papillomaviridae

Summary

Summary: A family of small, non-enveloped DNA viruses infecting MAMMALS. There is one genus: PAPILLOMAVIRUS.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
  3. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
  4. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
  5. pmc The causal relation between human papillomavirus and cervical cancer
    F X Bosch
    Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Clin Pathol 55:244-65. 2002
  6. pmc Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry and Program of Public Health, University of California Irvine, Irvine, CA 92697, USA
    Virology 401:70-9. 2010
  7. ncbi Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
    Silvia de Sanjose
    IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    Lancet Oncol 11:1048-56. 2010
  8. ncbi Human papillomavirus oncoproteins: pathways to transformation
    Cary A Moody
    Department of MicrobiologyImmunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nat Rev Cancer 10:550-60. 2010
  9. ncbi Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings
    Laia Bruni
    Unit of Infections and Cancer, Cancer Epidemiology Research Program, IDIBELL Institut Català d Oncologia, Barcelona, Spain
    J Infect Dis 202:1789-99. 2010
  10. pmc Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis
    G M Clifford
    International Agency for Research on Cancer, 150, cours Albert Thomas, 69008 Lyon, France
    Br J Cancer 88:63-73. 2003

Research Grants

  1. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
  2. Natural History of CIN2 in Adolescents
    Anna Barbara Moscicki; Fiscal Year: 2007
  3. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
  4. MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATION
    Louise T Chow; Fiscal Year: 2013
  5. NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIA
    Anna Barbara Moscicki; Fiscal Year: 2004
  6. MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION
    Eduardo Franco; Fiscal Year: 2003
  7. Effect of Oxidant Load on HPV Persistence and CIN (SIL)
    Anna Giuliano; Fiscal Year: 2008
  8. HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)
    Cosette Marie Wheeler; Fiscal Year: 2010
  9. Human Papillovirus Testing in Adolescents
    Jessica Kahn; Fiscal Year: 2006
  10. Effect of Male Circumcision on Penile HPV Infection
    JENNIFER SUSAN SMITH; Fiscal Year: 2010

Detail Information

Publications311 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
    ..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
  3. ncbi The global health burden of infection-associated cancers in the year 2002
    Donald Maxwell Parkin
    Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
    Int J Cancer 118:3030-44. 2006
    ..The attributable fraction at the specific sites varies from 100% of cervix cancers attributable to the papilloma viruses to a tiny proportion (0.4%) of liver cancers (worldwide) caused by liver flukes...
  4. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
    ..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...
  5. pmc The causal relation between human papillomavirus and cervical cancer
    F X Bosch
    Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Clin Pathol 55:244-65. 2002
    ..It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented...
  6. pmc Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry and Program of Public Health, University of California Irvine, Irvine, CA 92697, USA
    Virology 401:70-9. 2010
    We present an expansion of the classification of the family Papillomaviridae, which now contains 29 genera formed by 189 papillomavirus (PV) types isolated from humans (120 types), non-human mammals, birds and reptiles (64, 3 and 2 types, ..
  7. ncbi Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
    Silvia de Sanjose
    IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    Lancet Oncol 11:1048-56. 2010
    ..We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer...
  8. ncbi Human papillomavirus oncoproteins: pathways to transformation
    Cary A Moody
    Department of MicrobiologyImmunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nat Rev Cancer 10:550-60. 2010
    ..Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis...
  9. ncbi Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings
    Laia Bruni
    Unit of Infections and Cancer, Cancer Epidemiology Research Program, IDIBELL Institut Català d Oncologia, Barcelona, Spain
    J Infect Dis 202:1789-99. 2010
    ..Baseline information on human papillomavirus (HPV) prevalence and type distribution is highly desirable to evaluate the impact of prophylactic HPV vaccines in the near future...
  10. pmc Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis
    G M Clifford
    International Agency for Research on Cancer, 150, cours Albert Thomas, 69008 Lyon, France
    Br J Cancer 88:63-73. 2003
    ..A majority of ICC was associated with HPV16 or 18 in all regions, but approximately a quarter of all ICC cases were associated with one of 16 other HPV types, their distribution varying by region...
  11. ncbi Papillomaviruses and cancer: from basic studies to clinical application
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nat Rev Cancer 2:342-50. 2002
    ..Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?..
  12. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  13. ncbi Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication
    Ni Li
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 128:927-35. 2011
    ..However, estimating the fraction of ICC attributable to different types is increasingly complicated by the detection of multiple HPV infections in ICC...
  14. ncbi Classification of papillomaviruses
    Ethel Michele de Villiers
    Reference Center for Papillomaviruses, Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Virology 324:17-27. 2004
    ..PVs are a taxonomic family of their own, Papillomaviridae, unrelated to the polyomaviruses...
  15. ncbi Human papillomavirus immortalization and transformation functions
    Karl Munger
    Department of Pathology, Harvard Medical School, Armenise Building 544, 200 Longwood Avenue, Boston, MA 02115 5701, USA
    Virus Res 89:213-28. 2002
    ..This paper will review the state of the field at the time of the 19th International Papillomavirus Workshop in September 2001 with respect to the HPV encoded oncoproteins...
  16. ncbi Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions
    Anna R Giuliano
    Risk Assessment, Detection and Intervention Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Vaccine 26:K17-28. 2008
    ....
  17. ncbi High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma
    Lisa Licitra
    Head and Neck Cancer Medical Oncology Unit, Medical Statistics and Biometry, Department of Head and Neck Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Clin Oncol 24:5630-6. 2006
    ..To which extent the viral integration by itself, and/or the associated wild-type (wt) TP53 status, and/or a functional p16 contribute to prognosis is unclear...
  18. ncbi Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study
    Rolando Herrero
    International Agency for Research on Cancer, Lyon, France rherrero amnet co cr
    J Natl Cancer Inst 95:1772-83. 2003
    ..To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries...
  19. ncbi Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?
    Anders Näsman
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 125:362-6. 2009
    ..In conclusion, the incidence of HPV-positive cancers is still increasing in the County of Stockholm, suggesting an epidemic of a virus-induced carcinoma, with soon practically all tonsillar SCC being HPV positive, as in cervical cancer...
  20. pmc EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
    ..To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer...
  21. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  22. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
    ..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
  23. pmc Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia
    Kate Cuschieri
    Specialist Virology Centre, Royal Infirmary of Edinburgh, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:2536-45. 2008
    ..Currently, there is promising data indicating that HPV mRNA and p16 might play an important role in future cervical cancer screening scenarios. Still, large randomized studies are necessary to confirm the preliminary data...
  24. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
    ..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
  25. pmc Using biomarkers as objective standards in the diagnosis of cervical biopsies
    Mary T Galgano
    Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 34:1077-87. 2010
    ..In conclusion, with a rigorous evaluation, we found immunohistochemical staining for p16 to be a useful and reliable diagnostic adjunct for distinguishing biopsies with and without CIN2(+)...
  26. ncbi The natural history of cervical HPV infection: unresolved issues
    Ciaran B J Woodman
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Cancer 7:11-22. 2007
    ..We discuss areas of uncertainty, and their possible effect on disease prevention strategies...
  27. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ....
  28. pmc Bead-based multiplex genotyping of human papillomaviruses
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 44:504-12. 2006
    ..922) but also indicated a higher sensitivity of MPG. In conclusion, MPG appears to be highly suitable for large-scale epidemiological studies and vaccination trials as well as for routine diagnostic purposes...
  29. ncbi The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
    J Natl Cancer Inst 97:1072-9. 2005
    ....
  30. pmc Papillomavirus genome structure, expression, and post-transcriptional regulation
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Front Biosci 11:2286-302. 2006
    ..Continuing research on post-transcriptional regulation of papillomavirus infection will remain as a future focus to provide more insights into papillomavirus-host interactions, the virus life-cycle, and viral oncogenesis...
  31. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 62:147-72. 2012
    ....
  32. ncbi Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract
    Nicolas Wentzensen
    Institute of Molecular Pathology, Department of Pathology, Heidelberg, Germany
    Cancer Res 64:3878-84. 2004
    ..No evidence for targeted disruption or functional alteration of critical cellular genes by the integrated viral sequences could be found...
  33. ncbi Current concepts on human papillomavirus infections in children
    Stina Syrjanen
    Department of Oral Pathology and Oral Radiology, Institute of Dentistry and MediCity Research Laboratory, University of Turku, Finland
    APMIS 118:494-509. 2010
    ..Early in life, infections by the high-risk HPV genotypes may also remain persistent for a considerable period, and should be of considerable importance for HPV vaccination strategies...
  34. ncbi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  35. ncbi Characterization of viral-cellular fusion transcripts in a large series of HPV16 and 18 positive anogenital lesions
    Nicolas Wentzensen
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Oncogene 21:419-26. 2002
    ..These data demonstrate that target directed insertional mutagenesis might occur in few HPV-induced anogenital lesions, however, it is rather the exception than the rule...
  36. ncbi The papillomavirus life cycle
    John Doorbar
    Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Clin Virol 32:S7-15. 2005
    ..As with other DNA tumour viruses, such abortive infections can predispose to cancer...
  37. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
    ..This new primer system will be useful in assessing the natural history of HPV infections, particularly when the analysis requires HPV typing...
  38. ncbi Against which human papillomavirus types shall we vaccinate and screen? The international perspective
    Nubia Munoz
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:278-85. 2004
    ..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
  39. ncbi Prevalence of HPV infection among men: A systematic review of the literature
    Eileen F Dunne
    Division of STD Prevention, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 194:1044-57. 2006
    ..2 million persons are newly infected every year in the United States. There are limited data on HPV infection in heterosexual men...
  40. ncbi Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia
    F Xavier Bosch
    Cancer Epidemiology Research Program CERP, Institut Català d Oncologia Catalan Institute of Oncology ICO, L Hospitalet de Llobregat Barcelona, Spain
    Vaccine 26:K1-16. 2008
    ....
  41. ncbi Human papillomavirus prevalence and type distribution in penile carcinoma
    C Miralles-Guri
    Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Program, Institut Catala d Oncologia, IDIBELL, L Hospitalet de Ll, Barcelona, Spain
    J Clin Pathol 62:870-8. 2009
    ..HPV prevalence in penile tumours is reported to be associated to a variety of morphological changes. Its determination will provide a better estimate for HPV related cancer burden and its preventable fraction...
  42. pmc Papillomavirus E6 proteins
    Heather L Howie
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Virology 384:324-34. 2009
    ....
  43. pmc Clinical validation of the cobas 4800 HPV test for cervical screening purposes
    D A M Heideman
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 49:3983-5. 2011
    ..Accordingly, the cobas 4800 HPV test can be considered clinically validated for cervical screening...
  44. ncbi Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control
    Tina Wiest
    Molekularbiologisches Labor, Universitäts Hals Nasen Ohrenklinik, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Oncogene 21:1510-7. 2002
    ..A causal role of HPV16 in head and neck cancer is defined by: E6/E7 expression, viral integration with an intact E6 gene, and perturbation of pRb cell cycle control. Mostly, the p53 gene is wild-type...
  45. ncbi Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
    M Pett
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 212:356-67. 2007
    ....
  46. ncbi Oral human papillomavirus in healthy individuals: a systematic review of the literature
    Aimee R Kreimer
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Sex Transm Dis 37:386-91. 2010
    ..HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable...
  47. pmc Efficient intracellular assembly of papillomaviral vectors
    Christopher B Buck
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
    J Virol 78:751-7. 2004
    ..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
  48. ncbi Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive women
    Howard D Strickler
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Natl Cancer Inst 95:1062-71. 2003
    ..To address this issue, we examined HPV test results from repeated study visits in the WIHS and from an independent study, the HIV Epidemiology Research Study (HERS)...
  49. ncbi Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China
    Fang Hui Zhao
    Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Lancet Oncol 11:1160-71. 2010
    ..The aims of our study were to assess whether HPV DNA testing could be applied to cervical-cancer screening programmes in China, as well as other similar developing countries...
  50. pmc Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer
    Rabia Faridi
    Division of Molecular Virology, National Centre of Excellence in Molecular Biology, University of the Punjab, 87 West Canal Bank Road Lahore 53700, Pakistan
    Virol J 8:269. 2011
    ..Awareness for various diagnostic procedures such as Pap smears screening prove to be an effective way in eradicating the oncogenic potential of HPV...
  51. ncbi An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) infection and aspects of treatment and prevention
    Torbjörn Ramqvist
    Department of Oncology Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 31:1515-9. 2011
    ..Finally, we suggest that the possibility to vaccinate against HPV-positive OSCC should be examined...
  52. ncbi Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
    K Munger
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 20:7888-98. 2001
    ..The transforming activities of E7 largely reflect this important function...
  53. ncbi Distribution of human papillomavirus types in the anogenital tract of females and males
    Luisa Barzon
    Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Padova, Italy
    J Med Virol 82:1424-30. 2010
    ..These results show that genital HPV infection involves numerous HPV types, which have similar distribution patterns in females and males and in different anogenital anatomical sites...
  54. ncbi Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma
    Martine Peter
    Department of Tumour Biology, Institut Curie, F 75248 Paris, France
    J Pathol 221:320-30. 2010
    ..Structural alterations of the host genome are frequently observed at the integration site of HPV DNA in cervical cancer and may act in oncogenesis...
  55. pmc Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women
    Anna Barbara Moscicki
    Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Obstet Gynecol 116:1373-80. 2010
    ..To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression...
  56. pmc External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents
    Eftyhia Vardas
    Division of Medical Virology, University of Stellenbosch, South Africa and Lancet Laboratories, Johannesburg, South Africa
    J Infect Dis 203:58-65. 2011
    ..We examined the baseline prevalence of penile, scrotal, and perineal/perianal human papillomavirus (HPV) in heterosexual men (HM). We also evaluated baseline characteristics of HM to assess factors associated with prevalent HPV detection...
  57. ncbi Partitioning viral genomes in mitosis: same idea, different targets
    Alison A McBride
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0455, USA
    Cell Cycle 5:1499-502. 2006
    ..This mechanism has been best studied for bovine papillomavirus type 1. Recent evidence indicates that while this is a common strategy among papillomaviruses, different viruses have selected different chromosomal targets...
  58. pmc Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men
    Stephen Goldstone
    Mount Sinai School of Medicine, New York, New York 10011, USA
    J Infect Dis 203:66-74. 2011
    ..We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM)...
  59. ncbi Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men
    Bethany A Weaver
    Center for AIDS and STD Research, Department of Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359931, Seattle, WA 98104 USA
    J Infect Dis 189:677-85. 2004
    ..The HPV prevalence was similar for circumcised and uncircumcised men. Testing multiple sites increased the number of men for whom HPV DNA was detected...
  60. pmc Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay
    David Opalka
    Virus and Cell Biology, Merck Research Laboratories, Wayne, Pennsylvania 19087 8630, USA
    Clin Diagn Lab Immunol 10:108-15. 2003
    ....
  61. ncbi Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    J Infect Dis 189:686-98. 2004
    ..8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection...
  62. ncbi Common fragile sites are preferential targets for HPV16 integrations in cervical tumors
    Erik C Thorland
    Department of Biochemistry and Molecular Biology Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:1225-37. 2003
    ..2), and FRA17B (17q23). Finally, our data suggest that cellular genes, such as Notch 1, are disrupted by the HPV16 integrations, which may contribute to the malignant phenotype...
  63. ncbi Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
    Elaine M Smith
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Int J Cancer 108:766-72. 2004
    ..An exfoliated oral cytology test for HPV was a significant predictor of HR types in the cancers, suggesting that an oral rinse may provide an early biomarker of infected tumors...
  64. ncbi Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas
    Harriet C Hafkamp
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Cancer 122:2656-64. 2008
    ..These findings indicate that oncogenic processes in the tonsils of non-smokers differ from those occurring in smokers, the former being related to HPV 16 infection...
  65. pmc The human papillomavirus E7 oncoprotein
    Margaret E McLaughlin-Drubin
    Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Virology 384:335-44. 2009
    ..This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability...
  66. ncbi Human papillomavirus variants and squamous neoplasia of the cervix
    A Giannoudis
    Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    J Pathol 193:295-302. 2001
    ..This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice...
  67. ncbi Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners
    Xavier Castellsague
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Hospitalet de Llobregat, Barcelona, Spain
    N Engl J Med 346:1105-12. 2002
    ..It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner...
  68. pmc Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women
    Howard Minkoff
    Department of Obstetrics and Gynecology, Maimonides Medical Center and State University of New York Downstate, Brooklyn, NY 11219, USA
    J Infect Dis 201:681-90. 2010
    ..Prior studies, however, did not consider patients' adherence to their regimens or HAART effectiveness (viral suppression)...
  69. ncbi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  70. ncbi Papillomaviruses in the causation of human cancers - a brief historical account
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Virology 384:260-5. 2009
    ..This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments...
  71. pmc Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysis
    Beibei Lu
    Risk Assessment, Detection and Intervention Program, H, Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    BMC Infect Dis 11:13. 2011
    ..We conducted a systematic review and meta-analysis to assess efficacy and safety of prophylactic HPV vaccines against cervical cancer precursor events in women...
  72. pmc Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation
    Cary A Moody
    Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Pathog 5:e1000605. 2009
    ..These findings identify a major regulatory mechanism responsible for productive HPV replication in differentiating cells. Our results have potential implications for the development of anti-viral therapies to treat HPV infections...
  73. ncbi The epidemiology of genital human papillomavirus infection
    Helen Trottier
    Department of Oncology, McGill University, Montreal, Canada
    Vaccine 24:S1-15. 2006
    ..This shift in research focus coincides with a shift in cancer prevention techniques towards immunization with HPV vaccines and HPV testing of precancerous lesions...
  74. ncbi Prevailing papillomavirus types in non-melanoma carcinomas of the skin in renal allograft recipients
    E M de Villiers
    Division of Tumour Virus Characterization, Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 73:356-61. 1997
    ..The EV group of HPVs predominate in the cancers, but the multiplicity of HPV types detected with double infection in some lesions suggests virus/virus in addition to virus/host interaction in the carcinogenic process...
  75. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  76. ncbi Human papillomavirus prevalence and type distribution in male anogenital sites and semen
    Carrie M Nielson
    Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA
    Cancer Epidemiol Biomarkers Prev 16:1107-14. 2007
    ..Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized...
  77. pmc Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4
    David Gagnon
    Laboratory of Molecular Virology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    J Virol 83:4127-39. 2009
    ..These results indicate that the stability of E2 is increased upon complex formation with Brd4 and highlight the value of the luciferase assay for the study of E2 degradation...
  78. pmc Global proficiency study of human papillomavirus genotyping
    Carina Eklund
    WHO HPV LabNet Global Reference Laboratory, Department of Clinical and Medical Microbiology, Laboratory Medicine Skåne, Lund University, Malmo, Sweden
    J Clin Microbiol 48:4147-55. 2010
    ....
  79. pmc Circumcision and human papillomavirus infection in men: a site-specific comparison
    B Y Hernandez
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    J Infect Dis 197:787-94. 2008
    ..Lack of circumcision has been identified as a risk factor for male genital human papillomavirus (HPV) infection, although this association has not been consistently supported...
  80. ncbi Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women
    D Heather Watts
    National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892 7510, USA
    J Infect Dis 191:1129-39. 2005
    ..Whether the natural history of human papillomavirus (HPV) infection is affected by bacterial vaginosis (BV) or Trichomonas vaginalis (TV) infection has not been adequately investigated in prospective studies...
  81. ncbi Genome variation of human papillomavirus types: phylogenetic and medical implications
    Hans Ulrich Bernard
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Int J Cancer 118:1071-6. 2006
    ....
  82. ncbi Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea
    Hai Rim Shin
    Research Institute, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
    J Infect Dis 190:468-76. 2004
    ..Little is known about the prevalence of human papillomavirus (HPV) infection in young adults in Asia...
  83. ncbi Human papillomavirus type 16 DNA sequence
    K Seedorf
    Virology 145:181-5. 1985
    ..The sequence reveals an interruption of the reading frame coding for a suspected E1 protein...
  84. pmc Identification of human papillomavirus DNA gene sequences in human breast cancer
    C Y Kan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Br J Cancer 93:946-8. 2005
    ..Human papilloma viruses may have a role in human breast cancer. We speculate that HPVs may be transmitted by hand from the female perineum to the breast...
  85. ncbi Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Clin Oncol 27:1992-8. 2009
    ....
  86. pmc Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
    Kyung Won Huh
    The Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:11492-7. 2005
    ..Therefore, p600 is a cellular target of E7 that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation...
  87. pmc The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses
    A Antonsson
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Virol 74:11636-41. 2000
    ..These results demonstrate that normal human skin harbors an array of papillomaviruses, most of them previously unknown...
  88. pmc Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7
    N R Chu
    StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Exp Immunol 121:216-25. 2000
    ..These studies extend previous observations on the induction of cytotoxic T lymphocytes by hsp fusion proteins and are consistent with the clinical application of hspE7 as an immunotherapy for human cervical and anal dysplasia and cancer...
  89. ncbi Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins
    Mako Narisawa-Saito
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 98:1505-11. 2007
    ..In the present article, the mechanisms of HPV16 E6- and E7-induced multistep carcinogenesis and recently identified functions of these onco-proteins are reviewed...
  90. ncbi Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer
    Gary M Clifford
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005
    ..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
  91. pmc Detection of multiple human papillomavirus types in Condylomata acuminata lesions from otherwise healthy and immunosuppressed patients
    D R Brown
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5124, USA
    J Clin Microbiol 37:3316-22. 1999
    ..Further studies are needed to determine the influence these additional HPV types have on the epidemiology of genital tract HPV infections and the natural history of condylomata acuminata, especially in immunosuppressed patients...
  92. ncbi 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 197:346-55. 2007
    ..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
  93. pmc Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso
    M N Didelot-Rousseau
    Department of Virology, Montpellier University Hospital, 34295 Montpellier, France
    Br J Cancer 95:355-62. 2006
    ..1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine...
  94. ncbi Human papillomavirus in oral exfoliated cells and risk of head and neck cancer
    Elaine M Smith
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City 52242, USA
    J Natl Cancer Inst 96:449-55. 2004
    ....
  95. ncbi Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers
    Soenke Jan Weissenborn
    Institute of Virology, University of Cologne, Koeln, Germany
    J Invest Dermatol 125:93-7. 2005
    ..Although a passenger state cannot be excluded, the data are compatible with a carcinogenic role of HPV in early steps of tumor development...
  96. ncbi Triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the HPV test positivity rate
    Marc Arbyn
    Scientific Institute of Public Health, Brussels, Belgium
    J Cell Mol Med 13:648-59. 2009
    ..Research is needed to identify more specific methods to triage women with low-grade squamous cervical lesions...
  97. pmc Evaluation of different techniques for identification of human papillomavirus types of low prevalence
    Ivan Sabol
    Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, P O Box 180, Zagreb HR 10002, Croatia
    J Clin Microbiol 46:1606-13. 2008
    ..Therefore, a universally evaluated and agreed upon HPV typing assay or a combination of current assays is needed for possible clinical applications, and knowledge of their limitations is advised...
  98. ncbi Incident high-grade squamous intraepithelial lesions in Senegalese women with and without human immunodeficiency virus type 1 (HIV-1) and HIV-2
    Stephen E Hawes
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Natl Cancer Inst 98:100-9. 2006
    ..We assessed the relationships among human papillomavirus (HPV) types and persistence, HIV-1 and/or HIV-2 infection, and the development of high-grade cervical squamous intraepithelial lesions (HSILs) in a prospective study...
  99. ncbi Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer
    Marie Helene Mayrand
    Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
    N Engl J Med 357:1579-88. 2007
    ..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
  100. ncbi HPV detection rate in saliva may depend on the immune system efficiency
    Maria Adamopoulou
    Department of Maxillofacial Surgery, University of Athens Medical School, Athens, Greece
    In Vivo 22:599-602. 2008
    ....
  101. ncbi The regulation of cell proliferation by the papillomavirus early proteins
    N Abdul Hamid
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Cell Mol Life Sci 66:1700-17. 2009
    ..Here we outline evidence that suggests a role for E2 in the regulation of cell proliferation, and we discuss the importance of this regulation in viral infection and cervical tumourigenesis...

Research Grants68

  1. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
    ..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. [unreadable] [unreadable] [unreadable]..
  2. Natural History of CIN2 in Adolescents
    Anna Barbara Moscicki; Fiscal Year: 2007
    ..S. and specifically assess how best to modify cytology-based screening, utilize HPV diagnostics, and tailor aoDrooriate follow-uo strategies for adolescents and vouna women diaanosed with CIN 2 ..
  3. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
    ..N&N proposes to develop N-MCT as a therapeutic against the Herpesviridae, Papillomaviridae and Poxviridae genera of Class I dsDNA viruses, which include HSV-1, HSV-2, HSV-8, VZV, EBV, smallpox, ..
  4. MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATION
    Louise T Chow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human papillomaviridae comprise a large family of DNA viruses tropic for mucosal or cutaneous epithelium...
  5. NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIA
    Anna Barbara Moscicki; Fiscal Year: 2004
    ..The understanding of both local and systemic immune responses to initial and subsequent HPV infections may be key in vaccine or therapeutic developments. ..
  6. MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION
    Eduardo Franco; Fiscal Year: 2003
    ..abstract_text> ..
  7. Effect of Oxidant Load on HPV Persistence and CIN (SIL)
    Anna Giuliano; Fiscal Year: 2008
    ..abstract_text> ..
  8. HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)
    Cosette Marie Wheeler; Fiscal Year: 2010
    ..Image-based diagnostic standards will be critical to future population evaluations. ..
  9. Human Papillovirus Testing in Adolescents
    Jessica Kahn; Fiscal Year: 2006
    ..Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls. ..
  10. Effect of Male Circumcision on Penile HPV Infection
    JENNIFER SUSAN SMITH; Fiscal Year: 2010
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  11. COGNITIVE AND EMOTIONAL RESPONSES TO AN HPV DIAGNOSIS IN MEN
    Ellen M Daley; Fiscal Year: 2010
    ..These data will assist in the planning, implementation, and evaluation of interventions to reduce HPV infection in both sexes. ..
  12. CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16
    Mayumi Nakagawa; Fiscal Year: 2002
    ....
  13. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Control of Human Papillomavirus-16 Transcription
    Hans Ulrich Bernard; Fiscal Year: 2006
    ....
  15. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
    ..abstract_text> ..
  16. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
    ..abstract_text> ..
  17. Planning Grant for a Study of the Effect of Radiation o*
    Camille Ragin; Fiscal Year: 2006
    ....
  18. FUNCTIONAL ANALYSIS OF THE E6AP UBIQUITIN PROTEIN LIGASE
    Peter Howley; Fiscal Year: 2007
    ..unreadable]..
  19. The Roles of IRF-3 in the Cellular Response to Viral Infection
    Peter Howley; Fiscal Year: 2007
    ..We will explore this pathway and examine the mechanisms by which some viruses inactivate this pathway for the replication of the virus and the survival of the infected cell. ..
  20. Interventions to Increase HBV Vaccination in STD Clinics
    Gregory Zimet; Fiscal Year: 2006
    ..The relationships of the interventions, socio-demographics, attitudes and behaviors to the outcome measures will be assessed with multiple logistic regression (MLR) and path analysis via structural equation modeling. ..
  21. HERPES SIMPLEX VIRUS IN THE TREATMENT OF ORAL CANCER
    EDWARD SHILLITOE; Fiscal Year: 2004
    ..abstract_text> ..
  22. HIV Testing and Women's Attitudes on HIV Vaccine Trials
    Gregory D Zimet; Fiscal Year: 2010
    ..abstract_text> ..
  23. Cidofovir for Perianal Dysplasia in HIV Patients
    Elizabeth Stier; Fiscal Year: 2006
    ..Novel treatments, such as topical cidofovir, may prevent pre-cancerous lesions from developing into cancer in HIV-infected patients. ..
  24. NATURAL HISTORY OF ANAL NEOPLASIA IN HIV INFECTED MEN
    Joel Palefsky; Fiscal Year: 2002
    ....
  25. HPV Induced Pathogenesis in Head and Neck Cancer
    NICOLAS SCHLECHT; Fiscal Year: 2006
    ..abstract_text> ..
  26. DIET AND DURATION OF CERVICAL HPV INFECTION
    MARC GOODMAN; Fiscal Year: 2009
    ....
  27. MECHANISM OF HPV E2 MEDIATED CELLULAR GROWTH SUPPRESSION
    Peter Howley; Fiscal Year: 2002
    ..In this grant application, we propose to examine the mechanisms by which E2 causes cellular growth suppression. ..
  28. Study of genomic instability caused by HPV16 E6 and E7
    Dennis McCance; Fiscal Year: 2008
    ..abstract_text> ..
  29. EFFECT OF HPV-16 E7 ON DIFFERENTIATING EPITHELIAL CELLS
    Dennis McCance; Fiscal Year: 2005
    ..Additionally, we will investigate the ability of E7 to increase cyclin/kinase activity in differentiating cells, which also contain high levels of kinase inhibitors. ..
  30. Mechanisms of HPV DNA Segregation
    LOUISE CHOW; Fiscal Year: 2008
    ..The anticipated outcome is a clear definition of the mechanisms of extrachromosomal plasmid segregation and maintenance. [unreadable] [unreadable] [unreadable]..
  31. Afro-Caribbean Consortium on viral and environmental risk factors for cancer
    Camille Ragin; Fiscal Year: 2007
    ..We have already had commitments from several investigators who are interested in participating in this Consortium. In total we estimate approximately 60-100 attendees. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Anal HPV Infection and ASIL in HIV+ and HIV- Women
    Joel Palefsky; Fiscal Year: 2006
    ..Knowledge of genes involved in ASIL pathogenesis may provide new approaches to therapy of both anal and cervical HSIL as well as markers for disease progression. ..
  33. CO-ACTIVATOR FUNCTION IN ORAL CANCER CELLS
    Dennis McCance; Fiscal Year: 2004
    ..Known targets of CBP/p300, whose function has been implicated in keratinocyte differentiation will be studied, and novel targets of CBP/p300 will be identified. ..
  34. Hepatitis C VIrus NS3 Helicase Inhibitor Discovery
    David Frick; Fiscal Year: 2008
    ..The goal here is to find chemicals that prevent the virus from replicating in human cells. [unreadable] [unreadable] [unreadable]..
  35. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
    ..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. [unreadable] [unreadable] [unreadable]..
  36. OVERCOMING CELLULAR SENESCENCE IN HUMAN EPITHELIAL CELLS
    Aloysius Klingelhutz; Fiscal Year: 2004
    ..These studies should have the potential of leading to new and innovative strategies for the prevention, diagnosis and treatment of human cancer. ..
  37. HIV Protective Immunity and Perinatal Exposure
    Louise Kuhn; Fiscal Year: 2006
    ..abstract_text> ..
  38. TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESS
    Joy Melnikow; Fiscal Year: 2002
    ..abstract_text> ..
  39. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2006
    ..It is expected that Dr. Monk will have obtained extramural funding for both his laboratory and clinical studies by the end of the period of support requested. ..
  40. Ureaplasmas in acute and persistent urethritis: clinical implications
    Lisa E Manhart; Fiscal Year: 2010
    ..The results of this study may lead to the identification of an additional cause of this syndrome, provide guidance on treatment decisions, and shed light on the etiology of persistent and recurrent cases. ..
  41. THE ROLE OF A NOVEL GAP IN EPITHELIAL ONCOGENESIS
    Vimla Band; Fiscal Year: 2003
    ..abstract_text> ..
  42. A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli
    Zhengrong Cui; Fiscal Year: 2008
    ..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. [unreadable] [unreadable] [unreadable]..
  43. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  44. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2009
    ....
  45. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce T Shiramizu; Fiscal Year: 2010
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  46. Characterization of the 11q13 Amplicon in Oral Cancer
    Susanne Gollin; Fiscal Year: 2006
    ..The results of this study may lead to targeted methods for prevention, early detection, therapy, and/or eradication of cells harboring gene amplification. ..
  47. Hepatitis B ESL Education for Chinese
    Victoria Taylor; Fiscal Year: 2009
    ..Our primary outcome will be HBV serologic testing. Knowledge about key hepatitis B facts will be examined as a secondary outcome. ..
  48. Role of Wnt signaling in Cervical Cancer Pathogenesis
    Aykut Uren; Fiscal Year: 2010
    ..Aykut The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  49. Translating an Efficaious HPV Vaccine into the Control of Cervical Cancer
    Sharon Bond; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. Molecular Profiling of Premalignant Oral Lesions
    Mark Lingen; Fiscal Year: 2008
    ..This molecular analysis may also greatly improve diagnostic prediction compared to the cellular pattern recognition currently used by pathologists. [unreadable] [unreadable]..
  51. The Mechanisms of Human Papillomavirus Pathogenicity
    Ann Roman; Fiscal Year: 2006
    ..By conducting these experiments under physiological conditions that mimic a natural infection, we expect to make novel contributions on the activities of this important protein. ..
  52. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  53. Depsipeptide for the Treatment of Head and Neck Cancer
    Missak Haigentz; Fiscal Year: 2006
    ..abstract_text> ..
  54. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
    ..The long-term goal of this research is to contribute to the development of a novel cost-effective radionuclide therapy for treatment of breast cancer and, possibly, for other NIS-expressing cancers such as thyroid cancer. ..
  55. Liver Cancer Control Among North American Chinese
    Victoria Taylor; Fiscal Year: 2006
    ..If effective, our outreach intervention could be used by health care facilities and community organizations serving less acculturated Chinese in North America. ..
  56. Molecular Interactions in Signaling and Vesicle Sorting
    JAMES BALEJA; Fiscal Year: 2007
    ..These investigations on the EH domain:NPF interaction are also expected to advance the application of NMR in understanding molecular recognition. ..
  57. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
  58. Cervical Cancer Control in Vietnamese Women
    Victoria Taylor; Fiscal Year: 2007
    ..abstract_text> ..
  59. HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERS
    Keerti Shah; Fiscal Year: 2004
    ..If HPV etiology is established for a subset of HNSCC, patients with these tumors may benefit from HPV-specific immunotherapies which are being evaluated for the treatment of invasive cervical cancer. ..
  60. EPIDEMIOLOGY OF ORAL HIV 1 & 2 INFECTION IN HIGH RISK WO
    Stephen Hawes; Fiscal Year: 2003
    ....
  61. Chlamydia trachomatis and Cervical Cancer
    MARGARET MADELEINE; Fiscal Year: 2003
    ..trachomatis may become a higher public health priority. Furthermore, our results would help determine whether further follow up of the C. trachomatis and cervical cancer association is warranted in a more expensive, prospective setting. ..
  62. Screening for STDs using home sampling in Estonia
    Anneli Uuskula; Fiscal Year: 2007
    ..This information will allow us to identify STD infected individuals, and to develop selective screening criteria to be used in general population studies and screening programs in Estonia. ..
  63. Functional Analysis of the VHL Tumor Suppressor Gene
    Robert Burk; Fiscal Year: 2006
    ....
  64. STDS, FERTILITY, MARRIAGE AND DEMOGRAPHIC PROJECTION
    Ronald Gray; Fiscal Year: 2002
    ..In collaboration with the U.S. Bureau of Census, data from the proposed study will be used to revise demographic projections of the effects of HIV on population growth, composition and AIDS orphanhood. ..
  65. HPV Testing--Self-Collected Samples for Cervical Cancer
    Laura Koutsky; Fiscal Year: 2003
    ....
  66. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  67. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2009
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..