simplexvirus

Summary

Summary: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.

Top Publications

  1. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
  2. pmc Herpesvirus entry: an update
    Patricia G Spear
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:10179-85. 2003
  3. pmc Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures
    Kerstin Radtke
    Institute of Virology, Hannover Medical School, Hannover, Germany
    PLoS Pathog 6:e1000991. 2010
  4. pmc Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Kamal M Khanna
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 18:593-603. 2003
  5. pmc The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1
    Brandon J Placek
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennysylvania 19104, USA
    J Virol 83:1416-21. 2009
  6. pmc Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 84:12292-9. 2010
  7. pmc The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection
    Aarthi Narayanan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4 131, 4 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:10835-40. 2007
  8. pmc Initial interaction of herpes simplex virus with cells is binding to heparan sulfate
    D WuDunn
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637
    J Virol 63:52-8. 1989
  9. pmc Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, and Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 104:18718-23. 2007
  10. ncbi Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport
    Mark W Douglas
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead 2145, New South Wales, Australia
    J Biol Chem 279:28522-30. 2004

Research Grants

Detail Information

Publications252 found, 100 shown here

  1. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
    ..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
  2. pmc Herpesvirus entry: an update
    Patricia G Spear
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:10179-85. 2003
  3. pmc Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures
    Kerstin Radtke
    Institute of Virology, Hannover Medical School, Hannover, Germany
    PLoS Pathog 6:e1000991. 2010
    ..Thus, these associated motors either engage in a tug-of-war or their activities are coordinately regulated to achieve net transport either to the nucleus during cell entry or to cytoplasmic membranes for envelopment during assembly...
  4. pmc Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Kamal M Khanna
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 18:593-603. 2003
    ..We conclude that CD8(+) T cells provide active surveillance of HSV-1 gene expression in latently infected sensory neurons...
  5. pmc The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1
    Brandon J Placek
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennysylvania 19104, USA
    J Virol 83:1416-21. 2009
    ..These findings show that incorporation of H3.3 facilitates transcription, and they provide new evidence for a regulatory role of chromatin composition during HSV-1 acute infection...
  6. pmc Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 84:12292-9. 2010
    ..The third step may be common to other herpesviruses...
  7. pmc The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection
    Aarthi Narayanan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4 131, 4 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:10835-40. 2007
    ..These studies also contribute to the model whereby the induced nuclear transport of HCF-1 in sensory neurons may be critical to the reactivation of latent herpesviruses by promoting the activation of chromatin modifications...
  8. pmc Initial interaction of herpes simplex virus with cells is binding to heparan sulfate
    D WuDunn
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637
    J Virol 63:52-8. 1989
    ..Consistent with their broad host ranges, the two HSV serotypes use as primary receptors ubiquitous cell surface components known to participate in interactions with the extracellular matrix and with other cell surfaces...
  9. pmc Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, and Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 104:18718-23. 2007
    ..Thus, when gD binds its receptor, the core fusion machinery is triggered to form a multiprotein complex as a step in fusion and possibly virus entry...
  10. ncbi Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport
    Mark W Douglas
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead 2145, New South Wales, Australia
    J Biol Chem 279:28522-30. 2004
    ..We propose that VP26 mediates binding of incoming herpes simplex virus capsids to cytoplasmic dynein during cellular infection, through interactions with dynein light chains...
  11. pmc Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM
    James M Markert
    Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 3410, USA
    Mol Ther 17:199-207. 2009
    ..Evidence of viral replication was demonstrated. G207 appears safe for multiple dose delivery, including direct inoculation into the brain surrounding tumor resection cavity...
  12. ncbi Chromatin control of herpes simplex virus lytic and latent infection
    David M Knipe
    Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Microbiol 6:211-21. 2008
    ....
  13. ncbi The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified
    S M Freeman
    Clinical Immunology Unit, University of Rochester Medical School, New York 14642
    Cancer Res 53:5274-83. 1993
    ..p. tumor burden by injecting HSV-TK-positive cells and GCV. These results suggest that genetic modification of tumor cells may be useful for developing cancer therapies...
  14. pmc Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer
    P Castelo-Branco
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Gene Ther 17:805-10. 2010
    ..These data lend support to the concept of combining oncolytic and immunogenic therapies as a way to improve therapy of metastatic prostate cancer...
  15. ncbi Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic
    Nikiforos Kapranos
    Division of Molecular Pathology, Department of Pathology, Amalia Fleming Hospital, Athens, Greece
    Fertil Steril 79:1566-70. 2003
    ..To investigate the prevalence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in the semen of men with fertility problems...
  16. pmc Phase I/II study of oncolytic herpes simplex virus NV1020 in patients with extensively pretreated refractory colorectal cancer metastatic to the liver
    Sunil K Geevarghese
    Department of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University, Nashville, TN 37232, USA
    Hum Gene Ther 21:1119-28. 2010
    ..2%. We conclude that NV1020 stabilizes liver metastases with minimal toxicity in mCRC. It may resensitize metastases to salvage chemotherapy and extend overall survival. A randomized phase II/III trial now appears justified...
  17. pmc Herpes simplex virus glycoproteins H/L bind to cells independently of {alpha}V{beta}3 integrin and inhibit virus entry, and their constitutive expression restricts infection
    Tatiana Gianni
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy
    J Virol 84:4013-25. 2010
    ....
  18. ncbi Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
    Peter C Ruokonen
    Augenklinik Charité Universitätsmedizin Berlin CVK Germany, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:565-71. 2010
    ..Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection...
  19. ncbi Epstein-Barr virus in pediatric multiple sclerosis
    Suad Alotaibi
    Department of Pediatrics Neurology, Al Sabah Hospital, Shuwaikh, Kuwait
    JAMA 291:1875-9. 2004
    ..Infection with common viruses, particularly Epstein-Barr virus (EBV), has been postulated to contribute to the pathobiology of multiple sclerosis (MS). Detailed virological studies in pediatric MS have not been previously reported...
  20. pmc Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex
    Haidong Gu
    Marjorie B Kovler Viral Oncology Laboratories, University of Chicago, 910 East 58th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:17134-9. 2007
    ..We conclude that CoREST(146-482) functionally replaced ICP0 and that, by extension, ICP0 acts to block the silencing of viral DNA by displacing HDAC1/2 from the CoREST-REST complex...
  21. pmc Resolving the assembly state of herpes simplex virus during axon transport by live-cell imaging
    Sarah E Antinone
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA
    J Virol 84:13019-30. 2010
    ....
  22. ncbi Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
    G Karupiah
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:1445-8. 1993
    ..In mice, an inhibitor of NO synthase converted resolving ectromelia virus infection into fulminant mousepox. Thus, induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-gamma...
  23. pmc Recent progress in herpes simplex virus immunobiology and vaccine research
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Microbiol Rev 16:96-113. 2003
    ..HSV vaccines have also been evaluated for the immunotherapy of established HSV infection...
  24. pmc Herpes simplex virus gE/gI sorts nascent virions to epithelial cell junctions, promoting virus spread
    D C Johnson
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Virol 75:821-33. 2001
    ..Delivery of virus particles to cell junctions would be expected to enhance virus spread and enable viruses to avoid host immune defenses...
  25. pmc Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step
    Mark G Delboy
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0678, USA
    J Virol 82:3381-90. 2008
    ..We propose that proteasomal degradation of virion and/or host proteins is required for efficient delivery of incoming HSV capsids to the nucleus...
  26. ncbi Intracarotid delivery of oncolytic HSV vector G47Delta to metastatic breast cancer in the brain
    R Liu
    Molecular Neurosurgery Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Gene Ther 12:647-54. 2005
    ..This is the first demonstration of intracarotid arterial delivery of oncolytic HSV vectors and antitumor efficacy in a mouse model and opens the door to the use of mouse syngenic tumor models and transgenic/knockout animals...
  27. ncbi The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells
    G Campadelli-Fiume
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Rev Med Virol 10:305-19. 2000
    ..This provides the first example of a mediator of HSV entry independent of a detectable interaction with gD...
  28. pmc Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein
    Elisa Avitabile
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    J Virol 81:11532-7. 2007
    ..The in situ assay provides evidence that gD interacts with gH and gB independently of each other and supports a model whereby gH and gB in complex exert their activities to gD...
  29. ncbi Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck
    Kevin J Harrington
    Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
    Clin Cancer Res 16:4005-15. 2010
    ....
  30. pmc Herpesvirus transport to the nervous system and back again
    Gregory Smith
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Microbiol 66:153-76. 2012
    ..This remarkable cycle of infection is the topic of this review. In addition, some of the distinguishing hallmarks of the infections caused by these viruses are evaluated in terms of their underlying similarities...
  31. ncbi A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells
    B Huard
    The R W Johnson Pharmaceutical Research Institute San Diego, USA
    Eur J Immunol 30:509-15. 2000
    ..These results show for the first time that MHC class I down-regulation could render cells infected with herpes viruses susceptible to NK cell killing, thus demonstrating a role for KIR in the recognition of virally infected cells...
  32. ncbi Antigen microarrays for serodiagnosis of infectious diseases
    Letizia Mezzasoma
    Department of Biology, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
    Clin Chem 48:121-30. 2002
    ....
  33. pmc Herpes simplex virus dances with amyloid precursor protein while exiting the cell
    Shi Bin Cheng
    Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 6:e17966. 2011
    ..Such dynamic interactions between APP and HSV1 suggest a mechanistic basis for the observed clinical relationship between HSV1 seropositivity and risk of Alzheimer's disease...
  34. ncbi The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein
    A C Wilson
    Cold Spring Harbor Laboratory, New York 11724
    Cell 74:115-25. 1993
    ..When expressed in human cells, this large open reading frame encodes both the 300 kd and smaller HCF polypeptides, indicating that the smaller polypeptides arise by processing of the 300 kd protein...
  35. ncbi The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells
    Q Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People s Republic of China
    Cancer Gene Ther 17:192-202. 2010
    ..In conclusion, Cx43 combined with HSV-TK/GCV gene therapy using BMSCs as vehicles was highly effective in a rat glioma model and therefore hold great potential as a novel approach for the gene therapy of human malignant gliomas...
  36. pmc Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain
    Tatiana Gianni
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum, University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy
    J Biol Chem 284:17370-82. 2009
    ..The results indicate that gD carries composite-independent binding sites for gB and gH/gL, both of which are partly located in the profusion domain...
  37. ncbi Herpes simplex virus capsid assembly and DNA packaging: a present and future antiviral drug target
    Joel D Baines
    Department of Microbiology and Immunology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Trends Microbiol 19:606-13. 2011
    ..The goal of this review is to outline these intranuclear assembly steps and illustrate potential and existing antiviral strategies that exploit them...
  38. pmc Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency
    Eain Murphy
    Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 105:5453-8. 2008
    ..We propose that herpesviruses use microRNA-mediated suppression of immediate-early genes as part of their strategy to enter and maintain latency...
  39. ncbi Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis
    Jolanda D F de Groot-Mijnes
    Department of Virology, Eijkman Winkler Center, and F C Donders Institute of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ophthalmol 141:313-8. 2006
    ..To determine the relative contribution of the analysis of intraocular antibody production and the polymerase chain reaction (PCR) in aqueous humor (AH) to the diagnosis of infectious uveitis...
  40. ncbi Influence of the bystander effect on HSV-tk/GCV gene therapy. A review
    Ingrid J van Dillen
    Department of Medical Oncology, Groningen University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Gene Ther 2:307-22. 2002
    ..In addition, theories concerning its mechanisms and possible approaches to augment this effect are discussed. Finally, we give an overview of clinical trials using suicide gene therapy...
  41. pmc Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter
    M Ahn
    Department of Urology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer Gene Ther 16:73-82. 2009
    ..Our results demonstrate the therapeutic potential of specific-oncolysis and suicide gene therapy for AI-PSA/PSMA-positive prostate cancer gene therapy...
  42. pmc Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD
    Elisa Avitabile
    Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    J Virol 83:10752-60. 2009
    ....
  43. ncbi Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood
    Laurent Abel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM National Institute of Health and Medical Research, Paris, France
    J Pediatr 157:623-9, 629.e1. 2010
    ..To test the hypothesis that predisposition to childhood herpes simplex virus (HSV) type 1 encephalitis (HSE) may be determined in part by human genetic factors...
  44. ncbi Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine
    Wenhong Ren
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:6645-51. 2004
    ..Our findings may have broad relevance to the use of the in vivo HSP/suicide gene tumor vaccine in therapy for human solid tumors...
  45. ncbi Marine organisms as a therapeutic source against herpes simplex virus infection
    Thanh Sang Vo
    Department of Chemistry, Pukyong National University, Busan, Republic of Korea
    Eur J Pharm Sci 44:11-20. 2011
    ..This contribution presents an overview of potential anti-HSV agents derived from marine organisms and their promising application in HSV therapy...
  46. pmc Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Virol 84:3825-34. 2010
    ..Upon triggering by gD, gB fusion loops are inserted into target lipid membranes. gB then interacts with gH/gL, and this interaction is eventually followed by fusion...
  47. ncbi Enhanced efficacy of transcriptionally targeted suicide gene/prodrug therapy for thyroid carcinoma with the Cre-loxP system
    Y Nagayama
    Department of Pharmacology 1, Nagasaki University School of Medicine, Japan
    Cancer Res 59:3049-52. 1999
    ..These data indicate the usefulness of the Cre-loxP system to enhance the activity of a tissue (or tumor)-specific promoter in transcriptionally targeted cancer gene therapy...
  48. ncbi Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades
    C J Carter
    Neurochem Int 52:920-34. 2008
    ....
  49. ncbi E-cadherin contributes to the bystander effect of TK/GCV suicide therapy and enhances its antitumoral activity in pancreatic cancer models
    L García-Rodriguez
    Programa Gens i Malaltia, Centre de Regulacio Genomica, Parc de Recerca Biomedica de Barcelona, UPF, Barcelona, Spain
    Gene Ther 18:73-81. 2011
    ..Thus, we propose that by restoring E-cadherin in pancreatic tumor cells we will improve TK/GCV therapy, both by enhancing the bystander effect and by facilitating the induction of apoptosis...
  50. ncbi Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application
    C Fillat
    Programa Gens i Malaltia, Centre de Regulacio Genomica, Barcelona, Spain
    Curr Gene Ther 3:13-26. 2003
    ..The present review describes the current state of preclinical research and summarizes the results of the clinical trials undertaken...
  51. pmc Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain
    Russell J Diefenbach
    Centre for Virus Research and Electron Microscopy Unit, The Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales, Australia
    J Virol 76:3282-91. 2002
    ..These observations suggest a major role for the uKHC-US11 interaction in anterograde transport of unenveloped HSV nucleocapsids in axons...
  52. ncbi The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins
    June Harland
    Glasgow University, Neurovirology Research Laboratories, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    J Neurovirol 9:477-88. 2003
    ..5 in HSV replication are understood. The authors propose that in nondividing cells, ICP34.5 is required to switch PCNA from repair to replication mode, a prerequisite for the initiation of HSV replication...
  53. pmc Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on herpesvirus entry mediator HveA (HVEM)
    Sarah A Connolly
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:10894-904. 2002
    ..This structure-based dissection of the gD-HveA binding site highlights the contribution of key residues within HveA to gD binding and HSV entry and defines a target region for the design of small-molecule inhibitors...
  54. ncbi Oncolytic herpes simplex virus vectors for cancer virotherapy
    Susan Varghese
    Molecular Neurosurgery Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Gene Ther 9:967-78. 2002
    ..have been constructed to maximize tumor destruction through multimodal therapeutic mechanisms. Further advances in virus delivery and tumor specificity should improve the likelihood for successful translation to the clinic...
  55. ncbi Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase
    Yoshiyuki Hattori
    Institute of Medicinal Chemistry, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Cancer Gene Ther 12:796-809. 2005
    ..These findings suggested that the NP-F is a potential target vector in prostate and nasopharyngeal cancer for suicide gene therapy...
  56. ncbi Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits
    F Malecaze
    CJF INSERM 9510, CHU Purpan, Toulouse, France
    Hum Gene Ther 10:2365-72. 1999
    ..001). These results suggest that adenoviral vector-mediated transfer of HSV-tk into the proliferating lens epithelial cells is feasible and may provide a novel therapeutic strategy for PCO...
  57. ncbi Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Université de Paris Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
    Am J Respir Crit Care Med 175:935-42. 2007
    ....
  58. ncbi Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate
    P E Pertel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois, 60611, USA
    Virology 279:313-24. 2001
    ..Overall, the viral and cellular determinants of HSV-1-induced cell fusion are similar to those for viral entry, except that HSV-1 entry is significantly enhanced by binding of virus to cell surface heparan sulfate...
  59. pmc Characterization of herpes simplex virus-containing organelles by subcellular fractionation: role for organelle acidification in assembly of infectious particles
    C A Harley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Virol 75:1236-51. 2001
    ..We conclude that the organelles of the TGN/endocytic network play a key role in the assembly and trafficking of infectious HSV...
  60. pmc Oncolytic herpes simplex virus vectors and chemotherapy: are combinatorial strategies more effective for cancer?
    Ryuichi Kanai
    Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Future Oncol 6:619-34. 2010
    ..In this article, we will discuss the recent progress of these combinatorial strategies between virotherapy and chemotherapy and future directions...
  61. ncbi Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene
    Marjolijn M van der Eb
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    J Gene Med 5:1018-27. 2003
    ....
  62. pmc Herpes simplex virus oncolytic therapy for pediatric malignancies
    Gregory K Friedman
    Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
    Mol Ther 17:1125-35. 2009
    ....
  63. ncbi Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector
    Toshihiko Kuroda
    Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 66:10127-35. 2006
    ..Our results suggest that a transcriptionally regulated oncolytic herpes vector targeting beta-catenin/Tcf signal is very efficacious against CRC tumors carrying an APC gene mutation between the first and second 20-amino-acid repeats...
  64. pmc Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry
    Claude Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
    EMBO J 24:4144-53. 2005
    ..We propose that a controlled displacement of the gD C-terminus upon receptor binding is an essential feature of HSV entry, ensuring the timely activation of membrane fusion...
  65. ncbi Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21
    Naoyuki Hanari
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260 8670, Japan
    Anticancer Res 27:2305-10. 2007
    ..We examined the effect of the combination of herpes simplex virus type1-thymidine kinase (HSV-TK)-suicide gene therapy and interleukin-21 (IL-21) immune gene therapy...
  66. ncbi A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
    Jennifer C C Hu
    Department of Cancer Medicine, Imperial College School of Medicine, Royal Marsden Hospital, London, UK
    Clin Cancer Res 12:6737-47. 2006
    ....
  67. ncbi Herpes simplex virus gene products: the accessories reflect her lifestyle well
    Yukihiro Nishiyama
    Department of Virology, Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    Rev Med Virol 14:33-46. 2004
    ..Finally, specific HSV gene products are being explored as therapeutic agents...
  68. pmc Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons
    Aleksandra Snyder
    Department of Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Virol 82:10613-24. 2008
    ..Our observations suggest that gE/gI and US9 function in the neuron cell body to promote the loading of capsids and glycoprotein-containing vesicles onto microtubule motors that ferry HSV structural components toward axon tips...
  69. pmc A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells
    Ryuichi Kanai
    Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 17:3686-96. 2011
    ..One approach to enhance oHSV efficacy is by combination with other therapeutic modalities...
  70. ncbi Accuracy of clinical diagnosis of genital ulcer disease
    Y Dangor
    Emergent Pathogen Research Unit, South African Medical Research Council, School of Pathology, University of the Witwatersrand, Johannesburg
    Sex Transm Dis 17:184-9. 1990
    ..Adequate laboratory facilities are indispensible for the establishment of an accurate etiologic diagnosis of genital ulcer disease and thus the institution of appropriate antimicrobial therapy...
  71. ncbi Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: association with human immunodeficiency virus infection
    S A Morse
    Division of AIDS, Sexually Transmitted Diseases and Tuberculosis Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 175:583-9. 1997
    ..The sensitivities of H. ducreyi and HSV cultures were 75% and 60%, respectively. HSV, detected in 47% of specimens from HIV-infected versus 16% from HIV-uninfected patients (P < .001), may be emerging as a more frequent cause of GUD...
  72. ncbi Genital ulcer disease in India: etiologies and performance of current syndrome guidelines
    Parimi Prabhakar
    India HIV AIDS Alliance, Hyderabad, India
    Sex Transm Dis 39:906-10. 2012
    ....
  73. ncbi Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
    ..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens...
  74. ncbi In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine
    Paul D Boucher
    Department of Pharmacology, University of Michigan Medical Center, 1310 East Catherine, Ann Arbor, MI 48109, USA
    Mol Ther 12:1064-71. 2005
    ..Furthermore, dFdCyd alone or in combination with GCV produced no evidence of toxicity or significant weight loss. These data suggest that dFdCyd may improve the clinical efficacy of HSV-TK/GCV gene therapies...
  75. ncbi Factors associated with delay to acyclovir administration in 184 patients with herpes simplex virus encephalitis
    J Poissy
    Service Universitaire des Maladies Infectieuses et du Voyageur, Tourcoing, France
    Clin Microbiol Infect 15:560-4. 2009
    ..8%), and three in six (3.3%). Patients with HSE often present with severe underlying disease, chronic alcohol abuse, or atypical CSF findings, and such factors should not be allowed to delay diagnosis and administration of acyclovir...
  76. ncbi Combination of a fusogenic glycoprotein, prodrug activation, and oncolytic herpes simplex virus for enhanced local tumor control
    Guy R Simpson
    BioVex Inc, Woburn, Massachusetts 01801, USA
    Cancer Res 66:4835-42. 2006
    ..It is intended to enter the GALV/Fcy::Fur expressing virus into clinical development for the treatment of tumor types, such as pancreatic or lung cancer, where local control would be anticipated to be clinically advantageous...
  77. ncbi Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 190:494-8. 2004
    ..It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection...
  78. pmc Temporal association of the herpes simplex virus genome with histone proteins during a lytic infection
    Jaewook Oh
    Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 82:3530-7. 2008
    ..However, after viral DNA replication initiates, histones appear not to associate with newly synthesized viral genomes...
  79. ncbi Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models
    K Terada
    Molecular Neuro oncology Laboratories, Neurosurgical Service, Massachusetts General Hospital, Charlestown, USA
    Gene Ther 13:705-14. 2006
    ..The HSVQuik system, together with luciferase-labeled tumor models, should expedite the process of generating and evaluating oncolytic HSV vectors for cancer gene therapy applications...
  80. ncbi Progress and problems with the use of viral vectors for gene therapy
    Clare E Thomas
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Rev Genet 4:346-58. 2003
    ..With the development of a leukaemia-like syndrome in two of the small number of patients that have been cured of a disease by gene therapy, it is timely to contemplate how far this technology has come, and how far it still has to go...
  81. ncbi Investigation of vesicular rashes for HSV and VZV by PCR
    G Beards
    Public Health Laboratory, Birmingham Heartlands Hospital, United Kingdom
    J Med Virol 54:155-7. 1998
    ..For varicella zoster virus, the sensitivities of virus isolation and electron microscopy were 47% and 60%. These data illustrate the advantage of rapid PCR diagnosis of herpes simplex virus and varicella zoster virus in vesicle fluids...
  82. pmc Reconstitution of herpes simplex virus microtubule-dependent trafficking in vitro
    Grace E Lee
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Virol 80:4264-75. 2006
    ..This simple, minimal reconstitution of microtubule-mediated anterograde traffic should facilitate and complement molecular analysis of HSV egress in vivo...
  83. ncbi Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy
    Yasutomo Nasu
    Department of Urology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    Mol Ther 15:834-40. 2007
    ..This study confirmed the safety profile and possibility of clinical response at the surrogate marker level in a clinical trial of HSV-tk gene therapy for hormone-refractory prostate cancer...
  84. ncbi Therapeutic gene transfer to the nervous system using viral vectors
    Joseph C Glorioso
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurovirol 9:165-72. 2003
    ..The results of the first human gene therapy trials for neurologic disease, which are just now beginning, will be crucial in defining the next step in the development of this therapy...
  85. ncbi Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model
    A S Majumdar
    Department of Oncology, Rhône Poulenc Rorer Gencell, Discovery Research, Hayward, California 94545, USA
    Cancer Gene Ther 7:1086-99. 2000
    ..Thus, the overall data presented here demonstrate that TK gene therapy in combination with GM-CSF and IL-2 gene-mediated immunotherapy strategies have important implications in the treatment of breast cancer...
  86. ncbi Medical application of herpes simplex virus
    Daisuke Watanabe
    Department of Dermatology, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Dermatol Sci 57:75-82. 2010
    ..These major HSV-derived vectors include: (i) amplicons for gene delivery vectors; (ii) replication-defective HSV recombinants for vaccine vectors; (iii) replication-attenuated HSV recombinants for oncolytic virotherapy...
  87. ncbi Comparison of six nucleic acid extraction methods for detection of viral DNA or RNA sequences in four different non-serum specimen types
    T Kok
    Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Clin Virol 16:59-63. 2000
    ..However, the heterogeneous nature of non-serum samples may contribute to variations in the yields of viral nucleic acids with different extraction methods and specimen types...
  88. ncbi Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models
    Kenji Nakano
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gene Med 7:638-48. 2005
    ..The goals of the current study were to examine the performance of combination treatments for peritoneal disseminated cancers and to explore the mechanism of effective combinations...
  89. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    ..This study illustrates the value of mutant mice for understanding receptor contributions to disease caused by a human virus...
  90. ncbi Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer
    O Greco
    Department of Radiation Oncology, Wayne State University and Karmanos Cancer Institute, Hudson Webber CRC, Detroit, MI, USA
    Gene Ther 13:206-15. 2006
    ..In conclusion, hypoxia- and radiation-activated 'molecular switch' vectors represent a promising strategy for both targeted and effective gene therapy of solid tumors...
  91. ncbi Focal adhesion kinase plays a pivotal role in herpes simplex virus entry
    Natalia Cheshenko
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:31116-25. 2005
    ..Together, these results support a novel model for invasion that implicates FAK phosphorylation as important for delivery of viral capsids to the nuclear pore...
  92. ncbi High therapeutic potential for systemic delivery of a liposome-conjugated herpes simplex virus
    Toshio Shikano
    Department of Surgery II, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Japan
    Curr Cancer Drug Targets 11:111-22. 2011
    ..However, systemic intravascular injections are limited by the humoral immune response, which dramatically decreases the level of infection. To overcome this limitation, we encapsulated the oncolytic virus in liposomes...
  93. pmc Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates
    Olivier Menzel
    Research Laboratory of Pediatric Surgery, Department of Microbiology and Molecular Medicine, University of Geneva Medical School, Geneva, Switzerland
    Mol Ther 17:1754-60. 2009
    ..The HSV-TK/valganciclovir suicide strategy can increase the biosafety of liver gene therapy protocols by safely and completely ablating transduced hepatocytes on demand...
  94. ncbi The herpes simplex virus VP16-induced complex: the makings of a regulatory switch
    Joanna Wysocka
    Cold Spring Harbor Laboratory, NY 11724, USA
    Trends Biochem Sci 28:294-304. 2003
    ..The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host...
  95. ncbi Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16
    M Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA
    Oncogene 27:4249-54. 2008
    ..These approaches provide in vitro and in vivo evidence that ICP6-negative HSVs are 'molecularly targeted,' because they replicate in quiescent tumor cells carrying specific oncogene deletions, independent of cell cycle status...
  96. ncbi Transport and egress of herpes simplex virus in neurons
    Russell J Diefenbach
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, Westmead, NSW 2145, Australia
    Rev Med Virol 18:35-51. 2008
    ..Current hypotheses suggest that unenveloped HSV capsids complete assembly in the axonal growth cones and varicosities, whereas with PrV unenveloped capsids are only found travelling in a retrograde direction...
  97. ncbi A strict-late viral promoter is a strong tumor-specific promoter in the context of an oncolytic herpes simplex virus
    X Fu
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Ther 10:1458-64. 2003
    ..These results suggest that delivery of therapeutic genes driven by UL38p through an oncolytic HSV may be an effective approach to gene therapy for malignant diseases...
  98. pmc A herpes simplex virus gD-YFP fusion glycoprotein is transported separately from viral capsids in neuronal axons
    Aleksandra Snyder
    Department of Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    J Virol 81:8337-40. 2007
    ..Anti-gD antibodies colocalized with gD-YFP, indicating that gD-YFP behaves like wild-type HSV gD...
  99. ncbi An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice
    Yasuhiro Terazaki
    Department of Surgery, Kurume University School of Medicine, Japan
    Hepatology 37:155-63. 2003
    ..The present results, which contradict those of previous studies, alert researchers about possible problems with ongoing and future clinical trials that lack this concept...
  100. pmc Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease
    Prasanna Satpute-Krishnan
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 2:305-18. 2003
    ..This work links fast anterograde transport of the common pathogen, HSV, with the neurodegenerative Alzheimer's disease. This novel connection should prompt new ideas for treatment and prevention strategies...
  101. ncbi [Effects of adenovirus-mediated HSV-tk/GCV system on lens epithelium]
    Bing Wang
    Department of Ophthalmology, Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Zhonghua Yan Ke Za Zhi 38:618-22. 2002
    ..To investigate the efficiency of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) suicide gene therapy system on calf lens epithelial cells and analyze the mechanism of cell death...

Research Grants74

  1. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..The goal of this research is to characterize the latency associated transcript gene (LAT) region and investigate the role of LAT during latency in a natural host model system. . ..
  2. HERPES SIMPLEX VIRUS GENE REGULATION
    ROZANNE SANDRI GOLDIN; Fiscal Year: 2001
    ....
  3. Domain structure and interactions of HSV-1 ICP27
    ROZANNE SANDRI GOLDIN; Fiscal Year: 2008
    ..abstract_text> ..
  4. Functional analysis of HSV-2 tegument proteins in mice
    LYNDA MORRISON; Fiscal Year: 2008
    ..These investigations will improve our understanding of the roles of the UL13 and vhs enzymes in HSV-2 pathogenesis. ..
  5. Vaccine to Prevent HSV-induced keratitis
    LYNDA MORRISON; Fiscal Year: 2006
    ..Aim 3: We will determine immunogenicity, and prophylactic and therapeutic efficacy of ICP8-/vhs- /B7+ HSV BAC as a DNA vaccine versus ICP8-/vhs- /B7+ virus vaccine. [unreadable] [unreadable]..
  6. Substrate recognition motif of the HSV-2 UL 13 kinase
    LYNDA MORRISON; Fiscal Year: 2006
    ..Our long-range goal is to use the novel viral targets identified through application of the UL13 recognition motif to elucidate the mechanisms by which UL13 regulates viral replication and pathology. [unreadable] [unreadable]..
  7. MECHANISMS OF MUCOSAL IMMUNITY TO HERPES SIMPLEX VIRUS
    LYNDA MORRISON; Fiscal Year: 2002
    ..This information will facilitate developent of immunization strategies against HSV and possibly other pathogens of the genital tract. ..
  8. Herpes simplex virus receptors and signal transduction
    PATRICIA SPEAR; Fiscal Year: 2003
    ..The studies described in this proposal are distinct from those supported by the parent grant but address questions that arise from findings made in the parent project. ..
  9. In Vivo Genetic Manipulation of Neuronal Excitability
    David Yeomans; Fiscal Year: 2004
    ..7 channels in chronic pain patients, providing a long-term genetic therapy for their pain. ..
  10. INTL CONG OF VIROLOGY, SAN FRANCISCO, ASV TRAVEL REQUEST
    PATRICIA SPEAR; Fiscal Year: 2005
    ....
  11. Herpesviruses in Vestibular Neuritis
    JEFFREY VRABEC; Fiscal Year: 2003
    ..This information can help determine why some individuals with latent virus in the vestibular ganglion develop clinical symptoms due to reactivation and some do not. ..
  12. ENTRY OF HERPES SIMPLEX VIRUS INTO CELLS
    PATRICIA SPEAR; Fiscal Year: 2008
    ..abstract_text> ..
  13. NOCICEPTOR SELECTIVE ANALGESIA
    David Yeomans; Fiscal Year: 2001
    ....
  14. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    ..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain. ..
  15. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009
    ..These mechanistic studies, in turn, can lead to the determination of new targets for pharmacdceutical development, as well as for gene therapy approaches. ..
  16. Opportunistic Oral HSV-- Mechanisms of Reactivation
    Craig Miller; Fiscal Year: 2006
    ....
  17. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  18. Enzymatic Differences Among Hepatitis C Virus Genotypes
    David Frick; Fiscal Year: 2007
    ..abstract_text> ..
  19. Gene and Cell Therapy of Duchenne Muscular Dystrophy
    Joseph Glorioso; Fiscal Year: 2008
    ..We believe this to be a timely and highly innovative proposal which is likely to provide new armroaches to the treatment of muscular dvstrophv. ..
  20. Retargeting HSV-1 Vectors to Motor Neurons
    Joseph Glorioso; Fiscal Year: 2005
    ..The soluble HveC adapter will be expected to block gD binding to cellular HveC while directly or indirectly re-targeting the virus to TTx receptors. ..
  21. Glioma Therapy Using Targeted Oncolytic HSV Vectors
    Joseph C Glorioso; Fiscal Year: 2010
    ..abstract_text> ..
  22. A High-Throughput Screen to Identify Small Molecule Compounds That Augment
    Brent Passer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Repression of Oral Virus by Interferon & Nuclear Bodies
    Jerry Taylor; Fiscal Year: 2004
    ..This understanding should allow the development of strategies for treatment of secondary viral infections in the oral cavity of HIV-infected individuals that enhance or mimic these repressive activities. ..
  24. MUTATIONAL MECHANISMS OF REPETITIVE DNA IN HUMAN CELLS
    Kristin Eckert; Fiscal Year: 2001
    ..Our long-term research objective is to test the hypothesis that mutations in repetitive DNA provide an important source of genotypic variation that drives neoplastic progression. ..
  25. Innate Corneal Cell Immunity to Virus Infection
    Jerry Taylor; Fiscal Year: 2004
    ..This knowledge may be utilized to enhance this innate antiviral response and thereby limit initial and recurrent viral infections in the eye. ..
  26. TRIMODAL GENE THERAPY FOR PROSTATE CANCER
    SVEND FREYTAG; Fiscal Year: 2003
    ....
  27. Hepatitis C VIrus NS3 Helicase Inhibitor Discovery
    David Frick; Fiscal Year: 2008
    ..The goal here is to find chemicals that prevent the virus from replicating in human cells. [unreadable] [unreadable] [unreadable]..
  28. Interactions of herpes simplex virus with nectin-1 at cell junctions
    Claude Krummenacher; Fiscal Year: 2008
    ..By identifying new requirements for virus entry in the host, this study will provide targets for novel therapeutic approaches to interfere with this process. [unreadable] [unreadable] [unreadable]..
  29. HSV GENE VECTORS FOR TREATMENT OF ARTHRITIS
    Joseph Glorioso; Fiscal Year: 2001
    ....
  30. DNA replication, DNA repair and microsatellite stability
    Kristin Eckert; Fiscal Year: 2009
    ..Microsatellite allele lengths can directly affect gene expression. As microsatellites are polymorphic in human populations, this effect on gene regulation may be an important factor contributing to individual cancer risk. ..
  31. HCMV US2 & US11 Inhibition of MHC Class II Presentation
    David Johnson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Enhancing the Potency of Viral Vectors with C3d
    GRIFFITH PARKS; Fiscal Year: 2006
    ..At the conclusion of these studies, we will have developed a powerful new class of viral vectors to elicit a more rapid and potent antigen-specific antibody response in the respiratory tract. ..
  33. Tolerated xenografts using virus stealth technology
    MARK CREW; Fiscal Year: 2003
    ..Moreover, the proposed exploitation of viral stealth technology could be readily adopted for allotransplants especially those involving allogeneic stem cells. ..
  34. T CELL RECONSTITUTION AFTER STEM CELL AUTOGRAFTING
    Jan Storek; Fiscal Year: 2003
    ..This will give impetus for developing strategies to enable older patients to generate T cells from hemopoietic progenitors, e.g., using thymopoietic cytokines or thymus grafting. ..
  35. Angiogenic Enhancement of Dopamine Neuron Grafts
    Caryl Sortwell; Fiscal Year: 2003
    ..This strategy will be evaluated using primary mesencephalic tissue. However, results from these studies will be applicable to alternative sources of DA neurons, including stem- and progenitor-derived cells. ..
  36. Macaque Model and Gene Expression Profiling of SARS
    Michael Katze; Fiscal Year: 2009
    ..Such knowledge may lead to new diagnostic, therapeutic, or vaccine strategies, which may serve as important countermeasures to future SARS outbreaks. ..
  37. HSV 1 PROCESSING/PACKAGING GENES
    Sandra K Weller; Fiscal Year: 2010
    ..This grant will further our understanding of the mechanism by which this occurs and provide novel strategies for future antiviral therapies. - ..
  38. Regulation of Engraftment & Immunity by GD T Cells
    William Drobyski; Fiscal Year: 2005
    ....
  39. Role of proteoglycans in cocaine dependence
    Pietro Sanna; Fiscal Year: 2004
    ..The elucidation of the neurobiological bases for the transition from non-dependent drug use to addiction is of crucial importance for the development of novel and more effective therapeutic approaches. ..
  40. Endothelial Gene Delivery for Pulmonary Hypertension
    David Curiel; Fiscal Year: 2004
    ..abstract_text> ..
  41. Structural Specificity of Heparan Sulfate for Herpes Infections
    JIAN NONE LIU; Fiscal Year: 2010
    ..Our results could lead to a novel approach to treat herpes simplex virus infections and improve the basic understanding on the biosynthesis of HS with specific sulfonation patterns. ..
  42. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  43. Vascular Leukocytes Induce regulatory T cells (Treg) in Tumors
    George Coukos; Fiscal Year: 2010
    ....
  44. PRODRUGS FOR THERAPY OF VIRAL RETINITIS IN AIDS
    Karl Hostetler; Fiscal Year: 2002
    ....
  45. DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
    Bernard Roizman; Fiscal Year: 2002
    ..The experimental design includes identification of the products of alternative splicing and characterization of the role of the ligands in infection. ..
  46. Capsid-incorporation of HIV antigens as a novel adenovirus HIV vaccine approach
    David Curiel; Fiscal Year: 2008
    ..This project will design new and innovative methodologies to create HIV vaccines, in hopes of preventing the spread of HIV disease. ..
  47. Mechanisms of virus-induced apoptosis in neurons and CNS
    Kenneth L Tyler; Fiscal Year: 2010
    ..pathways involved, as well as an easily accessible in mouse model of CNS apoptosis that allows rapid testing of results obtained in cell culture for their significance on the pathogenesis of CNS viral disease in vivo ..
  48. GENE EXPRESSION PROFILING OF AIDS VACCINE STRATEGIES
    Michael Katze; Fiscal Year: 2007
    ..Ultimately, these studies may also suggest mechanisms to enhance current AIDS vaccine strategies. [unreadable] [unreadable] [unreadable]..
  49. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..abstract_text> ..
  50. Nonmyeloablative Allografting for Hematologic Neoplasia
    Michael Maris; Fiscal Year: 2005
    ....
  51. Activation of Apoptosis by a Simian Virus 5 Mutant
    GRIFFITH PARKS; Fiscal Year: 2005
    ..At the completion of this project, we will have established a firm baseline from which we can pursue detailed mechanistic questions concerning interactions of paramyxoviruses with host antiviral pathways. ..
  52. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  53. American Society for Neural Transplantation and Repair
    Caryl Sortwell; Fiscal Year: 2005
    ..This application requests $15,000 in total direct costs to support travel awards for the top 15 graduate students/postdocs from US institutions that apply (awards of $1000 per student/postdoc). ..
  54. Exploiting porcine cytomegalovirus stealth mechanisms
    MARK CREW; Fiscal Year: 2005
    ..The Phase I project will be deemed successful when we have identified specific genes from PCMV which impart stealth to pig cells in vitro when exposed to cells from the human immune system. ..
  55. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  56. Evaluation of Hypoxia in Grafted Dopamine Neurons
    Caryl Sortwell; Fiscal Year: 2005
    ..abstract_text> ..
  57. American Society for Neural Therapy and Repair
    Caryl Sortwell; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  58. Pirfenidone in Children with PNs in NF1
    Roger Packer; Fiscal Year: 2006
    ..Abstract Not Provided ..
  59. Herpes Simplex Virus Transmission Across Cell Junctions
    David Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. ENHANCING TUMOR VACCINES WITH CO-STIMULATORY MOLECULES
    Howard Kaufman; Fiscal Year: 2004
    ..This may have important implications for the future design of tumor vaccines in melanoma and other settings. ..
  61. CMV Immune Response & Long-Term Outcome of CMV Retinitis
    Mark Jacobson; Fiscal Year: 2005
    ....
  62. Liposomal Adjuvant for Vaccine Development
    Gary Fujii; Fiscal Year: 2008
    ..Moreover, liposomal formulations might also be discovered that could be developed into the next generation anthrax vaccine. [unreadable] [unreadable] [unreadable]..
  63. Adjunct rhIL-12 enhance THI response to viral vaccine?
    Mark Jacobson; Fiscal Year: 2004
    ..g. CMV, HSV and HIV). ..
  64. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Deveroux Ferguson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  65. Genital Herpes Vaccine Discovery
    Gary Fujii; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Production of a Lung Surfactant SP-B Mimic
    Gary Fujii; Fiscal Year: 2005
    ....
  67. MATURATION OF HERPESVIRAL NUCLEAR PROTEINS
    David Knipe; Fiscal Year: 2003
    ..These studies should provide information that is important for designing antiviral strategies for HSV and for engineering HSV-2 strains for genital herpes vaccines. ..
  68. Rapid Vaccine Development System
    Gary Fujii; Fiscal Year: 2002
    ..Evaluation of the anthrax antigen liposomes in preclinical animal models will be conducted in the Phase II studies. ..
  69. Non-Viral Pandemic Influenza Vaccine Development
    Gary Fujii; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  70. PHASE IB TRIAL OF CYTOMEGALOVIRUS GLYCOPROTEIN B VACCINE
    Paul Griffiths; Fiscal Year: 2008
    ..If a vaccine schedule can be identified which controls viral load, this will be recommended for a phase II placebo-controlled trial of clinical efficacy. ..
  71. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  72. Aberrant T Cell Function and Immunopathogenesis of CMV Immune Recovery Uveitis
    Mark Jacobson; Fiscal Year: 2008
    ..Thus, understanding the disease mechanism of CMV IRU could facilitate development of effective therapy for CMV IRU or diagnostic or treatment strategies to prevent CMV IRU. [unreadable] [unreadable] [unreadable]..
  73. Development of an Aspergillus Vaccine
    Gary Fujii; Fiscal Year: 2008
    ..Thus, a safe and effective vaccine against A. fumigatus would save health care dollars (and have significant dollar value) and, most importantly, save lives. [unreadable] [unreadable] [unreadable]..