candida albicans

Summary

Summary: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).

Top Publications

  1. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
  2. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011
  3. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
  4. ncbi An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
  5. pmc A recently evolved transcriptional network controls biofilm development in Candida albicans
    Clarissa J Nobile
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94102, USA
    Cell 148:126-38. 2012
  6. pmc Candida albicans morphogenesis and host defence: discriminating invasion from colonization
    Neil A R Gow
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nat Rev Microbiol 10:112-22. 2012
  7. pmc Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans
    Constantin F Urban
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Pathog 5:e1000639. 2009
  8. pmc Hsp90 governs dispersion and drug resistance of fungal biofilms
    Nicole Robbins
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 7:e1002257. 2011
  9. pmc A phenotypic profile of the Candida albicans regulatory network
    Oliver R Homann
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000783. 2009
  10. pmc Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France
    Science 332:65-8. 2011

Research Grants

  1. Candida albicans oral biofilm
    WELDA CHAFFIN; Fiscal Year: 2004
  2. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
  3. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
  4. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
  5. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
  6. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
  7. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
  8. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
  9. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
  10. Centromere Structure and Function in Candida albicans
    Judith G Berman; Fiscal Year: 2012

Detail Information

Publications338 found, 100 shown here

  1. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    b>Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection of virulence mechanisms...
  2. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011
    The fungus Candida albicans is often a benign member of the mucosal flora; however, it commonly causes mucosal disease with substantial morbidity and in vulnerable patients it causes life-threatening bloodstream infections...
  3. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
    b>Candida albicans and Saccharomyces cerevisiae switch from a yeast to a filamentous form. In Saccharomyces, this switch is controlled by two regulatory proteins, Ste12p and Phd1p...
  4. ncbi An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
    ..In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading ..
  5. pmc A recently evolved transcriptional network controls biofilm development in Candida albicans
    Clarissa J Nobile
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94102, USA
    Cell 148:126-38. 2012
    ..we describe and analyze the transcriptional network controlling biofilm formation in the pathogenic yeast Candida albicans, whose biofilms are a major source of medical device-associated infections...
  6. pmc Candida albicans morphogenesis and host defence: discriminating invasion from colonization
    Neil A R Gow
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nat Rev Microbiol 10:112-22. 2012
    b>Candida albicans is a common fungal pathogen of humans that colonizes the skin and mucosal surfaces of most healthy individuals...
  7. pmc Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans
    Constantin F Urban
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Pathog 5:e1000639. 2009
    ..Analysis of three different Candida albicans in vivo infection models indicated that NET formation is a hitherto unrecognized route of calprotectin ..
  8. pmc Hsp90 governs dispersion and drug resistance of fungal biofilms
    Nicole Robbins
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 7:e1002257. 2011
    ..We previously established that in the leading human fungal pathogen, Candida albicans, Hsp90 enables the emergence and maintenance of drug resistance in planktonic conditions by stabilizing the ..
  9. pmc A phenotypic profile of the Candida albicans regulatory network
    Oliver R Homann
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000783. 2009
    b>Candida albicans is a normal resident of the gastrointestinal tract and also the most prevalent fungal pathogen of humans. It last shared a common ancestor with the model yeast Saccharomyces cerevisiae over 300 million years ago...
  10. pmc Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France
    Science 332:65-8. 2011
    ..by recurrent or persistent infections of the skin, nails, and oral and genital mucosae caused by Candida albicans and, to a lesser extent, Staphylococcus aureus, in patients with no other infectious or autoimmune ..
  11. pmc Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq
    Vincent M Bruno
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genome Res 20:1451-8. 2010
    b>Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections that are often lifethreatening...
  12. pmc From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells
    Betty Wächtler
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena, Jena, Germany
    PLoS ONE 6:e17046. 2011
    b>Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by penetrating through epithelial barriers. C...
  13. ncbi Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
    ..1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans...
  14. pmc Biofilm matrix regulation by Candida albicans Zap1
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, United States of America
    PLoS Biol 7:e1000133. 2009
    ..This report focuses on the biofilm matrix of Candida albicans, the major fungal pathogen of humans. We report here that the C...
  15. ncbi Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    Leah E Cowen
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 309:2185-9. 2005
    ..During selection in a human host, drug resistance that was initially Hsp90-dependent evolved toward independence. Thus, Hsp90 can act in diverse ways to couple environmental contingency to the emergence and fixation of new traits...
  16. ncbi Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
    Constantin F Urban
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Cell Microbiol 8:668-76. 2006
    ..Here we show for the first time that Candida albicans, a eukaryotic pathogen, induces NET-formation and is susceptible to NET-mediated killing. C...
  17. pmc The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
    Diane O Inglis
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D667-74. 2012
    ..sequence data and manually curated functional information about genes and proteins of the fungal pathogen Candida albicans and other Candida species...
  18. pmc A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Biol Chem 285:12087-95. 2010
    ..The Candida albicans MNT1/KRE2 mannosyl transferase family is represented by five members...
  19. pmc PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
    Shantelle L LaFayette
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 6:e1001069. 2010
    ..of the model yeast Saccharomyces cerevisiae and a clinical isolate of the leading human fungal pathogen Candida albicans were inhibitors of protein kinase C (PKC), which regulates cell wall integrity during growth, morphogenesis, ..
  20. pmc Genetic control of Candida albicans biofilm development
    Jonathan S Finkel
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Microbiol 9:109-18. 2011
    ..mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity...
  21. ncbi A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Mol Biol 337:243-53. 2004
    ..Lists of potentially GPI lipid anchored proteins for five fungal proteomes have been generated and the hits have been functionally classified. The fungal big-Pi prediction WWW server as well as precursor lists are available at..
  22. pmc Contribution of Candida albicans cell wall components to recognition by and escape from murine macrophages
    C G J McKenzie
    College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 78:1650-8. 2010
    The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to escape destruction by the host immune system...
  23. pmc The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation
    Brian B Tuch
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 6:e1001070. 2010
    ..White and opaque cells of the fungal pathogen Candida albicans are two such heritable cell types, each thought to be adapted to unique niches within their human host...
  24. pmc An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Host Microbe 5:487-97. 2009
    b>Candida albicans is an opportunistic fungal pathogen causing life-threatening mucosal and systemic infections in immunocompromised humans...
  25. pmc Portrait of Candida albicans adherence regulators
    Jonathan S Finkel
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 8:e1002525. 2012
    ..Our study focuses on adherence of the fungal pathogen Candida albicans to one substrate, silicone, that is relevant to device-associated infection...
  26. pmc Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target
    Guanpingsheng Luo
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
    J Infect Dis 201:1718-28. 2010
    b>Candida albicans is the most common cause of invasive fungal infections in humans. It is unclear how C. albicans escapes from phagocytic attack and survives in the hostile blood environment during life-threatening systemic infections...
  27. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
    The opportunistic fungal pathogen Candida albicans is both a benign gut commensal and a frequently fatal systemic pathogen. The interaction of C...
  28. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
    The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of beta-glucans and chitin...
  29. pmc Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Bacteriol 183:5385-94. 2001
    ..Using two clinically relevant Candida albicans biofilm models formed on bioprosthetic materials, we demonstrated that biofilm formation proceeds through ..
  30. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms...
  31. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
    ..However, some commensal-pathogenic microorganisms, such as the yeast Candida albicans, thrive in both environments. We report the evolution of a transcription circuit in C...
  32. pmc Interactions of Candida albicans with epithelial cells
    Weidong Zhu
    Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Cell Microbiol 12:273-82. 2010
    The fungus, Candida albicans, interacts with epithelial cells in the human host both as a normal commensal and as an invasive pathogen. It has evolved multiple complementary mechanisms to adhere to epithelial cells. Adherent C...
  33. pmc Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    Rebecca S Shapiro
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Curr Biol 19:621-9. 2009
    ..Here we demonstrate that in the leading fungal pathogen of humans, Candida albicans, Hsp90 governs cellular circuitry required not only for drug resistance but also for the key morphogenetic ..
  34. pmc Recognition and blocking of innate immunity cells by Candida albicans chitin
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 79:1961-70. 2011
    ..We show here that ultrapurified chitin from Candida albicans cell walls did not stimulate cytokine production directly but blocked the recognition of C...
  35. ncbi Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108 8639, Japan
    Immunity 32:681-91. 2010
    ..Here, we generated Clec4n(-/-) mice and showed that this molecule is important for host defense against Candida albicans (C. albicans). Clec4n(-/-) DCs had virtually no fungal alpha-mannan-induced cytokine production...
  36. ncbi Virulence factors of Candida albicans
    R A Calderone
    Dept of Microbiology and Immunology, Georgetown University Medical Center, 20007, Washington, DC, USA
    Trends Microbiol 9:327-35. 2001
    ..who are immunocompromised or debilitated in some other way, the organism most often responsible for disease, Candida albicans, expresses several virulence factors that contribute to pathogenesis...
  37. ncbi Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections
    Ronny Martin
    Center for Innovation Competence Septomics, Research Group Fungal Septomics at the Leibniz Institute for Natural Products Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
    Int J Med Microbiol 301:417-22. 2011
    Oral infections with Candida albicans are very common diseases in even only mildly immunocompromised patients...
  38. ncbi Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    B R Braun
    Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 277:105-9. 1997
    The pathogenic yeast Candida albicans regulates its cellular morphology in response to environmental conditions...
  39. pmc New tools at the Candida Genome Database: biochemical pathways and full-text literature search
    Marek S Skrzypek
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 38:D428-32. 2010
    ..sequence data and manually curated functional information about genes and proteins of the human pathogen Candida albicans. Herein, we describe two recently added features, Candida Biochemical Pathways and the Textpresso full-text ..
  40. pmc Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    Sheena D Singh
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 5:e1000532. 2009
    b>Candida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals...
  41. ncbi Cross-kingdom interactions: Candida albicans and bacteria
    Mark E Shirtliff
    Department of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 299:1-8. 2009
    ..However, reports describing a multitude of wide-ranging interactions between the fungal pathogen Candida albicans and various bacterial pathogens are on the rise...
  42. pmc Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance
    Yang Lu
    Department of Biological Chemistry, University of California, Irvine, California, United States of America
    PLoS Biol 9:e1001105. 2011
    Phenotypic plasticity is common in development. For Candida albicans, the most common cause of invasive fungal infections in humans, morphological plasticity is its defining feature and is critical for its pathogenesis...
  43. pmc Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation
    Jeniel E Nett
    University of Wisconsin, Department of Medicine, Madison, WI 53705, USA
    Eukaryot Cell 10:1660-9. 2011
    b>Candida albicans frequently infects medical devices by growing as a biofilm, i.e., a community of adherent organisms entrenched in an extracellular matrix. During biofilm growth, Candida spp...
  44. pmc A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
    David L Moyes
    Department of Oral Medicine, Pathology, and Immunology, King s College London Dental Institute, King s College London, London, UK
    Cell Host Microbe 8:225-35. 2010
    ..The opportunistic human fungal pathogen Candida albicans is also a constituent of the normal oral flora and grows either as yeasts or hyphae...
  45. pmc Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    Stephen P Saville
    Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Eukaryot Cell 2:1053-60. 2003
    It is widely assumed that the ability of Candida albicans to switch between different morphologies is required for pathogenesis...
  46. pmc Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, Quebec, H4P 2R2, Canada
    Genome Biol 11:R71. 2010
    Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation.
  47. pmc CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:422-34. 2011
    ..During an oral Candida albicans infection in mice, Treg cells induced IL-17 cytokines in Tresp cells, which markedly enhanced fungal ..
  48. ncbi Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes
    Frederic Dalle
    Robert Koch Institute, Nordufer 20, Berlin, Germany
    Cell Microbiol 12:248-71. 2010
    The human pathogenic fungus Candida albicans can cause systemic infections by invading epithelial barriers to gain access to the bloodstream. One of the main reservoirs of C...
  49. pmc An extensive circuitry for cell wall regulation in Candida albicans
    Jill R Blankenship
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    PLoS Pathog 6:e1000752. 2010
    ..Protein kinases play key roles in signaling and response to changes in the external environment. The ability of Candida albicans to quickly sense and respond to changes in its environment is key to its survival in the human host...
  50. pmc Evolutionary tinkering with conserved components of a transcriptional regulatory network
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    PLoS Biol 8:e1000329. 2010
    ....
  51. pmc Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis
    David Kadosh
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Mol Biol Cell 16:2903-12. 2005
    b>Candida albicans, the major human fungal pathogen, undergoes a reversible morphological transition from blastospores (round budding cells) to filaments (elongated cells attached end-to-end)...
  52. ncbi An improved transformation protocol for the human fungal pathogen Candida albicans
    Andrea Walther
    Junior Research Group Growth control of Fungal Pathogens, Hans Knöll Institut für Naturstoff Forschung, Friedrich Schiller University, Winzerlaer Strasse 10, 07745, Jena, Germany
    Curr Genet 42:339-43. 2003
    Commonly used protocols for the transformation of the dimorphic human fungal pathogen Candida albicans rely on established methods for the yeast Saccharomyces cerevisiae...
  53. pmc Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition
    Andre Nantel
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Mol Biol Cell 13:3452-65. 2002
    The ability of the pathogenic fungus Candida albicans to switch from a yeast to a hyphal morphology in response to external signals is implicated in its pathogenicity...
  54. pmc APSES proteins regulate morphogenesis and metabolism in Candida albicans
    Thomas Doedt
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 15:3167-80. 2004
    ..The human fungal pathogen Candida albicans contains two APSES proteins: the regulator Efg1p and its homologue Efh1p, described here...
  55. pmc Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, NY, USA
    Cell Microbiol 10:2180-96. 2008
    ..We have focused on Rim101 from Candida albicans, which we find to be required for virulence in an oropharyngeal candidiasis model...
  56. ncbi Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Memory T cells specific for Candida albicans were present mainly in the CCR6+CCR4+ T(H)-17 subset, whereas memory T cells specific for Mycobacterium ..
  57. pmc Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses
    Celia Murciano
    Department of Oral Immunology, Floor 28, Tower Wing, King s College London Dental Institute, King s College London, London SE1 9RT, United Kingdom
    Infect Immun 79:4902-11. 2011
    Oral epithelial cells discriminate between the yeast and hyphal forms of Candida albicans via the mitogen-activated protein kinase (MAPK) signaling pathway...
  58. pmc The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 10:1034-42. 2011
    Living as a commensal, Candida albicans must adapt and respond to environmental cues generated by the mammalian host and by microbes comprising the natural flora. These signals have opposing effects on C...
  59. ncbi Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
    ..Dectin-1, when stimulated by the beta-glucan curdlan or by Candida albicans, induced a second signaling pathway mediated by the serine-threonine kinase Raf-1, which integrated with the ..
  60. ncbi Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
    C Stokes
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, Dublin 2, Ireland
    Fungal Genet Biol 44:920-31. 2007
    b>Candida albicans and C. dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two infection models...
  61. pmc Function of Candida albicans adhesin Hwp1 in biofilm formation
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    Eukaryot Cell 5:1604-10. 2006
    Hwp1 is a well-characterized Candida albicans cell surface protein, expressed only on hyphae, that mediates tight binding to oral epithelial cells...
  62. pmc Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo
    Keunsook K Lee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Antimicrob Agents Chemother 56:208-17. 2012
    b>Candida albicans cells with increased cell wall chitin have reduced echinocandin susceptibility in vitro. The aim of this study was to investigate whether C...
  63. pmc Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
    Quynh T Phan
    Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Biol 5:e64. 2007
    b>Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C...
  64. pmc A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans
    Deborah A Smith
    School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Mol Biol Cell 15:4179-90. 2004
    ..Hog1 stress-activated protein kinase (SAPK) in osmotic and oxidative stress responses in the human pathogen Candida albicans. In this study, we have characterized the role of Hog1 in mediating these and other stress responses in C...
  65. pmc Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans
    Michelle D Leach
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 79:1574-93. 2011
    ..We have combined molecular, cellular and proteomic approaches to examine the roles of ubiquitination in Candida albicans, because little is known about ubiquitination in this major fungal pathogen of humans...
  66. pmc Patients with long-term oral carriage harbor high-persister mutants of Candida albicans
    Michael D LaFleur
    Antimicrobial Discovery Center and Department of Biology, Northeastern University, 360 Huntington Avenue, 134 Mugar Hall, Boston, MA 02115, USA
    Antimicrob Agents Chemother 54:39-44. 2010
    ..In order to test this possibility, 150 isolates of Candida albicans and C...
  67. pmc Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen
    Iuliana V Ene
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Cell Microbiol 14:1319-35. 2012
    ..To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defences while adapting to dynamic changes in nutrient ..
  68. pmc Zap1 control of cell-cell signaling in Candida albicans biofilms
    Shantanu Ganguly
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Eukaryot Cell 10:1448-54. 2011
    Biofilms of Candida albicans include both yeast cells and hyphae. Prior studies indicated that a zap1Δ/Δ mutant, defective in zinc regulator Zap1, has increased accumulation of yeast cells in biofilms...
  69. ncbi Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans
    Steven Bates
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Biol Chem 281:90-8. 2006
    The outer layer of the Candida albicans cell wall is enriched in highly glycosylated mannoproteins that are the immediate point of contact with the host and strongly influence the host-fungal interaction...
  70. pmc Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model
    Martin J Spiering
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, University of Dublin, Trinity College, Dublin 2, Ireland
    Eukaryot Cell 9:251-65. 2010
    b>Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C...
  71. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ..of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with beta-glucan or Candida albicans. In contrast, fungal phagocytosis and fungal killing were normal in the patients, explaining why dectin-1 ..
  72. ncbi The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
    Oliver Reuss
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Gene 341:119-27. 2004
    The construction of Candida albicans mutants by targeted gene disruption usually depends on the use of nutritional markers for the selection of prototrophic transformants from auxotrophic host strains, but it is becoming increasingly ..
  73. ncbi The glyoxylate cycle is required for fungal virulence
    M C Lorenz
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA
    Nature 412:83-6. 2001
    b>Candida albicans, a normal component of the mammalian gastrointestinal flora, is responsible for most fungal infections in immunosuppressed patients...
  74. ncbi Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    Olaf Gross
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Nature 459:433-6. 2009
    ..receptors, controls both pro-IL-1beta synthesis and inflammasome activation after cell stimulation with Candida albicans. Whereas Syk signalling for pro-IL-1beta synthesis selectively uses the Card9 pathway, inflammasome ..
  75. pmc Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 4:e5392. 2009
    ..a laminarin-conjugate vaccine confer cross-protection to mice challenged with major fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans...
  76. ncbi Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 200:152-7. 2009
    b>Candida albicans is the most common human fungal pathogen, yet the pathogenesis of C. albicans infection remains incompletely understood. We hypothesized that C...
  77. pmc Dispersion as an important step in the Candida albicans biofilm developmental cycle
    Priya Uppuluri
    Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, United States of America
    PLoS Pathog 6:e1000828. 2010
    ..Overall, our results offer novel and important insight into the phenomenon of C. albicans biofilm dispersion, a key part of the biofilm developmental cycle, and provide the basis for its more detailed analysis...
  78. ncbi A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique
    Donatella Pietrella
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Vaccine 28:1717-25. 2010
    ..To monitor infection, an in vivo imaging technique exploiting genetically engineered, luminescent Candida albicans was adopted, and compared with measurements of colony forming units...
  79. ncbi Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Cell Microbiol 7:1546-54. 2005
    The fascinating ability of Candida albicans to undergo dramatic changes in cellular morphology has invited speculation that this plasticity in form contributes to the virulence of the organism...
  80. pmc Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence
    Patricia L Carlisle
    Department of Microbiology and Immunology, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7758, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 106:599-604. 2009
    b>Candida albicans, the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attached end-to-end). Because typical C...
  81. ncbi Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides
    David Bergin
    Department of Biology, Medical Mycology Unit, NICB, National University of Ireland Maynooth, Co Kildare, Ireland
    Microbes Infect 8:2105-12. 2006
    Pre-exposure of the larvae of Galleria mellonella to Candida albicans or Saccharomyces cerevisiae protects against a subsequent infection with 10(6) C. albicans cells...
  82. pmc Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Eukaryot Cell 4:1203-10. 2005
    b>Candida albicans is a pathogenic fungus able to change morphology in response to variations in its growth environment...
  83. ncbi Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice
    A Tuite
    Department of Biochemistry, Center for the Study of Host Resistance, McGill University, 3655 Promenade Sir William Osler, Rm 907, Montreal, Quebec, Canada H3G 1Y6
    Genes Immun 6:672-82. 2005
    The importance of host factors in determining susceptibility to systemic Candida albicans infections is evident in both humans and mice...
  84. ncbi Hydrolytic enzymes as virulence factors of Candida albicans
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Mycoses 48:365-77. 2005
    b>Candida albicans is a facultative pathogenic micro-organism that has developed several virulence traits enabling invasion of host tissues and avoidance of host defence mechanisms...
  85. pmc Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 17:1018-32. 2006
    The resistance of Candida albicans to many stresses is dependent on the stress-activated protein kinase (SAPK) Hog1. Hence we have explored the role of Hog1 in the regulation of transcriptional responses to stress...
  86. pmc Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes
    Allen Wang
    Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
    Mol Cell Biol 29:4406-16. 2009
    ..How it is regulated developmentally in multimorphic fungi is not known. In Candida albicans, degradation of septa during yeast growth is accomplished by enzymes encoded by Ace2 activated genes ..
  87. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    Candida dubliniensis is the closest known relative of Candida albicans, the most pathogenic yeast species in humans. However, despite both species sharing many phenotypic characteristics, including the ability to form true hyphae, C...
  88. ncbi An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans
    Ziva Weissman
    Department of Molecular Microbiology, Technion B Rappaport Faculty of Medicine, and the Rappaport Institute for Research in the Medical Sciences, Haifa 31096, Israel
    Mol Microbiol 69:201-17. 2008
    The fungal pathogen Candida albicans is able to utilize haemin and haemoglobin as iron sources...
  89. pmc Candida albicans and Staphylococcus aureus form polymicrobial biofilms: effects on antimicrobial resistance
    Melphine M Harriott
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 53:3914-22. 2009
    b>Candida albicans readily forms biofilms on the surface on indwelling medical devices, and these biofilms serve as a source of local and systemic infections. It is estimated that 27% of nosocomial C...
  90. pmc Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways
    Nidhi Sahni
    Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Biol 8:e1000363. 2010
    ..evolved signal transduction pathway that regulates the pheromone response of the white cell phenotype in Candida albicans. The elucidation of this last component, Tec1, establishes a comprehensive description of the pheromone ..
  91. pmc Development and validation of an in vivo Candida albicans biofilm denture model
    Jeniel E Nett
    Department of Medicine, University of Wisconsin, 600 Highland Ave, Room H4 572, Madison, WI 53792, USA
    Infect Immun 78:3650-9. 2010
    ..We developed a rodent acrylic denture model and characterized the Candida albicans and mixed oral bacterial flora biofilm formation, architecture, and drug resistance in vivo, using time ..
  92. pmc Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
    Jeffrey M Becker
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 107:22044-9. 2010
    One potentially rich source of possible targets for antifungal therapy are those Candida albicans genes deemed essential for growth under the standard culture (i.e...
  93. ncbi Candida albicans iron acquisition within the host
    Ricardo S Almeida
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    FEMS Yeast Res 9:1000-12. 2009
    As a commensal and opportunistic pathogen, Candida albicans possesses a range of determinants that contribute to survival, persistence and virulence...
  94. pmc Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice
    Lin Lin
    The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California, USA
    PLoS Pathog 5:e1000703. 2009
    We sought to define protective mechanisms of immunity to Staphylococcus aureus and Candida albicans bloodstream infections in mice immunized with the recombinant N-terminus of Als3p (rAls3p-N) vaccine plus aluminum hydroxide (Al(OH(3)) ..
  95. ncbi Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    Curr Biol 15:1150-5. 2005
    ..are extensively defined for many bacterial pathogens [3, 4, and 5], but not for fungal pathogens such as Candida albicans. Elongated filaments called hyphae are a prominent feature of C...
  96. pmc Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus
    Alexandra Brand
    School of Medical Sciences, Institute of Medical Sciences, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Eukaryot Cell 3:900-9. 2004
    Uridine auxotrophy, based on disruption of both URA3 alleles in diploid Candida albicans strain SC5314, has been widely used to select gene deletion mutants created in this fungus by "Ura-blasting" and PCR-mediated disruption...
  97. ncbi Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice
    Donna M MacCallum
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB5 2ZD, UK
    Mycoses 48:151-61. 2005
    We characterized the intravenous (i.v.) challenge model for disseminated Candida albicans infection in female BALB/c and DBA/2 mice...
  98. pmc Strain-dependent differences in host response to Candida albicans infection in mice are related to organ susceptibility and infectious load
    R B Ashman
    Pathology Department, University of Western Australia, Nedlands, Australia
    Infect Immun 64:1866-9. 1996
    After systemic infection with the yeast Candida albicans, inbred mice show substantial differences in mortality, organ colonization, and severity of tissue damage...
  99. pmc Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection
    Donna M MacCallum
    Institute of Microbiology, University of Lausanne and University Hospital Center, CH 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 54:1476-83. 2010
    ..These mechanisms are often combined in azole-resistant Candida albicans isolates recovered from patients. However, the precise contributions of individual mechanisms to C...
  100. ncbi Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae
    Marc Brennan
    Medical Mycology Unit, Department of Biology, National University of Ireland, Co Kildare, Maynooth, Ireland
    FEMS Immunol Med Microbiol 34:153-7. 2002
    b>Candida albicans is a dimorphic human pathogen in which the yeast to hyphal switch may be an important factor in virulence in mammals...
  101. ncbi The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ..The extracellular domain of Dectin-2 exhibited binding to live Candida albicans and the Saccharomyces-derived particle zymosan...

Research Grants75

  1. Candida albicans oral biofilm
    WELDA CHAFFIN; Fiscal Year: 2004
    b>Candida albicans is a commensal that colonizes skin and mucosal surfaces including the oral cavity. The organism is also an agent of opportunistic disease of these surfaces as well as internal disseminated disease...
  2. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    b>Candida albicans is a commensal member of the human microflora and is the most common causative agent of fungal-related disease with particular significance in immuno-compromised individuals with HIV disease/AIDS, ranging from mild ..
  3. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida albicans also demonstrate an electricidal effect.} We have shown that electrical current is active against S...
  4. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..We now have access to Candida albicans that has been genetically engineered to express Gaussia princeps luciferase and Aspergillus fumigates ..
  5. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..coli flavohemoglobin and a series of fungal (Candida albicans and Aspergillus fumigatus) flavohemoglobins, which catalyze this reaction as part of a defense mechanism ..
  6. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..b>Candida albicans was also recently discovered to undergo same-sex mating, and cryptic sexual cycles are being found for other ..
  7. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    b>Candida albicans is a widespread human fungal pathogen that causes high rates of mortality during systemic infections (candidiasis)...
  8. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..b>Candida albicans is the most common human fungal pathogen, causing both mucosal and systemic infections and remains a major ..
  9. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..is to investigate the effects of cannabinoids (THC and 2-arachidonoylglycerol (2-AG)) and CB2R on a systemic Candida albicans (C. albicans) infection. C...
  10. Centromere Structure and Function in Candida albicans
    Judith G Berman; Fiscal Year: 2012
    b>Candida albicans is an important human fungal pathogen that causes superficial mucosal and lethal systemic infections. Prophylactic antifungal treatments often result in the appearance of acquired drug resistance. C...
  11. Genetic and Evolutionary Basis of Fungal Drug Resistance
    Zhenglong Gu; Fiscal Year: 2013
    ..cerevisiae and in a pathogenic yeast species, Candida albicans. The function and evolution of other genes identified in Aim 1 will also be investigated...
  12. RNA CONFORMATION AND CATALYSIS
    David P Bartel; Fiscal Year: 2013
    ..cerevisiae) and Candida albicans (a common human pathogen)...
  13. Enzymology of Post-translational Modifications
    Carol A Fierke; Fiscal Year: 2013
    ..we propose to: (1) investigate determinants of prenyltransferase substrate specificity for mammalian and Candida albicans enzymes and analyze the effects of individual prenylation pathway modifications on protein localization and ..
  14. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida species are the most important fungal pathogens of humans, and Candida albicans, in particular, is the most common cause of oropharyngeal candidiasis, which is an infection that affects ..
  15. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..e. Mycobacterium tuberculosis, Listeria monocytogenes) and other fungi (i.e. Cryptococcus neoformans, Candida albicans) demonstrates that specific antibody can improve the ability of the host to combat these infecting microbes...
  16. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    ..and render resistance to a broad spectrum of keratitis causing pathogens, including Pseudomonas aeruginosa, Candida albicans and Aspergillus fumigates...
  17. Investigation of the structure and function of urea amidolyase
    MARTIN RAOUL ST. MAURICE; Fiscal Year: 2012
    ..The enzyme activity influences a yeast-to-hyphae switch that allows Candida albicans to escape from macrophages during systemic infections...
  18. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..experiments show A[unreadable] inhibits the growth of eight clinically important microorganisms, including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria ..
  19. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2012
    ..Our research focuses on signaling cascades as targets for antifungal drugs. Studies are proposed on Candida albicans, the most common human fungal pathogen that remains a major mucosal pathogen in AIDS patients who fail or do ..
  20. Genetics and visualization of innate host response to C. albicans infection in vi
    Robert T Wheeler; Fiscal Year: 2012
    ..b>Candida albicans is a ubiquitous commensal and the most frequent cause of fungal disease in humans...
  21. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..We will test several microorganisms, including gram (+), gram (-), Candida albicans and Chlamydia trachomatis...
  22. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..Phase I research and development will focus on the detection and differentiation of Candida albicans and Candida glabrata, two of the most common strains of Candida...
  23. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ..In preliminary studies, we found that key components of Candida albicans and Cryptococcus neoformans pathogenesis in mammals are also involved in nematode killing...
  24. N-acetylglucosamine signaling in fungi
    James B Konopka; Fiscal Year: 2012
    ..GlcNAc also stimulates the human fungal pathogen Candida albicans to induce the expression of virulence factors, including a switch from budding to hyphal growth. Therefore, C...
  25. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..improved drug delivery systems to the brain;and David Soll evaluates factors of pathogenicity in the yeast, Candida albicans, the frequent underlying reason of opportunistic infections in immunosuppressed patients...
  26. Identifying novel small molecules for improved antifungal drug treatment
    Martha L Bulyk; Fiscal Year: 2012
    ..PDR TFs involved in antifungal drug resistance in Saccharomyces cerevisiae as well as the pathogenic species Candida albicans and Candida glabrata...
  27. Identification of broad-spectrum antifungal efflux pump inhibitors
    Richard Cannon; Fiscal Year: 2009
    ..to the panel of yeast strains expressing efflux pumps from the following clinically relevant fungi: Candida albicans, Candida glabrata, Candida krusei and Cryptococcus neoformans...
  28. Extracellular pH modulation by Candida albicans in vitro and in vivo
    Michael C Lorenz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida albicans is the most important human-associated fungus, existing as both an integral component of the microbiota and as a pathogen of multiple organ systems. C...
  29. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..b>Candida albicans, a common opportunistic fungal pathogen, is the leading cause of invasive fungal disease in immunocompromised ..
  30. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
    ..a particularly important role in controlling mucocutaneous fungal infections caused by the commensal yeast, Candida albicans. Indeed, humans or mice with IL-17 receptor deficiencies or with antibodies against IL-17 are highly prone to ..
  31. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida albicans is an opportunistic pathogen that causes oropharyngeal disease in a large and diverse population of patients, including those with HIV/AIDS, Sjogren's syndrome, diabetes mellitus,..
  32. Nlrp3 inflammasome signaling in immune responses to Candida albicans
    Fayyaz S Sutterwala; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Candida albicans is a fungal pathogen that causes a wide variety of opportunistic infections, particularly in hospitalized ..
  33. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..For comparison, events associated with ingestion of the yeast Candida albicans via the mannose receptor (MR) will be studied...
  34. The Role of Genetic Variation in the Fungal/Host Interaction
    Gerald R Fink; Fiscal Year: 2012
    ..Pathogenic fungi such as Candida albicans, and the non-pathogen, S...
  35. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    ..Previous work in fungal pathogens such as Candida albicans and Candida glabrata has provided clear implication of gene transcription as a key determinant of drug ..
  36. Analysis of Candida albicans filamentation using SILAC
    DEREK PAUL THOMAS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pathogenic potential of Candida albicans is intimately related with the way this organism senses and reacts to its surrounding environment, which, in the case of C. albicans, is the host...
  37. Genetic Heterogeniety of the Hyper IgE Syndrome
    TALAL AMINE CHATILA; Fiscal Year: 2010
    ..Patients are particularly susceptible to Staphylococcus aureus and Candida albicans, and suffer from skin abscesses, pneumonia with pneumatocele formation, and other deep-seated infections...
  38. A Structural Approach for Treating Drug Resistant Fungal Pathogens
    Mitchell W Mutz; Fiscal Year: 2013
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate...
  39. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Scott Moye-Rowley; Fiscal Year: 2013
    ..cerevisiae) that efflux drugs out of the cell. The pathogenic Candida species, Candida albicans and Candida glabrata, express homologues of ScPdr5 and can acquire similar multidrug resistant phenotypes...
  40. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ..b>Candida albicans causes both mucosal and disseminated disease...
  41. Innate Immune Recognition of Candida albicans Infection in a C. elegans Model
    Read Pukkila-Worley; Fiscal Year: 2013
    ..b>Candida albicans is found in the intestine of virtually all healthy humans...
  42. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections
    Mitchell W Mutz; Fiscal Year: 2011
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate...
  43. Small molecule inhibitors of a Candida albicans histone modifying enzyme
    JESSICA RAMOS LOPES DA ROSA-SPIEGLER; Fiscal Year: 2012
    b>Candida albicans is a widespread human fungal pathogen that causes high rates of mortality during systemic infections, and is particularly dangerous for immunocompromised AIDS patients. Because fungi such as C...
  44. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..ATAK) cells diminishes their replicative capacity and markedly increases the efficiency with which they kill Candida albicans, consistent with the cells'maturation towards mature granulocytes...
  45. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010
    ..genes that require Ess1, (3) Use structure and function analysis to examine enzyme-substrate interactions by Candida albicans Ess1, with the long-term goal of exploiting key differences between the fungal and human enzymes for ..
  46. Synthetic glycopeptide vaccines that enhance resistance to candidiasis
    Hong Xin; Fiscal Year: 2013
    ..Novel fully synthetic peptide and glycopeptide vaccines against Candida albicans cell surface epitopes have been successfully used to combat disseminated candidiasis in mice in our lab...
  47. Mechanisms of Host Adaptation for Candida albicans
    PETER JOHN ESPENSHADE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate commensal organism Candida albicans colonizes the intestinal tract of its human host, and normally causes no disease...
  48. Can Sexually Transmitted Pathogens Impact the Efficacy of HIV-1 Microbicides?
    SUSANA NOEMI ASIN; Fiscal Year: 2013
    ..Specific Aim 2 will explore TLR-dependent immunological mechanisms by which HSV-2, Neisseria gonorrhoeae, and Candida albicans modulate the efficacy of lead microbicides...
  49. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel H Kaplan; Fiscal Year: 2013
    ..generate an antigen-specific infection model by combining an existing model of cutaneous Candidiasis with Candida albicans that we will engineer to express ovalbumin...
  50. MICROBICIDAL SALIVARY HISTIDINE-RICH PROTEINS
    Frank G Oppenheim; Fiscal Year: 2012
    ..A major focus of investigation is the antifungal effect of histatins on the oral pathogen Candida albicans, causing the most frequently occurring oral fungal infection...
  51. The novel family of superoxide dismutase enzymes in Candida albicans
    Valeria C Culotta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The infectious yeast Candida albicans remains an important concern in public health, particularly with immune-compromised individuals. One set of virulence factors for C...
  52. Biological Implications of Tetramic Acid
    Kim D Janda; Fiscal Year: 2010
    ..Significantly, we have shown that C12-TA affects morphology a in Candida albicans. [PARAGRAPH] Taken in total, we will present a set of hypotheses with highly focused experiments elucidate ..
  53. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard R Katz; Fiscal Year: 2012
    ..Our early studies indicate that the enzyme regulates phagocytosis and killing of the yeast Candida albicans in pulmonary macrophages and activation of signaling molecules called mitogen-activated protein kinases in ..
  54. Genome Integrity in Candida albicans
    Judith G Berman; Fiscal Year: 2013
    ....
  55. Structural Requirements for Sterol 14alpha-Demethylases
    Galina I Lepesheva; Fiscal Year: 2013
    ..Second, we will test these scaffolds and their derivatives as potential drugs for treatment of infection by Candida albicans and Aspergillus (A) fumigatus and A. flavus...
  56. Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
    Jatin M Vyas; Fiscal Year: 2013
    ..Diverse pathogens including HIV-1, E. coli, Plasmodium falciparum and Candida albicans all manipulate mammalian tetraspanins for cell invasion or intracellular trafficking...
  57. Development of Monoclonal Antibody (Mab) Biologics against Neonatal Candidiasis
    Jose L Lopez-Ribot; Fiscal Year: 2013
    ..provided by applicant): Candidiasis represents the most common fungal infection in hospitalized patients and Candida albicans remains the main etiologic agent of candidiasis, as this otherwise normal commensal of humans is capable of ..
  58. New elements of the Target of Rapamycin pathway in Candida albicans
    JULIA R KOEHLER; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Candida albicans is the most common cause of invasive fungal infections, which even treated appropriately, carry a high ..
  59. Phenotypic Plasticity and Inter-Species Communication in Candida Albicans
    STEPHEN KNOX JONES; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The pathogenic yeast, Candida albicans is a major constituent of the human flora with a plasticity that allows it to thrive both as a commensal organism and as a life-threatening pathogen...
  60. REGULATION OF FILAMENTOUS GROWTH IN YEAST
    Haoping Liu; Fiscal Year: 2013
    b>Candida albicans is one of the most frequently isolated fungal pathogens of humans. It can undergo reversible morphogenetic transitions between budding yeast, pseudohyphal, and hyphal growth forms...
  61. Synthetic Genetic Analysis of the RAM network in C. albicans
    Anuj Kumar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Candida albicans is an important opportunistic fungal pathogen that causes both mucosal and invasive disease in immunocompromised patients...
  62. Genome-wide investigations in fungal pathogens utilizing an invertebrate model ho
    Eleftherios Mylonakis; Fiscal Year: 2010
    ..Implement whole animal C. elegans assays to identify virulence traits associated with Candida albicans and Candida glabrata infection. Based on our previous C. elegans assays, including C...
  63. Phenotypic Switching in Candida albicans and its Role in Pathogenesis
    RICHARD JOHN BENNETT; Fiscal Year: 2010
    b>Candida albicans is an opportunistic pathogen capable of causing debilitating mucosal infections as well as life-threatening systemic infections...
  64. SEEKING THE YEAST SPARKING STEROL
    Martin Bard; Fiscal Year: 1991
    Opportunistic fungal pathogens, particularly Candida albicans, are a more serious problem as a result of the increasing number of immunocompromised individuals (cancer patients and AIDS victims)...
  65. FIBRONECTIN RECEPTOR IN CANDIDA TROPICALIS
    MARGARET HOSTETTER; Fiscal Year: 2003
    Among Candida species, Candida tropicalis ranks second only to Candida albicans as a cause or morbidity and mortality among immunocompromised hosts, especially in patients undergoing cancer chemotherapy or those with fungal endocarditis...
  66. Immunity to Oral Candidiasis
    SARAH GAFFEN; Fiscal Year: 2009
    ..Oropharyngeal candidiasis (OPC), caused by the yeast Candida albicans, is a major disease associated with immunosuppression due to chemotherapy, AIDS or congenital ..
  67. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    ..b>Candida albicans, the primary cause of candidosis, is a member of the normal flora and grows either in yeast of hyphal form...
  68. Glucan Binding to Azole Drugs: A Novel Resistance Mechanism in Candida albicans
    THEODORE WHITE; Fiscal Year: 2009
    Project Summary The pathogenic yeast Candida albicans (Ca) is a frequent cause of oral and systemic fungal infections in immune-compromised people and of vaginal infections in women...
  69. MOLECULAR MARKER FOR INVASIVE CANDIDA ALBICANS
    MARGARET HOSTETTER; Fiscal Year: 2001
    The opportunistic pathogen Candida albicans adheres to epithelium and replicates at the mucosal barrier prior to invading the bloodstream...
  70. Role of extracellular matrix proteins in Candida biofilm formation
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2010
    b>Candida albicans (CA) is the most commonly isolated fungus associated with biofilms [extracellular matrix (ECM)-encased microbial communities formed on indwelling medical devices which are resistant against commonly used antifungals...
  71. Salivary Gland IL-17R Signaling in Oral Candidiasis
    HEATHER RAQUEL CONTI; Fiscal Year: 2012
    ..by applicant): Oropharyngeal candidiasis (OPC) is an opportunistic infection caused by the commensal fungus Candida albicans (C. albicans)...
  72. TWO-COMPONENT SIGNAL PROTEINS OF ASPERGILLUS FUMIGATUS
    Richard Calderone; Fiscal Year: 2003
    ..The parent grant is entitled, "The response regulator gene (CaSSK1) of Candida albicans, 1 R0l A147047-01. The study will be performed in the laboratories of Drs...
  73. Centromere structure and isochromosome formation in Candida albicans
    Laura S Burrack; Fiscal Year: 2010
    b>Candida albicans is the most prevalent human fungal pathogen and is capable of causing invasive candidiasis, a severe disease with high mortality rates and medical costs...
  74. Histidine Kinase 2-Component Protein of Candida Albicans
    Richard Calderone; Fiscal Year: 2009
    ..observations during the past three years, we have shown that the Chklp two-component histidine kinase [HK] of Candida albicans regulates cell wall biosynthesis. These data were achieved through an analysis of the chkl deletion mutant...
  75. MEMBRANE FUNCTION DURING GERMINATION OF CANDIDA ALBICANS
    RONALD CIHLAR; Fiscal Year: 1990
    ..effect of perturbing membrane biogenesis on yeast cell germination and chitin biosynthesis will be studied in Candida albicans. Our approach in investigating these issues will be to dissect the steps leading to germination by employing ..