panax

Summary

Summary: An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).

Top Publications

  1. ncbi Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
    Kwang tae Choi
    Korean Society of Ginseng, Seocho Ku, Seoul 137 862, and Techno Doctor, KOITA, Seoul, Republic of Korea
    Acta Pharmacol Sin 29:1109-18. 2008
  2. ncbi Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
  3. ncbi In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng
    Wei Wang
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, Cancer Pharmacology Laboratory, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Chemother Pharmacol 59:589-601. 2007
  4. pmc De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis
    Chao Sun
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences, Haidian District, Beijing, China
    BMC Genomics 11:262. 2010
  5. pmc Isolation and analysis of ginseng: advances and challenges
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Prod Rep 28:467-95. 2011
  6. ncbi Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research
    Guoxiang Xie
    Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, P R China
    J Sep Sci 31:1015-26. 2008
  7. ncbi Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
    William C S Cho
    School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Hong Kong, China
    Eur J Pharmacol 550:173-9. 2006
  8. ncbi Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    Guizhi Zhang
    Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China
    J Ethnopharmacol 115:441-8. 2008
  9. ncbi An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells
    Insun Hwang
    College of Veterinary Medicine and Applied Radiological Institute, Jeju National University, Jeju, South Korea
    Immunol Lett 138:169-78. 2011
  10. pmc Brief introduction of Panax ginseng C.A. Meyer
    T K Yun
    Laboratory of Experimental Pathology, Korea Cancer Center Hospital, Seoul, Korea
    J Korean Med Sci 16:S3-5. 2001

Research Grants

Detail Information

Publications341 found, 100 shown here

  1. ncbi Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
    Kwang tae Choi
    Korean Society of Ginseng, Seocho Ku, Seoul 137 862, and Techno Doctor, KOITA, Seoul, Republic of Korea
    Acta Pharmacol Sin 29:1109-18. 2008
    Korean Panax ginseng C A Meyer is mainly used to maintain the homeostasis of the body, and the pharmacological efficacy of Korean ginseng identified by modern science includes improved brain function, pain-relieving effects, preventive ..
  2. ncbi Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
    We evaluated antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates...
  3. ncbi In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng
    Wei Wang
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, Cancer Pharmacology Laboratory, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Chemother Pharmacol 59:589-601. 2007
    b>Panax ginseng and its extracts have long been used for medical purposes; there is increasing interest in developing ginseng products as cancer preventive or therapeutic agents...
  4. pmc De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis
    Chao Sun
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences, Haidian District, Beijing, China
    BMC Genomics 11:262. 2010
    American ginseng (Panax quinquefolius L.) is one of the most widely used herbal remedies in the world. Its major bioactive constituents are the triterpene saponins known as ginsenosides...
  5. pmc Isolation and analysis of ginseng: advances and challenges
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Prod Rep 28:467-95. 2011
    ..The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques...
  6. ncbi Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research
    Guoxiang Xie
    Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, P R China
    J Sep Sci 31:1015-26. 2008
    In this study, metabolite profiling of five medicinal Panax herbs including Panax ginseng (Chinese ginseng), Panax notoginseng (Sanchi), Panax japonicus (Rhizoma Panacis Majoris), Panax quinquefolium L. (American ginseng), and P...
  7. ncbi Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats
    William C S Cho
    School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Hong Kong, China
    Eur J Pharmacol 550:173-9. 2006
    ..In this study, when diabetic rats were treated with ginsenoside Re of Panax ginseng C.A. Meyer, there was a significant reduction in blood glucose, total cholesterol and triglyceride levels...
  8. ncbi Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    Guizhi Zhang
    Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China
    J Ethnopharmacol 115:441-8. 2008
    Ginsenosides, the major active ingredients of Panax ginseng, produce a variety of pharmacological or physiological responses with effects on the central and peripheral nervous systems.
  9. ncbi An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells
    Insun Hwang
    College of Veterinary Medicine and Applied Radiological Institute, Jeju National University, Jeju, South Korea
    Immunol Lett 138:169-78. 2011
    An acidic polysaccharide of Panax ginseng (APG), so called ginsan, is a purified polysaccharide...
  10. pmc Brief introduction of Panax ginseng C.A. Meyer
    T K Yun
    Laboratory of Experimental Pathology, Korea Cancer Center Hospital, Seoul, Korea
    J Korean Med Sci 16:S3-5. 2001
    ..In Aisa, particularly, Panax ginseng C.A...
  11. ncbi Panax ginseng enhances cognitive performance in Alzheimer disease
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Alzheimer Dis Assoc Disord 22:222-6. 2008
    ..Thus, we investigated the clinical efficacy of Panax ginseng in the cognitive performance of AD patients in an open-label study...
  12. ncbi Ginsenosides: are any of them candidates for drugs acting on the central nervous system?
    Seung Yeol Nah
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    CNS Drug Rev 13:381-404. 2007
    The last two decades have shown a marked expansion in the number of publications regarding the effects of Panax ginseng...
  13. ncbi Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling
    Bai Cheng He
    Department of Pharmacology and the Key Laboratory of Diagnostic Medicine designated by Chinese Ministry of Education, Chongqing Medical University, Chongqing, PR China
    Int J Oncol 38:437-45. 2011
    ..Ginsenoside Rg3 is a single compound isolated from American ginseng (Panax quinquefolius L., Araliaceae) and Asian ginseng (Panax ginseng C. A. Meyer)...
  14. pmc Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides
    Huai You Wang
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
    Am J Chin Med 39:1103-15. 2011
    ..In summary, the intestinal microbiota may play an important role in mediating the metabolism bioactivity of herbal medicines...
  15. ncbi Ginsenoside content of berries and roots of three typical Korean ginseng (Panax ginseng) cultivars
    Yong Kyoung Kim
    Division of Plant Science and Resources, Chungnam National University, Daejeon, 305 754, Korea
    Nat Prod Commun 4:903-6. 2009
    ..The total amount of ginsenosides (especially Rb1, Re, and Rg1) was greatest in the Yunpoong cultivar...
  16. ncbi Panax ginseng: a systematic review of adverse effects and drug interactions
    Joanna Thompson Coon
    Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, United Kingdom
    Drug Saf 25:323-44. 2002
    b>Panax ginseng C. A. Meyer is a perennial herb native to Korea and China and has been used as an herbal remedy in eastern Asia for thousands of years...
  17. pmc Ginsenosides from American ginseng: chemical and pharmacological diversity
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Phytochemistry 72:689-99. 2011
    ..The goal is that this article is a useful reference to chemists and biologists researching American ginseng, and will open the door to agents in drug discovery...
  18. ncbi Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng
    Nam Hun Lee
    Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, Korea
    J Acupunct Meridian Stud 4:85-97. 2011
    ..All randomized clinical trials evaluating the clinical effects or safety of the use of ginseng monopreparations (Panax ginseng or P. quinquefolium) were considered for inclusion...
  19. ncbi The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
    K A Wesnes
    Cognitive Drug Research Ltd, Reading, UK
    Psychopharmacology (Berl) 152:353-61. 2000
    ..containing 60 mg of a standardised extract of Ginkgo biloba (GK501) and 100 mg of a standardised extract of Panax ginseng (G115) on various aspects of cognitive function were assessed in healthy middle-aged volunteers...
  20. ncbi Complete chloroplast genome sequences from Korean ginseng (Panax schinseng Nees) and comparative analysis of sequence evolution among 17 vascular plants
    Ki Joong Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    DNA Res 11:247-61. 2004
    The nucleotide sequence of Korean ginseng (Panax schinseng Nees) chloroplast genome has been completed (AY582139)...
  21. ncbi American ginseng: potential structure-function relationship in cancer chemoprevention
    Lian Wen Qi
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, United States
    Biochem Pharmacol 80:947-54. 2010
    ..Understanding these relationships may produce insights into chemical and pharmacological approaches for enhancing the chemopreventive effects of ginsenoside and for developing novel anticancer agents...
  22. ncbi Radioprotective potential of ginseng
    Tung Kwang Lee
    Department of Radiation Oncology, Leo W Jenkins Cancer Center, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Mutagenesis 20:237-43. 2005
    ..In general, ginseng refers to the roots of the species of the genus Panax. As a medicinal herb, ginseng has been widely used in traditional Chinese medicine for its wide spectrum of ..
  23. ncbi Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130 701, Republic of Korea
    Biochem Pharmacol 82:278-86. 2011
    In the preliminary study, ginsenoside Rb1, a main constituent of the root of Panax ginseng (family Araliaceae), and its metabolite compound K inhibited a key factor of inflammation, nuclear transcription factor κB (NF-κB) activation, ..
  24. ncbi Modulating angiogenesis: the yin and the yang in ginseng
    Shiladitya Sengupta
    Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Cambridge, UK
    Circulation 110:1219-25. 2004
    ..To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules from ginseng extract on angiogenesis...
  25. pmc Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds
    S Shibata
    Shibata Laboratory of Natural Medicinal Materials c/o Minophagen Pharmaceutical Co. Ltd, Tokyo, Japan
    J Korean Med Sci 16:S28-37. 2001
    ..than 25 dammarane-type tetracyclic triterpenoid saponins have been isolated from ginseng, the root and rhizome of Panax ginseng C.A. Meyer (Araliaceae)...
  26. ncbi Pharmacological activity of sanchi ginseng (Panax notoginseng)
    T B Ng
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Pharm Pharmacol 58:1007-19. 2006
    The pharmacological activity and constituents of the sanchi ginseng Panax notoginseng have been reviewed...
  27. ncbi Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control
    Su Na Kim
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110 460, South Korea
    J Pharm Biomed Anal 45:164-70. 2007
    ..was developed for the simultaneous quantification of 14 major ginsenosides, which are the marker compounds of Panax ginseng C.A. Meyer (Korean red ginseng)...
  28. ncbi Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model
    Tae Woo Kim
    Gu Jeong High School, Gangnam Ku, Seoul, Korea
    Planta Med 75:836-9. 2009
    The anxiolytic-like effects of red ginseng (RG, the steamed root of Panax ginseng, family Araliaceae), its saponin fraction, and its representative constituents, ginsenosides Rg3 and Rh2, were investigated in mice using the elevated plus-..
  29. ncbi A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice
    Sung Dong Lee
    Department of Food and Nutrition, College of Health Science, Korea University, Seoul, Republic of Korea
    J Med Food 13:1-5. 2010
    ..This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route...
  30. ncbi Ginsenoside Rh2 reduces ischemic brain injury in rats
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 27:433-6. 2004
    ..7 cells, but showed no in vitro antioxidant activity. These results suggest that AG and ginsenoside Rh2 can improve ischemic brain injury...
  31. ncbi Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP)
    Han Jae Shin
    KT and G Central Research Institute, Daejeon, Korea
    Planta Med 70:1033-8. 2004
    We have recently reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C.A...
  32. ncbi Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease
    Hitoshi Kaneko
    Kaneko Heart Clinic, Matsuyama, Japan
    J Pharmacol Sci 95:158-62. 2004
    ..Furthermore, we confirmed the preventive effects of medical ginseng on the common cold symptom complex, including flu, by clinical observation. Here, we report our experiences...
  33. ncbi Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study
    Soyun Cho
    Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Republic of Korea
    J Med Food 12:1252-9. 2009
    ..These results substantiate the alleged beneficial effects of red ginseng on photoaging and support its use as an effective "beauty food."..
  34. ncbi Effects of Panax ginseng extract on exercise-induced oxidative stress
    S H Kim
    Department of Exercise Science, Chungbuk National University, Cheongju, Korea
    J Sports Med Phys Fitness 45:178-82. 2005
    This study was designed to study the effects of Panax ginseng extract (PGE) on lipid peroxidation and scavenger enzymes induced by an acute exhaustive exercise in sedentary humans.
  35. ncbi Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review
    Davy C W Lee
    Cytokine Biology Group, Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Molecules 16:2802-16. 2011
    b>Panax ginseng is one of the most commonly used Chinese medicines in China, Asia and Western countries. The beneficial effects of ginseng have been attributed to the biological activities of its constituents, the ginsenosides...
  36. ncbi Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng
    Tae Dong Kim
    Division of Forest Resources, Kangwon National University, Chunchon 200 701, Republic of Korea
    Plant Cell Physiol 52:125-37. 2011
    ..that PgSS1 overexpression results in the enhanced biosynthesis of both phytosterols and triterpene saponins in Panax ginseng. Here, cDNAs encoding two new SQS homologs (PgSS2 and PgSS3) from a P...
  37. ncbi Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    J Ethnopharmacol 132:206-12. 2010
    Red Ginseng roots (Panax ginseng C.A. Meyer) have traditionally been thought to have anti-allergic effects, but their influence on food-induced allergic responses is unclear.
  38. ncbi Effects of nonsaponin fraction of red ginseng on learning deficits in aged rats
    Hiroaki Kurimoto
    System Emotional Science, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, 930 0194, Japan
    Physiol Behav 82:345-55. 2004
    ....
  39. pmc Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
    Binghui Li
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, United States
    Cancer Lett 289:62-70. 2010
    ..These results further suggest that the anti-cancer effect of steamed ginseng can be enhanced by antioxidants or inhibitors of the NF-kappaB pathway...
  40. ncbi American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus
    V Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, St Michael s Hospital, Ontario, Canada
    Arch Intern Med 160:1009-13. 2000
    ..We therefore undertook a preliminary short-term clinical study to assess whether American ginseng (Panax quinquefolius L) affects postprandial glycemia in humans.
  41. ncbi Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection
    Fu Shi Quan
    Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, United States
    Vaccine 25:272-82. 2007
    ..Therefore, these results indicate that both ginseng and Salviae play a role as mucosal adjuvants against influenza virus as well as immuno-modulators during influenza virus infection...
  42. ncbi Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng
    Jung Yeon Han
    Division of Forest Resources, College of Forest and Environmental Sciences, Kangwon National University, Chunchon 200 701, Republic of Korea
    Phytochemistry 71:36-46. 2010
    ..the roles of two squalene epoxidase genes (PgSQE1 and PgSQE2) in triterpene and phytosterol biosynthesis in Panax ginseng. PgSQE1 and PgSQE2 encoded deduced proteins of 537 and 545 amino acids, respectively...
  43. ncbi Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism
    Myoung Su Lee
    Biogeron Research Center, Korea Food Research Institute, Bundang Ku, Songnam, Republic of Korea
    J Ethnopharmacol 127:771-6. 2010
    b>Panax ginseng and its major component, ginsenosides, are widely used for the prevention of various disorders in oriental medicine.
  44. ncbi Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice
    Mohammad Lalmoddin Mollah
    College of Veterinary Medicine, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Phytother Res 23:220-5. 2009
    The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks...
  45. pmc High-throughput sequencing and characterization of the small RNA transcriptome reveal features of novel and conserved microRNAs in Panax ginseng
    Bin Wu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 7:e44385. 2012
    ..However, no information is available for miRNAs from Panax ginseng, an economically significant medicinal plant species...
  46. pmc Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, University of Chicago, IL 60637, USA
    Am J Chin Med 39:1161-71. 2011
    ..4 ng⋅h/ml for C-K, respectively. The gradual decrease of Rb1 levels and the delayed increase in levels of C-K observed in human subjects supported previous reports that enteric microbiota played a key role in transforming Rb1 to C-K...
  47. ncbi Three new dammarane-type triterpene saponins from the leaves of Panax ginseng C.A. Meyer
    Gui Ying Liu
    Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, China
    J Asian Nat Prod Res 12:865-73. 2010
    ..new dammarane-type triterpene ginsenosides, together with six known ginsenosides, were isolated from the leaves of Panax ginseng C.A. Meyer...
  48. ncbi Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice
    Tong Ho Kang
    Department of Oriental Medicinal Materials and Processing, College of Life Sciences, Kyung Hee University, Global Campus, Seocheon dong, Giheung gu, Yongin si, Gyeonggi Do 446 701, Republic of Korea
    J Ethnopharmacol 123:446-51. 2009
    b>Panax ginseng C.A. Meyer, Korean herb medicine, has been widely used in China and Japan for fatigue and enhancement of resistance to many diseases.
  49. ncbi Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats
    Seo Hee Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120 752, Korea
    Phytother Res 26:142-7. 2012
    ..The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal ..
  50. ncbi Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells
    Ju Hee Kang
    Division of Cancer Biology, National Cancer Center, Ilsandong gu, Goyang si, Gyeonggi Do, Republic of Korea
    Plant Foods Hum Nutr 66:298-305. 2011
    ..One such natural agent is ginseng (Panax ginseng), which is traditionally used in some parts of the world as a popular remedy for various diseases ..
  51. ncbi Ginseng supplementation does not change lactate threshold and physical performances in physically active Thai men
    Onanong Kulaputana
    Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    J Med Assoc Thai 90:1172-9. 2007
    ..Ginseng has been one of the most popular herbs said to improve human exercise performance. Unclear and anecdotal information is known about the effect of ginseng on lactate threshold and aerobic performance in humans...
  52. ncbi Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells
    Qiu Hua Zhang
    Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, PR China
    Food Chem Toxicol 46:293-302. 2008
    ..Ginsenosides are biological active constituents of Panax ginseng C.A...
  53. ncbi Panax ginseng
    David Kiefer
    Program in Integrative Medicine, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Am Fam Physician 68:1539-42. 2003
    ..One of the most commonly used and researched of the ginsengs is Panax ginseng, also called Asian or Korean ginseng...
  54. ncbi Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study
    Deepak Rai
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    J Pharmacol Sci 93:458-64. 2003
    ..biloba, 30 mg/kg, p.o.) and compared it with that of Panax ginseng (P. ginseng, 100 mg/kg, p.o.) against acute stress (AS) and chronic stress (CS) models in rats...
  55. ncbi Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro
    Patrick Y K Yue
    Hung Lai Ching Laboratory of Biomedical Science, Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong
    Angiogenesis 8:205-16. 2005
    ..Our results suggest that Rg(1) can promote angiogenesis in multiple models, and this effect is partly due to the modulation of genes that are involved in the cytoskeletal dynamics, cell-cell adhesion and migration...
  56. ncbi Detection of Panax quinquefolius in Panax ginseng using 'subtracted diversity array'
    Linhai Niu
    School of Applied Sciences, Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3000, Australia
    J Sci Food Agric 91:1310-5. 2011
    ..Further, we used a subtracted diversity array (SDA) to fingerprint the two ginseng species, Panax ginseng and Panax quinquefolius, that are frequently mixed for adulteration.
  57. ncbi Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats
    T P Liu
    Department of General Surgery, Mackay Memorial Hospital, and Mackay Nursing College, Taipei City, Taiwan, R O C
    Horm Metab Res 37:146-51. 2005
    In an attempt to probe a new target for handling insulin resistance, we used Panax ginseng root to screen the effect on insulin resistance induced by fructose-rich chow in rats...
  58. ncbi Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng)
    B M Lee
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Cancer Lett 132:219-27. 1998
    ..3%). These preliminary data suggest that supplementation with antioxidants might protect smokers from oxidative damages and could reduce cancer risk or other diseases caused by free radicals associated with smoking...
  59. pmc American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages
    Tomonaga Ichikawa
    Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA
    J Ethnopharmacol 125:145-50. 2009
    ..Thus, we investigated the effect of a crude extract from Panax quinquefolius (American ginseng) on suppression of pro-inflammatory responses in macrophages with a focus on ..
  60. pmc Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA
    Planta Med 73:669-74. 2007
    Red Asian ginseng ( Panax ginseng C. A. Meyer, Araliaceae) is used in many Oriental countries. In this study, the saponin constituents and anticancer activities of steamed American ginseng ( Panax quinquefolius L.) roots were evaluated...
  61. ncbi Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng
    Yi Seong Kwak
    Korea Ginseng Corporation Central Research Institute, Daejon 305 805, Korea
    Biol Pharm Bull 33:468-72. 2010
    ..Therefore, our data suggest that RGAP may play an additional role in reducing hyperlipidemic conditions, which can be used as a valuable neutraceutical application for the treatment of hyperlipidemia...
  62. ncbi Antiplatelet and anticoagulant effects of Panax notoginseng: comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium
    Aik Jiang Lau
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    J Ethnopharmacol 125:380-6. 2009
    b>Panax notoginseng (Burk.) F. H. Chen (Araliacea) is traditionally used for its hemostatic and cardiovascular effects when raw and as a tonic when steamed.
  63. ncbi Ginseng and diabetes
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Chin Med 33:397-404. 2005
    ..Ginseng has also been commonly used in Oriental medicine to treat diabetes-like conditions. The present review discusses the research on the anti-diabetic effects of ginseng and the possible mechanisms of its anti-diabetic actions...
  64. ncbi Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium
    Chieh Fu Chen
    Institute of Pharmacology, National Yang Ming University, Taipei, China
    Acta Pharmacol Sin 29:1103-8. 2008
    Medical application of Panax ginseng was first found in "Shen-Nong Herbal Classic"around 200 AD Panax quinquefolium was first introduced in "Essential of Materia Medica" in 1694 in China...
  65. ncbi Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer
    Jia Wang
    School of Life Sciences, Northeast Normal University, Changchun, PR China
    J Ethnopharmacol 130:421-3. 2010
    b>Panax ginseng C. A. Meyer (ginseng) is a well-known Chinese herb often used in Asian countries for physical strength development. Ginseng polysaccharides are its active component and have a lot of pharmaceutical activities...
  66. ncbi Steamed American ginseng berry: ginsenoside analyses and anticancer activities
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, Illinois 60637, USA
    J Agric Food Chem 54:9936-42. 2006
    ..The steaming of American ginseng berries augments ginsenoside Rg3 content and increases the antiproliferative effects on two human colorectal cancer cell lines...
  67. ncbi Ginseng: potential for the enhancement of cognitive performance and mood
    David O Kennedy
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, RG30 1EA, UK
    Pharmacol Biochem Behav 75:687-700. 2003
    ..It is suggested that ginseng would benefit from rigorous research further delineating its acute effects and exploring the relationship between acute effects and those seen during and following chronic administration regimens...
  68. ncbi Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling
    Vincent Kam Wai Wong
    Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China
    J Cell Biochem 111:899-910. 2010
    ..This is the first report demonstrating possible combination of EAG with proteasome inhibitors could be a novel strategy in anti-cancer treatment...
  69. ncbi Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats
    Qing Fang Xu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, People s Republic of China
    J Ethnopharmacol 84:187-92. 2003
    b>Panax notoginseng is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Chinese medicine. Currently saponins of P. notoginseng (PNS) are especially given attentions for their hemorheological properties...
  70. ncbi Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats
    Hyun Joo Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120 752, Korea
    Metabolism 58:1170-7. 2009
    ..In this study, we investigated the metabolic effects and putative molecular mechanisms of Korean red ginseng (KRG, Panax ginseng) in animal models for type 2 diabetes mellitus (T2DM) and peripheral insulin-responsive cell lines...
  71. ncbi Free radical scavenging activity of red ginseng aqueous extracts
    Yoo K Kim
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Toxicology 172:149-56. 2002
    This study was performed to investigate the free radical scavenging activity of Panax red ginseng C.A...
  72. ncbi Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    Na Li
    Department of Physiology, Medical College of Qingdao University, Qingdao 266071, PR China
    J Ethnopharmacol 111:458-63. 2007
    ..In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Abeta1-40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease...
  73. ncbi Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety
    Vladimir Vuksan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Nutr Metab Cardiovasc Dis 18:46-56. 2008
    ....
  74. ncbi Oral ginseng formulae for stable chronic obstructive pulmonary disease: a systematic review
    Xuedong An
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia
    Respir Med 105:165-76. 2011
    ..Ginseng formulae for stable COPD patients show promising evidence of lung functions and Qol improvement. However, the degree of benefit is uncertain due to potential risk of bias of the included studies...
  75. pmc Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells
    Xiaoji Luo
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
    Int J Oncol 32:975-83. 2008
    American ginseng (Panax quinquefolius L., Araliaceae) possesses anti-cancer potential and is one of the most commonly used herbal medicines in the United States...
  76. ncbi Antiallergic activity of ginseng and its ginsenosides
    Min Kyung Choo
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 69:518-22. 2003
    In this study, we measured the antiallergic activities of ginsenosides isolated from the root of Panax ginseng ( Araliaceae), and of their metabolites, as produced by human intestinal bacteria...
  77. ncbi The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals
    Ji Yeon Ahn
    Laboratory of Radiation Immunology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Eur J Immunol 36:37-45. 2006
    Ginsan, a polysaccharide extracted from Panax ginseng, has multiple immunomodulatory effects. In this study, we show that pretreatment of ginsan (25 mug/kg) protected mice from lethality induced by Staphylococcus aureus challenge...
  78. ncbi Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants
    T Kushiro
    The Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Eur J Biochem 256:238-44. 1998
    ..A homology-based PCR method was attempted to obtain the cDNA of this enzyme from the hairy root of Panax ginseng which produces oleanane saponins together with dammarane-type saponins...
  79. ncbi Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells
    Ava Rhule
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812 1552, USA
    J Ethnopharmacol 106:121-8. 2006
    ..Therefore, the immunomodulatory effects of the herbal extract Panax notoginseng on cultured macrophages (RAW264...
  80. ncbi 454 EST analysis detects genes putatively involved in ginsenoside biosynthesis in Panax ginseng
    S Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Haidian, Beijing 100193, China
    Plant Cell Rep 30:1593-601. 2011
    b>Panax ginseng C.A. Meyer is one of the most highly valued medicinal plants in the world. To analyze the transcriptome of P...
  81. ncbi Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro
    Ho Jae Han
    Department of Veterinary Physiology, College of Veterinary Medicine, Hormone Research Center, Chonnam National University, Kwangju 500 757, Korea
    Planta Med 68:971-4. 2002
    ..Abbreviations. EGF:epidermal growth factor PD:protopanaxadiol PT:protopanaxatriol PTCs:primary cultured renal proximal tubule cells..
  82. pmc American ginseng suppresses inflammation and DNA damage associated with mouse colitis
    Yu Jin
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, SC 29208, USA
    Carcinogenesis 29:2351-9. 2008
    ..Results are consistent with this hypothesis. The use of American ginseng extract represents a novel therapeutic approach for the prevention and treatment of UC...
  83. ncbi Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The University of Chicago, Chicago, Illnois 60637, USA
    J Agric Food Chem 54:2261-6. 2006
    ..was ginsenoside Rb3, while Rb3 only had limited amounts in the root of American ginseng and other species of the Panax genus. Ginsenoside Rb3 was quantified as 4.71% in American ginseng leaves and 5...
  84. ncbi Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene
    Mi Hyun Lee
    Korea Ginseng Institute, Chung Ang University, Ansung 456 756, Kyunggi Do, Korea
    Plant Cell Physiol 45:976-84. 2004
    Roots of Panax ginseng, one of the most famous medicinal plants, contain various phytosterols and bioactive triterpene saponins (ginsenosides). In P...
  85. ncbi Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
    Pimpimon Tansakul
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    FEBS Lett 580:5143-9. 2006
    b>Panax ginseng produces triterpene saponins called ginsenosides, which are classified into two groups by the skeleton of aglycones, namely dammarane type and oleanane type...
  86. ncbi Photoprotective effect of red ginseng against ultraviolet radiation-induced chronic skin damage in the hairless mouse
    Hae June Lee
    Korea Institute of Radiological and Medical Science, Seoul 139 240, South Korea
    Phytother Res 23:399-403. 2009
    ..2% (topical administration) in the RG treated groups. It is noted that skin that is chronically exposed to UV is subject to photoaging and photocarcinogenesis and the regular use of RG would prevent these photodamaging effects of UV...
  87. pmc Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell proliferation by American ginseng (Panax quinquefolius) and its constituents
    M L King
    Southern Illinois University, School of Medicine, Department of Physiology, Carbondale, IL 62901, USA
    Phytomedicine 17:261-8. 2010
    ..This study suggests that p21 functions to arrest HCT116 wild-type cells treated with GE, while p21-deficient cells undergo cell death in a ginseng constituent-dependent manner...
  88. ncbi Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium)
    M Wang
    CV Technologies Inc, Alberta, Canada
    J Pharm Pharmacol 53:1515-23. 2001
    ..CVT-E002, an aqueous extract containing mainly oligosaccharides and polysaccharides from North American ginseng (Panax quinquefolium), as an immunobooster on murine spleen cells and peritoneal macrophages, was studied in-vitro...
  89. ncbi Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells
    Kun Zou
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan
    J Nat Prod 65:1288-92. 2002
    ..yesanchinosides G-J, together with nine ginsenosides (5-13) were isolated from Ye-Sanchi, the underground part of Panax japonicus collected in the south of Yunnan Province, China...
  90. ncbi In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, University of Chicago, IL 60637, USA
    Biol Pharm Bull 32:1552-8. 2009
    b>Panax ginseng roots, including the steamed roots, have been demonstrated to possess anticancer properties. However, there have been limited published studies on the cancer preventive effects of American ginseng...
  91. ncbi Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatocytoprotective activity
    Q L Tran
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    J Nat Prod 64:456-61. 2001
    The methanol extract of Vietnamese ginseng (Panax vietnamensis) was found to possess hepatocytoprotective effects on D-galactosamine (D-GalN)/tumor necrosis factor-alpha (TNF-alpha)-induced cell death in primary cultured mouse ..
  92. ncbi Non-organ-specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers
    Taik Koo Yun
    Korea Institute of Cancer Chemoprevention, Seoul, Republic of Korea
    J Med Food 13:489-94. 2010
    Previously, two case-control studies and a cohort study strongly suggested that Panax ginseng C.A. Meyer exerted non-organ-specific preventive effects against cancer...
  93. ncbi Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 33:1077-81. 2010
    ..This study provides scientific evidence that 20(S)-Rg(3) prevents the progression of renal damage and dysfunction in type 2 diabetic rats via inhibiting oxidative stress and advanced glycation endproduct formation...
  94. ncbi Protective effect of sun ginseng against diabetic renal damage
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:1678-84. 2006
    The effect of sun ginseng (SG, heat-processed Panax ginseng C. A. MEYER at 120 degrees C) on diabetic renal damage was investigated using streptozotocin-induced diabetic rats...
  95. ncbi Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease
    Paul Chan
    Division of Cardiovascular Medicine, Taipei Medical College Affiliated Taipei Wan Fang Hospital, Taipei, China
    Acta Pharmacol Sin 23:1157-62. 2002
    Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng...
  96. pmc The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Oncol Rep 21:577-84. 2009
    ..The mitochondrial pathway may play a key role in American ginseng-mediated cancer cell apoptosis...
  97. ncbi Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng
    Jung Yeon Han
    College of Pharmacy, Kangwon National University, Chunchon 200 701, Republic of Korea
    Plant Cell Physiol 47:1653-62. 2006
    b>Panax ginseng is one of the most highly valued herbal medicines in the Orient, where it has gained an almost magical reputation for being able to maintain the quality of life...
  98. ncbi Panax ginseng: a role in cancer therapy?
    Yuan S Chang
    School of Pharmacy, China Medical College, Taichung, Taiwan, Republic of China
    Integr Cancer Ther 2:13-33. 2003
    b>Panax ginseng is a plant that has been used in traditional medicine in China for thousands of years...
  99. ncbi A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration
    Ya Chun Huang
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
    Pharm Res 22:636-46. 2005
    ..In this study, the feasibility of using a natural compound, ginsenoside Re, isolated from Panax ginseng in stimulating angiogenesis and for tissue regeneration was evaluated.
  100. ncbi High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng
    Aik Jiang Lau
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543, Singapore
    J Chromatogr A 1057:141-9. 2004
    ..with chromatographic pattern matching was developed to differentiate whole chromatograms of raw and steamed Panax notoginseng objectively and quantitatively...
  101. ncbi Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection
    Aik Jiang Lau
    Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    J Chromatogr A 1011:77-87. 2003
    ..determination of six saponins (notoginsenoside R1, ginsenosides Rg1, Re, Rb1, Rc, Rd) in raw and steamed Panax notoginseng. Linearity (r2 > 0.9988), intra- and inter-day precision (RSD < 4%), limit of detection (0.008-0...

Research Grants18

  1. R21 Project: Anti-diabetic Effects of Panax ginseng
    Chun Su Yuan; Fiscal Year: 2003
    ..This proposal will focus on our studies on anti-diabetic effects of Panax ginseng, and this project is a continuation of our previous ginseng pharmacological studies...
  2. Development and validation of DNA sequence-based methods of medicinal herb specie
    DANICA TAYLOR HARBAUGH REYNAUD; Fiscal Year: 2012
    ..each of the following five species: licorice (Glycyrrhiza uralensis), goldenseal (Hydrastis canadensis), ginseng (Panax quinquefolius), rhubarb (Rheum palmatum), and skullcap (Scutellaria lateriflora);these five species were chosen ..
  3. Nitric oxide as a target for dietary intervention in colitis
    Michael Wargovich; Fiscal Year: 2007
    ..Here, we postulate that two antioxidant herbal supplements, Ginkgo biloba and American ginseng (Panax quinquefolis), will inhibit colitis through the inhibition of nitric oxide synthase, inhibiting subsequent nitric ..
  4. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006
    ..Accomplishing these aims will provide an essential prerequisite to the development of NAGE as an effective radioprotector. ..
  5. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  6. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
    ....
  7. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  8. DIETARY FATTY CONTROL OF INFLAMMATION
    Kevin High; Fiscal Year: 2002
    ..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
  9. Functional Senescence of Innate Immunity and Pneumonia
    Kevin High; Fiscal Year: 2003
    ..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
  10. Brucella, Aging and Role of IL-17 in Host Defense
    Kevin High; Fiscal Year: 2005
    ..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
  11. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet McElhaney; Fiscal Year: 2004
    ..The goal is to define an immunologic test that measures influenza risk, a measure critical to future vaccine development and targeted prophylaxis in older adults. ..
  12. Anti-Cancer Ginsenosides: Their Interactions and Mechanisms of Action
    Laura Murphy; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    ..abstract_text> ..
  14. Integrating Aging and Cancer Research
    Robert Wallace; Fiscal Year: 2007
    ..Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development. ..
  15. Adjuvant Ginseng Use During Breast Cancer Drug Therapy
    Laura Murphy; Fiscal Year: 2005
    ....
  16. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet E McElhaney; Fiscal Year: 2010
    ..3) Test heat shock proteins (Hsp) as potential vaccine adjuvants to enhance the CTL response to vaccination. ..
  17. Herb Drug Interactions
    Gary Henderson; Fiscal Year: 2004
    ..abstract_text> ..