hypericum

Summary

Summary: Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.

Top Publications

  1. ncbi Determining hyperforin and hypericin content in eight brands of St. John's wort
    Gerlie C de los Reyes
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Am J Health Syst Pharm 59:545-7. 2002
  2. ncbi Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells
    C M Schempp
    Department of Dermatology, Photodermatology Unit, University Medical Center, Haupstr 7, D 79104 Freiburg, Germany
    Br J Dermatol 142:979-84. 2000
  3. ncbi [Biologically active substances isolated from Hypericum attenuatum Choisy]
    O Iu Makovets'ka
    M M Grishko National Botanical Garden, NAS of Ukraine, Kiev
    Ukr Biokhim Zh 72:110-3. 2000
  4. ncbi Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials
    S Kasper
    Department of Psychiatry und Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, 1090, Austria
    Eur Arch Psychiatry Clin Neurosci 258:59-63. 2008
  5. ncbi St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
    J Barnes
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London
    J Pharm Pharmacol 53:583-600. 2001
  6. ncbi Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro
    Yanping Zou
    State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, 200237, China
    J Agric Food Chem 52:5032-9. 2004
  7. ncbi Antimicrobial activity of some Hypericum species
    R Dall'agnol
    Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, RS, Brazil
    Phytomedicine 10:511-6. 2003
  8. pmc Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Malar J 10:167. 2011
  9. ncbi Contrasting plant physiological adaptation to climate in the native and introduced range of Hypericum perforatum
    John L Maron
    Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA
    Evolution 61:1912-24. 2007
  10. ncbi Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system
    O Grundmann
    College of Pharmacy, Department of Pharmaceutics, University of Florida, PO Box 100494, Gainesville, FL 32610, USA
    Neuropharmacology 58:767-73. 2010

Research Grants

  1. Botanical Treatments in Social Anxiety Disorder
    Kathryn Connor; Fiscal Year: 2005
  2. R21 Project: St. John's Wort vs. Placebo in OCD
    Kenneth Kobak; Fiscal Year: 2003
  3. St. John's wort for Drug Abuse Treatment During Pregnancy
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2012
  4. Botanicals and Metabolic Syndrome
    William T Cefalu; Fiscal Year: 2013
  5. Mood Disorders Clincal Intervention Training Program
    Madhukar H Trivedi; Fiscal Year: 2013
  6. Hypericum extracts as potential anti-relapse medications in alcoholism
    John M Littleton; Fiscal Year: 2010
  7. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    DIANE FEICKERT BIRT; Fiscal Year: 2010
  8. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
  9. Formulation Dependent Help Interactions with Chemothera*
    David Kroll; Fiscal Year: 2005
  10. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    Diane Birt; Fiscal Year: 2006

Detail Information

Publications285 found, 100 shown here

  1. ncbi Determining hyperforin and hypericin content in eight brands of St. John's wort
    Gerlie C de los Reyes
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Am J Health Syst Pharm 59:545-7. 2002
  2. ncbi Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells
    C M Schempp
    Department of Dermatology, Photodermatology Unit, University Medical Center, Haupstr 7, D 79104 Freiburg, Germany
    Br J Dermatol 142:979-84. 2000
    St John's wort (Hypericum perforatum) is a traditional herbal medicine that is used for the topical treatment of superficial wounds, burns and dermatitis...
  3. ncbi [Biologically active substances isolated from Hypericum attenuatum Choisy]
    O Iu Makovets'ka
    M M Grishko National Botanical Garden, NAS of Ukraine, Kiev
    Ukr Biokhim Zh 72:110-3. 2000
    ..two reductive forms of anthraquinones and five flavonoids have been isolated from the plant source Hypericum attenuatum Choisy (Guttiferae) firstly investigated for these substances contents...
  4. ncbi Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials
    S Kasper
    Department of Psychiatry und Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, 1090, Austria
    Eur Arch Psychiatry Clin Neurosci 258:59-63. 2008
    ..The analysis shows that St. John's wort extract WS 5570 has a meaningful beneficial effect during acute treatment of patients suffering from mild depression and leads to a substantial increase in the probability of remission...
  5. ncbi St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
    J Barnes
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London
    J Pharm Pharmacol 53:583-600. 2001
    ....
  6. ncbi Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro
    Yanping Zou
    State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, 200237, China
    J Agric Food Chem 52:5032-9. 2004
    A flavonoid-rich extract of Hypericum perforatum L. (FEHP) was prepared by adsorption on macroporous resin and desorption by ethanol. Total flavonoid content of FEHP was determined by a colorimetric method...
  7. ncbi Antimicrobial activity of some Hypericum species
    R Dall'agnol
    Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, RS, Brazil
    Phytomedicine 10:511-6. 2003
    The crude methanolic extracts of six species of Hypericum [H. caprifoliatum Cham. & Schlecht., H. carinatum Griseb., H. connatum Lam., H. ternum A. St. Hil., H. myrianthum Cham. & Schlecht. and H...
  8. pmc Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Malar J 10:167. 2011
    ..A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark.
  9. ncbi Contrasting plant physiological adaptation to climate in the native and introduced range of Hypericum perforatum
    John L Maron
    Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA
    Evolution 61:1912-24. 2007
    ..We determined the extent to which native and introduced populations of St. John's Wort (Hypericum perforatum) are genetically differentiated with respect to leaf-level morphological and physiological traits ..
  10. ncbi Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system
    O Grundmann
    College of Pharmacy, Department of Pharmaceutics, University of Florida, PO Box 100494, Gainesville, FL 32610, USA
    Neuropharmacology 58:767-73. 2010
    ..Our data provide new evidence for the hypothesis that the mechanism of action of STW3-VI is mediated by the interrelationship between the immune, oxidative defense and neuroendocrine system...
  11. ncbi Evidence for the enemy release hypothesis in Hypericum perforatum
    Montserrat Vila
    Centre de Recerca Ecològica i Aplicacions Forestals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Oecologia 142:474-9. 2005
    ..this prediction by comparing herbivore pressure on native European and introduced North American populations of Hypericum perforatum (St John's Wort)...
  12. ncbi Hepatoprotective effect of Hypericum japonicum extract and its fractions
    Ning Wang
    Guangzhou Quality R and D Center of Traditional Chinese Medicine, School of Life Science, Sun Yat Sen University, Guangzhou 510275, PR China
    J Ethnopharmacol 116:1-6. 2008
    To investigate the hepatoprotective activity of different parts of Hypericum japonicum against carbon tetrachloride(CCl(4))-induced hepatitis and alpha-naphthyl-isothiocyanate (ANIT)-induced cholestasis.
  13. ncbi Association between patient beliefs regarding assigned treatment and clinical response: reanalysis of data from the Hypericum Depression Trial Study Group
    Justin A Chen
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, Boston, USA
    J Clin Psychiatry 72:1669-76. 2011
    To reanalyze data from a 2002 study by the Hypericum Depression Trial Study Group to determine whether patients who believed they were receiving active therapy rather than placebo obtained greater improvement, independent of treatment.
  14. ncbi In vitro cytotoxicity and antitumour properties of Hypericum mysorense and Hypericum patulum
    P Vijayan
    J S S College of Pharmacy, Rocklands, Ootacamund 643 001, Tamilnadu, India
    Phytother Res 17:952-6. 2003
    The methanol extracts of the aerial parts of Hypericum mysorense and Hypericum patulum were tested for in vitro cytotoxicity on HEp-2, RD and Vero cell lines and antitumour activity using DLA and HEp-2 cell lines...
  15. pmc Attractive and defensive functions of the ultraviolet pigments of a flower (Hypericum calycinum)
    M Gronquist
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 98:13745-50. 2001
    The flower of Hypericum calycinum, which appears uniformly yellow to humans, bears a UV pattern, presumably visible to insects...
  16. ncbi p27(SJ), a novel protein in St John's Wort, that suppresses expression of HIV-1 genome
    N Darbinian-Sarkissian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Gene Ther 13:288-95. 2006
    ..Here, we describe the identification of a novel protein, p27(SJ), present in a laboratory callus culture of Hypericum perforatum (St John's Wort) that suppresses transcription of the HIV-1 genome in several human cell types ..
  17. ncbi Antifungal activity of some Brazilian Hypericum species
    R Fenner
    Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Porto Alegre 90610 000, Brazil
    Phytomedicine 12:236-40. 2005
    Crude methanolic extracts and fractions from the aerial parts of seven species of Hypericum (H. caprifoliatum Cham. and Schltdl., H. carinatum Griseb., H. connatum Lam., H. ternum A. St.-Hil., H. myrianthum Cham. and Schltdl., H...
  18. ncbi Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract
    Nicolas Singewald
    Department of Pharmacology and Toxicology, Institute of Pharmacy and CMBI, Leopold Franzens University of Innsbruck, Peter Mayr Str 1, A 6020 Innsbruck, Austria
    Neuropharmacology 47:1189-97. 2004
    ..Chronic oral administration of desipramine (30 mg/kg/day), or Hypericum extract LI160 (Hyp, 380 mg/kg/day) prevented the "pro-depression-like" forced swim behavior in Mg-depleted mice...
  19. ncbi Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract
    Filippo Caraci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Curr Drug Metab 12:570-7. 2011
    ..of depression in cancer patients, such as second-generation antidepressants and, recently, the extracts of Hypericum perforatum. These agents are susceptible to metabolically-based drug interactions with anticancer drugs...
  20. ncbi Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study
    M Gastpar
    General Psychiatric Hospital, Department of Psychiatry and Psychotherapy, University of Essen, Essen, Germany
    Pharmacopsychiatry 39:66-75. 2006
    ..placebo-controlled, multicentre clinical study was to demonstrate the non-inferiority and safety of the hypericum extract STW3-VI in a once-daily dosage regime in the treatment of moderate depression...
  21. pmc Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    AAPS J 11:710-27. 2009
    St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g...
  22. ncbi The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
    Z Wang
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Pharmacol Ther 70:317-26. 2001
    BACKGROUND: St John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and herbal remedy that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes...
  23. pmc Evidence for phosphatase activity of p27SJ and its impact on the cell cycle
    Nune Darbinian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 107:400-7. 2009
    p27SJ, a novel protein isolated from St John's wort (Hypericum perforatum), belongs to an emerging family of DING proteins that are related to a prokaryotic phosphate-binding protein superfamily...
  24. ncbi Herbal and dietary supplements for treatment of anxiety disorders
    Sy Atezaz Saeed
    Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Am Fam Physician 76:549-56. 2007
    ..Although the evidence varies depending on the supplement and the anxiety disorder, physicians can collaborate with patients in developing dietary supplement strategies that minimize risks and maximize benefits...
  25. ncbi The effect of ethanol extract of Hypericum lysimachioides on lipid profile in hypercholesterolemic rabbits and its in vitro antioxidant activity
    Fidan Hakimoğlu
    University of Dicle, Faculty of Science and Art, Chemistry Department, 21280 Diyarbakir, Turkey
    Atherosclerosis 192:113-22. 2007
    ..Realizing the fact that, this study was carried out to determine the effect of ethanol extract of Hypericum lysimachioides Boiss var lysimachioides (Guttifera) on serum lipid levels and serum lipid peroxidation in ..
  26. pmc Creation of a bi-directional protein transduction system for suppression of HIV-1 expression by p27SJ
    Nune Darbinian
    Department of Neuroscience, Temple University School of Medicine, 1900 North 12th Street, 015 96, Room 203, Philadelphia, PA 19122, United States
    Antiviral Res 79:136-41. 2008
    ..Furthermore, our results support the utility of soluble p27SJ in suppressing transcription and replication of HIV-1 by interfering with the function of cellular proteins such as C/EBPbeta and viral activators including Tat...
  27. ncbi Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins
    Katja Karppinen
    Department of Biology, University of Oulu, Finland
    FEBS J 275:4329-42. 2008
    Hypericins are biologically active constituents of Hypericum perforatum (St John's wort)...
  28. ncbi St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature
    J M Greeson
    Center for Integrative Medicine, Thomas Jefferson University Hospital, Jefferson Medical College, Philadelphia, PA 19107 6799, USA
    Psychopharmacology (Berl) 153:402-14. 2001
    St. John's wort (Hypericum perforatum) has recently gained popularity as an alternative treatment for mild to moderate depression...
  29. ncbi St John's wort (Hypericum perforatum) diminishes cognitive impairment caused by the chronic restraint stress in rats
    Emil Trofimiuk
    Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15 274 Bialystok, Poland
    Pharmacol Res 51:239-46. 2005
    In this study we tested the hypothesis that St John's wort (Hypericum perforatum) may counteract stress-induced memory impairment. Object recognition test and Morris water maze were used to determine whether administration of H...
  30. ncbi Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines
    Katarina Hostanska
    Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Pharm Biopharm 56:121-32. 2003
    ..Cytocidal effects of HP and its cooperation with HY on tumor growth inhibition in a synergistic manner make the St John's wort an interesting option in cancer warranting further in vitro and in vivo investigation...
  31. ncbi Phytochemical analysis of nine Hypericum L. species from Serbia and the F.Y.R. Macedonia
    A Smelcerovic
    Institute of Environmental Research, University of Dortmund, Germany
    Pharmazie 61:251-2. 2006
    The methanol extracts of the aerial parts of nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. maculatum, H. olympicum, H. perforatum, H. richeri, H. rumeliacum and H...
  32. pmc Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial
    Wendy Weber
    School of Naturopathic Medicine, Bastyr University, Kenmore, Washington, USA
    JAMA 299:2633-41. 2008
    Stimulant medication can effectively treat 60% to 70% of youth with attention-deficit/hyperactivity disorder (ADHD). Yet many parents seek alternative therapies, and Hypericum perforatum (St John's wort) is 1 of the top 3 botanicals used.
  33. ncbi Metal content monitoring in Hypericum perforatum pharmaceutical derivatives by atomic absorption and emission spectrometry
    María R Gomez
    Universidad Nacional de San Luis, Facultad de Quimica, Bioquimica y Farmacia, Chacabuco y Pedernera, San Luis 5700, Argentina
    J Pharm Biomed Anal 34:569-76. 2004
    ..measurable amounts of Ca, Cu, K, Li, Mg, Mn, Na, Ni, and Zn were detected in phytopharmaceutical derivatives of Hypericum perforatum by atomic techniques...
  34. ncbi Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test
    Michael Nöldner
    Department of Pharmacology and Phytochemistry, Dr Willmar Schwabe Pharmaceuticals, Karlsruhe, Germany
    Planta Med 68:577-80. 2002
    It has been shown that aqueous alcoholic extracts of Hypericum perforatum (St. John's wort) are active in the forced swimming test (FST), an animal model for antidepressant activity...
  35. ncbi Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism
    J De Vry
    CNS Research, Bayer AG, Wuppertal, Germany
    Eur Neuropsychopharmacol 9:461-8. 1999
    Clinical evidence suggests that hypericum extracts (Hypericum perforatum L., St. John's wort) have antidepressive properties and may offer an interesting alternative for the treatment of mood disorders...
  36. ncbi Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models
    Bernd L Fiebich
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Fitoterapia 82:474-80. 2011
    Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone...
  37. ncbi Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study
    Andrea Sardella
    Unit of Oral Pathology and Medicine, School of Dentistry, University of Milan, Milan, Italy
    J Oral Pathol Med 37:395-401. 2008
    ..This double-blind, randomized, placebo-controlled, single-center study evaluated the effects of systemic Hypericum perforatum extract in patients with BMS...
  38. pmc De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites
    Miao He
    Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 7:e42081. 2012
    b>Hypericum perforatum L. (St. John's wort) is a medicinal plant with pharmacological properties that are antidepressant, anti-inflammatory, antiviral, anti-cancer, and antibacterial...
  39. ncbi Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum Thunb
    Hyung In Moon
    Inam Neuroscience Research Center, Wonkwang University, Sanbon Medical Center, Kyunggi Do, South Korea
    Phytother Res 24:941-4. 2010
    The chloroform extracts of whole plants of Hypericum erectum were investigated for antiplasmodial activity against chloroquine-sensitive strains of Plasmodium falciparum...
  40. ncbi Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense
    Naonobu Tanaka
    Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
    J Nat Prod 72:1447-52. 2009
    ..compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-..
  41. ncbi Phytochemical analysis and genetic characterization of six Hypericum species from Serbia
    Andrija Smelcerovic
    Institute of Environmental Research, University of Dortmund, Otto Hahn Str 6, 44221 Dortmund, Germany
    Phytochemistry 67:171-7. 2006
    The secondary metabolite contents and genetic profiles of six Hypericum species (H. barbatum Jacq., H. hirsutum L., H. linarioides Bosse, H. maculatum Crantz, H. rumeliacum Boiss. and H...
  42. pmc An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
    Khadijo Osman
    Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK
    Int J Antimicrob Agents 39:124-9. 2012
    ..hyperenone A and hypercalin B were isolated from the hexane and chloroform extracts of the aerial parts of Hypericum acmosepalum...
  43. ncbi Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats
    M Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino (MC, Italy
    Alcohol Alcohol 36:199-206. 2001
    b>Hypericum perforatum extracts (HPE) inhibit ethanol intake in rats. Hypericin and hyperforin have been proposed as major active principles of HPE...
  44. ncbi Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo
    Patrícia Valentão
    Department of Pharmacognosy, University of Porto, Rua Anibal Cunha, 4050 047, Portugal
    J Ethnopharmacol 94:345-51. 2004
    ..The aim of the present study was to evaluate the putative protective effect of Hypericum androsaemum lyophilised infusion against t-BHP-induced mice hepatotoxicity in vivo, which has already been shown ..
  45. ncbi The first prenylation step in hyperforin biosynthesis
    Zakia Boubakir
    Institut fuer Pharmazeutische Biologie, Technische Universitaet Braunschweig, Mendelssohnstr 1, D 38106 Braunschweig, Germany
    Phytochemistry 66:51-7. 2005
    ..include hyperforin which is both quantitatively and pharmacologically a major constituent of the medicinal plant Hypericum perforatum (St. John's wort)...
  46. ncbi St. John's wort - an overview
    Klaus Linde
    Centre for Complementary Medicine Research, Department for Internal Medicine II, Technical University of Munich, Germany
    Forsch Komplementmed 16:146-55. 2009
    This article aims to summarize the current state of knowledge on St. John's wort (Hypericum perforatum L.) which is one of the oldest and best investigated medicinal herbs...
  47. ncbi Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice
    C C Sánchez-Mateo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de La Laguna, c Astrofísico Francisco Sánchez s n, 38071 La Laguna, Tenerife, Spain
    J Ethnopharmacol 112:115-21. 2007
    ..previously reported that oral administration of the methanol extract obtained from the aerial part in blossom of Hypericum reflexum L. fil. was active in the tetrabenazine and forced swimming test...
  48. ncbi Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort)
    S G von Eggelkraut-Gottanka
    Department of Pharmaceutical Technology, Auf der Morgenstelle 8, D 72076 Tubingen, Germany
    Phytochem Anal 13:170-6. 2002
    The major components of eight different batches of commercially available dry extracts of Hypericum perforatum L. were quantified...
  49. ncbi Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells
    Yan Ping Zou
    Department of Cereal and Food Science, North Dakota State University, Fargo, North Dakota 58105, USA
    Phytother Res 24:S6-S10. 2010
    b>Hypericum perforatum L. has been used traditionally as an antidepressant for the treatment of mild to moderate depression. In a previous study, a flavonoid-rich extract of Hypericum perforatum L...
  50. ncbi Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, via Scalino 3, 62032 Camerino MC, Italy
    Alcohol Alcohol 40:291-6. 2005
    Extracts of Hypericum perforatum (HPE) attenuate voluntary ethanol intake in different lines of alcohol-preferring rats...
  51. ncbi Investigations on the in vivo wound healing potential of Hypericum perforatum L
    Ipek Peşin Süntar
    Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, Etiler 06330, Ankara, Turkey
    J Ethnopharmacol 127:468-77. 2010
    Olive oil extract of the flowering aerial parts of Hypericum perforatum L. (Hypericaceae) is a popular folk remedy for the treatment of wounds in Turkey.
  52. ncbi Sulfonated xanthones from Hypericum sampsonii
    Di Hong
    Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China
    Phytochemistry 65:2595-8. 2004
    ..sampsonii. This is the first report of sulfonated xanthonoids. Furthermore, compounds 1 and 2 exhibited significant cytotoxicity against the P388 cancer cell line...
  53. ncbi Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino Macerata, Italy
    Alcohol Clin Exp Res 27:1554-62. 2003
    b>Hypericum perforatum extracts attenuate ethanol intake in alcohol-preferring rats. The opioid receptor antagonists, naloxone and naltrexone, reduce ethanol intake in rats and humans...
  54. ncbi Hypericum extract LI 160 and fluoxetine in mild to moderate depression: a randomized, placebo-controlled multi-center study in outpatients
    Lars Bjerkenstedt
    Department of Clinical Neuroscience, Psychiatry Section Karolinska Hospital, 17176, Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 255:40-7. 2005
    Efficacy and tolerability of Hypericum LI 160 was compared to fluoxetine and placebo in mild to moderate Major Depression (DSM-IV) in a 4-week randomized, double-blind trial...
  55. ncbi Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts
    Miris Dikmen
    Anadolu University, Faculty of Pharmacy, Department of Pharmacology, Eskisehir, Turkey
    Phytother Res 25:208-14. 2011
    For centuries, Hypericum perforatum has been used in folk medicine to treat wounds. In the present study, the wound healing activities of extracts of H. perforatum ssp. perforatum (HPP) and H. perforatum ssp...
  56. ncbi Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers
    Hans Ulrich Schulz
    LAFAA Laboratory for Contract Research in Clinical Pharmacology and Biopharmaceutical Analytics GmbH, Bad Schwartau, Germany
    Arzneimittelforschung 55:561-8. 2005
    ..John's wort (Hypericum perforatum)...
  57. ncbi Xanthones from Hypericum chinense and their cytotoxicity evaluation
    Naonobu Tanaka
    Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
    Phytochemistry 70:1456-61. 2009
    A xanthonolignoid, 2-O-demethylkielcorin, and a phenylxanthone, chinexanthone A, were isolated from stems of Hypericum chinense together with four known xanthonolignoids and seven known xanthones...
  58. ncbi Antimicrobial studies on three species of Hypericum from the Canary Islands
    R M Rabanal
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de La Laguna, 38071 La Laguna, Tenerife, Spain
    J Ethnopharmacol 81:287-92. 2002
    The antimicrobial activity of several extracts and fractions of the aerial parts of Hypericum canariense, Hypericum glandulosum and Hypericum grandifolium was investigated using the disc diffusion and broth microdilution methods against ..
  59. ncbi Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample
    Ricardo Alberto Moreno
    Institute of Psychiatry, Clinical Hospital, Medical School, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 28:29-32. 2006
    b>Hypericum perforatum has demonstrated antidepressant efficacy when compared to placebo, but comparisons with other antidepressants remain controversial...
  60. ncbi Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium--possible mechanism of action
    Arif Ullah Khan
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 24:1027-32. 2010
    The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1...
  61. ncbi Efficacy and tolerability of hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline
    M Gastpar
    General Psychiatric Hospital, Dept of Psychiatry and Psychotherapy, University of Essen, Germany
    Pharmacopsychiatry 38:78-86. 2005
    The objective of this double-blind, multi-center clinical study was to demonstrate the non-inferiority of hypericum extract versus sertraline in the treatment of moderate depression.
  62. ncbi SNP-mediated neuroprotection under glucose deprivation is enhanced by Hypericum perforatum
    Maria Munoz
    Departamento de Farmacologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    CNS Neurol Disord Drug Targets 11:162-73. 2012
    b>Hypericum perforatum is a medicinal herb possessing ability for protecting neurons from oxidative stress...
  63. pmc Effects of Hypericum Perforatum, in a rodent model of periodontitis
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    BMC Complement Altern Med 10:73. 2010
    b>Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis.
  64. ncbi A study of the antidepressant activity of Hypericum perforatum on animal models
    C Gambarana
    Department of Neuroscience, University of Siena, Italy
    Pharmacopsychiatry 34:S42-4. 2001
    The treatment of non-selected depressed patients with a hydro-alcoholic extract of Hypericum perforatum has been reported to have an efficacy similar to that of classical antidepressants. The effects of H...
  65. ncbi Molecular identification of Hypericum perforatum by PCR amplification of the ITS and 5.8S rDNA region
    Caroline Howard
    School of Allied Health Sciences, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK
    Planta Med 75:864-9. 2009
    The nuclear ribosomal internal transcribed spacer (ITS) sequences of eight Hypericum species were used to design H. perforatum-specific PCR primers by identification of short "microcode" sequences characteristic of the target species...
  66. ncbi Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation
    C Moschella
    Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Kidney Dis 38:1105-7. 2001
    The use of herbal medicine has become increasingly popular in the United States. Hypericum perforatum (St. John's wort) is an herbal extract that is used widely as a folk remedy for depression...
  67. ncbi Evaluation of the central properties of several Hypericum species from the Canary Islands
    Begoña Prado
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de La Laguna, c Astrofísico Francisco Sánchez s n, 38071, La Laguna, Tenerife, Espana
    Phytother Res 16:740-4. 2002
    The infusions of the aerial parts in blossom of Hypericum canariense, H. glandulosum, H. reflexum and H...
  68. ncbi The cytohistological basis of apospory in Hypericum perforatum L
    G Galla
    Department of Environmental Agronomy and Crop Science, Laboratory of Plant Genetics and Genomics, University of Padova, Legnaro, Italy
    Sex Plant Reprod 24:47-61. 2011
    St. John's wort (Hypericum perforatum L., 2n = 4x = 32) is a medicinal plant that produces pharmaceutically important metabolites with antidepressive, anticancer and antiviral activities...
  69. ncbi Acaricidal properties of extracts from the aerial parts of Hypericum polyanthemum on the cattle tick Boophilus microplus
    Vera Lucia Sardá Ribeiro
    Laboratorio de Entomologia, Faculdade de Veterinaria, UFRGS, Av Bento Goncalves 9090, 91540 000 Porto Alegre, RS, Brazil
    Vet Parasitol 147:199-203. 2007
    ..of the cattle tick Boophilus microplus to determine the toxicity of n-hexane and crude methanolic extracts of Hypericum polyanthemum (Guttiferae) using the larval immersion test (LIT) and adult immersion test (AIT)...
  70. ncbi Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress
    Gregory Franklin
    Departamento de Biologia, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Phytochemistry 70:60-8. 2009
    Xanthone production in Hypericum perforatum (HP) suspension cultures in response to elicitation by Agrobacterium tumefaciens co-cultivation has been studied. RNA blot analyses of HP cells co-cultivated with A...
  71. ncbi St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro
    Christiana Winkler
    Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Biol Chem 385:1197-202. 2004
    St. John's wort (Hypericum perforatum) is an ancient folk remedy that has antiviral and antibacterial properties. Anti-inflammatory effects of the plant have been described and the application of H...
  72. ncbi Phenolic compounds from Hypericum perforatum
    Guido Jürgenliemk
    Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhelms University of Münster, Germany
    Planta Med 68:88-91. 2002
    During a re-investigation of phenolic compounds from the dried crude drug material of St. John's wort (Hypericum perforatum L.) 22 phenolic compounds were detected by HPLC; 14 of them were quantified using the same system...
  73. ncbi Biosynthesis of the hyperforin skeleton in Hypericum calycinum cell cultures
    Petra Klingauf
    Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Phytochemistry 66:139-45. 2005
    Hyperforin is an important antidepressant constituent of Hypericum perforatum (St. John's wort). Cell cultures of the related species H...
  74. ncbi Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity
    A G Jensen
    The Royal Danish School of Pharmacy, Department of Analytical and Pharmaceutical Chemistry, Copenhagen
    Life Sci 68:1593-605. 2001
    ..which demonstrate that hyperforin is not the only phloroglucinol derivative in extracts of the medicinal plant Hypericum perforatum L., which possess a biological activity...
  75. ncbi Duration of response after treatment of mild to moderate depression with Hypericum extract STW 3-VI, citalopram and placebo: a reanalysis of data from a controlled clinical trial
    A Singer
    Pierrel Research Onco Immunology GmbH, Wiesbaden, Germany
    Phytomedicine 18:739-42. 2011
    St. John's Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression...
  76. ncbi Effects of Hypericum perforatum (St. John's wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity
    I Misane
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Pharmacopsychiatry 34:S89-97. 2001
    Along with traditional pharmacotherapies, extracts of Hypericum perforatum L. (St. John's wort) are used in the treatment of mild to moderately severe depression...
  77. ncbi Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae)
    A F Viana
    Laboratorio de Psicofarmacologia, Departamento de Produção de Matéria Prima, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 36:631-4. 2003
    The aim of the present study was to assess the analgesic activity of the aerial parts of two Hypericum species native to Southern Brazil, H. caprifoliatum and H. polyanthemum. The antinociceptive effect of the H...
  78. ncbi [Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method]
    Saulius Kazlauskas
    Kaunas University of Medicine, A Mickeviciaus 9, 44307 Kaunas, Lithuania
    Medicina (Kaunas) 40:975-81. 2004
    ..John's wort (Hypericum perforatum)...
  79. ncbi Hypericum perforatum L. and Chamomilla recutita (L.) Rausch.--accumulators of some toxic metals
    K Král'ová
    Institute of Chemistry, Comenius University, Bratislava, Slovakia
    Pharmazie 58:359-60. 2003
  80. ncbi Genetic and biochemical analysis of Hypericum perforatum L. plants regenerated after cryopreservation
    Martina Urbanova
    Institute of Biology and Ecology, Faculty of Science, P J Safarik University, Manesova 23, 04154 Kosice, Slovakia
    Plant Cell Rep 25:140-7. 2006
    Shoot-tips from in vitro cultured Hypericum perforatum L. genotypes were subjected to assessments of developmental competence, genetic stability, and biosynthetic ability to identify critical points during cryopreservation...
  81. ncbi Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L.) grown in controlled environments
    Melissa L Brechner
    Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA
    Photochem Photobiol 87:680-4. 2011
    ..St. John's wort (Hypericum perforatum) is a popular herbal remedy which also exhibits marked variance in AI concentration among products...
  82. ncbi Serotonin syndrome and rhabdomyolysis induced by concomitant use of triptans, fluoxetine and hypericum
    N Bonetto
    Department of Neuroscience, University of Padova Medical School, Padova, Italy
    Cephalalgia 27:1421-3. 2007
  83. ncbi Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum )
    Andreas Johne
    Institute of Clinical Pharmacology, University Medical Center Charite, Humboldt University of Berlin, Berlin, Germany
    J Clin Psychopharmacol 22:46-54. 2002
    Extracts of St. John's wort ( Hypericum perforatum ) became increasingly popular as easily available remedies for mild to moderate depression...
  84. ncbi Hypericum triquetrifolium Turra. Extract exhibits antiinflammatory activity in the rat
    Bintug Ozturk
    Department of Pharmaceutical Botany, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey
    J Ethnopharmacol 80:207-9. 2002
    The aim of the present study was to explore the probable antiinflammatory effect of Hypericum triquetrifolium Turra. in a rat model of carrageenan induced inflammation. Male Wistar rats were treated intraperitoneally with 0...
  85. ncbi St John's wort (Hypericum perforatum) in major depression
    Richard C Shelton
    Department of Psychiatry, Mood Disorders Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Psychiatry 70:23-7. 2009
    The herb St John's wort (Hypericum perforatum) has been used for centuries to treat a variety of medical illnesses...
  86. ncbi Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum
    Katja Karppinen
    Department of Biology, University of Oulu, P O Box 3000, FIN 90014 Oulu, Finland
    Phytochemistry 68:1038-45. 2007
    Hyperforin and adhyperforin contribute to the antidepressant effects of Hypericum perforatum. The involvement of branched-chain amino acids in the biosynthesis of hyperforin and adhyperforin was demonstrated in H...
  87. ncbi Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS
    Anna Piovan
    Department of Biology, Padua University, Via U Bassi 58 B, 35131 Padua, Italy
    Phytochemistry 65:411-4. 2004
    ..were detected by electrospray ionization mass spectrometry (ESI-MS/MS) in microsamples from the sepals of Hypericum elodes (Hypericaceae) containing the so-called "red glands", i.e...
  88. ncbi The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice
    Lidija Bach-Rojecky
    Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10 000 Zagreb, Croatia
    Acta Pharm 54:157-62. 2004
    ..b>Hypericum perforatum L. (St. John's wort) is the only natural antidepressant...
  89. ncbi Evaluation of the analgesic and topical anti-inflammatory effects of Hypericum reflexum L. fil
    C C Sánchez-Mateo
    Departamento de Medicina Física y Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain
    J Ethnopharmacol 107:1-6. 2006
    ..anti-inflammatory effects of the infusion, methanol extract and fractions of the aerial part in blossom of Hypericum reflexum L. fil. in mice...
  90. ncbi Morphological, histochemical and phytochemical investigation of the genus Hypericum of the Central Italy
    F Maggi
    Department of Botany and Ecology, UNICAM, Via Pontoni 5, I 62032 Camerino, Italy
    Fitoterapia 75:702-11. 2004
    Eight entities of the genus Hypericum that spontaneously grow on the Central Italy (Appennino Umbro-Marchigiano) have been studied under the morphological, histochemical and phytochemical aspects...
  91. ncbi Hypericum caprifoliatum (Guttiferae) Cham. & Schltdl.: a species native to South Brazil with antidepressant-like activity
    Alice F Viana
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul Av Ipiranga, 2752 Porto Alegre, RS, Brazil
    Fundam Clin Pharmacol 20:507-14. 2006
    In this work, previously published and unpublished results on biological activity of Hypericum caprifoliatum, a native species to South Brazil, are presented...
  92. pmc Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI
    Stella Bitran
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, USA
    Int Clin Psychopharmacol 26:206-12. 2011
    ..in Hamilton Depression Rating Scale-17 anxiety/somatization items predict remission in two controlled studies of Hypericum perforatum (St John's wort) versus selective serotonin reuptake inhibitors for major depressive disorder...
  93. ncbi Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort)
    Travis S Walker
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins 80523 1173, USA
    Phytochemistry 60:289-93. 2002
    b>Hypericum perforatum L. (St. John's wort) is an herbal remedy widely used in the treatment of mild to moderate depression...
  94. ncbi Phenolic constituents and the in vitro antioxidant activity of the flowers of Hypericum venustum
    Michael Spiteller
    Institute of Environmental Research, University of Dortmund, Otto Hahn Str 6, 44221 Dortmund, Germany
    Fitoterapia 79:191-3. 2008
    The phenolic constituents and antioxidant activity of ethanol and water extract of the flowers of Hypericum venustum, collected in Turkey, were investigated...
  95. ncbi Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells
    Juana Benedi
    Departamento de Farmacologia, Facultad de Farmacia, Universidad Complutense, Plaza Ramon y Cajal sn 28040 Madrid, Spain
    Life Sci 75:1263-76. 2004
    Free radical scavenging and antioxidant activities of a standardized extract of Hypericum perforatum (SHP) were examined for inhibition of lipid peroxidation, for hydroxyl radical scavenging activity and interaction with 1,1-diphenyl-2-..
  96. ncbi Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Int J Clin Pharmacol Ther 42:139-48. 2004
    St. John's Wort (SJW, Hypericum perforatum) is effective in mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile...
  97. ncbi Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense
    Wei Wang
    School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    J Nat Prod 73:1815-20. 2010
    ..the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis...
  98. ncbi Inhibitory effects of flavonoids from Hypericum perforatum on nitric oxide synthase
    L Luo
    Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China
    J Ethnopharmacol 93:221-5. 2004
    The inhibitory effects of six flavonoids from Hypericum perforatum were assessed spectrophotometrically using nitric oxide synthase (NOS) in blood and cerebral homogenate of rats...
  99. ncbi Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
    Siegfried Kasper
    Department of General Psychiatry, Medical University of Wien, MUV, Austria
    Eur Neuropsychopharmacol 20:747-65. 2010
    ..Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression...
  100. pmc Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice
    Anil Kumar
    Pharmacology Division, UGC Centre of Advance Study, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    BMC Complement Altern Med 10:18. 2010
    ..The present study was designed to investigate the effect of St. John's Wort (Hypericum perforatum) in restraint stress-induced behavioral and biochemical alterations in mice.
  101. ncbi HPLC-MS analysis and anti-oedematogenic activity of Hypericum grandifolium Choisy (Hypericaceae)
    Celia X Bonkanka
    Department of Pharmacology, Faculty of Pharmacy, University of La Laguna, La Laguna, Tenerife, Spain
    Planta Med 74:719-25. 2008
    ..been carried out on the chemical composition and in vivo anti-oedematogenic activity of several extracts from Hypericum grandifolium Choisy (Hypericaceae) collected in Tenerife (Canary Islands)...

Research Grants61

  1. Botanical Treatments in Social Anxiety Disorder
    Kathryn Connor; Fiscal Year: 2005
    ..In the first study, 56 GSAD subjects will be randomly assigned to double-blind treatment with either Hypericum perforatum (HYP) or placebo (PBO), up to 1800 mg/day, for 10 weeks...
  2. R21 Project: St. John's Wort vs. Placebo in OCD
    Kenneth Kobak; Fiscal Year: 2003
    ..There has been considerable worldwide interest in St. John's Wort (SJW) (Hypericum perforatum) as a treatment from mild to moderate depression...
  3. St. John's wort for Drug Abuse Treatment During Pregnancy
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2012
    ..The results will be a test of a novel pharmacological strategy for treatment of pregnant women with opioid dependence/addiction. ..
  4. Botanicals and Metabolic Syndrome
    William T Cefalu; Fiscal Year: 2013
    ..Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action...
  5. Mood Disorders Clincal Intervention Training Program
    Madhukar H Trivedi; Fiscal Year: 2013
    ..has established track records in the study of a wide array of interventions including ECT, cognitive therapy, hypericum, antidepressant medications, exercise, and the combination of medications and psychotherapy...
  6. Hypericum extracts as potential anti-relapse medications in alcoholism
    John M Littleton; Fiscal Year: 2010
    ..In this regard, the extracts of "St John's Wort", (Hypericum perforatum) that are effective treatments for clinical depression (see 2) also inhibit alcohol consumption in ..
  7. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    DIANE FEICKERT BIRT; Fiscal Year: 2010
    ..immune and anti-viral properties of extracts from two of the most extensively used botanicals, Echinacea and Hypericum (St. John's Wort)...
  8. Herb-Opioid Interactions
    Danny Shen; Fiscal Year: 2003
    DESCRIPTION (provided by applicant):Extract of SJW; Hypericum perforatum, has gained widespread popularity as an over-the-counter, natural antidepressant. Until recently, SJW was thought to be well tolerated and relatively safe...
  9. Formulation Dependent Help Interactions with Chemothera*
    David Kroll; Fiscal Year: 2005
    ..John's wort (SJW), Hypericum perforatum...
  10. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    Diane Birt; Fiscal Year: 2006
    ..We have chosen to study Echinacea and hypericum becase they are two of the most commonly used herbs by consumers in the united States; there is substantial ..
  11. St. John's Wort vs Placebo in Social Phobia
    Kenneth Kobak; Fiscal Year: 2002
    ..There has been considerable worldwide interest in St. John's Wort (SJW) (Hypericum perforatum) as a treatment of mild to moderate depression...
  12. Anti-edema and neuroprotective effects of Ginkgo extract EGb761 and bilobalide
    Jochen Klein; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Extracts of Ginkgo biloba and Hypericum perforatum (St...
  13. PILOT STUDY OF ST JOHNS WORT IN JUVENILE DEPRESSION
    Robert Findling; Fiscal Year: 1999
    ..The extract from the plant Hypericum perforatum is commonly referred to as St. John's Wort (SJW)...
  14. ANTI-HIV ACTIVITY OF BOTANICAL PREPARATIONS
    CYNTHIA WENNER; Fiscal Year: 2001
    ..Botanical preparations of Hypericum perforatum and Glycyrrhiza glabra were selected based on the prevalence of use of these botanicals in the HIV ..
  15. COORDINATING CENTER FOR CLINICAL TRIAL OF HYPERICUM
    Jonathan Davidson; Fiscal Year: 2000
    ..will be to conduct a three-arm, placebo controlled, clinical efficacy study of a standardized extract of hypericum in major depression...
  16. Identification of Hypericum using Microscopy and DNA
    MATTHEW CIMINO; Fiscal Year: 2004
    ..a practical means to identify and differentiate between small quantities of different species and types of Hypericum in various processed and partially processed forms...
  17. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  18. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  19. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  20. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  21. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  22. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  23. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
    ..John's wort (Hypericum perforatum)...
  24. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  25. Omega-3 Fatty Acids for Treatment of Major Depression
    David Mischoulon; Fiscal Year: 2010
    ..e. integrates biological findings with treatment in order to have a direct impact on the clinical practice of psychiatry. ..
  26. Omega-3 Fatty Acids in the Treatment of Depression
    David Mischoulon; Fiscal Year: 2005
    ..It is hoped that this project will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator. ..
  27. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  28. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ....
  29. St. John's Wort and CYP3A Metabolism in Men & Women
    Reginald Frye; Fiscal Year: 2003
    ..v. and oral midazolam administration (oral midazolam followed by i.v. at 6 hr after oral dosing) and comparing this to separate day administration of i.v. and oral midazolam (Specific Aim 3). ..
  30. Filovirus/cellular receptor interactions
    Wendy Maury; Fiscal Year: 2007
    ..Development of equivalent drugs for the filoviruses might prove to be successful in limiting new outbreaks. [unreadable] [unreadable]..
  31. ACUPUNCTURE TREATMENT OF DEPRESSION DURING PREGNANCY
    Rachel Manber; Fiscal Year: 2006
    ..Other important measures include the Beck Depression Inventory (weekly), expectations (of the participants and the providers), and delivery and infant measures. ..
  32. Effect of Cirrhosis and Shunts on Drug Disposition
    Stephen Hall; Fiscal Year: 2006
    ....
  33. VENLAFAXINE FOR HOT FLASHES FOLLOWING BREAST CANCER
    JANET CARPENTER; Fiscal Year: 2003
    ..e., t-tests, linear regression, GEE, mixed model). Study findings will significantly contribute to the scientific basis of hot flash management in women following treatment for breast cancer. ..
  34. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  35. Genetic epidemiology of irritable bowel syndrome (IBS)
    YURI SAITO LOFTUS; Fiscal Year: 2008
    ....
  36. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  37. Prediction of Drug-Drug Interactions
    Zeruesenay Desta; Fiscal Year: 2007
    ..The in vitro parameter estimates will be incorporated into our physiological pharmacokinetic models to test the predictive power and build a universal platform for complex interactions between chemicals. ..
  38. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
    ..In addition, this project will provide important insights into the relative contributions of testosterone and estrogen in bone metabolism, and maintenance of muscle size and strength in older men. ..
  39. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  40. Suppression of HIV-1 in CNS by a novel protein from ST John's Wort
    Shohreh Amini; Fiscal Year: 2010
    ..we build on our preliminary data indicating that a novel protein, p27SJ, derived from a callus culture of Hypericum perforatum (also known as St...
  41. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2009
    ..Moreover, since both FXR and ERbeta can be regulated by small molecule ligands, these studies may reveal novel opportunities for treating and preventing colon cancer. ..
  42. S-Adenosyl Methionine(SAMe)Augmentation of SSRIs in MDD
    George Papakostas; Fiscal Year: 2008
    ..It is hoped that this project award will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator in this area. ..
  43. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  44. MOLECULAR MECHANISMS OF 5-HT RECEPTOR ACTIONS
    Bryan Roth; Fiscal Year: 2005
    ..A full molecular pharmacologic characterization of these compounds is essential prior to their use in humans. ..
  45. Computerized Assessment of Cancer Symptoms
    JANET CARPENTER; Fiscal Year: 2005
    ....
  46. REGULATION OF CYTOKINES BY HIV1 TAT IN CENTRAL NERVOUS S
    Shohreh Amini; Fiscal Year: 2004
    ..These studies will provide information concerning the mechanism of CNS cellular gene activation by Tat, and may serve as an initial step toward the development of targeted therapeutic compounds against HIV-1 Tat in the CNS. ..
  47. TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)
    Robert Findling; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..
  48. Antidepressant & CBT for Insomnia to Depression Outcome
    Rachel Manber; Fiscal Year: 2006
    ..The findings from the proposed pilot study will inform the design of a subsequent full-scale randomized controlled trial. ..
  49. Controlled Trial of an Herbal Therapy for ADHD
    Wendy Weber; Fiscal Year: 2006
    ..Weber will conduct an eight-week double blind placebo controlled clinical trial of Hypericum perforatum (St. John's Wort) for the treatment of depression in children and adolescents aged 6 to 17...
  50. St. John's Wort Effects on Levonorgestrel
    Patricia Murphy; Fiscal Year: 2006
    ..John's Wort (Hypericum perforatum), on metabolism of levonorgestrel in a dosing regimen for emergency contraception...
  51. Regulation of Gliosis by Purinergic Receptor Signaling
    W Dalton Dietrich; Fiscal Year: 2006
    ..Thus, important advances in the understanding of the mechanisms underlying gliosis may provide new approaches to restore deficits in motor skills and cognitive functions caused by brain injury. [unreadable] [unreadable]..
  52. Identification of Hypericum using Microscopy and DNA
    MATTHEW CIMINO; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): [unreadable] Hypericum or St. John's Wort is a widely used herbal...
  53. Effects of Hypericum Perforatum on Oral Contraceptives
    Patricia Murphy; Fiscal Year: 2002
    This study will evaluate the effects of chronic use of a common herbal remedy, St. John's Wort (Hypericum perforatum) on metabolism of contraceptive steroids and ovarian suppression during oral contraceptive use. St...
  54. Dietary Supplements and Lung & Colorectal Cancer Risk
    Jessie Satia; Fiscal Year: 2006
    ..abstract_text> ..
  55. Diet, Colon Cancer, and Cancer Communications
    Jessie Satia; Fiscal Year: 2005
    ..Obtaining this award will greatly broaden and strengthen the candidate's focus on cancer prevention and control. ..
  56. Integrating Aging and Cancer Research
    Robert Wallace; Fiscal Year: 2007
    ..Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development. ..
  57. Antioxidant nutrients and Oxidative DNA Damage in Afric*
    Jessie Satia; Fiscal Year: 2005
    ..In addition, this work would potentially provide investigators with a validated instrument for assessing antioxidant nutrient exposure in population-based studies in the U.S. ..