plant bark

Summary

Summary: The outer layer of the woody parts of plants.

Top Publications

  1. ncbi Antioxidant properties of Indian medicinal plants
    Hemant R Jadhav
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062 Punjab, India
    Phytother Res 16:771-3. 2002
  2. ncbi Antimicrobial activity of Ximenia americana
    M E F A Omer
    Medicinal and Aromatic Plants Research Institute, National Centre for Research, PO Box 2404, Khartoum, Sudan
    Fitoterapia 74:122-6. 2003
  3. ncbi Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers
    B Berenguer
    Department of Pharmacology, Faculty of Pharmacy, Profesor García González Street No 2, 41012 Seville, Spain
    J Ethnopharmacol 103:194-200. 2006
  4. ncbi Anthelmintic activities of three medicinal plants from Nigeria
    A A Gbolade
    Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria
    Fitoterapia 79:223-5. 2008
  5. pmc Involvement of HbPIP2;1 and HbTIP1;1 aquaporins in ethylene stimulation of latex yield through regulation of water exchanges between inner liber and latex cells in Hevea brasiliensis
    Kessarin Tungngoen
    Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Plant Physiol 151:843-56. 2009
  6. ncbi Angiosperm bark volatiles disrupt response of Douglas-fir beetle, Dendroctonus pseudotsugae, to attractant-baited traps
    D P Huber
    Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6
    J Chem Ecol 27:217-33. 2001
  7. ncbi Ethylene stimulation of latex yield depends on the expression of a sucrose transporter (HbSUT1B) in rubber tree (Hevea brasiliensis)
    Anaïs Dusotoit-Coucaud
    Clermont Universite, Universite Blaise Pascal, UMRA 547 PIAF, F 63177 Aubiere, France
    Tree Physiol 30:1586-98. 2010
  8. pmc Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Malar J 10:167. 2011
  9. ncbi Nitrogen nutrition of poplar trees
    H Rennenberg
    Albert Ludwigs University Freiburg, Institute of Forest Botany and Tree Physiology, Freiburg, Germany
    Plant Biol (Stuttg) 12:275-91. 2010
  10. ncbi Cinnamon zeylanicum bark extract and powder mediated green synthesis of nano-crystalline silver particles and its bactericidal activity
    M Sathishkumar
    Environmental Biotechnology National Research Laboratory, School of Chemical Engineering, Research Institute of Industrial Technology, Chonbuk National University, Jeonju 561 756, Republic of Korea
    Colloids Surf B Biointerfaces 73:332-8. 2009

Research Grants

  1. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
  2. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
  3. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
  4. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
  5. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005

Detail Information

Publications241 found, 100 shown here

  1. ncbi Antioxidant properties of Indian medicinal plants
    Hemant R Jadhav
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062 Punjab, India
    Phytother Res 16:771-3. 2002
    ..The selective pigment removal from the extracts led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation...
  2. ncbi Antimicrobial activity of Ximenia americana
    M E F A Omer
    Medicinal and Aromatic Plants Research Institute, National Centre for Research, PO Box 2404, Khartoum, Sudan
    Fitoterapia 74:122-6. 2003
    ..Extracts of the bark, leaves, root and stem of Ximenia americana were tested for their antimicrobial and antifungal activity...
  3. ncbi Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers
    B Berenguer
    Department of Pharmacology, Faculty of Pharmacy, Profesor García González Street No 2, 41012 Seville, Spain
    J Ethnopharmacol 103:194-200. 2006
    ..These results suggest that the gastroprotective effect of Rhizophora mangle in this experimental model appears through an antioxidant and prostaglandin-dependent way...
  4. ncbi Anthelmintic activities of three medicinal plants from Nigeria
    A A Gbolade
    Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria
    Fitoterapia 79:223-5. 2008
    ..mombin which exhibited comparatively higher efficacy (34-44 min paralysis time and 105 min death time for the leaf) at lower concentrations of 10-20 mg/ml were adjudged the outstanding anthelmintics of plant origin accordingly...
  5. pmc Involvement of HbPIP2;1 and HbTIP1;1 aquaporins in ethylene stimulation of latex yield through regulation of water exchanges between inner liber and latex cells in Hevea brasiliensis
    Kessarin Tungngoen
    Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Plant Physiol 151:843-56. 2009
    ....
  6. ncbi Angiosperm bark volatiles disrupt response of Douglas-fir beetle, Dendroctonus pseudotsugae, to attractant-baited traps
    D P Huber
    Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6
    J Chem Ecol 27:217-33. 2001
    ..Nonhost angiosperm bark volatiles may have practical utility on their own or in combination with the antiaggregation pheromone 3-methylcyclohex-3-en-1-one (MCH) to protect single trees, logs, or stands from attack by the DFB...
  7. ncbi Ethylene stimulation of latex yield depends on the expression of a sucrose transporter (HbSUT1B) in rubber tree (Hevea brasiliensis)
    Anaïs Dusotoit-Coucaud
    Clermont Universite, Universite Blaise Pascal, UMRA 547 PIAF, F 63177 Aubiere, France
    Tree Physiol 30:1586-98. 2010
    ..A positive correlation with HbSUT1B transcript accumulation and increased latex production was further supported by its lower expression in latex cells of the virgin clone PB217...
  8. pmc Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Malar J 10:167. 2011
    ..A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark...
  9. ncbi Nitrogen nutrition of poplar trees
    H Rennenberg
    Albert Ludwigs University Freiburg, Institute of Forest Botany and Tree Physiology, Freiburg, Germany
    Plant Biol (Stuttg) 12:275-91. 2010
    ....
  10. ncbi Cinnamon zeylanicum bark extract and powder mediated green synthesis of nano-crystalline silver particles and its bactericidal activity
    M Sathishkumar
    Environmental Biotechnology National Research Laboratory, School of Chemical Engineering, Research Institute of Industrial Technology, Chonbuk National University, Jeonju 561 756, Republic of Korea
    Colloids Surf B Biointerfaces 73:332-8. 2009
    ..72 mg/L. Thus C. zeylanicum bark extract and powder are a good bio-resource/biomaterial for the synthesis of Ag nanoparticles with antimicrobial activity...
  11. ncbi Chemical constituents of the bark of Dipteryx alata vogel, an active species against Bothrops jararacussu venom
    Pilar Puebla
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Campus Miguel de Unamuno, Salamanca University, E 37007 Salamanca, Spain
    Molecules 15:8193-204. 2010
    ..Their chemical structures were elucidated on the basis of spectroscopic analysis, including HRMS, 1D- and 2D-NMR techniques...
  12. ncbi Complex interactions among host pines and fungi vectored by an invasive bark beetle
    Min Lu
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    New Phytol 187:859-66. 2010
    ..valens and their pine hosts in China may confer advantages to these strains of L. procerum and, by extension, to the beetles themselves. These interactions may therefore enhance invasion by the beetle-fungal complex...
  13. ncbi Leaching of contaminants from untreated pine bark in a batch study: chemical analysis and ecotoxicological evaluation
    Veronica Ribé
    School of Sustainable Development of Society and Technology, Malardalen University, Box 883, SE 721 23 Västerås, Sweden
    J Hazard Mater 163:1096-100. 2009
    ..This was concluded to be related to the low pH in the eluate, since no toxicity was observed after pH adjustment before the toxicity tests...
  14. ncbi In vitro antiophidian properties of Dipteryx alata Vogel bark extracts
    Virgínia Sbrugnera Nazato
    Universidade de Sorocaba, UNISO, Rodovia Raposo Tavares, Sorocaba, SP, Brazil
    Molecules 15:5956-70. 2010
    ....
  15. ncbi A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract
    Alya Maimoona
    Department of Chemistry, Lahore College for Women University Lahore, Lahore, Pakistan alya
    J Ethnopharmacol 133:261-77. 2011
    ..Of these, two are about extraction advancement and analysis while the rest relate to its clinical, biological and nutraceutical aspects...
  16. ncbi Effect of aqueous bark extract of Garuga pinnata Roxb. in streptozotocin-nicotinamide induced type-II diabetes mellitus
    Annie Shirwaikar
    Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
    J Ethnopharmacol 107:285-90. 2006
    ..The total cholesterol and serum triglycerides levels were also significantly reduced and the HDL cholesterol levels were significantly increased upon treatment with the extract thus proving the potent antidiabetic property of the plant...
  17. ncbi In vitro antiplasmodial activity and cytotoxicity of crude extracts and compounds from the stem bark of Kigelia africana (Lam.) Benth (Bignoniaceae)
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Parasitol Res 108:1383-90. 2011
    ..These findings justify the use of K. africana stem bark as antimalaria by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new leads or natural drugs for malaria...
  18. ncbi Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica
    Sang Yoon Choi
    Korea Food Research Institute, Seongnam, Republic of Korea
    J Med Food 13:1019-23. 2010
    ..7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica...
  19. ncbi Soulamarin, a new coumarin from stem bark of Calophyllum soulattri
    Gwendoline Cheng Lian Ee
    Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Molecules 16:9721-7. 2011
    ..The structures of these compounds were established based on spectral evidence (1D and 2D NMR)...
  20. pmc A transcriptomic network underlies microstructural and physiological responses to cadmium in Populus x canescens
    Jiali He
    College of life Sciences and State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A and F University, Yangling, Shaanxi 712100, China
    Plant Physiol 162:424-39. 2013
    ..canescens bark and provide new insights into engineering woody plants for phytoremediation...
  21. ncbi No beneficial effects of pine bark extract on cardiovascular disease risk factors
    Rebecca L Drieling
    Program on Prevention Outcomes and Practices, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California 94305 5411, USA
    Arch Intern Med 170:1541-7. 2010
    ..Pine bark extract, a dietary supplement source of antioxidant oligomeric proanthocyanidin complexes, has multiple putative cardiovascular benefits. Studies published to date about the supplement have notable methodological limitations...
  22. ncbi Molecular identification and characterization of a gene associated with the onset of tapping panel dryness (TPD) syndrome in rubber tree (Hevea brasiliensis Muell.) by mRNA differential display
    Perumal Venkatachalam
    Plant Molecular Biology Lab, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
    Mol Biotechnol 41:42-52. 2009
    ..These results suggest that down-regulation of HbTOM20 in TPD-affected trees may play an important role in alteration of mitochondrial metabolism resulting in impaired latex biosynthesis...
  23. ncbi Hymenaea stigonocarpa Mart. ex Hayne: a Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models
    Patrícia Rodrigues Orsi
    Univ Estadual Paulista UNESP Departamento de Farmacologia, Instituto de Biociencias, CEP 18618 000, Botucatu, SP, Brazil
    J Ethnopharmacol 143:81-90. 2012
    ..The stem bark of this medicinal plant, popularly known as "jatobá-do-cerrado", is widely used in tea form to treat gastric pain, ulcers, diarrhoea and inflammation, whereas its fruits pulp is edible...
  24. ncbi Anti-hypertensive effects of the methanol/methylene chloride stem bark extract of Mammea africana in l-NAME-induced hypertensive rats
    P E Nguelefack-Mbuyo
    Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, BP 812 Yaounde, Cameroon
    J Ethnopharmacol 117:446-50. 2008
    ..The present study was designed to evaluate the effects of the methanol/methylene chloride from the stem bark of Mammea africana...
  25. ncbi New bioactive coumarins from Kielmeyera albopunctata
    Elita Scio
    Laboratório de Química de Produtos Naturais, CPqRR FIOCRUZ, Avenida Augusto de Lima, 1715, 30190 002, Belo Horizonte, MG, Brazil
    J Nat Prod 66:634-7. 2003
    ..Compound 1was active in vitro against the trypomastigote form of the parasite Trypanosoma cruzi, killing 80% of the parasites after 24 h contact at 4 degrees C when added at 125 microg/mL to infected murine blood...
  26. ncbi Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae)
    Walber Toma
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas, Sao Paulo, Brazil
    Biol Pharm Bull 25:1151-5. 2002
    ....
  27. ncbi Conversion of bark-rich biomass mixture into fermentable sugar by two-stage dilute acid-catalyzed hydrolysis
    Kyoung Heon Kim
    Division of Food Science, College of Life and Environmental Sciences, Korea University, Seoul 136 713, Republic of Korea
    Bioresour Technol 96:1249-55. 2005
    ..6 g of glucose (46% theoretical maximum), 10.5 g of mannose and galactose (98% theoretical maximum), and 2.8 g of xylose (85% theoretical maximum) were obtained per 100 g of the original dry feedstock...
  28. ncbi Abarema cochliacarpos: gastroprotective and ulcer-healing activities
    Maria Silene da Silva
    Campinas State University, Departamento de Anatomia, Biologia Celular e Fisiologia e Biofísica IB, CP 6109, CEP 13083 970, Campinas, SP, Brazil
    J Ethnopharmacol 132:134-42. 2010
    ..Abarema cochliacarpos (Gomes) Barneby & Grimes (Mimosaceae) is a species--in folk medicine of Lagarto city, Sergipe state, northeastern Brazil--reputed to heal gastric ulcer and gastritis...
  29. pmc Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers
    Tanja Grimm
    Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    BMC Clin Pharmacol 6:4. 2006
    ..We elucidated the plasma kinetics of genuine extract components and metabolites after single and multiple ingestion of the standardized maritime pine bark extract Pycnogenol (USP quality) by human volunteers...
  30. ncbi Antioxidant and antimicrobial effects of the mangrove tree Heritiera fomes
    Helle Wangensteen
    Department of Pharmaceutical Chemistry Pharmacognosy, School of Pharmacy, University of Oslo, P O Box 1068 Blindern, N 0316 Oslo, Norway
    Nat Prod Commun 4:371-6. 2009
    ..The bark extracts showed antibacterial activities against K. rhizophilia, S. aureus, B. subtilis and P. aeruginosa, as well. No toxicity was observed in the brine shrimp assay...
  31. ncbi Effects of harvest of nontimber forest products and ecological differences between sites on the demography of African mahogany
    Orou G Gaoue
    Botany Department, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Conserv Biol 24:605-14. 2010
    ....
  32. ncbi Antioxidant activity from the stem bark of Albizzia julibrissin
    Mee Jung Jung
    Faculty of Food Science and Biotechnology, Pukyong National University, Busan 608 737, Korea
    Arch Pharm Res 26:458-62. 2003
    ..Compound 2 showed six times stronger DPPH radical scavenging activity than L-ascorbic acid. These results show the possible antioxidant activity of the A. julibrissin crude extract and its major constituents...
  33. ncbi Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesia
    Friederike Woehrlin
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    J Agric Food Chem 58:10568-75. 2010
    ..Interestingly, a high variation was observed in one of the trees, whereas no coumarin was detected in the samples of two other trees. In conclusion, coumarin levels in cassia cinnamon can vary widely even within a single tree...
  34. ncbi Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol)
    Klaus Uhlenhut
    Institut für Pharmazie und Lebensmittelchemie, Universitat Wurzburg, 97074 Wurzburg, Germany
    Free Radic Biol Med 53:305-13. 2012
    ..In fact, intracellular accumulation of M1 could explain why in vivo bioactivity can be observed with nanomolar plasma concentrations that typically fail to exhibit measurable activity in vitro...
  35. ncbi Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens
    Jean de Dieu Tamokou
    Department of Biochemistry, Faculty of Science, University of Dschang, P O Box 67 Dschang, Cameroon
    J Ethnopharmacol 124:571-5. 2009
    ..The plant, Vismia rubescens (Guttiferae) is popularly used in Cameroon and in several parts of Africa as febrifugal and for the treatment of various microbial infections (skin diseases, diarrhoea and venereal diseases)...
  36. ncbi Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography
    Zhen dan He
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, 2 Biotechnology Avenue, Shatin, Hong Kong, China
    J Agric Food Chem 53:2424-8. 2005
    ..cassia. It is suggested that five characteristic peaks by HPLC are suitable for distinguishing genuine cassia bark from the adulterants and could be applied in the quality control of this commodity...
  37. ncbi Efficacy of Rhizophora mangle aqueous bark extract (RMABE) in the treatment of aphthous ulcers: a pilot study
    Elizabeth de Armas
    Centro Nacional de Sanidad Agropecuaria CENSA, Carretera de Jamaica y Autopista Nacional, San José de las Lajas, La Habana, Cuba
    Curr Med Res Opin 21:1711-5. 2005
    ..The present study was a randomised, single-blinded, placebo control trial conducted to asses the efficacy of RMABE in treating oral aphthous ulcers...
  38. ncbi MYC genes with differential responses to tapping, mechanical wounding, ethrel and methyl jasmonate in laticifers of rubber tree (Hevea brasiliensis Muell. Arg.)
    Yue Zhao
    Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan 571737, PR China
    J Plant Physiol 168:1649-58. 2011
    ..Characterization of HblMYC1 and HblMYC2 will contribute to the understanding of jasmonate signaling in laticifiers, a kind of specialized tissue for natural rubber biosynthesis in Hevea brasiliensis...
  39. ncbi The use of commercial saponin from Quillaja saponaria bark as a natural larvicidal agent against Aedes aegypti and Culex pipiens
    D Pelah
    The Institutes for Applied Research, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Ethnopharmacol 81:407-9. 2002
    ..The results obtained suggest that, in addition to their known activities, saponins can also serve as natural larvicidal compounds...
  40. ncbi Fire-adapted traits of Pinus arose in the fiery Cretaceous
    Tianhua He
    School of Plant Biology, University of Western Australia, Crawley, WA 6009, Australia
    New Phytol 194:751-9. 2012
    ..Our evidence for a strong correlation between the evolution of fire-response strategies and changes in fire regime 90-125 Ma greatly backdates the key role that fire has played in the evolution of seed plants...
  41. ncbi Environmental and physiological controls over oxygen and carbon isotope composition of Tasmanian blue gum, Eucalyptus globulus
    Lucas A Cernusak
    Environmental Biology Group and Cooperative Research Center for Greenhouse Accounting, Research School of Biological Sciences, Institute of Advanced Studies, Australian National University, Canberra, ACT 2601, Australia
    Tree Physiol 25:129-46. 2005
    ..globulus, 13C enrichment of sink tissues compared with source leaves does not result from an enriching process within the sink tissue...
  42. ncbi The carbon isotope composition of CO2 respired by trunks: comparison of four sampling methods
    C Damesin
    Laboratoire d Ecologie, Systématique et Evolution ESE, Universite Paris XI, CNRS UMR C8079, Batiment 362, F 91405 Orsay cedex, France
    Rapid Commun Mass Spectrom 19:369-74. 2005
    ..This study showed that, on the whole, the different sampling techniques gave similar results, but one should be aware of the variability associated with each method...
  43. ncbi Four new prenylated flavonoids and xanthones from the root bark of Artocarpus nobilis
    U L B Jayasinghe
    Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka
    Fitoterapia 79:37-41. 2008
    ..All these compounds showed strong radical scavenging properties towards DPPH radical...
  44. ncbi Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando
    Eun Kyoung Seo
    Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA
    Arch Pharm Res 26:124-7. 2003
    ..Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic...
  45. ncbi Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis
    V Kuete
    Department of Biochemistry, Yaounde University I, Yaounde, Cameroon
    Pharmazie 62:552-6. 2007
    ..The results indicate a promising basis for the use of Newbouldia laevis and some of its active principles in the treatment of infectious diseases...
  46. ncbi Inhibition of both Trypanosoma brucei bloodstream form and related glycolytic enzymes by a new kolavic acid derivative isolated from Entada abyssinica
    B Nyasse
    Laboratory of Bio Organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Cameroon
    Pharmazie 59:873-5. 2004
    ..The new derivative showed a strong and selective inhibitory activity on the GAPDH enzyme of Trypanosoma brucei with an IC50 value of 0.012 mM...
  47. ncbi Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses
    N I Pavlova
    Belarussian Research Institute for Epidemiology and Microbiology, 4 K Zetkin str, Minsk 220050, Belarus
    Fitoterapia 74:489-92. 2003
    ..All studied triterpenes were active against herpes simplex virus. Betulin and especially betulinic acid also suppressed ECHO 6 virus reproduction...
  48. ncbi Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern
    Martin Ruehl
    Department of Gastroenterology, Charite Campus Benjamin Franklin, 12200 Berlin, Germany
    J Nutr Biochem 20:597-606. 2009
    ..obtusiloba extract might be mediated by antioxidant activity. Thus, L. obtusiloba, traditionally used in Oriental medicine, may complement treatment of chronic liver disease...
  49. ncbi Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin
    Kirti Mishra
    Institute of Life Sciences, Nalco Square, Chandrasekhar Pur, Bhubaneswar 751 023, Orissa, India
    Exp Parasitol 124:421-7. 2010
    ..It was interesting to note that none of the combinations exhibited antagonistic interactions. This phenomenon offers the opportunity for further exploration of novel therapeutic concentrations and combinations...
  50. ncbi The trophic structure of bark-living oribatid mite communities analysed with stable isotopes ((15)N, (13)C) indicates strong niche differentiation
    Georgia Erdmann
    Staatliches Museum für Naturkunde Görlitz, PSF 300154, 02806 Goerlitz, Germany
    Exp Appl Acarol 41:1-10. 2007
    ..Overall, the results support the hypothesis that trophic niche differentiation of bark living oribatid mites contributes to the high diversity of the group...
  51. ncbi Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis
    Simeon F Kouam
    Department of Chemistry, Higher Teachers Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon
    J Nat Prod 69:229-33. 2006
    ..Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test...
  52. pmc Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent
    Edmund T Nartey
    Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, P, O, Box GP 4236, Accra, Ghana
    BMC Complement Altern Med 12:65. 2012
    ....
  53. ncbi Two new antimicrobial dimeric compounds: febrifuquinone, a vismione-anthraquinone coupled pigment and adamabianthrone, from two Psorospermum species
    Maurice Tsaffack
    Department of Organic Chemistry, TWAS Research Unit, Yaounde University I, Cameroon
    Chem Pharm Bull (Tokyo) 57:1113-8. 2009
    ..Their structures were determined using modern spectroscopic methods including one and two dimensional-NMR techniques as well as MS. Compounds 1 and 2 showed significant antimicrobial activities against a wide range of bacteria and fungi...
  54. ncbi Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol)
    Angelika Schäfer
    Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Biomed Pharmacother 60:5-9. 2006
    ..The next challenge is to identify the active principle(s) that are rapidly bioavailable in human plasma...
  55. ncbi A prenylated xanthone from Allanblackia floribunda
    Augustin E Nkengfack
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon
    Phytochemistry 60:381-4. 2002
    ..The 13C NMR spectral data of 1,5-dihydroxyxanthone is reported here for the first time as well as the in vitro cytotoxic activity of xanthone metabolites against the KB cell line...
  56. ncbi Implementation of the three Rs in the human hazard assessment of Brazilian medicinal plants: an evaluation of the cytotoxic and genotoxic potentials of Dipteryx alata Vogel
    Natália M Esteves-Pedro
    University of Sorocaba, UNISO, Sorocaba, SP, Brazil
    Altern Lab Anim 39:189-96. 2011
    ..The publication of such data can increase awareness of the Three Rs by showing how to optimise the management of animal use, if in vivo toxicological experiments are required...
  57. ncbi Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
    Zong Ping Zheng
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, People s Republic of China
    J Agric Food Chem 57:6649-55. 2009
    ..It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity...
  58. ncbi Simultaneous determination of cinnamaldehyde, eugenol and piperine by HPTLC densitometric method
    C L Gopu
    Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Maharashtra, Pune 411038, India
    Phytochem Anal 19:116-21. 2008
    ..The linearity was found to be in the ranges 52.54-735.56, 533.2-8531.2 and 50-300 ng/spot, respectively, with correlation coefficients of 0.9985 +/- 0.04, 0.9982 +/- 0.06 and 0.9937 +/- 0.11 for cinnamaldehyde, eugenol and piperine...
  59. ncbi In vitro activity of Tridax procumbens against promastigotes of Leishmania mexicana
    Zhelmy Martín-Quintal
    Centro de Investigación Científica de Yucatán, Merida, Yucatán CICY, Mexico
    J Ethnopharmacol 122:463-7. 2009
    ..Tridax procumbens is an active herb against leishmaniasis...
  60. ncbi Efficacy of Rhizophora mangle aqueous bark extract in the healing of open surgical wounds
    O Fernandez
    Centro Nacional de Sanidad Agropecuaria, Carretera de Jamaica y Autopista Nacional, San José de las Lajas, La Habana, Cuba
    Fitoterapia 73:564-8. 2002
    ..05) compared to the group treated with mercurocrome. No differences between the two regimes of application of the extract of R. mangle were observed. No subject showed any sign of adverse effects and no secondary infections were observed...
  61. ncbi Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines
    Marcin Drag
    Wroclaw University of Technology, Wybrzeze Wyspianskiego, Poland
    Molecules 14:1639-51. 2009
    ..Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer...
  62. ncbi Neolignans and glycosides from the stem bark of Illicium difengpi
    Lei Fang
    Key Laboratory of Bioactive Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1 Xian Nong Tan Street, Beijing 100050, People s Republic of China
    J Nat Prod 73:818-24. 2010
    ..Compounds 3, 4, and 11 exhibited moderate anti-inflammatory activities with IC(50) values ranging from 1.62 to 24.4 microM, while compound 3 displayed antioxidant activity with an IC(50) value of 42.3 microM...
  63. ncbi COX-2 and sPLA2 inhibitory activity of aqueous extract and polyphenols of Rhizophora mangle (red mangrove)
    Evangelina Marrero
    National Center for Animal and Plant Health, CENSA, Apdo 10, San José de las Lajas, La Habana, Cuba
    Fitoterapia 77:313-5. 2006
    ..The low molecular weight fraction exhibited cyclooxygenase-2 inhibitory activity while the total aqueous extract and the low molecular weight fraction showed secretory phospholipase A(2) inhibitory activity...
  64. ncbi Antioxidant activity of Rhizophora mangle bark
    Janet Sánchez
    Pharmacology and Toxicology Group, National Center of Animal and Plant Health CENSA, Carretera de Tapaste y Autopista Nacional, San José de las Lajas, La Habana, Cuba
    Fitoterapia 77:141-3. 2006
    ..The total extract and its fraction showed scavenging activity of hydroxyl radicals and hability to chelate iron ions...
  65. ncbi Antibacterial activity of Rhizophora mangle bark
    G Melchor
    Pharmacology and Toxicology Group, National Center of Animal and Plant Health CENSA, Carretera de Tapaste y Autopista Nacional, Apartado 10, San José de las Lajas, La Habana, Cuba
    Fitoterapia 72:689-91. 2001
    ..The aqueous extract of Rhizophora mangle bark, also formulated to ensure physical and chemical stability, was found to inhibit the growth of seven bacteria frequent in infected wounds...
  66. ncbi Ophiostoma species (Ascomycetes: Ophiostomatales) associated with bark beetles (Coleoptera: Scolytinae) colonizing Pinus radiata in northern Spain
    Pedro Romón
    NEIKER Tecnalia, Basque Institute for Agricultural Research and Development, Department of Plant Production and Protection, Arkaute 46 01080 Vitoria, Spain
    Can J Microbiol 53:756-67. 2007
    ..The differences in common associates among the bark beetle species could be linked to the different niches that these beetles occupy...
  67. ncbi Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury
    K Karthikeyan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, India
    Life Sci 73:2727-39. 2003
    ..The present study demonstrates that the 6.75 mg/kg TAAE augments endogenous antioxidant compounds of the rat heart and also prevents the myocardium from isoproterenol induced myocardial ischemic reperfusion injury...
  68. ncbi In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity
    C B I Alawa
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Parasitol 113:73-81. 2003
    ..senegalensis showed promising anthelmintic activity especially with use of ground whole plant materials as used by some farmers...
  69. ncbi Treatment with Alstonia scholaris enhances radiosensitivity in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Cancer Biother Radiopharm 18:917-29. 2003
    ..Our study demonstrates that ASERS treatment enhances the effect of radiation and results in disease-free survival of the mice...
  70. ncbi The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera
    G M Rukunga
    Kenya Medical Research Institute, PO Box 54840, Nairobi, Kenya
    Fitoterapia 78:455-9. 2007
    ..The alkaloids showed percentage chemosuppression of parasitaemia in mice ranging from 43 to 72%. The use of the extracts A. gummifera for treatment of malaria in traditional medicine seems to have a scientific basis...
  71. ncbi Medicinal plants used by the people of Northeast India for curing malaria
    Utpal Bora
    Department of Biotechnology, Indian Institute of Technology, Guwahati 781039, Assam, India
    Phytother Res 21:800-4. 2007
    ..In some cases the ingredients of the herbal preparation also included honey or sugar. The present investigation also indicated that most of the preparations made for curing malaria were derived from single plant sources...
  72. ncbi Antioxidant activity relates to plant part, life form and growing condition in some diabetes remedies
    Letitia M McCune
    Department of Plant Science, Macdonald Campus, McGill University, Ste Anne de Bellevue, Quebec, Canada
    J Ethnopharmacol 112:461-9. 2007
    ..The antioxidant activity of these traditional plant remedies have the potential to be partially deduced through environment signals interpreted by the traditional herbalist...
  73. ncbi Antimicrobial activity of Diospyros anisandra
    Rocio Borges-Argáez
    Centro de Investigación Científica de Yucatán, Calle 43 No 130 Chuburna, Merida, Yucatan, Mexico
    Fitoterapia 78:370-2. 2007
    ..The bioassay-guided purification of the bioactive hexane fraction resulted in the isolation and identification of the naphthoquinone plumbagin as one of the metabolites responsible for the biological activity...
  74. ncbi Leishmanicidal evaluation of extracts from native plants of the Yucatan peninsula
    S R Peraza-Sánchez
    Centro de Investigación Científica de Yucatán, Calle 41 130, Col Chuburna de Hidalgo, Merida, Yucatan, 97200 CICY, Mexico
    Fitoterapia 78:315-8. 2007
    ....
  75. ncbi Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine
    D Lirussi
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, La Plata 1900, Argentina
    Fitoterapia 75:718-23. 2004
    ..9 microg/ml, respectively. The MTT assay was made and did not show cytotoxic activity. These results allowed us to suggest that L. erythrorhizon, S. lappa, M. toosendan and C. cassia could be a source of new compounds against T. cruzi...
  76. ncbi Anti-anaemic potentials of aqueous extract of Sorghum bicolor (L.) moench stem bark in rats
    A T Oladiji
    Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
    J Ethnopharmacol 111:651-6. 2007
    ..05) in the serum catalase activity. The results revealed that extract administration has restored the anaemic condition in the iron deficient group and thus lend credence to its use in folklore medicine in the management of anaemia...
  77. ncbi Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil
    V F Andrade-Neto
    Laboratory of Malaria, Centro de Pesquisas René Rachou FIOCRUZ and Department of Parasitology, Universidade Federal de Minas Gerais UFMG, Av Augusto de Lima 1715, CEP 30190 002 MG, Belo Horizonte, Brazil
    J Ethnopharmacol 87:253-6. 2003
    ..Only Remijia ferruginea showed antimalarial activity, reducing parasitaemia and mortality at the highest dose tested. Its phytochemical analysis showed the presence of alkaloids but not quinine. The other two plant species were inactive...
  78. ncbi Interaction of some traditional plant extracts with uterine oestrogen or progestin receptors
    T Benie
    Laboratoire d Endocrinologie et de Biologie de la Reproduction, UFR Biosciences, BP 582 Abidjan 22, Cote d Ivoire
    Phytother Res 17:756-60. 2003
    ..These results suggest also that crude plant extracts may interfere with natural oestrogen and/or progestagen in vivo by binding to steroid receptors...
  79. ncbi New glycosides from Tetracentron sinense and their cytotoxic activity
    Yi Fen Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P R China
    Chem Biodivers 3:1023-30. 2006
    ..1 to 29.7 microM...
  80. ncbi Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula--a preliminary study
    Barbara Pendry
    Department of Herbal Medicine, Human and Exercise Science Academic Group, School of Health, Queensway, Enfield, Middlesex, EN3 4SA, UK
    Chem Biodivers 2:917-22. 2005
    ..1% (w/v). These results suggest that the phenolic compounds, particularly the flavonoids, may, in part, be responsible for the antioxidant activity of traditional plant extracts...
  81. ncbi Morphological, chemical and functional analysis of catuaba preparations
    Christa Kletter
    Institute of Pharmacognosy, University of Vienna, PharmaCenterVienna, Vienna, Austria
    Planta Med 70:993-1000. 2004
    ..Neither aqueous nor methanolic extracts of the Trichilia catigua reference material nor alkaloid-enriched fractions of commercial samples showed any effect on the rabbit corpus cavernosum in an in vitro test...
  82. ncbi Antimicrobial activity of some plants used for the treatment of livestock disease in the Eastern Cape, South Africa
    P J Masika
    ARDRI, University of Fort Hare, P Bag X 1314, 5700, Alice, South Africa
    J Ethnopharmacol 83:129-34. 2002
    ..Methanolic extracts exhibited higher fungal growth inhibition, whereas the water extracts showed the least inhibition. It was noteworthy that some water extracts promoted fungal growth...
  83. ncbi In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG)
    Gabino Garrido
    Laboratorio de Farmacología Centro de Química Farmacéutica, Atabey, 200 y 21 Atabey, Playa, Apartado Postal 16042 Ciudad de La Habana, Cuba
    Pharmacol Res 50:143-9. 2004
    ..7 microg ml(-1). These results represent an important contribution to the elucidation of the mechanism involved in the anti-inflammatory and anti-nociceptive effects reported by the standard M. indica extract VIMANG...
  84. ncbi Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs
    A Jain
    Department of Microbiology, King George s Medical College, Lucknow, India
    Phytomedicine 10:34-8. 2003
    ..Thus, these herbs shows anti-inflammatory activity by suppressing the capacity of P. acnes-induced ROS and pro-inflammatory cytokines, the two important inflammatory mediators in acne pathogenesis...
  85. ncbi Acaricidal activity of Uvaria versicolor and Uvaria Klaineana (Annonaceae)
    B Akendengue
    Departement de Chimie Biochimie, Faculte de Medecine et des Sciences de la Sante, B P 4009, Libreville, Gabon
    Phytother Res 17:364-7. 2003
    ..85 g/m(2)) was observed for the dichloromethane extract of Uvaria klaineana, due to the presence of benzyl benzoate. Uvaria mocoli was inactive. The structures of compounds were elucidated using 2D-NMR techniques...
  86. ncbi Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion
    Young Su Chang
    College of Pharmacy, Chosun University, Kwangju 501 759, Republic of Korea
    Phytother Res 17:426-9. 2003
    ..The most potent HIV-1 fusion inhibition was shown by the stem bark of Ailanthus altissima with 74.9 +/- 4.4% at a concentration of 100 microg/mL...
  87. ncbi Antiviral activity of simalikalactone D, a quassinoid from Quassia africana
    Sandra Apers
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 68:20-4. 2002
    ..Quassin showed no activity. For quassinoids the ester group at C-15 and the epoxymethano bridge between C-8 and C-13 appeared to be important structural features in order to exhibit a pronounced antiviral activity...
  88. ncbi Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I
    Naheed Fatima
    HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Lett 16:389-93. 2002
    ..Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I...
  89. ncbi Antibacterial activity of Pterocarpus indicus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, PMB, Lae, Papua New Guinea
    Fitoterapia 74:603-5. 2003
    ..All the fractions exhibited a wide spectrum of antibacterial activity. The activity was more pronounced in the butanol and methanol fractions. None were active against the moulds...
  90. ncbi A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice
    Ling Dong Kong
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Institute of Functional Biomolecule, Nanjing University, Nanjing 210093, People s Republic of China
    J Ethnopharmacol 93:325-30. 2004
    ....
  91. ncbi Studies on the antiplasmodial properties of some South African medicinal plants used as antimalarial remedies in Zulu folk medicine
    N Nundkumar
    Department of Biochemistry, Faculty of Science, University of Durban Westville, Durban, South Africa
    Methods Find Exp Clin Pharmacol 24:397-401. 2002
    ..Phytochemical analysis of these two active plant extracts revealed the presence of anthraquinones, flavonoids, seccoirridoids and terpenoids...
  92. ncbi Antibacterial and antifungal activities of Euroschinus papuanus
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B, Lae, Papua New Guinea
    Fitoterapia 75:412-6. 2004
    ..Excellent activity was demonstrated by the E fractions of stem heart wood, D of root bark, and E of root heart wood. Antifungal activity was exhibited by the B fractions of leaves, stem heartwood and root bark...
  93. ncbi Antibacterial, antifungal activity of Harpullia petiolaris
    M R Khan
    Department of Applied Sciences, Papua New Guinea University of Technology, P M B Lae, Papua New Guinea
    Fitoterapia 73:331-5. 2002
    ..The methanol extracts of Harpullia petiolaris, leaves, stem and root barks and heartwoods were fractionated into petrol, dichloromethane, ethyl acetate and butanol. All fractions exhibited antibacterial activity...
  94. ncbi In vitro antidrepanocytary actvity (anti-sickle cell anemia) of some congolese plants
    P T Mpiana
    Departement de Chimie, Universite de Kinshasa, Kinshasa XI, R D Congo
    Phytomedicine 14:192-5. 2007
    ....
  95. ncbi Studies of the anticancer potential of plants used in Bangladeshi folk medicine
    Letícia Veras Costa-Lotufo
    Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Fortaleza Rua Cel Nunes de Melo 1127, Caixa Postal 3157, 60430 270 Fortaleza CE, Brazil
    J Ethnopharmacol 99:21-30. 2005
    ..Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluations...
  96. ncbi Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis
    Cecília T T Blatt
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL 60612, USA
    Phytother Res 16:320-5. 2002
    ....
  97. ncbi A new diterpene from Tanaecium jaroba
    Anne Claire Mitaine-Offer
    Planta Med 68:568-9. 2002
    ..Their structures were established mainly by 1D and 2D NMR (COSY, HMQC, HMBC, ROESY) and their antiplasmodial activities were evaluated in vitro against Plasmodium falciparum...
  98. ncbi In Vitro culture studies of FlorEssence on human tumor cell lines
    Joseph Tai
    Center for Complementary Medicine Research, BC s Research Institute for Children s and Women s Health, Department of Pathology, University of British Columbia, Canada
    Phytother Res 19:107-12. 2005
    ..The results suggest that FE at high concentrations show differential inhibitory effect on different human cancer cell lines. Further studies are needed to assess the biological activities of FE...
  99. ncbi Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents
    Subhalakshmi Basu
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    Phytother Res 19:888-94. 2005
    ..madraspatana. It was noteworthy to find the MICs of emodin in the range 0.5-2.0 microg/mL against three Bacillus sp. Both the anthraquinonoid compounds inhibited P. aeruginosa, emodin being more effective, showing an MIC of 70 microg/mL...
  100. ncbi Two new anti-tumor promoting serratane-type triterpenoids from the stem bark of Picea jezoensis var. jezoensis
    Reiko Tanaka
    Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Osaka, Japan
    Planta Med 69:1041-7. 2003
    ..Compounds 1 and 2 exhibited significant anti-tumor promoting effects on mouse skin carcinogenesis...
  101. ncbi Six new triterpenoid saponins from the root and stem bark of Cephalanthus occidentalis
    Zhizhen Zhang
    Center for Medicinal Plant Research, Arthur Temple College of Forestry, Stephen F Austin State University, Nacogdoches, Texas 75962 6109, USA
    Planta Med 71:355-61. 2005
    ....

Research Grants5

  1. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  2. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  3. Flavocoxid: A Medical Food Therapy for Osteoarthritis
    Sarah Morgan; Fiscal Year: 2004
    ..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..
  4. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  5. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..