soy foods

Summary

Summary: Foods made from SOYBEANS. Health benefits are ascribed to the high levels of DIETARY PROTEINS and ISOFLAVONES.

Top Publications

  1. ncbi Soy and isoflavone consumption in relation to prostate cancer risk in China
    Marion M Lee
    Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 12:665-8. 2003
  2. ncbi Soyfood intake and breast cancer survival: a followup of the Shanghai Breast Cancer Study
    Sonia M Boyapati
    Division of General Internal Medicine, Department of Medicine, Center for Health Service Research, Vanderbilt University, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 92:11-7. 2005
  3. ncbi Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies
    Ye Won Hwang
    Graduate School of Public Health, Yonsei University, Seoul, Korea
    Nutr Cancer 61:598-606. 2009
  4. ncbi Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies
    Jeongseon Kim
    Cancer Epidemiology Branch, Research Institute, National Cancer Center, Goyang, Korea
    Cancer Sci 102:231-44. 2011
  5. ncbi Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status
    Caixia Zhang
    Centre of Research and Promotion of Women s Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong
    Cancer Sci 101:501-7. 2010
  6. pmc Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer
    Wang Hong Xu
    Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Am J Epidemiol 166:1420-30. 2007
  7. ncbi Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults
    Fang Hsuean Liao
    School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China
    Nutrition 23:551-6. 2007
  8. ncbi Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 167:1060-7. 2007
  9. ncbi Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort
    Kwang Pil Ko
    Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehangno, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 19:1292-300. 2010
  10. pmc Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women
    Barbara J Fuhrman
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5003, Rockville, MD 20852 7246, USA
    Cancer Epidemiol Biomarkers Prev 18:2751-60. 2009

Detail Information

Publications246 found, 100 shown here

  1. ncbi Soy and isoflavone consumption in relation to prostate cancer risk in China
    Marion M Lee
    Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 12:665-8. 2003
    ..Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database ..
  2. ncbi Soyfood intake and breast cancer survival: a followup of the Shanghai Breast Cancer Study
    Sonia M Boyapati
    Division of General Internal Medicine, Department of Medicine, Center for Health Service Research, Vanderbilt University, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 92:11-7. 2005
    ..These data suggest that soyfoods do not have an adverse effect on breast cancer survival...
  3. ncbi Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies
    Ye Won Hwang
    Graduate School of Public Health, Yonsei University, Seoul, Korea
    Nutr Cancer 61:598-606. 2009
    ..The summary ORs (95% CI) for total soy foods were 0.69 (CI = 0.57-0.84) and 0.75 (CI = 0.62-0.89) for nonfermented soy foods...
  4. ncbi Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies
    Jeongseon Kim
    Cancer Epidemiology Branch, Research Institute, National Cancer Center, Goyang, Korea
    Cancer Sci 102:231-44. 2011
    ..Japanese and Korean populations have high incidence rates of GC despite the consumption of a wide variety of soy foods. One primary reason is that they consume fermented rather than non-fermented soy foods...
  5. ncbi Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status
    Caixia Zhang
    Centre of Research and Promotion of Women s Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong
    Cancer Sci 101:501-7. 2010
    ..This study suggests that consumption of soy food, soy isoflavone, is inversely associated with the risk of breast cancer. The protective effects of soy did not seem to differ by ER and PR breast cancer status...
  6. pmc Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer
    Wang Hong Xu
    Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Am J Epidemiol 166:1420-30. 2007
    ..Higher intake of soy foods and tea consumption were both inversely associated with the risk of endometrial cancer, with odds ratios of 0...
  7. ncbi Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults
    Fang Hsuean Liao
    School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China
    Nutrition 23:551-6. 2007
    ..This study investigated the effects of a soy-based low-calorie diet on weight control, body composition, and blood lipid profiles compared with a traditional low-calorie diet...
  8. ncbi Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 167:1060-7. 2007
    ..For people aged 40 to 70 years, each increment of 20 mm Hg in systolic blood pressure (BP) or 10 mm Hg in diastolic BP doubles the risk of cardiovascular disease for BPs of 115/75 to 185/115 mm Hg...
  9. ncbi Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort
    Kwang Pil Ko
    Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehangno, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 19:1292-300. 2010
    ..To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study...
  10. pmc Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women
    Barbara J Fuhrman
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5003, Rockville, MD 20852 7246, USA
    Cancer Epidemiol Biomarkers Prev 18:2751-60. 2009
    ..In a sample of Asian-American women, we investigated the associations of usual adult soy intake with the urinary concentrations of 15 estrogens and estrogen metabolites (EM) measured using liquid chromatography-tandem mass spectrometry...
  11. pmc Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis
    Gong Yang
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203 1738, USA
    Am J Epidemiol 176:846-55. 2012
    ..This study suggests that soy food consumption may reduce lung cancer risk in nonsmoking women, particularly for aggressive tumors, and its effect may be modified by endogenous estrogens...
  12. ncbi Isoflavonoid content of Hong Kong soy foods
    Sieu G Chan
    Department of Community and Family Medicine and Centre of Research and Promotion of Women s Health, School of Public Health, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Agric Food Chem 57:5386-90. 2009
    ..The isoflavone concentrations reported herein will be useful for ascertaining the relationship between exposure to dietary soy isoflavones and health effects in the Chinese population...
  13. ncbi Bioavailability and urinary excretion of isoflavones in humans: effects of soy-based supplements formulation and equol production
    Sébastien Vergne
    ENITA, Unité Micronutriments, Reproduction, santé, Bordeaux, France
    J Pharm Biomed Anal 43:1488-94. 2007
    ..This difference disappeared when equol excretion was added to daidzein excretion in equol producers. Our results indicated that the production of equol could partly explain the difference in daidzein bioavailability after IF ingestion...
  14. ncbi Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women
    Giske Ursin
    University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 56:128-35. 2006
    ..Our results suggest that the effect of soy intake on percent mammographic density is moderate but possibly of clinical relevance...
  15. ncbi Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods
    Julia M W Wong
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
    Am J Clin Nutr 95:564-71. 2012
    Recent analyses have challenged the effectiveness of soy foods as part of a cardiovascular risk reduction diet.
  16. ncbi Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study
    Kazuko Nishio
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Causes Control 18:801-8. 2007
    ..To examine whether soy foods really have protective effects against breast cancer and how their influence on breast cancer is modified ..
  17. ncbi Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan
    Taichi Shimazu
    Research Center for Cancer Prevention and Screening, National Cancer Center Tokyo Japan
    Am J Clin Nutr 91:722-8. 2010
    Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies...
  18. ncbi UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk
    Sandra L Deming
    Vanderbilt Epidemiology Center, Department of Medicine and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 17:563-70. 2008
    ....
  19. ncbi Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice
    Vimal Selvaraj
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 71:966-72. 2004
    ....
  20. pmc The volume of nipple aspirate fluid is not affected by 6 months of treatment with soy foods in premenopausal women
    Gertraud Maskarinec
    University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    J Nutr 141:626-30. 2011
    ..50 for diet; P-interaction = 0.21 for diet with time). Contrary to an earlier report, soy foods in amounts consumed by Asians did not increase breast tissue activity as assessed by NAF volume.
  21. pmc Urinary estrogen metabolites during a randomized soy trial
    Yukiko Morimoto
    University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA
    Nutr Cancer 64:307-14. 2012
    ..The current analysis examined the effect of soy foods on the 2:16α-OH E(1) ratio among premenopausal women during a randomized, crossover intervention study; women ..
  22. pmc Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial
    Gertraud Maskarinec
    University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 20:1815-21. 2011
    On the basis of hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk.
  23. pmc Soy intake and breast cancer risk in Singapore Chinese Health Study
    A H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Br J Cancer 99:196-200. 2008
    ..These prospective findings suggest that approximately 10 mg of isoflavones per day, obtained in a standard serving of tofu, may have lasting beneficial effects against breast cancer development...
  24. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009
    ..Data from epidemiologic studies linking usual soy food intake with colorectal cancer are limited and inconsistent...
  25. ncbi Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know
    Louiza S Velentzis
    University College London, Department of Surgery, Breast Cancer Research Group, Charles Bell House, 67 73 Riding House Street, London W1W 7EJ, UK
    Eur J Cancer 44:1799-806. 2008
    ..So far, not enough clear evidence exists on which to base guidelines for clinical use, although raising patient awareness of the uncertain effect of phytoestrogens is recommended...
  26. ncbi Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
    Christopher R Cederroth
    Department of Genetic Medicine and Development, National Centre of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    Diabetes 57:1176-85. 2008
    ..Here, we investigate the mechanisms mediating the action of dietary phytoestrogens on lipid and glucose metabolism in rodents...
  27. pmc Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults
    Christopher D Gardner
    Stanford Prevention Research Center, Stanford University Medical School, CA 94305 5705, USA
    J Nutr Biochem 20:227-34. 2009
    ..the pharmacokinetics of isoflavone concentrations over a 24-h period among healthy adults consuming either soy foods or soy isoflavone tablets at different doses...
  28. ncbi Determinants for urinary and plasma isoflavones in humans after soy intake
    Adrian A Franke
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Nutr Cancer 50:141-54. 2004
    Consumption of soy foods leads to a biphasic appearance pattern of isoflavones (IFLs) in blood and urine, with peaks appearing at 1-2 h and 4-8 h after intake, but its causes are not understood...
  29. ncbi Kimchi and soybean pastes are risk factors of gastric cancer
    Hong Mei Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Kaeshin dong, Hungdok gu, Cheongju Si, Chungbuk 361 763, Korea
    World J Gastroenterol 11:3175-81. 2005
    ....
  30. ncbi The effect on the blood lipid profile of soy foods combined with a prebiotic: a randomized controlled trial
    Julia M W Wong
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada M5C 2T2
    Metabolism 59:1331-40. 2010
    ..inulin, a fermentable carbohydrate), a soy food-containing diet (30 g/d soy protein, 61 mg/d isoflavones from soy foods) and 10 g/d placebo (maltodextrin), and a soy food-containing diet with 10 g/d prebiotic--in a randomized ..
  31. ncbi Soy processing influences growth of estrogen-dependent breast cancer tumors
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:1649-57. 2004
    Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed...
  32. ncbi Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan
    Fumio Sakauchi
    Department of Public Health, Sapporo Medical University School of Medicine, Japan
    Nutr Cancer 57:138-45. 2007
    ..In contrast, however, a high intake of soy bean curd (tofu) might have preventive effects against the risk...
  33. ncbi Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis
    S K Myung
    Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea
    BJOG 116:1697-705. 2009
    ..Epidemiology studies have reported associations between soy intake and the risk of endocrine-related gynaecological cancers. However, to date there have been no quantitative meta-analyses reported regarding this topic...
  34. pmc Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis
    L Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Hum Reprod Update 15:423-40. 2009
    ..07, 21 studies). CONCLUSIONS Isoflavone-rich soy products decrease FSH and LH in premenopausal women and may increase estradiol in post-menopausal women. The clinical implications of these modest hormonal changes remain to be determined...
  35. ncbi A 2-year soy intervention in premenopausal women does not change mammographic densities
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI, USA
    J Nutr 134:3089-94. 2004
    ..The aims of this 2-y trial were to examine the effects of soy foods and lifetime soy intake on mammographic density...
  36. ncbi A newly constructed and validated isoflavone database for the assessment of total genistein and daidzein intake
    Margaret R Ritchie
    Division of Neuroscience and Pharmacology, Ninewells Hospital, Dundee, UK
    Br J Nutr 95:204-13. 2006
    ..Main food sources of isoflavones for the omnivorous group were soya yogurts, wholemeal bread and rolls, white bread and rolls, garlic bread, nan bread and brown bread, sultanas and scones...
  37. pmc Prevalence, sources, and predictors of soy consumption in breast cancer
    Carolyn A Lammersfeld
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA
    Nutr J 8:2. 2009
    ..Clinicians providing nutrition counseling to these women are concerned because the availability of soy foods has increased dramatically in the past few years...
  38. ncbi Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males
    Sébastien Vergne
    Arkopharma, Laboratoires Pharmaceutiques, Carros, France
    Br J Nutr 99:333-44. 2008
    ....
  39. ncbi Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy
    Eliana Petri Nahas
    Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University, Sao Paulo 18618 970, Brazil
    Maturitas 48:372-80. 2004
    ..To evaluate the effects of isoflavones on vasomotor symptoms and blood lipids in postmenopausal women with contraindication for conventional hormone replacement therapy (HRT)...
  40. ncbi Isoflavones from soya foods are more bioavailable in children than adults
    Brunhild M Halm
    Cancer Research Center of Hawai i, Cancer Prevention and Control Program and Kapi olani Medical Center for Women and Children, Honolulu, HI, USA
    Br J Nutr 98:998-1005. 2007
    ..Urine is an excellent medium to determine systemic isoflavone exposure in children due to its non-invasiveness and high compliance, in particular when collected overnight; it also allows evaluation of completeness of specimen collection...
  41. ncbi Associations among maternal soy intake, isoflavone levels in urine and blood samples, and maternal and umbilical hormone concentrations (Japan)
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cancer Causes Control 17:1107-13. 2006
    ..A high intake of soy has been suggested to protect against breast cancer. We examined the hypothesis that maternal soy intake may be inversely associated with pregnancy hormone levels...
  42. ncbi Fruits, vegetables, soy foods and breast cancer in pre- and postmenopausal Korean women: a case-control study
    Min Hee Do
    Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, Korea
    Int J Vitam Nutr Res 77:130-41. 2007
    We carried out a case-control study to examine the relationship between fruits, vegetables, and soy foods intake with breast cancer risk in Korean women...
  43. pmc Comparative analysis of physical maps of four Bacillus subtilis (natto) genomes
    Dongru Qiu
    Institute for Advanced Biosciences and Bioinformatics Program, Keio University, 403 1 Nipponkoku, Daihoji, Tsuruoka, Yamagata 997 0017, Japan
    Appl Environ Microbiol 70:6247-56. 2004
    ..The genome structure and gene heterogeneity were also consistent with the type of indigenous plasmids harbored by the strains...
  44. pmc The role of early life genistein exposures in modifying breast cancer risk
    A Warri
    Functional Foods Forum, University of Turku, Turku, Finland
    Br J Cancer 98:1485-93. 2008
    Review of the existing literature suggests that consumption of soy foods or an exposure to a soy isoflavone genistein during childhood and adolescence in women, and before puberty onset in animals, reduces later mammary cancer risk...
  45. ncbi Sample preparation for the analysis of isoflavones from soybeans and soy foods
    M A Rostagno
    Centro para la Calidad de los Alimentos, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Campus Universitario Duques de Soria, 42004 Soria, Spain
    J Chromatogr A 1216:2-29. 2009
    ..and future prospects in sample preparation and analysis for the quantification of isoflavones from soybeans and soy foods. Individual steps of the procedures used in sample preparation, including sample conservation, extraction ..
  46. ncbi Not all soy products are created equal: caution needed in interpretation of research results
    John W Erdman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:1229S-1233S. 2004
    Interest in the health benefits of soy foods has been intense among the research community, health professionals, and the public...
  47. pmc Epidemiology of soy exposures and breast cancer risk
    A H Wu
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9175, USA
    Br J Cancer 98:9-14. 2008
    ..8 and 0.15 mg per day, respectively. Thus, the evidence to date, based largely on case-control studies, suggest that soy food intake in the amount consumed in Asian populations may have protective effects against breast cancer...
  48. ncbi Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings
    Mark Messina
    Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA, USA
    J Natl Cancer Inst 98:1275-84. 2006
    ..This paper summarizes the workshop findings and recommendations. The primary research recommendation is that the impact of isoflavones on breast tissue needs to be evaluated at the cellular level in women at high risk for breast cancer...
  49. ncbi Serum isoflavones and soya food intake in Japanese, Thai and American end-stage renal disease patients on chronic haemodialysis
    Paolo Fanti
    University of Kentucky Medical Center, Lexington, KY 40536, USA
    Nephrol Dial Transplant 18:1862-8. 2003
    ..No information is available, however, about blood levels of soya isoflavones in ESRD patients with habitual soya intake. Additionally, no information is available about the conjugation profile of these compounds in ESRD patients...
  50. ncbi Insulin-like growth factor-1 and binding protein-3 in a 2-year soya intervention among premenopausal women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Br J Nutr 94:362-7. 2005
    ..Adding soya foods to the diet of premenopausal women does not appear to lower serum levels of IGF-1 and IGFBP-3; if anything, the greater protein intake from soya may lead to a small increase in IGF-1 serum levels...
  51. ncbi Intake of soy foods and soy isoflavones by rural adult women in China
    Zhaoping Liu
    Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing, 100050, China
    Asia Pac J Clin Nutr 13:204-9. 2004
    This study evaluated the intake of soy foods and soy isoflavones by rural adult women and potential determinant factors...
  52. ncbi Correlates of soy food consumption in women at increased risk for breast cancer
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, Cheltenham, PA 19012, USA
    J Am Diet Assoc 105:1552-8. 2005
    ..examine sociodemographic correlates of soy food consumption among women at increased risk of breast cancer, describe factors influencing soy food consumption or nonconsumption, and identify women's sources of information about soy foods.
  53. ncbi Dietary supplement with fermented soybeans, natto, improved the neurobehavioral deficits after sciatic nerve injury in rats
    Hung Chuan Pan
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
    Neurol Res 31:441-52. 2009
    ..These findings indicate that oral intake of natto has the potential to augment regeneration in peripheral nerve injury, possibly mediated by the clearance of fibrin and decreased production of TNF-alpha...
  54. pmc Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study
    Sang Ah Lee
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1920-6. 2009
    ..Soy food is a rich source of isoflavones--a class of phytoestrogens that has both antiestrogenic and anticarcinogenic properties...
  55. ncbi Urinary isoflavones and their metabolites validate the dietary isoflavone intakes in US adults
    Ock Kyoung Chun
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
    J Am Diet Assoc 109:245-54. 2009
    ..Valid and reliable estimation of isoflavone intake is a prerequisite to establishing biological functions of isoflavones on health risks...
  56. ncbi Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 136:45-51. 2006
    The precise role that isoflavones play in the health-related effects of soy foods, and their potential for adverse effects are controversial...
  57. ncbi Group B saponins in soy products in the U.S. Department of Agriculture--Iowa State University isoflavone database and their comparison with isoflavone contents
    P A Murphy
    Iowa State University, Ames, Iowa 5001, USA
    J Agric Food Chem 56:8534-40. 2008
    ..We measured the group B soyasaponin concentrations in a variety of soy foods and ingredients in the U.S. Department of AgricultureIowa State University Isoflavone Database...
  58. ncbi Soy constituents: modes of action in low-density lipoprotein management
    Jan H van Ee
    Archer Daniels Midland Company, Koog aan de Zaan, The Netherlands
    Nutr Rev 67:222-34. 2009
    ....
  59. ncbi Determination and characterization of IS4Bsu1-insertion loci and identification of a new insertion sequence element of the IS256 family in a natto starter
    Keitarou Kimura
    Division of Applied Microbiology, National Food Research Institute, Japan
    Biosci Biotechnol Biochem 71:2458-64. 2007
    ..IS256Bus1 appeared active in transposition, potentially causing phenotypic alterations in natto starters like those induced by IS4Bsu1...
  60. ncbi Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study
    Min Hee Do
    Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, Korea
    Nutr Cancer 57:20-7. 2007
    ..62; 95% CI=0.38-0.81; P<0.01). Among soy foods, high consumption of cooked soybeans, including yellow and black soybeans, had an association with reduced ..
  61. ncbi Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Clin Oncol 26:1677-83. 2008
    ..Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake...
  62. ncbi Evaluation of tissue mimicking quality of tofu for biomedical ultrasound
    Yong Tae Kim
    Division of Physical Metrology, Korea Research Institute of Standards and Science, Yusong, Daejeon, Republic of Korea
    Ultrasound Med Biol 35:472-81. 2009
    ..The present results suggest that tofu may only be used in a limited low MHz range in view of the estimation of temperature rise and penetration depth due to nonlinear frequency dependence of attenuation...
  63. ncbi Soy consumption and mortality in Hong Kong: proxy-reported case-control study of all older adult deaths in 1998
    Sai Yin Ho
    Department of Community Medicine, The University of Hong Kong, Hong Kong SAR, PR China
    Prev Med 43:20-6. 2006
    ..This study investigates the relation between soy consumption and mortality in a population-based case-control study in Hong Kong of all adult deaths in 1998...
  64. ncbi Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition
    Marian S Faughnan
    School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
    Br J Nutr 91:567-74. 2004
    ..Further studies are required to examine the effect of higher intake and define the relative influence of these factors in elderly population groups...
  65. ncbi Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china
    Min Zhang
    School of Public Health, Curtin University of Technology, Perth, WA, Australia
    Nutr Cancer 49:125-30. 2004
    ..Habitual dietary intakes including 9 soy foods were measured by face-to-face interview using a validated and reliable food-frequency questionnaire...
  66. ncbi Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 83:592-600. 2006
    The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect...
  67. pmc Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey
    Elisa V Bandera
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cancer Causes Control 20:1117-27. 2009
    ..85 (OR: 0.59; 95% CI: 0.33-1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women...
  68. pmc Determination of total soy isoflavones in dietary supplements, supplement ingredients, and soy foods by high-performance liquid chromatography with ultraviolet detection: collaborative study
    Mark W Collison
    Archer Daniels Midland Co, Research Division, Analytical Chemistry, Decatur, IL 62521 1656, USA
    J AOAC Int 91:489-500. 2008
    ..a method for determining total soy isoflavones in dietary supplements, dietary supplement ingredients, and soy foods. Isoflavones were extracted using aqueous acetonitrile containing a small amount of dimethylsulfoxide (DMSO) and ..
  69. ncbi [A study on isoflavones intake from soy foods and perimenstrual symptoms]
    Hae won Kim
    Department of Nursing, College of Medicine, Kwandong University, Korea
    Taehan Kanho Hakhoe Chi 37:276-85. 2007
    This study was conducted to explore the relationship between isoflavones intake from soy foods and perimenstrual symptoms among women.
  70. ncbi Meta-analysis of soy food and risk of prostate cancer in men
    Lin Yan
    Health and Nutrition, The Solae Company, St Louis, MO 63188, USA
    Int J Cancer 117:667-9. 2005
    ..70 (95% CI = 0.59-0.83; p < 0.001). No publication bias was detected. In summary, results of the analysis showed that consumption of soy food was associated with a lower risk of prostate cancer in men...
  71. ncbi Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 82:1260-8; quiz 1365-6. 2005
    ..The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease...
  72. ncbi Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights
    Katherine A Jackman
    Department of Pharmacology and Centre for Vascular Health, Monash University, Clayton, Victoria, Australia
    Curr Med Chem 14:2824-30. 2007
    ..Findings obtained in both animal and human studies will be reviewed with the hope of gaining an insight into the experimental and clinical importance of equol to the cardiovascular benefits of soy...
  73. ncbi Metabolism of the soy isoflavones daidzein and genistein by fungi used in the preparation of various fermented soybean foods
    Te Sheng Chang
    Department of Biological Science and Technology, National University of Tainan, Tainan, Taiwan
    Biosci Biotechnol Biochem 71:1330-3. 2007
    ..The metabolites of daidzein and genistein by Aspergillus strains were identified as 8-hydroxydaidzein and 8-hydroxygenistein, respectively, based on their mass, (1)H-, and (13)C-NMR spectra...
  74. ncbi Soy: an anticancer agent in wide use despite some troubling data
    Barrie R Cassileth
    Cancer Invest 21:817-8. 2003
  75. ncbi Re: Soy, isoflavones, and breast cancer risk in Japan
    Shuku Fujimaki
    J Natl Cancer Inst 95:1881-2; author reply 1881-2. 2003
  76. ncbi Identification of equol producers in a Japanese population by high-performance liquid chromatography with coulometric array for determining serum isoflavones
    J H Zhao
    Center for Community Medicine, Department of Environmental Medicine, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Kawachi gun, Tochigi 329 0498, Japan
    Phytomedicine 13:304-9. 2006
    ..1 ng/ml of genistein, and 9.6 ng/ml of equol. Interestingly, there existed two dominant groups in terms of serum equol concentrations in an independent manner of soy-derived product intake among the study participants...
  77. ncbi Production and processing of soybeans and nutrition and safety of isoflavone and other soy products for human health
    Myung Sook Choi
    Department of Food Science and Nutrition, College of Human Ecology, Kyungpook National University, Daegu, Korea
    J Med Food 9:1-10. 2006
    ..Some of these issues may affect the choice of raw or basic material sources, processing conditions, quality control procedures/measures, and marketing strategies for both soy-based foods and isoflavones...
  78. ncbi A soy supplement and tamoxifen inhibit sexual behavior in female rats
    Heather B Patisaul
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Horm Behav 45:270-7. 2004
    ..These results demonstrate that both the soy supplement and TAMOX act as estrogen antagonists on both proceptive and receptive behavior in female rats...
  79. ncbi Effect of water-to-bean ratio on the contents and compositions of isoflavones in tofu
    Fuh Juin Kao
    Graduate Institute of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan
    J Agric Food Chem 52:2277-81. 2004
    ....
  80. ncbi Distribution of soy-derived phytoestrogens in human breast tissue and biological fluids
    Julie Maubach
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    Obstet Gynecol 103:892-8. 2004
    ..We aimed to investigate the concentrations of genistein, daidzein, and equol in human breast tissue homogenate and to compare these with the corresponding values in serum and urine...
  81. ncbi Isoflavones inhibit nicotine C-oxidation catalyzed by human CYP2A6
    Miki Nakajima
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Clin Pharmacol 46:337-44. 2006
    ..concentrations 2 hours after chewing 1 piece of nicotine gum under the basal condition (after abstaining from soy foods for 1 week) was 8.8 +/- 2.6 (4.4-11.4). The ratio was significantly (P < .05) reduced to 6.7 +/- 1.6 (4.0-8...
  82. pmc Urinary isoflavonoid excretion is similar after consuming soya milk and miso soup in Japanese-American women
    Gertraud Maskarinec
    Cancer Research Center of Hawai i, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Br J Nutr 100:424-9. 2008
    ..Therefore, recommendations favouring fermented soya foods are not justified as long as the intestinal microflora is capable of hydrolysing the isoflavone glucosides from non-fermented soya foods...
  83. ncbi Soy and prostate cancer study results mixed
    Brian Vastag
    J Natl Cancer Inst 99:1364-5. 2007
  84. ncbi Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii
    G Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Eur J Clin Nutr 61:255-61. 2007
    ....
  85. ncbi How isoflavone levels in common rodent diets can interfere with the value of animal models and with experimental results
    M Nygaard Jensen
    Central Animal Facility, University Medical Center, St Radboud, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Lab Anim 41:1-18. 2007
    ..The levels of isoflavones in common laboratory diets are reviewed in relation to the dietary levels influencing different endpoints...
  86. ncbi Soy isoflavone consumption is not associated with increased risk of advanced prostate cancer
    Maarten C Bosland
    Cancer Epidemiol Biomarkers Prev 16:2169; author reply 2169-70. 2007
  87. ncbi Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones
    Yanping Guo
    Comprehensive Cancer Center, Division of Hematology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    J Nutr Biochem 18:408-17. 2007
    ..These observations support the hypothesis that genistein may inhibit prostate tumor angiogenesis through the suppression of VEGF-mediated autocrine and paracrine signaling pathways between tumor cells and vascular endothelial cells...
  88. ncbi An improved method for basic hydrolysis of isoflavone malonylglucosides and quality evaluation of Chinese soy materials
    Dan Yuan
    School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China
    Chem Pharm Bull (Tokyo) 56:1-6. 2008
    ....
  89. ncbi Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro
    Tammy E Hedlund
    University of Colorado Health Sciences Center, Department of Pathology, Denver, Colorado 80262, USA
    Prostate 54:68-78. 2003
    ..We hypothesize that equol is a bioactive metabolite that exerts direct antiproliferative effects on prostatic epithelial cells...
  90. ncbi Antioxidant activities of the water-soluble fraction in tempeh-like fermented soybean (GABA-tempeh)
    N Watanabe
    Department of Food Science and Nutrition, Faculty of Human Ecology, Showa Women s University, 1 7 57 Taishido, Setagaya, Tokyo, Japan
    Int J Food Sci Nutr 58:577-87. 2007
    ..The components responsible for the antioxidant activity of GABA-tempeh were isoflavone aglycones, free amino acids, and peptides, which increased during aerobic and anaerobic fermentations...
  91. ncbi Functional components in soybean cake and their effects on antioxidant activity
    Tsai Hua Kao
    Department of Nutrition and Food Sciences, Fu Jen University, Taipei, Taiwan
    J Agric Food Chem 54:7544-55. 2006
    ..Overall, the isoflavone fractions showed a better antioxidant activity than the isoflavone standards, probably caused by the presence of some other functional components such as saponin, flavonoid, and phenolic compounds in soybean cake...
  92. ncbi Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circulation 116:2553-62. 2007
    ..We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI)...
  93. ncbi Intakes and sources of soya foods and isoflavones in a UK population cohort study (EPIC-Norfolk)
    A A Mulligan
    EPIC, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Worts Causeway, Cambridge, UK
    Eur J Clin Nutr 61:248-54. 2007
    ..However, there are little available data on the food sources or distribution of intake in the UK diet...
  94. ncbi Soy product and isoflavone consumption in relation to prostate cancer in Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Tokyo 104 0045 Japan
    Cancer Epidemiol Biomarkers Prev 16:538-45. 2007
    ..52 [95% confidence interval (95% CI), 0.30-0.90], 0.50 (95% CI, 0.28-0.88), and 0.52 (95% CI, 0.29-0.90), respectively. In conclusion, we found that isoflavone intake was associated with a decreased risk of localized prostate cancer...
  95. ncbi Analysis of isoflavone content in tempeh, a fermented soybean, and preparation of a new isoflavone-enriched tempeh
    Nobuyoshi Nakajima
    Graduate School of Health and Welfare Science, Okayama Prefectural University, Kuboki, Soja, Japan
    J Biosci Bioeng 100:685-7. 2005
    ....
  96. ncbi Phytoestrogens: implications in neurovascular research
    Edwin D Lephart
    Department of Physiology and Developmental Biology, Neuroscience Center, 633 WIDB, Brigham Young University, Provo, Utah 84602, USA
    Curr Neurovasc Res 1:455-64. 2004
    ..Because of their diverse health effects and widespread availability in soy foods, dietary phytoestrogens merit continued research into their effects on human health and cognitive function.
  97. ncbi Synthesis of haptens and conjugates for ELISA of glycitein: development and validation of an immunological test
    Svitlana Shinkaruk
    Universite de Bordeaux, EA 2975 UBX1 UBX2 ENITA de Bordeaux, F 33405, France
    J Agric Food Chem 56:6809-17. 2008
    ..This specificity is not influenced by the length of the spacer arm. The assay was validated by measurements performed on plasma samples as well as on soy-based foodstuffs and on soy-based food supplements...
  98. ncbi Antioxidant properties of soybean isoflavone extract and tofu in vitro and in vivo
    Jiabin Liu
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Agric Food Chem 53:2333-40. 2005
    ....
  99. ncbi Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study
    Kotaro Ozasa
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan
    J Epidemiol 15:S196-202. 2005
    ....
  100. ncbi Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay
    Serafim Kiriakidis
    Institute of Pathology, University of Bonn, Bonn, Germany
    Br J Nutr 93:317-23. 2005
    ..Our present findings suggest that the new isoflavones might be added to the list of low molecular mass therapeutic agents for the inhibition of angiogenesis...
  101. ncbi Heating affects the content and distribution profile of isoflavones in steamed black soybeans and black soybean koji
    Ru Yue Huang
    Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 56:8484-9. 2008
    ..9 and 78.8%, respectively, for black soybean koji. In contrast, the heated black soybeans showed an aglycone residual of 68.0%, which is less than the 80.0% noted with the heated black soybean koji...

Research Grants64

  1. MR Dynamic Imaging and Spectroscopy in Head & Neck Cancers
    AMITA DAVE; Fiscal Year: 2010
    ..If successful, it will provide an a priori predictor of failure/response to chemotherapy and/or long term disease free-survival, resulting in patient specific treatment which will likely enhance outcome. ..
  2. Assembly dynamics and cellular function of Actin-like proteins in bacteria
    R Dyche Mullins; Fiscal Year: 2013
    ..The present proposal is aimed at uncovering the mechanism by which AlfA segregates and stabilizes plasmids and determining how the unique properties of AlfA enable it to carry out this task. ..
  3. Gene-Specific Epigenetic Programming of WNT Signaling Pathway by Dietary Soy
    Hong Chen; Fiscal Year: 2009
    ..Dietary factors are closely associated with tumorigenesis and development of colon cancer. Soy foods and soy bioactive components have been linked to lower colon cancer incidence in populations consuming large ..
  4. Molecular targets of soy isoflavones in breast cancer progression
    Suranganie F Dharmawardhane; Fiscal Year: 2011
    ..is SIGNIFICANT to public health by advancing the understanding of the role of natural dietary compounds from soy foods in breast cancer...
  5. Comb External Beam Radiotherapy with 153Sm-EDTMP to Treat High Risk Osteosarcoma
    David M Loeb; Fiscal Year: 2013
    ..In addition, this treatment approach can provide the basis for combining radiopharmaceuticals with external beam radiotherapy for other tumor types as well. ..
  6. PHYTOESTROGENS, ORGANOCHLORINES, AND FIBROID RISK
    Stephen Schwartz; Fiscal Year: 1999
    ..The U.S. population is exposed to dietary sources of phytoestrogens through intake of soy foods, grains, and to a lesser extent fruits and vegetables...
  7. PLANNING A HAWAII/JAPAN MAMMOGRAPHIC DENSITY STUDY
    Gertraud Maskarinec; Fiscal Year: 2000
    ..case-control study exploring the relative importance of mammographic densities and dit, in particular soy foods, as risk factors for breast cancer among women in Japan and women of Japanese and other ancestries living in ..
  8. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..trial, whether a defined dietary intervention of 10 servings/d of fruit and vegetables (cruciferous vegetables, soy foods, and citrus fruits) for 2 weeks affects human lymphocyte DNA damage and resistance to H202-induced damage ..
  9. PRECLINICAL INTERSTITIAL PHOTODYNAMIC THERAPY RESEARCH
    J Chapman; Fiscal Year: 1992
    ....
  10. Soy Isoflavones for Menopausal Vasomotor Symptoms
    Judith Ockene; Fiscal Year: 2006
    ..similar to estrogen and thus bind to estrogen receptors, results from randomized controlled trials of both soy foods and supplements have been mixed...
  11. QUANTITATION & BIOAVAILABILITY OF SOYFOOD ISOFLAVONES
    Patricia Murphy; Fiscal Year: 1992
    This research project plans to examine the amounts of the major soybean isoflavones in soy foods and determine their bioavailability in humans...
  12. Isoflavones, equol producing status, and breast density in US Chinese women
    Carolyn Fang; Fiscal Year: 2009
    Isoflavones, phytoestrogens found primarily in soy foods, are thought to protect against breast cancer, but epidemiologic evidence for such an effect is inconsistent...
  13. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2007
    ..determine whether certain diets, specifically those including regular tea drinking and high intakes of folate, soy foods, allium vegetables, and crucifers, are associated with a reduced risk of cancer...
  14. RADIATION SENSITIZERS--INTERACTIONS
    R Mulcahy; Fiscal Year: 1992
    ..Synthetic efforts will attempt to define specific structural parameters influencing the chemosensitizing, radiosensitizing, and cytotoxic properties of isocyanate-generating nitroheterocyles in vitro and in vivo...
  15. Soy Isoflavone Supplementation and Mammographic Density in Postmenopausal Women
    William Wong; Fiscal Year: 2007
    ..b>Soy foods, which contain high concentrations of isoflavones, might protect against breast cancer, but the potential ..
  16. Effect of Dietary Protein Source on Calcium Metabolism
    Deborah Sellmeyer; Fiscal Year: 2006
    ..Finally, soy protein sources may have a dual benefit: soy foods provide base precursors as well as plant estrogens that may have a beneficial effect on bone...
  17. Breast Density, IGF-I, & Prolactin, in Four Populations
    Gertraud Maskarinec; Fiscal Year: 2004
    ..The statistical analysis will include mixed models to explore the relation between hormone levels and breast density while controlling for confounders and for clustering by study location. ..
  18. Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic Cohort
    Gertraud Maskarinec; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  19. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..Epidemiologic evidence supports a role for soy foods and isoflavones in breast cancer prevention, but the possible mechanisms of action are not well understood...
  20. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
    ..Given the health claims and the growing intake of soy foods and isoflavone supplements among healthy women and breast cancer survivors, it is urgent to investigate the ..
  21. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..Dietary counseling, gift certificates, and soy foods will help to maintain adherence...
  22. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
    ....
  23. Effects of Generational Exposure of Soy Diets on Epigenetic Landscape in Colon Ca
    Hong Chen; Fiscal Year: 2009
    ..Dietary factors are closely associated with tumorigenesis and development of colon cancer. Soy foods and soy bioactive components have been linked to lower colon cancer incidence in populations consuming large ..
  24. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  25. Soy Isoflavone Metabolite Equol--Formation and Fate
    Kenneth Setchell; Fiscal Year: 2008
    ..For unknown reasons only one-third of adults consuming soy foods make equol...
  26. Chemopreventive Actions of Equol Enantiomers
    Kenneth Setchell; Fiscal Year: 2007
    ..These studies are relevant to humans given the ammended health claim for soy and cancer risk-reduction currently being reviewed by the FDA. ..
  27. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  28. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  29. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  30. Effect of Antioxidants on Inflammatory Markers and FMVD
    Christopher Gardner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Phytoestrogens, alcohol, and endometrial cancer risk
    ELISA BANDERA; Fiscal Year: 2007
    ..This award will provide the support and training the Candidate needs to develop an independent career in the nutritional epidemiology of cancer. ..
  32. Comparing Effects of 3 Sources of Garlic on Serum Lipids
    Christopher Gardner; Fiscal Year: 2005
    ..The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids. ..
  33. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  34. Alzheimer's Disease: Potential Benefit of Isoflavones
    Carey Gleason; Fiscal Year: 2008
    ..In addition, blood, collected at each treatment visit, will be assayed for plasma isoflavone levels, and other neuroendocrine markers of interest. [unreadable] [unreadable]..
  35. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    ..Reduction of dietary NaC1 from typical intakes of 200 mmol/day to an intake of 50 mmol/day may decrease the risk of recurrence of calcium-containing kidney stones and slow rates of bone loss, thus reducing risk of osteoporosis as well. ..
  36. Synergy between phytochemicals for prostate cancer prevention
    Jin Rong Zhou; Fiscal Year: 2008
    ..Determinations of cellular biomarkers and identification of candidate molecular markers should provide sufficient preliminary data for further mechanism elucidation in the future RO1 proposal application. ..
  37. ENERGY RESTRICTION, CELL SIGNALING AND CANCER PREVENTION
    Diane Birt; Fiscal Year: 2001
    ..The dependence of the biochemical events modified in Aims 2-4 on corticosterone will be assessed by parallel studies in sham and adrenalectomized mice. ..
  38. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..Studies investigating gene-gene and gene-environment interaction could provide valuable information in identifying high-risk individuals for designing cost-effective preventive strategies for breast cancer. ..
  39. Oldenlandia diffusa for prostate cancer treatment
    Jin Rong Zhou; Fiscal Year: 2008
    ..The cellular markers will be determined in the in vivo samples. [unreadable] [unreadable] [unreadable]..
  40. DIETARY SOYBEAN COMPONENTS AFFECT ON PROSTATE CANCER PRO
    Jin Rong Zhou; Fiscal Year: 2001
    ..It is expencted that the results from proposed project will be translated to future clinical trials on CaP prevention/intervention. ..
  41. CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP
    Gary Fraser; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  42. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
  43. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ....
  44. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  45. LA Health:Primary and Secondary Obesity Prevention
    Donald Williamson; Fiscal Year: 2009
    ..The results of this investigation will significantly impact public health policy related to obesity prevention in rural communities, minority communities, and in children from families that are economically disadvantaged. ..
  46. Wise Mind: Environmental Approach for Obesity Prevention
    Donald Williamson; Fiscal Year: 2004
    ..abstract_text> ..
  47. ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIAL
    Katherine Newton; Fiscal Year: 2004
    ....
  48. Genes Modulated by Soy in Prostate Cancer Progression
    Jin Rong Zhou; Fiscal Year: 2004
    ....
  49. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  50. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  51. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  52. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2006
    ..The apoB-67 mutation may provide insights into mechanisms of low LDL-C and high HDL-C levels and new and better therapies to lower cholesterol. ..
  53. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  54. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  55. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    Diane Birt; Fiscal Year: 2006
    ..This center will serve as a national resource and interact with other institutions...
  56. Mechanisms Linking Dairy to Higher Prostate Cancer Risk
    Marilyn Tseng; Fiscal Year: 2006
    ..Findings will also provide information critical to African Americans, for whom a recommendation to reduce dairy may be harmful rather than beneficial. ..
  57. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  58. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  59. Selenium Isoflavones and Prostate Cancer Risk Reduction
    MERRILL CHRISTENSEN; Fiscal Year: 2004
    ..Discovery of Se- and isoflavone-regulated genes will "identify biomarkers of the consumption of key dietary components, particularly micro- and macronutrients". ..
  60. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..
  61. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  62. Soy Food and Coronary Heart Disease in Women
    Xiao Ou Shu; Fiscal Year: 2008
    ....