cannabis

Summary

Summary: The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.

Top Publications

  1. ncbi Quantitative analysis of cannabinoids from Cannabis sativa using 1H-NMR
    Arno Hazekamp
    Division of Pharmacognosy, Institute of Biology, Leiden University, Einsteinweb 55, 2300 RA Leiden, The Netherlands
    Chem Pharm Bull (Tokyo) 52:718-21. 2004
  2. ncbi Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia
    Matthijs G Bossong
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Prog Neurobiol 92:370-85. 2010
  3. ncbi Cannabis and the brain
    Leslie Iversen
    Department of Pharmacology, University of Oxford, Oxford, UK
    Brain 126:1252-70. 2003
  4. ncbi Neural substrates of faulty decision-making in abstinent marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Neuroimage 26:480-92. 2005
  5. pmc The draft genome and transcriptome of Cannabis sativa
    Harm van Bakel
    Banting and Best Department of Medical Research and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada
    Genome Biol 12:R102. 2011
  6. ncbi Dose related risk of motor vehicle crashes after cannabis use
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, MD 6200 Maastricht, The Netherlands
    Drug Alcohol Depend 73:109-19. 2004
  7. ncbi Proteomic characterization of copper stress response in Cannabis sativa roots
    Elisa Bona
    Department of Environmental and Life Sciences, University of Piemonte Orientale A Avogadro, Alessandria, Italy
    Proteomics 7:1121-30. 2007
  8. ncbi Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Trends Pharmacol Sci 30:515-27. 2009
  9. ncbi Structural MRI findings in long-term cannabis users: what do we know?
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
    Subst Use Misuse 45:1787-808. 2010
  10. pmc Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
    Liam Nestor
    School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 49:1133-43. 2010

Detail Information

Publications297 found, 100 shown here

  1. ncbi Quantitative analysis of cannabinoids from Cannabis sativa using 1H-NMR
    Arno Hazekamp
    Division of Pharmacognosy, Institute of Biology, Leiden University, Einsteinweb 55, 2300 RA Leiden, The Netherlands
    Chem Pharm Bull (Tokyo) 52:718-21. 2004
    ..method has been developed for the quantitative analysis of pure cannabinoids and for cannabinoids present in Cannabis sativa plant material without any chromatographic purification...
  2. ncbi Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia
    Matthijs G Bossong
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Prog Neurobiol 92:370-85. 2010
    b>Cannabis use during adolescence increases the risk of developing psychotic disorders later in life. However, the neurobiological processes underlying this relationship are unknown...
  3. ncbi Cannabis and the brain
    Leslie Iversen
    Department of Pharmacology, University of Oxford, Oxford, UK
    Brain 126:1252-70. 2003
    The active compound in herbal cannabis, Delta(9)-tetrahydrocannabinol, exerts all of its known central effects through the CB(1) cannabinoid receptor...
  4. ncbi Neural substrates of faulty decision-making in abstinent marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Neuroimage 26:480-92. 2005
    ..Finally, it is unclear if these neurologic findings will become progressively worse with continued heavy MJ use or if they will resolve with abstinence from MJ use...
  5. pmc The draft genome and transcriptome of Cannabis sativa
    Harm van Bakel
    Banting and Best Department of Medical Research and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada
    Genome Biol 12:R102. 2011
    b>Cannabis sativa has been cultivated throughout human history as a source of fiber, oil and food, and for its medicinal and intoxicating properties...
  6. ncbi Dose related risk of motor vehicle crashes after cannabis use
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, MD 6200 Maastricht, The Netherlands
    Drug Alcohol Depend 73:109-19. 2004
    ..confirmed experimental data, but culpability surveys showed little evidence that crashed drivers who only used cannabis are more likely to cause accidents than drug free drivers...
  7. ncbi Proteomic characterization of copper stress response in Cannabis sativa roots
    Elisa Bona
    Department of Environmental and Life Sciences, University of Piemonte Orientale A Avogadro, Alessandria, Italy
    Proteomics 7:1121-30. 2007
    b>Cannabis sativa is an annual herb with very high biomass and capability to absorb and accumulate heavy metals in roots and shoots; it is therefore a good candidate for phytoremediation of soils contaminated with metals...
  8. ncbi Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Trends Pharmacol Sci 30:515-27. 2009
    ..However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than ..
  9. ncbi Structural MRI findings in long-term cannabis users: what do we know?
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia
    Subst Use Misuse 45:1787-808. 2010
    ..g., hippocampus, cerebral cortex). While cannabis remains the most widely used illicit drug worldwide, there has been limited work investigating its effects on ..
  10. pmc Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
    Liam Nestor
    School of Psychology and Institute of Neuroscience, Trinity College Dublin, Ireland
    Neuroimage 49:1133-43. 2010
    Despite an increased understanding of the pharmacology and long-term cognitive effects of cannabis in humans, there has been no research to date examining its chronic effects upon reward processing in the brain...
  11. ncbi Cannabis use in young people: the risk for schizophrenia
    Paola Casadio
    Mental Health Department, AUSL Ravenna, Via Baliatico 3, Faenza RA, Italy
    Neurosci Biobehav Rev 35:1779-87. 2011
    b>Cannabis is one of the most commonly used illicit drugs, and despite the widely held belief that it is a safe drug, its long-term use has potentially harmful consequences...
  12. ncbi Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    Zlatko Mehmedic
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Forensic Sci 55:1209-17. 2010
    ..with the National Institute on Drug Abuse (NIDA) to carry out a variety of research activities dealing with cannabis, including the Potency Monitoring (PM) program, which provides analytical potency data on cannabis preparations ..
  13. ncbi Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers
    Mark Wallace
    Department of Anesthesiology, University of California, San Diego, USA
    Anesthesiology 107:785-96. 2007
    ..Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin.
  14. ncbi Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics
    D Arnone
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuroimage 41:1067-74. 2008
    ..Structural abnormalities revealed in the CC may underlie cognitive and behavioural consequences of long term heavy marijuana use...
  15. ncbi Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial
    D I Abrams
    Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
    Neurology 68:515-21. 2007
    To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model.
  16. ncbi Lower Risk Cannabis use Guidelines for Canada (LRCUG): a narrative review of evidence and recommendations
    Benedikt Fischer
    Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, BC
    Can J Public Health 102:324-7. 2011
    More than one in ten adults--and about one in three young adults--report past year cannabis use in Canada...
  17. pmc Early cannabis use and estimated risk of later onset of depression spells: Epidemiologic evidence from the population-based World Health Organization World Mental Health Survey Initiative
    Ron de Graaf
    Department of Epidemiology, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Am J Epidemiol 172:149-59. 2010
    Early-onset cannabis use is widespread in many countries and might cause later onset of depression. Sound epidemiologic data across countries are missing...
  18. pmc Approach-bias predicts development of cannabis problem severity in heavy cannabis users: results from a prospective FMRI study
    Janna Cousijn
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e42394. 2012
    ..Here we investigated the neural underpinnings of cannabis approach and avoidance tendencies...
  19. ncbi Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
    ..volume reductions are progressive in schizophrenia, with larger grey matter volume decreases associated with cannabis use...
  20. ncbi Long-term effects of frequent cannabis use on working memory and attention: an fMRI study
    Gerry Jager
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychopharmacology (Berl) 185:358-68. 2006
    Excessive use of cannabis may have long-term effects on cognitive abilities. Mild impairments have been found in several cognitive domains, particularly in memory and attention...
  21. pmc Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Catalina Lopez-Quintero
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Drug Alcohol Depend 115:120-30. 2011
    This study aims to estimate general and racial-ethnic specific cumulative probability of developing dependence among nicotine, alcohol, cannabis or cocaine users, and to identify predictors of transition to substance dependence.
  22. ncbi Impact of cannabis use on brain function in adolescents
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Ann N Y Acad Sci 1021:384-90. 2004
    b>Cannabis is the most common illicit substance used by adolescents...
  23. pmc Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, CNR, Pozzuoli NA, Italy
    Br J Pharmacol 163:1479-94. 2011
    ..Cannabidiol (CBD) and Δ(9) -tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system...
  24. ncbi The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  25. ncbi Cannabis and the developing brain: insights from behavior
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Pharmacol 585:441-52. 2008
    ..and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, opened the door to a whole new field of medical research...
  26. ncbi Prenatal marijuana exposure: effect on child depressive symptoms at ten years of age
    Kimberly A Gray
    Susceptibility and Population Health Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Neurotoxicol Teratol 27:439-48. 2005
    ..These findings are consistent with recent reports that identify specific areas of the brain and specific brain functions that are associated with PME...
  27. ncbi Role of cannabis and endocannabinoids in the genesis of schizophrenia
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain
    Psychopharmacology (Berl) 206:531-49. 2009
    b>Cannabis abuse and endocannabinoids are associated to schizophrenia.
  28. ncbi Effects of prenatal marijuana on visuospatial working memory: an fMRI study in young adults
    Andra M Smith
    Department of Psychology, University of Ottawa, Ottawa, Ontario, Canada, K1N 6N5
    Neurotoxicol Teratol 28:286-95. 2006
    ..There was also significantly less activity in right inferior and middle frontal gyri. These results suggest that prenatal marijuana exposure alters neural functioning during visuospatial working memory processing in young adulthood...
  29. ncbi Adverse health effects of non-medical cannabis use
    Wayne Hall
    School of Population Health, University of Queensland, Herston, QLD, Australia
    Lancet 374:1383-91. 2009
    For over two decades, cannabis, commonly known as marijuana, has been the most widely used illicit drug by young people in high-income countries, and has recently become popular on a global scale...
  30. pmc Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys
    Louisa Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Med 5:e141. 2008
    ..This paper describes such data from the first 17 countries participating in the World Health Organization's (WHO's) World Mental Health (WMH) Survey Initiative...
  31. ncbi Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, Box P067, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:442-51. 2009
    b>Cannabis sativa use can impair verbal learning, provoke acute psychosis, and increase the risk of schizophrenia. It is unclear where C. sativa acts in the human brain to modulate verbal learning and to induce psychotic symptoms.
  32. ncbi Drugs and driving
    J Michael Walsh
    The Walsh Group, P A, Bethesda, Maryland, USA
    Traffic Inj Prev 5:241-53. 2004
    ....
  33. ncbi Age of onset of cannabis use is associated with age of onset of high-risk symptoms for psychosis
    Sara Dragt
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Can J Psychiatry 55:165-71. 2010
    ..We hypothesized that cannabis use or a cannabis use disorder at a younger age relates to high-risk symptoms at a younger age.
  34. pmc A within-subject comparison of withdrawal symptoms during abstinence from cannabis, tobacco, and both substances
    R G Vandrey
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 92:48-54. 2008
    A cannabis withdrawal syndrome has been characterized, but its clinical significance remains uncertain. One method of assessing the significance of cannabis withdrawal is to compare it directly to an established withdrawal syndrome...
  35. ncbi Cannabis, cannabinoids and reproduction
    Boram Park
    Department of Pharmacology and Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prostaglandins Leukot Essent Fatty Acids 70:189-97. 2004
    In most countries Cannabis is the most widely used illegal drug. Its use during pregnancy in developed nations is estimated to be approximately 10%...
  36. ncbi Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines
    Rebecca Kuepper
    Department of Psychiatry and Psychology, EURON, Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands
    Schizophr Res 121:107-17. 2010
    General population epidemiological studies have consistently found that cannabis use increases the risk of developing psychotic disorders in a dose-dependent manner...
  37. ncbi The time course and significance of cannabis withdrawal
    Alan J Budney
    Department of Psychiatry, University of Vermont, South Burlington 05403, USA
    J Abnorm Psychol 112:393-402. 2003
    Withdrawal symptoms following cessation of heavy cannabis (marijuana) use have been reported, yet their time course and clinical importance have not been established...
  38. ncbi The marijuana withdrawal syndrome: diagnosis and treatment
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Curr Psychiatry Rep 7:360-6. 2005
    A subset of marijuana smokers develop a cannabis use disorder and seek treatment for their marijuana use on their own initiative...
  39. ncbi The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?
    Lynn E DeLisi
    New York University, New York, NY 10016, USA
    Curr Opin Psychiatry 21:140-50. 2008
    This review explores what is known about the association of cannabis with schizophrenia, its effects on the brain, and whether the brain changes known to be present in schizophrenia could be caused by cannabis and thus lead to a psychosis.
  40. ncbi Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study
    C B Carroll
    Department of Neurology, Derriford Hospital, Plymouth, UK
    Neurology 63:1245-50. 2004
    ..The authors conducted a randomized, double-blind, placebo-controlled crossover trial to examine the hypothesis that cannabis may have a beneficial effect on dyskinesia in PD.
  41. ncbi Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: an in vivo SPECT study
    Gemma Safont
    Department of Psychiatry, Hospital Universitari Mutua Terrassa, Universitat de Barcelona UB, Plaça Dr Robert, 5 08221, Terrassa, Barcelona, Spain
    Schizophr Res 129:169-71. 2011
    The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood...
  42. pmc Phytocannabinoids beyond the Cannabis plant - do they exist?
    Jürg Gertsch
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Br J Pharmacol 160:523-9. 2010
    ..b>Cannabis sativa L...
  43. ncbi [Cognitive abnormalities and cannabis use]
    Nadia Solowij
    School of Psychology, University of Wollongong, Wollongong, Australia
    Rev Bras Psiquiatr 32:S31-40. 2010
    Evidence that cannabis use impairs cognitive function in humans has been accumulating in recent decades. The purpose of this overview is to update knowledge in this area with new findings from the most recent literature.
  44. ncbi Moral regulation and the presumption of guilt in Health Canada's medical cannabis policy and practice
    Philippe Lucas
    Studies in Policy and Practice, Faculty of Human and Social Development, University of Victoria, PO Box 1700, STN CSC, 3800 Finnerty Road, Victoria, BC, V8W 2Y2 Canada
    Int J Drug Policy 20:296-303. 2009
    ..Marihuana Medical Access Division (MMAD) that presume the illicit intentions and inherent "guilt" of medical cannabis users, hampering safe access to a medicine to which many are legally entitled, and raising doubts about this ..
  45. ncbi Lack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteers
    Birgit Kraft
    Department of Anesthesiology and Intensive Care Medicine A, Medical University of Vienna, Vienna, Austria
    Anesthesiology 109:101-10. 2008
    ..Therefore, the aim of this study was to investigate the effects of oral cannabis extract in two different human models of acute inflammatory pain and hyperalgesia.
  46. pmc Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
    Ethan B Russo
    GW Pharmaceuticals, Salisbury, Wiltshire, UK
    Br J Pharmacol 163:1344-64. 2011
    Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it...
  47. ncbi The role of cannabis in cognitive functioning of patients with schizophrenia
    Thomas Schnell
    Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Psychopharmacology (Berl) 205:45-52. 2009
    Cognitive deficits are commonly found both in patients with schizophrenia (SCH) and in people with cannabis use disorders (CUD)...
  48. ncbi Cannabis use disorder: epidemiology and management
    Jan Copeland
    National Cannabis Prevention and Information Centre, University of New South Wales, Sydney, New South Wales, Australia
    Int Rev Psychiatry 21:96-103. 2009
    This paper provides an overview of the epidemiology of cannabis use, cannabis use disorders and its treatment. Cannabis is the most commonly used illicit drug internationally...
  49. pmc Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis
    Mark Asbridge
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1V7
    BMJ 344:e536. 2012
    To determine whether the acute consumption of cannabis (cannabinoids) by drivers increases the risk of a motor vehicle collision.
  50. ncbi Cannabis, the mind and society: the hash realities
    Robin M Murray
    Institute of Psychiatry, Psychological Medicine, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Nat Rev Neurosci 8:885-95. 2007
    b>Cannabis has been known for at least 4,000 years to have profound effects on the mind--effects that have provoked dramatically divergent attitudes towards it...
  51. ncbi The Cannabis Withdrawal Scale development: patterns and predictors of cannabis withdrawal and distress
    David J Allsop
    National Cannabis Prevention and Information Centre, University of New South Wales, Sydney 2031, Australia
    Drug Alcohol Depend 119:123-9. 2011
    Rates of treatment seeking for cannabis are increasing, and relapse is common. Management of cannabis withdrawal is an important intervention point...
  52. pmc Cannabis withdrawal in adolescent treatment seekers
    Ryan Vandrey
    Department of Psychology and Psychiatry, University of Vermont, 54 W Twin Oaks Terrace, Suite 12, S Burlington, VT 05403, USA
    Drug Alcohol Depend 78:205-10. 2005
    A valid cannabis withdrawal syndrome has been demonstrated in controlled studies with adult marijuana abusers, yet few published reports have examined cannabis withdrawal among adolescents...
  53. ncbi The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes
    Jake M Stout
    Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, SK, S7N 0W9 Canada
    Plant J 71:353-65. 2012
    The psychoactive and analgesic cannabinoids (e.g. Δ(9) -tetrahydrocannabinol (THC)) in Cannabis sativa are formed from the short-chain fatty acyl-coenzyme A (CoA) precursor hexanoyl-CoA...
  54. pmc Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers
    Kenneth H Levin
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:120-7. 2010
    b>Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance.
  55. ncbi A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder: a double-blind randomized controlled trial
    M Berk
    Department of Psychiatry, University of the Witwatersrand Medical School, Parktown, South Africa
    Int Clin Psychopharmacol 14:177-80. 1999
    ..In this study, 30 patients meeting DSM-IV criteria for cannabis induced psychotic disorder were randomly allocated to receive either olanzapine or haloperidol in a 4-week double-..
  56. ncbi The mediation role of licit drugs in the influence of socializing on cannabis use among adolescents: A quantitative approach
    Aurélie Mayet
    INSERM U, Paris Sud Innovation Group in Adolescent Mental Health, Maison de Solenn, Paris, France
    Addict Behav 35:890-5. 2010
    Licit substance use could be an early stage leading on to cannabis use. The aim of the study was to test a hypothetical sequential process leading from socializing to cannabis use so as to evaluate the mediator role of tobacco and alcohol...
  57. ncbi Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patients
    Valérie Wolff
    Unite Neuro Vasculaire, Hopitaux Universitaires de Strasbourg, France
    Stroke 42:1778-80. 2011
    Our objective was to evaluate the relationship between cannabis use and ischemic stroke in a young adult population.
  58. ncbi Cannabis and its derivatives: review of medical use
    Lawrence Leung
    Department of Family Medicine, Queen s University, Kingston ON K7L 5E9, Canada
    J Am Board Fam Med 24:452-62. 2011
    Use of cannabis is often an under-reported activity in our society...
  59. pmc Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life
    Jimena Fiz
    Human Pharmacology and Neurosciences Unit, Institut de Recerca Hospital del Mar IMIM, Parc de Salut Mar, Barcelona, Spain
    PLoS ONE 6:e18440. 2011
    The aim of this study was to describe the patterns of cannabis use and the associated benefits reported by patients with fibromyalgia (FM) who were consumers of this drug...
  60. pmc Cannabis and psychosis/schizophrenia: human studies
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, Psychiatry Service, VA Connecticut Healthcare System, 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Eur Arch Psychiatry Clin Neurosci 259:413-31. 2009
    The association between cannabis use and psychosis has long been recognized. Recent advances in knowledge about cannabinoid receptor function have renewed interest in this association...
  61. ncbi Self-control and its relation to joint developmental trajectories of cannabis use and depressive mood symptoms
    Roy Otten
    Behavioural Science Institute, Radboud University, P O Box 9104, 6500 HE Nijmegen, The Netherlands
    Drug Alcohol Depend 112:201-8. 2010
    b>Cannabis use and depressive mood symptoms in adolescence have been found to co-occur...
  62. ncbi Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
    Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD).
  63. ncbi Cannabis and anxiety: a critical review of the evidence
    José Alexandre Crippa
    Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirao Preto School of Medicine, University of São Paulo USP RP and INCT Translational Medicine, Brazil
    Hum Psychopharmacol 24:515-23. 2009
    Anxiety reactions and panic attacks are the acute symptoms most frequently associated with cannabis use...
  64. pmc The effect of cannabis compared with alcohol on driving
    R Andrew Sewell
    VA Connecticut Healthcare Yale University School of Medicine, West Haven, Connecticut, USA
    Am J Addict 18:185-93. 2009
    The prevalence of both alcohol and cannabis use and the high morbidity associated with motor vehicle crashes has lead to a plethora of research on the link between the two...
  65. pmc Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents
    Patrizia Campolongo
    Department of Physiology and Pharmacology, Sapienza University of Rome, P le A Moro 5, 00185, Rome, Italy
    Psychopharmacology (Berl) 214:5-15. 2011
    b>Cannabis is the most commonly used illicit drug among pregnant women...
  66. ncbi History of cannabis and its preparations in saga, science, and sobriquet
    Ethan B Russo
    Chem Biodivers 4:1614-48. 2007
    b>Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a source of controversy throughout its history...
  67. ncbi Comparative effects of alcohol and marijuana on mood, memory, and performance
    S J Heishman
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 58:93-101. 1997
    ..These data are useful for understanding the relative performance impairment produced by alcohol and marijuana at the delivered doses and the relationship between their subjective and behavioral effects...
  68. ncbi Cannabis with high δ9-THC contents affects perception and visual selective attention acutely: an event-related potential study
    K B E Böcker
    Dept Psychopharmacology, Utrecht Institute of Pharmaceutical Studies and Rudolf Magnus Institute of Neuroscience, Utrecht University, The Netherlands
    Pharmacol Biochem Behav 96:67-74. 2010
    b>Cannabis intake has been reported to affect cognitive functions such as selective attention. This study addressed the effects of exposure to cannabis with up to 69...
  69. pmc Phytochemical and genetic analyses of ancient cannabis from Central Asia
    Ethan B Russo
    Institute of Botany, Chinese Academy of Sciences
    J Exp Bot 59:4171-82. 2008
    ..excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions...
  70. ncbi Adverse effects of cannabis on health: an update of the literature since 1996
    Harold Kalant
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, ON, Canada M5S 1A8
    Prog Neuropsychopharmacol Biol Psychiatry 28:849-63. 2004
    Recent research has clarified a number of important questions concerning adverse effects of cannabis on health...
  71. ncbi Psychophysiological responses to drug-associated stimuli in chronic heavy cannabis use
    Klaus Wolfling
    Medical Psychology and Medical Sociology, Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Mainz, Saarstr 21, 55099 Mainz, Germany
    Eur J Neurosci 27:976-83. 2008
    ..The goal of the present study was the analysis of changes in cortical and peripheral reactivity to cannabis as well as alcohol-associated pictures compared with emotionally significant drug-unrelated and neutral pictures ..
  72. ncbi Prenatal marijuana and alcohol exposure and academic achievement at age 10
    Lidush Goldschmidt
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurotoxicol Teratol 26:521-32. 2004
    ..Second-trimester binge drinking predicted lower reading scores. There was no interaction between prenatal marijuana and alcohol exposure. Each was an independent predictor of academic performance...
  73. ncbi The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Eur J Pharmacol 556:75-83. 2007
    Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-inflammatory and immunomodulatory effects...
  74. ncbi NMR assignments of the major cannabinoids and cannabiflavonoids isolated from flowers of Cannabis sativa
    Young Hae Choi
    Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Phytochem Anal 15:345-54. 2004
    The complete 1H- and 13C-NMR assignments of the major Cannabis constituents, delta9-tetrahydrocannabinol, tetrahydrocannabinolic acid, delta8-tetrahydrocannabinol, cannabigerol, cannabinol, cannabidiol, cannabidiolic acid, cannflavin A ..
  75. ncbi The emerging functions of endocannabinoid signaling during CNS development
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
    Trends Pharmacol Sci 28:83-92. 2007
    ..the molecular basis of permanent modifications to cellular structure and intercellular communication imposed by cannabis smoking during pregnancy will provide novel therapeutic targets for alleviating pathogenic changes in affected ..
  76. ncbi Cannabis and brain morphology in recent-onset schizophrenia
    W Cahn
    Schizophr Res 67:305-7. 2004
  77. ncbi Causal association between cannabis and psychosis: examination of the evidence
    Louise Arseneault
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 184:110-7. 2004
    Controversy remains as to whether cannabis acts as a causal risk factor for schizophrenia or other functional psychotic illnesses.
  78. ncbi Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neurochem 89:134-41. 2004
    ..Here, we studied the effect of cannabidiol, a major non-psychoactive component of the marijuana plant (Cannabis sativa) on beta-amyloid peptide-induced toxicity in cultured rat pheocromocytoma PC12 cells...
  79. ncbi Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteers
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Eur Neuropsychopharmacol 18:569-77. 2008
    ..Delta9-Tetrahydrocannabinol (Delta9-THC), the main active constituent of Cannabis sativa, has been known to acutely impair cognitive abilities in several domains, particularly in memory and ..
  80. ncbi Plant, synthetic, and endogenous cannabinoids in medicine
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institutes of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Annu Rev Med 57:553-74. 2006
    Although used for more than 4000 years for recreational and medicinal purposes, Cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently...
  81. ncbi Coma due to cannabis toxicity in an infant
    Andrew Appelboam
    Department of Emergency Medicine, Royal Devon and Exeter Hospital, Exeter, Devon, UK
    Eur J Emerg Med 13:177-9. 2006
    In young children, cannabis ingestion resulting in coma is very rare. Only nine cases have been reported in the literature and most have occurred in inquisitive toddlers...
  82. pmc Brief intervention addressing excessive cannabis use in young people consulting their GP: a pilot study
    Dagmar M Haller
    Department of Community Medicine and Primary Care, Geneva University Hospitals and University of Geneva, Switzerland
    Br J Gen Pract 59:166-72. 2009
    When excessive cannabis consumption occurs in adolescence, the adverse consequences extend into adulthood. Interventions by GPs are effective in preventing harm associated with alcohol use...
  83. ncbi Therapeutic potential of cannabis in pain medicine
    R D Hosking
    Neurology Research Group, Peninsula Medical School, Plymouth, UK
    Br J Anaesth 101:59-68. 2008
    Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance...
  84. ncbi Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study
    Igor Grant
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:679-89. 2003
    ..We provide a quantitative synthesis of empirical research pertaining to the non-acute (residual) effects of cannabis on the neurocognitive performance of adult human subjects...
  85. ncbi Barriers to access to medical cannabis for Canadians living with HIV/AIDS
    L Belle-Isle
    Canadian AIDS Society, Otawa, Ontario
    AIDS Care 19:500-6. 2007
    North American studies suggest that as many as one-third of people living with HIV/AIDS self-medicate with cannabis for relief of physical and stress-related symptoms...
  86. ncbi Long lasting consequences of cannabis exposure in adolescence
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, Busto Arsizio VA, Italy
    Mol Cell Endocrinol 286:S108-13. 2008
    Despite the increasing use of cannabis among adolescents, there are little and often contradictory studies on the long-term neurobiological consequences of cannabis consumption in juveniles...
  87. ncbi Generalized pruritus in a patient sensitized to tobacco and cannabis
    Simone Schwarzenbach Stöckli
    Division of Allergy, Department of Dermatology, University Hospital of Basel, Switzerland
    J Dtsch Dermatol Ges 5:303-4. 2007
    ..Similar respiratory problems and anaphylactoid reactions have been observed in patients sensitized to cannabis. This may occur in those allergic to cannabis pollen when the plants bloom, in those with agricultural exposure ..
  88. ncbi A qualitative and quantitative HPTLC densitometry method for the analysis of cannabinoids in Cannabis sativa L
    Justin T Fischedick
    Division of Pharmacognosy, Institute of Biology, Leiden University, Leiden, The Netherlands
    Phytochem Anal 20:421-6. 2009
    b>Cannabis and cannabinoid based medicines are currently under serious investigation for legitimate development as medicinal agents, necessitating new low-cost, high-throughput analytical methods for quality control.
  89. ncbi Who is using cannabis as a medicine and why: an exploratory study
    A C Ogborne
    Centre for Addiction and Mental Health, London, Ontario, Canada
    J Psychoactive Drugs 32:435-43. 2000
    This article reports on an exploratory study of medical cannabis users. Interviews were completed with 50 self-identified medical cannabis users recruited through notices in newspapers and on bulletin boards...
  90. pmc Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
    Shaheen E Lakhan
    Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
    BMC Neurol 9:59. 2009
    b>Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes...
  91. ncbi The prevalence and significance of cannabis use in patients prescribed chronic opioid therapy: a review of the extant literature
    Gary M Reisfield
    Division of Addiction Medicine, Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida, USA
    Pain Med 10:1434-41. 2009
    b>Cannabis is the most widely consumed illicit drug in the United States. Its use, particularly in early initiates, is associated with subsequent development of other drug and alcohol use disorders.
  92. ncbi Modulation of the effects of alcohol on driving-related psychomotor skills by chronic exposure to cannabis
    A Wright
    School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Psychopharmacology (Berl) 160:213-9. 2002
    Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters ..
  93. ncbi Cannabis Sativa: getting closer to separating the medicinal properties from the drug of abuse
    Nephi Stella
    J Neuroimmunol 166:1-2. 2005
  94. ncbi Alcohol and cannabis use in schizophrenia: effects of clozapine vs. risperidone
    Alan I Green
    Commonwealth Research Center, Boston, MA, USA
    Schizophr Res 60:81-5. 2003
    Alcohol and cannabis use disorders worsen the course of schizophrenia...
  95. ncbi Cannabis use in adolescents: the impact of risk and protective factors and social functioning
    David Best
    National Addiction Centre Institute of Psychiatry, London, UK
    Drug Alcohol Rev 24:483-8. 2005
    The study uses a school-based sample to test the social and familial risk and protective factors relating to cannabis use...
  96. ncbi Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits
    Paul C Fletcher
    Box 189, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Trends Cogn Sci 10:167-74. 2006
    ..In this respect, ketamine and tetrahydrocannabinol (cannabis) are coming under increasing scrutiny as models for schizophrenia...
  97. ncbi Assessment of cannabis craving using the Marijuana Craving Questionnaire
    Stephen J Heishman
    Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Med 123:209-16. 2006
    b>Cannabis is the most widely used illicit drug in the United States, with 14.6 million current users...
  98. ncbi Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    Barbara Costa
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 369:294-9. 2004
    ..The effect on NO seemed to depend on a lower expression of the endothelial isoform of NO synthase. In conclusion, oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia...
  99. pmc Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia
    Wei Xiong
    Laboratory for Integrative Neuroscience, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 7:296-303. 2011
    ..These findings reveal a new mechanism underlying cannabinoid potentiation of GlyRs, which could contribute to some of the cannabis-induced analgesic and therapeutic effects.
  100. pmc Biomarkers for the effects of cannabis and THC in healthy volunteers
    Lineke Zuurman
    Centre for Human Drug Research, Leiden, The Netherlands
    Br J Clin Pharmacol 67:5-21. 2009
    ..This systemic literature review aims to assess the usefulness of direct biomarkers for the effects of cannabis and tetrahydrocannabinol (THC) in healthy volunteers...
  101. ncbi Different psychological effects of cannabis use in adolescents at genetic high risk for schizophrenia and with attention deficit/hyperactivity disorder (ADHD)
    Chris Hollis
    Developmental Psychiatry, University of Nottingham, E Floor, South Block, Queens Medical Centre, Derby Road, Nottingham, England NG7 2UH, UK
    Schizophr Res 105:216-23. 2008
    Controversy exists regarding whether young people at risk for schizophrenia are at increased risk of adverse mental effects of cannabis use.

Research Grants78

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..It has been known for thousands of years that cannabis extracts increase appetite, particularly for highly palatable foods and can result in weight gain...
  2. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Marijuana (cannabis) and other abused drugs produce their rewarding effects through the regulation biochemical signaling pathways in ..
  3. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    b>Cannabis sativa is currently the most commonly-used, illicit drug in the United States. Cannabis use, particularly by adolescents, increases the risk of developing schizophrenia-like psychoses in later life...
  4. Multigenerational Epigenetic Effects of Cannabis Exposure
    Yasmin L Hurd; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Marijuana (Cannabis sativa) is the most commonly abused illicit drug by teens and young adults of childbearing age in the USA with significant social and public health implications...
  5. Prenatal Cannabis Exposure and Epigenetic Mechanisms Underlying Vulnerability to
    CLAUDIA VARGAS MORRIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): An increasing number of states are legalizing marijuana (Cannabis sativa), yet the neurobiological consequences are largely unknown...
  6. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    Delta-9-Tetrahydrocannabinol (THC), the active ingredient in the cannabis plant, has a wide range of pharmacological properties of therapeutic value...
  7. Drug tourism to Mexico: Impact of Mexicos new drug law on HIV-HCV-TB in US IDUs
    Richard S Garfein; Fiscal Year: 2013
    ..decriminalizing possession of personal-sized quantities of drugs including heroin, cocaine, methamphetamine and cannabis. The sister-cities of San Diego, CA, USA and Tijuana, BC, Mexico share the world's busiest land border ..
  8. Intimate partner violence in newly married couples: The role of illicit drug use.
    Philip H Smith; Fiscal Year: 2012
    ..Experimental evidence that the psychopharmacological effects of different illicit drug types (i.e. cannabis, cocaine) elicit aggressive behavior is equivocal, suggesting that it is important to research more distal ..
  9. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Ronald F Tuma; Fiscal Year: 2012
    ..O-1966 is a member of the cannabinoid class of molecules. While cannabinoids derived from the plant Cannabis Sativa have been used for thousands of years, their value in the treatment of diseases such as MS has been ..
  10. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Worldwide, stimulants such as methamphetamine rank second only to cannabis in number of users, and in North America, the prevalence of amphetamine abuse is double the global rate...
  11. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ..D9-tetrahydrocannabinol (THC), the primary psychoactive constituent in Cannabis sativa, has long been known to reduce naloxone- precipitated withdrawal symptoms in opioid-dependent animals...
  12. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Derivatives of Cannabis sativa (cannabinoids) are potent analgesics, and endogenous cannabinoids share this property...
  13. Neurodevelopmental Effects of Cannabis and its Epigenetic Regulation
    Yasmin L Hurd; Fiscal Year: 2013
    ..Marijuana (Cannabis sativa) is the illicit drug most commonly used by pregnant women and teenagers...
  14. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..trigger relapses and negatively impact the course of illness in schizophrenia patients, and 3) exposure to cannabis may contribute to the risk of developing schizophrenia...
  15. Synaptic plasticity in adolescent cannabis users: relevance to schizophrenia
    Subroto Ghose; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cannabis is the most commonly abused illicit drug in the United States. Daily marijuana use is now at a 30-year peak level among high school seniors...
  16. First-Episode Psychosis and Pre-Onset Cannabis Use
    Michael T Compton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cannabis use in adolescence and young adulthood is very common in the United States...
  17. Cannabinoid Receptor Interacting Protein1a Structure-Function
    LAWRENCE CHRISTOPHER BLUME; Fiscal Year: 2013
    ..Allyn C. Howlett in the Department of Physiology and Pharmacology at Wake Forest University Health Sciences. Cannabis is currently the most widely used illicit drug in the United Sates, and produces its psychotropic effects ..
  18. Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    Kalpna Gupta; Fiscal Year: 2013
    ..A proof of principl study in humans will be undertaken to examine the effect of Cannabis ion pain in sickle patients...
  19. Marijuana use, problems, and cannabis use disorders in OIF/OEF/OND veterans
    Jane Metrik; Fiscal Year: 2013
    ..course of marijuana use and associated problems and there are no prospective studies on the comorbidity of cannabis use and affective disorders among veterans following deployment...
  20. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2013
    ..Moreover, HIV and cancer patients are well known users of cannabis for stimulating appetite to alleviate the wasting syndrome that accompanies AIDS and as an antiemetic to relieve ..
  21. Mechanistic studies of 2-AG inactivation inhibitors as antidepressants
    Qing Song Liu; Fiscal Year: 2013
    ..increases the incidence of anxiety and depression in clinical trials for the treatment of obesity, whereas cannabis improves mood in humans and CB1 agonists produce antidepressant-like effects in animal models of depression...
  22. Cannabinoids Control Breast Cancer Progression Through Id-1
    Sean D McAllister; Fiscal Year: 2012
    ..We recently showed that CBD, a non-psychoactive cannabinoid compound derived from cannabis, could represent the first non-toxic exogenous agent that can down-regulate Id-1 expression...
  23. Behavioral Economic Analysis of Medical Marijuana Use in HIV+ Patients
    Mark K Greenwald; Fiscal Year: 2013
    ..These findings will be disseminated to patients, providers and society to promote public health and informed policy debate. ..
  24. Transdermal Cannabinoid Prodrug Treatment for Cannabis Withdrawal and Dependence
    Lynn Webster; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cannabis use disorders affect approximately 1...
  25. The Effects of Sleep Deprivation on Drug Craving and Cue-Reactivity
    George H Trksak; Fiscal Year: 2012
    ....
  26. TRANSLATIONAL CTR ON THE CLINICAL NEUROBIOL OF CANNABIS ADDICTION
    Barbara J Mason; Fiscal Year: 2010
    ..goal of this P20 application is to develop a translational research center for the study of the neurobiology of cannabis dependence...
  27. IND-enabling Studies and GMP Scale-up of 18-Methoxycoronaridine hydrochloride(18-
    Scott Freeman; Fiscal Year: 2013
    ..Also, there are no medications approved for cocaine, methamphetamine or cannabis use disorders...
  28. The neuronal basis of cannabis-induced developmental deficits in the CNS
    Yasmin L Hurd; Fiscal Year: 2012
    ..receptors are the preferred cellular targets of 9-tetrahydrocannabinol (THC), the active component from cannabis, and cannabis smoking during pregnancy causes life-long motor and cognitive deficits, controlled centrally by ..
  29. Endocannabinoid system and inhibition in bipolar disorder
    William Perry; Fiscal Year: 2013
    ..Further, despite prevalent cannabis use in BD, the function of the EC system has also not been examined in this disorder...
  30. A Role for Endocannabinoids in the Control of Dietary Fat Intake
    NICHOLAS VINCENT DIPATRIZIO; Fiscal Year: 2013
    ..eCBs are endogenous lipids that bind to and activate the same receptors as 9-THC, the psychoactive component in cannabis. Recent data from our laboratory indicate that oral exposure to dietary fat stimulates eCB mobilization in the ..
  31. CANNABINOID RECEPTORS IN NEURONAL CELLS AND BRAIN
    Allyn C Howlett; Fiscal Year: 2013
    ..Development of legitimate CB1 medicines can dispel myths associated with the notion of "medical marihuana". ..
  32. Cannabinergic Ligands and Drugs
    Alexandros Makriyannis; Fiscal Year: 2012
    ..The long-term goals of this application are to develop: (a) novel therapeutic medications for the treatment of cannabis, nicotine and stimulant abuse and (b) novel non-opioid analgesics devoid of undesirable side effects.
  33. Development of Novel Medication Strategies for Opiate Abuse
    Yasmin L Hurd; Fiscal Year: 2013
    ..self-administration paradigm) consistently demonstrated that cannabidiol (CBD), a nonpsychoactive component of cannabis, specifically inhibits cue-induced heroin-seeking behavior...
  34. Cannabidiol Modulation of ???-9-THC???s Psychotomimetic Effects in Healthy Humans
    Mohini Ranganathan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cannabis contains a number of compounds including delta-9-Tetrahydrocannabinol (THC) and cannabidiol (CBD)...
  35. Pharmacological Treatment of Cannabis Withdrawal and Dependence
    Barbara J Mason; Fiscal Year: 2013
    Project Summary / Abstract Cannabis dependence (CD) is a worldwide public health problem...
  36. Is mental disorder a preventable cause of age-related disease? The Dunedin Study.
    TERRIE EDITH MOFFITT; Fiscal Year: 2013
    ..Depression, recurrent Anxiety, chronic Schizophrenia-syndrome, persistent Alcohol Dependence, and persistent Cannabis Dependence will be defined using data from repeated assessments across 20 intervening years in this longitudinal ..
  37. Multilevel Analysis of Self-regulation and Substance Abuse
    Tiffany A Ito; Fiscal Year: 2013
    Awareness of the growing prevalence and deleterious effects of cannabis use has greatly increased over the past decade, making salient the need to better understand the mechanisms that underlie its initiation and progression of use...
  38. Nicotine for Marijuana Withdrawal
    David G Gilbert; Fiscal Year: 2012
    ..provided by applicant): This proposal is in response to RFA-DA-10-016(R01) Medications Development for Cannabis-Related Disorders...
  39. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012
    ..Five groups will be studied: 1) SZ patients with comorbid MA abuse (SZ+MA);2) SZ patients with comorbid cannabis abuse (SZ+MJ);3) SZ patients without comorbid substance abuse (SZ);4) abstinent MA abusers (MA);and 5) matched ..
  40. Examination of endocannabinoid elevation and extinction learning
    JASON MICHAEL WIEBELHAUS; Fiscal Year: 2013
    ..Marijuana (Cannabis sativa) is the most widely used illicit substance in the U.S...
  41. Methods for the Development of Arrestin2 Inhibitors.
    Spiro Pavlopoulos; Fiscal Year: 2010
    ..g. Vicodin, Oxycontin) in addition to illicit drugs (e.g. cannabis)...
  42. Signaling cascades in sensory map development
    Hui Chen Lu; Fiscal Year: 2013
    ..g., cannabis) that might affect the developing fetus...
  43. Developmental Trajectories of Prefrontal Cortical GABA Neurons and Schizophrenia
    Gil D Hoftman; Fiscal Year: 2013
    ..For example, cannabis use during adolescence is associated with an increased risk for cognitive dysfunction and SZ in genetically ..
  44. Endocannabinoid transmission in schizophrenia
    Andrea Giuffrida; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Experimental evidence indicates that cannabis or ?9-tetrahydrocannabinol (THC) use precipitates psychotic symptoms and is associated with a greater risk to develop schizophrenia and worsen its outcome...
  45. Evaluation of harmful effects of cannabis smoke on vascular endothelial function
    MATTHEW LAWRENCE SPRINGER; Fiscal Year: 2012
    ..Then, we will determine whether serum from rats that have been exposed to marijuana mainstream smoke or SHS lowers eNOS activity and NO production in cultured endothelial cells. ..
  46. Epidemiology of Aging Brain and Behavior
    Mary Ganguli; Fiscal Year: 2013
    ..study of cognitive impairment in a cohort of middle-aged women who have been well-characterized for alcohol and cannabis use and followed for 22 years;(ii) secondary analyses of data from the Candidate's four large epidemiologic ..
  47. Deep sequencing studies for cannabis and stimulant dependence
    Kirk C Wilhelmsen; Fiscal Year: 2013
    ..by applicant): The goal of this proposal is to identify genes that affect susceptibility to stimulant and cannabis dependence using whole genome sequencing with genotype imputation...
  48. CHARACTERIZING THE 3-YEAR COURSE OF CANNABIS INVOLVEMENT IN NESARC
    Arpana Agrawal; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Characterizing the 3-year course of cannabis involvement in NESARC Cannabis is the most commonly used illegal psychoactive substance in the United States and in developed nations...
  49. Effects of heavy adolescent cannabis use on brain morphology in aging
    ALISON CLEMENTS BURGGREN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Marijuana (Cannabis sativa) is the most widely used illicit drug worldwide, with 17.4 million Americans reporting past month use in 2010 and 4...
  50. CB1 Mediation of Cerebellum Versus Forebrain-Dependent Associative Learning
    PATRICK DAVID SKOSNIK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Marijuana, or Cannabis sativa, is the most commonly used illicit drug in the United States...
  51. Psychopharmacology of plants and their metabolites used as marijuana substitutes
    Jordan K Zjawiony; Fiscal Year: 2012
    ..Since 1970 when the Controlled Substances Act was enacted into law by Federal Government and cannabis (marijuana) was placed in the Schedule I, a number of marijuana substitutes or alternatives started to appear on ..
  52. Translational Science in Integrative Oncology: From Bedside, to Bench, to Best P
    Suzanna M Zick; Fiscal Year: 2013
    ..and the role of nutrients in gene expression in the context of cancer to the potential therapeutic value of cannabis in integrative oncology;two multidisciplinary integrative tumor boards focusing on best integrative evidence for ..
  53. Role of Sleep in the Treatment of Cannabis Dependence
    Ryan G Vandrey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Approximately 1.2 million Americans were admitted to treatment for cannabis use disorders last year...
  54. Gabapentin Treatment of Cannabis Dependence
    Barbara J Mason; Fiscal Year: 2013
    Project Summary / Abstract Cannabis dependence is a major public health problem...
  55. Decision-Making and Episodic Memory in Trajectories to Cannabis Addiction
    Raul Gonzalez; Fiscal Year: 2013
    Project Summary. More people in the United States are addicted to cannabis than to any other illicit drug, and prevalence of its use is rising, accompanied by a decline in its perceived harm among adolescents...
  56. Quetiapine Pharmacotherapy for Cannabis Dependence
    John J Mariani; Fiscal Year: 2013
    ..The specific aims of the projects are to determine whether quetiapine is superior to placebo in 1) reducing marijuana use and 2) achieving abstinence. ..
  57. Adolescent Cannabis Use, Complex Brain Network Connectivity &Schizophrenia Risk
    Beng Choon Ho; Fiscal Year: 2013
    ..Thus, this proposal with its longitudinal study design and innovative network connectivity measures will advance knowledge regarding the impact adolescent MJ exposure has on public health and on SZ susceptibility. ..
  58. Schizophrenia and Endocannabinoid Effects on Inhibitory Circuitry
    David W Volk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cannabis use by individuals with, or at risk for, schizophrenia is increasingly recognized as a major public health concern...
  59. Imaging the fronto-limbic-striatal circuit in adolescent cannabis users
    JOHN CLYBURN CHURCHWELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overall goal of this application is to examine the effects of cannabis use on decision-making processes in adolescents using magnetic resonance imaging techniques and neurocognitive measures of ..
  60. Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia
    Shaun M Eack; Fiscal Year: 2011
    ..As many as 65% of people with schizophrenia experience significant problems with substance use, most frequently cannabis, and these individuals have the worst course, outcomes, and quality of life...
  61. Endogenous/exogenous cannabinoids: A comparison
    TORBJORN U JARBE; Fiscal Year: 2013
    ..This subjective state presumably underlies human marijuana consumption that may lead to compulsive cannabis intake and dependence disorders...
  62. Targeting tobacco cessation during treatment for cannabis use disorders
    ALAN JEFFREY BUDNEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco...
  63. BIOTRANSFORMATION OF CANNABINOIDS BY MICROORGANISMS
    Larry Robertson; Fiscal Year: 1980
    ..proposed research deals with the metabolism, or biotransformation, of the characteristic chemical constituents of Cannabis sativa L. by selected microorganisms, comprising both fungi and bacteria...
  64. Cannabis and Schizophrenia: Self-Medication and Agonist Treatment?
    Alan I Green; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cannabis use disorder (CUD) occurs frequently in patients with schizophrenia (SCZ) and worsens the course of this severe psychiatric disorder...
  65. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2001
    Marijuana (Cannabis sativa) is the most widely used illegal drug of abuse in the U.S. The active ingredients of this drug, which include delta9-tetrahydrocannabinol (THC), are collectively known as cannabinoids (CBs)...
  66. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2006
    Marijuana (Cannabis sativa) is the most widely used illegal drug of abuse in the U.S. The active ingredients of this drug, which include delta9-tetrahydrocannabinol (THC), are collectively known as cannabinoids (CBs)...
  67. COCAINE, MARIHUANA AND PHENCYCLIDINE INTERACTIONS
    Syed Husain; Fiscal Year: 1990
    ....
  68. CANNABIS AND SCHIZOPHRENIA: CLOZAPINE VS RISPERIDONE
    Alan Green; Fiscal Year: 2005
    DESCRIPTION: (Applicant's Abstract) Cannabis use disorder contributes to the morbidity of schizophrenia, leading to, poorer overall functioning...
  69. Clozapine, cannabis and first episode schizophrenia
    Alan Green; Fiscal Year: 2003
    ..is that CLOZ may be relatively safe and particularly helpful for first episode patients who are comorbid for cannabis use disorder (CUD)...
  70. Imaging dopamine transmission in comorbid schizophrenia and cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2009
    ..dual diagnosis patients suffering from both schizophrenia and addiction, and in particular those suffering from cannabis dependence. Cannabis use is associated with higher risk for schizophrenia and more severe symptomatology...
  71. CANNABIS PHARMACOKINETICS: RELATION TO HUMAN PERFORMANCE
    BARBARA MANNO; Fiscal Year: 1992
    ....
  72. Cannabis & Schizophrenia: fMRI Reward Circuit Biomaker
    Alan Green; Fiscal Year: 2005
    b>Cannabis use disorder (CUD), common in patients with schizophrenia (SCHIZ), contributes greatly to the morbidity of SCHIZ...
  73. Impulsivity and Information Processing in Adolescent Cannabis Abuse
    Donald Dougherty; Fiscal Year: 2007
    This study is designed to determine how chronic adolescent cannabis abuse affects processes of impulsivity, attention, memory, and executive function, and to characterize how these processes are related relationship...
  74. Effects of Zolpidem Extended-Release on Withdrawal and Sleep in Cannabis Users
    Ryan Vandrey; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Treatment admissions for cannabis-related problems have more than doubled since the mid 1990's...
  75. Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
    Leslie H Lundahl; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Despite the high prevalence and problems associated with cannabis related disorders (CRDs), we lack effective medications and research is nascent...
  76. Opioid and Cannabinoid Pharmacokinetic Interactions
    Donald Abrams; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Our primary objective is to assess whether smoking cannabis affects the safety of prescribed opioids in patients treated for cancer-related pain...
  77. PHENCYCLIDINE, METHAQUALONE AND MARIHUANA INTERACTIONS
    Syed Husain; Fiscal Year: 1980
    ..This information will not only enlarge our knowledge about the pharmacology of these agents, but should also aid in the identification and treatment of serious interactions resulting from their abuse...
  78. CANNABINOID RECEPTOR STRUCTURE ACTIVITY RELATIONSHIPS
    ALLYN HOWLETT; Fiscal Year: 2000
    ..Applicant's Abstract) Central nervous system (CNS) responses to delta-9-tetrahydrocannabinol (delta-9-THC) in Cannabis sativa and synthetic cannabimimetic drugs include the therapeutically beneficial effects of analgesia, ..