nigella sativa

Summary

Summary: A plant genus of the family RANUNCULACEAE that contains alpha-hederin, a triterpene saponin in the seeds, and is the source of black seed oil.

Top Publications

  1. ncbi Pharmacological and toxicological properties of Nigella sativa
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 17:299-305. 2003
  2. ncbi Biochemical effects of Nigella sativa L seeds in diabetic rats
    M Kaleem
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India
    Indian J Exp Biol 44:745-8. 2006
  3. ncbi Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 5:1749-70. 2005
  4. ncbi Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats
    Ihsan Yaman
    Sivrice Vocational College, Department of Animal Breeding, Firat University, 23119 Elazig, Turkey
    Exp Toxicol Pathol 62:183-90. 2010
  5. ncbi Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    Maznah Ismail
    Nutrigenomics Program, Laboratory of Molecular Biomedicine, Institute of Bioscience, Selangor Darul Ehsan, Malaysia
    Free Radic Biol Med 48:664-72. 2010
  6. ncbi The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial
    Mohammad H Boskabady
    Department of Physiology, Medical School, and Pharmacological Research Centre of Medical Plants, Mashhad University of Medical Sciences, Mashhad, Iran
    J Altern Complement Med 14:1137-44. 2008
  7. pmc Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia
    Eyad M Salem
    Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    Saudi J Gastroenterol 16:207-14. 2010
  8. ncbi Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death
    S H Mousavi
    Department of Pharmacology and Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences MUMS, Mashhad, Iran
    Cell Mol Neurobiol 30:591-8. 2010
  9. ncbi Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
    Abdullah O Bamosa
    Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    Indian J Physiol Pharmacol 54:344-54. 2010
  10. ncbi An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols
    Alireza Ghannadi
    Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    J Med Food 8:488-93. 2005

Research Grants

  1. Annual Midwest DNA Repair Symposium
    Altaf Wani; Fiscal Year: 2007

Detail Information

Publications186 found, 100 shown here

  1. ncbi Pharmacological and toxicological properties of Nigella sativa
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 17:299-305. 2003
    The seeds of Nigella sativa Linn...
  2. ncbi Biochemical effects of Nigella sativa L seeds in diabetic rats
    M Kaleem
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India
    Indian J Exp Biol 44:745-8. 2006
    ..The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats...
  3. ncbi Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 5:1749-70. 2005
    ..Seeds of Nigella sativa, a dicotyledon of the Ranunculaceae family, have been employed for thousands of years as a spice and food ..
  4. ncbi Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats
    Ihsan Yaman
    Sivrice Vocational College, Department of Animal Breeding, Firat University, 23119 Elazig, Turkey
    Exp Toxicol Pathol 62:183-90. 2010
    ..In conclusion, NS acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GS both in the biochemical and histopathological parameters...
  5. ncbi Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    Maznah Ismail
    Nutrigenomics Program, Laboratory of Molecular Biomedicine, Institute of Bioscience, Selangor Darul Ehsan, Malaysia
    Free Radic Biol Med 48:664-72. 2010
    The antioxidant activities of the thymoquinone-rich fraction (TQRF) extracted from Nigella sativa and its bioactive compound, thymoquinone (TQ), in rats with induced hypercholesterolemia were investigated...
  6. ncbi The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial
    Mohammad H Boskabady
    Department of Physiology, Medical School, and Pharmacological Research Centre of Medical Plants, Mashhad University of Medical Sciences, Mashhad, Iran
    J Altern Complement Med 14:1137-44. 2008
    ..relaxant, anticholinergic (functional antagonism), and antihistaminic effects of various extracts and oils of Nigella sativa seed have been demonstrated...
  7. pmc Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia
    Eyad M Salem
    Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    Saudi J Gastroenterol 16:207-14. 2010
    ..Antibiotic resistance against H. pylori is increasing, and it is necessary to find new effective agents. Nigella sativa seed (NS), a commonly used herb, possesses in vitro anti-helicobacter activity...
  8. ncbi Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death
    S H Mousavi
    Department of Pharmacology and Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences MUMS, Mashhad, Iran
    Cell Mol Neurobiol 30:591-8. 2010
    ..b>Nigella sativa L...
  9. ncbi Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
    Abdullah O Bamosa
    Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    Indian J Physiol Pharmacol 54:344-54. 2010
    ..b>Nigella sativa seeds were used as an adjuvant therapy in patients with diabetes mellitus type 2 added to their anti-diabetic ..
  10. ncbi An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols
    Alireza Ghannadi
    Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    J Med Food 8:488-93. 2005
    Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols...
  11. ncbi Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial
    Waris Qidwai
    1 Department of Family Medicine, Aga Khan University, Stadium RoadP O Box 3500, Karachi 74800, Pakistan
    J Altern Complement Med 15:639-44. 2009
    The seed extracts from Nigella sativa is used by Unani physicians of traditional medicine (Hakims or Tabibs) and Ayurvedic practitioners (Vaids) in the treatment of several medical disorders including dyslipidemia, obesity, and ..
  12. ncbi The effect of Nigella sativa oil on gentamicin nephrotoxicity in rats
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem Branch, Saudi Arabia
    Am J Chin Med 32:49-55. 2004
    ..The seeds and oil of Nigella sativa are reported to possess strong antioxidant properties and was effective against disease and chemically-induced ..
  13. ncbi Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats
    Saleh C El-Saleh
    Department of Medical Microbiology, College of Sciences, King Saud University, P O Box 237, Buraidah 81999, Saudi Arabia
    Int J Cardiol 93:19-23. 2004
    ..Here we show that active antioxidant components of the traditionally used black seeds of Nigella sativa plant protect against the development of methionine-induced HHcy and its associated state of oxidative stress...
  14. ncbi The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats
    Yukse Kocyigit
    Department of Physiology, Medical Faculty, Dicle University Diyarbakir, Turkey
    Saudi Med J 30:893-6. 2009
    To investigate the effect of oral treatment of Wistar albino rats with different doses of Nigella sativa L. (NS) powdered seeds on the levels of serum lipids.
  15. ncbi Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats
    Bouchra Meddah
    Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, université Mohammed V Souissi, Rabat, Morocco
    J Ethnopharmacol 121:419-24. 2009
    b>Nigella sativa L. (Ranunculaceae) seeds have been used traditionally for centuries, notably for treating diabetes.
  16. ncbi Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats
    Mehmet Kanter
    Department of Histology Embryology, Veterinary Medicine, Yuzuncu Yil University, Van, Turkey
    Tohoku J Exp Med 201:213-9. 2003
    ..More studies are needed to demonstrate the exact mechanism of action of N. sativa L. on ameliorated blood glucose concentration in STZ-induced diabetes...
  17. ncbi The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production
    M Saeed Mahmood
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 17:921-4. 2003
    The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide (NO) production by murine macrophages was studied...
  18. ncbi Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats
    F Isik
    Faculty of Dentistry, Department of Biochemistry, Marmara University, Nisantasi, 34365, Istanbul, Turkey
    Dig Dis Sci 56:721-30. 2011
    The pathogenesis and treatment of ulcerative colitis remain poorly understood. The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on rats with colitis.
  19. ncbi Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    Sara Rooney
    Department of Zoology, University College Dublin, Belfield, Dublin 4, Ireland
    Anticancer Res 25:2199-204. 2005
    The separate effects of alpha-hederin and thymoquinone, the two principal bioactive constituents of Nigella sativa, on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) ..
  20. ncbi Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, PO Box 1365 91775, Mashhad, IR Iran
    Phytomedicine 14:621-7. 2007
    It has been previously reported that Nigella sativa oil (NSO) and thymoquinone (TQ), active constituent of N. sativa seeds oil, may prevent oxidative injury in various models...
  21. ncbi Anticancer activity of Nigella sativa (black seed) - a review
    Mohammad Akram Randhawa
    Department of Pharmacology, College of Medicine, University of Dammam, Saudi Arabia
    Am J Chin Med 39:1075-91. 2011
    b>Nigella sativa (N. sativa) seed has been an important nutritional flavoring agent and natural remedy for many ailments for centuries in ancient systems of medicine, e.g. Unani, Ayurveda, Chinese and Arabic Medicines...
  22. ncbi The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate
    Heba S Aboul Ezz
    Laboratory of Neurophysiology, Zoology Department, Faculty of Science, Cairo University, Giza, Egypt
    Neurochem Res 36:2195-204. 2011
    ..The present study aims to evaluate the antioxidant effects of curcumin, Nigella sativa oil (NSO) and valproate on the levels of malondialdehyde, nitric oxide, reduced glutathione and the activities ..
  23. ncbi Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis
    Valeelat O Okeola
    Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Parasitol Res 108:1507-12. 2011
    The antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (MENS) were investigated against established malaria infection in vivo using Swiss albino mice...
  24. ncbi Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male
    E A Datau
    Department of Internal Medicine, Sam Ratulangi University School of Medicine Prof Dr RD Kandou General Hospital, Jl Raya Tanawangko, Manado, North Sulawesi, Indonesia
    Acta Med Indones 42:130-4. 2010
    to study the efficacy of Nigella sativa in central obese men on serum free testosterone, body weight, waist circumference, blood sugar, lipid, uric acid, adiponectin, hs-CRP, and side effects in the treatment group compare to control.
  25. ncbi Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension
    Farshad Roghani Dehkordi
    Department of Internal Medicine and Cardiology and Medicinal Plant Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
    Fundam Clin Pharmacol 22:447-52. 2008
    ..a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of treatment with an oral Nigella sativa (NS) seed extract supplement in patients with mild HT...
  26. ncbi Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats
    Dalal Al-Johar
    Department of Biochemistry, College of Science, King Saud University, P O Box 2455, Riyadh 11451, Saudi Arabia
    Phytother Res 22:1311-23. 2008
    This study examined the chemopreventive effect of Nigella sativa and some of its antioxidant constituents on a number of colon cancer biomarkers in rats induced with azoxymethane (AOM)...
  27. ncbi Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice
    H Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Phytomedicine 11:56-64. 2004
    The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizure models...
  28. ncbi Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Neurochem Res 33:579-88. 2008
    The aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and derived thymoquinone (TQ) on neurodegeneration in hippocampus after chronic toluene exposure in rats...
  29. ncbi Prophylactic effect of green tea and Nigella sativa extracts against fenitrothion-induced toxicity in rat parotid gland
    Nahed S Korany
    Oral Biology Department, Faculty of Oral and Dental Medicine, Cairo University, 51 El Hadara st, Nerco, Degla, Cairo, Egypt
    Arch Oral Biol 56:1339-46. 2011
    ..The aim of the present study was to compare between two antioxidant treatments in prevention of fenitrothion induced toxicity on rat parotid salivary gland...
  30. ncbi Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats
    Mohamed E Assayed
    Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Menoufiya University Sadat City Branch, Sadat City, Egypt
    Immunopharmacol Immunotoxicol 32:284-96. 2010
    ..Wistar rats, divided into 4 groups, 15 each, were designed as I-control rats, II-rats orally intubated with Nigella sativa oil (1 ml/kg b.wt...
  31. ncbi Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
    M H Boskabady
    Department of Physiology, Medical School and Pharmacology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytomedicine 17:707-13. 2010
    In the present study, the antiasthmatic (bronchodilatory) effect of the boiled extract of Nigella sativa in the airways of asthmatic patients was examined...
  32. ncbi Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin
    G Lupidi
    Dipartimento di Biologia M C A, Universita degli Studi di Camerino, Camerino, Italy
    Phytomedicine 17:714-20. 2010
    Thymoquinone (TQ) is the main constituent of Nigella sativa essential oil which shows promising in vitro and in vivo antineoplastic growth inhibition against various tumor cell lines...
  33. ncbi Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug
    Yamini B Tripathi
    Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India
    Indian J Exp Biol 50:413-8. 2012
    ..Its mechanism of action was proposed primarily through its antioxidant potential and not through direct inhibition of other kinases, involved in its signaling cascade...
  34. ncbi A study of the chemical composition of black cumin oil and its effect on penetration enhancement from transdermal formulations
    Saima Amin
    Department of Pharmaceutics, Hamdard University, New Delhi 110062, India
    Nat Prod Res 24:1151-7. 2010
    The chemical composition of the solvent extracted fixed oil of black cumin (Nigella sativa L.) seeds was determined by capillary GC and GC/MS. Thirty-two fatty acids (99.9%) have been identified in the fixed oil...
  35. ncbi The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures
    Javad Akhondian
    Department of Pediatrics and Pediatric Neurology, Mashhad University of Medical Sciences, Ghaem Medical Center, Mashhad, Iran
    Med Sci Monit 13:CR555-9. 2007
    ..However, in traditional medicine, Nigella Sativa L. ("black cumin seed") has been known for its anticonvulsant effects...
  36. ncbi The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs
    Rana Keyhanmanesh
    Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
    Planta Med 76:218-22. 2010
    In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic, effects of Nigella sativa have been demonstrated on guinea pig tracheal chains...
  37. pmc Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig
    Mohammad H Boskabady
    Dept of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    BMC Pharmacol 4:3. 2004
    In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains...
  38. ncbi The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
    Fundam Clin Pharmacol 21:559-66. 2007
    In previous studies, the relaxant, anticholinergic (functional antagonism) antihistaminic, effects of Nigella sativa have been demonstrated on guinea-pig tracheal chains...
  39. ncbi Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone
    Salih Hamad Mohamad Aljabre
    Department of Dermatology, College of Medicine, King Faisal University, P O Box 10011, Dammam 31442, Saudi Arabia
    J Ethnopharmacol 101:116-9. 2005
    The antifungal activity of ether extract of Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of Trichophyton rubrum and one each of Trichophyton interdigitale, ..
  40. ncbi Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s)
    Mohammad Hossein Boskabady
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Indian J Exp Biol 46:805-10. 2008
    ..The results showed relaxant effect of most fractions from N. sativa on tracheal chains of guinea pigs which was more potent for methanol and dichloromethane fractions...
  41. ncbi Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L
    Lori Rastogi
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Center, Mumbai, India
    Int J Radiat Biol 86:719-31. 2010
    An ethanolic extract of Nigella sativa L. (EE-NS) was investigated for its antioxidant properties and radioprotective effects against gamma-radiation-induced oxidative damage.
  42. ncbi Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella Sativa extracts and formulations
    Reelma M Velho-Pereira
    Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz E, Mumbai 400 098, India
    Phytochem Anal 22:367-73. 2011
    ..interest in naturally occurring phytochemicals with anticancer potential has led to the discovery of many molecules, one of them being thymoquinone (TQ) the bioactive constituent of the volatile oil of black seed, Nigella sativa L. (NS).
  43. ncbi Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study
    Tamer A Gheita
    Faculty of Medicine, Cairo University, Egypt
    Phytother Res 26:1246-8. 2012
    The constituents of Nigella sativa modulate the immune system. The aim of the present work was to study the effectiveness of Nigella sativa oil in RA patients...
  44. ncbi The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Postal Code 9177948564, Mashhad, Iran
    J Ethnopharmacol 137:1028-34. 2011
    ETHNOMEDICAL RELEVANCE: The anti-inflammatory activity of both systemic and local administrations of essential oil from Nigella sativa L. has been shown.
  45. ncbi Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice
    Ahmed O Abdel-Zaher
    Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
    Neurochem Res 35:1557-65. 2010
    The effects of Nigella sativa oil on morphine-induced tolerance and dependence in mice and possible mechanism(s) of these effects were investigated, for the first time, in this study...
  46. ncbi Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma
    Ayman Talatt Abbas
    Biotechnology Research Unit, Gastro enterology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Egypt J Immunol 12:95-102. 2005
    It has been reported that Nigella sativa oil possesses anti-inflammatory and bronchodilator activities. Besides, non - toxic and wide margin of safety for therapeutic doses compared with Dexamethasone...
  47. ncbi Effect of Nigella sativa and Allium cepa oils on Trichinella spiralis in experimentally infected rats
    Nadia M T Abu El Ezz
    Department of Parasitology and Animal Diseases, National Research Center, Dokki, Giza, Egypt
    J Egypt Soc Parasitol 35:511-23. 2005
    ..sativa oil. In conclusion, N. sativa and A. cepa oils have anthelmintic effect in the rats infected with T. spiralis infection and increased the production of antibodies generated during life cycle of this parasite...
  48. ncbi Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage
    Mastour S Al-Ghamdi
    Department of Pharmacology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    Am J Chin Med 31:721-8. 2003
    It has been reported that Nigella sativa oil possesses hepatoprotective effects in some models of liver toxicity. However, it is N. sativa seeds that are used in the treatment of liver ailments in folk medicine rather than its oil...
  49. ncbi Nigella sativa: reduces the risk of various maladies
    Masood Sadiq Butt
    National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
    Crit Rev Food Sci Nutr 50:654-65. 2010
    ..Numerous plants have been tested for their therapeutic potential; Nigella sativa, commonly known as black cumin, is one of them...
  50. ncbi Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients
    Hülya Işik
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Istanbul, Turkey
    Med Princ Pract 19:206-11. 2010
    To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis.
  51. ncbi Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats
    Mehmet Fatih Altan
    Department of Civil Engineering, Faculty of Engineering, Zonguldak Karaelmas University, Zonguldak, Turkey
    Acta Histochem 109:304-14. 2007
    Extracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties...
  52. ncbi Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats
    Mousa Al Reza Hadjzadeh
    Department of Physiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
    Urol J 4:86-90. 2007
    The aim of this study was to investigate the effects of the ethanolic extract of Nigella sativa L (NS) seeds on kidney calculi in rats.
  53. ncbi The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Int Immunopharmacol 11:250-4. 2011
    ..Thymoquinone, a constituent of Nigella sativa (black seed), holds exceptional promise as an anti-cancer and anti-inflammatory agent...
  54. ncbi Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa
    N Khan
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi 110 062, India
    Eur J Cancer Prev 14:159-68. 2005
    In an earlier communication we reported that Nigella sativa suppresses potassium bromate-induced renal oxidative damage...
  55. ncbi Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods
    L Kokoska
    Department of Crop Sciences and Agroforestry, Institute of Tropics and Subtropics, Czech University of Life Sciences Prague, Kamycka 129, 165 21 Prague 6 Suchdol, Czech Republic
    J Food Prot 71:2475-80. 2008
    b>Nigella sativa L...
  56. ncbi Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets
    Halima Rchid
    Laboratoire de Recherche sur les Substances Naturelles Vegetales, Université Montpellier II UPRES EA 1677, Place E Bataillon, BAT 15, CC 024, 34095 Montpellier Cedex 05, France
    Fundam Clin Pharmacol 18:525-9. 2004
    b>Nigella sativa L. 'Black cumin' (Ranunculaceae) is one of the plants commonly used in Moroccan folk medicine for treatment of various ailments including diabetes mellitus...
  57. ncbi Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug
    Valiollah Hajhashemi
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746 73461, Iran
    Phytother Res 18:195-9. 2004
    The steam-distilled essential oil of Iranian black cumin seed (Nigella sativa L.) was investigated for its composition and analgesic and antiinflammatory properties...
  58. ncbi Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract
    M Dirjomuljono
    Department of Ear, Nose, Throat, Faculty of Medicine, University of Airlangga Dr Soetomo General Hospital, Surabaya, Jakarta, Indonesia
    Int J Clin Pharmacol Ther 46:295-306. 2008
    ..NSPN extract containing Nigella sativa and Phyllanthus niruri extracts has both antiinflammatory and immunomodulatory effects...
  59. ncbi Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats
    Alpaslan Terzi
    Department of General Surgery, Medical Faculty, Harran University, Sanliurfa, Turkey
    J Invest Surg 23:21-7. 2010
    In previous studies, it has been demonstrated that Nigella Sativa (NS) has protective effects against ischemia reperfusion injury on various organs...
  60. ncbi Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Neurochem Res 33:87-96. 2008
    The aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and thymoquinone (TQ) on histopathological changes of sciatic nerves in streptozotocin-induced diabetic rats...
  61. ncbi Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis
    M A Abdel-Wahhab
    Food Toxicology and Contaminants Dept, National Research Centre, Dokki, Cairo, Egypt
    J Appl Toxicol 25:218-23. 2005
    ..b>Nigella sativa (black cumin) and Syzygium aromaticum (clove) oil are used for the treatment of inflammatory diseases and have ..
  62. ncbi In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses
    Petr Marsik
    Department of Plant Tissue Cultures, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Planta Med 71:739-42. 2005
    ..sativa and suggest that these agents should be further studied for possible use as non-steroidal anti-inflammatory drugs...
  63. ncbi Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells
    Sara Rooney
    Department of Zoology, University College Dublin, Belfield, Dublin 4, Ireland
    Anticancer Res 25:4255-9. 2005
    Our previous studies on active constituents of Nigella sativa have indicated that cell death induced by thymoquinone and alpha-hederin was dose- and time-dependent, in a range of four cancer cell lines...
  64. ncbi Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis
    Elsayed I Salim
    Laboratory of Experimental and Molecular Carcinogenesis, Department of Zoology, Faculty of Science, Tanta University, Tanta 31527 Egypt
    Nutr Cancer 45:195-202. 2003
    Chemopreventive effects of orally administered Nigella sativa oil on the induction and development of 1,2-dimethylhydrazine-induced aberrant crypt foci (ACF), putative preneoplastic lesions for colon cancer, were investigated in Fischer ..
  65. ncbi Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    World J Gastroenterol 11:6684-8. 2005
    To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl(4)-treated rats.
  66. ncbi Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil
    Mohamed F Ramadan
    Institute of Food Chemistry, Technical University of Berlin, Gustav Meyer Allee 25, TIB 4 3 1, D 13355 Berlin, Germany
    Nahrung 46:240-4. 2002
    Black cumin (Nigella sativa L.) seed oil was extracted with two different solvents, n-hexane (H) and a mixture of chloroform/methanol (CM) (2:1, by volume). Amount of total lipid (TL) was higher in the CM miscelle (39...
  67. ncbi Anti-tumor properties of blackseed (Nigella sativa L.) extracts
    L Ait Mbarek
    Laboratory of Immunology, Biochemistry and Molecular Biology, Faculty of Sciences and Technologies, Cadi Ayyad University, Beni Mellal, Morocco
    Braz J Med Biol Res 40:839-47. 2007
    The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0...
  68. ncbi Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats
    M Kanter
    Faculty of Veterinary Medicine, Van, Turkey
    J Vet Med A Physiol Pathol Clin Med 50:264-8. 2003
    This study was designed to investigate the effects Nigella sativa L. (NS) and Urtica dioica L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl4)-treated rats...
  69. ncbi Protective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposure
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Neurochem Res 33:2241-9. 2008
    The goal of this study was designed to evaluate the possible protective effects of Nigella sativa (NS) on the neuronal injury in the frontal cortex and brain stem after chronic toluene exposure in rats...
  70. ncbi Neuropharmacological activity of Nigella sativa L. extracts
    T B Al-Naggar
    Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Ethnopharmacol 88:63-8. 2003
    Pharmacological studies have been conducted on the aqueous and methanol extracts of defatted Nigella sativa L. seeds to evaluate their effects on the central nervous system (CNS) and on analgesic activity...
  71. ncbi The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats
    M K Türkdoğan
    Division of Gastroenterology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey
    Phytother Res 17:942-6. 2003
    The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis and cirrhosis...
  72. ncbi Protective effect of Nigella sativa seeds against lead-induced hepatorenal damage in male rats
    Abdel Razik H Farrag
    Department of Pathology, Assiut University, Egypt
    Pak J Biol Sci 10:2809-16. 2007
    ..The present study was carried out to investigate the possible protective effect of co-administered Nigella sativa seeds on lead acetate-induced rats' toxicity in particularly on liver and kidney...
  73. ncbi Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases
    Ulrich Kalus
    Humboldt University, Berlin, School of Medicine, Institute for Transfusion Medicine, Charite University Hospital, Berlin, Germany
    Phytother Res 17:1209-14. 2003
    b>Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies...
  74. ncbi Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats
    Amir Hamzo Dahri
    Department of Pathology, Peoples Medical College, Nawabshah
    J Ayub Med Coll Abbottabad 17:72-4. 2005
    ..The effect of Nigella sativa on levels of cholesterol fractions were determined in this study on rats.
  75. pmc Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver
    Fahrettin Yildiz
    Harran University Medical Faculty, Department of General Surgery, Sanliurfa 63300, Turkey
    World J Gastroenterol 14:5204-9. 2008
    To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver.
  76. ncbi Evaluation of cytological effects of Zn2+ in relation to germination and root growth of Nigella sativa L. and Triticum aestivum L
    A A El-Ghamery
    Botany and Microbiology Department, Faculty of Science, Al Azhar University, Nasr City, 11884, Cairo, Egypt
    Mutat Res 537:29-41. 2003
    The effects of different treatments with zinc sulfate (Zn(2+)) on the cytology and growth of Nigella sativa and Triticum aestivum were investigated...
  77. ncbi The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat
    Phuong Mai Le
    Department of Pharmacology, Universite de Montreal, PO Box 6128, Downtown Station, Quebec, Canada H3C 3J7
    J Ethnopharmacol 94:251-9. 2004
    We studied the effect of a 4-week intragastric gavage with a petroleum ether extract of Nigella sativa seeds on blood glucose, insulin and lipids in the normal rat...
  78. ncbi Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells
    Ibrahim O Farah
    Jackson State University, Jackson, MS 39217, USA
    Biomed Sci Instrum 39:359-64. 2003
    ..Sativa alone or in combination with oxidative stress were found to be effective in vitro in inactivating MCF-7 breast cancer cells, unveiling opportunities for promising results in the field of prevention and treatment of cancer...
  79. ncbi The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds
    M A U Khan
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 17:183-6. 2003
    The effect of an aqueous extract of Nigella sativa seeds was studied on candidiasis in mice. An intravenous inoculum of Candida albicans produced colonies of the organism in the liver, spleen and kidneys...
  80. ncbi Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats
    Amein Al-Ali
    Department of Biochemistry, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    J Ayub Med Coll Abbottabad 20:25-7. 2008
    Thymoquinone is the major active principle of Nigella sativa (N. sativa) and constitutes about 30% of its volatile oil or ether extract. N. sativa oil and seed are commonly used as a natural remedy for many ailments...
  81. ncbi Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models
    Ibrahim Tekeoglu
    Yuzuncu Yil University, Medical School, Department of Rehabilitation and Rheumatology, Turkey
    Phytother Res 21:895-7. 2007
    Many studies have been carried out in recent years on the pharmacological effects of Nigella sativa seeds that have uncovered their antiinflammatory and immunological effects...
  82. ncbi Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
    1. The present study investigated the possible protective effects of thymoquinone (TQ), a compound derived from Nigella sativa with strong anti-oxidant properties, against gentamicin (GM)-induced nephrotoxicity. 2...
  83. ncbi Effects of Nigella sativa and human parathyroid hormone on bone mass and strength in diabetic rats
    Mehmet Fatih Altan
    Department of Civil Engineering, Faculty of Engineering, Zonguldak Karaelmas University, Zonguldak, Turkey
    Biol Trace Elem Res 116:321-8. 2007
    ..Recently, many therapeutic effects of Nigella sativa L...
  84. ncbi The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs
    Boskabady Mohammad Hossein
    Department of Physiology and Pharmacological Research Center of Medicinal Plants, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Exp Lung Res 34:183-94. 2008
    ..However, the protective effect of Nigella sativa on inflammatory process was shown...
  85. ncbi Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates
    Shala S El Wakil
    Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
    J Egypt Soc Parasitol 37:801-13. 2007
    The effect of Nigella sativa aqueous extract was evaluated against the in vitro growth of 2 different isolates of the intestinal protozoan parasite Blastocystis hominis...
  86. ncbi Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells
    Ahmed Amir Radwan Sayed
    Chemistry Department, Faculty of Science, Minia University, El Minia 61519, Egypt
    Phytother Res 21:898-9. 2007
    ..A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ...
  87. ncbi The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells
    Nourelhoda Farah
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 41:211-6. 2005
    ..The objective of the study was to determine the safety of the fractionated compounds and compare their potency with pure thymoquinone and vitamin E on A549 cells in culture for 24, 48 and 72 hours...
  88. ncbi Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress
    Naghma Khan
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India
    Hum Exp Toxicol 22:193-203. 2003
    Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats...
  89. ncbi Effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase activity
    Rachid Kacem
    Department of Biological Sciences, Faculty of Sciences, Ferhat Abbas University, Setif, Algeria
    Yakugaku Zasshi 126:301-5. 2006
    The effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase (HNE) activity were investigated. Essential oil was extracted from N. sativa (L.) seeds using hydrodistillation...
  90. ncbi Thymoquinone is a potent superoxide anion scavenger
    Osama A Badary
    Department of Pharmacology and Toxicology, College of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Drug Chem Toxicol 26:87-98. 2003
    ..The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals. Moreover, the data indicate that TQ is acting mainly as a potent superoxide anion scavenger...
  91. pmc The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model
    Mohamad A Abd el-Aziz
    Department of Biochemistry, Al Azhar University, Egypt
    Int J Exp Pathol 86:383-96. 2005
    ..Melatonin (Mel), retinoic acid (RA) and Nigella sativa (NS) are substances with anticancer effects...
  92. ncbi A simple differential pulse polarographic method for the determination of thymoquinone in black seed oil
    Astrid Michelitsch
    Institut für Pharmazeutische Chemie und Pharmazeutische Technologie der Karl Franzens Universität Graz, Schubertstrasse 1, A 8010 Graz, Austria
    Phytochem Anal 14:224-7. 2003
    ..0 microg/mL (R = 0.9998). The limit of detection was calculated to be 0.054 microg/mL. The polarographic method has been applied to determine thymoquinone in two black seed oil preparations available on the Austrian pharmaceutical market...
  93. ncbi Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran
    Bahman Nickavar
    Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, PO Box 14155 6153, Tehran, Iran
    Z Naturforsch C 58:629-31. 2003
    The chemical composition of the extracted fixed oil (total fatty acid composition) and volatile oil of Nigella sativa L. seeds grown in Iran were determined by GC and GC/MS. Eight fatty acids (99.5%) and thirty-two compounds (86...
  94. ncbi Immunosuppressive and cytotoxic properties of Nigella sativa
    Sk Nazrul Islam
    Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh
    Phytother Res 18:395-8. 2004
    In this study the volatile oil of Nigella sativa seeds (NSVO) was investigated for its immunomodulating and cytotoxic properties. A rat model was designed to examine the effect of NSVO on selected immune components...
  95. ncbi Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats
    Mehmet Kanter
    Department of Medical Histology and Embryology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
    Anat Rec A Discov Mol Cell Evol Biol 279:685-91. 2004
    The aim of the present study was to evaluate the possible protective effects of Nigella sativa L. (NS) against beta-cell damage from streptozotocin (STZ)-induced diabetes in rats...
  96. ncbi New fatty acid esters originate during storage by the interaction of components in prasaplai, a Thai traditional medicine
    Somsak Nualkaew
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Planta Med 70:1243-6. 2004
    ..A systematic search indicated that the three esters arose from the interaction of compounds contained in the rhizomes of Zingiber cassumunar and the seeds of Nigella sativa.
  97. ncbi In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil
    E M Awad
    Department of Zoology, Faculty of Science, University of Minia, Minia, Egypt
    Phytomedicine 12:100-7. 2005
    ..In the present study, Nigella sativa oil (NSO) was studied to evaluate its effect on the fibrinolytic potential of the fibosarcoma cell line HT1080 ..
  98. ncbi The role of black seed in the proliferation and biochemical marker levels of Hep-2 cells
    Jeffrey T Hansen
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 39:371-6. 2003
    For centuries, people in the Middle East and Southeast Asia have used Nigella sativa, also known as black seed (BS), for its homeopathic effects...
  99. ncbi Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models
    Ibrahim Tekeoglu
    Yuzuncu Yil University, Medical School, Department of Rehabilitation and Rheumatology, Maras cad 65100, Van, Turkey
    Phytother Res 20:869-71. 2006
    Many studies have been carried out in recent years on the pharmacological effects of nigella sativa seeds that have uncovered their antiinflammatory and immunological effects...
  100. ncbi Effect of Nigella sativa on blood hemostatic function in rats
    S A Al-Jishi
    Department of Physiology, King Faisal University, P O Box 2114, Dammam 31451, Saudi Arabia
    J Ethnopharmacol 85:7-14. 2003
    b>Nigella sativa (NS) is consumed excessively in Saudi Arabia and Gulf Countries but few studies were conducted on its effects on hemostasis...
  101. ncbi Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures
    M Khader
    Division of Genetics, Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    J Ethnopharmacol 112:199-202. 2007
    Aqueous extracts of Nigella sativa (Ranunculaceae) (Ns), Teucrium polium (Labiatae) (Tp) and Trigonella foenum-graecum (Fabaceae) (Tf) have been traditionally used to treat inflammations, liver disorders, and arthritis...

Research Grants1

  1. Annual Midwest DNA Repair Symposium
    Altaf Wani; Fiscal Year: 2007
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