tobacco

Summary

Summary: A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.

Top Publications

  1. ncbi An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus
    Olivier Voinnet
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant J 33:949-56. 2003
  2. ncbi Auxin inhibits endocytosis and promotes its own efflux from cells
    Tomasz Paciorek
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Nature 435:1251-6. 2005
  3. pmc Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults
    Jennifer M Kreslake
    Tobacco Control Research Program, Division of Public Health Practice, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA harvard edu
    Am J Public Health 98:1685-92. 2008
  4. pmc Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis
    H Jin
    John Innes Centre, Colney, Norwich NR4 7UH, Institute of Food Research, Colney, Norwich NR4 7UH, UK
    EMBO J 19:6150-61. 2000
  5. ncbi PIN proteins perform a rate-limiting function in cellular auxin efflux
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Science 312:914-8. 2006
  6. pmc Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10
    Richard V Espley
    HortResearch, Mt Albert Research Centre, Private Bag 92169, Auckland, New Zealand
    Plant J 49:414-27. 2007
  7. ncbi Virus-induced gene silencing in tomato
    Yule Liu
    Department of Molecular, Cellular and Developmental Biology, OML 451, Yale University, PO Box 208104, New Haven, CT 06520 8104, USA
    Plant J 31:777-86. 2002
  8. doi Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
    Giorgio Romagna
    Abich srl, biological and chemical toxicology research laboratory, Verbania VB, Italy
    Inhal Toxicol 25:354-61. 2013
  9. ncbi Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation
    Cyril Zipfel
    Botanical Institute, Zurich Basel Plant Science Centre, University of Basel, Hebelstrasse 1, CH 4056 Basel, Switzerland
    Cell 125:749-60. 2006
  10. ncbi Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation
    Michael Walter
    Institut fur Botanik und Botanischer Garten, Molekulare Entwicklungsbiologie der Pflanzen, Universitat Munster, Schlossplatz 4, 48149 Munster, Germany
    Plant J 40:428-38. 2004

Detail Information

Publications386 found, 100 shown here

  1. ncbi An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus
    Olivier Voinnet
    The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Plant J 33:949-56. 2003
    ....
  2. ncbi Auxin inhibits endocytosis and promotes its own efflux from cells
    Tomasz Paciorek
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Nature 435:1251-6. 2005
    ....
  3. pmc Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults
    Jennifer M Kreslake
    Tobacco Control Research Program, Division of Public Health Practice, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA harvard edu
    Am J Public Health 98:1685-92. 2008
    We examined whether tobacco manufacturers manipulate the menthol content of cigarettes in an effort to target adolescents and young adults.
  4. pmc Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis
    H Jin
    John Innes Centre, Colney, Norwich NR4 7UH, Institute of Food Research, Colney, Norwich NR4 7UH, UK
    EMBO J 19:6150-61. 2000
    ..It belongs to a novel group of plant R2R3 MYB proteins involved in transcriptional silencing. The balance between MYB activators and repressors on common target promoters may provide extra flexibility in transcriptional control...
  5. ncbi PIN proteins perform a rate-limiting function in cellular auxin efflux
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Science 312:914-8. 2006
    ..Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGP, rate-limiting, specific to ..
  6. pmc Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10
    Richard V Espley
    HortResearch, Mt Albert Research Centre, Private Bag 92169, Auckland, New Zealand
    Plant J 49:414-27. 2007
    ..accumulation in both heterologous and homologous systems, generating pigmented patches in transient assays in tobacco leaves and highly pigmented apple plants following stable transformation with constitutively expressed MdMYB10...
  7. ncbi Virus-induced gene silencing in tomato
    Yule Liu
    Department of Molecular, Cellular and Developmental Biology, OML 451, Yale University, PO Box 208104, New Haven, CT 06520 8104, USA
    Plant J 31:777-86. 2002
    We have previously demonstrated that a tobacco rattle virus (TRV)-based vector can be used in virus-induced gene silencing (VIGS) to study gene function in Nicotiana benthamiana...
  8. doi Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
    Giorgio Romagna
    Abich srl, biological and chemical toxicology research laboratory, Verbania VB, Italy
    Inhal Toxicol 25:354-61. 2013
    ..Electronic cigarettes (ECs) are used as alternatives to smoking; however, data on their cytotoxic potential are scarce...
  9. ncbi Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation
    Cyril Zipfel
    Botanical Institute, Zurich Basel Plant Science Centre, University of Basel, Hebelstrasse 1, CH 4056 Basel, Switzerland
    Cell 125:749-60. 2006
    ..These results demonstrate that EFR is the EF-Tu receptor and that plant defense responses induced by PAMPs such as EF-Tu reduce transformation by Agrobacterium...
  10. ncbi Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation
    Michael Walter
    Institut fur Botanik und Botanischer Garten, Molekulare Entwicklungsbiologie der Pflanzen, Universitat Munster, Schlossplatz 4, 48149 Munster, Germany
    Plant J 40:428-38. 2004
    ..the zinc finger protein lesion simulating disease 1 (LSD1) from Arabidopsis as well as the dimer formation of the tobacco 14-3-3 protein T14-3c...
  11. pmc Root-specific reduction of cytokinin causes enhanced root growth, drought tolerance, and leaf mineral enrichment in Arabidopsis and tobacco
    Tomáš Werner
    Institute of Biology Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universitat Berlin, D 14195 Berlin, Germany
    Plant Cell 22:3905-20. 2010
    ..We generated transgenic Arabidopsis thaliana and tobacco (Nicotiana tabacum) plants with enhanced root-specific degradation of the hormone cytokinin, a negative regulator ..
  12. ncbi A bacterial virulence protein suppresses host innate immunity to cause plant disease
    Kinya Nomura
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Science 313:220-3. 2006
    ..HopM1 mediates the destruction of AtMIN7 via the host proteasome. Our results illustrate a strategy by which a bacterial pathogen exploits the host proteasome to subvert host immunity and causes infection in plants...
  13. pmc EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study
    Pasquale Caponnetto
    Centro per la prevenzione e cura del tabagismo, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    PLoS ONE 8:e66317. 2013
    ..Users report buying them to help quit smoking, to reduce cigarette consumption, to relieve tobacco withdrawal symptoms, and to continue having a 'smoking' experience, but with reduced health risks...
  14. pmc The TGB1 movement protein of Potato virus X reorganizes actin and endomembranes into the X-body, a viral replication factory
    Jens Tilsner
    Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Plant Physiol 158:1359-70. 2012
    ..Our results indicate that the actin/endomembrane-reorganizing properties of TGB1 function to compartmentalize the viral gene products of PVX infection...
  15. ncbi Caterpillar-induced nocturnal plant volatiles repel conspecific females
    C M De Moraes
    USDA-ARS, CMAVE, PO Box 14565, Gainesville, Florida 32604, USA
    Nature 410:577-80. 2001
    ..Here we present chemical and behavioural assays showing that tobacco plants (Nicotiana tabacum) release herbivore-induced volatiles during both night and day...
  16. doi Recombinant protein production in a variety of Nicotiana hosts: a comparative analysis
    Andrew J Conley
    Department of Biology, University of Western Ontario, London, ON, Canada
    Plant Biotechnol J 9:434-44. 2011
    ..have been used to produce a wide range of vaccines, antibodies, biopharmaceuticals and industrial enzymes, tobacco has the most established history for the production of recombinant proteins...
  17. pmc Jasmonate and ppHsystemin regulate key Malonylation steps in the biosynthesis of 17-Hydroxygeranyllinalool Diterpene Glycosides, an abundant and effective direct defense against herbivores in Nicotiana attenuata
    Sven Heiling
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany 07745
    Plant Cell 22:273-92. 2010
    ..HGL-DTGs) that occur in concentrations equivalent to starch (mg/g fresh mass) in aboveground tissues of coyote tobacco (Nicotiana attenuata) and differ in their sugar moieties and malonyl sugar esters (0-2)...
  18. doi Stable internal reference genes for normalization of real-time RT-PCR in tobacco (Nicotiana tabacum) during development and abiotic stress
    Gregor W Schmidt
    Discipline of Genetics, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
    Mol Genet Genomics 283:233-41. 2010
    ..b>Tobacco (Nicotiana tabacum) is an important model in studies of plant gene expression, but stable reference genes have ..
  19. doi Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure
    Richard Strasser
    Institute of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    Plant Biotechnol J 6:392-402. 2008
    ..beta1,2-xylosyltransferase (XylT) and alpha1,3-fucosyltransferase (FucT) genes in Nicotiana benthamiana, a tobacco-related plant species widely used for recombinant protein expression...
  20. pmc Metformin prevents tobacco carcinogen--induced lung tumorigenesis
    Regan M Memmott
    National Cancer Institute Navy Medical Oncology, Room 5101, Building 8, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Cancer Prev Res (Phila) 3:1066-76. 2010
    Activation of the mammalian target of rapamycin (mTOR) pathway is an important and early event in tobacco carcinogen-induced lung tumorigenesis, and therapies that target mTOR could be effective in the prevention or treatment of lung ..
  21. doi A draft genome sequence of Nicotiana benthamiana to enhance molecular plant-microbe biology research
    Aureliano Bombarely
    Boyce Thompson Institute for Plant Research, Ithaca, NY, USA
    Mol Plant Microbe Interact 25:1523-30. 2012
    ..The sequence will also be useful for comparative genomics in the Solanaceae family as shown here by the discovery of microsynteny between N. benthamiana and tomato in the region encompassing the Pto and Prf genes...
  22. pmc Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
    Wenzhi Jiang
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA, Deparment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA and Department of Agronomy and Horticulture, University of Nebraska, Lincoln, NE 68588, USA
    Nucleic Acids Res 41:e188. 2013
    ..systems leading to successful expression of the Cas9/sgRNA system in two dicot plant species, Arabidopsis and tobacco, and two monocot crop species, rice and sorghum...
  23. pmc 22-Nucleotide RNAs trigger secondary siRNA biogenesis in plants
    Ho Ming Chen
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 107:15269-74. 2010
    ..Our data demonstrate that the function of small RNAs is influenced by size, and that a length of 22 nt facilitates the triggering of secondary siRNA production...
  24. ncbi Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    R D Hautamaki
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Science 277:2002-4. 1997
    ..Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke...
  25. doi Methods to study PAMP-triggered immunity using tomato and Nicotiana benthamiana
    Hanh P Nguyen
    Boyce Thompson Institute for Plant Research, Ithaca, NY, USA
    Mol Plant Microbe Interact 23:991-9. 2010
    ..These methods will facilitate limited genetic screens and detailed characterization of potential PTI-related genes in model and economically important Solanaceae spp.-pathogen interactions...
  26. doi Analysis of potato virus X replicase and TGBp3 subcellular locations
    Devinka Bamunusinghe
    Department of Entomology and Plant Pathology, Noble Research Center, Oklahoma State University, Stillwater, OK 74078, USA
    Virology 393:272-85. 2009
    ..Cerulenin, a drug that inhibits de novo membrane synthesis, also inhibited PVX replication. These combined data indicate that PVX replication relies on ER-derived membrane recruitment and membrane proliferation...
  27. pmc Phosphorylation of the Nicotiana benthamiana WRKY8 transcription factor by MAPK functions in the defense response
    Nobuaki Ishihama
    Laboratory of Defense in Plant Pathogen Interactions, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi 464 8601, Japan
    Plant Cell 23:1153-70. 2011
    ..Thus, MAPK-mediated phosphorylation of WRKY8 has an important role in the defense response through activation of downstream genes...
  28. doi Cellular pathways for viral transport through plasmodesmata
    Annette Niehl
    Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg, 12 rue du Général Zimmer, 67084, Strasbourg, France
    Protoplasma 248:75-99. 2011
    ..These mechanisms are supported by viral movement proteins and by other virus-encoded factors that interact among themselves and with plant cellular components to facilitate virus movement in a coordinated and regulated fashion...
  29. doi Herbivore-associated elicitors: FAC signaling and metabolism
    Gustavo Bonaventure
    Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knoell Str 8, D 07745 Jena, Germany
    Trends Plant Sci 16:294-9. 2011
    ..The interaction between Nicotiana attenuata and the specialist lepidopteran Manduca sexta presents a relevant biological system to understand HAE perception and signal transduction systems in plants...
  30. doi Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice
    Julia Pinkhasov
    The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ, USA
    Plant Biotechnol J 9:991-1001. 2011
    ..The results indicate that a plant-derived human tumour-associated antigen is equivalent to the human antigen in the context of immune recognition...
  31. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
    ..As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature...
  32. pmc Differential auxin-transporting activities of PIN-FORMED proteins in Arabidopsis root hair cells
    Anindya Ganguly
    Department of Biological Sciences and Genomics and Breeding Institute, Seoul National University, Seoul 151 742, Korea
    Plant Physiol 153:1046-61. 2010
    ..The auxin efflux activity of PIN8, which had not been previously demonstrated, was further confirmed using a tobacco (Nicotiana tabacum) cell assay system...
  33. doi Tobacco leaves and roots differ in the expression of proline metabolism-related genes in the course of drought stress and subsequent recovery
    Jana Dobra
    Institute of Experimental Botany, v v i, Academy of Sciences of the Czech Republic, Rozvojova 263, 165 02 Prague 6, Lysolaje, Czech Republic
    J Plant Physiol 168:1588-97. 2011
    ..The lack of activation of tobacco PDH genes and incomplete reduction of the P5CS A gene in leaves within 24-h of rehydration may reflect the need ..
  34. pmc Nonessential plastid-encoded ribosomal proteins in tobacco: a developmental role for plastid translation and implications for reductive genome evolution
    Tobias T Fleischmann
    Max Planck Institut fur Molekulare Pflanzenphysiologie, D 14476 Potsdam Golm, Germany
    Plant Cell 23:3137-55. 2011
    ..Although plastid translational activity is essential for cell survival in tobacco (Nicotiana tabacum), individual plastid ribosomal proteins can be nonessential...
  35. doi A review and assessment of menthol employed as a cigarette flavoring ingredient
    J Daniel Heck
    Scientific Affairs, AW Spears Research Center, Lorillard Tobacco Company, PO Box 21688, Greensboro, NC 27420 1688, USA
    Food Chem Toxicol 48:S1-38. 2010
    ..critically reviewed and a broad convergence of findings supports a judgment that menthol employed as a cigarette tobacco flavoring ingredient does not meaningfully affect the inherent toxicity of cigarette smoke or the human risks ..
  36. pmc R2R3-NaMYB8 regulates the accumulation of phenylpropanoid-polyamine conjugates, which are essential for local and systemic defense against insect herbivores in Nicotiana attenuata
    Harleen Kaur
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, D 07745 Jena, Germany
    Plant Physiol 152:1731-47. 2010
    ..attenuata are consistent with the predictions of the optimal defense theory: plants preferentially protect their most fitness-enhancing and vulnerable parts, young tissues and reproductive organs, to maximize their fitness...
  37. doi Insects betray themselves in nature to predators by rapid isomerization of green leaf volatiles
    Silke Allmann
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knöll Str 8, DE 07745 Jena, Germany
    Science 329:1075-8. 2010
    ..Hence, attacking herbivores initiate the release of an indirect defense a full day before the attacked plants manufacture their own defensive compounds...
  38. ncbi Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol
    Ying Bo Mao
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, P R China
    Nat Biotechnol 25:1307-13. 2007
    ....
  39. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  40. ncbi Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Science 299:396-9. 2003
    ..Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs.
  41. pmc Overexpression of the soybean GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought, and diseases in transgenic tobacco
    Gaiyun Zhang
    The National Key Facility for Crop Genetic Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China
    J Exp Bot 60:3781-96. 2009
    ..Ectopic expression of the GmERF3 gene in transgenic tobacco plants induced the expression of some PR genes and enhanced resistance against infection by Ralstonia ..
  42. ncbi Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
    Gerd P Pfeifer
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California, CA 91010, USA
    Oncogene 21:7435-51. 2002
    ..p53 mutations are frequent in tobacco-related cancers and the mutation load is often higher in cancers from smokers than from nonsmokers...
  43. pmc Modulation of transcriptome and metabolome of tobacco by Arabidopsis transcription factor, AtMYB12, leads to insect resistance
    Prashant Misra
    National Botanical Research Institute, Council of Scientific and Industrial Research, Rana Pratap Marg, Lucknow 226 001, India
    Plant Physiol 152:2258-68. 2010
    ..We have expressed an Arabidopsis (Arabidopsis thaliana) transcription factor, AtMYB12, in tobacco (Nicotiana tabacum), which resulted in enhanced expression of genes involved in the phenylpropanoid pathway, ..
  44. doi Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    F Liu
    Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncogene 29:3650-64. 2010
    Limited information is available regarding epigenomic events mediating initiation and progression of tobacco-induced lung cancers...
  45. pmc An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles
    Luca Santi
    The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ 85287 5401, USA
    Vaccine 26:1846-54. 2008
    ..We now overcome these constraints with an efficient tobacco mosaic virus (TMV)-derived transient expression system using leaves of Nicotiana benthamiana...
  46. doi Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometry
    Hyun Ji Kim
    Department of Environmental Science, Kongju National University, Kongju 314 701, South Korea
    J Chromatogr A 1291:48-55. 2013
    A liquid chromatography-tandem mass spectrometric method was described to detect tobacco-specific nitrosamines (TSNAs) in replacement liquids of electronic cigarettes...
  47. pmc A novel cis-acting element in an Arabidopsis gene is involved in responsiveness to drought, low-temperature, or high-salt stress
    K Yamaguchi-Shinozaki
    Laboratory of Plant Molecular Biology, Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Plant Cell 6:251-64. 1994
    ..We analyzed the rd29A promoter in both transgenic Arabidopsis and tobacco and identified a novel cis-acting, dehydration-responsive element (DRE) containing 9 bp, TACCGACAT, that is ..
  48. pmc Lung carcinogenesis by tobacco smoke
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 131:2724-32. 2012
    ..37 million deaths per year...
  49. pmc British American Tobacco on Facebook: undermining Article 13 of the global World Health Organization Framework Convention on Tobacco Control
    Becky Freeman
    A27 School of Public Health, Room 129A, University of Sydney, Sydney, NSW 2006, Australia
    Tob Control 19:e1-9. 2010
    The World Health Organization Framework Convention on Tobacco Control (WHO FCTC) bans all forms of tobacco advertising, promotion and sponsorship...
  50. ncbi Induction and suppression of RNA silencing by an animal virus
    Hongwei Li
    Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA
    Science 296:1319-21. 2002
    ..These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms...
  51. pmc Silencing of aphid genes by dsRNA feeding from plants
    Marco Pitino
    Department of Disease and Stress Biology, The John Innes Centre, Norwich Research Park, Norwich, United Kingdom
    PLoS ONE 6:e25709. 2011
    ....
  52. pmc Identification of wounding and topping responsive small RNAs in tobacco (Nicotiana tabacum)
    She Tang
    Department of Agronomy and James D, Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China
    BMC Plant Biol 12:28. 2012
    ..Over 4,000 miRNAs and several classes of siRNAs have been identified in plants, but in tobacco only computational prediction has been performed and no tobacco-specific miRNA has been experimentally identified...
  53. ncbi A comparative study of the mutagenicity of various types of tobacco products
    W S Rickert
    Labstat International ULC, 262 Manitou Drive, Kitchener, Ont, Canada N2C 1L3
    Regul Toxicol Pharmacol 48:320-30. 2007
    Toxicological data are an important aspect of tobacco product characterization...
  54. pmc Pseudomonas syringae hijacks plant stress chaperone machinery for virulence
    Joanna Jelenska
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:13177-82. 2010
    ..Enhanced susceptibility of Hsp70-depleted plants to nonpathogenic strains of P. syringae supports a defense-promoting role for Hsp70...
  55. pmc Engineering mammalian mucin-type O-glycosylation in plants
    Zhang Yang
    Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Flakkebjerg, 4200 Slagelse, Denmark
    J Biol Chem 287:11911-23. 2012
    ..The observed hydroxyproline modifications, however, call for additional future engineering efforts...
  56. doi Expression of a wheat MYB gene in transgenic tobacco enhances resistance to Ralstonia solanacearum, and to drought and salt stresses
    Hongxia Liu
    The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China
    Funct Integr Genomics 11:431-43. 2011
    ..The TaPIMP1 gene was transferred into tobacco (Nicotiana tabacum L.) cultivar W38 by Agrobacterium-mediated transformation...
  57. pmc A high density genetic map of tobacco (Nicotiana tabacum L.) obtained from large scale microsatellite marker development
    Gregor Bindler
    Applied Research Department, Philip Morris International, Quai Jeanrenaud 5, 2000, Neuchatel, Switzerland
    Theor Appl Genet 123:219-30. 2011
    b>Tobacco (Nicotiana tabacum L.) is a species in the large family of the Solanaceae and is important as an agronomic crop and as a model system in plant biotechnology...
  58. ncbi The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder
    D Hoffmann
    American Health Foundation, Valhalla, New York 10595, USA
    Chem Res Toxicol 14:767-90. 2001
    ..Laboratory assays with tobacco tar on mouse skin and smoke inhalation experiments with hamsters provided further evidence for this relationship...
  59. pmc Engineered polyamine catabolism preinduces tolerance of tobacco to bacteria and oomycetes
    Panagiotis N Moschou
    Department of Biology, University of Crete, Crete, 71409 Heraklion, Greece
    Plant Physiol 149:1970-81. 2009
    ..In wild-type tobacco (Nicotiana tabacum 'Xanthi') plants, infection by the compatible pathogen Pseudomonas syringae pv tabaci resulted ..
  60. pmc Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis
    Clemencia M Rojas
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73402, USA
    Plant Cell 24:336-52. 2012
    ..Here we show that GOX is an alternative source for the production of H(2)O(2) during both gene-for-gene and nonhost resistance responses...
  61. pmc MYB8 controls inducible phenolamide levels by activating three novel hydroxycinnamoyl-coenzyme A:polyamine transferases in Nicotiana attenuata
    Nawaporn Onkokesung
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany 07745
    Plant Physiol 158:389-407. 2012
    ..In the native tobacco (Nicotiana attenuata), the accumulation of two major PAs, caffeoylputrescine and dicaffeoylspermidine (DCS), ..
  62. pmc Quantitative proteomics reveals a dynamic association of proteins to detergent-resistant membranes upon elicitor signaling in tobacco
    Thomas Stanislas
    Institut National de Recherche Agronomique, Unité Mixte de Recherche Plante Microbe Environnement 1088 CNRS 5184 Université de Bourgogne, 17 rue Sully, BP 86510 F 21000 Dijon, France
    Mol Cell Proteomics 8:2186-98. 2009
    ..used (14)N/(15)N metabolic labeling to compare, using a global quantitative proteomics approach, the content of tobacco detergent-resistant membranes extracted from cells treated or not with cryptogein, an elicitor of defense ..
  63. doi Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells
    Adam Csordas
    Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cardiovasc Res 92:141-8. 2011
    ....
  64. pmc Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen
    Maryam Rafiqi
    Division of Plant Science, Research School of Biology, College of Medicine, Biology, and Environment, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    Plant Cell 22:2017-32. 2010
    ..Transient expression of secreted AvrL567 and AvrM proteins fused to cerulean fluorescent protein in tobacco (Nicotiana tabacum) and flax cells resulted in intracellular accumulation of the fusion proteins...
  65. pmc Cigarettes butts and the case for an environmental policy on hazardous cigarette waste
    Thomas E Novotny
    Center for Tobacco Control Research and Education University of California San Francisco, San Francisco, CA 94143, USA
    Int J Environ Res Public Health 6:1691-705. 2009
    ..Additional research is needed on the various policy options, including behavioral research on the impact of banning the sale of filtered cigarettes altogether...
  66. ncbi Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants
    Sylvestre Marillonnet
    Icon Genetics, Biozentrum Halle, Weinbergweg 22, D 06120 Halle Saale, Germany
    Nat Biotechnol 23:718-23. 2005
    ..tumefaciens, the high expression yield obtained with viral vectors, and the post-translational capabilities of a plant), does not require genetic modification of plants and is faster than other existing methods...
  67. pmc Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis
    Laurent Hoffmann
    Institut de Biologie Moleculaire des Plantes, Unite Propre de Recherche, 2357 du Centre National de la Recherche Scientifique, Universite Louis Pasteur, 67000 Strasbourg, France
    Plant Cell 16:1446-65. 2004
    ..Specific antibodies raised against the recombinant tobacco (Nicotiana tabacum) acyltransferase revealed the accumulation of the enzyme in stem vascular tissues of tobacco, ..
  68. pmc PIP1 plasma membrane aquaporins in tobacco: from cellular effects to function in plants
    Franka Siefritz
    Department of Plant Physiology and Biophysics, University of Wurzburg, D 97082 Wurzburg, Germany
    Plant Cell 14:869-76. 2002
    ..The tobacco plasma membrane aquaporin NtAQP1 was used to elucidate this issue...
  69. doi Begomovirus-whitefly mutualism is achieved through repression of plant defences by a virus pathogenicity factor
    Tong Zhang
    State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, China
    Mol Ecol 21:1294-304. 2012
    ..As the test plant is an important economic crop, the results also have substantial implications for developing novel strategies for management of crop viruses and the insect vectors associated with them...
  70. ncbi Expression of a Phytophthora sojae necrosis-inducing protein occurs during transition from biotrophy to necrotrophy
    Dinah Qutob
    Agriculture and Agri Food Canada, 1391 Sandford Street, London, Ontario, Canada N5V 4T3
    Plant J 32:361-73. 2002
    ..This study suggests that the P. sojae necrosis-inducing protein facilitates the colonization of host tissues during the necrotrophic phase of growth...
  71. pmc Cytokinins mediate resistance against Pseudomonas syringae in tobacco through increased antimicrobial phytoalexin synthesis independent of salicylic acid signaling
    Dominik K Grosskinsky
    Institute for Plant Sciences, Department of Plant Physiology, University of Graz, 8010 Graz, Austria
    Plant Physiol 157:815-30. 2011
    ..level of bactericidal activities and up-regulated synthesis of the two major antimicrobial phytoalexins in tobacco (Nicotiana tabacum), scopoletin and capsidiol...
  72. pmc MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays
    Sorina C Popescu
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 23:80-92. 2009
    ..Our predicted MKK-MPK phosphorylation network constitutes a valuable resource to understand the function and specificity of MPK signaling systems...
  73. pmc Pectin methylesterase, a regulator of pollen tube growth
    Maurice Bosch
    Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Plant Physiol 138:1334-46. 2005
    ....
  74. doi Nicotiana benthamiana: its history and future as a model for plant-pathogen interactions
    Michael M Goodin
    Department of Plant Pathology, University of Kentucky, Lexington 40546, USA
    Mol Plant Microbe Interact 21:1015-26. 2008
    ..Finally, we propose that N. benthamiana is well situated to become a premier plant cell biology model, particularly for the virology community, who as a group were the first to recognize the potential of this unique Australian native...
  75. pmc The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis
    Lionel Navarro
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, United Kingdom
    Plant Physiol 135:1113-28. 2004
    ..Twenty-one tobacco Avr9/Cf-9 rapidly elicited (ACRE) cDNA full-length sequences were used to search for their Arabidopsis orthologs (..
  76. pmc A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs
    Dániel Silhavy
    Agricultural Biotechnology Center, Plant Biology Institute, PO Box 411, H 2101, Godollo, Hungary
    EMBO J 21:3070-80. 2002
    ..Moreover, the observation that p19-expressing transgenic plants show altered leaf morphology might indicate that the p19-targeted PTGS pathway is also important in the regulation of plant development...
  77. ncbi Enhancers and core promoter elements are essential for the activity of a cryptic gene activation sequence from tobacco, tCUP
    K Wu
    Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario
    Mol Genet Genomics 265:763-70. 2001
    ..We have recently isolated such a cryptic sequence from tobacco, tCUP, that can act as a promoter...
  78. pmc In planta protein sialylation through overexpression of the respective mammalian pathway
    Alexandra Castilho
    Department of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    J Biol Chem 285:15923-30. 2010
    ..Besides the biotechnological impact of the achievement, this work may serve as a general model for the manipulation of complex traits into plants...
  79. doi Identification and characterization of microRNAs and their target genes in tobacco (Nicotiana tabacum)
    Taylor P Frazier
    Department of Biology, East Carolina University, Greenville, NC 27858, USA
    Planta 232:1289-308. 2010
    ..Since a list of miRNAs has never been generated for tobacco, we employed genome survey sequence analysis to computationally identify 259 potentially conserved tobacco miRNAs,..
  80. pmc Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease
    Jules Ade
    Department of Biology, Indiana University, Bloomington, IN 47405 7107, USA
    Proc Natl Acad Sci U S A 104:2531-6. 2007
    ..Combined, these data suggest that ATP versus ADP binding functions as a molecular switch that is flipped by cleavage of PBS1...
  81. pmc Chloroplast-derived enzyme cocktails hydrolyse lignocellulosic biomass and release fermentable sugars
    Dheeraj Verma
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816 2364, USA
    Plant Biotechnol J 8:332-50. 2010
    ..xylan esterase, beta glucosidase and lipase genes from bacteria or fungi were expressed in Escherichia coli or tobacco chloroplasts. A PCR-based method was used to clone genes without introns from Trichoderma reesei genomic DNA...
  82. pmc The ups and downs of genome size evolution in polyploid species of Nicotiana (Solanaceae)
    I J Leitch
    Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK
    Ann Bot 101:805-14. 2008
    ..Recent advances in understanding phylogenetic relationships of Nicotiana species and dating polyploid formation enable a temporal dimension to be added to the analysis of genome size evolution in these polyploids...
  83. ncbi Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke
    K Rustemeier
    INBIFO Institut für biologische Forschung, Fuggerstr 3, D 51149, Koln, Germany
    Food Chem Toxicol 40:93-104. 2002
    ..caused by the higher transfer rates of the added ingredients to the smoke compared to the transfer from the tobacco part of the filler...
  84. pmc Tobacco smoking and oral clefts: a meta-analysis
    Julian Little
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland
    Bull World Health Organ 82:213-8. 2004
    ..To examine the association between maternal smoking and non-syndromic orofacial clefts in infants...
  85. pmc A small-cell lung cancer genome with complex signatures of tobacco exposure
    Erin D Pleasance
    Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 463:184-90. 2010
    Cancer is driven by mutation. Worldwide, tobacco smoking is the principal lifestyle exposure that causes cancer, exerting carcinogenicity through >60 chemicals that bind and mutate DNA...
  86. ncbi Rapid, transient expression of fluorescent fusion proteins in tobacco plants and generation of stably transformed plants
    Imogen A Sparkes
    School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK
    Nat Protoc 1:2019-25. 2006
    ..Transient transformation of tobacco leaf epidermal cells is a relatively fast technique to assess expression of genes of interest...
  87. pmc Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
    Athanasios Valavanidis
    Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15784 Athens, Greece
    Int J Environ Res Public Health 6:445-62. 2009
    b>Tobacco smoke contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals and reactive oxygen species (ROS) in the particulate and the gas phase with the potential for biological oxidative ..
  88. pmc Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire
    Qunqing Wang
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Plant Cell 23:2064-86. 2011
    ..In support of this hypothesis, misexpression of key immediate-early and early effectors severely reduced the virulence of P. sojae transformants...
  89. pmc Class VIII myosins are required for plasmodesmatal localization of a closterovirus Hsp70 homolog
    Dror Avisar
    Department of Botany and Plant Pathology, Oregon State University, Cordley Hall 2082, Corvallis, OR 97331, USA
    J Virol 82:2836-43. 2008
    ..Interestingly, plasmodesmatal localization of the Tobacco mosaic virus movement protein and Arabidopsis protein RGP2 was not affected by myosin VIII tail overexpression...
  90. doi Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic
    Melanie Oey
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    Plant J 57:436-45. 2009
    ....
  91. doi Superwobbling facilitates translation with reduced tRNA sets
    Marcelo Rogalski
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    Nat Struct Mol Biol 15:192-8. 2008
    ..We also show that the price for superwobbling is a reduced translational efficiency, which explains why most organisms prefer pairs of isoaccepting tRNAs over the superwobbling mechanism...
  92. doi Tobacco, a highly efficient green bioreactor for production of therapeutic proteins
    Reynald Tremblay
    Department of Biology, University of Western Ontario, London, Ontario, Canada N6A 5B7
    Biotechnol Adv 28:214-21. 2010
    ..b>Tobacco has been and will continue to be a major crop for molecular farming and offers several practical advantages over ..
  93. pmc Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    Kip A West
    Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA
    J Clin Invest 111:81-90. 2003
    b>Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 deaths per year occurring in the US...
  94. ncbi The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants
    Y Sugiyama
    Center for Gene Research, Nagoya University, Chikusa ku, 464 0812 Nagoya, Japan
    Mol Genet Genomics 272:603-15. 2005
    b>Tobacco is a valuable model system for investigating the origin of mitochondrial DNA (mtDNA) in amphidiploid plants and studying the genetic interaction between mitochondria and chloroplasts in the various functions of the plant cell...
  95. ncbi Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene
    Patrick Römer
    Institute of Biology, Department of Genetics, Martin Luther University Halle Wittenberg, D 06099 Halle Saale, Germany
    Science 318:645-8. 2007
    ..Our data suggest a recognition mechanism in which the Avr protein binds and activates the promoter of the cognate R gene...
  96. pmc Distribution of fitness and virulence effects caused by single-nucleotide substitutions in Tobacco Etch virus
    Purificación Carrasco
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, Avenida de los Naranjos s n, 46022 Valencia, Spain
    J Virol 81:12979-84. 2007
    ..Here we used site-directed mutagenesis to create a collection of 66 clones of Tobacco etch potyvirus, each carrying a different, randomly chosen, single-nucleotide substitution...
  97. doi Next generation sequencing reveals genome downsizing in allotetraploid Nicotiana tabacum, predominantly through the elimination of paternally derived repetitive DNAs
    Simon Renny-Byfield
    School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
    Mol Biol Evol 28:2843-54. 2011
    ..Thus, the three genomes of N. sylvestris, N. tomentosiformis, and N. tabacum have experienced different evolutionary trajectories, with genomes that are dynamic, stable, and downsized, respectively...
  98. doi Non-food/feed seeds as biofactories for the high-yield production of recombinant pharmaceuticals
    Francesca Morandini
    Department of Biotechnology, University of Verona, Verona, Italy
    Plant Biotechnol J 9:911-21. 2011
    ..A vector designed for direct subcloning by Gateway® recombination was developed and tested in Arabidopsis, tobacco and petunia plants for the production of a chimeric form (GAD67/65) of the 65 kDa isoform of glutamic acid ..
  99. pmc Beyond light and mild: cigarette brand descriptors and perceptions of risk in the International Tobacco Control (ITC) Four Country Survey
    Seema Mutti
    Department of Health Studies and Gerontology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada
    Addiction 106:1166-75. 2011
    ..To examine perceptions of risk related to type of cigarette brand...
  100. pmc Characterization of a grapevine R2R3-MYB transcription factor that regulates the phenylpropanoid pathway
    Laurent Deluc
    Unité Mixte de Recherche 619, Physiologie et Biotechnologie Végétales, Universite Bordeaux 1, Universite Bordeaux 2, Institut National de la Recherche Agonomique, Centre de Recherche de Bordeaux, 33883 Villenave d Ornon, France
    Plant Physiol 140:499-511. 2006
    ..Overexpression of VvMYB5a in tobacco (Nicotiana tabacum) affects the expression of structural genes controlling the synthesis of phenylpropanoid and ..
  101. pmc Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco
    Xiao San Huang
    Key Laboratory of Horticultural Plant Biology of the Ministry of Education, National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    J Exp Bot 62:5191-206. 2011
    ..Transgenic overexpression of PtrMAPK in tobacco confers dehydration and drought tolerance...

Research Grants77

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..AGEs from high blood sugar or from inhalation of AGES from tobacco products amplify inflammation by ligation of the cell-surface receptor for AGEs, or RAGE...
  2. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..We will also collect information on health history, clinical characteristics, tobacco smoke exposure, diet and time-activity patterns...
  3. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    7. Project Summary/Abstract Nicotine contained in tobacco is considered to be the primary reinforcing component responsible for tobacco addiction in human smokers[1]...
  4. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..number of environmental exposures that likely contribute to these inflammatory respiratory conditions, to include tobacco smoke and diesel exhaust. Nearly half of OEF/OIF Veterans started or re-started smoking during deployment...
  5. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
    ..by the government, and shall provide necessary scientific writing, technical and logistical support to the Tobacco Control Research Branch (TCRB) in the conduct of 1) writing, editorial and graphic services for scientific ..
  6. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..nature, the underserved socio-economic nature of the patient population, and the constant advertising by tobacco companies, smoking during pregnancy will continue to adversely victimize millions of babies worldwide...
  7. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite improvements in tobacco control, the prevalence of cigarette smoking remains high at 27% among Veterans and 21% among the general U.S. population (~46 million U.S. adults)...
  8. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..we yet know little about how the immune response is initiated and organized against a toxic inhalant such as tobacco smoke...
  9. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..cancer diagnosis;breast, cervical, colorectal, liver, and lung cancer;liver cirrhosis;cardiovascular diseases;tobacco-related diseases;and other diseases caused by exposure to carcinogens, endocrine disruptors and respiratory ..
  10. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..Endotoxin is almost universally present, and has been found at high levels in tobacco smoke, homes burning biomass fuel, in the context of various occupations especially cotton textile work, and more ..
  11. Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)
    PATRICK O'CONNOR; Fiscal Year: 2013
    ..diverse faculty of independent researchers in illicit and prescription drug abuse and addiction, tobacco, alcohol, HIV, and medical complexities such as pain and hepatitis C;(2) Synergy with well established, high ..
  12. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    Project Summary/Abstract Tobacco and alcohol use and genetic susceptibility are major risk factors for squamous cell carcinoma of the head and neck (SCCHN)...
  13. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    b>Tobacco related lung diseases, including chronic obstructive pulmonary disease (COPD) with and without emphysema, are among the major causes of lung-related disability and death worldwide...
  14. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..Previous studies have shown (1) that the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) is a major lung carcinogen in tobacco ..
  15. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..nature, the underserved socio-economic nature of the patient population, and the constant advertising by tobacco companies, smoking during pregnancy will continue to adversely victimize millions of babies worldwide...
  16. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..include: Factors Contributing to Disparities in Diabetic Kidney Disease Reaching Populations in Need: Treating Tobacco Dependence among Diverse Smokers in the Inpatient Psychiatry Setting Culture, Smoking, Readiness to Quit, and ..
  17. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..half the worldwide population, are exposed to smoke from biomass fuel compared with 1 billion people who smoke tobacco, which suggests that exposure to biomass smoke might be the biggest risk factor for respiratory diseases such as ..
  18. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..These include: 1) prenatal factors such as fetal exposure to alcohol and tobacco smoke, drugs of use and abuse and, in some cases, mode of delivery;2) intra-partum factors such as presence and ..
  19. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Children are involuntarily exposed to tobacco both in utero through maternal smoking and during childhood from secondhand smoke (SHS)...
  20. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..b>Tobacco and alcohol consumption are well established risk factors for HNSCC...
  21. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..Many tobacco-specific carcinogens present in cigarette smoke cause DNA damage, leading to the mutation of vital genes like Ras,..
  22. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..chronic infection with hepatitis B (HBV) and C viruses (HCV), while additional risk factors include exposure to tobacco smoke...
  23. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
    Exposure and biological response biomarkers of cigarette smoke. Exposure to tobacco smoke (mainstream and environmental) is a leading cause of death in the US...
  24. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..The major risk factors for esophageal SCC are tobacco and alcohol use, consumption of salty and moldy foods that are frequently contaminated with N-nitrosamine ..
  25. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..Recent studies have shown that tobacco smoking is associated with cancer of the ovary...
  26. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ..k.a. environmental tobacco smoke (ETS)...
  27. Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors
    JOHN CHRISTOPHER WEISS; Fiscal Year: 2010
    ..of patient-reported data to previous clinical documentation of ancillary factors such as QOL, substance abuse, tobacco use, mental health status;3...
  28. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..Current first-line medications for Tobacco Dependence include nicotine replacement therapies (such as the patch, gum, lozenge, nasal spray, and inhaler), ..
  29. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Tobacco use is now recognized as the single most responsible cause of avoidable death worldwide representing approximately 10% of all deaths globally...
  30. Molecular Analysis of Alcohol Effects on Human Oral Epithelium Cells'Epigenome
    Alison Urvalek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In addition to tobacco, alcohol is the major risk factor for head and neck cancer...
  31. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..D. Anderson Cancer Center in collaboration with the Baylor College of Medicine (R03 ES11481-01) and the Texas Tobacco Settlement Grant...
  32. PPAR gamma Agonists for Lung Cancer Chemoprevention
    Robert Keith; Fiscal Year: 2013
    ..Lung cancer is a medical priority for the Department of Veterans Affairs due to the high rates of tobacco addiction acquired by military personnel and recent data shows tobacco use rates higher than that of the general ..
  33. Factors for Epigenetic Silencing of Lung Cancer Genes
    Steven Belinsky; Fiscal Year: 2009
    ..in critical genes involved in the bioactivation, detoxification, and repair of DNA damage stemming from tobacco carcinogens and the subsequent acquisition of somatic genetic and epigenetic changes in critical regulatory genes...
  34. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: It is widely accepted that exposure to environmental tobacco smoke causes development and exacerbation of respiratory disorders, including asthma...
  35. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..RELEVANCE (See instructions);COPD is a morbid condition, primarily caused by tobacco smoking and is the fourth leading cause of death in the United States...
  36. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..COPD is usually caused by tobacco smoke that disrupts the epithelial barrier and induces a migration of different cell type such as neutrophils, ..
  37. Measuring Tobacco Mortality within the Million Death Study in India
    Prabhat Jha; Fiscal Year: 2010
    The project will measure the mortality consequences of tobacco smoking and chewing among 1.3 million households (about 7...
  38. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    ..day GT consumption does to epithelial cell function in humans who are at high risk to get aero-digestive cancers (tobacco smokers). This approach has the potential to show how GT may inhibit tumor formation...
  39. Induction of Nerve Growth Factor by Nicotine Leads to Airway Dysfunction
    CHERRY P WONGTRAKOOL; Fiscal Year: 2013
    ..b>Tobacco smoke exposure can promote airway hyperresponsiveness (AHR), a characteristic feature of asthma defined as airway ..
  40. Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis Model
    Lorraine J Gudas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Head and neck cancer is the sixth most common cancer worldwide. Tobacco and/or alcohol are involved in approximately 75% of all human squamous cell carcinomas of the head and neck (SCCHN)...
  41. Biomedical Computing Support of Cancer Control and Surveillance
    DAVID RONEY; Fiscal Year: 2009
    ..from basic behavioral research to research on the development and dissemination of interventions in areas such as tobacco use, dietary behavior, sun protection, decision making, and counseling about testing for cancer susceptibility ..
  42. A+ Head Start Intervention for Smoke Free Homes
    Cynthia S Rand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Environmental tobacco smoke (ETS) exposure has been identified as a significant threat to children's respiratory health and has been clearly linked to increased risk of asthma, bronchitis, ..
  43. Prenatal Cocaine Exposure: Young Adult Follow Up
    Ruth Rose-Jacobs; Fiscal Year: 2013
    ..composite measurement of overall level of intrauterine substance exposures (IUSE) including levels of cocaine, tobacco, alcohol, &marijuana in a single scale, as well as the individual substances as distinct variables...
  44. MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCH
    MARK WALTER FRAMPTON; Fiscal Year: 2013
    ..Major research themes include lung immunology, inflammation and infection;pulmonary fibrosis and remodeling;tobacco smoke and chronic obstructive pulmonary disease;and health effects of air pollution...
  45. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Nicotine is the major psychoactive component of tobacco smoke responsible for tobacco addiction...
  46. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..in less educated and impoverished communities, NICU families with household smokers are at significant risk for tobacco-related health disparities--a substantial burden to families with limited resources and the communities in which ..
  47. Predictors of Prenatal Care Providers Counseling Women on Tobacco Use/Exposure
    BETH LEONG PINELES; Fiscal Year: 2013
    ..Approximately 40% of pregnant women are exposed to tobacco smoke during pregnancy through either active or passive smoking...
  48. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..Major risk factors for HNSCC include tobacco and alcohol use...
  49. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..Deployed military personnel are at increased risk due to prolonged air and ground transport, dehydration, tobacco use, and extended immobility during hospitalizations for severe injuries...
  50. Mdig gene and histone demethylation in lung cancer
    Fei Chen; Fiscal Year: 2013
    ..The main cause of lung cancer is the environmental and occupational exposure to carcinogens, including tobacco smoking and occupational dust...
  51. 2-Amino-9H-pyrido[2,3-b]indole: a potential colorectal carcinogen formed in tobac
    Robert J Turesky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epidemiologic studies have shown that tobacco smoking is a risk factor for colorectal cancer, but the chemicals associated with this risk are unknown...
  52. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..proteasomal anti-apoptotic cytoprotective responses, improves bacterial phagocytosis and killing, and reverses tobacco-smoke induced corticosteroid resistance...
  53. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..e., poor diet, low physical activity, tobacco use) risk factors associated with cardiovascular disease...
  54. Oral immune modulatory therapy using antigens bioencapsulated in plant cells
    Roland W Herzog; Fiscal Year: 2013
    ..Recently, we demonstrated that oral delivery of F.IX, produced by tobacco chloroplasts and bioencapsulated in plant cells, prevents formation of inhibitors and anaphylaxis in protein ..
  55. Adolescent brains, nicotine and endogenous prototoxins
    Rae Nishi; Fiscal Year: 2010
    ..b>Tobacco dependence is viewed as a "pediatric disease" because most people begin smoking during adolescence...
  56. Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young Ad
    FROUGH SAADATMAND; Fiscal Year: 2013
    ..and community violence on depression (symptoms of depression and clinical depression), ATOD use (alcohol, tobacco and other drug), HIV risk behaviors (condom use, number of sexual partners), and immune system function (..
  57. Effect of Baclofen on Alcohol Cue-Elicited Urges to Drink and Smoke
    GEORGE ANTHONY KENNA; Fiscal Year: 2011
    ..Alcohol-dependent smokers show an increased risk of tobacco-related mortality and morbidity, and smoking-related illnesses are the leading cause of death among alcoholics...
  58. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..One of the highest risk factors for SIDS is cigarette smoking and while tobacco smoke contains a number of deleterious agents in addition to nicotine, nicotine is of particular concern in ..
  59. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2013
    ..The variation in the susceptibility to lung cancer among smokers not only depends on their exposure to tobacco carcinogens, but also upon genetic, dietary, and other environmental factors. Tobacco- specific nitrosamines (i.e...
  60. Chemoprevention by black raspberry in oral cancer induced by DB[a,l]P in mice
    KARAM E EL-BAYOUMY; Fiscal Year: 2013
    ..b>Tobacco smoking is considered a major etiological factor in the development of oral cancer...
  61. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..arylamines, specifically, 4-aminobiphenyl (4-ABP), beta-naphthylamine, and benzidine, are also contained in tobacco smoke, and are the most likely causative agents responsible for the raised rates of bladder cancer in smokers...
  62. Mechanisms of Virus Replication and Gene Expression
    ANNE ELIZABETH SIMON; Fiscal Year: 2013
    ..West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus...
  63. Brief Dental Office Intervention with Tobacco Quitline
    Jon Ebbert; Fiscal Year: 2005
    ..Dental hygiene visits provide an opportunity to acquire information about the impact of tobacco use on oral health...
  64. Tobacco Cessation via Doctors of Chiropractic
    Judith Gordon; Fiscal Year: 2007
    ..doctors, nurses, dentists, and dental hygienists have been shown to be effective in helping their patients quit tobacco. However, Doctors of Chiropractic (DCs) have not been utilized in this role! DCs can provide a unique channel for ..
  65. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    The most important factor for cancer development in the United States is exposure to tobacco products. The most prevalent route of exposure to tobacco is cigarette smoking with increasing use of smokeless tobacco products in recent years...
  66. Tobacco Quitlines: An Adjunct to Dental Interventions
    Judith Gordon; Fiscal Year: 2006
    ..brief dental office-based interventions designed to help patients quit either cigarette smoking or smokeless tobacco use, and to compare these two dental office-based interventions with usual care...
  67. ASK, ADVISE, REFER: Promoting Pharmacy-based Referrals to Tobacco Quitlines
    Karen S Hudmon; Fiscal Year: 2010
    ..the health-care system and the general public, have the potential to substantially reduce the prevalence of tobacco use-particularly among key population groups for which tobacco use is a major risk factor for development or ..
  68. The Impact of Smoke-Free Policy on Quitline Utilization and Smoking Outcomes
    ANITA FAY FERNANDER; Fiscal Year: 2010
    ..S. One of the Healthy People 2010 objectives is to reduce tobacco use among adults to 12% or less...
  69. TOBACCO USE PREVENTION AND CESSATION FOR EMPLOYED YOUTH
    Glorian Sorensen; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Description) Tobacco control among adolescents is on the increase...
  70. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert C Klesges; Fiscal Year: 2012
    ..entitled "NIH Competitive Revision Applications for Research Relevant to the Family Smoking Prevention and Tobacco Control Act" (R01)...
  71. Analysis of tobacco industry documents--Asia/Australia
    Simon Chapman; Fiscal Year: 2004
    ..review and disseminate the strategic national, regional and international significance of the hitherto "secret" tobacco industry documents containing explicit material about tobacco control issues in six nations: Australia; New ..
  72. Web-Based Respiratory Education About Tobacco and Health
    Judith Gordon; Fiscal Year: 2009
    ..We propose to develop an interactive Internet-based program (WeBREATHe: Web-Based Respiratory Education About Tobacco and Health) to train pediatric respiratory therapists and nurses to provide brief, hospital-based tobacco ..
  73. Diseminating a Tobacco Curriculum for Pharmacy Schools
    Karen Hudmon; Fiscal Year: 2005
    Research shows that providing pharmacists with specialized tobacco cessation counseling training leads to significant increases in counseling activities...
  74. Translating Dental Student Tobacco Education to Practice
    KATHLEEN RANKIN; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Dentists are in a unique position to intervene with patients who use tobacco products...
  75. Incentive-Based Intervention for Smoking Cessation and Prevention in High Schools
    Suchitra Krishnan Sarin; Fiscal Year: 2010
    ..acceptability and preliminary efficacy of a novel incentive-based behavioral intervention to promote a tobacco-free lifestyle among high school adolescents...
  76. Establishment of the Syrian Center for Tobacco Studies
    Kenneth Ward; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Tobacco use is becoming epidemic in developing countries...
  77. WEB BASED SUPPORT--COMMUNITY TOBACCO CONTROL COALITIONS
    David Buller; Fiscal Year: 2003
    ..A collaborative project between the AMC Cancer Research Center, Colorado ASSIST Study, and the Coalition for Tobacco-Free Colorado is proposed...