human adenoviruses

Summary

Summary: Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with arabic numbers) have been grouped into species designated Human adenovirus A-F.

Top Publications

  1. ncbi Evidence of frequent recombination among human adenoviruses
    Alexander N Lukashev
    Bute Medical School, University of St Andrews, Scotland, UK
    J Gen Virol 89:380-8. 2008
  2. ncbi Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
    Gerry Shaw
    University of Florida College of Medicine, Department of Neuroscience, McKnight Brain Institute, Gainesville, Florida, USA
    FASEB J 16:869-71. 2002
  3. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
  4. pmc Real-time PCR quantification of human adenoviruses in urban rivers indicates genome prevalence but low infectivity
    Samuel Choi
    Environmental Health, Science, and Policy, University of California, Irvine, CA 92697 7070, USA
    Appl Environ Microbiol 71:7426-33. 2005
  5. pmc Molecular detection and quantitative analysis of the entire spectrum of human adenoviruses by a two-reaction real-time PCR assay
    K Ebner
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, A 1090 Vienna, Austria
    J Clin Microbiol 43:3049-53. 2005
  6. pmc Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children
    Yae Jean Kim
    Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
    J Clin Microbiol 41:4594-9. 2003
  7. ncbi Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene
    X Lu
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Arch Virol 151:1587-602. 2006
  8. pmc Quantitative real-time PCR assays for detection of human adenoviruses and identification of serotypes 40 and 41
    Narayanan Jothikumar
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F 36, Atlanta, Georgia 30341, USA
    Appl Environ Microbiol 71:3131-6. 2005
  9. pmc Structural and phylogenetic analysis of adenovirus hexons by use of high-resolution x-ray crystallographic, molecular modeling, and sequence-based methods
    John J Rux
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:9553-66. 2003
  10. pmc A capsid-encoded PPxY-motif facilitates adenovirus entry
    Harald Wodrich
    Institut Génétique Moléculaire de Montpellier, Montpellier, France
    PLoS Pathog 6:e1000808. 2010

Detail Information

Publications236 found, 100 shown here

  1. ncbi Evidence of frequent recombination among human adenoviruses
    Alexander N Lukashev
    Bute Medical School, University of St Andrews, Scotland, UK
    J Gen Virol 89:380-8. 2008
    ..Comparison of the right end (nt 18838-33452) of this isolate with that of the ATCC Ad6 strain showed clear evidence of multiple recombination events...
  2. ncbi Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
    Gerry Shaw
    University of Florida College of Medicine, Department of Neuroscience, McKnight Brain Institute, Gainesville, Florida, USA
    FASEB J 16:869-71. 2002
    ....
  3. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
    ..Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors...
  4. pmc Real-time PCR quantification of human adenoviruses in urban rivers indicates genome prevalence but low infectivity
    Samuel Choi
    Environmental Health, Science, and Policy, University of California, Irvine, CA 92697 7070, USA
    Appl Environ Microbiol 71:7426-33. 2005
    Real-time PCR was applied to quantify the abundance of human adenoviruses in two southern California urban rivers, the San Gabriel and Los Angeles...
  5. pmc Molecular detection and quantitative analysis of the entire spectrum of human adenoviruses by a two-reaction real-time PCR assay
    K Ebner
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, A 1090 Vienna, Austria
    J Clin Microbiol 43:3049-53. 2005
    ..information of the hexon gene, we were able to develop a two-reaction real-time PCR assay covering all human adenoviruses with equally high specificity and sensitivity...
  6. pmc Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children
    Yae Jean Kim
    Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
    J Clin Microbiol 41:4594-9. 2003
    ..In conclusion, the data confirm that Ad3 genome types are more diverse than those of Ad7 and suggest that shifts of genome types may occur during successive outbreaks of Ad3 and Ad7...
  7. ncbi Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene
    X Lu
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Arch Virol 151:1587-602. 2006
    b>Human adenoviruses (Ads) are responsible for a substantial disease burden. Type-specific identification of Ads can help guide therapeutic and disease prevention strategies and aid epidemiological investigations...
  8. pmc Quantitative real-time PCR assays for detection of human adenoviruses and identification of serotypes 40 and 41
    Narayanan Jothikumar
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F 36, Atlanta, Georgia 30341, USA
    Appl Environ Microbiol 71:3131-6. 2005
    A quantitative real-time TaqMan PCR assay for detection of human adenoviruses (HAdV) was developed using broadly reactive consensus primers and a TaqMan probe targeting a conserved region of the hexon gene...
  9. pmc Structural and phylogenetic analysis of adenovirus hexons by use of high-resolution x-ray crystallographic, molecular modeling, and sequence-based methods
    John J Rux
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:9553-66. 2003
    ..The combination of crystallography, molecular modeling, and phylogenetic analysis defines a conserved molecular core that can serve as the armature for the directed design of novel hexons...
  10. pmc A capsid-encoded PPxY-motif facilitates adenovirus entry
    Harald Wodrich
    Institut Génétique Moléculaire de Montpellier, Montpellier, France
    PLoS Pathog 6:e1000808. 2010
    ..Our data provide the first evidence that virus-encoded PPxY motifs are required during virus entry, which may be of significance for several other pathogens...
  11. ncbi Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis
    J Y Hong
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Clin Infect Dis 32:1423-9. 2001
    ..The data confirm that adenovirus types 3 and 7 can cause epidemics of severe LRTI in young children. Epidemics of LRTIs caused by adenovirus types 3 and 7 in Korea have not been described in reports published elsewhere...
  12. pmc Typing of human adenoviruses in specimens from immunosuppressed patients by PCR-fragment length analysis and real-time quantitative PCR
    Karin Ebner
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, A 1090 Vienna, Austria
    J Clin Microbiol 44:2808-15. 2006
    ..Moreover, in view of the increasing importance of tailored therapy approaches, serotype identification may in the future have implications for the selection of the most appropriate antiviral treatment...
  13. ncbi Development of stable liquid formulations for adenovirus-based vaccines
    Robert K Evans
    Department of Vaccine Pharmaceutical Research, Merck Research Laboratories, WP78 302, Sumneytown Pike, West Point, PA 19486, USA
    J Pharm Sci 93:2458-75. 2004
    ..The identification of 4 degrees C stable liquid formulations should significantly enhance the utility of Ad5 as a vector for vaccines and gene therapy...
  14. ncbi The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study
    Jost Hillenkamp
    The Eye Hospital, Heinrich Heine University, Dusseldorf, Germany
    Ophthalmology 109:845-50. 2002
    ..To evaluate the efficacy of cidofovir 1% eyedrops with and without cyclosporin A 1% eyedrops as a treatment of acute adenoviral keratoconjunctivitis (AKC)...
  15. ncbi Human adenoviruses in water: occurrence and health implications: a critical review
    Sunny C Jiang
    Department of Civil and Environmental Engineering, University of California, Irvine, California 92697, USA
    Environ Sci Technol 40:7132-40. 2006
    ..The occurrence of these viruses in natural and treated waters is summarized from worldwide reports...
  16. ncbi Rapid and quantitative detection of human adenovirus DNA by real-time PCR
    Albert Heim
    Institute for Virology, German National Reference Laboratory for Adenoviruses, Hannover Medical School, Germany
    J Med Virol 70:228-39. 2003
    ..1 x 10(10) copies/ml), which were associated with symptoms of disseminated disease. In conclusion, real-time PCR is a sensitive and quantitative procedure for the detection of adenovirus infections...
  17. ncbi Structure of the dodecahedral penton particle from human adenovirus type 3
    P Fuschiotti
    Laboratoire de Microscopie Electronique Structurale, Institut de Biologie Structurale, UMR 5075 CNRS CEA UJF, Grenoble, France
    J Mol Biol 356:510-20. 2006
    ..The structural work provides a sound basis for manipulating the properties of this particle and thereby enhancing its value for such therapeutic use...
  18. ncbi Adenovirus serotype evolution is driven by illegitimate recombination in the hypervariable regions of the hexon protein
    L K Crawford-Miksza
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Berkeley 94704, USA
    Virology 224:357-67. 1996
    ..This mutability in the surface regions of the major viral coat protein confers a distinct survival advantage to this family of viruses...
  19. ncbi Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy
    Kathryn Hall
    Institute of Molecular and Cellular Biology, University of Leeds, UK
    Biochem J 431:321-36. 2010
    ..Such species-specific differences, as well as adaptations or modifications of Ads required for applications in gene therapy, form the major focus of the present review...
  20. pmc Adenovirus dodecahedron allows large multimeric protein transduction in human cells
    P Fender
    Institut de Biologie Structurale, 38027 Grenoble, France
    J Virol 77:4960-4. 2003
    ..We show here that this dodecameric particle, devoid of genetic information, efficiently penetrates human cells and can deliver large multimeric proteins such as immunoglobulins...
  21. pmc Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy
    Ijad Madisch
    Institut fur Virologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Virol 79:15265-76. 2005
    b>Human adenoviruses (HAdV) are responsible for a wide spectrum of diseases. The neutralization epsilon determinant (loops 1 and 2) and the hemagglutination gamma determinant are relevant for the taxonomy of HAdV...
  22. ncbi Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers
    Arguinaldo R Pinto
    The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 171:6774-9. 2003
    ..They are equivalent to sequential vaccinations with an E1-deleted Ad vector followed by booster immunization with a poxvirus vector and they surpass regimens based on DNA vaccine prime followed by a recombinant adenoviral vector boost...
  23. ncbi Human adenovirus-36 antibody status is associated with obesity in children
    Richard L Atkinson
    Obetech Obesity Research Center, Richmond, VA 23219, USA
    Int J Pediatr Obes 5:157-60. 2010
    ..Ad-36 prevalence is 30% in obese adults, but prevalence has not been reported in childhood obesity...
  24. ncbi Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases
    Richard Galinier
    Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble, France
    Biochemistry 41:14299-305. 2002
    ..This is the first demonstration of the interaction of nonenveloped viruses with ubiquitin-protein ligases of host cells...
  25. pmc Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection
    Emily K Nguyen
    10550 N Torrey Pines Rd, IMM19, La Jolla, CA 92037, USA
    J Virol 84:4041-9. 2010
    ..Using this assay, we now provide direct evidence that human alpha-defensins block adenovirus infection by preventing uncoating during cell entry...
  26. pmc Evidence of molecular evolution driven by recombination events influencing tropism in a novel human adenovirus that causes epidemic keratoconjunctivitis
    Michael P Walsh
    Department of Bioinformatics and Computational Biology, George Mason University, Manassas, VA, USA
    PLoS ONE 4:e5635. 2009
    ..This documents the first genomic, bioinformatic, and biological descriptions of the molecular evolution events engendering an emerging pathogenic adenovirus...
  27. ncbi Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients
    Bianca Heemskerk
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 191:520-30. 2005
    ..Only a few data on the correlation between immune recovery and the course of HAdV infection are available, and data on HAdV-specific responses are lacking...
  28. pmc Molecular epidemiology of adenovirus type 7 in the United States, 1966-2000
    Dean D Erdman
    Divivion of Viral ans Ricksettial Diseases, Centers for Disease Control and Prevention, Mailstio G 09, 1600 Clifton Road, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:269-77. 2002
    ..The appearance of Ad7d2 and Ad7h in North America represents recent introduction of these viruses from previously geographically restricted areas and may herald a shift in predominant genome type circulating in the United States...
  29. ncbi Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection
    A C Lankester
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 38:1521-5. 2004
    ....
  30. pmc Development and characterization of bovine x human hybrid cell lines that efficiently support the replication of both wild-type bovine and human adenoviruses and those with E1 deleted
    Alberto L van Olphen
    Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA
    J Virol 76:5882-92. 2002
    ..of HAV5 and efficiently supported the replication of both wild-type and replication-incompetent bovine or human adenoviruses. Transient gene expression experiments with a plasmid encoding the bacterial beta-galactosidase gene ..
  31. ncbi Improved growth of enteric adenovirus type 40 in a modified cell line that can no longer respond to interferon stimulation
    Victoria Sherwood
    Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonnington Campus, Loughborough LE12 5RD, UK
    J Gen Virol 88:71-6. 2007
    ..These results suggest that the defect in HAdV-40 in counteracting the IFN response can be overcome at least partially through the use of 293-SV5/V cell lines...
  32. ncbi Adenovirus-directed ocular innate immunity: the role of conjunctival defensin-like chemokines (IP-10, I-TAC) and phagocytic human defensin-alpha
    Stephen A K Harvey
    Charles T Campbell Laboratorym University of Pittsburgh, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:3657-65. 2005
    ..In the present study, cultured human conjunctival epithelial cells were used to identify host genes responsive to infection by a clinical isolate of Ad5, and the antiviral activity of some of their peptide products was investigated...
  33. ncbi Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay
    Sallene Wong
    Provincial Laboratory for Public Health Microbiology, Alberta, Canada
    J Med Virol 80:856-65. 2008
    b>Human adenoviruses (hAdVs) are associated with acute respiratory tract infections in pediatric populations and have been identified as a cause of outbreaks in institutional settings...
  34. pmc Molecular diagnosis of human adenoviruses d and e by a phylogeny-based classification method using a partial hexon sequence
    Yasushi Shimada
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Shimura 3 30 1, Itabashi ku, Tokyo 174 8555, Japan
    J Clin Microbiol 42:1577-84. 2004
    b>Human adenoviruses (HAdVs) are the major causes of a variety of acute illnesses...
  35. pmc Functional diversity of E1A gene autoregulation among human adenoviruses
    J D Cogan
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Virol 66:3833-45. 1992
    ..type 3 (Ad3) E1A gene is presented and compared with that of the E1A genes of similar and distantly related human adenoviruses. The cDNA forms of the Ad3 E1A gene, corresponding to two major early mRNA species, are cloned, sequenced, ..
  36. ncbi Relationship between F-specific RNA phage genogroups, faecal pollution indicators and human adenoviruses in river water
    Leslie Ogorzaly
    Laboratory of Physical Chemistry and Microbiology for the Environment LCPME, UMR 7564 CNRS Nancy Universite, Faculte de Pharmacie, 5 rue Albert Lebrun, 54000 Nancy, France
    Water Res 43:1257-64. 2009
    ..the first time, positive correlations between the concentrations of genogroup II, bacterial indicators and human adenoviruses were observed, which may indicate a human faecal pollution...
  37. ncbi Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study
    J Hillenkamp
    The Eye Hospital, Heinrich Heine University, Dusseldorf, Germany
    Arch Ophthalmol 119:1487-91. 2001
    ..To evaluate the efficacy of 0.2% cidofovir eyedrops and 1% cyclosporine eyedrops administered 4 times daily (qid) to treat acute adenoviral keratoconjunctivitis...
  38. ncbi Comparison of methods for concentrating human adenoviruses, polyomavirus JC and noroviruses in source waters and drinking water using quantitative PCR
    Nestor Albinana-Gimenez
    Department of Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    J Virol Methods 158:104-9. 2009
    ..This study compared concentration and nucleic acid extraction methods and defines a protocol for quantifying human adenoviruses (HAdV), JC polyomavirus (JCPyV) and noroviruses (NoV) in source and drinking water...
  39. ncbi Association between human adenovirus-36 and lipid disorders in Korean schoolchildren
    H N Na
    Department of Biotechnology, The Catholic University of Korea, Wonmi gu, Bucheon, Korea
    Int J Obes (Lond) 34:89-93. 2010
    ..Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren...
  40. ncbi Growth characteristics of human adenoviruses on porcine cell lines
    Nadine Griesche
    Robert Koch Institut, Zentrum für Biologische Sicherheit 1, Nordufer 20, 13353 Berlin, Germany
    Virology 373:400-10. 2008
    b>Human adenoviruses (hAdV) have been recognized as a highly prevalent virus family causing severe disease in immunocompromised patients...
  41. ncbi Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypic cultures
    N Sanjib Banerjee
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Mol Cancer Ther 3:437-49. 2004
    ..These studies also demonstrate that organotypic cultures derived from mixtures of tumor and normal cells represent a promising new model for analysis of CRAd specificity and toxicity...
  42. pmc Quantitative detection of human adenoviruses in wastewater and combined sewer overflows influencing a Michigan river
    Theng Theng Fong
    Department of Crop and Soil Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Appl Environ Microbiol 76:715-23. 2010
    ..b>Human adenoviruses were monitored because of their high prevalence and persistence in aquatic environments...
  43. ncbi High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea
    Mpho Magwalivha
    Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    J Med Virol 82:77-84. 2010
    b>Human adenoviruses (HAdVs) cause a wide range of clinical syndromes and are classified in seven species, A-G, comprising 52 serotypes. HAdV-A31, -F40, and -F41 have been associated with diarrhea in infants and young children...
  44. pmc Simplified microneutralization test for serotyping adenovirus isolates
    M D Malasig
    Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, California 92186, USA
    J Clin Microbiol 39:2984-6. 2001
    ..The simplified test has faster turnaround time and was 96% concordant with a confirmatory test using serial dilutions of type-specific sera. This method will find utility in high-volume serotyping work...
  45. pmc Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization
    Kathryn M Frietze
    Infectious Disease Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    J Virol 84:11310-22. 2010
    Subspecies B1 human adenoviruses (HAdV-B1s) are important causative agents of acute respiratory disease, but the molecular bases of their distinct pathobiology are still poorly understood...
  46. pmc Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the 1995 nationwide outbreak in Japan
    Mamoru Noda
    Department of Bacteriology, Hiroshima University School of Medicine, Hiroshima, Japan
    J Clin Microbiol 40:140-5. 2002
    ..The results also suggest that the low mass immunity in Japan was critical for the outbreak and that the mutation in the E3 region in Ad7d2 may have influenced transmission...
  47. ncbi Human adenoviruses in respiratory infections: sequencing of the hexon hypervariable region reveals high sequence variability
    Barbara Biere
    Robert Koch Institut, Nationales Referenzzentrum für Influenza, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 47:366-71. 2010
    In respiratory infections, human adenoviruses (hAdV) of species B1 and C are frequently detected, but severe or even fatal disease outbreaks are predominantly caused by only few serotypes...
  48. ncbi Outbreak of adenovirus genome type 7d2 infection in a pediatric chronic-care facility and tertiary-care hospital
    S I Gerber
    Chicago Department of Public Health, Westside Center for Disease Control, Chicago, IL, 60612, USA
    Clin Infect Dis 32:694-700. 2001
    ..Thus, Ad7d2 caused significant morbidity and mortality in persons in the pediatric chronic-care facility and tertiary-care hospital. This is the first published description of Ad7d2 strains in the United States...
  49. ncbi Chimpanzee adenoviruses are related to four subgenera of human adenoviruses
    R Wigand
    , , Homburg, FRG
    Intervirology 30:1-9. 1989
    ..The strains belonged to six serotypes, and all of them were clearly related to, but not identical to human adenoviruses of subgenus A, B, C, or E respectively. DNA restriction analysis corroborated these relationships.
  50. pmc Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen
    Michael P Walsh
    Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd, MSN 5B3, Manassas, Virginia 20110, USA
    J Clin Microbiol 48:991-3. 2010
    Novel human adenoviruses (HAdVs) arise from genome recombination. Analysis of HAdV type 55 from an outbreak in China shows a hexon recombination between HAdV-B11 and HAdV-B14, resulting in a genome that is 97.4% HAdV-B14...
  51. pmc Human adenoviruses and coliphages in urban runoff-impacted coastal waters of Southern California
    S Jiang
    Department of Environmental Analysis and Design, University of California, Irvine, California 92697, USA
    Appl Environ Microbiol 67:179-84. 2001
    ..b>Human adenoviruses were detected in 4 of the 12 samples tested after nucleic acid extraction of VFF concentrates...
  52. pmc Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein
    Natalya Belousova
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:8621-31. 2002
    ....
  53. ncbi Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
    M C Bewley
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Science 286:1579-83. 1999
    ..The structure identifies key determinants of binding specificity, which may suggest ways to modify the tropism of adenovirus-based gene therapy vectors...
  54. ncbi Increased adiposity in animals due to a human virus
    N V Dhurandhar
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI, USA
    Int J Obes Relat Metab Disord 24:989-96. 2000
    ..Four animal models of virus-induced obesity including adiposity induced by an avian adenovirus have been described previously. This is the first report of adiposity induced in animals by a human virus...
  55. ncbi Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001--2002
    Hsiu Lin Chen
    Department of Pediatrics, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung, Taiwan
    J Trop Pediatr 50:279-84. 2004
    ..This adenoviruses molecular epidemiological study provides information that helps physicians in clinical differential diagnosis and treatment of respiratory adenoviral infection in children in southern Taiwan...
  56. ncbi Human obesity relationship with Ad36 adenovirus and insulin resistance
    G M Trovato
    Department of Internal Medicine, Clinica di Medicina Interna e Terapia Medica, Facolta di Medicina e Chirurgia, Universita di Catania, Catania, Italy
    Int J Obes (Lond) 33:1402-9. 2009
    ..Moreover, the relationship, if any, among these factors and an earlier Ad36 infection, and the hypothesis of a mechanism involving IR are investigated...
  57. pmc Comprehensive detection and serotyping of human adenoviruses by PCR and sequencing
    Helen Sarantis
    Division of Microbiology, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    J Clin Microbiol 42:3963-9. 2004
    b>Human adenoviruses are common pathogens associated with many diseases, including respiratory, gastrointestinal, and ocular infections...
  58. ncbi Severe pneumonia due to adenovirus serotype 14: a new respiratory threat?
    Janice K Louie
    Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA 94804, USA
    Clin Infect Dis 46:421-5. 2008
    ..Fifty-two adenovirus serotypes have been recognized and classified within 7 subgroups or species (A-G), with limited data available on associated clinical syndromes and disease severity in more than one-half of the known serotypes...
  59. ncbi Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
    P W Roelvink
    Research and Development, GenVec Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20879, USA
    Science 286:1568-71. 1999
    ..The feasibility of simultaneous CAR ablation and redirection of an adenovirus to a new receptor is demonstrated...
  60. pmc Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate
    Christopher M Robinson
    The Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
    Virus Res 139:122-6. 2009
    ..Elucidation of the HAdV-19C genome will facilitate future studies into the pathogenesis of EKC, and may shed light on the genetic determinants of corneal tropism...
  61. pmc Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
    Danilo R Casimiro
    Department of Viral Vaccine Research, Merck and Company, West Point, Pennsylvania 19486, USA
    J Virol 77:6305-13. 2003
    ....
  62. ncbi The adenovirus capsid: major progress in minor proteins
    Jort Vellinga
    Virus Biology Laboratory, Department of Molecular Cell Biology, Leiden University Medical Centre, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    J Gen Virol 86:1581-8. 2005
    b>Human adenoviruses have been the subject of intensive investigation since their discovery in the early 1950s: they have served as model pathogens, as probes for studying cellular processes and, more recently, as efficient gene-delivery ..
  63. pmc Rapid typing of human adenoviruses by a general PCR combined with restriction endonuclease analysis
    A Allard
    Department of Virology, Umea University, Umea, Sweden
    J Clin Microbiol 39:498-505. 2001
    ..Used in combination, the PCR-RE digestion method and the nested PCR provide a reliable and sensitive system that can easily be applied to all kinds of clinical samples when rapid identification of adenoviruses is needed...
  64. ncbi Porcine adenoviral vectors evade preexisting humoral immunity to adenoviruses and efficiently infect both human and murine cells in culture
    Dinesh S Bangari
    Laboratory of Gene Therapy and Purdue University Cancer Center, 1290 Lynn Hall, Purdue University, West Lafayette, IN 47907, USA
    Virus Res 105:127-36. 2004
    Preexisting immunity against human adenoviruses (HAd) limits the efficiency of transduction of HAd vectors in humans...
  65. pmc Serological and genetic characterisation of a unique strain of adenovirus involved in an outbreak of epidemic keratoconjunctivitis
    A K Adhikary
    Infectious Diseases Surveillance Centre, National Institute of Infectious Diseases, Tokyo 162 86, Japan
    J Clin Pathol 57:411-6. 2004
    ..To characterise a novel strain of adenovirus (Ad) type Ad8 (genome type Ad8I) involved in an epidemic keratoconjunctivitis (EKC) outbreak in Hiroshima city using serological testing and sequence analysis of the fibre and hexon gene...
  66. pmc Quantitative detection and rapid identification of human adenoviruses
    Rika Miura-Ochiai
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Shimura 3 30 1, Itabashi ku, Tokyo 174 8555, Japan
    J Clin Microbiol 45:958-67. 2007
    We have established a method of quantitative detection and rapid identification of human adenoviruses (hAdVs)...
  67. pmc PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections
    David Metzgar
    Naval Health Research Center, P O Box 85122, San Diego, CA 92186 5122, USA
    J Clin Microbiol 43:5743-52. 2005
    ..In particular, coinfections may influence adenoviral evolution, as interserotypic recombination has been identified as a source of emerging strains...
  68. ncbi Porcine adenovirus serotype 3 internalization is independent of CAR and alphavbeta3 or alphavbeta5 integrin
    Dinesh S Bangari
    Laboratory of Gene Therapy, Department of Veterinary Pathobiology, and the Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Virology 332:157-66. 2005
    ..CAR- and alphavbeta3 or alphavbeta5 integrin-independent entry of PAd3 vectors may have implications in targeting cell types that are not efficiently transduced by other adenoviral vectors...
  69. pmc The Mre11 complex is required for ATM activation and the G2/M checkpoint
    Christian T Carson
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 22:6610-20. 2003
    ..These results demonstrate that the Mre11 complex can function as a damage sensor upstream of ATM/ATR signaling in mammalian cells...
  70. ncbi The complete nucleotide sequence, genome organization, and origin of human adenovirus type 11
    Daniel Stone
    Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Virology 309:152-65. 2003
    ..for a subgenera B human adenovirus and demonstrates a genome organization highly similar to those of other human adenoviruses. All of the genes from the early, intermediate, and late regions are present in the expected locations of ..
  71. pmc Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer
    R J Pickles
    CF Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 27599 7248, USA
    J Virol 74:6050-7. 2000
    ..These results indicate that adenovirus can infect via receptors located at the apical cell membrane but that the glycocalyx impedes interaction of AdV with apical receptors...
  72. pmc Role of alpha(v) integrins in adenovirus cell entry and gene delivery
    G R Nemerow
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Microbiol Mol Biol Rev 63:725-34. 1999
    ..Finally, unanswered questions arising from the current state of knowledge of Ad-receptor interactions are presented in the context of improving Ad vectors for future human gene therapy applications...
  73. pmc A quasi-atomic model of human adenovirus type 5 capsid
    Céline M S Fabry
    Laboratoire de Virologie Moleculaire et Structurale, FRE 2854 CNRS Université Joseph Fourier, Grenoble Cedex, France
    EMBO J 24:1645-54. 2005
    ..The capsid organisation is compared with the known X-ray structure of bacteriophage PRD1...
  74. ncbi Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance
    Maha Othman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada
    Blood 109:2832-9. 2007
    ..We conclude that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration...
  75. ncbi Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity
    S Kurachi
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, Osaka, Japan
    Gene Ther 14:1160-5. 2007
    ..These Ad vectors should be useful for gene functional analysis and gene therapy...
  76. pmc Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo
    O Kalyuzhniy
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Proc Natl Acad Sci U S A 105:5483-8. 2008
    ..This study describes the mechanism of FX binding to Ad5 and demonstrates the critical role of hexon for virus infection of hepatocytes in vivo...
  77. ncbi Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle
    Pascal Fender
    CNRS, CEA, UJF Institut de Biologie Structurale, 41 rue Jules Horowitz 38027 Grenoble, France
    Virology 371:155-64. 2008
    ..This provides new clues for the use of this adenovirus nanoparticle as a delivery vector and sheds light on the integrin and HSPGs relationship in both resting and dividing cells...
  78. ncbi Abrupt emergence of diverse species B adenoviruses at US military recruit training centers
    David Metzgar
    Respiratory Disease Laboratory, Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, CA 92186, USA
    J Infect Dis 196:1465-73. 2007
    ..Between 1999 and 2002, serotype 4 accounted for >95% of Ads isolated from recruits and for >50% of ARD cases in training facilities (15,000 cases/year)...
  79. ncbi Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways
    M Windheim
    Aventis, DG Metabolic Diseases, 65926 Frankfurt, Germany
    Curr Top Microbiol Immunol 273:29-85. 2004
    ..Thus, an unexpected link emerges between viral manipulation of intracellular transport pathways and immune evasion...
  80. ncbi Quantitative analysis of adenovirus-specific CD4+ T-cell responses from healthy adults
    M Olive
    Department of Medicine, Center for Human Virology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Viral Immunol 14:403-13. 2001
    ..This assay may be useful for the evaluation of adenovirus-specific CD4+ T-cell responses in patients treated with adenovirus gene therapy vectors and the identification of major T-cell epitopes...
  81. pmc Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus
    M Suomalainen
    , Institute of Zoology, Winterthurerstrasse 190, , Switzerland
    EMBO J 20:1310-9. 2001
    ..Our results demonstrate that complementary activities of PKA, p38 and MK2 tip the transport balance of adenovirus towards the nucleus and thus enhance infection...
  82. ncbi Adenovirus type 11 binding alters the conformation of its receptor CD46
    B David Persson
    Interfaculty Institute for Biochemistry, University of Tubingen, D 72076 Tubingen, Germany
    Nat Struct Mol Biol 14:164-6. 2007
    ..This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules...
  83. pmc Heterogeneity of the fibre sequence in subgenus C adenoviruses
    A K Adhikary
    Infectious Disease Surveillance Centre, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Clin Pathol 57:612-7. 2004
    ..To determine the nucleotide sequences of adenovirus (Ad) types 1 and 6 fibre genes; to clarify the molecular basis of the distinct haemagglutination properties of subgenus C Ads and their phylogenetic relations...
  84. ncbi Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes
    M Rathod
    Department of Nutrition and Food Science, Detroit, Michigan, USA
    Int J Obes (Lond) 31:78-86. 2007
    ..The objective of this study was to determine the adipogenic roles of viral mRNA and DNA, which may explain the differential effects of Ad-36 and Ad-2 on preadipocyte differentiation...
  85. pmc Association of adenovirus with the microtubule organizing center
    Christopher J Bailey
    Department of Genetic Medicine, Weill Graduate School of Medical Sciences, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Virol 77:13275-87. 2003
    ..In summary, the data demonstrate that the Ad capsid establishes a stable interaction with the MTOC when a nucleus is not present, suggesting that dissociation of Ad from microtubules likely requires nuclear factors...
  86. ncbi cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells
    A C Vertegaal
    Laboratory for Molecular Carcinogenesis, MGC Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 487:151-5. 2000
    ..This cellular gene was found to be the gene encoding follistatin-related protein, a TGF-beta inducible gene. Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells...
  87. pmc Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10
    Lee Anne Tibbles
    Department of Medicine Libin Gene Therapy Unit, University of Calgary Calgary, Alberta T2N 4N1, Canada
    J Virol 76:1559-68. 2002
    ....
  88. ncbi Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN
    William C Adams
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Gen Virol 90:1600-10. 2009
    ..A better understanding of the tropism and receptor mechanisms of Ad5 may help explain Ad5 pathogenesis and guide the engineering of improved rAd vectors...
  89. pmc Quantification and stability of human adenoviruses and polyomavirus JCPyV in wastewater matrices
    Silvia Bofill-Mas
    Department of Microbiology, Faculty of Biology, University of Barcelona, Av Diagonal 645, Barcelona 08028, Spain, and Department of Clinical Virology, Umea University Hospital, Sweden
    Appl Environ Microbiol 72:7894-6. 2006
    b>Human adenoviruses (HAdV) and human polyomavirus JCPyV have been previously proposed as indicators of fecal viral contamination in the environment...
  90. ncbi Immune evasion by adenoviruses
    J A Mahr
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Immunol Rev 168:121-30. 1999
    ..This review focuses on what is currently understood about how these immunomodulatory mechanisms work and how they might play a role in maintaining the virus in a persistent state...
  91. pmc Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus alpha(v) integrins
    N Arnberg
    Department of Virology, University of Umea, S 90185 Umea, Sweden
    J Virol 74:7691-3. 2000
    ..Here, we demonstrate that adenovirus type 8 (Ad8), Ad19a, and Ad37 use sialic acid as a functional cellular receptor, whereas the Ad9 and Ad19 prototypes do not...
  92. pmc Identification of specific cellular genes up-regulated late in adenovirus type 12 infection
    Andreas Dorn
    Institute for Clinical and Molecular Virology, Erlangen University, Schlossgarten 4, D 91054 Erlangen, Germany
    J Virol 79:2404-12. 2005
    ..Increased genetic activity of cellular genes late in adenovirus infection has not been reported previously and demonstrates that Ad12 has a sustained control of host cell gene expression well into the late phase of infection...
  93. ncbi Adenovirus E1A under the control of heterologous promoters: wide variation in E1A expression levels has little effect on virus replication
    M M Hitt
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Virology 179:667-78. 1990
    ..These results suggest that very low levels of E1A proteins are sufficient for virus production in cultured cells and that wild-type Ad 5 produces an amount of E1A in excess of that required...
  94. ncbi Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus
    C R Carlin
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Cell 57:135-44. 1989
    ..EGF-R is down-regulated in an analogous manner during early infection of a variety of cell types by group C human adenoviruses. This effect is not a function of viral entry, nor is it due to a nonspecific increase in turnover of ..
  95. pmc A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties
    P J Ulfendahl
    Department of Medical Genetics, Uppsala University, Sweden
    EMBO J 6:2037-44. 1987
    ....
  96. ncbi Human and simian adenoviruses: phylogenetic inferences from analysis of VA RNA genes
    A H Kidd
    Department of Medical Microbiology, University of Lund, Sweden
    Virology 207:32-45. 1995
    ..b>Human adenoviruses of subgenera A, B:2, and F have only one VA RNA gene, whereas human adenoviruses of subgenera B:1, C, D, and ..
  97. pmc Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo
    C Hofmann
    HepaVec AG für Gentherapie, 13122 Berlin Buch, Germany
    J Virol 73:6930-6. 1999
    Recombinant human adenoviruses (hAd) have become widely used as tools to achieve efficient gene transfer...
  98. ncbi Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals
    Leah D Whigham
    Obetech Obesity Research Center, 800 E Leigh St, Suite 50, Richmond, VA 23219, USA
    Am J Physiol Regul Integr Comp Physiol 290:R190-4. 2006
    ..This study evaluated whether three other human adenoviruses increase adiposity in chickens and in 3T3-L1 cells in vitro...
  99. pmc Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation
    Maitreyi S Rajala
    Molecular Pathogenesis of Eye Infection Research Center, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Virol 79:12332-41. 2005
    ..The results presented in this paper provide the first direct evidence that PI3K-mediated Akt activation in adenovirus-infected corneal cells may contribute to viral pathogenesis by the prolongation of cell viability...
  100. ncbi Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey
    Barbara Chmielewicz
    Robert Koch Institut, Projektgruppe 11, HIV Variabilität und Molekulare Epidemiologie, Nordufer 20, Berlin, Germany
    J Med Virol 77:232-7. 2005
    ..The adenovirus detected was characterized further by genotyping and was identified as a species B2 virus with the highest similarity to adenovirus type 11a...
  101. ncbi Adenovirus infections in hematopoietic stem cell transplant recipients
    D S Howard
    Blood and Marrow Transplant Program, Division of Hematology and Oncology, Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
    Clin Infect Dis 29:1494-501. 1999
    ..A multiple logistic regression analysis showed that isolating adenovirus from more than 1 site correlated with greater risk for invasive infections (P=.002). Invasive infections were associated with poorer chance of survival...

Research Grants63

  1. Modulation of Rab7-Dependent Degradative Pathways by Novel Adenovirus Protein
    Cathleen R Carlin; Fiscal Year: 2012
    ..molecular and cellular mechanisms employed by an integral membrane protein encoded by the early region 3 of human adenoviruses called RID[unreadable], which was originally identified because of its ability to divert constitutively ..
  2. Oral Immunization Against Malaria with Recombinant Adenoviruses
    GARY W KETNER; Fiscal Year: 2010
    ..Work proposed here will investigate an approach to malaria immunization modeled on oral vaccines against human adenoviruses that have been used safely and effectively in millions of people for over three decades...
  3. Apoptosis Regulation by Adenovirus and Cellular Genes
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2013
    ..In cells infected with human adenoviruses (Adv), the proteins coded by the early region E1A play a central role in inducing apoptosis and the process ..
  4. Molecular mechanism of immune evasion by the E3-19K protein of Adenovirus
    Marlene Bouvier; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human Adenoviruses (Ads) are large DNA viruses that cause diseases ranging from gastrointestinal and upper respiratory tract infections to eye infections...
  5. Mechanisms of the Adenovirus E4-ORF1 Oncoprotein
    Ronald T Javier; Fiscal Year: 2013
    ..Among human adenoviruses, adenovirus type 9 is unique in causing exclusively estrogen-dependent mammary tumors in experimental ..
  6. Hamster Model for Oncolytic Adenovirus Vectors
    WILLIAM SM WOLD; Fiscal Year: 2010
    ..mouse model is commonly used to evaluate oncolytic adenovirus vectors because the dogma holds that human adenoviruses do not replicate in animals...
  7. Adenovirus myocarditis: defining host factors contributing to pathogenesis
    JASON BRICE WEINBERG; Fiscal Year: 2013
    ..Associations between myocarditis and infection with human adenoviruses (Ad) have been well established, but strict species specificity limits studies of human adenovirus ..
  8. Molecular interactions between soluable host factors and a gene delivery vector
    Vijay S Reddy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human adenoviruses (HAdV) are nonenveloped dsDNA viruses that infect a variety of cell types. Species C HAdV5 is the most commonly used vector for gene therapy and vaccine applications in the clinic...
  9. ROLE OF CELL INTEGRINS IN ADENOVIRAL CONJUNCTIVITIS
    Glen R Nemerow; Fiscal Year: 2012
    Project Summary/Abstract Human adenoviruses are major causes of acute infections of the respiratory, gastrointestinal tract, and the eye...
  10. BIOCHEMISTRY OF VIRAL REPLICATION
    Maurice Green; Fiscal Year: 2013
    ..The laboratory of Dr. Maurice Green has made many seminal contributions which have helped to develop the human adenoviruses (Ad) as prototype systems to study virus replication, cell transformation, and the molecular biology of the ..
  11. Oral, replicating Ad4-HIV vaccine development &evaluation in NHP challenge model
    JONATHAN FOWLER SMITH; Fiscal Year: 2013
    ..Since human adenoviruses such as Ad4 do not replicate in non-human animals, including NHPs, we will also construct analogous ..
  12. X-ray diffraction analysis of human adenoviruses
    Vijay S Reddy; Fiscal Year: 2013
    ....
  13. Syrian Hamster as a Permissive Model for Testing Anti-Adenovirus Drugs
    William Wold; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Human adenoviruses (Ads) are a significant problem in immunosuppressed humans, especially in children undergoing allogeneic stem cell transplants...
  14. ANIMAL MODELS OF VIRUS INDUCED OBESITY
    Richard Atkinson; Fiscal Year: 2000
    ..The objectives of the protocol are to determine if AD-36 is specific among human adenoviruses in causing obesity, to determine if AD-36 produces obesity in other animal models, specifically in mammals, ..
  15. Encapsidation of Adenovirus DNA
    Michael J Imperiale; Fiscal Year: 2010
    ..The human adenoviruses are associated with a variety of diseases including upper respiratory infections, gastrointestinal illness, ..
  16. Modulation of Adenoviral Infections by CD44
    CRISTHIAN J ILDEFONSO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Worldwide, human adenoviruses (Ad) cause 8% of viral infections responsible for a spectrum of diseases such as respiratory, gastro-intestinal, and urogenital tract infections, and keratoconjunctivitis...
  17. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..population and fail to carry neutralizing B cell epitopes that cross-react with the common serotypes of human adenoviruses. Lack of preexisting virus-neutralizing antibodies in the human population suggests that these novel ..
  18. Canine model for evaluating CRAD efficacy
    Gene Siegal; Fiscal Year: 2005
    ..A major problem in the field of CRAD research is our inability to study host-vector interactions. Human adenoviruses do not productively replicate in mouse or other commonly used animal tissues...
  19. ADENOVIRUS GENOME EXPRESSION: PHYSICAL MAPPING STUDIES
    Clark Tibbetts; Fiscal Year: 1991
    ..The B subgroup of human adenoviruses, moderately oncogenic, is comprised of two closely related but epidemiologically and pathogenically distinct ..
  20. NONHUMAN ADENOVIRUS VECTORS FOR GENE THERAPY
    SURESH MITTAL; Fiscal Year: 2001
    ..b>Human adenoviruses have attracted considerable interest lately for their potential use as delivery vehicles for gene therapy ..
  21. GENETIC ANALYSES OF ADENOVIRUSES
    James Williams; Fiscal Year: 1992
    ..of this research program is to define the roles of viral genes in controlling the outcome of infection with human adenoviruses in both permissive and non- permissive cells...
  22. Animal Model for Adenovirus Oncolytic Vectors
    William Wold; Fiscal Year: 2004
    ..mouse model is commonly used to evaluate oncolytic adenovirus vectors because the dogma holds that human adenoviruses do not replicate in animals...
  23. TRANSCRIPTIONAL REGULATION OF ADENOVIRUS LATE GENES
    SARAH FLINT; Fiscal Year: 2007
    b>Human adenoviruses are under intense scrutiny as vehicles for gene therapy and as anticancer agents in humans...
  24. MOLECULAR MECHANISMS OF TNF-ADENOVIRUS INTERACTIONS
    Linda Gooding; Fiscal Year: 1991
    ..have determined that it is an abundant protein which is conserved in at least three of the seven groups of human adenoviruses. We hypothesize that the 14.7K protein evolved to protect virus infected cells against lysis by TNF...
  25. mRNA Export Regulation in adenovirus-Infected Cells
    SARAH FLINT; Fiscal Year: 2003
    b>Human adenoviruses are under intense scrutiny as vehicles for gene therapy and as anticancer agents in humans...
  26. SPECIALIZED CANCER CENTER (CORE) GRANT
    Maurice Green; Fiscal Year: 1980
    ..Studies will be completed analyzing human cancer tissues not yet screened for nucleic acid sequences of groups A to E human adenoviruses and BK virus.
  27. Strategies to Enhance Adenoviral Mediated Tumor Killing
    John Hay; Fiscal Year: 2004
    ..Safety aspects are difficult to evaluate in a mouse model as human adenoviruses do not replicate in mouse cells...
  28. ADENOVIRUS T AND SURFACE ANTIGENS AND TUMORIGENICITY
    Karel Raska; Fiscal Year: 1990
    b>Human adenoviruses induce tumors in rodents in vivo and can also efficiently transform cells in vitro...
  29. VIRAL CARCINOGENESIS AND LATENCY
    William Strohl; Fiscal Year: 1980
    ..b>Human adenoviruses are viewed as convenient probes in tumor biology generally rather than as candidates for a major etiological ..
  30. REPLICATION OF RNA TUMOR VIRUSES
    Maurice Green; Fiscal Year: 1980
    ..the next year are the identification of proteins in cells transformed by mammalian sarcoma viruses and by human adenoviruses that are (1) viral coded, and (2) cell coded and virus induced or modified, which may contribute to the ..
  31. Genetic Variability and Virulence of Human Adenovirus 7
    Adriana Kajon; Fiscal Year: 2005
    ..abstract_text> ..
  32. ONCOLYTIC ADENOVIRUSES FOR CERVICAL CANCER GENE THERAPY
    Andre Lieber; Fiscal Year: 2009
    ....
  33. Evaluation of vectors based on group B adenoviruses
    Andre Lieber; Fiscal Year: 2009
    ..These studies will be performed in transgenic mice that express B-group Ad receptors. Based on this, we will select representative vectors and parameters and repeat biodistribution and safety studies in baboons. ..
  34. X-ray diffraction analysis of human adenovirus
    Vijay Reddy; Fiscal Year: 2006
    ..et al. Science 309: 1090-1092, 2005). [unreadable] [unreadable] [unreadable]..
  35. TRIMODAL GENE THERAPY FOR PROSTATE CANCER
    SVEND FREYTAG; Fiscal Year: 2003
    ....
  36. Adenovirus & Human Obesity - Longitudinal & Twin Studies
    Richard Atkinson; Fiscal Year: 2001
    ..The potential impact on worldwide public health may be enormous. ..
  37. Gene Therapy for HPV-Associated Malignancies
    Andre Lieber; Fiscal Year: 2006
    ..Finally, even if the rate of tumor transduction with the viral vector is limited, an anti-tumor immune response will lead to lysis of tumor cells that were originally not transduced. ..
  38. ADENOVIRUS-RECEPTOR INTERACTION--STRUCTURE, FUNCTION
    Paul Freimuth; Fiscal Year: 2004
    ..Our results also may have application to the development of vaccines and anti- viral drugs, and they will impact efforts to retarget the tropism of adenovirus-based vectors for gene therapy. ..
  39. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..4. NS3/NS5 interaction is regulated by phosphorylation and subcellular location of NS5. The PI proposes to test the hypothesis that the nuclear NS5 regulates the expression of cellular gene(s) in response to viral infection. ..
  40. Molecular Basis of Myocilin Function in the Human Eye
    W Daniel Stamer; Fiscal Year: 2010
    ..abstract_text> ..
  41. FAS LIGAND GENE TRANSFER IN ARTHRITIS
    Youhai Chen; Fiscal Year: 2001
    ..Information generated from these studies may help elucidate the mechanisms by which FasL gene transfer diminishes autoimmune arthritis and may lead to the development of a novel strategy for treatment of autoimmune arthritis. ..
  42. REGULATION OF PSEUDOMONAS INDUCED LUNG INFLAMMATION
    Christopher Wilson; Fiscal Year: 2003
    ..Hypothesis: CFTR KO mice will have excessive lung inflammation. This will reflect a process intrinsic to the lung and will parallel and be dependent, at least in part, on NF-kappaB activation in the airway epithelium. ..
  43. AUTOIMMUNE ENCEPHALOMYELITIS AND NF-KB
    Youhai Chen; Fiscal Year: 2003
    ..Novel strategies targeting NF-kappaB may then be developed to treat or prevent autoimmune diseases. ..
  44. Cancer dual-targeting of an infectivity-enchanced CRAd
    J Mathis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. VIRAL PROTEINS THAT INHIBIT FAS AND TNFR1 SIGNALING
    Linda Gooding; Fiscal Year: 2002
    ..and begun to characterize a series of unique proteins, encoded within the E3 transcription unit of human adenoviruses. Two of these proteins, called 10.4K and 14...
  46. E1A-INDUCED CELLULAR SENSITIZATION TO APOPTOSIS
    James Cook; Fiscal Year: 2002
    ..abstract_text> ..
  47. CADHERIN DYNAMICS AND GLAUCOMA
    W Daniel Stamer; Fiscal Year: 2010
    ..Results obtained from these investigations will provide a basic understanding of the role of cadherin proteins in aqueous outflow resistance and uncover novel therapeutic targets for glaucoma therapy. ..
  48. Autoimmune encephalomyelitis and Bcl-2- interacting mediator
    Youhai H Chen; Fiscal Year: 2010
    ....
  49. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  50. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2007
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. [unreadable] [unreadable]..
  51. Recombinant Adenovirus Vaccines Against B. anthracis
    Michael Imperiale; Fiscal Year: 2006
    ..b>Human adenoviruses are DNA viruses that generally cause mild, self-limiting infections in healthy individuals...
  52. Lanthanides as Novel Anti-Arthritic Agents
    Christopher Evans; Fiscal Year: 2004
    ..A successful outcome to these studies will have identified the basis for a potential new, very inexpensive anti-rheumatic agent whose mode of action differs from that of existing drugs. ..
  53. HOST DEFENSE TO NEONATAL INRACELLULAR PATHOGENS
    Christopher Wilson; Fiscal Year: 2008
    ..These studies will provide insights into mechanisms for host defense against Lm and for the greater susceptibility of the neonate to this and related intracellular bacterial pathogens. ..
  54. First International Inflammatory Breast Cancer Conference
    Massimo Cristofanilli; Fiscal Year: 2008
    ..For project details please see "Conference Plan". [unreadable] [unreadable] [unreadable]..
  55. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  56. SELENIUM-INDUCED GLAUCOMA
    W Stamer; Fiscal Year: 2006
    ..abstract_text> ..
  57. Novel Nanostructured Calcium Phosphate for Gene Delivery to Bone
    Christopher Evans; Fiscal Year: 2005
    ..2. To evaluate the ability of nCaP-vector constructs to enhance osteogenic responses in vivo. ..
  58. Interactions of AAV with Cellular Factors
    Matthew Weitzman; Fiscal Year: 2006
    ..Understanding the role of cellular components in regulating AAV replication and integration will enhance our ability both to produce and utilize this promising vector system. ..
  59. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  60. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2009
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  61. CADHERIN REGULATION OF AQUEOUS HUMOR OUTFLOW
    W Stamer; Fiscal Year: 2004
    ..abstract_text> ..
  62. AAV and the DNA Damage Machinery
    Matthew D Weitzman; Fiscal Year: 2010
    ..Therefore, in addition to providing insights into the fundamental process of recognition of damaged DNA, these studies will also have implications for genetic approaches to combat disease. ..