coccidioides

Summary

Summary: A mitosporic fungal genus which causes COCCIDIOIDOMYCOSIS.

Top Publications

  1. ncbi Amphotericin B and coccidioidomycosis
    Royce H Johnson
    Kern Medical Center Medicine, 1830 Flower Street, Bakersfield, CA 93305, USA
    Ann N Y Acad Sci 1111:434-41. 2007
  2. pmc Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control
    Daniel E Neafsey
    Broad Institute, Cambridge, Massachusetts 02142, USA
    Genome Res 20:938-46. 2010
  3. pmc Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis
    V Koufopanou
    Department of Plant Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:5478-82. 1997
  4. ncbi Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein
    Lisa F Shubitz
    The Valley Fever Center for Excellence, University of Arizona, Tucson, AZ 85721, USA
    Vaccine 24:5904-11. 2006
  5. ncbi The immune response in Coccidioidomycosis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, United States
    Autoimmun Rev 10:94-102. 2010
  6. ncbi Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996
    N E Rosenstein
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 32:708-15. 2001
  7. pmc The role of reactive oxygen intermediates in experimental coccidioidomycois in mice
    David A Margolis
    Veterans Affairs San Diego Healthcare System 111F 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    BMC Microbiol 11:71. 2011
  8. pmc Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis
    J Fierer
    Medical and Pathology Services, VA San Diego Healthcare System, University of California, San Diego, San Diego, California, USA
    Infect Immun 66:4397-402. 1998
  9. pmc Next-generation sequencing of Coccidioides immitis isolated during cluster investigation
    David M Engelthaler
    Translational Genomics Research Institute, Phoenix, Arizona, USA
    Emerg Infect Dis 17:227-32. 2011
  10. pmc Coccidioidomycosis: a reemerging infectious disease
    T N Kirkland
    Department of Pathology, University of California, San Diego School of Medicine, California 92161, USA
    Emerg Infect Dis 2:192-9. 1996

Detail Information

Publications204 found, 100 shown here

  1. ncbi Amphotericin B and coccidioidomycosis
    Royce H Johnson
    Kern Medical Center Medicine, 1830 Flower Street, Bakersfield, CA 93305, USA
    Ann N Y Acad Sci 1111:434-41. 2007
    ..In meningitis the intrathecal use of amphotericin B is still used frequently by some clinicians alone or with a triazole. The newer lipid preparations, while more expensive, have significantly reduced toxicity, particularly nephropathy...
  2. pmc Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control
    Daniel E Neafsey
    Broad Institute, Cambridge, Massachusetts 02142, USA
    Genome Res 20:938-46. 2010
    We have sequenced the genomes of 18 isolates of the closely related human pathogenic fungi Coccidioides immitis and Coccidioides posadasii to more clearly elucidate population genomic structure, bringing the total number of sequenced ..
  3. pmc Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis
    V Koufopanou
    Department of Plant Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 94:5478-82. 1997
    ..We have taken this approach in a study of Coccidioides immitis, an ascomycete fungus responsible for a recent epidemic of coccidioidomycosis (Valley fever) in ..
  4. ncbi Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein
    Lisa F Shubitz
    The Valley Fever Center for Excellence, University of Arizona, Tucson, AZ 85721, USA
    Vaccine 24:5904-11. 2006
    ..The chimeric antigen has the practical advantage of offering enhanced protection from multiple components without increasing production costs...
  5. ncbi The immune response in Coccidioidomycosis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, United States
    Autoimmun Rev 10:94-102. 2010
    ..and discuss not only the lymphoid response, but also recent data on antigenic analysis and bioinformatics of Coccidioides. This information is significant not only for a better understanding of Coccidiomycosis, but will also have ..
  6. ncbi Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996
    N E Rosenstein
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 32:708-15. 2001
    ..Persons at risk for severe CM may benefit from vaccination once an effective CM vaccine is available...
  7. pmc The role of reactive oxygen intermediates in experimental coccidioidomycois in mice
    David A Margolis
    Veterans Affairs San Diego Healthcare System 111F 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    BMC Microbiol 11:71. 2011
    ..In immunocompentent human beings second infections due to Coccidioides are very rare, indicating that recovery from infection results in protective immunity...
  8. pmc Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis
    J Fierer
    Medical and Pathology Services, VA San Diego Healthcare System, University of California, San Diego, San Diego, California, USA
    Infect Immun 66:4397-402. 1998
    Inbred strains of mice vary in their susceptibility to Coccidioides immitis...
  9. pmc Next-generation sequencing of Coccidioides immitis isolated during cluster investigation
    David M Engelthaler
    Translational Genomics Research Institute, Phoenix, Arizona, USA
    Emerg Infect Dis 17:227-32. 2011
    ..We used WGST to confirm the linkage of a cluster of Coccidioides immitis isolates from 3 patients who received organ transplants from a single donor who later had positive test ..
  10. pmc Coccidioidomycosis: a reemerging infectious disease
    T N Kirkland
    Department of Pathology, University of California, San Diego School of Medicine, California 92161, USA
    Emerg Infect Dis 2:192-9. 1996
    b>Coccidioides immitis, the primary pathogenic fungus that causes coccidioidomycosis, is most commonly found in the deserts of the southwestern United States and Central and South America...
  11. pmc A metalloproteinase of Coccidioides posadasii contributes to evasion of host detection
    Chiung Yu Hung
    Department of Medical Microbiology and Immunology, Medical College of Ohio, Toledo, 43614 5806, USA
    Infect Immun 73:6689-703. 2005
    b>Coccidioides posadasii is a fungal respiratory pathogen of humans that can cause disease in immunocompetent individuals. Coccidioidomycosis ranges from a mild to a severe infection...
  12. pmc Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii
    Lisa F Shubitz
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ, USA
    Infect Immun 76:5553-64. 2008
    Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species...
  13. ncbi Both CD4+ and CD8+ T cells can mediate vaccine-induced protection against Coccidioides immitis infection in mice
    Joshua Fierer
    Department of Medicine, University of California, San Diego School of Medicine, and Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Infect Dis 193:1323-31. 2006
    ..are required for vaccine-induced immunity to coccidioidomycosis, we used a temperature-sensitive mutant of Coccidioides immitis to immunize mice lacking subsets of lymphocytes or specific cytokines and infected the mice 4 weeks ..
  14. pmc Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1
    Suganya Viriyakosol
    Veterans Affairs San Diego Healthcare System 111F, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Infect Immun 73:1553-60. 2005
    b>Coccidioides posadasii is a pathogenic fungus that causes endemic and epidemic coccidioidomycosis in the deserts of North, Central, and South America. How the innate immune system responds to the organism is not well understood...
  15. pmc Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice
    J Fierer
    Department of Medicine, Veterans Administration, San Diego, California, USA
    Infect Immun 67:2916-9. 1999
    ..We found that there is also a difference in resistance to Coccidioides immitis infection among inbred mouse strains: B6 mice are susceptible, while DBA/2 mice are resistant (T. N...
  16. ncbi Point-source outbreak of coccidioidomycosis in construction workers
    K C Cummings
    Infectious Diseases Branch, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, CA, USA
    Epidemiol Infect 138:507-11. 2010
    Coccidioidomycosis results from inhaling spores of the fungus Coccidioides spp. in soil or airborne dust in endemic areas...
  17. ncbi Cloning and expression of a gene encoding a T-cell reactive protein from Coccidioides immitis: homology to 4-hydroxyphenylpyruvate dioxygenase and the mammalian F antigen
    E E Wyckoff
    Department of Botany, University of Texas, Austin, 78713, USA
    Gene 161:107-11. 1995
    The gene which encodes a previously described T-cell reactive protein (TCRP) of the human fungal pathogen Coccidioides immitis (Ci) was cloned and sequenced. Both the genomic and cDNA sequences were determined...
  18. pmc The public health impact of coccidioidomycosis in Arizona and California
    Richard F Hector
    Global Health Sciences, University of California, San Francisco, 1200 Beale St, 1200, San Francisco, CA 94105, USA
    Int J Environ Res Public Health 8:1150-73. 2011
    ..Similarly, the inability of currently available therapeutics to reduce the duration and morbidity of this disease underscores the need for improved therapeutics and a preventive vaccine...
  19. ncbi Molecular and cellular mechanisms of protective immunity to coccidioidomycosis
    Theo N Kirkland
    the Department of Pathology and Medicine, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Vaccine 24:495-500. 2006
    b>Coccidioides immitis is endemic in the soil of the desert Southwest. It causes a respiratory infection that is usually mild, but can last months and may disseminate beyond the lung...
  20. ncbi Coccidioidomycosis in patients who have undergone transplantation
    Janis E Blair
    Division of Infectious Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Ann N Y Acad Sci 1111:365-76. 2007
    ..The risk of coccidioidal infection among transplant recipients visiting in or relocating to an endemic area is low, and routine prophylaxis for this group is not recommended...
  21. pmc Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a)
    M del Pilar Jiménez-A
    Research Service, VA San Diego Healthcare, San Diego, CA 92161, USA
    Genes Immun 9:338-48. 2008
    b>Coccidioides posadasii spherules stimulate macrophages to make cytokines via TLR-2 and Dectin-1...
  22. pmc Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii
    James A Fraser
    Department of Molecular Genetics and Microbiology, 322 CARL Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 6:622-9. 2007
    ..to define the mating type locus of three dimorphic primary human fungal pathogens, Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii, using genomic analysis, direct sequencing, and bioinformatics...
  23. pmc Coccidioidomycosis as a common cause of community-acquired pneumonia
    Lisa Valdivia
    University of Arizona College of Medicine, Tucson, Arizona 85723, USA
    Emerg Infect Dis 12:958-62. 2006
    ..If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism.
  24. ncbi Phase-specific gene expression underlying morphological adaptations of the dimorphic human pathogenic fungus, Coccidioides posadasii
    H Johannesson
    Department of Evolution, Genomics and Systematics, Uppsala University, SE 752 36 Uppsala, Sweden
    Fungal Genet Biol 43:545-59. 2006
    b>Coccidioides posadasii is a dimorphic fungal pathogen that grows as a filamentous saprobe in the soil and as endosporulating spherules within the host. To identify genes specific to the pathogenic phase of Co...
  25. pmc A genetically engineered live attenuated vaccine of Coccidioides posadasii protects BALB/c mice against coccidioidomycosis
    Jianmin Xue
    Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, 78249, USA
    Infect Immun 77:3196-208. 2009
    ..United States have an elevated incidence of symptomatic infection caused by inhalation of spores of Coccidioides posadasii or Coccidioides immitis...
  26. ncbi Gene genealogies, cryptic species, and molecular evolution in the human pathogen Coccidioides immitis and relatives (Ascomycota, Onygenales)
    V Koufopanou
    Department of Plant and Microbial Biology, University of California at Berkeley, USA
    Mol Biol Evol 18:1246-58. 2001
    Previous genealogical analyses of population structure in Coccidioides immitis revealed the presence of two cryptic and sexual species in this pathogenic fungus but did not clarify their origin and relationships with respect to other taxa...
  27. ncbi Molecular cloning and expression of a cDNA encoding a Coccidioides posadasii 1,2-alpha-mannosidase identified in the coccidioidal T27K vaccine by immunoproteomic methods
    Jennine M Lunetta
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1111:164-80. 2007
    The coccidioidal T27K vaccine is protective in mice against respiratory challenge with Coccidioides posadasii (C. posadasii) arthroconidia. The vaccine is a subcellular multicomponent preparation that has not been fully characterized...
  28. pmc Urease produced by Coccidioides posadasii contributes to the virulence of this respiratory pathogen
    Fariba Mirbod-Donovan
    Department of Biology, Margaret Batts Tobin Building, Room 1 308E, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    Infect Immun 74:504-15. 2006
    Urease activity during in vitro growth in the saprobic and parasitic phases of Coccidioides spp...
  29. ncbi Profiling gene expression in Coccidioides posadasii
    N Delgado
    Department of Microbiology and Immunology Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Med Mycol 42:59-71. 2004
    b>Coccidioides posadasii is a dimorphic fungal pathogen which grows as a filamentous saprobe in the soil and multicellular parasitic form in host lung tissue...
  30. pmc Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Respir Res 5:28. 2004
    Coccidioidomycosis or Valley Fever is caused by Coccidioides in Southwest US and Central America. Primary pulmonary infection is initiated by inhalation of air-borne arthroconidia...
  31. ncbi The parasitic cell wall of Coccidioides immitis
    G T Cole
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo 43614 5806, USA
    Med Mycol 39:31-40. 2001
    b>Coccidioides immitis is a human respiratory pathogen characterized by a parasitic cycle that is unique among fungi that cause systemic mycoses. Biochemical, molecular and immunological studies of the cell wall of C...
  32. pmc Comparative transcriptomics of the saprobic and parasitic growth phases in Coccidioides spp
    Emily Whiston
    Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e41034. 2012
    b>Coccidioides immitis and C. posadasii, the causative agents of coccidioidomycosis, are dimorphic fungal pathogens, which grow as hyphae in the saprobic phase in the environment and as spherules in the parasitic phase in the mammalian host...
  33. pmc Posttransplantation disseminated coccidioidomycosis acquired from donor lungs
    Melissa B Miller
    Clinical Microbiology Immunology Laboratories, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
    J Clin Microbiol 42:2347-9. 2004
    ..The donor had previously traveled to Mexico, and the recipient had no travel history to an area where Coccidioides immitis is endemic...
  34. ncbi Global control of dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Science 312:583-8. 2006
    ..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease...
  35. ncbi IL-10 and susceptibility to Coccidioides immitis infection
    Joshua Fierer
    Trends Microbiol 14:426-7. 2006
  36. pmc Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection
    Christopher H Woelk
    Veterans Affairs San Diego Healthcare System, Mail Code 9111 F, San Diego, California 92161, USA
    BMC Microbiol 12:218. 2012
    Coccidioidomycosis results from airborne infections caused by either Coccidioides immitis or C. posadasii...
  37. ncbi Susceptibility of TLR4-defective C3H/HeJ mice to Coccidioides posadasii infection
    Shanjana Awasthi
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas, USA
    Med Mycol 48:470-5. 2010
    b>Coccidioides posadasii is one of the two fungal pathogens that cause coccidioidomycosis. The inhalation of air-borne arthroconidia leads to the formation of endospore-forming spherules in the lungs and pulmonary infection...
  38. ncbi The population biology of coccidioides: epidemiologic implications for disease outbreaks
    B M Barker
    Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    Ann N Y Acad Sci 1111:147-63. 2007
    ..isolates conducted over the past 75 years have provided a general picture of the population structure of Coccidioides, the cause of coccidioidomycosis...
  39. pmc Detection of Coccidioides antigenemia following dissociation of immune complexes
    Michelle Durkin
    MiraVista Diagnostics, Indianapolis, Indiana1 MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Vaccine Immunol 16:1453-6. 2009
    ..sensitivity for the detection of Histoplasma antigenemia, we have evaluated this method for the detection of Coccidioides antigenemia...
  40. pmc Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice
    Angel Gonzalez
    Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Microb Pathog 51:161-8. 2011
    ..In this study, we explored the role of iNOS in protection against Coccidioides infection in mice...
  41. ncbi Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods
    Raimunda S N Brilhante
    Specialized Medical Mycology Center, Federal University of Ceara, Fortaleza, Ceara, Brazil
    J Med Microbiol 57:1288-92. 2008
    Coccidioidal pericarditis is a condition found in approximately 1-5% of patients infected by Coccidioides species. It is associated with widely diverse clinical symptoms...
  42. ncbi Phenotypic characterization and ecological features of Coccidioides spp. from Northeast Brazil
    R A Cordeiro
    Medical Mycology Specialized Center, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Med Mycol 44:631-9. 2006
    This study extends phenotypic and ecological knowledge of Coccidioides spp., by describing its recovery from soils of Ceará State (Northeast Brazil) and analyzing the in vitro features of the growth of its vegetative phase...
  43. ncbi Development of a rapid, cost-effective TaqMan Real-Time PCR Assay for identification and differentiation of Coccidioides immitis and Coccidioides posadasii
    Kelly W Sheff
    Translational Genomics Research Institute, Pathogen Genomics Division TGen North, 3051 West Shamrell Boulevard, Flagstaff, Arizona, USA
    Med Mycol 48:466-9. 2010
    Coccidioidomycosis is an infection caused by Coccidioides immitis or C. posadasii. We developed a TaqMan real-time PCR assay that rapidly and accurately differentiates the species...
  44. ncbi A risk analysis for airborne pathogens with low infectious doses: application to respirator selection against Coccidioides immitis spores
    Mark Nicas
    Center for Occupational and Environmental Health, School of Public Health, University of California, Berkeley, CA 94720, USA
    Risk Anal 22:1153-63. 2002
    ..Application of the models is illustrated with a hypothetical scenario involving exposure to Coccidioides immitis, a fungus present in soil in areas of the southwestern United States Inhaling C...
  45. ncbi The utility of Coccidioides polymerase chain reaction testing in the clinical setting
    Darko Vucicevic
    Division of Infectious Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Mycopathologia 170:345-51. 2010
    Coccidioidomycosis, the fungal infection caused by dimorphic Coccidioides sp., is typically diagnosed by histopathologic identification of spherules in affected secretions and tissues or by culture...
  46. pmc SAD phasing using iodide ions in a high-throughput structural genomics environment
    Jan Abendroth
    Emerald BioStructures, 7869 NE Day Road West, Bainbridge Island, WA 98110, USA
    J Struct Funct Genomics 12:83-95. 2011
    ..These cases highlight the straightforward and powerful method of iodide ion SAD phasing in a high-throughput structural genomics environment...
  47. pmc Interleukin-12 regulation of host defenses against Coccidioides immitis
    D M Magee
    Department of Clinical Investigation, Texas Center for Infectious Diseases, San Antonio 78223, USA
    Infect Immun 64:3609-13. 1996
    ..interferon (IFN-gamma) and interleukin-4 (IL-4) in inbred mouse strains which differ in their susceptibility to Coccidioides immitis...
  48. ncbi Chapter 2: coccidioidomycosis
    Antônio de Deus Filho
    Universidade Federal do Piaui, Teresina, PI, Brasil
    J Bras Pneumol 35:920-30. 2009
    Coccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides immitis and Coccidioides posadasii. Infection is acquired by inhalation of infective arthroconidia that live in the soil...
  49. ncbi Viability and molecular authentication of Coccidioides immitis strains from culture collection of the Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    Claudia C F Bezerra
    Servico de Micologia, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brazil 4365, 21040 900 Rio de Janeiro, RJ, Brazil
    Rev Soc Bras Med Trop 39:241-4. 2006
    Twenty Coccidioides immitis strains were evaluated...
  50. ncbi In situ hybridization for Coccidioides immitis 5.8S ribosomal RNA sequences in formalin-fixed, paraffin-embedded pulmonary specimens using a locked nucleic acid probe: a rapid means for identification in tissue sections
    Kathleen T Montone
    Department of Pathology and Laboratory Medicine, Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Diagn Mol Pathol 19:99-104. 2010
    b>Coccidioides immitis/Coccidioides posadasii are common causes of pulmonary infection in certain geographic areas, and are highly infectious when working with culture isolates in the laboratory...
  51. pmc A parasitic phase-specific adhesin of Coccidioides immitis contributes to the virulence of this respiratory Fungal pathogen
    Chiung Yu Hung
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614 5086, USA
    Infect Immun 70:3443-56. 2002
    We report the isolation of a Coccidioides immitis gene (SOWgp) which encodes an immunodominant, spherule outer wall glycoprotein that is presented as a component of a parasitic phase-specific, membranous layer at the cell surface...
  52. ncbi Coccidioides niches and habitat parameters in the southwestern United States: a matter of scale
    Frederick S Fisher
    Department of Geosciences, University of Arizona, Tucson, AZ 85719, USA
    Ann N Y Acad Sci 1111:47-72. 2007
    To determine habitat attributes and processes suitable for the growth of Coccidioides, soils were collected from sites in Arizona, California, and Utah where Coccidioides is known to have been present...
  53. ncbi Expression of ornithine decarboxylase of Coccidioides immitis in three Escherichia coli strains carrying the lambda DE3 lysogen and an E. coli EWH319 strain odc- null mutant
    Miguel Angel Pantoja-Hernández
    Instituto Tecnologico de Celaya, Departamento de Ingenieráa Bioquímica, Ave Tecnológico v A Garcia Cubas, S N, Colonia FOVISSSTE, Apartado postal 57, Celaya, Guanajuato, Mexico
    Biotechnol Lett 26:75-8. 2004
    Ornithine decarboxylase from respiratory fungal pathogen, Coccidioides immitis, cloned in the pETCiODC plasmid under control of T7lac promoter, was produced in E. coli BL21(DE3), BL21(DE3)pLysS, BLR(DE3) and EWH319 transformant strains. E...
  54. pmc Evaluation of two homologous proline-rich proteins of Coccidioides posadasii as candidate vaccines against coccidioidomycosis
    Roger A Herr
    Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, Ohio 43614, USA
    Infect Immun 75:5777-87. 2007
    Evaluation of the protective efficacy of recombinant T-cell-reactive proteins of Coccidioides posadasii in a murine model of coccidioidomycosis has led to the discovery of potential vaccines against this respiratory disease...
  55. pmc Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives
    Thomas J Sharpton
    Department of Plant and Microbial Biology, University of California, Berkeley, 94720, USA
    Genome Res 19:1722-31. 2009
    While most Ascomycetes tend to associate principally with plants, the dimorphic fungi Coccidioides immitis and Coccidioides posadasii are primary pathogens of immunocompetent mammals, including humans...
  56. ncbi Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis
    Neil M Ampel
    Department of Medicine, Section of Infectious Diseases, University of Arizona, Tucson, AZ, USA
    Clin Infect Dis 48:172-8. 2009
    ..Studies that assess the value of initiating oral antifungal therapy to treat primary pulmonary coccidioidomycosis have not been published previously...
  57. pmc Cost-effectiveness of a potential vaccine for Coccidioides immitis
    A E Barnato
    University of Pittsburg, Division of General Internal Medicine, Pennsylvania 15213, USA
    Emerg Infect Dis 7:797-806. 2001
    ..We evaluated the cost- effectiveness of a potential vaccine against Coccidioides immitis. Using a decision model we developed, we estimate that among children, vaccination would saved 1...
  58. pmc Comparative efficacies of lipid-complexed amphotericin B and liposomal amphotericin B against coccidioidal meningitis in rabbits
    Karl V Clemons
    California Institute for Medical Research, San Jose, California, USA
    Antimicrob Agents Chemother 53:1858-62. 2009
    ..Male New Zealand White rabbits were infected with 5 x 10(4) Coccidioides posadasii arthroconidia by direct cisternal puncture. Therapy with intravenous ABLC or AmBi at 7...
  59. ncbi Twelve years of coccidioidomycosis in Ceará State, Northeast Brazil: epidemiologic and diagnostic aspects
    Rossana de Aguiar Cordeiro
    Specialized Medical Mycology Center, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Diagn Microbiol Infect Dis 66:65-72. 2010
    Coccidioidomycosis is an endemic infection in the Americas caused by the dimorphic fungi Coccidioides immitis and Coccidioides posadasii...
  60. pmc Epidemiologic, clinical, and diagnostic aspects of coccidioidomycosis
    Michael A Saubolle
    Laboratory Sciences of Arizona Sonora Quest Laboratories, Tempe, USA
    J Clin Microbiol 45:26-30. 2007
  61. pmc Novel approach to designing primers for identification and distinction of the human pathogenic fungi Coccidioides immitis and Coccidioides posadasii by PCR amplification
    Takashi Umeyama
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Clin Microbiol 44:1859-62. 2006
    We developed a pair of primers that specifically identifies Coccidioides species, etiologic agents of the human fungal disease coccidioidomycosis...
  62. pmc A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice
    Eric J Tarcha
    Department of Biology University of Texas at San Antonio, Margaret Batts Tobin Building, Rm 1 308E, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    Infect Immun 74:516-27. 2006
    Coccidioidomycosis is a respiratory disease of humans caused by the desert soil-borne fungal pathogens Coccidioides spp...
  63. ncbi Characteristics of the protective subcellular coccidioidal T27K vaccine
    Suzanne M Johnson
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1111:275-89. 2007
    ..This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine...
  64. pmc Coccidioidomycosis: host response and vaccine development
    Rebecca A Cox
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, Texas Research Park, 15355 Lambda Dr, San Antonio, TX 78245 3027, USA
    Clin Microbiol Rev 17:804-39, table of contents. 2004
    Coccidioidomycosis is caused by the dimorphic fungi in the genus Coccidioides. These fungi live as mycelia in the soil of desert areas of the American Southwest, and when the infectious spores, the arthroconidia, are inhaled, they convert ..
  65. pmc Multivalent recombinant protein vaccine against coccidioidomycosis
    Eric J Tarcha
    Department of Medical Microbiology and Immunology, Medical University of Ohio, Toledo, Ohio 43614, USA
    Infect Immun 74:5802-13. 2006
    ..T-cell-reactive antigens derived from the parasitic cell wall which can stimulate protective immunity against Coccidioides posadasii infection in mice...
  66. pmc Detection of Coccidioides species in clinical specimens by real-time PCR
    M J Binnicker
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Microbiol 45:173-8. 2007
    b>Coccidioides spp. are dimorphic fungal pathogens endemic to the semiarid regions of North, Central, and South America. Currently, direct smear and culture are the most common means of identifying Coccidioides spp...
  67. ncbi Combating opportunistic infections: coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Expert Opin Pharmacother 5:255-61. 2004
    ..Intrathecal amphotericin B is required for those cases that fail. Prevention of coccidioidomycosis by environmental control is difficult. In the future, immunisation or immune modulation may offer protection...
  68. pmc Amplification of coccidioidal DNA in clinical specimens by PCR
    Suzanne M Johnson
    Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California 95616, USA
    J Clin Microbiol 42:1982-5. 2004
    b>Coccidioides DNA was amplified from serum by a PCR using coccidioid-specific primers. A 239-bp product was visualized when 10 fg of exogenous coccidioidal DNA was subjected to amplification...
  69. ncbi Genetic diversity among clinical Coccidioides spp. isolates in Arizona
    Kelsea Jewell
    Arizona Department of Health Services, Phoenix, Arizona, USA
    Med Mycol 46:449-55. 2008
    ..One hundred and twenty-one clinical Coccidioides spp. isolates were collected over 16 months from Maricopa, Graham, Yuma, and Pima counties in Arizona...
  70. pmc A recombinant beta-1,3-glucanosyltransferase homolog of Coccidioides posadasii protects mice against coccidioidomycosis
    Nelson Delgado
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo 43614, USA
    Infect Immun 71:3010-9. 2003
    b>Coccidioides posadasii is a fungal respiratory pathogen which is responsible for recurrent epidemics of San Joaquin Valley fever (coccidioidomycosis) in desert regions of the southwestern United States...
  71. ncbi Seeking a vaccine against Coccidioides immitis and serologic studies: expectations and realities
    D Pappagianis
    School of Medicine, University of California, Davis, California 95616, USA
    Fungal Genet Biol 32:1-9. 2001
    ..Concurrent conduct of the two approaches should maximize the chances for success...
  72. ncbi Identification of a protective antigen of Coccidioides immitis by expression library immunization
    F Douglas Ivey
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Vaccine 21:4359-67. 2003
    b>Coccidioides immitis is a fungal pathogen of humans and is classified as a Select Agent. We have identified a new potential vaccine candidate for this pathogen using cDNA expression library immunization (ELI). A C...
  73. ncbi Coccidioidomycosis in patients with HIV-1 infection in the era of potent antiretroviral therapy
    Fares Y Masannat
    Division of Infectious Diseases, Department of Medicine, and Valley Fever Center for Excellence, University of Arizona, and Southern Arizona Veterans Affairs Health Care System, Tucson, USA
    Clin Infect Dis 50:1-7. 2010
    ..However, there have been no studies on its incidence or clinical expression during the era of potent antiretroviral therapy...
  74. ncbi Coccidioides fungemia in six patients, with a review of the literature
    David W Keckich
    Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mycopathologia 170:107-15. 2010
    To identify demographics, clinical manifestations, and outcomes of patients with Coccidioides fungemia, we searched our institutional medical records to identify patients with Coccidioides fungemia treated between 1998 and 2008 and ..
  75. ncbi Efficacy of antigen 2/proline-rich antigen cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasii
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 175:3900-6. 2005
    b>Coccidioides posadasii causes coccidioidomycosis, or Valley fever, in the endemic regions of the Southwestern United States. The susceptibility to C. posadasii infection has been attributed to a decreased Th1 cellular response...
  76. ncbi Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosis
    John O Richards
    Department of Microbiology and Immunology, Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Immunol 169:2020-5. 2002
    b>Coccidioides immitis is a pathogenic, dimorphic fungus found in the southwestern United States and is the causative agent of coccidioidomycosis...
  77. ncbi Dendritic cells pulsed with Coccidioides immitis lysate induce antigen-specific naive T cell activation
    J O Richards
    Department of Microbiology and Immunology, University of Arizona, Tucson, AZ 85724, USA
    J Infect Dis 184:1220-4. 2001
    Coccidioidomycosis, an infection endemic to the southwestern United States, is caused by the fungus Coccidioides immitis. Coccidioidal infection is overcome by the development of cell-mediated immunity...
  78. pmc Coccidioidal pneumonia, Phoenix, Arizona, USA, 2000-2004
    Michelle M Kim
    Mayo Clinic, Scottsdale, Arizona 85259, USA
    Emerg Infect Dis 15:397-401. 2009
    ..In large, geographically defined areas where Coccidioides spp...
  79. ncbi The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism
    Kara Bortone
    Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    J Mol Biol 320:293-302. 2002
    ..We show that allosamidin is a competitive inhibitor of the fungal chitinase CiX1 from Coccidioides immitis, with a K(i) of 60 nM...
  80. ncbi Coccidioides posadasii contains single chitin synthase genes corresponding to classes I to VII
    M Alejandra Mandel
    Department of Plant Sciences, Division of Plant Pathology and Microbiology, University of Arizona, Tucson, AZ 85721 0036, USA
    Fungal Genet Biol 43:775-88. 2006
    b>Coccidioides posadasii is a dimorphic fungal pathogen of humans and other mammals. The switch between saprobic and parasitic growth involves synthesis of new cell walls of which chitin is a significant component...
  81. pmc Protein expression profiling of Coccidioides posadasii by two-dimensional differential in-gel electrophoresis and evaluation of a newly recognized peroxisomal matrix protein as a recombinant vaccine candidate
    Kris I Orsborn
    Valley Fever Center for Excellence 1 111 INF, 3601 S 6th Ave, University of Arizona, Tucson, AZ 85723, USA
    Infect Immun 74:1865-72. 2006
    b>Coccidioides posadasii and Coccidioides immitis are dimorphic, soil-dwelling pathogenic ascomycetes endemic to the southwestern United States...
  82. pmc Biogeographic range expansion into South America by Coccidioides immitis mirrors New World patterns of human migration
    M C Fisher
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 98:4558-62. 2001
    ..Herein, we use microsatellite loci from the human pathogen Coccidioides immitis to show that genetic diversity in this fungus is geographically partitioned throughout North America...
  83. ncbi Kinetic properties of chitinase-1 from the fungal pathogen Coccidioides immitis
    T Fukamizo
    Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    Biochemistry 40:2448-54. 2001
    The endochitinase from Coccidioides immitis (CiX1) is a member of the class 18 chitinase family...
  84. ncbi A test for concordance between the multilocus genealogies of genes and microsatellites in the pathogenic fungus Coccidioides immitis
    M C Fisher
    Department of Plant and Microbial Biology, University of California at Berkeley Roche Molecular Systems, Alameda, California 94720 3102, USA
    Mol Biol Evol 17:1164-74. 2000
    ..Seven microsatellites from the pathogenic fungus Coccidioides immitis were sequenced for 20 clinical isolates chosen to represent the known genetic diversity of the pathogen...
  85. pmc Pathogenic clones versus environmentally driven population increase: analysis of an epidemic of the human fungal pathogen Coccidioides immitis
    M C Fisher
    Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720, USA
    J Clin Microbiol 38:807-13. 2000
    ..A major epidemic of coccidioidomycosis (etiologic agent, Coccidioides immitis) occurred between 1991 and 1994 in central California, representing an 11-fold increase above the mean ..
  86. pmc Concerted evolution in the repeats of an immunomodulating cell surface protein, SOWgp, of the human pathogenic fungi Coccidioides immitis and C. posadasii
    Hanna Johannesson
    Department of Evolution, Genomics and Systematics, Evolutionary Biology Centre, Uppsala University, Sweden
    Genetics 171:109-17. 2005
    ..This gene, SOWgp, encodes the immunodominant protein in the parasitic phase of the human pathogenic fungi Coccidioides immitis and C. posadasii...
  87. ncbi Coccidioides species as potential agents of bioterrorism
    David W Warnock
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Future Microbiol 2:277-83. 2007
    b>Coccidioides species are soil fungi endemic to the southwestern USA, and parts of Central and South America. Natural infection occurs as a result of inhalation of airborne arthroconidia...
  88. ncbi Coccidioidomycosis
    Tom M Chiller
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Infect Dis Clin North Am 17:41-57, viii. 2003
    b>Coccidioides, a fungus, is endemic to specific parts of the Western Hemisphere. This article examines the prevalence, pathogenesis and host defense, clinical manifestations, diagnosis, and treatment of coccidioidomycosis.
  89. ncbi Virulence mechanisms of coccidioides
    Chiung Yu Hung
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 0662, USA
    Ann N Y Acad Sci 1111:225-35. 2007
    b>Coccidioides is a fungal respiratory pathogen of humans that can cause disease in both immunosuppressed and immunocompetent individuals...
  90. pmc Genomic and population analyses of the mating type loci in Coccidioides species reveal evidence for sexual reproduction and gene acquisition
    M Alejandra Mandel
    Division of Plant Pathology and Microbiology, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Eukaryot Cell 6:1189-99. 2007
    b>Coccidioides species, the fungi responsible for the valley fever disease, are known to reproduce asexually through the production of arthroconidia that are the infectious propagules...
  91. ncbi Nuclear labeling of Coccidioides posadasii with green fluorescent protein
    Lei Li
    Department of Plant Sciences, Forbes Bldg, Room 303, 1140 E South Campus Dr, P O Box 210036, Tucson, AZ 85721, USA
    Ann N Y Acad Sci 1111:198-207. 2007
    ..is a mild to life-threatening disease in otherwise healthy humans and other mammals caused by the fungus Coccidioides spp. Understanding the development of the unique dimorphic life cycle of Coccidioides spp...
  92. ncbi Significance of isolated positive IgM serologic results by enzyme immunoassay for coccidioidomycosis
    Janis E Blair
    Division of Infectious Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA
    Mycopathologia 166:77-82. 2008
    ..No false-positive IgM assays were observed. We conclude that the false-positive rate of the EIA IgM is low, and that an isolated positive EIA IgM should prompt further follow-up and diagnostic testing...
  93. ncbi Expanding understanding of epidemiology of coccidioidomycosis in the Western hemisphere
    Rafael Laniado-Laborin
    M P H, F C C P, Facultad de Medicina Tijuana, Universidad Autónoma de Baja, P O Box 436338, San Ysidro, CA 92143 6338, USA
    Ann N Y Acad Sci 1111:19-34. 2007
    ..The endemic region for Coccidioides spp. lies exclusively in the Western Hemisphere. Coccidioides spp...
  94. pmc Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts
    Janis E Blair
    Division of Infectious Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, Arizona, AZ 85259, USA
    Mycopathologia 162:317-24. 2006
    ..Immunosuppressed persons have the ability to mount a serologic response to coccidioidomycosis, but in some circumstances, multiple methods may be required to improve detection...
  95. ncbi Positive directional selection in the proline-rich antigen (PRA) gene among the human pathogenic fungi Coccidioides immitis, C. posadasii and their closest relatives
    Hanna Johannesson
    Department of Plant and Microbial Biology, University of California, Berkeley, USA
    Mol Biol Evol 21:1134-45. 2004
    ..of selection acting on the proline-rich antigen (PRA) gene in natural populations of the two human pathogens, Coccidioides immitis and Coccidioides posadasii, and three of their close relatives, Chrysosporium lucknowense, ..
  96. ncbi Dendritic cell-based vaccine against coccidioides infection
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA
    Ann N Y Acad Sci 1111:269-74. 2007
    b>Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease...
  97. ncbi Molecular approaches to the study of Coccidioides immitis
    Raed O Abuodeh
    University of Sharjah, College of Health Sciences, Sharjah, United Arab Emirates
    Int J Med Microbiol 292:373-80. 2002
    The study of the molecular biology of Coccidioides sp. is only just beginning...
  98. ncbi Coccidioidomycosis in the U.S. Military: a review
    Nancy F Crum-Cianflone
    Clinical Investigation Department KCA, Naval Medical Center San Diego, 34800 Bob Wilson Drive, Ste 5, San Diego, CA 92134 1005, USA
    Ann N Y Acad Sci 1111:112-21. 2007
    Coccidioidomycosis has had an impact on the military since the discovery of the causative agent, Coccidioides immitis, over a century ago. The first reports of Coccidioides outbreaks affecting U.S...
  99. ncbi Taxonomic and diagnostic markers for identification of Coccidioides immitis and Coccidioides posadasii
    K Tintelnot
    Robert Koch Institut, Berlin, Germany
    Med Mycol 45:385-93. 2007
    The ribosomal Internal Transcribed Spacer (ITS) regions of the two recognized species of Coccidioides were studied using a reference set of strains that had been previously identified with species defining microsatellite polymorphisms...
  100. ncbi [Coccidioidomycosis: an imported invasive fungal disease in France]
    M O Chandesris
    Service des Maladies Infectieuses et Tropicales, Faculte de Medecine, Paris 5, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex, France
    Med Mal Infect 38:336-42. 2008
    ..The final identification of Coccidioides immitis was made by molecular analysis...
  101. ncbi Therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate for coccidioidomycosis in a mouse model
    Gloria M Gonzalez
    Departamento de Microbiologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon 64460, Mexico
    J Antimicrob Chemother 60:1341-6. 2007
    ..The therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate was evaluated in treatment of murine coccidioidomycosis...

Research Grants35

  1. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..dermatitidis as well as related dimorphic fungi Coccidioides posadasii and Histoplasma capsulatum...
  2. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..hypothesize that Ag-specific CD4+ T cells that protect against dimorphic fungi - Blastomyces, Histoplasma, and Coccidioides - enter the memory pool and retain the ability long-term to produce IL-17 on re-exposure to the pathogen...
  3. A Recombinant Protein Vaccine Against Coccidioidomycosis
    GARRY THOMAS COLE; Fiscal Year: 2012
    b>Coccidioides is an airborne fungal pathogen that can cause mild to severe respiratory disease (coccidioidomycosis;San Joaquin Valley fever) in immunocompetent individuals. The fungus inhabits desert soil in the Southwestern U.S...
  4. Gene Circuits that Control Morphology in Histoplasma
    Anita Sil; Fiscal Year: 2013
    ..capsulatum as well as select agent pathogens such as Coccidioides species...
  5. Broad spectrum therapeutics targeting resolvase enzymes
    Frederic D Bushman; Fiscal Year: 2010
    ..enzyme is also important in pathogenic fungi such as Coccidioldes, the causative Coccidioides, Fever, where agent of Valley Fever, where it is involved in mitochondrial DNA replication...
  6. Antigen Immunoassay for Diagnosis of Coccidioidomycosis
    Sean Bauman; Fiscal Year: 2013
    ..provided by applicant): Coccidioidomycosis, also known as "Valley Fever," is a fungal disease caused by Coccidioides spp. that infects an estimated 150,000 people each year in the United States...
  7. Optimized CYP51 Inhibitors for the Oral Treatment of CNS Coccidioides Infections
    Edward P Garvey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coccidioides immitis and C. posadasii, fungi endemic to the southwest United States, are regarded as potential bioterrorist weapons. Coccidioidomycosis results from inhalation of fungal spores...
  8. Molecular Detection of Invasive Fungal Infections
    ANDREW E LEVIN; Fiscal Year: 2013
    ..capsulatum, Fusarium spp, Zygomycetes, Cryptococcus spp, and Coccidioides spp...
  9. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..Nikkomycin Z is a chitin synthase inhibitor with its greatest in vitro activity against Coccidioides. It is very effective as oral experimental therapy in mice with coccidioidomycosis...
  10. PARACOCCIDIOIDOMYCOSIS--EVOLUTION AND STRAIN-TYPING
    John Taylor; Fiscal Year: 2002
    ..1) Fungal species concepts are morphological, but our experience with Histoplasma capsulatum, Coccidioides immitis and Aspergillus flavus shows that a morphological species can harbor more than one genetically isolated ..
  11. A novel yeast vaccine against Coccidioides Immitis
    Claude Selitrennikoff; Fiscal Year: 2003
    Coccidioidomycosis, also known as San Joaquin Valley Fever, is a fungal disease caused by Coccidioides immitis that is endemic in portions of Southern Arizona, central California, southern New Mexico and west Texas...
  12. IMMUNOREACTIVE MACROMOLECULES OF COCCIDIOIDES CELL TYPES
    Garry Cole; Fiscal Year: 2001
    ..Our overall goals are to characterize specific antigens of C. immitis which elicit humoral and cellular immune responses in the hopes of improving diagnostic reagents, and eventually developing a vaccine against coccidioidomycosis. ..
  13. MOLECULAR STRATEGIES TOWARDS A COCCIDIOIDOMYCOSIS VACCIN
    Theo Kirkland; Fiscal Year: 2003
    ..These results provide proof of concept that an effective vaccine for Coccidioides immitis is a realistic goal. The program consists of five projects...
  14. Experimental Pharmacology and Chemical Studies of Nikkomycin Z
    John N Galgiani; Fiscal Year: 2010
    ..Infection with Coccidioides spp...
  15. LC-Tandem Mass Spectrometer
    Robert Blumenthal; Fiscal Year: 2004
    ..of the eight major users include characterization of the fungal pathogen and potential bioterrorism agent Coccidioides immitis, the link between reactive oxygen species-dependent inactivation of Na + ATPase and pathological ..
  16. Coccidiodes immitis Genome Sequencing Project
    Malcolm Gardner; Fiscal Year: 2002
    b>Coccidioides immitis is a fungal pathogen of humans that causes a respiratory disease called Valley Fever...
  17. IMMUNOREACTIVE MACROMOLECULES OF COCCIDIOIDES CELL TYPES
    Garry Cole; Fiscal Year: 2006
    ..A correlation exists between resistance/susceptibility to Coccidioides immitis infection and the profile of cytokine response elicited in mice...
  18. Genomic-based diagnostics for Coccidioides the causative agent of Valley fever
    PAUL STEPHEN KEIM; Fiscal Year: 2010
    ..Program Director/Principal Investigator (Last, First, Middle): Keim, Paul 1 R01 AI076773-01 No Text ..
  19. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  20. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  21. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  22. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  23. Cryptococcus gatti mating 1oci; mapping and gene study
    Vishnu Chaturvedi; Fiscal Year: 2004
    ..abstract_text> ..
  24. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  25. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  26. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  27. Host-Response Relationships in Patients with Candidemia
    Melissa Johnson; Fiscal Year: 2006
    ....
  28. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    ..abstract_text> ..
  29. Clinical Suspicion of TB: A Technology Assessment Tool
    Antonino Catanzaro; Fiscal Year: 2007
    ..It will help define the role of serologic testing in the diagnosis of PTB. ..
  30. Host control in Coccidioidomycosis
    John Galgiani; Fiscal Year: 2008
    ..It poses problems for the military and Coccidioides spp. are a potential threat to homeland security. Current therapies are inadequate...
  31. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  32. Nikkomycin Z Treatment for Coccidioidomycosis
    John Galgiani; Fiscal Year: 2006
    ..b>Coccidioides species are CDC select agents and in the past have been agents developed for bio-warfare...