human herpesvirus 8

Summary

Summary: A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.

Top Publications

  1. pmc Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    Xuezhong Cai
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:5570-5. 2005
  2. ncbi Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression
    Jeffrey Vieira
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109 8070, USA
    Virology 325:225-40. 2004
  3. ncbi Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT
    Johnan A R Kaleeba
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Science 311:1921-4. 2006
  4. pmc Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology, and Shands Cancer Center, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:12836-45. 2007
  5. pmc Identification of cellular genes targeted by KSHV-encoded microRNAs
    Mark A Samols
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, United States of America
    PLoS Pathog 3:e65. 2007
  6. pmc Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 604 Parran Hall, 130 De Soto St, Pittsburgh, PA 15261, USA
    J Virol 82:4793-806. 2008
  7. pmc Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest
    Matthias Ottinger
    Institut fur Virologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 80:10772-86. 2006
  8. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
  9. ncbi Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins
    P M Chaudhary
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75235 8593, USA
    Oncogene 18:5738-46. 1999
  10. ncbi Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection
    Pramod P Naranatt
    Department of Microbiology, Molecular Genetics and Immunology, Bioinformatics Core, and Microarray Core, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Cancer Res 64:72-84. 2004

Research Grants

  1. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
  2. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
  3. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
  4. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
  6. KSHV Lytic DNA Replication and its Control Mechanism
    Subhash C Verma; Fiscal Year: 2013
  7. Human Herpesvirus-8 Replication and Kaposi Sarcoma Response to Treatment
    Warren Phipps; Fiscal Year: 2013
  8. KSHV-Ori-Lyt-Dependent DNA Replication
    Yan Yuan; Fiscal Year: 2012
  9. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
  10. Rhesus HHV-8 homologue in AIDS-related malignancies
    Scott W Wong; Fiscal Year: 2013

Detail Information

Publications291 found, 100 shown here

  1. pmc Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    Xuezhong Cai
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:5570-5. 2005
    ..We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis...
  2. ncbi Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression
    Jeffrey Vieira
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109 8070, USA
    Virology 325:225-40. 2004
    ..This work also demonstrated strong synergy between KSHV/RTA and butyrate for the activation of KSHV lytic replication and the production of infectious virus...
  3. ncbi Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT
    Johnan A R Kaleeba
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Science 311:1921-4. 2006
    Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus 8) is the causative agent of Kaposi's sarcoma and other lymphoproliferative syndromes often associated with HIV/AIDS...
  4. pmc Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology, and Shands Cancer Center, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:12836-45. 2007
    ..Together, these findings indicate that KSHV miR-K12-11 is an ortholog of miR-155...
  5. pmc Identification of cellular genes targeted by KSHV-encoded microRNAs
    Mark A Samols
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, United States of America
    PLoS Pathog 3:e65. 2007
    ..These data suggest that KSHV-encoded miRNAs may contribute directly to pathogenesis by down-regulation of THBS1, a major regulator of cell adhesion, migration, and angiogenesis...
  6. pmc Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 604 Parran Hall, 130 De Soto St, Pittsburgh, PA 15261, USA
    J Virol 82:4793-806. 2008
    b>Human herpesvirus 8 (HHV-8) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease...
  7. pmc Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest
    Matthias Ottinger
    Institut fur Virologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 80:10772-86. 2006
    ..J. Barbera, J. V. Chodaparambil, B. Kelley-Clarke, V. Joukov, J. C. Walter, K. Luger, and K. M. Kaye, Science 311:856-861, 2006) of the LANA-1 N terminus with histones H2A and H2B...
  8. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    ....
  9. ncbi Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins
    P M Chaudhary
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75235 8593, USA
    Oncogene 18:5738-46. 1999
    ..Modulation of the NF-kappaB pathway may play a role in the natural history of infection by these viruses...
  10. ncbi Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection
    Pramod P Naranatt
    Department of Microbiology, Molecular Genetics and Immunology, Bioinformatics Core, and Microarray Core, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Cancer Res 64:72-84. 2004
    ....
  11. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangements
    Neelam Sharma-Walia
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Virol 78:4207-23. 2004
    b>Human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) envelope glycoprotein gB possesses an RGD motif, interacts with alpha 3 beta 1 integrin, and uses it as one of the entry receptors...
  12. ncbi KSHV vFLIP binds to IKK-gamma to activate IKK
    Nigel Field
    Department of Immunology and Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland St, London W1T 2AH, UK
    J Cell Sci 116:3721-8. 2003
    ..An inhibitor of Hsp90, geldanamycin, inhibited IKK's kinase activity induced by vFLIP and killed PEL cells, suggesting that vFLIP activation of IKK contributes to PEL cell survival...
  13. pmc Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR
    Farnaz D Fakhari
    Department of Microbiology and Immunology, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Virol 76:6213-23. 2002
    ..In the case of Kaposi's sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8), latent genes have been implicated in cell autonomous transformation, while certain lytic genes procure a ..
  14. pmc CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral
    Shizhen Emily Wang
    Molecular Virology Laboratories, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    J Virol 77:9590-612. 2003
    ....
  15. pmc ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection
    Neelam Sharma-Walia
    Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:10308-29. 2005
    ....
  16. pmc Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway
    Ke Lan
    Department of Microbiology and the Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:3468-78. 2005
    ..Our study describes a novel mechanism through which LANA maintains KSHV latency by targeting a major downstream effector of the Notch signaling pathway...
  17. ncbi Antibodies against human herpesvirus 8 in black South African patients with cancer
    F Sitas
    National Cancer Registry, Department of Anatomical Pathology, South African Institute for Medical Research, Johannesburg
    N Engl J Med 340:1863-71. 1999
    Infection with human herpesvirus 8 (HHV-8) has been consistently linked to Kaposi's sarcoma, but its mode of transmission, association with other cancers, and interaction with the human immunodeficiency virus type 1 (HIV-1) are largely ..
  18. ncbi The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex
    Li Liu
    Hamon Center for Therapeutic Oncology Research and Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Biol Chem 277:13745-51. 2002
    The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in immunocompromised individuals...
  19. pmc Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator
    Hiroyuki Nakamura
    Department of Microbiology and Molecular Genetics, Division of Tumor Virology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Virol 77:4205-20. 2003
    ..Thus, our streamlined gene expression system provides a novel means not only to study the effects of viral gene products on overall KSHV gene expression and replication, but also to understand the natural viral reactivation process...
  20. pmc The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway
    Yuying Liang
    Howard Hughes Medical Institute and Departments of Microbiology and Medicine, University of California, San Francisco, California 94143 0414, USA
    Genes Dev 16:1977-89. 2002
    ..These results indicate that KSHV has evolved a ligand-independent mechanism for constitutive activation of the Notch pathway as a part of its strategy for reactivation from latency...
  21. pmc The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
    Jianhong Hu
    Division of Hematology Oncology and Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 76:11677-87. 2002
    ..This notion is further strengthened by the unique modular structure of the KSHV TR element...
  22. ncbi KSHV infection and the pathogenesis of Kaposi's sarcoma
    Don Ganem
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:273-96. 2006
    ..evidence has accumulated correlating infection with this KS-associated herpesvirus (KSHV, also known as human herpesvirus 8) with the development of the disease...
  23. pmc Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity
    Mair Thomas
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:1656-61. 2008
    ..The down-regulation of ligands for both the NKG2D and NKp80 activation pathways provides KSHV with a powerful mechanism for evasion of NK cell antiviral functions...
  24. pmc Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis
    Fu Chun Zhou
    Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Virol 76:6185-96. 2002
    ..The feasibility of the system was illustrated through the generation of a KSHV mutant with the vIRF gene deleted. This cellular model is useful for the investigation of KSHV infection and pathogenesis...
  25. pmc Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction
    Yeon J Lee
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 7:e1000107. 2009
    ..SOX-induced mRNA turnover therefore represents both a novel mechanism of host shutoff as well as a new model system to probe the regulation of poly(A) tail-stimulated mRNA turnover in mammalian cells...
  26. pmc Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element binding proteins
    Huaxin Si
    Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Virol 80:9017-30. 2006
    ..This study will facilitate the generation and testing of new hypotheses to further our understanding of the mechanisms involved in KSHV persistence and its associated pathogenesis...
  27. pmc A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication
    Yiyang Xu
    Department of Microbiology, School of Medicine, Howard Bldg, University of Nevada Reno, Reno, NV 89557, USA
    J Virol 79:3479-87. 2005
    ..1 expression was not detected in TPA-induced BAC36Delta50-containing cells. These results showed that K-Rta is essential for lytic viral reactivation and transactivation of viral genes contributing to DNA replication...
  28. pmc Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus
    J Vieira
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 75:1378-86. 2001
    ..These data demonstrate that HCMV can activate KSHV lytic replication and suggest that HCMV could influence KSHV pathogenesis...
  29. ncbi Viral IL-6-induced cell proliferation and immune evasion of interferon activity
    Malini Chatterjee
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Science 298:1432-5. 2002
    ..Viral IL-6 bypasses the gp80 regulatory checkpoint by binding directly to the gp130 transducer molecule, resulting in tumor cell autocrine dependence on the viral cytokine for proliferation and survival...
  30. pmc Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs
    Joseph M Ziegelbauer
    Howard Hughes Medical Institute, GW Hooper Foundation, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 41:130-4. 2009
    ..Our results support that this type of expression profiling provides a potentially general approach to the identification of miRNA targets...
  31. ncbi Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy
    M Corbellino
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, Italy
    Blood 98:3473-5. 2001
    ..Rituximab should be added to the therapeutic armamentarium for KSHV-related MCD...
  32. pmc Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6
    Daming Chen
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Virol 83:722-33. 2009
    b>Human herpesvirus 8 (HHV-8)-encoded viral interleukin-6 (vIL-6) has been implicated as a key factor in virus-associated neoplasia because of its proproliferative and survival effects and also in view of its angiogenic properties...
  33. ncbi DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Immunol 176:1741-9. 2006
    b>Human herpesvirus 8 (HHV-8) causes Kaposi's sarcoma and pleural effusion lymphoma...
  34. ncbi Human gammaherpesvirus cytokines and chemokine receptors
    John Nicholas
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Interferon Cytokine Res 25:373-83. 2005
    ..Cytokines and chemokine receptors specified by the two human gammaherpesviruses, human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV), are the subject of this review...
  35. pmc Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
    Richard G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 100:10399-404. 2003
    ..Similar to malignant plasma cells, all PEL samples tested express the vitamin D receptor and are sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol)...
  36. ncbi The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation
    Yanxing Yu
    Molecular Virology Laboratories, Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 2123, USA
    Immunity 22:59-70. 2005
    ..Therefore, manipulation of the stability and function of IRF7 by the KSHV RTA transcription factor provides an unexpected regulatory strategy for circumventing the innate immune defence system...
  37. ncbi The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA
    Andrew J Barbera
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 311:856-61. 2006
    ..Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency...
  38. pmc KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA
    Fang Cheng
    Genome Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    PLoS Pathog 5:e1000324. 2009
    ....
  39. ncbi Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome
    Andrew J Barbera
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cell Cycle 5:1048-52. 2006
    ..Our data offer further insight into the mechanism of KSHV latency, and also reveal a new concept for a role of the nucleosome as a docking site for other proteins...
  40. pmc Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements
    Pey Jium Chang
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 76:3168-78. 2002
    ..Two KSHV lytic-cycle promoters are activated by a similar mechanism that involves direct recognition of a homologous response element by the DNA binding domain of ORF 50 protein in the context of related cellular proteins...
  41. pmc Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
    Hongyu Deng
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 90095, USA
    J Virol 76:8252-64. 2002
    b>Human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus is linked to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), all of which are viewed as cytokine-driven malignancies...
  42. pmc Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus
    Mandana Mansouri
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Virol 82:9615-28. 2008
    ....
  43. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
    ..These findings suggest that Tat may participate in KS pathogenesis by inducing KSHV replication and increasing KSHV viral load. These data also suggest that JAK/STAT signaling may be of therapeutic value in AIDS-related KS patients...
  44. pmc Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
    K A Staskus
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Virol 73:4181-7. 1999
    b>Human herpesvirus 8 (HHV-8) infection has been implicated in the etiology of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), three diseases that frequently develop in immunocompromised, ..
  45. pmc Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus
    Mark A Samols
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
    J Virol 79:9301-5. 2005
    ..These data suggest that viral and host cellular gene expression may be regulated by miRNAs during both latent and lytic KSHV replication...
  46. pmc Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells
    A Krithivas
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 74:9637-45. 2000
    The human herpesvirus 8 (HHV-8) latency-associated nuclear antigen (LANA) is expressed in all latently HHV-8 infected cells and in HHV-8-associated tumors, including primary effusion lymphoma (PEL)...
  47. ncbi vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity
    Cristiano Salata
    Division of Microbiology and Virology, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    J Cell Physiol 219:698-706. 2009
    b>Human herpesvirus 8 (HHV-8) is a lymphotropic herpesvirus linked to several disorders such as Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease...
  48. pmc Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency
    Ke Lan
    Department of Microbiology, University of Pennsylvania Medical School, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:7453-65. 2005
    ..This describes a feedback mechanism by which LANA and RTA can regulate each other and is likely to be a key event in the establishment of KSHV latency...
  49. ncbi Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders
    M Q Du
    Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Blood 97:2130-6. 2001
    ..Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions. (Blood. 2001;97:2130-2136)..
  50. pmc Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis
    Shaw M Akula
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Virol 77:7978-90. 2003
    Kaposi's sarcoma (KS)-associated herpesvirus or human herpesvirus 8 (HHV-8) DNA and transcripts have been detected in the B cells, macrophages, keratinocytes, and endothelial and epithelial cells of KS patients...
  51. ncbi Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells
    S A Keller
    Weill Graduate School of Medical Sciences of Cornell University, and the Departments of Medicine and Pathology of Weill Medical College of Cornell University, New York, NY, USA
    Blood 96:2537-42. 2000
    ..These results suggest that NF-kappaB activity is necessary for survival of KSHV-infected lymphoma cells, and that pharmacologic inhibition of NF-kappaB may be an effective treatment for PEL...
  52. pmc Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells
    Jill T Bechtel
    Howard Hughes Medical Institute and Department of Microbiology and Medicine, University of California Medical Center, San Francisco 94143, USA
    J Virol 77:6474-81. 2003
    ....
  53. ncbi Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation
    Hittu Matta
    Hamon Center for Therapeutic Oncology Research and Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Biol Chem 278:52406-11. 2003
    ..Selective inhibitors of the IKK1 kinase activity may have a role in the treatment of disorders caused by abnormal NF-kappaB activation by HHV8 vFLIP K13...
  54. ncbi Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
    Subhash C Verma
    Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    FEMS Microbiol Lett 222:155-63. 2003
    ..LANA has now been shown to be a multifunctional protein involved in numerous cellular functions including binding to the retinoblastoma protein and p53, regulating cell proliferation and apoptosis...
  55. pmc Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus
    M J Song
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Jonnson Comprehensive Cancer Center, and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 75:3129-40. 2001
    b>Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of lytic replication...
  56. ncbi A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency
    Masahiro Fujimuro
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Med 9:300-6. 2003
    ..Redistribution of GSK-3beta can therefore be a source of beta-catenin dysregulation in human cancers...
  57. pmc Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression
    Sathish Sadagopan
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Virol 81:3949-68. 2007
    ..These results suggest that during de novo infection, KSHV induces sustained levels of NF-kappaB to regulate viral and host cell genes and thus possibly regulates the establishment of latent infection...
  58. pmc Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
    Yuying Liang
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, CA 94143 0414, USA
    Proc Natl Acad Sci U S A 100:8490-5. 2003
    ..RBP-J kappa-mediated repression is therefore not essential for establishment of latent infection, but the RTA-mediated redirection of RBP-J kappa activity from repression to activation is critical for lytic viral replication...
  59. pmc Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor
    Mildred Foster-Cuevas
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Virol 78:7667-76. 2004
    ..Here, we show that the product of the K14 open reading frame from human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) interacts with human CD200R and is expressed at the surfaces of ..
  60. pmc Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA
    M E Ballestas
    Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 75:3250-8. 2001
    Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) (also known as human herpesvirus 8) latently infects KS tumors, primary effusion lymphomas (PELs), and PEL cell lines...
  61. pmc The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway
    Christine C Tomlinson
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 78:1918-27. 2004
    ..Our observations suggest that the K1 viral protein promotes cell survival pathways and may contribute to KSHV pathogenesis by preventing virally infected cells from undergoing apoptosis prematurely...
  62. pmc Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1
    Subhash C Verma
    Department of Microbiology and Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 78:10348-59. 2004
    ..Together, our results suggest that the interaction of LANA with Sp1 up-regulates the telomerase promoter, potentially contributing to the immortalization of KSHV-infected cells...
  63. ncbi Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moieties
    S M Akula
    Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 284:235-49. 2001
    ..These results suggest that gB plays an important role in the infectious process of HHV-8 and virus interaction with cell-surface HS-like moieties could be in part mediated by the envelope-associated gB...
  64. ncbi Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-kappaB pathway
    Elisabetta Caselli
    Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy
    Blood 109:2718-26. 2007
    b>Human herpesvirus 8 (HHV-8) is considered the causative agent of Kaposi sarcoma, a highly vascularized neoplasm characterized by spindle-shaped cells of endothelial origin and inflammatory cell infiltration...
  65. pmc Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways
    Jianping Xie
    Tumor Virology Program, Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, USA
    Virology 371:139-54. 2008
    ..Together, these findings suggest that MAPK pathways might have general roles in regulating the life cycle of KSHV by mediating both viral infection and switch from viral latency to lytic replication...
  66. ncbi Human herpesvirus 8-negative malignant effusion lymphoma: a distinct clinical entity and successful treatment with rituximab
    Yosuke Matsumoto
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kyoto, Japan
    Leuk Lymphoma 46:415-9. 2005
    We describe 2 elderly patients with Human herpesvirus 8 (HHV-8)/Kaposi sarcoma herpes virus negative malignant effusion lymphoma showing pan-B-cell immunophenotyping markers and successfully treated with a chimeric anti-CD20 IgG1 ..
  67. pmc Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation
    Kyla Driscoll Carroll
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA
    J Virol 81:8451-67. 2007
    ..We propose a model in which Rta transactivation of the promoter is specified by the combination of DNA binding and interactions with several cellular DNA binding proteins including Oct-1...
  68. ncbi Latent and lytic HHV-8 mRNA expression in PBMCs and Kaposi's sarcoma skin biopsies of AIDS Kaposi's sarcoma patients
    Abeltje M Polstra
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Virol 70:624-7. 2003
    ..Thus, the HHV-8 DNA load in the PBMCs increases in more advanced Kaposi's sarcoma, as does the frequency of mRNA detection in PBMCs...
  69. ncbi Virokines in the pathogenesis of cancer: focus on human herpesvirus 8
    Mariam Klouche
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Ann N Y Acad Sci 1028:329-39. 2004
    ..We provide an overview of the role of virokines in cancer, with a particular focus on the differences of human and viral IL-6 in the pathophysiology of HHV8-associated tumors...
  70. pmc Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase
    Pei Ching Chang
    Department of Biological Chemistry and Molecular Medicine and University of California Davis Cancer Center, California 95817, USA
    Cancer Res 69:5681-9. 2009
    ..In summary, the cellular transcriptional repressor KAP-1 plays a role in regulating KSHV latency, and viral protein kinase modulates the chromatin remodeling function of this repressor...
  71. pmc Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genome
    Yiyang Xu
    University of Nevada, Reno, Department of Microbiology, 1664 North Virginia Street, Howard Bldg 210, Reno, NV 89557, USA
    J Virol 80:9905-9. 2006
    The lytic origins of DNA replication for human herpesvirus 8 (HHV8), oriLyt-L and oriLyt-R, are located between open reading frames K4.2 and K5 and ORF69 and vFLIP, respectively...
  72. pmc A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
    Adam Grundhoff
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    RNA 12:733-50. 2006
    ..The advantages and limitations of the approach are discussed...
  73. ncbi Human herpesvirus 8 virology, epidemiology and related diseases
    H Katano
    Department of Pathology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Jpn J Infect Dis 53:137-55. 2000
    b>Human herpesvirus 8 ([HHV-8], Kaposi's sarcoma-associated herpesvirus [KSHV]) is a novel human oncovirus classified as a gamma-herpesvirus...
  74. ncbi Classic type of Kaposi's sarcoma and human herpesvirus 8 infection in Xinjiang, China
    P Dilnur
    Second Department of Pathology, Tokyo Medical University, Japan
    Pathol Int 51:845-52. 2001
    ..Immunohistochemical examination of the lesions revealed that human herpesvirus 8 (HHV-8)-encoded latency-associated nuclear antigen was expressed in the nuclei of spindle-shaped tumor ..
  75. pmc Cytokine production by human herpesvirus 8-infected dendritic cells
    Heather R Hensler
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Gen Virol 90:79-83. 2009
    We have shown previously that human herpesvirus 8 (HHV-8)-infected dendritic cells (DCs) undergo incomplete maturation and have a defective antigen-presenting function...
  76. ncbi Epstein-Barr virus- and human herpesvirus 8-associated primary cutaneous plasmablastic lymphoma in the setting of renal transplantation
    Shannon Verma
    College of Medicine and Public Health, The Ohio State University, OH 43210 1218, USA
    J Cutan Pathol 32:35-9. 2005
    ..human immunodeficiency viral infection whereby a role for Epstein-Barr virus (EBV) and more recently human herpesvirus 8 (HHV8) has been described...
  77. pmc Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence
    Fu Zhang Wang
    Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Virol 77:3131-47. 2003
    b>Human herpesvirus 8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus, implicated in the pathogenesis of Kaposi's sarcoma, utilizes heparan sulfate-like molecules to bind the target cells via its envelope-associated glycoproteins gB and ..
  78. ncbi Age-specific seroprevalence of Human Herpesvirus 8 in Mediterranean regions
    P Cattani
    Institute of Microbiology, Universita Cattolica del Sacro Cuore, Rome, Italy
    Clin Microbiol Infect 9:274-9. 2003
    b>Human herpesvirus 8 (HHV8) is believed to be transmitted mainly by sexual contact; epidemiological data from Africa show, however, that non-sexual transmission routes may also play an important role...
  79. pmc Kaposi's sarcoma-associated herpesvirus modulates microtubule dynamics via RhoA-GTP-diaphanous 2 signaling and utilizes the dynein motors to deliver its DNA to the nucleus
    Pramod P Naranatt
    Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:1191-206. 2005
    b>Human herpesvirus 8 (HHV-8; also called Kaposi's sarcoma-associated herpesvirus), which is implicated in the pathogenesis of Kaposi's sarcoma (KS) and lymphoproliferative disorders, infects a variety of target cells both in vivo and in ..
  80. pmc Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5
    Qinglin Li
    Tumor Virology Division, New England Regional Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772, USA
    J Virol 81:2117-27. 2007
    ..These results suggest that KSHV K3 and K5 suppress both cytokine-mediated and cell-mediated immunity, which ensures efficient viral avoidance of host immune controls...
  81. pmc Quantitative membrane proteomics reveals new cellular targets of viral immune modulators
    Eric Bartee
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America
    PLoS Pathog 2:e107. 2006
    ..The unbiased global proteome analysis therefore revealed novel immunomodulatory functions of pathogen proteins...
  82. ncbi Virology, pathogenetic mechanisms, and associated diseases of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8)
    Ronit Sarid
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mayo Clin Proc 77:941-9. 2002
    ..This may also translate into improved treatment and perhaps prevention of this common and intriguing viral infection...
  83. ncbi Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors
    P E Pellett
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Transfusion 43:1260-8. 2003
    As part of assessing the possibility of transfusion transmission of human herpesvirus 8 (HHV-8 or Kaposi's sarcoma-associated herpesvirus), HHV-8 seroprevalence was estimated among US blood donors, the performance of HHV-8 serologic ..
  84. ncbi Oral plasmablastic lymphomas in AIDS patients are associated with human herpesvirus 8
    Adina M Cioc
    Department of Pathology, Ohio State University Medical Center and College of Dentistry, Columbus, OH 43210, USA
    Am J Surg Pathol 28:41-6. 2004
    ..Given the poor prognosis of oral cavity lymphomas in immunocompromised patients, therapy directed against the HHV8 and EBV infection may be of therapeutic value...
  85. pmc Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
    James R Boyne
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    PLoS Pathog 4:e1000194. 2008
    ..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production...
  86. pmc KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
    Don Ganem
    Department of Medicine and Microbiology, University of California, 513 Parnassus Ave, San Francisco, CA 91413, USA
    J Clin Invest 120:939-49. 2010
    ....
  87. ncbi Biology of Kaposi's sarcoma
    B Ensoli
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Eur J Cancer 37:1251-69. 2001
    ..forms that, however, share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8)...
  88. ncbi KSHV- and EBV-associated germinotropic lymphoproliferative disorder
    Ming Qing Du
    Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
    Blood 100:3415-8. 2002
    ..We propose calling this distinctive entity "KSHV-associated germinotropic lymphoproliferative disorder."..
  89. pmc Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt"
    Sheila C Dollard
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Int J Cancer 127:2395-401. 2010
    ..These findings help to explain the high KS incidence in the "KS Belt" and underscore the importance of a uniform approach to HHV-8 antibody testing...
  90. pmc Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway
    Faye Gould
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 83:6727-38. 2009
    ....
  91. pmc De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells
    Michael Lagunoff
    Department of Microbiology and Medicine, Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0414, USA
    J Virol 76:2440-8. 2002
    ..These findings suggest that either the stability or the growth-deregulatory potential of the KSHV latency program in endothelial cells is more limited than might be predicted by analogy with other oncogenic viruses...
  92. ncbi Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia
    Dimitra Bourboulia
    Wolfson Institute for Biomedical Research and the Department of Sexually Transmitted Diseases, University College London, London, UK
    AIDS 18:485-93. 2004
    ....
  93. ncbi The sero-epidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in adults with cancer in Uganda
    Robert Newton
    Cancer Research UK, Epidemiology Unit, Radcliffe Infirmary, Oxford, United Kingdom
    Int J Cancer 103:226-32. 2003
    ..The association between the prevalence of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8 [HHV-8]) and sociodemographic, sexual, reproductive and lifestyle factors was investigated in a study of ..
  94. ncbi Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in Uganda
    Sam M Mbulaiteye
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:1330-5. 2003
    Although human herpesvirus 8 (HHV-8), the etiologic agent for Kaposi's sarcoma, can be detected in peripheral blood, blood-borne transmission of this virus has not been demonstrated...
  95. ncbi Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR
    Carlos Bais
    Laboratory of Viral Oncogenesis, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Cell 3:131-43. 2003
    ..We conclude that vGPCR can cause an oncogenic immortalizing event and recapitulate aspects of the KS angiogenic phenotype in human endothelial cells, pointing to this gene as a pathogenic determinant of KSHV...
  96. ncbi Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus
    D A Davis
    HIV and AIDS Malignancy Branch, the Dermatology Branch, and the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 97:3244-50. 2001
    ..These studies suggest that hypoxia is an inducer of KSHV replication. This process may play an important role in the pathogenesis of KS...
  97. pmc DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
    A C Garber
    Division of Hematology/Oncology and Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 75:7882-92. 2001
    ..These data suggest that LANA, although fulfilling functions similar to those of EBNA-1, does so by very different mechanisms...
  98. ncbi Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs
    James R Boyne
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    FEBS Lett 583:3549-56. 2009
    ..We show that rapid disorganisation of the nucleolus was accompanied by a reduction in intronless virus mRNA export, suggesting that an intact nucleolus is essential for efficient KSHV ORF57-mediated intronless mRNA export...
  99. ncbi The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma
    Silvia Montaner
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, USA
    Cancer Res 66:168-74. 2006
    ....
  100. ncbi Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy
    M Coluzzi
    Dipartimento di Scienze di Sanità Pubblica, Universita La Sapienza, Roma, Italy
    Med Vet Entomol 17:461-4. 2003
    ..malarious parts of Italy, age-related seroprevalence rates of Kaposi's sarcoma-associated herpesvirus [human herpesvirus 8 (KSHV/HHV8)] were determined from local blood donors and correlated with periods of vector control during ..
  101. pmc Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
    Adam Grundhoff
    Howard Hughes Medical Institute and Department of Microbiology, University of California, San Francisco, San Francisco, California 94143 0414, USA
    J Clin Invest 113:124-36. 2004
    ..They also suggest an additional role for lytic replication in sustaining KS tumorigenesis: namely, the recruitment of new cells to latency to replace those that have segregated the viral episome...

Research Grants64

  1. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Human herpesvirus 8 (HHV8), more commonly referred to as Kaposi's Sarcoma (KS)-Associated Herpesvirus (KSHV) is the ..
  2. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ....
  3. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ....
  4. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ....
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..abstract_text> ..
  6. KSHV Lytic DNA Replication and its Control Mechanism
    Subhash C Verma; Fiscal Year: 2013
    ..in regulating lytic DNA replication of Kaposi's sarcoma associated herpesvirus (KSHV) also known as Human Herpesvirus 8 (HHV8)...
  7. Human Herpesvirus-8 Replication and Kaposi Sarcoma Response to Treatment
    Warren Phipps; Fiscal Year: 2013
    ....
  8. KSHV-Ori-Lyt-Dependent DNA Replication
    Yan Yuan; Fiscal Year: 2012
    ..The study aims to new therapeutic strategies to block KSHV replication and treat KSHV-associated human diseases. ..
  9. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) is the etiologic agent of KS, the most common cancer associated with HIV infection and AIDS...
  10. Rhesus HHV-8 homologue in AIDS-related malignancies
    Scott W Wong; Fiscal Year: 2013
    ..One virus that was recently identified to be associated with cancer in humans in 1995 is human herpesvirus 8 (HHV8)/Kaposi's sarcoma-associated herpesvirus (KSHV)...
  11. Genome Persistence of KSHV
    Erle S Robertson; Fiscal Year: 2013
    ....
  12. Inhibitory targeting of HHV-8 vIL-6-related interactions.
    John Nicholas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies a homologue of interleukin-6, vIL-6, which is implicated in the development and progression of HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (..
  13. Characterization of ER-localized Activity of HHV-8 Interleukin-6
    EMILY MARIE COUSINS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) has been etiologically linked to Kaposi sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL)...
  14. Targeting vFLIP for the treatment of KSHV-associated malignancies
    Ethel Cesarman; Fiscal Year: 2013
    ..KS is caused by the Kaposi's sarcoma herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8)...
  15. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents
    Terry L Bowlin; Fiscal Year: 2013
    ....
  16. Improved Diagnosis of Kaposi's Sarcoma Herpes Virus Infection
    Steven D Dong; Fiscal Year: 2013
    ..Achieving the goals in this project would generate a commercial HHV-8 diagnostic test which will identify infected patients and donors to reduce transmission risk and to make the blood supply safer. ..
  17. HHV-8, angiogenesis and inflammation
    Bala Chandran; Fiscal Year: 2011
    ..abstract_text> ..
  18. Early Events in KSVH Infection of Primary B-cells
    Erle S Robertson; Fiscal Year: 2013
    ..broader area of herpesvirus biology with insights into the mechanism of oncogenesis associated with other viruses including EBV and so reducing the burden of disease in the HIV infected, transplants and other immunocompromised population ..
  19. Infection of primary B cells by the human lymphomagenic pathogen HHV8
    Lynn M Hassman; Fiscal Year: 2012
    ..lymphoma (PEL) and multicentric Castleman's disease arise in immunocompromised patients harboring human herpesvirus 8 (HHV8), the same oncogenic pathogen underlying Kaposi's sarcoma...
  20. Multicenter AIDS Cohort Study - Part B (Baltimore Center)
    Joseph B Margolick; Fiscal Year: 2013
    ..SHARE and the MACS should continue to play a leading role in studies designed to lead to better treatments and preventive vaccines for HIV infection. ..
  21. Transmission of KSHV/HHV-8 in South Africa
    Lisa Michelle Butler; Fiscal Year: 2010
    ....
  22. Studies of HHV-8 vIL-6 Function
    John Nicholas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kaposi's sarcoma- and B cell lymphoma-associated human herpesvirus 8 (HHV-8) specifies particular proteins that are believed to contribute to angioproliferative and malignant pathogenesis...
  23. Develop a therapeutic vaccine approach by removing viral immune evasion
    Ren Sun; Fiscal Year: 2013
    ..Moreover, elucidating the anti-IFN function of a group of conserved viral proteins may reveal potential targets for therapeutic measures. ..
  24. Role of ROS and Nrf2 in HHV-8 infection and pathogenesis
    Virginie Bottero; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8/KSHV) is etiologically associated with Kaposi's Sarcoma (KS), primary effusive lymphoma (PEL), and multicentric Castleman disease (MCD)...
  25. Activities of HHV-8 vIRF-1 in Virus Biology
    John Nicholas; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies four viral interferon regulatory factor homologues (vIRFs) that function to inhibit cellular IRFs in addition to other components of cellular defense pathways ..
  26. Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization
    Ronald C Desrosiers; Fiscal Year: 2012
    ..The gamma-2 herpesvirus of rhesus monkeys, rhesus monkey rhadinovirus (RRV), will be used as a model of human herpesvirus 8 (HHV-8;the Kaposi sarcoma-associated herpesvirus) to define the viral glycoproteins required for entry into ..
  27. BH3-only protein targeting by HHV-8
    John Nicholas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) is associated with endothelial Kaposi's sarcoma (KS) and B cell malignancies primary effusion lymphoma and multicentric Castleman's disease, all of which occur ..
  28. Function of gammaherpesvirus ORF75 tegument proteins
    Laurie T Krug; Fiscal Year: 2013
    ....
  29. Antigens of Kaposi's sarcoma associated herpesvirus
    Bala Chandran; Fiscal Year: 2012
    ..abstract_text> ..
  30. MODULATION OF ONCOGENIC AGENTS BY MARIJUANA
    PETER GABOR MEDVECZKY; Fiscal Year: 2010
    ..8 million individuals who regularly use marijuana. We are not aware of any similar work performed in the past so this proposal represents the first study in this important area. ..
  31. A High Throughput Protein Complementation Assay for Inhibitors of NEMO-K13 Intera
    Preet M Chaudhary; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human Herpesvirus 8 (HHV8, also known as KSHV) is one of the commonest causes of malignancies among young adults in parts of the world and has been associated with Kaposi's sarcoma, primary ..
  32. Reactivation of Kaposi's sarcoma-associated herpesvirus
    Ren Sun; Fiscal Year: 2013
    ..It not only addresses a fundamental biological question, but also can facilitate the development of new preventive and/or therapeutic approaches. ..
  33. Role of Arsenic Trioxide in Primary Effusion Lymphoma
    Preet M Chaudhary; Fiscal Year: 2011
    ..We hope that these studies will lead to the development of less toxic and more effective molecularly targeted agents for the treatment of HHV8-associated lymphoproliferative disorders. ..
  34. Mechanisms of Action of LANA encoded by KSHV
    Erle S Robertson; Fiscal Year: 2011
    ....
  35. KSHV infection of human tonsillar B cells
    Dean H Kedes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8) establishes lifelong infection and is the etiologic agent underlying primary effusion lymphoma, ..
  36. Epidemiology of HHV-8 Transmission in Lusaka Zambia
    KAY LYNNE CRABTREE; Fiscal Year: 2010
    ..This information should lead to the development of strategies to facilitate behavioral changes to help decrease the incidence of infection in children and the development of KS. ..
  37. Immune surveillance in murine gammaherpesvirus infection
    Edward J Usherwood; Fiscal Year: 2013
    ..There is a good likelihood that therapies similar to those we describe will be effective in humans, and our studies provide essential information concerning their method of action. ..
  38. Mitochondrial-localized activities of HHV-8 vIRF-1
    John Nicholas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies four viral interferon regulatory factor homologues (vIRFs 1-4) that function to inhibit cellular IRFs in addition to other components of cellular defense ..
  39. Mitochondrial DRM targeting by HHV-8 viral interferon regulatory factor-1
    Young Bong Choi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) encodes non-structural proteins that regulate host cell antiviral mechanisms via multiple inhibitory interactions...
  40. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2013
    ..We anticipate that the data generated through the proposed effort will be useful in the development of future intervention strategies to prevent HHV-8 transmission. ..
  41. Regulation of the KSHV latent promoter
    Dirk P Dittmer; Fiscal Year: 2013
    ....
  42. Viral Pathogenesis Training Program
    Julie M Overbaugh; Fiscal Year: 2013
    ..Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. ..
  43. Impact of HIV and HHV-8 Co-Infection on Antiretroviral Therapy Efficacy in Africa
    Corey Casper; Fiscal Year: 2013
    ..Kaposi sarcoma (KS), the most common HIV-associated malignancy worldwide, is attributable to infection with human herpesvirus 8 (HHV-8)...
  44. KSHV proteins eliciting neutralizing antibodies and T cell responses
    Jeffrey Vieira; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is the etiologic agent of Kaposi's sarcoma (KS), and other proliferative disorders...
  45. Re-specification of the Notch response by the HHV-8 lytic switch protein
    David M Lukac; Fiscal Year: 2013
    ..This proposal will shed light on how Notch target genes are specified, and reveal new components of the Notch signal transduction pathway. ..
  46. VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma
    Parkash Gill; Fiscal Year: 2009
    ..This work is anticipated to enhance our understanding of KS pathogenesis, provide opportunities for novel therapies for KS, and contribute to the understanding of vascular biology. ..
  47. EPIDEMIOLOGY, SEXUAL TRANSMISSION OF HHV8 IN MALAWI
    Evelyn Quinlivan; Fiscal Year: 2000
    ..Specific Aim #4: To identify factors which influence the presence of HHV-8 DNA in the semen. Specific Aim #5: To determine the diversity of HHV-8 isolates in the Malawi cohort as compared to the prototype HHV8. ..
  48. PKB/Akt Activation and Cell Survival with HIV-1 Tat
    Felipe Samaniego; Fiscal Year: 2006
    ..b>Human herpesvirus 8 (HHV-8) is required for the development of KS but is insufficient to cause it unless a second factor, such ..
  49. ROLE OF VIL-6 IN PRIMARY EFFUSION LYMPHOMAS
    John Nicholas; Fiscal Year: 2004
    ..The generated data will provide the basis for the design of potentially therapeutic strategies to specifically block vIL-6 mitogenic functions with respect PEL and other HHV-8 associated diseases. ..
  50. KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMA
    Ethel Cesarman; Fiscal Year: 2001
    Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV 8), is invariably present in Kaposi's sarcoma (KS) lesions where it has been localized in the endothelial cells as well as in the spindle cells, which are ..
  51. CRITICAL ROLE OF HHV8 ENCODED IRF IN AIDS LYMPHOMAS
    PAULA PITHA ROWE; Fiscal Year: 2001
    ..Lastly, the vIRF transgenic mice may represent an experimental model for future therapeutical studies of AIDS-associated lymphomas. ..
  52. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2005
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
  53. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents
    Terry L Bowlin; Fiscal Year: 2010
    ..The overall goal of this proposal is to develop novel therapies for the emerging infectious diseases HHV-6 and HHV-8. ..
  54. BIOLOGICAL STUDIES IN KAPOSI'S SARCOMA
    PHILIP BROWNING; Fiscal Year: 2000
    ..Moreover, we recently discovered that these cells are infected with the proposed etiologic agent of KS, human herpesvirus 8 (HHV-8) and that transcripts for a viral homologue of cellular cyclin D are found in these cells...
  55. PHASE I/II STUDY OF FLAVOPIRIDOL IN KAPOSI'S SARCOMA
    PHILIP BROWNING; Fiscal Year: 2000
    ....
  56. Role of Interleukin-6 in Gammaherpesvirus replication
    Ren Sun; Fiscal Year: 2007
    ..Our continuous study will be critical to reveal the function of cellular and viral IL-6, a pair of intriguing and important molecules in the life cycle of KSHV. ..
  57. Viral Lysis of Kaposi's Sarcoma Tumor Cells
    Ren Sun; Fiscal Year: 2004
    ....
  58. HUMAN HERPESVIRUS 8 INFECTION IN ZIMBABWE
    Thomas Campbell; Fiscal Year: 2001
    ..of KS in persons with, and without AIDS has been linked to infection with the recently discovered human herpesvirus 8 (HHV-8; also called Kaposi's sarcoma-associated virus or KSHV)...
  59. HHV-8 VIRAL LOAD AND PROGRESSION TO KAPOSIS SARCOMA
    Frank Jenkins; Fiscal Year: 2000
    ..These results will also determine the rate of occurrence of detectable levels of HHV-8 DNA in the PBMCs from the time of HHV-8 seroconversion to the onset of KS. ..
  60. NATURAL HISTORY AND TRANSMISSION OF HHV8/KSHV
    Dennis Osmond; Fiscal Year: 2001
    ..Between 35 and 40 incident infections are expected over the four years of follow-up. The natural history of infection will be observed in 200 men with pre-existing HHV- 8/KSHV infection; 100 of these are HIV co-infected. ..
  61. Bim regulation by HHV-8 vIRF-1
    John Nicholas; Fiscal Year: 2009
    ..While several anti-apoptotic proteins believed to contribute to this function have been identified in human herpesvirus 8 (HHV-8), these are unlikely to comprise the full repertoire of HHV-8 mechanisms that together effectively ..
  62. HHV-8 IN PRIMARY EFFUSION LYMPHOMAS
    H Koeffler; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Description) Kaposi s sarcoma associated herpes virus/human herpesvirus 8 (HHV-8) is found in Kaposi's sarcoma (KS) and primary effusion lymphomas (PEL)...
  63. Effects of Ritonavir on HHV-8 vGPCR signaling and tumorigenesis
    Marvin Reitz; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8), the primary etiologic agent of Kaposi's sarcoma (KS), encodes vGPCR, a homologue of the human IL-8 receptor and a member of the G protein coupled ..
  64. MOLECULAR INTERACTIONS BETWEEN HIV-1 AND HHV-8
    Kimberly Foreman; Fiscal Year: 2002
    ..Such models will be particularly useful for devising new therapies for AIDS- KS. ..