human herpesvirus 3

Summary

Summary: The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.

Top Publications

  1. ncbi Varicella prevention in the United States: a review of successes and challenges
    Mona Marin
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A 47, Atlanta, GA 30333, USA
    Pediatrics 122:e744-51. 2008
  2. ncbi What does epidemiology tell us about risk factors for herpes zoster?
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Lancet Infect Dis 4:26-33. 2004
  3. pmc Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons
    Chantelle Hood
    Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, P O Box 412, Westmead, 2145 NSW, Australia
    J Virol 80:1025-31. 2006
  4. pmc Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
    J Virol 79:12658-66. 2005
  5. ncbi Epstein-Barr virus in pediatric multiple sclerosis
    Suad Alotaibi
    Department of Pediatrics Neurology, Al Sabah Hospital, Shuwaikh, Kuwait
    JAMA 291:1875-9. 2004
  6. ncbi Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread
    Qingxue Li
    Laboratory of Clinical Infectious Diseases, Medical Virology Section, National Institutes of Health, Bethesda, MD, 20892 USA
    Cell 127:305-16. 2006
  7. pmc Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferon-alpha
    Chia Chi Ku
    Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94305, USA
    J Exp Med 200:917-25. 2004
  8. pmc Productive varicella-zoster virus infection of cultured intact human ganglia
    Kavitha Gowrishankar
    Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
    J Virol 81:6752-6. 2007
  9. ncbi The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region
    A Nardone
    Health Protection Agency, Centre for Infections, London, UK
    Vaccine 25:7866-72. 2007
  10. pmc Functions of Varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infection
    Vaishali Chaudhuri
    Stanford University School of Medicine, 300 Pasteur Dr, S 354, Stanford, CA 94305, USA
    J Virol 82:10231-46. 2008

Research Grants

  1. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
  2. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
  3. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
  4. PEDIATRICS AIDS CLINICAL TRIALS GROUP
    Anne Gershon; Fiscal Year: 2006
  5. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
  6. ROLE OF VARICELLA ZOSTER VIRUS GLYCOPROTEIN B DURING VIR
    THOMAS HEINEMAN; Fiscal Year: 2003
  7. EGFP-Tagged VZV for the Study of Neuronal Infection
    THOMAS HEINEMAN; Fiscal Year: 2006
  8. Cdk inhibitors: novel antivirals for VZV
    Jennifer Moffat; Fiscal Year: 2007
  9. Cocaine Dependence: EEG Sleep and Cytokines
    Michael Irwin; Fiscal Year: 2005
  10. Alcoholism: Sleep and Cytokines in African Americans
    Michael Irwin; Fiscal Year: 2005

Detail Information

Publications237 found, 100 shown here

  1. ncbi Varicella prevention in the United States: a review of successes and challenges
    Mona Marin
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A 47, Atlanta, GA 30333, USA
    Pediatrics 122:e744-51. 2008
    ..The objective of this review was to summarize the US experience with the 1-dose varicella vaccination program, present the evidence considered for the policy change, and outline future challenges of the program...
  2. ncbi What does epidemiology tell us about risk factors for herpes zoster?
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Lancet Infect Dis 4:26-33. 2004
    ..We suggest areas of research that could lead to interventions to limit the incidence of zoster. Such research might also help to identify risk factors for age-related immune decline...
  3. pmc Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons
    Chantelle Hood
    Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, P O Box 412, Westmead, 2145 NSW, Australia
    J Virol 80:1025-31. 2006
    ..As ORF63 is expressed in neurons during both productive and latent infection, it may play a significant role in viral pathogenesis by promoting neuron survival during primary and reactivated infections...
  4. pmc Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
    J Virol 79:12658-66. 2005
    ..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection...
  5. ncbi Epstein-Barr virus in pediatric multiple sclerosis
    Suad Alotaibi
    Department of Pediatrics Neurology, Al Sabah Hospital, Shuwaikh, Kuwait
    JAMA 291:1875-9. 2004
    ..Infection with common viruses, particularly Epstein-Barr virus (EBV), has been postulated to contribute to the pathobiology of multiple sclerosis (MS). Detailed virological studies in pediatric MS have not been previously reported...
  6. ncbi Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread
    Qingxue Li
    Laboratory of Clinical Infectious Diseases, Medical Virology Section, National Institutes of Health, Bethesda, MD, 20892 USA
    Cell 127:305-16. 2006
    ..These studies indicate that IDE is a cellular receptor for both cell-free and cell-associated VZV...
  7. pmc Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferon-alpha
    Chia Chi Ku
    Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94305, USA
    J Exp Med 200:917-25. 2004
    ..Modulation of VZV replication by cutaneous innate immunity may avoid an incapacitating infection of the host that would limit opportunities for VZV transmission...
  8. pmc Productive varicella-zoster virus infection of cultured intact human ganglia
    Kavitha Gowrishankar
    Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
    J Virol 81:6752-6. 2007
    ..This model enables VZV infection of ganglionic cells to be studied in the context of intact DRG...
  9. ncbi The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region
    A Nardone
    Health Protection Agency, Centre for Infections, London, UK
    Vaccine 25:7866-72. 2007
    ..There are substantial differences in VZV sero-epidemiology within the European region, which will need to be taken into account in designing national policies regarding VZV vaccination...
  10. pmc Functions of Varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infection
    Vaishali Chaudhuri
    Stanford University School of Medicine, 300 Pasteur Dr, S 354, Stanford, CA 94305, USA
    J Virol 82:10231-46. 2008
    ..If so, ORF23 expression could be a target for a novel antiviral drug against VZV...
  11. ncbi Herpesviral protein networks and their interaction with the human proteome
    Peter Uetz
    Institut fur Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Karlsruhe, D 76021 Germany
    Science 311:239-42. 2006
    ..The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies...
  12. ncbi Simian varicella: a model for human varicella-zoster virus infections
    Wayne L Gray
    Department of Microbiology and Immunology, 4301 West Markham Street, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Rev Med Virol 14:363-81. 2004
    ....
  13. pmc Prevalence and abundance of latently transcribed varicella-zoster virus genes in human ganglia
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
    J Virol 81:2950-6. 2007
    ....
  14. ncbi Herpes simplex virus-1 and varicella-zoster virus latency in ganglia
    Bradley M Mitchell
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    J Neurovirol 9:194-204. 2003
    ..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
  15. pmc Varicella-Zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model
    Chia Chi Ku
    Stanford University School of Medicine, 300 Pasteur Dr, Room G 311, Stanford, CA 94305 5119, USA
    J Virol 79:2651-8. 2005
  16. ncbi The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination
    Hester de Melker
    Centre for Infectious Disease Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:3946-52. 2006
    ..Insight into epidemiology of varicella zoster is needed for the assessment of the desirability of introduction of routine varicella zoster vaccination...
  17. pmc The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor
    Qingxue Li
    Laboratory of Clinical Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:8525-32. 2007
    ..The amino portion of IDE, as well an IDE mutant in the catalytic domain of the protein, bound to gE. Therefore, distinct motifs of VZV gE are important for binding to IDE or to gI...
  18. pmc Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model
    Takahiro Niizuma
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 77:6062-5. 2003
    ..Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection...
  19. pmc Varicella-zoster virus productively infects mature dendritic cells and alters their immune function
    Gavin Morrow
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 77:4950-9. 2003
    ..Thus, VZV has evolved yet another immune evasion strategy that would likely impair immunosurveillance and enhance the chances for lifelong persistence in the human population...
  20. pmc Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal ganglia
    Lee Gary
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Virol 80:4921-6. 2006
    ..Together, these data indicate that the expression of the two latency-related VZV genes, ORFs 62 and 63, is regulated epigenetically through chromatin structure...
  21. ncbi Viral and cellular gene transcription in fibroblasts infected with small plaque mutants of varicella-zoster virus
    Jeremy O Jones
    Department of Pediatrics, Stanford University, 300 Pasteur Drive, Rm G312, Stanford, CA, USA
    Antiviral Res 68:56-65. 2005
    ....
  22. ncbi Polymerase chain reaction and restriction fragment length polymorphism analysis of varicella-zoster virus isolates from the United States and other parts of the world
    P LaRussa
    Columbia University, New York City, New York, USA
    J Infect Dis 178:S64-6. 1998
    ..At this point, there is no evidence that wt strains resembling the vaccine are circulating outside of Japan. This indicates that this PCR assay can be utilized to distinguish rashes due to vaccine and wt VZV...
  23. ncbi Laboratory diagnosis of herpes zoster
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Erfurt, Germany
    J Clin Virol 14:31-6. 1999
    ..These findings suggest that PCR is the method of choice for rapid laboratory diagnosis of zoster...
  24. pmc Laser-capture microdissection: refining estimates of the quantity and distribution of latent herpes simplex virus 1 and varicella-zoster virus DNA in human trigeminal Ganglia at the single-cell level
    Kening Wang
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 79:14079-87. 2005
    ..These data indicate that both HSV-1 and VZV DNAs persist in human TG primarily, if not exclusively, in a moderate percentage of neuronal cells...
  25. pmc Varicella-Zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral response
    Aruna P N Ambagala
    Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 81:7844-51. 2007
    ..Since IFN-alpha has been shown to limit VZV replication in human skin xenografts, the ability of VZV IE63 to block the effects of the cytokine may play a critical role in VZV pathogenesis...
  26. ncbi Replication of varicella-zoster virus is influenced by the levels of JNK/SAPK and p38/MAPK activation
    Markus Rahaus
    University of Witten Herdecke, Institute of Microbiology and Virology, Stockumer Str 10, D 58448 Witten, Germany
    J Gen Virol 85:3529-40. 2004
    ....
  27. pmc Downregulation of varicella-zoster virus (VZV) immediate-early ORF62 transcription by VZV ORF63 correlates with virus replication in vitro and with latency
    Susan E Hoover
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 80:3459-68. 2006
    ..The ability of ORF63 to downregulate ORF62 transcription may play an important role in virus replication and latency...
  28. ncbi The molecular epidemiology of varicella-zoster virus: evidence for geographic segregation
    Mark Quinlivan
    Department of Medical Microbiology, School of Medicine, Queen Mary College, London, United Kingdom
    J Infect Dis 186:888-94. 2002
    ..We used the BglI site to examine both the spread of type A viruses in the United Kingdom and the patterns of VZV infections within persons from different ethnic groups who grew up in the United Kingdom or abroad...
  29. pmc Varicella-zoster virus
    A M Arvin
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5119, USA
    Clin Microbiol Rev 9:361-81. 1996
    ..A live attenuated varicella vaccine (Oka/Merck strain) is now recommended for routine childhood immunization...
  30. pmc Toward universal varicella-zoster virus (VZV) genotyping: diversity of VZV strains from France and Spain
    Vladimir Loparev
    Biotechnology Core Facility, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 45:559-63. 2007
    ..The two genotyping methods, using entirely different genomic targets, produced identical clusters for the strains examined, suggesting robust phylogenetic linkages among VZV strains circulating in Europe...
  31. pmc Downregulation of class I major histocompatibility complex surface expression by varicella-zoster virus involves open reading frame 66 protein kinase-dependent and -independent mechanisms
    Amie J Eisfeld
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Virol 81:9034-49. 2007
    ..5 revealed no effects on MHC-I. These results establish a new role for viral protein kinases in immune evasion and suggest that VZV utilizes unique mechanisms to inhibit antigen presentation...
  32. pmc Genetic analysis of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome system
    Zhen Zhang
    Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, 225 Warren Street, Newark, NJ 07101 1709, USA
    J Virol 81:9024-33. 2007
    ..This work has validated and justified the use of the novel luciferase VZV BAC system to efficiently generate recombinant VZV variants and ease subsequent viral growth kinetic analysis both in vitro and in vivo...
  33. pmc Complete-genome phylogenetic approach to varicella-zoster virus evolution: genetic divergence and evidence for recombination
    Peter Norberg
    Department of Clinical Virology, Goteborg University, Guldhedsgatan 10B, 413 46 Goteborg, Sweden
    J Virol 80:9569-76. 2006
    ..In addition, we report here six novel genomic targets located in open reading frames 51 to 58 suitable for genotyping of clinical VZV isolates...
  34. pmc A full-genome phylogenetic analysis of varicella-zoster virus reveals a novel origin of replication-based genotyping scheme and evidence of recombination between major circulating clades
    Geoffrey A Peters
    National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Virol 80:9850-60. 2006
    ..The very low rate of single-nucleotide polymorphisms scattered across the genome made full-genome sequencing the only definitive method for identifying specific VZV recombination events...
  35. pmc Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivo
    Xibing Che
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    J Virol 80:3238-48. 2006
    ..We conclude that ORF10 protein is required for efficient VZV virion assembly and is a specific determinant of VZV virulence in epidermal and dermal cells in vivo...
  36. ncbi An animal model of varicella virus infection
    T M White
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Pathol 11:475-9. 2001
    ..Nevertheless, clinical, pathological, and molecular similarities between SVV and VZV indicate that SVV infection in non-human primates has considerable potential as an animal model for human varicella...
  37. pmc Lineages of varicella-zoster virus
    Duncan J McGeoch
    Medical Research Council Virology Unit, Institute of Virology, University of Glasgow, Glasgow G11 5JR, UK
    J Gen Virol 90:963-9. 2009
    Relationships among varicella-zoster virus (VZV; Human herpesvirus 3) genome sequences were examined to evaluate descent of strains, structures of lineages and incidence of recombination events...
  38. ncbi Outbreak of varicella at a day-care center despite vaccination
    Karin Galil
    Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 347:1909-15. 2002
    ..We investigated an outbreak of varicella in a population of children with a high proportion of vaccinees who were attending a day-care center in a small community in New Hampshire...
  39. ncbi Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination between microorganism-driven and polyspecific immune response
    C Jacobi
    Neurochemistry Laboratory, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    J Neuroimmunol 187:139-46. 2007
    ..So this concept gains increasingly relevance for analysis of the polyspecific immune response in brain...
  40. ncbi Varicella-zoster virus ORF1 gene product is a tail-anchored membrane protein localized to plasma membrane and trans-Golgi network in infected cells
    Tetsuo Koshizuka
    Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7 6 8, Saito Asagi, Ibaraki, Osaka 567 0085, Japan
    Virology 377:289-95. 2008
    ..These results show that the N terminus of ORF1 protein faces the cytoplasm in infected cells and the tegument region in mature virions...
  41. pmc Phylogenetic analysis of varicella-zoster virus: evidence of intercontinental spread of genotypes and recombination
    Winsome Barrett Muir
    School of Medicine, Queen Mary College, University of London, London E1 1BB, England
    J Virol 76:1971-9. 2002
    ..However, at least one probable recombinant between two of the major strains was found among the samples originating from Brazil, where mixtures of genotypes co-occur...
  42. ncbi Seroprevalence of varicella in the French population
    Babak Khoshnood
    Cemka Eval, Bourg la Reine, France
    Pediatr Infect Dis J 25:41-4. 2006
    ..To assess the age-specific seroprevalence of varicella in the French population and to explore age-adjusted differences according to gender and geographic region...
  43. ncbi Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster
    Jason J Chen
    Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    Cell 119:915-26. 2004
    ..Biopsies from VZV-infected human skin supported the idea that because MPRci expression is naturally lost in maturing superficial epidermal cells, these cells do not divert VZV to endosomes and constitutively secrete infectious VZV...
  44. pmc Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo
    Jeremy O Jones
    Department of Pediatrics, Stanford University, California 94305, USA
    J Virol 77:1268-80. 2003
    ....
  45. ncbi Viral strain identification in varicella vaccinees with disseminated rashes
    P LaRussa
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Pediatr Infect Dis J 19:1037-9. 2000
    ..Although some vaccinees will develop zoster, it is less common in recipients of vaccine than in those who have had natural varicella...
  46. pmc Enumeration of an extremely high particle-to-PFU ratio for Varicella-zoster virus
    John E Carpenter
    Central Microscopy Research Facility, University of Iowa, Iowa City, Iowa 52242, USA
    J Virol 83:6917-21. 2009
    ..We enumerated the total number of viral particles within 25 cm(2) of the infected monolayer at 415 million. Based on these numbers, the VZV particle:PFU ratio was approximately 40,000:1 for a cell-free inoculum...
  47. ncbi Use of genomic analysis of varicella-zoster virus to investigate suspected varicella-zoster transmission within a renal unit
    P J Molyneaux
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Clin Virol 36:76-8. 2006
    ..The source of hospital-acquired chickenpox infection may be presumed from a known exposure, but has not been previously proven using genomic analysis...
  48. pmc Cholesterol dependence of varicella-zoster virion entry into target cells
    S Hambleton
    Department of Paediatric, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Virol 81:7548-58. 2007
    ..Lipid rafts are likely to contribute directly to viral envelope integrity and, in the host membrane, may influence endocytosis, evoke downstream signaling, and/or facilitate membrane fusion...
  49. ncbi Susceptibility of New Entrant University students in Sri Lanka to varicella zoster infection
    G M P C P Kurukulasooriya
    Departments of Microbiology, University of Peradeniya, Sri Lanka
    Asia Pac J Public Health 22:219-24. 2010
    ..1% ( 25/247). The present study indicates that nearly half (222/436) of the study population (50.9%, 95% CI 46.2-55.6) was susceptible to VZV infection...
  50. ncbi Different genotype pattern of varicella-zoster virus obtained from patients with varicella and zoster in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 79:1025-31. 2007
    ..As reasons, the spread of viruses, which may be imported originally by persons immigrating from warmer climates, or the recombination between wild-and vaccine-type viruses have to be considered...
  51. ncbi VZV infection in pregnancy: a retrospective review over 5 years in Sheffield and discussion on the potential utilisation of varicella vaccine in prevention
    M W McKendrick
    Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK
    J Infect 55:64-7. 2007
    ..To study retrospectively the epidemiology, demography and clinical issues related to varicella in pregnancy in a UK city over a 5-year period and help inform the debate on the potential of varicella immunisation in prevention...
  52. ncbi Chickenpox
    Sophie Hambleton
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Opin Infect Dis 18:235-40. 2005
    ..Epidemiological data continue to accumulate that will inform decision-making on vaccine use elsewhere. These findings, together with relevant advances in VZV virology, form the substance of this review...
  53. ncbi The out of Africa model of varicella-zoster virus evolution: single nucleotide polymorphisms and private alleles distinguish Asian clades from European/North American clades
    Timothy R Wagenaar
    Department of Microbiology, University of Iowa College of Medicine, University of Iowa Hospital 2501 JCP, 200 Hawkins Drive, Iowa City, IA 42242, USA
    Vaccine 21:1072-81. 2003
    ....
  54. ncbi Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity
    Lionel Habran
    Laboratory of Virology and Immunology, Center for Biomedical Genoproteomics, Institute of Pathology B23, University of Liege, B 4000, Liege, Belgium
    J Biol Chem 280:29135-43. 2005
    ..These observations clearly demonstrated the importance of CDK1-mediated IE63 phosphorylation for a correct distribution of IE63 between both cellular compartments and for its repressive activity toward the promoter tested...
  55. ncbi Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus
    Louise Jones
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford, UK
    Eur J Immunol 37:3393-403. 2007
    ..In summary these data implicate persistent low-level or recurrent VZV antigen exposure in healthy immune donors and are compatible with a role for IE63-specific CD4+ T cells in the control of viral reactivation...
  56. ncbi Immunization with a DNA vaccine expressing a truncated form of varicella zoster virus glycoprotein E
    U A Hasan
    Department of Immunology, St Bartholomew s and the Royal London School of Medicine and Dentistry, EC1A 7BE, London, UK
    Vaccine 20:1308-15. 2002
    ..This observation indicates that immunization with a truncated form of a gene may induce immune modulation, a phenomenon that should be taken into account for the design of vaccines...
  57. pmc Global identification of three major genotypes of varicella-zoster virus: longitudinal clustering and strategies for genotyping
    Vladimir N Loparev
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 78:8349-58. 2004
    ..These data highlight the direction for future VZV genotyping efforts. This approach provides the first simple genotyping method for VZV strains in clinical samples...
  58. ncbi Genomic cartography of varicella-zoster virus: a complete genome-based analysis of strain variability with implications for attenuation and phenotypic differences
    S D Tyler
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
    Virology 359:447-58. 2007
    ..Although VZV has been considered to be one of the most genetically stable human herpesviruses, this initial assessment of genomic VZV cartography provides insight into ORFs with previously unreported variations...
  59. ncbi Investigations of the pathogenesis of Varicella zoster virus infection in the SCIDhu mouse model
    Ann M Arvin
    Departments of Pediatrics, and Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Herpes 13:75-80. 2006
    ..This would be characterized by the retention of infectivity in skin combined with a restricted tropism for T-cells and neurons within sensory ganglia...
  60. pmc T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection
    Anne Schaap
    Department of Pediatrics, Stanford University School of Medicine, CA 94305 5208, USA
    J Virol 79:12921-33. 2005
    ..These observations suggest that the ORF66 kinase plays a unique role during infection of T cells and supports VZV T-cell tropism by contributing to immune evasion and enhancing survival of infected T cells...
  61. pmc Cellular and viral factors regulate the varicella-zoster virus gE promoter during viral replication
    Barbara Berarducci
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Rm G312, Stanford, CA 94305 5208, USA
    J Virol 81:10258-67. 2007
    ..These results indicate that Sp1 is required for IE62-mediated transactivation of the gE promoter and that this transcriptional factor appears to be the only cellular factor essential for regulation of the gE promoter...
  62. ncbi [Disseminated herpes zoster in diabetes mellitus]
    N Graue
    Universitatsklinikum Essen, Klinik und Poliklinik fur Dermatologie, Venerologie und Allergologie, Hufelandstrasse 55, 45147 Essen
    Dtsch Med Wochenschr 131:384-6. 2006
    ..Type 2 diabetes mellitus type 2 had been diagnosed 20 years ago and had not been treated for the last 5 years. Therapy had been discontinued by the patient...
  63. pmc Persistent detection of varicella-zoster virus DNA in a previously healthy child after severe chickenpox
    Mireille T M Vossen
    Academic Medical Center, Emma Children s Hospital, Room G8 205, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 43:5614-21. 2005
    ..In contrast, during the persistent phase of VZV DNA detection, the viral DNA was primarily located in CD8(+) T cells. For the first time, we describe the persistent detection of VZV DNA in a previously healthy child...
  64. ncbi Serological detection of specific IgG to varicella-zoster virus by novel ELISA based on viral glycoprotein antigen
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Clin Lab 55:1-7. 2009
    ..For determination of immunity post vaccination, a different approach for the interpretation of borderline results should be considered...
  65. ncbi New mosaic subgenotype of varicella-zoster virus in the USA: VZV detection and genotyping by oligonucleotide-microarray
    Nikolay Sergeev
    Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, Division of Life Sciences, Silver Spring, MD 20993, USA
    J Virol Methods 136:8-16. 2006
    ..5%), J (3%) and M (15.5%). In addition, a new M variant (M3) was identified...
  66. ncbi Susceptibility to varicella in childbearing age women, Central Italy: is there a need for vaccinating this population group?
    Valeria Alfonsi
    Istituto Superiore di Sanita, National Center for Epidemiology Surveillance and Health Promotion, Italy
    Vaccine 25:6086-8. 2007
    ..This study further supports the importance of vaccinating susceptible adolescents and women of childbearing age in order to reduce both maternal and foetal complications associated with varicella in pregnancy...
  67. doi Humoral and cellular immunity to varicella-zoster virus: an overview
    Ann M Arvin
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Infect Dis 197:S58-60. 2008
  68. ncbi The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy
    M A Nagel
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 68:1069-73. 2007
    ..Diagnosis relies on virologic confirmation that detects VZV DNA, anti-VZV IgG antibody, or both in the CSF...
  69. ncbi Differences in varicella-zoster virus seroepidemiology between temperate and tropical regions
    Andreas Sauerbrei
    Indian J Med Sci 61:123-4. 2007
  70. ncbi Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients
    M Robinson-Agramonte
    Neuroimmunology Department, International Center for Neurological Restoration, Havana City, Cuba
    Acta Neurol Scand 115:312-8. 2007
    ..Intrathecal measles(M)- rubella(R)- and varicella zoster(Z)-antibody synthesis in German and Cuban multiple sclerosis (MS) patients are compared considering the different rubella epidemiology in the tropics...
  71. pmc Effect of viral load on the outcome of herpes zoster
    M L Quinlivan
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, and The London School of Medicine and Dentistry, Queen Mary College, London, UK
    J Clin Microbiol 45:3909-14. 2007
    ..Prodromal pain was significantly associated with higher baseline viral loads. Viral load levels were not associated with the development or persistence of PHN at 6, 12, or 26 weeks...
  72. pmc Identification of five major and two minor genotypes of varicella-zoster virus strains: a practical two-amplicon approach used to genotype clinical isolates in Australia and New Zealand
    Vladimir N Loparev
    Centers for Disease Control and Prevention, National Center for Preparedness, Detection, and Control of Infectious Diseases, Atlanta, Georgia 30333, USA
    J Virol 81:12758-65. 2007
    ..Two-amplicon typing was in complete accord with genotypes derived using SNP in multiple ORFs (ORFs 1, 21, 22, 38, 50, 54, and 62). Two additional minor genotypes, M3 and M4, could also be resolved using two-amplicon typing...
  73. ncbi Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    Michael B Rothberg
    Division of General Medicine and Geriatrics, Department of Medicine, Baystate Medical Center, Springfield, MA 01199, USA
    Clin Infect Dis 44:1280-8. 2007
    ..A vaccine to prevent herpes zoster was recently approved by the United States Food and Drug Administration. We sought to determine the cost-effectiveness of this vaccine for different age groups...
  74. pmc Serological detection of varicella-zoster virus-specific immunoglobulin G by an enzyme-linked immunosorbent assay using glycoprotein antigen
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, University Clinic of Jena, Postfach, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Clin Microbiol 44:3094-7. 2006
    ..The test can also be recommended for measuring antibody response after varicella vaccination, particularly after the cutoff value was optimized...
  75. ncbi A novel varicella-zoster virus gE mutation discovered in two Swedish isolates
    Benita Zweygberg Wirgart
    Department of Clinical Microbiology, Karolinska University Hospital, L2 02, SE 171 76 Stockholm, Sweden
    J Clin Virol 37:134-6. 2006
    ..Two VZV glycoprotein E (gE D150N) mutant strains were collected in North America in 1995 and in 1999. We now report a novel VZV gE mutant virus discovered in Europe in two VZV strains collected in Stockholm, Sweden, in 1990 and 1999...
  76. ncbi A study of varicella zoster virus glycoprotein C regulatory region response to viral activators in vitro
    Sara Gharavi
    Department of Biology, Alzahra University, Tehran, Iran
    Pak J Biol Sci 10:2140-5. 2007
    ....
  77. ncbi Molecular studies of Varicella zoster virus
    Mark Quinlivan
    Centre for Infectious Diseases, Institute for Cell and Molecular Science, 4 Newark Street, Whitechapel, London, E1 2AT, UK
    Rev Med Virol 16:225-50. 2006
    ..In addition, a rat model has been developed and successfully used to uncover which viral proteins are important for both the establishment and maintenance of latent VZV infection...
  78. pmc Varicella-zoster virus glycoprotein M homolog is glycosylated, is expressed on the viral envelope, and functions in virus cell-to-cell spread
    Yoshiaki Yamagishi
    Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7 6 8, Saito Asagi, Ibaraki, Osaka 567 0085, Japan
    J Virol 82:795-804. 2008
    ..These results showed that VZV gM is important for efficient cell-to-cell virus spread in cell culture, although it is not essential for virus growth...
  79. ncbi Transmission of a newly characterized strain of varicella-zoster virus from a patient with herpes zoster in a long-term-care facility, West Virginia, 2004
    Adriana S Lopez
    National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 197:646-53. 2008
    ....
  80. pmc Replication of varicella-zoster virus in human skin organ culture
    Shannon L Taylor
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Virol 79:11501-6. 2005
    ..The SOC system for VZV replication has applications for testing virus mutants and antiviral drugs...
  81. ncbi Herpes zoster guideline of the German Dermatology Society (DDG)
    G Gross
    Universit├Ątsklinik und Poliklinik f├╝r Dermatologie und Venerologie, Rostock, Augustenstr 80 84, D 18055, Rostock, Germany
    J Clin Virol 26:277-89; discussion 291-3. 2003
    ..Thus early presentation to a pain therapist is recommended in specific cases...
  82. pmc Varicella-zoster virus open reading frame 2 encodes a membrane phosphoprotein that is dispensable for viral replication and for establishment of latency
    Hitoshi Sato
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 1888, USA
    J Virol 76:3575-8. 2002
    ..Thus, ORF2 is the first VZV gene shown to be dispensable for establishment of latent infection in an animal model...
  83. pmc The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency
    Jeffrey I Cohen
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, Bldg 10, Room 11N228, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892, USA
    J Virol 78:11833-40. 2004
    ..Since the present vaccine can reactivate and cause shingles, a VZV vaccine based on the ORF63 mutant virus might be safer...
  84. pmc Simian varicella virus DNA in dorsal root ganglia
    R Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262
    Proc Natl Acad Sci U S A 88:2750-2. 1991
    ..Our results suggest that SVV becomes latent in monkey ganglia and that latency can develop in the absence of clinical varicella (chickenpox). These studies provide an animal model system to study varicella virus latency...
  85. pmc Varicella-zoster virus infection of human neural cells in vivo
    Armin Baiker
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:10792-7. 2004
    ..The chimeric nonobese diabetic severe combined immunodeficient mouse model may be useful for investigating other neurotropic human viruses...
  86. pmc Complete DNA sequence analyses of the first two varicella-zoster virus glycoprotein E (D150N) mutant viruses found in North America: evolution of genotypes with an accelerated cell spread phenotype
    Charles Grose
    Department of Pediatrics, University of Iowa, Iowa City, 52242, USA
    J Virol 78:6799-807. 2004
    ..The genomic results also expanded the evolutionary database by identifying which VZV ORFs were more likely to mutate over time...
  87. ncbi Encephalitis related to primary varicella-zoster virus infection in immunocompetent children
    M Hausler
    Department of Pediatrics, Pediatric Neurology Division, University Hospital, RWTH Aachen, Pauwelsstr 30, D 52074, Aachen, Germany
    J Neurol Sci 195:111-6. 2002
    ..Encephalitis is a rare complication of primary varicella-zoster virus (VZV) infection in immunocompetent children...
  88. pmc Utility of a multiplex PCR assay for detecting herpesvirus DNA in clinical samples
    Julian Druce
    Victorian Infectious Diseases Reference Laboratory VIDRL, 10 Wreckyn Street, North Melbourne 3051, Victoria, Australia
    J Clin Microbiol 40:1728-32. 2002
    ....
  89. pmc Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Neurol 54:459-63. 2003
    ..This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause...
  90. ncbi Memory cytotoxic T cell responses to viral tegument and regulatory proteins encoded by open reading frames 4, 10, 29, and 62 of varicella-zoster virus
    Ann M Arvin
    Department of Pediatrics Stanford University School of Medicine, Stanford, California 94305, USA
    Viral Immunol 15:507-16. 2002
    ..Adaptive immunity to VZV is characterized by a broad repertoire of memory CTL responses to proteins that comprise the virion tegument and regulate viral gene expression in infected cells...
  91. pmc New variant of varicella-zoster virus
    Graham A Tipples
    National Microbiology Laboratory, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 8:1504-5. 2002
    ..We isolated another VZV-MSP-like virus from an elderly man with herpes zoster. These gE mutant viruses may have arisen through independent mutation or may represent a distinct VZV subpopulation that emerged more than 50 years ago...
  92. pmc Changes in age related seroprevalence of antibody to varicella zoster virus: impact on vaccine strategy
    G Kudesia
    Public Health Laboratory, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    J Clin Pathol 55:154-5. 2002
    ..To study changes in the seroprevalence of varicella zoster virus (VZV) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy...
  93. ncbi Translation of varicella-zoster virus genes during human ganglionic latency
    Esther Grinfeld
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Scotland, UK
    Virus Genes 29:317-9. 2004
    ..These proteins were detected mainly in the neuronal cytoplasm, are likely to be present in low abundance during VZV latency, and mirror the profile of VZV gene transcription...
  94. pmc Varicella-zoster virus gene expression in latently infected and explanted human ganglia
    P G Kennedy
    Glasgow University Department of Neurology, Southern General Hospital, Glasgow, United Kingdom
    J Virol 74:11893-8. 2000
    ..Taken together, these data provide further support for the notion of significant and restricted viral gene expression in VZV latency...
  95. pmc The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse
    J F Moffat
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:11969-74. 1998
    ..The requirement for ORF47 expression in T cells and skin indicates that this gene product, which is dispensable in vitro, has a critical role within differentiated cells that are essential targets for VZV pathogenesis in vivo...
  96. ncbi Varicella-zoster virus (VZV) ORF65 virion protein is dispensable for replication in cell culture and is phosphorylated by casein kinase II, but not by the VZV protein kinases
    J I Cohen
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 280:62-71. 2001
    ..Thus, VZV ORF65 more closely resembles its pseudorabies virus homolog in its localization in infected cells and virions...
  97. ncbi A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    M N Oxman
    Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    N Engl J Med 352:2271-84. 2005
    ..We tested the hypothesis that vaccination against VZV would decrease the incidence, severity, or both of herpes zoster and postherpetic neuralgia among older adults...
  98. pmc Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus
    M H Sommer
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    J Virol 75:8224-39. 2001
    ..Finally, all of the deletion mutants that yielded recombinants retained infectivity for human T cells in vitro and replicated efficiently in human skin in the SCIDhu mouse model of VZV pathogenesis...
  99. pmc Characterization of Varicella-Zoster virus glycoprotein K (open reading frame 5) and its role in virus growth
    C Mo
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 73:4197-207. 1999
    ..Our results are consistent with the studies of gK proteins of HSV-1 and PRV showing that gK is indispensable for viral replication...
  100. pmc Role of the varicella-zoster virus gene product encoded by open reading frame 35 in viral replication in vitro and in differentiated human skin and T cells in vivo
    Hideki Ito
    Department of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, G 311, 300 Pasteur Dr, Stanford, CA 94305, USA
    J Virol 79:4819-27. 2005
    ....
  101. ncbi Varicella-Zoster virus gene expression in latently infected rat dorsal root ganglia
    P G Kennedy
    Glasgow University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, Scotland, United Kingdom
    Virology 289:218-23. 2001
    ....

Research Grants48

  1. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  2. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
  3. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    ..It may also make it possible to develop a safer and more efficacious vaccine. ..
  4. PEDIATRICS AIDS CLINICAL TRIALS GROUP
    Anne Gershon; Fiscal Year: 2006
    ..We have competent, outstanding staff whose aim is not only to provide compassionate medical care to HIV-infected patients but also to perform meaningful and useful research on prevention and treatment of HIV infection. ..
  5. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
    ..These proposed VZV studies will provide further insight into the multiple functions of gE and the gE:gI complex. ..
  6. ROLE OF VARICELLA ZOSTER VIRUS GLYCOPROTEIN B DURING VIR
    THOMAS HEINEMAN; Fiscal Year: 2003
    ..This research may identify critical viral metabolic pathways and may ultimately lead to the development of new antiviral therapies. ..
  7. EGFP-Tagged VZV for the Study of Neuronal Infection
    THOMAS HEINEMAN; Fiscal Year: 2006
    ..Successful completion of these studies will result in reagents and the development of techniques that will open new avenues of research into the molecular biology of VZV pathogenesis. ..
  8. Cdk inhibitors: novel antivirals for VZV
    Jennifer Moffat; Fiscal Year: 2007
    ..Understanding precisely how cdk inhibitors block VZV growth is the starting point for development of effective antiviral agents. [unreadable] [unreadable]..
  9. Cocaine Dependence: EEG Sleep and Cytokines
    Michael Irwin; Fiscal Year: 2005
    ..abstract_text> ..
  10. Alcoholism: Sleep and Cytokines in African Americans
    Michael Irwin; Fiscal Year: 2005
    ..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
  11. Structure/Function of Varicella Zoster Virus DNA
    William Ruyechan; Fiscal Year: 2007
    ..We will also examine the recently identified interaction between IE63 and the host RNA Polymerase I1. ..
  12. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  13. Herpes Zoster and Medications in the Elderly
    Kenneth Schmader; Fiscal Year: 2005
    ..The award fits into past and future career development by providing a bridge from earlier academic activities to the expansion of mentoring and research skills and to program leadership in geriatrics. ..
  14. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..The study may also provide support for use of the VZV vaccine as a recombinant vector for immunization against other infectious agents, particularly human immunodeficiency virus (HIV). ..
  15. BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGING
    Michael Irwin; Fiscal Year: 2003
    ....
  16. Sleep and Immune Mechanisms in Rheumatoid Arthritis
    Michael Irwin; Fiscal Year: 2009
    ..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
  17. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
    ....
  18. RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVEL
    Michael Irwin; Fiscal Year: 2006
    ..abstract_text> ..
  19. Structural, Functional & Evolutionary Genomics Gordon Conference
    Joel Bader; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. In Vivo Antiviral Activity of Saponins
    MICHAEL RONER; Fiscal Year: 2007
    ..The extract is well suited to such an application as it is pH stable, is already approved as a food additive, is inexpensive, readily available and is soluble in water. [unreadable] [unreadable] [unreadable]..
  21. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Respiratory Viruses and Airflow Obstruction after HCT
    Michael Boeckh; Fiscal Year: 2008
    ..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
  23. Structural models and direct and indirect effects of alcohol use on HIV infection
    Stephen R Cole; Fiscal Year: 2010
    ..Second, it will provide innovations and detailed worked examples in quantitative methods for complex observational data analysis. ..
  24. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  25. Clinical Performance Measures & Outcomes in Adolescents
    Susan Furth; Fiscal Year: 2005
    ..abstract_text> ..
  26. Preclinical Testing of Interleukin-7 in Primates
    Jan Storek; Fiscal Year: 2003
    ..These results will be used for the design of clinical studies. ..
  27. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  28. VACCINATION AGAINST HERPES SIMPLEX VIRUS
    BARRY ROUSE; Fiscal Year: 2004
    ..Our results should be applicable to the future design of vaccines against HSV and may have application to other situations that require immunomodulation. ..
  29. IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS
    BARRY ROUSE; Fiscal Year: 2005
    ..Our experiments may identify better methods of generating protective immunity against HSV. ..
  30. Novel inhibitors of the replication of poxviruses
    Johan Neyts; Fiscal Year: 2004
    ..The final goal of this application is to advance a compound for the treatment of (systemic or cutaneous) poxvirus infections to the initial stages of development, i.e., selecting an IND candidate. ..
  31. CONTROL OF VIRAL RNA SYNTHESIS IN HERPES VIRUS INFECTION
    TIMOTHY OSBORNE; Fiscal Year: 2005
    ..We will also study kinetic modifications of expression of the VP19 capsid protein, the virion trans- activating protein, and the immediate-early ICP 27 promoter. ..
  32. REGULATION OF INFLAMMATORY RESPONSES
    Andreas Reimold; Fiscal Year: 2002
    ..This knowledge will be applied to the HTLV-1-transgenic mouse model of rheumatoid arthritis to assess if a dominant-negative mutant of hXBP-1 reduces joint inflammation. ..
  33. Mapping disease-specific human protein networks
    Joel Bader; Fiscal Year: 2005
    ..Success in Phase I of this project will result in improved methods for mapping disease-relevant human biological networks. Success in Phase II will result in targets for therapeutic intervention. ..
  34. The Response to Influenza: Aging and Vaccine Efficacy
    Yuping Deng; Fiscal Year: 2005
    ..Information from this study will also have great implication on strategy for protecting elderly population against other bioterrorist attack. ..
  35. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..This experience will give Dr. Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  36. T CELL RECONSTITUTION AFTER STEM CELL AUTOGRAFTING
    Jan Storek; Fiscal Year: 2003
    ..This will give impetus for developing strategies to enable older patients to generate T cells from hemopoietic progenitors, e.g., using thymopoietic cytokines or thymus grafting. ..
  37. Docosanol and Acyclovir for Treating Genital Herpes
    LAURA POPE; Fiscal Year: 2003
    ..If proven safe and effective, it would provide a new single agent treatment as well as allow concurrent use with acyclovir. PROPOSED COMMERCIAL APPLICATION: Topical treatment for recurrent genital herpes infections. ..
  38. ASSESSING PATIENT OUTCOMES IN PEDIATRIC ESRD
    Susan Furth; Fiscal Year: 2003
    ..Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  39. Structural Models to Bridge Observational and Randomized Evidence: HAART and AIDS
    Stephen Cole; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
  41. DNA Microarrays for Neurotropic Human Herpesviruses
    TIMOTHY OSBORNE; Fiscal Year: 2004
    ..4. Apply these methods towards design of DNA microarrays specific for other members of the human alpha herpesvirus group. ..
  42. Compressed Autoantibody Induction Heralding Autoimmunity
    Andreas Reimold; Fiscal Year: 2006
    ..The gene expression signatures of autoantibody induction that emerges from this study will characterize the earliest stages of autoimmune disease induction. ..
  43. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  44. Comparative systematic genetics for cardiovascular disease gene identification
    Joel Bader; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. Molecular Epidemiology of Fatal Prostate Cancer
    Sheila Weinmann; Fiscal Year: 2006
    ..The case-control study design will provide maximum statistical power for analysis of these relationships, particularly in the important African-American subgroup. ..
  46. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..abstract_text> ..
  47. IMMUNOBIOLOGY OF AGING
    MARC WEKSLER; Fiscal Year: 2003
    ..The influence of anti-influenza T cell clones on the immune system of young and old mice as well as the function of the anti- influenza TCR T cell clone in young and old mice will be studied. ..