hepatitis b virus

Summary

Summary: The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.

Top Publications

  1. ncbi Hepatitis B virus infection--natural history and clinical consequences
    Don Ganem
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
    N Engl J Med 350:1118-29. 2004
  2. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
  3. ncbi Hepatitis B virus infection
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Lancet 373:582-92. 2009
  4. ncbi Hepatitis B surface antigen quantification: why and how to use it in 2011 - a core group report
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 55:1121-31. 2011
  5. ncbi Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    Hongxing Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Nat Genet 42:755-8. 2010
  6. pmc Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
  7. ncbi Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes
    Helene Norder
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    Intervirology 47:289-309. 2004
  8. ncbi HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
    Chloe L Thio
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 360:1921-6. 2002
  9. ncbi Hepatitis B virus infection: epidemiology and vaccination
    Colin W Shepard
    Epidemiology Branch, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Rev 28:112-25. 2006
  10. pmc Infection of a human hepatoma cell line by hepatitis B virus
    Philippe Gripon
    Institut National de la Santé et de la Recherche Médicale INSERM U522, Hopital de Pontchaillou, 35033 Rennes, France
    Proc Natl Acad Sci U S A 99:15655-60. 2002

Detail Information

Publications339 found, 100 shown here

  1. ncbi Hepatitis B virus infection--natural history and clinical consequences
    Don Ganem
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, USA
    N Engl J Med 350:1118-29. 2004
  2. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
    More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma...
  3. ncbi Hepatitis B virus infection
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Lancet 373:582-92. 2009
    ..of hepatitis B virology, immunology, and the natural course of chronic infection, has identified hepatitis B virus replication as the key driver of immune-mediated liver injury and disease progression...
  4. ncbi Hepatitis B surface antigen quantification: why and how to use it in 2011 - a core group report
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 55:1121-31. 2011
    ..In clinical practice, serum HBsAg level should be used together with, but not as a substitute for, HBV DNA...
  5. ncbi Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    Hongxing Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Nat Genet 42:755-8. 2010
    To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in 355 chronic HBV carriers with HCC and 360 chronic HBV ..
  6. pmc Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
    ..The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future...
  7. ncbi Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes
    Helene Norder
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    Intervirology 47:289-309. 2004
    ..complete genomes and 631 hepatitis B surface antigen genes were used to assess the worldwide diversity of hepatitis B virus (HBV)...
  8. ncbi HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
    Chloe L Thio
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 360:1921-6. 2002
    Although coinfection with HIV-1 and hepatitis B virus (HBV) is common, few long-term studies on liver-disease mortality in coinfected people have been undertaken...
  9. ncbi Hepatitis B virus infection: epidemiology and vaccination
    Colin W Shepard
    Epidemiology Branch, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Rev 28:112-25. 2006
    Worldwide, two billion people have been infected with hepatitis B virus (HBV), 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or hepatocellular carcinoma...
  10. pmc Infection of a human hepatoma cell line by hepatitis B virus
    Philippe Gripon
    Institut National de la Santé et de la Recherche Médicale INSERM U522, Hopital de Pontchaillou, 35033 Rennes, France
    Proc Natl Acad Sci U S A 99:15655-60. 2002
    Among numerous established human hepatoma cell lines, none has been shown susceptible to hepatitis B virus (HBV) infection...
  11. ncbi The clinical implications of hepatitis B virus genotype: Recent advances
    Chih Lin Lin
    Department of Gastroenterology, Taipei City Hospital, Taiwan
    J Gastroenterol Hepatol 26:123-30. 2011
    Outcomes of chronic hepatitis B virus (HBV) infection are heterogeneous. Estimates of annual incidence of cirrhosis and hepatocellular carcinoma (HCC) are 2-10% and 1-3%, respectively...
  12. doi Hepatitis B virus infection
    Jules L Dienstag
    Gastrointestinal Unit Medical Services, Massachusetts General Hospital, and Department of Medicine and Office of the Dean for Medical Education, Harvard Medical School, Boston 02114, USA
    N Engl J Med 359:1486-500. 2008
  13. pmc Pathogenesis of hepatitis B virus infection
    F V Chisari
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pathol Biol (Paris) 58:258-66. 2010
    The adaptive immune response is thought to be responsible for viral clearance and disease pathogenesis during hepatitis B virus infection...
  14. pmc Serum microRNAs as biomarkers for hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection
    Peng Qi
    Department of Laboratory Medicine, Second Military Medical University, Eastern Hepatobiliary Hospital, Shanghai, China
    PLoS ONE 6:e28486. 2011
    ..The objective of this study was to investigate the potential of serum miRNAs as novel biomarkers for hepatocellular carcinoma (HCC)...
  15. ncbi Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    Dirk Grimm
    Stanford University, School of Medicine, Department of Pediatrics, Stanford, California 94305, USA
    Nature 441:537-41. 2006
    ..However, the risk of oversaturating endogenous small RNA pathways can be minimized by optimizing shRNA dose and sequence, as exemplified here by our report of persistent and therapeutic RNAi against human hepatitis B virus in vivo.
  16. pmc Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients
    Severine Margeridon-Thermet
    Department of Medicine, Stanford University, Stanford, CA, USA
    J Infect Dis 199:1275-85. 2009
    The dynamics of emerging nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI) resistance in hepatitis B virus (HBV) are not well understood because standard dideoxynucleotide direct polymerase chain reaction (PCR) sequencing ..
  17. pmc Hepatitis B virus replication
    Juergen Beck
    Department of Internal Medicine II Molecular Biology, University Hospital Freiburg, Hugstetter Street 55, D 79106 Freiburg, Germany
    World J Gastroenterol 13:48-64. 2007
    Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse transcription of an RNA intermediate, the pregenomic RNA (pgRNA)...
  18. ncbi Hepatitis B virus-cell interactions and pathogenesis
    David H Nguyen
    Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Physiol 216:289-94. 2008
    Like all viruses, hepatitis B virus (HBV) replication and pathogenesis depends on the critical interplay between viral and host factors...
  19. ncbi Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity
    Saifeng Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Hepatology 55:730-41. 2012
    b>Hepatitis B virus (HBV) causes chronic infection in about 350 million people worldwide...
  20. ncbi miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma
    Chun Mei Wang
    Department of Microbiology, Shandong University School of Medicine, Jinan 250012, PR China
    Biochem Biophys Res Commun 411:586-92. 2011
    ..Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their ..
  21. pmc Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis
    Asmaa Ibrahim Gomaa
    Department of Hepatology and Gastroenterology, Imperial College London, St Mary s Hospital Campus, Praed Street, London W2 1NY, United Kingdom
    World J Gastroenterol 14:4300-8. 2008
    ..This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance...
  22. ncbi Hepatitis B virus genotypes
    Anna Kramvis
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193 Johannesburg, South Africa
    Vaccine 23:2409-23. 2005
    Eight genotypes of hepatitis B virus (A-H) are currently recognized, and subgenotypes have recently been described in four of these genotypes (A, B, C and F)...
  23. ncbi Management of hepatitis B: summary of a clinical research workshop
    Jay H Hoofnagle
    Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 45:1056-75. 2007
    Chronic hepatitis B is caused by persistent infection with the hepatitis B virus (HBV), a unique DNA virus that replicates through an RNA intermediate produced from a stable covalently closed circular DNA molecule...
  24. pmc Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    Carolina Boni
    Laboratorio Immunopatologia Virale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Virol 81:4215-25. 2007
    ..We took advantage of the wide fluctuations in levels of viremia which are typical of chronic hepatitis B virus (HBV) infection to comprehensively analyze the impact of prolonged exposure to different virus quantities on ..
  25. pmc Molecular and phylogenetic analyses suggest an additional hepatitis B virus genotype "I"
    Hai Yu
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China
    PLoS ONE 5:e9297. 2010
    A novel hepatitis B virus (HBV) strain (W29) was isolated from serum samples in the northwest of China...
  26. ncbi Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    Bettina Werle-Lapostolle
    INSERM Unit 271, 151 Cours Albert Thomas, 69003 Lyon, France
    Gastroenterology 126:1750-8. 2004
    b>Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes...
  27. ncbi Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1
    Xiaoyong Zhang
    Institute of Virology, University Hospital of Essen, Essen, Germany
    Hepatology 53:1476-85. 2011
    ..Until now, the role of miRNAs in hepatitis B virus (HBV) replication has remained largely unknown...
  28. pmc Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment
    Jianhua Li
    Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China
    J Virol 85:6319-33. 2011
    ..The findings reported here demonstrate that hepatitis B virus (HBV) can enhance the autophagic process in hepatoma cells without promoting protein degradation by the ..
  29. ncbi New insight in the pathobiology of hepatitis B virus infection
    Maura Dandri
    Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    Gut 61:i6-17. 2012
    Chronic hepatitis B virus (HBV) infection remains a major health burden and the main risk factor for the development of hepatocellular carcinoma worldwide...
  30. pmc A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J
    Kanako Tatematsu
    Department of Clinical Molecular Informative Medicine, Nagoya, City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
    J Virol 83:10538-47. 2009
    b>Hepatitis B virus (HBV) of a novel genotype (J) was recovered from an 88-year-old Japanese patient with hepatocellular carcinoma who had a history of residing in Borneo during the World War II...
  31. ncbi Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
    Julie Lucifora
    Institute of Virology, Technische Universität München Helmholtz Zentrum München, Trogerstrasse, 30, 81675 Munich, Germany
    J Hepatol 55:996-1003. 2011
    The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.
  32. ncbi Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
    Patrick Marcellin
    Hopital Beaujon, Assistance Publique Hopitaux de Paris, University of Paris 7 and INSERM Unité 773, Centre de Recherches Claude Bernard sur les Hepatites Virales, Clichy, France
    N Engl J Med 359:2442-55. 2008
    Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and a potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase and hepatitis B virus (HBV) polymerase.
  33. ncbi Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210
    Guang Ling Zhang
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin 300070, China
    Antiviral Res 88:169-75. 2010
    ..In order to determine whether host-encoded miRNAs affect hepatitis B virus (HBV) replication, antisense oligonucleotides (ASOs) of 328 identified human miRNAs were transfected into ..
  34. pmc Use of massively parallel ultradeep pyrosequencing to characterize the genetic diversity of hepatitis B virus in drug-resistant and drug-naive patients and to detect minor variants in reverse transcriptase and hepatitis B S antigen
    Mariacarmela Solmone
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Virol 83:1718-26. 2009
    ..and reverse hybridization (line probe assay [LiPA])-based methods are the most common methods for detecting hepatitis B virus (HBV) drug resistance mutations, although only mutations present in viral quasispecies with a prevalence of &..
  35. ncbi Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
    Jinfeng Huang
    Department of Medical Genetics, Second Military Medical University, Shanghai, People s Republic of China
    Hepatology 52:60-70. 2010
    The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying mechanisms remain unknown...
  36. ncbi Lamivudine for patients with chronic hepatitis B and advanced liver disease
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    N Engl J Med 351:1521-31. 2004
    ..The effectiveness of antiviral therapy in preventing disease progression in patients with chronic hepatitis B and advanced fibrosis or cirrhosis is unknown...
  37. ncbi Control of cccDNA function in hepatitis B virus infection
    Massimo Levrero
    Department of Internal Medicine, Sapienza University of Rome, Policlinico Umberto I, 0061 Rome, Italy
    J Hepatol 51:581-92. 2009
    The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection...
  38. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    The risk of hepatocellular carcinoma (HCC) increases with increasing level of hepatitis B virus (HBV) in serum (viral load)...
  39. ncbi Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management
    Anna S Lok
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0362, USA
    Hepatology 46:254-65. 2007
    ..Thus, there is a need to standardize nomenclature relating to hepatitis B antiviral resistance, and to define genotypic, phenotypic, and clinical resistance to NA therapy...
  40. ncbi Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    Gastroenterology 131:1743-51. 2006
    ..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks...
  41. ncbi Homologous recombination between different genotypes of hepatitis B virus
    V Morozov
    Influenza Institute, Russian Academy of Medical Science, Prof Popov Str 15 17, 197376, St Petersburg, Russia
    Gene 260:55-65. 2000
    ..A possible mechanism and the implications of recombination for the natural history of HBV, clinically important properties, and phylogenetic reconstruction are discussed...
  42. pmc Recombination in the genesis and evolution of hepatitis B virus genotypes
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Virol 79:15467-76. 2005
    b>Hepatitis B virus (HBV) infection is widely distributed in both human and ape populations throughout the world and is a major cause of human morbidity and mortality...
  43. ncbi Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers
    Maurizia Rossana Brunetto
    Hepatology Unit, University Hospital of Pisa, University of Pisa, Pisa, Italy
    Gastroenterology 139:483-90. 2010
    The accurate identification of inactive (serum HBV-DNA persistently <or=2000 IU/mL) hepatitis B virus (HBV) carriers (IC) is difficult because of wide and frequent HBV-DNA fluctuations...
  44. ncbi Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    George K K Lau
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China
    N Engl J Med 352:2682-95. 2005
    ....
  45. ncbi Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy
    Daniel J Tenney
    Bristol Myers Squibb Company Research and Development, Wallingford, CT 06492, USA
    Hepatology 49:1503-14. 2009
    Patients with chronic hepatitis B virus (HBV) infection who develop antiviral resistance lose benefits of therapy and may be predisposed to further resistance...
  46. ncbi Occult hepatitis B
    Michael Torbenson
    Department of Pathology, Division of Gastrointestinal and Hepatic Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
    Lancet Infect Dis 2:479-86. 2002
    Worldwide, chronic hepatitis B virus (HBV) infection is the primary cause of cirrhosis and hepatocellular carcinoma and is one of the ten leading causes of death...
  47. ncbi Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: a perspective on Asia
    Tin Nguyen
    Department of Research and Molecular Development, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Vic, Australia
    J Hepatol 52:508-13. 2010
    ..We aimed to define the serum HBsAg titres during the different phases of CHB in a cohort of Asian patients infected with either genotype B or C HBV...
  48. pmc Possible new hepatitis B virus genotype, southeast Asia
    Christophe M Olinger
    National Public Health Laboratory Centre de Recherche Public Santé, Luxembourg, Luxembourg
    Emerg Infect Dis 14:1777-80. 2008
    We conducted a phylogenetic analysis of 19 hepatitis B virus strains from Laos that belonged to 2 subgenotypes of a new genotype I...
  49. ncbi Circulating microRNAs in hepatitis B virus-infected patients
    F Ji
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Molecular Virology and Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China
    J Viral Hepat 18:e242-51. 2011
    MicroRNAs (miRNAs) are stably present in human serum. The relationship between circulating miRNAs and hepatitis B virus (HBV) infected liver disease has not been previously reported...
  50. ncbi Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice
    Jun Wu
    Department of Gastroenterology and Hepatology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
    Hepatology 46:1769-78. 2007
    b>Hepatitis B virus (HBV) infection is one of the most frequent causes of chronic liver disease worldwide...
  51. ncbi Viral hepatitis B
    Ching Lung Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Lancet 362:2089-94. 2003
    More than 400 million people worldwide are chronically infected by the hepatitis B virus. The virus is responsible for more than 300000 cases of liver cancer every year and for similar numbers of gastrointestinal haemorrhage and ascites...
  52. ncbi Bayesian estimates of the evolutionary rate and age of hepatitis B virus
    Yang Zhou
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    J Mol Evol 65:197-205. 2007
    Accurately estimating the evolutionary rate and age of hepatitis B virus (HBV) has proven to be one of the most difficult problems in studies of viral evolution...
  53. pmc New complex recombinant genotype of hepatitis B virus identified in Vietnam
    Thien Tuan Huy Tran
    Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:5657-63. 2008
    A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98...
  54. ncbi Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
    N Engl J Med 348:808-16. 2003
    In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains.
  55. ncbi Hepatitis B virus genetic variability and evolution
    Alan Kay
    INSERM, U871, Physiopathologie moléculaire et nouveaux traitements des hépatites virales, 151 Cours A Thomas, Lyon F 69424, France
    Virus Res 127:164-76. 2007
    b>Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large amount of genetic diversity, despite the constraints imposed by the complex genetic organization of the viral genome...
  56. ncbi A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    N Engl J Med 354:1001-10. 2006
    Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV).
  57. pmc Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies
    Li Wang
    Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    PLoS ONE 6:e17608. 2011
    ..This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world...
  58. pmc The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
    Zhaoshi Jiang
    Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California 94080, USA
    Genome Res 22:593-601. 2012
    b>Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear...
  59. ncbi Impact of lamivudine on HIV and hepatitis B virus-related outcomes in HIV/hepatitis B virus individuals in a randomized clinical trial of antiretroviral therapy in southern Africa
    Gail V Matthews
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    AIDS 25:1727-35. 2011
    To examine HIV and hepatitis B virus (HBV)-related outcomes in HIV/HBV-coinfected participants in the PHIDISA II study by use of HBV-active vs. non-HBV-active antiretroviral therapy (ART).
  60. ncbi Hepatitis B viruses: reverse transcription a different way
    Michael Nassal
    University Hospital Freiburg, Internal Medicine 2 Molecular Biology, Hugstetter Str 55, D 79106 Freiburg, Germany
    Virus Res 134:235-49. 2008
    b>Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse transcription...
  61. pmc Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner
    Josef Kock
    Department of Medicine II, University Hospital of Freiburg, Freiburg, Germany
    PLoS Pathog 6:e1001082. 2010
    Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes ..
  62. pmc Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome
    Maria Homs
    Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto Carlos III Corsega 180, 08036, Barcelona, Spain
    Nucleic Acids Res 39:8457-71. 2011
    b>Hepatitis B virus (HBV) pregenomic RNA contains a hairpin structure (ε) located in the preCore region, essential for viral replication...
  63. ncbi Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus
    Anna Kramvis
    MRC CANSA University Molecular Hepatology Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Med Virol 80:27-46. 2008
    Using phylogenetic analysis and pairwise comparison of 670 complete hepatitis B virus (HBV) genomes, we demonstrated that nucleotide divergence greater than 7.5% can be used to separate strains into genotypes A-H...
  64. ncbi Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha
    Maya Mouler Rechtman
    The Institute of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    FEBS Lett 584:2485-90. 2010
    b>Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy...
  65. pmc Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Pathology Building Room 406, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Pathol 163:1101-7. 2003
    ..of SOCS-1, APC, and p15 was more frequently seen in hepatitis C virus-positive HCC than hepatitis C virus/hepatitis B virus-negative HCC...
  66. pmc A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    Ye Zhang
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Gastroenterology 141:1897-906. 2011
    ..IL-22 induces expression of proinflammatory genes but is also mitogenic and antiapoptotic in hepatocytes. Therefore, it could have multiple functions in the immune response to hepatitis B virus (HBV).
  67. ncbi Hepatitis B vaccines: protective efficacy and therapeutic potential
    M L Michel
    Laboratoire de pathogenèse des virus de l hépatite B, Institut Pasteur, Batiment Lwoff, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Pathol Biol (Paris) 58:288-95. 2010
    Worldwide, two billion people have at some time been infected by hepatitis B virus, 370 millions suffer from chronic infection and around one million die each year from HBV-related liver diseases of which liver cancer is the ultimate ..
  68. ncbi Identification of novel inter-genotypic recombinants of human hepatitis B viruses by large-scale phylogenetic analysis
    Weifeng Shi
    The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Virology 427:51-9. 2012
    Recombination plays an important role in the evolutionary history of Hepatitis B virus (HBV). We performed a phylogenetic analysis of 3403 full-length HBV genome sequences isolated from humans to define the genotype...
  69. ncbi The global impact of vaccination against hepatitis B: a historical overview
    Alessandro R Zanetti
    Department of Public Health Microbiology Virology, Faculty of Medicine, University of Milan, Via C Pascal 36, 20133 Milan, Italy
    Vaccine 26:6266-73. 2008
    b>Hepatitis B virus (HBV) infection is a world wide public health problem of major concern. HBV infection may lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC)...
  70. pmc Ethnogeographical structure of hepatitis B virus genotype distribution in Indonesia and discovery of a new subgenotype, B9
    Meta Dewi Thedja
    Eijkman Institute for Molecular Biology, Jakarta, Indonesia
    Arch Virol 156:855-68. 2011
    The distribution of hepatitis B virus (HBV) in the populations of island Southeast Asia is of medical and anthropological interest and is associated with an unusually high genetic diversity...
  71. ncbi Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a
    Patrick Marcellin
    Service d Hepatologie, U773 CRB3, Hopital Beaujon, University of Paris, Clichy, France
    Gastroenterology 136:2169-2179.e1-4. 2009
    ..The durability of <or=3-year posttreatment response was investigated in this study...
  72. ncbi Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase
    Peter Angus
    Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
    Gastroenterology 125:292-7. 2003
    Adefovir dipivoxil effectively inhibits both hepatitis B virus (HBV) replication and disease activity in patients with chronic hepatitis B...
  73. ncbi HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up
    Chia Ming Chu
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Hepatology 45:1187-92. 2007
    ..In multivariate analysis, the probability of HBsAg seroclearance correlated positively with age at entry (P<0.0001) and sustained remission of hepatitis (P<0.0001) and marginally significantly with male sex (P=0.053)...
  74. pmc Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs
    Thomas J Cradick
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Mol Ther 18:947-54. 2010
    b>Hepatitis B virus (HBV) chronically infects 350-400 million people worldwide and causes >1 million deaths yearly...
  75. pmc Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen
    Nicoletta Potenza
    Department of Life Sciences, Second University of Naples, Via Vivaldi 43, 81100 Caserta, Italy
    Nucleic Acids Res 39:5157-63. 2011
    ..In this study, the analysis of the hepatitis B virus (HBV) genome by the computer program MiRanda led to the identification of seven sites that are potential ..
  76. ncbi Telbivudine versus lamivudine in patients with chronic hepatitis B
    Ching Lung Lai
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 357:2576-88. 2007
    Reducing hepatitis B virus (HBV) replication to minimal levels is emerging as a key therapeutic goal for chronic hepatitis B.
  77. ncbi Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax
    Xiaohong Liang
    Institute of Immunology, School of Medicine, Shandong University, Jinan, People s Republic of China
    J Immunol 178:503-10. 2007
    b>Hepatitis B virus (HBV) infection afflicts >300 million people worldwide and is a leading cause of hepatocyte death, cirrhosis, and hepatocellular carcinoma...
  78. pmc Meta-analysis: adefovir dipivoxil in combination with lamivudine in patients with lamivudine-resistant hepatitis B virus
    En Qiang Chen
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    Virol J 6:163. 2009
    ..The aim of study was to evaluate the efficacy of rescue therapy with ADV plus LAM compared to ADV monotherapy in LAM-resistant CHB patients...
  79. pmc Viral hepatocarcinogenesis
    W L Tsai
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Oncogene 29:2309-24. 2010
    ..Despite recent advances in the diagnosis and treatment of HCC, its prognosis remains dismal. Infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major risk factors for HCC...
  80. ncbi Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain
    Bo Gao
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, People s Republic of China
    Hepatology 50:424-33. 2009
    ..Here we report that TRIM22 is involved in antiviral immunity against hepatitis B virus (HBV)...
  81. pmc The enigmatic X gene of hepatitis B virus
    Michael J Bouchard
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Virol 78:12725-34. 2004
  82. ncbi Interaction of hepatitis B virus, chemical carcinogen, and genetic susceptibility: multistage hepatocarcinogenesis with multifactorial etiology
    Chien Jen Chen
    Hepatology 36:1046-9. 2002
  83. ncbi Hepatitis B virus resistance to nucleos(t)ide analogues
    Fabien Zoulim
    INSERM, U871, Lyon, France
    Gastroenterology 137:1593-608.e1-2. 2009
    ..chronic hepatitis B (CHB) can be successfully treated using nucleos(t)ide analogs (NA), but drug-resistant hepatitis B virus (HBV) mutants frequently arise, leading to treatment failure and progression to liver disease...
  84. ncbi Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy
    Winnie Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hepatology 43:209-20. 2006
  85. ncbi Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B
    E Jenny Heathcote
    University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 140:132-43. 2011
    Tenofovir disoproxil fumarate (TDF), a nucleotide analogue and potent inhibitor of hepatitis B virus (HBV) polymerase, showed superior efficacy to adefovir dipivoxil in treatment of chronic hepatitis B through 48 weeks...
  86. ncbi Epidemiology, risk factors, and natural history of hepatocellular carcinoma
    Giuseppe Montalto
    Institute of Internal Medicine, Institute of Development Biology, CNR, University of Palermo, Palermo, Italy
    Ann N Y Acad Sci 963:13-20. 2002
    ..Thus, the ideal target population should be limited to Child-Pugh's class A cirrhotic patients without significant comorbidity...
  87. ncbi Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    Qing Hai Ye
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    Nat Med 9:416-23. 2003
    ..Thus, osteopontin acts as both a diagnostic marker and a potential therapeutic target for metastatic HCC...
  88. ncbi Frequency and load of hepatitis B virus DNA in first-time blood donors with antibodies to hepatitis B core antigen
    Holger Hennig
    Institute of Immunology and Transfusion Medicine, University of Lubeck, Germany
    Blood 100:2637-41. 2002
    The objective of this study was to determine the frequency and load of hepatitis B virus (HBV) DNA in anti-HBc-positive first-time blood donors; it was designed to contribute to determining whether anti-HBc screening of blood donations ..
  89. ncbi A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons
    Guo bing Zeng
    Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
    World J Gastroenterol 10:3132-6. 2004
    Traditional hepatitis B virus (HBV) genotyping methods using restriction fragment length polymorphism (RFLP) can reliably identify genotypes A to F...
  90. ncbi Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir
    Nancy Leung
    Alice Ho Miu Ling Nethersole Hospital, Taipo, Hong Kong SAR, China
    Hepatology 49:72-9. 2009
    ..At week 48, one (3%) ETV-treated versus 15 (47%) ADV-treated patients had HBV DNA of 10(5) copies/mL or more. Both antivirals were well tolerated...
  91. pmc Rapid and sensitive assays for determination of hepatitis B virus (HBV) genotypes and detection of HBV precore and core promoter variants
    Munira Hussain
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    J Clin Microbiol 41:3699-705. 2003
    b>Hepatitis B virus (HBV) genotypes may influence HBeAg seroconversion rates, mutational patterns in the precore (PC) and core promoter (CP) regions, severity of liver disease, and response to antiviral treatment...
  92. ncbi Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors
    Giovanna Fattovich
    Department of Surgical and Gastroenterological Sciences, University of Verona, Piazzale L A Scuro, 10, Verona 37134, Italy
    J Hepatol 48:335-52. 2008
    The natural history of chronic hepatitis B virus (HBV) infection and disease is complex and highly variable...
  93. ncbi Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B
    Robert G Gish
    Division of Hepatology and Complex GI, California Pacific Medical Center, San Francisco, California, USA
    Gastroenterology 133:1437-44. 2007
    ..We evaluated continued entecavir and lamivudine treatment through 96 weeks...
  94. ncbi Occult hepatitis B virus infection and its clinical implications
    Ke Qin Hu
    Transplantation Institute and Division of Gastroenterology, Loma Linda University Medical Center and Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92354, USA
    J Viral Hepat 9:243-57. 2002
    Occult hepatitis B virus (HBV) infection is characterized by presence of HBV infection with undetectable hepatitis B surface antigen (HBsAg). Serum HBV level is usually less than 104 copies/mL in these patients...
  95. ncbi Global control of hepatitis B virus infection
    Jia Horng Kao
    Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    Lancet Infect Dis 2:395-403. 2002
    Worldwide about 350 million people are chronic carriers of the hepatitis B virus (HBV). The infection can cause acute and chronic liver disease including cirrhosis and hepatocellular carcinoma (HCC)...
  96. ncbi Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
    Maurizia Rossana Brunetto
    UO Epatologia, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Hepatology 49:1141-50. 2009
    We investigated the relationship between hepatitis B virus surface antigen (HBsAg) serum level decline and posttreatment response in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B from a large multinational ..
  97. ncbi Hepatitis B virus genotypes, subgenotypes, precore, and basal core promoter mutations in the two largest provinces of Pakistan
    Choudhary Shoaib Ahmed
    Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    J Gastroenterol Hepatol 24:569-73. 2009
    b>Hepatitis B virus (HBV) genotyping has been done in most countries, but unfortunately, in Pakistan, HBV genotypic distribution is still unclear...
  98. ncbi Genotype X/C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam--genotypes B4 and C1 predominate
    Thi Bich Thuy Phung
    National Hospital of Paediatrics, Hanoi, Vietnam
    J Med Virol 82:1327-33. 2010
    There are eight known genotypes of hepatitis B virus, A-H, and several subgenotypes, with rather well-defined geographic distributions. HBV genotypes were evaluated in 153 serum samples from Hanoi, Vietnam...
  99. ncbi Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection
    Peng Qi
    Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China
    Hum Immunol 71:621-6. 2010
    ..whether this polymorphism is associated with susceptibility to and clinicopathologic characteristics of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), a total of 560 patients with chronic HBV infection and 391 ..
  100. ncbi Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
    Yu Wang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Hepatol 53:57-66. 2010
    The pleiotropic hepatitis B virus (HBV) x protein (HBx), associated with hepatocellular carcinoma (HCC), has been implicated in the deregulation of cellular gene expression at the transcriptional level...
  101. ncbi Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice
    Yanyan Zheng
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 45:16-21. 2007
    ..This effect of HBV does not involve chronic liver inflammation, is apparently due to enhanced hepatocellular apoptosis and compensatory regeneration following DEN treatment, and does not require the HBV X protein...

Research Grants70

  1. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..b>Hepatitis B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and ..
  2. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..serodiagnostic antigens for non-biodefense targets including: Bartonella henselae, Borrelia burgdorferi, Hepatitis B Virus, Chlamydia, Plasmodium falciparum, Human papillomavirus, and Herpes simplex virus...
  3. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..The numbers of annual deaths due to infections by Salmonella Typhi and S. Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for about ..
  4. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..wild type and chimeric VLPs will be evaluated in delivery of DNA vaccine encoding the surface antigen of hepatitis B virus, as potential gene carrier for treatment of chronic progressive hepatitis B...
  5. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..With a continuing focus on the roles of infection with hepatitis B virus and co-exposure to the fungal toxin aflatoxin on human risk for hepatocellular carcinoma, we will purse ..
  6. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is the most common cause of chronic viral liver disease worldwide...
  7. Mechanism(s) of Hepatocyte Transformation by the Hepatitis B Virus X Protein
    Ourania M Andrisani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Hepatitis B Virus (HBV) infection is a major factor in the pathogenesis of hepatocellular carcinoma (HCC)...
  8. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus (HBV) infection affects approximately 350 million people worldwide and is a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC)...
  9. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ..sex hormone testosterone may play a role in increasing risk of liver cancer due to another viral infection, Hepatitis B virus. Our group recently demonstrated that increased testosterone levels were associated with significantly ..
  10. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..compared with adjacent non-tumor tissues, and test whether the miRNA methylation levels are different for hepatitis B virus (HBV) and hepatitis C virus (HCV)-related HCC;(2) To examine whether a subgroup of miRNA genes showing ..
  11. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    There are an estimated 350 million people worldwide who are chronically infected with hepatitis B virus (HBV) and are at high risk for the development of hepatitis, cirrhosis (end stage liver disease) and hepatocellular carcinoma (HCC)...
  12. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    Chronic Hepatitis B virus (HBV) infection is linked to hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis by an unknown mechanism...
  13. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..Epidemiological studies have suggested that hepatitis B virus infection and dietary aflatoxin B1 (AFB1) are the two major etiological agents for human HCC...
  14. Liver cancer risk and prevention among persons living with HIV/AIDS
    LESLEY SUEJEAN PARK; Fiscal Year: 2013
    ..population, impaired immune function, and high prevalence of liver cancer risk factors hepatitis C virus, hepatitis B virus, an alcohol abuse and dependency contribute to the rising incidence of liver cancer among PLWHA...
  15. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..tests, from 28 weeks'gestation until two months postpartum to prevent perinatal transmission of hepatitis B virus (HBV)...
  16. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that results in a self-limited acute infection in a majority of otherwise healthy individuals but can also cause chronic infection, ..
  17. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The liver is also a target for persistent viral infections, such as chronic infections with the hepatitis B virus (HBV)...
  18. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that causes acute and chronic hepatitis and kills a million people each year from cirrhosis of the liver and hepatocellular ..
  19. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma (HCC)...
  20. Hepatic Non-viral Gene Therapy
    Leaf Huang; Fiscal Year: 2013
    ..Over 2 billion people have been infected with the hepatitis B virus (HBV) and 350 million live with chronic HBV infection worldwide, about 25% of whom die from liver fibrosis/..
  21. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis C and hepatitis B virus infections in humans are characterized by hepatocellular necrosis, inflammation, and development of hepatoma...
  22. Role of Hepatitis B virus X protein in HBV replication
    Michael J Bouchard; Fiscal Year: 2011
    Individuals with a chronic hepatitis B virus (HBV) infection of the liver have an increased risk for developing hepatocellular carcinoma (HCC)...
  23. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human ..
  24. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a partially double-stranded DNA virus that causes acute and hepatitis in humans...
  25. Hepatitis B virus X protein modulation of calcium signaling in HCC development
    JESSICA GARNER; Fiscal Year: 2013
    ..to exposure to various toxins or infectious agents, the majority of HCC cases are associated with chronic hepatitis B virus (HBV) infections...
  26. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus, hepatitis C virus, hepatitis A virus, respiratory syncytial virus, and human immunodeficiency virus and ..
  27. Role of Pellino1 in liver inflammation
    Liselotte E Jensen; Fiscal Year: 2010
    ..It is estimated that over 2 billion people worldwide are infected with hepatitis B virus (HBV) or hepatitis C virus (HCV)...
  28. The Environment as a Variable to Calibrate Mouse Models of Human Disease
    John M Essigmann; Fiscal Year: 2013
    ..an established risk factor for human hepatocellular carcinoma that strongly elevates risk in synergy with hepatitis B virus infection...
  29. Pathogenesis of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2011
    Many viral infections induce liver pathology, and the association of infection, by hepatitis B virus and hepatitis C virus, with the development of cirrhosis and hepatoma in humans, highlights the need to understand mechanisms regulating ..
  30. NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE
    BRIAN JAMES MCMAHON; Fiscal Year: 2012
    Infections from hepatitis A virus (HAV) and hepatitis B virus (HBV) are significant problems in Alaska Natives. Hepatitis A and B vaccines have been routine immunizations in Alaska Natives since 1984 and 1994, respectively...
  31. Discovery of novel anti-HBV compounds targeting host factors
    Pavel A Petukhov; Fiscal Year: 2013
    ..approach to discover lead candidates suitable for further lead optimization as therapeutics for chronic hepatitis B virus (HBV) infections...
  32. Mechanism of CCC DNA Synthesis in Hepatitis B Virus
    Christoph Seeger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Investigations on hepatitis B virus (HBV) and related animal viruses, particularly duck hepatitis B virus (DHBV), have provided a detailed model of the hepadnavirus replication cycle...
  33. HBx regulation of miRNA-mediated mRNA silencing in HCC development.
    RICHARD JASON LAMONTAGNE; Fiscal Year: 2013
    ..It is known however, that chronic infection with the hepatitis B virus (HBV) is one of the leading risk factors for developing HCC...
  34. 10-Theory and Experiment for Genome Packaging in HBV Nucleocapsids
    JIANZHONG contact WU; Fiscal Year: 2010
    ..Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Hepatitis B virus (HBV) infects more than 2 billion people alive today and is responsible for over 1 million deaths caused by ..
  35. Virologic and Serologic Outcomes of Persons with HIV and HBV co-infection on Mono
    JUDITH ANN ABERG; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Hepatitis B Virus (HBV) infection is a significant cause of morbidity and mortality among those with Human Immunodeficiency ..
  36. Hepatitis B Virus PreS2 Mutant as Risk Factor for Hepatocellular Carcinoma
    Eric J Huang; Fiscal Year: 2010
    ..b>Hepatitis B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and hepatocellular ..
  37. Intervention of HBV DNA synthesis and transcription
    Aleem Siddiqui; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus infections affect about 300 million people worldwide and constitute a significant risk factor for fibrosis and hepatocellular carcinoma (HCC)...
  38. Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
    Hee Soon Juon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) infection is globally most common and serious viral infection of the liver. It can cause premature death from liver diseases or liver cancer...
  39. Metabolic control of hepatitis B virus (HBV) biosynthesis: role of FXR and SHP
    VANESSA CURRAGH REESE; Fiscal Year: 2010
    This fellowship will support the study of the metabolic control of hepatitis B virus (HBV) biosynthesis...
  40. Occult Hepatitis B Infection in South African HIV Patients
    Jason T Blackard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Globally, 350 million people are chronically infected with hepatitis B virus (HBV) - the world's leading cause of cirrhosis and hepatocellular carcinoma (HCC)...
  41. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..been combined with alum (AS04) in two FDA-approved vaccines (Cervarix (Human Papilloma Virus), and Fendrix (Hepatitis B Virus))...
  42. Serum microRNA signature as prospective HCC biomarker in HBV patients
    Hushan Yang; Fiscal Year: 2012
    ..b>Hepatitis B virus (HBV) infection is the most prominent etiologic factor for HCC...
  43. Understanding The Structural Basis of APOBEC Functions
    Xiaojiang S Chen; Fiscal Year: 2012
    ..especially Apo3G, can restrict important viral pathogens, including Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV), and retro-element mobility...
  44. Effect of Chronic Alcohol on Liver APC and Ag-Specific T-Cells
    KATHERINE BREMPELIS; Fiscal Year: 2013
    ..site for the development of an immune response against pathogens such as Hepatitis C virus (HCV) and Hepatitis B virus (HBV), as well as the main site of alcohol metabolism...
  45. Molecular Modulation of Virus Capsid Assembly
    Adam Zlotnick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B Virus (HBV) is an enveloped DNA virus with an RNA intermediate. The core of the virus assembles as a protein shell around a viral mRNA and reverse transcriptase...
  46. 2013 International Meeting on the Molecular Biology of Hepatitis B Viruses
    Shuping Tong; Fiscal Year: 2013
    ..since 1985, is the only forum that gathers the international community of researchers focusing on the hepatitis B virus (HBV) and the closely associated hepatitis delta virus (HDV)...
  47. MODELING VIRAL AND T LYMPHOCYTE DYNAMICS
    Alan S Perelson; Fiscal Year: 2012
    ..Infection by hepatitis C virus (HCV) and hepatitis B virus (HBV) continue to cause liver failure and hepatocellular carcinoma in infected individuals...
  48. MODELING VIRAL AND T LYMPHOCYTE DYNAMICS
    Alan S Perelson; Fiscal Year: 2011
    ..Infection by hepatitis C virus (HCV) and hepatitis B virus (HBV) continue to cause liver failure and hepatocellular carcinoma in infected individuals...
  49. Designer Nucleases to Cure Chronic Hepatitis B
    Christoph Seeger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus causes chronic infections in approximately 350 million people worldwide. All are at significantly increased risk of developing hepatocellular carcinoma...
  50. 2010 Molecular Biology of Hepatitis B Viruses Meeting
    Adam Zlotnick; Fiscal Year: 2010
    ..by applicant): Approximately 25% of the earth's population, 2 billion people, have been infected by Hepatitis B Virus (HBV). Approximately 360 million people suffer from chronic infection...
  51. Preclinical Development of SB 44 as an Orally Bioavailable Anti-HBV Agent
    Radhakrishnan P Iyer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute and chronic liver infections caused by Hepatitis B virus (HBV) constitute a major worldwide public health problem...
  52. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2012
    Abstract The hepatitis B virus (HBV) remains a global cause of chronic liver diseases, including liver cirrhosis and cancer. Current antiviral therapy for chronic hepatitis B is only partially effective...
  53. Characterization of novel regulators of amino acid-sensitive mTORC1 signaling
    LAWRENCE SCHWEITZER; Fiscal Year: 2013
    ..Additionally, this protein has been shown to be a cellular target of a Hepatitis B virus oncogene, possibly implicating a role for mTORC1 in both viral infection and Hepatitis B virus-associated ..
  54. HBV Response to Tenofovir or Lamivudine-Based ART in HIV-HBV Co-Infected Chinese
    Chloe L Thio; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The majority of persons with chronic hepatitis B virus (HBV) infection live in resource-limited settings (RLS) such as China where 10-20% of the 780,000 HIV-infected patients are co-infected with HBV...
  55. Role of cytokine induction in APOBEC3-mediated virus restriction
    CHIOMA OKEOMA; Fiscal Year: 2011
    ..of cells in culture by Vif-deficient human immunodeficiency virus 1 (HIV-1), primate foamy virus (PFV), hepatitis B virus (HBV), murine leukemia virus (MuLV), and mouse mammary tumor virus (MMTV)...
  56. Computational Studies of Early Stage Cell Entry Events by Non-enveloped Viruses
    ERIC ROBERT MAY; Fiscal Year: 2013
    ..of several virus systems so far, including Sesbania mosaic virus, cowpea chlorotic mottle virus, HK97, hepatitis B virus, and Norwalk virus. This work has been impactful in interpreting AFM nanoindentation studies on viruses...
  57. Hepatitis B Virus X protein and Alcohol Regulation of Cell Cycle Progression
    TRICIA LEIGH GEARHART; Fiscal Year: 2010
    ..with known risk factors;common risk factors include chronic infections of the liver with the human hepatitis B virus (HBV) and chronic alcohol consumption...
  58. Novel therapeutic approaches to treating chronic hepatitis B virus infection
    Lishan Su; Fiscal Year: 2013
    ..There is currently no cure for the 350 million patients who are already chronically infected with hepatitis B virus (HBV)...
  59. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a major cause of chronic viral hepatitis that increases dramatically the risk of liver cancer and other end-stage liver diseases such as cirrhosis...
  60. Molecular Prognostic Indicators in Liver Cirrhosis and Cancer
    Yujin Hoshida; Fiscal Year: 2013
    ..HCC develops from advanced fibrosis due to hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, or non-alcoholic fatty liver disease (NAFLD)...
  61. Persistence of hepatitis delta virus infection in absence of HBV replication
    Severin O Gudima; Fiscal Year: 2013
    ..HDV is a natural subviral agent of human hepatitis B virus (HBV). HDV uses HBV envelope proteins to form virions and infect hepatocytes...
  62. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes-Schiffer; Fiscal Year: 2013
    ..The biomedical relevance of this ribozyme is that HDV increases the severity of liver diseases caused by hepatitis B virus, and replication of HDV depends on self-cleavage of the HDV ribozyme...
  63. Plant-Derived hepatitis B Vaccine from Biomanufacturing System to Clinical Trial
    Robert Britt; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: More than 2 billion of the global population have been infected with hepatitis B virus estimated to cause 500,000 to 700,000 deaths each year worldwide...
  64. DRW HIV-Ab/HBsAg Duplex Rapid Test submission for FDA-PMA approval
    Helen Lee; Fiscal Year: 2009
    ..of human immunodeficiency virus (HIV) infection and hepatitis B surface antigen (HBsAg) for diagnosis of hepatitis B virus (HBV) infection...
  65. CD07-005, Translating Research into the Jade Ribbon Campaign
    Samuel So; Fiscal Year: 2009
    ..Major gaps exist in the timely identification and immunization of infants born to women infected with hepatitis B virus (HBV)...
  66. An HBV polymerase RNA binding assay suitable for inhibitor screening
    Feng Cao; Fiscal Year: 2009
    b>Hepatitis B virus (HBV) is a hepatotropic DNA virus that replicates by reverse transcription. It chronically infects over 350 million people worldwide and causes 600,000 deaths annually...
  67. VIRAL HEPATITIS IN CHILDREN OF INJECTION DRUG USERS
    Kathleen Schwarz; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Hepatitis B virus (HBV) and hepatitis C virus (HCV) are endemic among adult injection drug users (IDUs)...
  68. HEPATITIS B VIRUS - CHRONIC HEPATITIS - LIVER CANCER
    DAVID SHAFRITZ; Fiscal Year: 1991
    Our overall goal is to study regulation of hepatitis B virus (HBV) gene expression and events in virus replication in human, animal model and cell culture systems and to investigate mechanisms whereby persistent infection with hepatitis ..
  69. Structural Studies of HBsAg: Support for Quentin Florence
    QUENTIN FLORENCE; Fiscal Year: 2009
    DESCRIPTION (provided by investigator): Hepatitis B virus (HBV) is a blood-born-associated virus that has infected over 2 billion people worldwide. It is also one of the major causes of liver cancer...
  70. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) remains a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV is a member of the hepadnavirus group, double-stranded DNA viruses...