiology and Clinical Microbiology Department, Cerrahpasa Medical Faculty, Istanbul University, P K 34303, Istanbul, Turkey
    Rheumatol Int 26:7-11. 2005
    In order to evaluate the role of human parvovirus B19 in the etiopathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), synovial fluid and blood specimens were collected at 1-month ..

Research Grants20

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..NIBSC), London, England, we demonstrated that SuperFluids(tm) CFI can inactivate more than 4 logs of human Parvovirus B19 (one of the smallest and toughest viruses) in human plasma in a two-stage CFI unit in less than 20 seconds...
  2. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human parvovirus B19 (B19V) infection causes hydrops fetalis in pregnant women during the second- trimester...
  3. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..London, England, we have also demonstrated that SuperFluids" CFI can inactivate more than 4 logs of human Parvovirus B19 in human serum in a two-stage CFI unit in less than one minute...
  4. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
    ..the mutant capsids will be examined and compared to wild type viruses; (5) Determine the high resolution structure of the human parvovirus B19 capsid and correlate that structure with the known properties of the virus.
  5. MODEL FOR EMERGENCE OF PARVOVIRUS B19 VIRULENCE
    STANLEY NAIDES; Fiscal Year: 1999
    b>Human parvovirus B19 causes well described clinical disease. The association of parvovirus B19 infection with well known but previously considered idiopathic disease qualifies B19 as an ~emerging~ pathogen...
  6. HUMAN PARVOVIRUS B19
    Arun Srivastava; Fiscal Year: 1992
    ..The long-term objectives of these studies are to unravel some of the intricacies of the cellular and molecular interactions of the B19 parvovirus with, and its remarkable specificity for, the hematopoietic cells of erythroid lineage...
  7. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS B19 IGG/M
    PAUL MARIE HONHON; Fiscal Year: 1990
    The Human Parvovirus B19 is the agent of several disease states: erythema contagiosum, a transient arthritis, and aplastic crisis in sickle cell anemia patients, and hydrops fetalis (a usually fatal outcome of pregnan- cy)...
  8. STRUCTURE/FUNCTION RELATIONS IN PARVOVIRUS CELL BINDING
    STANLEY NAIDES; Fiscal Year: 2000
    DESCRIPTION: Human parvovirus B19 causes a spectrum of clinical syndromes...
  9. RECEPTORS AND ENTRY PROCESS OF CANINE PARVOVIRUS
    SUKLA CHATTOPADHYAY; Fiscal Year: 1993
    ..These studies should provide important information on the early stages of parvovirus-host cell interaction...
  10. MECHANISM OF HEMATPOIETIC SUPPRESSION IN HIV-1 INFECTION
    Ronald Hoffman; Fiscal Year: 1993
    ..In addition, the effect of two other viral pathogens, cytomegalovirus (CMV) and the human parvovirus B19 (HPV-B19) on hematopoiesis in AIDS patients will also be examined...
  11. PERSISTENT AND PRENATAL PARVOVIRUS INFECTION
    Robert Jacoby; Fiscal Year: 2000
    ..Because the properties of RV infection to be studied resemble those of infection with human parvovirus B19, the research may contribute to understanding of persistent and prenatal human parvovirus infection by ..
  12. Human Parvovirus B19 Vectors: Mechanism of Transduction
    Arun Srivastava; Fiscal Year: 2008
    ..In contrast to AAV, which possesses a broad host-range, the pathogenic human parvovirus B19 has been shown to have a remarkably narrow tissue-tropism for erythroid progenitor cells presumably because ..
  13. Short Tandem Repeat Polymorphisms in Cytomegalovirus
    James Bale; Fiscal Year: 2003
    ..Characterizing HCM' strains by STR analysis will facilitate future studies of HCMV evolution and will provide a novel means t to fingerprint HCMV strains. ..
  14. The Cytoskeleton in HAART-Induced Cardiomyopathy
    David Nelson; Fiscal Year: 2006
    ..Specific Aim 2: Characterization of the cytoskeleton in HAART-treated transgenic mice. Specific Aim 3: Role of extrinsic stimuli in the development of HAART-induced cardiomyopathy. ..
  15. Risk of Blood Borne Transmission of CJD
    Shimian Zou; Fiscal Year: 2008
    ..Publishanddisseminateresultsof thestudy. ..
  16. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  17. PULMONARY COMPLICATIONS IN PEDIATRIC SICKLE CELL DISEASE
    Kim Smith Whitley; Fiscal Year: 2002
    ....
  18. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..