candida

Summary

Summary: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)

Top Publications

  1. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
  2. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
  3. pmc The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
    Diane O Inglis
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D667-74. 2012
  4. pmc Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis
    Ying Lien Chen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 10:803-19. 2011
  5. pmc Candida infections of medical devices
    Erna M Kojic
    Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Microbiol Rev 17:255-67. 2004
  6. pmc Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis
    Alessandro Guida
    School of Medicine and Medical Science, Conway Institute, UniversityCollege Dublin, Belfield, Dublin 4, Ireland
    BMC Genomics 12:628. 2011
  7. ncbi Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
    C Stokes
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, Dublin 2, Ireland
    Fungal Genet Biol 44:920-31. 2007
  8. pmc Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model
    Martin J Spiering
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, University of Dublin, Trinity College, Dublin 2, Ireland
    Eukaryot Cell 9:251-65. 2010
  9. ncbi Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition
    Sonia Silva
    Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar 4710 057, Braga, Portugal
    Med Mycol 47:681-9. 2009
  10. pmc Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 12:80-96. 1999

Research Grants

  1. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
  2. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
  3. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
  4. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
  5. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
  6. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
  7. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
  8. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
  9. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
  10. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009

Detail Information

Publications338 found, 100 shown here

  1. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
    ..b>Candida albicans remains the predominant cause of IC, accounting for over half of all cases, but Candida glabrata has ..
  2. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
    b>Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens...
  3. pmc The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
    Diane O Inglis
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D667-74. 2012
    The Candida Genome Database (CGD, http://www.candidagenome...
  4. pmc Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis
    Ying Lien Chen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 10:803-19. 2011
    b>Candida dubliniensis is an emerging pathogenic yeast species closely related to Candida albicans and frequently found colonizing or infecting the oral cavities of HIV/AIDS patients. Drug resistance during C...
  5. pmc Candida infections of medical devices
    Erna M Kojic
    Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Microbiol Rev 17:255-67. 2004
    ..medical devices is escalating, and an increasing proportion of device-related infections are being caused by Candida spp. Candida spp...
  6. pmc Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis
    Alessandro Guida
    School of Medicine and Medical Science, Conway Institute, UniversityCollege Dublin, Belfield, Dublin 4, Ireland
    BMC Genomics 12:628. 2011
    b>Candida parapsilosis is one of the most common causes of Candida infection worldwide. However, the genome sequence annotation was made without experimental validation and little is known about the transcriptional landscape...
  7. ncbi Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
    C Stokes
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, Dublin 2, Ireland
    Fungal Genet Biol 44:920-31. 2007
    b>Candida albicans and C. dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two infection models...
  8. pmc Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model
    Martin J Spiering
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, University of Dublin, Trinity College, Dublin 2, Ireland
    Eukaryot Cell 9:251-65. 2010
    b>Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C...
  9. ncbi Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition
    Sonia Silva
    Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar 4710 057, Braga, Portugal
    Med Mycol 47:681-9. 2009
    Most cases of candidiasis have been attributed to C. albicans, but recently, non- Candida albicans Candida (NCAC) species have been identified as common pathogens...
  10. pmc Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 12:80-96. 1999
    Until recently, Candida glabrata was considered a relatively nonpathogenic commensal fungal organism of human mucosal tissues. However, with the increased use of immunosuppressive agents, mucosal and systemic infections caused by C...
  11. ncbi Candida biofilms and their role in infection
    L Julia Douglas
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Trends Microbiol 11:30-6. 2003
    Pathogenic fungi in the genus Candida can cause both superficial and serious systemic disease, and are now recognized as major agents of hospital-acquired infection...
  12. ncbi Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009)
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 38:65-9. 2011
    ..by reference methods were analysed to compare the antifungal resistance profiles and species distribution of Candida bloodstream infection (BSI) isolates obtained from patients in the Intensive Care Unit (ICU) and those from non-..
  13. ncbi Candida biofilm resistance
    Pranab K Mukherjee
    Department of Dermatology, Center for Medical Mycology, Case Western Reserve University, 11100 Euclid Avenue, LKS 5028 Cleveland, OH 44106 5028, USA
    Drug Resist Updat 7:301-9. 2004
    ..b>Candida species are the most common fungi isolated from these infections, and biofilms formed by these fungal organisms ..
  14. pmc Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins
    D M Kuhn
    Division of Infectious Diseases, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 46:1773-80. 2002
    ..Evidence suggests that Candida biofilms have dramatically reduced susceptibility to antifungal drugs...
  15. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    b>Candida dubliniensis is the closest known relative of Candida albicans, the most pathogenic yeast species in humans. However, despite both species sharing many phenotypic characteristics, including the ability to form true hyphae, C...
  16. ncbi Innate immune mechanisms for recognition and uptake of Candida species
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Trends Immunol 31:346-53. 2010
    b>Candida species are major causes of infections affecting either body surfaces or the deep tissues...
  17. ncbi Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Infect Dis 193:1014-22. 2006
    b>Candida species are the predominant fungal pathogens in humans and an important cause of mortality in immunocompromised patients. We developed a model of candidiasis in Toll (Tl)-deficient Drosophila melanogaster...
  18. pmc Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex
    Jennifer L Reedy
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 19:891-9. 2009
    b>Candida species are microbial pathogens originally thought to be asexual, but several are now recognized as sexual or parasexual...
  19. pmc Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 45:1174-83. 2001
    b>Candida glabrata has been often isolated from AIDS patients with oropharyngeal candidiasis treated with azole antifungal agents, especially fluconazole...
  20. pmc Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan
    Jeniel E Nett
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    J Infect Dis 202:171-5. 2010
    ..Biofilms formed by Candida albicans, the most common fungal pathogen, survive exposure to extraordinarily high drug concentrations...
  21. ncbi Species distribution and antifungal susceptibility of Candida bloodstream isolates in Kuwait: a 10-year study
    Eiman M Mokaddas
    Department of Microbiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110
    J Med Microbiol 56:255-9. 2007
    Bloodstream infections due to Candida species are important complications in severely ill hospitalized patients...
  22. ncbi Protein glycosylation in Candida
    Hector M Mora-Montes
    Institute of Medical Sciences, University of Aberdeen, UK
    Future Microbiol 4:1167-83. 2009
    ..This has led to an increasing interest in Candida glycobiology, with an emphasis on the identification of enzymes essential for glycoprotein and adhesion ..
  23. pmc Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A
    Maria P Frushicheva
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 1062, USA
    Chembiochem 13:215-23. 2012
    ..is explored by simulating the hydrolysis of enantiomers of an α-substituted ester by wild-type and mutant Candida antarctica lipase A, using several strategies...
  24. ncbi Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species
    Eugénia Pinto
    Department of Microbiology CEQOFFUP CEQUIMED, Faculty of Pharmacy, University of Porto, 4050 047 Porto, Portugal
    J Med Microbiol 58:1454-62. 2009
    ..were used to evaluate the antifungal activity of the clove oil and its main component, eugenol, against Candida, Aspergillus and dermatophyte clinical and American Type Culture Collection strains...
  25. ncbi Detoxification of sugarcane bagasse hydrolysate improves ethanol production by Candida shehatae NCIM 3501
    Anuj Kumar Chandel
    Lignocellulose Biotechnology Laboratory, Department of Microbiology, University of Delhi South Campus, Benito Juarez Marg, New Delhi 110 021, India
    Bioresour Technol 98:1947-50. 2007
    ..5%) without affecting furans and acetic acid content in the hydrolysate. Fermentation of these hydrolysates with Candida shehatae NCIM 3501 showed maximum ethanol yield (0...
  26. ncbi Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
    M A Pfaller
    University of Iowa, Iowa City, United States
    Drug Resist Updat 14:164-76. 2011
    ..established clinical breakpoints (CBPs) for caspofungin (CSF), micafungin (MCF) and anidulafungin (ANF) versus Candida. The same CBP (susceptible (S): MIC ≤ 2 mcg/ml; non-S: MIC > 2 mcg/ml) was applied to all echinocandins and ..
  27. ncbi Relative frequency of albicans and the various non-albicans Candida spp among candidemia isolates from inpatients in various parts of the world: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Infect Dis 14:e954-66. 2010
    Candidemia is among the leading causes of nosocomial bloodstream infections and is associated with significant mortality. Several centers have published data regarding the incidence and relative frequency of Candida spp.
  28. ncbi Assessment of Candida species colonization and denture-related stomatitis in complete denture wearers
    Kamiar Zomorodian
    Department of Medical Mycology and Parasitology, School of Medicine and Center of Basic Researches in Infectious Diseases, Shiraz University of Medical Sciences, Shiraz, Iran
    Med Mycol 49:208-11. 2011
    b>Candida species are considered the primary causative agents of denture stomatitis, but their role in colonization and disease in denture wearers remains undefined...
  29. pmc In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis
    Patricia M Tavares
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS, Bloco I, Ilha do Fundao, Rio de Janeiro, RJ 21941590, Brazil
    Antimicrob Agents Chemother 52:4522-5. 2008
    We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans, inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells...
  30. pmc Candida biofilms: an update
    Gordon Ramage
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
    Eukaryot Cell 4:633-8. 2005
  31. ncbi Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry
    David L Horn
    Div of Infectious Diseases, Thomas Jefferson University, Ste 210, 211 S 9th St, Philadelphia, PA 19107, USA
    Clin Infect Dis 48:1695-703. 2009
    Candidemia remains a major cause of morbidity and mortality in the health care setting, and the epidemiology of Candida infection is changing.
  32. ncbi Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes
    A L Mavor
    Robert Koch Institut, Berlin, Germany
    Curr Drug Targets 6:863-74. 2005
    b>Candida species, in particular C. albicans, represent a major threat to immunocompromised patients...
  33. pmc Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser
    David A Fitzpatrick
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Genomics 11:290. 2010
    b>Candida species are the most common cause of opportunistic fungal infection worldwide. Recent sequencing efforts have provided a wealth of Candida genomic data...
  34. ncbi Candida biofilms on implanted biomaterials: a clinically significant problem
    Gordon Ramage
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK
    FEMS Yeast Res 6:979-86. 2006
    ..range of biomaterials used in clinical practice have been shown to support colonization and biofilm formation by Candida spp...
  35. pmc Candida infections of the genitourinary tract
    Jacqueline M Achkar
    Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 1223, Bronx, NY 10461, USA
    Clin Microbiol Rev 23:253-73. 2010
    All humans are colonized with Candida species, mostly Candida albicans, yet some develop diseases due to Candida, among which genitourinary manifestations are extremely common...
  36. pmc The mitochondrial genome of the pathogenic yeast Candida subhashii: GC-rich linear DNA with a protein covalently attached to the 5' termini
    Dominika Fricova
    Department of Biochemistry, Comenius University, Faculty of Natural Sciences, Mlynska dolina CH 1, 842 15 Bratislava, Slovak Republic
    Microbiology 156:2153-63. 2010
    ..of fungal mitochondrial genomes, we determined the complete DNA sequence of the mitochondrial genome of the yeast Candida subhashii and found that it exhibits a number of peculiar features...
  37. pmc Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides
    E J Helmerhorst
    Department of Oral Biochemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 43:702-4. 1999
    ..analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata ..
  38. ncbi Candida parapsilosis keratitis
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    Cornea 22:51-5. 2003
    To present clinical, microbiologic, and histopathologic features of keratitis due to Candida parapsilosis.
  39. ncbi Severe Candida spp. infections: new insights into natural immunity
    Jos W M Van der Meer
    Department Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Antimicrob Agents 36:S58-62. 2010
    Invasive infections caused by Candida spp. are associated with high mortality. Colonisation by Candida spp. and the capacity of the host to recognise them as potential pathogens are essential steps in the development of these infections...
  40. ncbi Epidemiology of candidemia at a Children's hospital, 2002 to 2006
    Natalie Neu
    Departments of Pediatrics, Columbia University Medical Center, New York, New York, USA
    Pediatr Infect Dis J 28:806-9. 2009
    ..There are few recent studies evaluating trends in the epidemiology of candidemia including changes in species or utilization of antifungal agents in children...
  41. ncbi Changing epidemiology of nosocomial bloodstream infections in 11 teaching hospitals in Taiwan between 1993 and 2006
    Chia Ying Liu
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 43:416-29. 2010
    ..To understand the changing epidemiology of nosocomial bloodstream infections (BSI) in Taiwan, we retrospectively collected nosocomial infection data from 11 hospitals and examined the trends and changing patterns of nosocomial BSI...
  42. ncbi Purification and germination of Candida albicans and Candida dubliniensis chlamydospores cultured in liquid media
    Francesco Citiulo
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, University of Dublin, Dublin 2, Ireland
    FEMS Yeast Res 9:1051-60. 2009
    b>Candida albicans and Candida dubliniensis are the only Candida sp. that have been observed to produce chlamydospores. The function of these large, thick-walled cells is currently unknown...
  43. ncbi Development of thermostable Candida antarctica lipase B through novel in silico design of disulfide bridge
    Quang Anh Tuan Le
    Department of Chemical Engineering, Kwangwoon University, Seoul 139 701, Republic of Korea
    Biotechnol Bioeng 109:867-76. 2012
    Lipase B from Candida antarctica (CalB) is a versatile biocatalyst for various bioconversions. In this study, the thermostability of CalB was improved through the introduction of a new disulfide bridge...
  44. ncbi Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients
    Theo S Plantinga
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 49:724-32. 2009
    ..Dectin-1, a C-type lectin that recognizes 1,3-beta-glucans from fungal pathogens, including Candida species, is involved in the initiation of the immune response against fungi. Methods...
  45. pmc Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei
    Chiatogu Onyewu
    Departments of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 47:956-64. 2003
    ..We recently established that the protein phosphatase calcineurin allows survival of Candida albicans during the membrane stress exerted by azoles...
  46. ncbi Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization
    A C D Delgado
    Infectious Diseases Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil
    Clin Microbiol Infect 15:364-71. 2009
    The objective of this study was to evaluate Candida oral colonization in human immunodeficiency virus (HIV)-infected patients undergoing long-term highly active antiretroviral therapy (ARV)...
  47. pmc Purification, characterization, gene cloning, and expression of a novel alcohol dehydrogenase with anti-prelog stereospecificity from Candida parapsilosis
    Yao Nie
    Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Southern Yangtze University, Wuxi 214122, People s Republic of China
    Appl Environ Microbiol 73:3759-64. 2007
    An alcohol dehydrogenase from Candida parapsilosis CCTCC M203011 was characterized along with its biochemical activity and structural gene...
  48. ncbi Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea
    Sook In Jung
    Chonnam National University Medical School, Gwangju, South Korea
    Med Mycol 48:669-74. 2010
    Multicenter data on in vitro susceptibility of Candida bloodstream isolates to echinocandin antifungal agents is still lacking in South Korea...
  49. pmc Biofilm formation by and antifungal susceptibility of Candida isolates from urine
    N Jain
    Department of Medicine and Microbiology and Immunology, Ullmann 1223, 1300 Morris Park Ave, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Appl Environ Microbiol 73:1697-703. 2007
    ..We determined BF and MIC to antifungals in Candida spp...
  50. ncbi Candida in oral lichen planus patients undergoing topical steroid therapy
    Aree Jainkittivong
    Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:61-6. 2007
    To determine the incidence, intensity, and species of Candida in the oral cavity of oral lichen planus (OLP) patients who were being treated with a topical steroid.
  51. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance study, 1997 to 2005: an 8.5-year analysis of susceptibilities of Candida species and other yeast species to fluconazole and voriconazole determined by CLSI standardized disk diffusion testing
    M A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1735-45. 2007
    ..Overall, 90.1% of all Candida isolates tested were susceptible (S) to fluconazole; however, 10 of the 22 species identified exhibited decreased ..
  52. ncbi Differential regulation of the transcriptional repressor NRG1 accounts for altered host-cell interactions in Candida albicans and Candida dubliniensis
    Gary P Moran
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, University of Dublin, Dublin 2, Republic of Ireland
    Mol Microbiol 66:915-29. 2007
    b>Candida dubliniensis is genetically closely related to Candida albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C...
  53. pmc Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program
    Rana A Hajjeh
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 42:1519-27. 2004
    To determine the incidence of Candida bloodstream infections (BSI) and antifungal drug resistance, population-based active laboratory surveillance was conducted from October 1998 through September 2000 in two areas of the United States (..
  54. pmc Comparison of the broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing with the 24-hour CLSI BMD method for testing susceptibility of Candida species to fluconazole, posaconazole, and voriconazole by use of ep
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 49:845-50. 2011
    ..BMD method M27-A3 for fluconazole, posaconazole, and voriconazole susceptibility testing of 1,056 isolates of Candida. The isolates were obtained in 2009 from more than 60 centers worldwide and included 560 isolates of C...
  55. ncbi Morphological and ecological similarities: wood-boring beetles associated with novel xylose-fermenting yeasts, Spathaspora passalidarum gen. sp. nov. and Candida jeffriesii sp. nov
    Nhu H Nguyen
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA70803, USA
    Mycol Res 110:1232-41. 2006
    ..Here we describe the new yeast genus Spathaspora, the type species S. passalidarum, and its sister taxon Candida jeffriesii and discuss their natural history, including a comparison with Pichia stipitis, another member of a ..
  56. pmc Candida orthopsilosis and Candida metapsilosis spp. nov. to replace Candida parapsilosis groups II and III
    Arianna Tavanti
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    J Clin Microbiol 43:284-92. 2005
    Two new species, Candida orthopsilosis and C. metapsilosis, are proposed to replace the existing designations of C. parapsilosis groups II and III, respectively. The species C. parapsilosis is retained for group I isolates...
  57. ncbi Invasive fungal infections in the intensive care unit: a multicentre, prospective, observational study in Italy (2006-2008)
    Anna Maria Tortorano
    Dipartimento Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Italy
    Mycoses 55:73-9. 2012
    ..A total of 384 fungal infections (318 invasive Candida infections, three cryptococcosis and 63 mould infections) were notified. The median rate of candidaemia was 10...
  58. pmc Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements
    Stanislava Gunisova
    Department of Genetics, Comenius University, Bratislava, Slovak Republic
    RNA 15:546-59. 2009
    ..yeast species with relatively large (>20 base pairs) and nonvariant telomeric repeats, mostly from the genus Candida. Interestingly, several of the TERs reported here are longer than all other yeast TERs known to date...
  59. pmc Differential filamentation of Candida albicans and Candida dubliniensis Is governed by nutrient regulation of UME6 expression
    Leanne O'Connor
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental School and Hospital, Trinity College Dublin, University of Dublin, Dublin 2, Republic of Ireland
    Eukaryot Cell 9:1383-97. 2010
    b>Candida dubliniensis is closely related to Candida albicans; however, it is responsible for fewer infections in humans and is less virulent in animal models of infection. C...
  60. ncbi Risk factors for Candida species colonization of neonatal intensive care unit patients
    L Saiman
    Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 20:1119-24. 2001
    BACKGROUND: Candida spp. are increasingly important pathogens in neonatal intensive care units (NICU)...
  61. ncbi Animal models in the analysis of Candida host-pathogen interactions
    Louis de Repentigny
    Department of Microbiology and Immunology, Sainte Justine Hospital and University of Montreal, 3175 Cote Ste Catherine, Montreal, Quebec, Canada, H3T 1C5
    Curr Opin Microbiol 7:324-9. 2004
    ..Cause-and-effect analysis of Candida host-pathogen interactions using these animal models has made a quantum leap forward in the genomic era, with the ..
  62. pmc Real-time identification of bacteria and Candida species in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    Agnes Ferroni
    Laboratoire de Microbiologie, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, and Université René Descartes Paris 5, Faculte de Medecine, 149 rue de Sevres, 75015 Paris, France
    J Clin Microbiol 48:1542-8. 2010
    ..MALDI-TOF-MS is currently the fastest technique to accurately identify microorganisms grown in positive blood culture broths...
  63. pmc Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Clin Microbiol 48:1366-77. 2010
    Fluconazole in vitro susceptibility test results for 256,882 isolates of Candida spp. were collected from 142 sites in 41 countries from June 1997 to December 2007...
  64. ncbi Community lifestyle of Candida in mixed biofilms: a mini review
    Z M Thein
    Oral Biosciences, Faculty of Dentistry, University of Hong Kong, Prince Philip Dental Hospital, Hong Kong
    Mycoses 52:467-75. 2009
    b>Candida is the most common human fungal pathogen that causes a variety of afflictions from superficial mucosal infections to deep mycoses...
  65. ncbi Attributable mortality of nosocomial candidemia, revisited
    Olafur Gudlaugsson
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, USA
    Clin Infect Dis 37:1172-7. 2003
    ..Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone...
  66. pmc In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species
    Francesca Mondello
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    BMC Infect Dis 6:158. 2006
    ..Thus, the aim of our study was to investigate the in vitro and the in vivo anti-Candida activity of two critical bioactive constituents of TTO, terpinen-4-ol and 1,8-cineole.
  67. ncbi Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimi
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 69:45-50. 2011
    ..The echinocandins displayed excellent potency against both Candida spp. and Aspergillus fumigatus in 2009 samples...
  68. pmc Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering
    Dwight Kuo
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Genome Biol 11:R77. 2010
    ..which yeasts can respond to anti-fungals, we compared gene expression patterns across three evolutionarily distant species - Saccharomyces cerevisiae, Candida glabrata and Kluyveromyces lactis - over time following fluconazole exposure.
  69. ncbi Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp
    H Wisplinghoff
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Clin Microbiol Infect 12:170-7. 2006
    b>Candida spp. are an important cause of nosocomial bloodstream infection (nBSI) and are associated with significant morbidity and mortality...
  70. pmc One year prospective survey of Candida bloodstream infections in Scotland
    Frank C Odds
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Med Microbiol 56:1066-75. 2007
    ..b>Candida albicans was the infecting species in 50 % of cases, followed by Candida glabrata (21 %) and Candida parapsilosis ..
  71. pmc Production, purification, and characterization of a highly glucose-tolerant novel beta-glucosidase from Candida peltata
    B C Saha
    Fermentation Biochemistry Research Unit, U S Department of Agriculture, Peoria, Illinois 61604, USA
    Appl Environ Microbiol 62:3165-70. 1996
    b>Candida peltata (NRRL Y-6888) produced beta-glucosidase when grown in liquid culture on various substrates (glucose, xylose, L-arabinose, cellobiose, sucrose, and maltose)...
  72. ncbi Biofilms and their role in the resistance of pathogenic Candida to antifungal agents
    Christophe d'Enfert
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC 2019, Institut Pasteur, Paris, France
    Curr Drug Targets 7:465-70. 2006
    Fungal pathogens of the genus Candida form biofilms on catheters and prosthetic devices...
  73. ncbi Microbiological aspects of diaper dermatitis
    G Ferrazzini
    Paediatric Practice, Zurich, Switzerland
    Dermatology 206:136-41. 2003
    ..The microbiological basis of diaper dermatitis is not clearly elucidated, although a better knowledge of microbial colonisation can be of importance with regard to an adequate treatment...
  74. ncbi Epidemiology of oral yeast colonization and infection in patients with hematological malignancies, head neck and solid tumors
    Silke Schelenz
    Department of Microbiology, Norfolk and Norwich University Hospital, Norwich, UK
    J Oral Pathol Med 40:83-9. 2011
    ..The aim of this study was to investigate the epidemiology of oral yeast colonization and infection amongst cancer patients...
  75. ncbi Epidemiology of Candida albicans infections and role of non-Candida-albicans yeasts
    Markus Ruhnke
    Medizinische Klinik und Poliklinik II, Charité Campus Mitte der Humboldt Universität zu Berlin, Schumannstrabe 20 21, 10117 Berlin, Germany
    Curr Drug Targets 7:495-504. 2006
    Infections of the skin and the mucous membranes due to Candida species may occur either in immuncompromised or in non-immuncompromised patients. This is in contrast to systemic candidiasis (e.g...
  76. pmc Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients
    Olivier Lortholary
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Antimicrob Agents Chemother 55:532-8. 2011
    ..effect of recent exposure to fluconazole (n = 159) or caspofungin (n = 61) on the proportions of the five major Candida species...
  77. ncbi Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans
    Derek J Sullivan
    Microbiology Research Unit, Department of Oral Medicine, Oral Surgery and Oral Pathology, Dublin Dental School and Hospital, University of Dublin, Trinity College, Dublin 2, Ireland
    FEMS Yeast Res 4:369-76. 2004
    b>Candida dubliniensis is a pathogenic yeast species that was first identified as a distinct taxon in 1995. Epidemiological studies have shown that C...
  78. pmc Telomeric circles: universal players in telomere maintenance?
    Lubomir Tomaska
    Department of Genetics, Comenius University in Bratislava, Faculty of Natural Sciences, Bratislava, Slovakia
    Nat Struct Mol Biol 16:1010-5. 2009
    ..In this Perspective, we summarize these findings and discuss how t-circles may be related to t-loops and how t-circles may have initiated the evolution of telomeres...
  79. ncbi Risk factors for candidemia in Neonatal Intensive Care Unit patients. The National Epidemiology of Mycosis Survey study group
    L Saiman
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Pediatr Infect Dis J 19:319-24. 2000
    b>Candida species are important nosocomial pathogens in neonatal intensive care unit (NICU) patients.
  80. ncbi Management and outcome of bloodstream infections due to Candida species in England and Wales
    C C Kibbler
    Department of Medical Microbiology, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    J Hosp Infect 54:18-24. 2003
    ..0/100,000 bed days and 45.4% cases occurred in intensive care unit (ICU) patients. Candida albicans was isolated in 64.7% of confirmed cases...
  81. ncbi Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance
    V Krcmery
    University of Trnava, School of Public Health, Department of Pharmacology, 91743 Trnava, SK
    J Hosp Infect 50:243-60. 2002
    Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population...
  82. pmc Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study
    D J Diekema
    Division of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Microbiol 40:1298-302. 2002
    Bloodstream infections due to Candida species cause significant morbidity and mortality. Surveillance for candidemia is necessary to detect trends in species distribution and antifungal resistance...
  83. ncbi Evaluation of amniotic fluid cytokines in preterm labor and intact membranes
    Reinaldo Figueroa
    Department of Obstetrics, Cell Biology and Anatomy, New York Medical College, Valhalla, NY 11501, USA
    J Matern Fetal Neonatal Med 18:241-7. 2005
    ....
  84. ncbi Candida parapsilosis: a review of its epidemiology, pathogenesis, clinical aspects, typing and antimicrobial susceptibility
    Eveline C van Asbeck
    Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, CA 95128, USA
    Crit Rev Microbiol 35:283-309. 2009
    The Candida parapsilosis family has emerged as a major opportunistic and nosocomial pathogen. It causes multifaceted pathology in immuno-compromised and normal hosts, notably low birth weight neonates...
  85. ncbi Pathogenicity and virulence of Candida dubliniensis: comparison with C. albicans
    M M S Vilela
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Inohana, Japan
    Med Mycol 40:249-57. 2002
    b>Candida dubliniensis is a newly described fungus that is frequently isolated from the oral cavities of HIV-positive patients. Although extensive studies have been performed on the phylogeny of C...
  86. ncbi Phospholipidome of Candida: each species of Candida has distinctive phospholipid molecular species
    Ashutosh Singh
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    OMICS 14:665-77. 2010
    ..ionization tandem mass spectrometry (ESI-MS/MS), the phospholipidomes of eight hemiascomycetous human pathogenic Candida species have been characterized. Over 200 phospholipid molecular species were identified and quantified...
  87. pmc Evolution of mating within the Candida parapsilosis species group
    Sixiang Sai
    UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Eukaryot Cell 10:578-87. 2011
    b>Candida orthopsilosis and Candida metapsilosis are closely related to Candida parapsilosis, a major cause of infection in premature neonates. Mating has not been observed in these species. We show that ∼190 isolates of C...
  88. ncbi Antifungal activity of silver nanoparticles against Candida spp
    Ales Panacek
    Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc 771 46, Czech Republic
    Biomaterials 30:6333-40. 2009
    ..activity of the silver nanoparticles (NPs) prepared by the modified Tollens process was evaluated for pathogenic Candida spp...
  89. ncbi Antioxidant system within yeast peroxisome. Biochemical and physiological characterization of CbPmp20 in the methylotrophic yeast Candida boidinii
    H Horiguchi
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 276:14279-88. 2001
    b>Candida boidinii Pmp20 (CbPmp20), a protein associated with the inner side of peroxisomal membrane, belongs to a recently identified protein family of antioxidant enzymes, the peroxiredoxins, which contain one cysteine residue...
  90. ncbi Differential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?
    Derek J Sullivan
    Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Ireland
    Virulence 2:77-81. 2011
    b>Candida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C...
  91. ncbi Anti-Candida activity of essential oils
    A Palmeira-de-Oliveira
    Health Sciences Research Center, University of Beira Interior, Covilha, Portugal
    Mini Rev Med Chem 9:1292-1305. 2009
    Anti-Candida activity of essential oils has been widely studied and as a consequence they are being investigated as possible alternatives or complementary therapeutic agents for candidosis...
  92. ncbi Efficient production of active recombinant Candida rugosa LIP3 lipase in Pichia pastoris and biochemical characterization of the purified enzyme
    Shu Wei Chang
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung
    J Agric Food Chem 54:5831-8. 2006
    b>Candida rugosa lipase (CRL), an important industrial enzyme, possesses several different isoforms encoded by the high-identity lip gene family (lip1 to lip7)...
  93. ncbi Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study
    Saad Nseir
    Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037, Lille Cedex, France
    Intensive Care Med 33:137-42. 2007
    A pathogenic interaction between Candida albicans and Pseudomonas aeruginosa has recently been demonstrated. In addition, experimental and clinical studies identified Candida spp. tracheobronchial colonization as a risk factor for P...
  94. ncbi Invasive fungal infections: the challenge continues
    Antonino Gullo
    Department and School of Anesthesia and Intensive Care, Catania University Hospital, University of Catania, Italy
    Drugs 69:65-73. 2009
    ..They can range widely in severity and can be life threatening in some patients. Candida and Aspergillus species are the most common causes of IFIs, but other yeasts and filamentous fungi are emerging ..
  95. ncbi Differentiation of Candida albicans and Candida dubliniensis using a single-enzyme PCR-RFLP method
    Hossein Mirhendi
    Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Jpn J Infect Dis 58:235-7. 2005
    b>Candida dubliniensis is a novel Candida spp. that is similar to Candida albicans with respect to several phenotypic characteristics...
  96. ncbi Slime production and proteinase activity of Candida species isolated from blood samples and the comparison of these activities with minimum inhibitory concentration values of antifungal agents
    Semiha Ozkan
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Mem Inst Oswaldo Cruz 100:319-23. 2005
    Slime and proteinase activity of 54 strains consisting of 19 Candida parapsilosis and 35 C. albicans strains isolated from blood samples were investigated in this study...
  97. ncbi Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    FEMS Microbiol Rev 34:1063-75. 2010
    Infections caused by Candida spp. continue to be a substantial cause of disease burden, especially in immunocompromised patients...
  98. pmc Nationwide sentinel surveillance of bloodstream Candida infections in 40 tertiary care hospitals in Spain
    R Cisterna
    Basurto Hospital, Clinical Microbiology and Infection Control Department, Bilbao, Spain
    J Clin Microbiol 48:4200-6. 2010
    ..assess the incidence, species distribution, frequency of antifungal resistance, and risk factors for acquiring a Candida infection...
  99. ncbi Characterization of biofilms formed by Candida parapsilosis, C. metapsilosis, and C. orthopsilosis
    Ali Abdul Lattif
    Center for Medical Mycology, Department of Dermatology, University Hospital s Case Medical Center, and Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106 502, USA
    Int J Med Microbiol 300:265-70. 2010
    Infections due to Candida parapsilosis have been associated with the ability of this fungus to form biofilms on indwelling medical devices. Recently, C. parapsilosis isolates were reclassified into 3 genetically non-identical classes: C...
  100. ncbi Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study
    P Manzoni
    Neonatology and Hospital Neonatal Intensive Care Unit, Azienda Ospedaliera Regina Margherita S Anna, Turin, Italy
    Clin Infect Dis 42:1735-42. 2006
    Colonization by Candida species is the most important predictor of the development of invasive fungal disease in preterm neonates, and the enteric reservoir is a major site of colonization...
  101. ncbi Detection of Candida species by PCR in self-collected vaginal swabs of women after taking antibiotics
    Sepehr N Tabrizi
    Mycoses 49:523-4. 2006
    ..This study evaluated polymerase chain reaction (PCR) for the detection of Candida species in comparison with the conventional laboratory culture methods in samples from women with and without ..

Research Grants77

  1. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    b>Candida albicans is a commensal member of the human microflora and is the most common causative agent of fungal-related disease with particular significance in immuno-compromised individuals with HIV disease/AIDS, ranging from mild ..
  2. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..Escherichia coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida albicans also demonstrate an electricidal effect.} We have shown that electrical current is active against S...
  3. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..We now have access to Candida albicans that has been genetically engineered to express Gaussia princeps luciferase and Aspergillus fumigates ..
  4. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..coli flavohemoglobin and a series of fungal (Candida albicans and Aspergillus fumigatus) flavohemoglobins, which catalyze this reaction as part of a defense mechanism ..
  5. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..b>Candida albicans was also recently discovered to undergo same-sex mating, and cryptic sexual cycles are being found for ..
  6. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    b>Candida albicans is a widespread human fungal pathogen that causes high rates of mortality during systemic infections (candidiasis)...
  7. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..Fungal keratitis is predominantly caused by filamentous fungi Fusarium, but yeasts (e.g. Candida) can also cause this disease...
  8. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..Dissemination of primary epithelial Candida infection is associated with a high rate of crude and attributable mortality...
  9. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..last steps of the GlcCer pathway affect fungal pathogenesis not only of fungi infecting humans, such as Cn3, 4, Candida albicans5-7, and Aspergillus fumigatus8, but also of fungi infecting plants, such as Fusarium graminearum9...
  10. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..b>Candida albicans is the most common human fungal pathogen, causing both mucosal and systemic infections and remains a ..
  11. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..is to investigate the effects of cannabinoids (THC and 2-arachidonoylglycerol (2-AG)) and CB2R on a systemic Candida albicans (C. albicans) infection. C...
  12. Centromere Structure and Function in Candida albicans
    Judith G Berman; Fiscal Year: 2012
    b>Candida albicans is an important human fungal pathogen that causes superficial mucosal and lethal systemic infections. Prophylactic antifungal treatments often result in the appearance of acquired drug resistance. C...
  13. Genetic and Evolutionary Basis of Fungal Drug Resistance
    Zhenglong Gu; Fiscal Year: 2013
    ..cerevisiae and in a pathogenic yeast species, Candida albicans. The function and evolution of other genes identified in Aim 1 will also be investigated...
  14. MT VET COBRE II CORE A: ADMINISTRATIVE CORE
    Mark T Quinn; Fiscal Year: 2011
    ..Dr. Perfect's research team investigates anti-fungal agents in animal models of Candida and Cryptococcus infections. The EAC met with the EC by phone conference once this reporting year...
  15. RNA CONFORMATION AND CATALYSIS
    David P Bartel; Fiscal Year: 2013
    ..cerevisiae) and Candida albicans (a common human pathogen)...
  16. Enzymology of Post-translational Modifications
    Carol A Fierke; Fiscal Year: 2013
    ..Here, we propose to: (1) investigate determinants of prenyltransferase substrate specificity for mammalian and Candida albicans enzymes and analyze the effects of individual prenylation pathway modifications on protein localization ..
  17. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida species are the most important fungal pathogens of humans, and Candida albicans, in particular, is the most common cause of oropharyngeal candidiasis, which is an infection that affects ..
  18. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..e. Mycobacterium tuberculosis, Listeria monocytogenes) and other fungi (i.e. Cryptococcus neoformans, Candida albicans) demonstrates that specific antibody can improve the ability of the host to combat these infecting ..
  19. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    ..and render resistance to a broad spectrum of keratitis causing pathogens, including Pseudomonas aeruginosa, Candida albicans and Aspergillus fumigates...
  20. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..experiments show A[unreadable] inhibits the growth of eight clinically important microorganisms, including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria ..
  21. Investigation of the structure and function of urea amidolyase
    MARTIN RAOUL ST. MAURICE; Fiscal Year: 2012
    ..The enzyme activity influences a yeast-to-hyphae switch that allows Candida albicans to escape from macrophages during systemic infections...
  22. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2012
    ..Our research focuses on signaling cascades as targets for antifungal drugs. Studies are proposed on Candida albicans, the most common human fungal pathogen that remains a major mucosal pathogen in AIDS patients who fail ..
  23. Genetics and visualization of innate host response to C. albicans infection in vi
    Robert T Wheeler; Fiscal Year: 2012
    ..b>Candida albicans is a ubiquitous commensal and the most frequent cause of fungal disease in humans...
  24. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..Hospital-acquired infections occur in ~10% of the patients in critical care facilities in the US, and Candida species are currently the 4th leading cause of blood stream infection...
  25. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..We will test several microorganisms, including gram (+), gram (-), Candida albicans and Chlamydia trachomatis...
  26. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ..In preliminary studies, we found that key components of Candida albicans and Cryptococcus neoformans pathogenesis in mammals are also involved in nematode killing...
  27. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2013
    ..glabrata. PUBLIC HEALTH RELEVANCE: The ability of Candida glabrata, an important yeast pathogen, to cause disease is not well understood...
  28. N-acetylglucosamine signaling in fungi
    James B Konopka; Fiscal Year: 2012
    ..GlcNAc also stimulates the human fungal pathogen Candida albicans to induce the expression of virulence factors, including a switch from budding to hyphal growth...
  29. Novel antifungals for Immunocompromised/HIV patients.
    ESTEBAN EDWARD MENA; Fiscal Year: 2011
    ..screening LifePharms'natural product library against both fluconazole sensitive (ATCC 90028) and resistant Candida strains ATCC 90030, 96901, 6852) and Aspergillus fumigatus and Cryptococcus neoformans...
  30. Identifying novel small molecules for improved antifungal drug treatment
    Martha L Bulyk; Fiscal Year: 2012
    ..Infections caused by pathogenic Candida species are especially prevalent, affecting nearly one in fifty intensive care unit patients and causing nearly ..
  31. Identification of broad-spectrum antifungal efflux pump inhibitors
    Richard Cannon; Fiscal Year: 2009
    ..be applicable to the panel of yeast strains expressing efflux pumps from the following clinically relevant fungi: Candida albicans, Candida glabrata, Candida krusei and Cryptococcus neoformans...
  32. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..for improved drug delivery systems to the brain;and David Soll evaluates factors of pathogenicity in the yeast, Candida albicans, the frequent underlying reason of opportunistic infections in immunosuppressed patients...
  33. Benzophenones: Novel natural agents which inhibits HIV and Candida
    Ramiro Mendonca Murata; Fiscal Year: 2013
    ..However, the mechanism(s) of action of benzophenoes against both HIV and opportunistic infections, including Candida, has yet to be determined...
  34. Benzophenones: Novel natural agents which inhibits HIV and Candida
    Ramiro Mendonca Murata; Fiscal Year: 2011
    ..However, the mechanism(s) of action of benzophenoes against both HIV and opportunistic infections, including Candida, has yet to be determined...
  35. Extracellular pH modulation by Candida albicans in vitro and in vivo
    Michael C Lorenz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida albicans is the most important human-associated fungus, existing as both an integral component of the microbiota and as a pathogen of multiple organ systems. C...
  36. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..b>Candida albicans, a common opportunistic fungal pathogen, is the leading cause of invasive fungal disease in ..
  37. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
    ..plays a particularly important role in controlling mucocutaneous fungal infections caused by the commensal yeast, Candida albicans...
  38. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candida albicans is an opportunistic pathogen that causes oropharyngeal disease in a large and diverse population of patients, including those with HIV/AIDS, Sjogren's syndrome, diabetes ..
  39. Nlrp3 inflammasome signaling in immune responses to Candida albicans
    Fayyaz S Sutterwala; Fiscal Year: 2013
    ..albicans-induced activation of the Nlrp3 inflammasome. We will also identify Candida specific factors expressed during yeast-hyphae transition that are directly sensed by the Nlrp3 inflammasome...
  40. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..For comparison, events associated with ingestion of the yeast Candida albicans via the mannose receptor (MR) will be studied...
  41. The Role of Genetic Variation in the Fungal/Host Interaction
    Gerald R Fink; Fiscal Year: 2012
    ..Pathogenic fungi such as Candida albicans, and the non-pathogen, S...
  42. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    ..Previous work in fungal pathogens such as Candida albicans and Candida glabrata has provided clear implication of gene transcription as a key determinant of drug ..
  43. Virulence factor identification by comparative transcriptomics in Candida species
    Michael C Lorenz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Collectively, the genus Candida is the most important cause of fungal infections in the developed world, responsible for roughly 75% of disseminated or invasive fungal infections...
  44. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel K Benjamin; Fiscal Year: 2012
    ..Invasive candidiasis is diagnosed by positive culture for Candida sp. from normally sterile body fluid...
  45. Analysis of Candida albicans filamentation using SILAC
    DEREK PAUL THOMAS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pathogenic potential of Candida albicans is intimately related with the way this organism senses and reacts to its surrounding environment, which, in the case of C. albicans, is the host...
  46. NEONATAL CANDIDIASIS &IMMUNE COMPROMISE DURING DEVELOPMENT
    JOSEPH MARK BLISS; Fiscal Year: 2011
    ..Specific Aim 3 will take advantage of a unique susceptibility of neonates to infection with another Candida species, C. parapsilosis, to better define the response of neutrophils to a fungal pathogen...
  47. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Scott Moye-Rowley; Fiscal Year: 2013
    ..cerevisiae) that efflux drugs out of the cell. The pathogenic Candida species, Candida albicans and Candida glabrata, express homologues of ScPdr5 and can acquire similar multidrug ..
  48. A Structural Approach for Treating Drug Resistant Fungal Pathogens
    Mitchell W Mutz; Fiscal Year: 2013
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate...
  49. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ..b>Candida albicans causes both mucosal and disseminated disease...
  50. Genetic Heterogeniety of the Hyper IgE Syndrome
    TALAL AMINE CHATILA; Fiscal Year: 2010
    ..Patients are particularly susceptible to Staphylococcus aureus and Candida albicans, and suffer from skin abscesses, pneumonia with pneumatocele formation, and other deep-seated infections...
  51. Innate Immune Recognition of Candida albicans Infection in a C. elegans Model
    Read Pukkila-Worley; Fiscal Year: 2013
    ..b>Candida albicans is found in the intestine of virtually all healthy humans...
  52. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..ATAK) cells diminishes their replicative capacity and markedly increases the efficiency with which they kill Candida albicans, consistent with the cells'maturation towards mature granulocytes...
  53. Oligonucleotides that Modulate AMPA Receptor Alternative Splicing as Drug Candida
    Gordon J Lutz; Fiscal Year: 2012
    ..We will then use the best delivery modality determined in Aim 1 and evaluate the efficacy of our two lead SMOs to improve motor function, and increase lifespan in ALS mice (Aim 2). ..
  54. Small molecule inhibitors of a Candida albicans histone modifying enzyme
    JESSICA RAMOS LOPES DA ROSA-SPIEGLER; Fiscal Year: 2012
    b>Candida albicans is a widespread human fungal pathogen that causes high rates of mortality during systemic infections, and is particularly dangerous for immunocompromised AIDS patients. Because fungi such as C...
  55. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections
    Mitchell W Mutz; Fiscal Year: 2011
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate...
  56. 11th ASM Conference on Candida and candidiasis
    Scott G Filler; Fiscal Year: 2012
    DESCRIPTION: Candida is the major fungal pathogen of humans, causing diseases that range from oral and vaginal candidiasis to life-threatening candidemia and invasive disease...
  57. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010
    ..genes that require Ess1, (3) Use structure and function analysis to examine enzyme-substrate interactions by Candida albicans Ess1, with the long-term goal of exploiting key differences between the fungal and human enzymes for ..
  58. Synthetic glycopeptide vaccines that enhance resistance to candidiasis
    Hong Xin; Fiscal Year: 2013
    ..Novel fully synthetic peptide and glycopeptide vaccines against Candida albicans cell surface epitopes have been successfully used to combat disseminated candidiasis in mice in our lab...
  59. Can Sexually Transmitted Pathogens Impact the Efficacy of HIV-1 Microbicides?
    SUSANA NOEMI ASIN; Fiscal Year: 2013
    ..Specific Aim 2 will explore TLR-dependent immunological mechanisms by which HSV-2, Neisseria gonorrhoeae, and Candida albicans modulate the efficacy of lead microbicides...
  60. Mechanisms of Host Adaptation for Candida albicans
    PETER JOHN ESPENSHADE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The obligate commensal organism Candida albicans colonizes the intestinal tract of its human host, and normally causes no disease...
  61. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel H Kaplan; Fiscal Year: 2013
    ..we will generate an antigen-specific infection model by combining an existing model of cutaneous Candidiasis with Candida albicans that we will engineer to express ovalbumin...
  62. MICROBICIDAL SALIVARY HISTIDINE-RICH PROTEINS
    Frank G Oppenheim; Fiscal Year: 2012
    ..A major focus of investigation is the antifungal effect of histatins on the oral pathogen Candida albicans, causing the most frequently occurring oral fungal infection...
  63. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..Specifically, a 15-20 min exposure of Candida albicans, Candida krusei, or Saccharomyces cerevisiae to certain drugs (including the antifungal azoles ..
  64. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Candida species have become among the most common causes of nosocomial infections in the United States and worldwide...
  65. SEEKING THE YEAST SPARKING STEROL
    Martin Bard; Fiscal Year: 1991
    Opportunistic fungal pathogens, particularly Candida albicans, are a more serious problem as a result of the increasing number of immunocompromised individuals (cancer patients and AIDS victims)...
  66. FIBRONECTIN RECEPTOR IN CANDIDA TROPICALIS
    MARGARET HOSTETTER; Fiscal Year: 2003
    Among Candida species, Candida tropicalis ranks second only to Candida albicans as a cause or morbidity and mortality among immunocompromised hosts, especially in patients undergoing cancer chemotherapy or those with fungal endocarditis...
  67. Immunity to Oral Candidiasis
    SARAH GAFFEN; Fiscal Year: 2009
    ..Oropharyngeal candidiasis (OPC), caused by the yeast Candida albicans, is a major disease associated with immunosuppression due to chemotherapy, AIDS or congenital ..
  68. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Candida-associated denture stomatitis (chronic atrophic candidiasis) is the most prevalent superficial oral infection and the most common form of Candida-associated disease...
  69. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    ..b>Candida albicans, the primary cause of candidosis, is a member of the normal flora and grows either in yeast of hyphal ..
  70. Rechargeable Long-term Antifungal Denture Materials
    Yuyu Sun; Fiscal Year: 2009
    ..provided by applicant): Project Summary: Using antifungal dentures is an attractive approach to manage Candida-associated denture stomatitis (CADS), a common recurring disease among denture wearers, particularly in those who ..
  71. Glucan Binding to Azole Drugs: A Novel Resistance Mechanism in Candida albicans
    THEODORE WHITE; Fiscal Year: 2009
    Project Summary The pathogenic yeast Candida albicans (Ca) is a frequent cause of oral and systemic fungal infections in immune-compromised people and of vaginal infections in women...
  72. P-113: a novel peptide therapy for vaginal candidiasis
    David Osborne; Fiscal Year: 2005
    ..VC is caused by an overgrowth of endogenous Candida species, many resistant to mainstream azole antifungal therapies such as fluconazole...
  73. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Most yeast species including Candida albicans are azole-sensitive...
  74. MOLECULAR MARKER FOR INVASIVE CANDIDA ALBICANS
    MARGARET HOSTETTER; Fiscal Year: 2001
    The opportunistic pathogen Candida albicans adheres to epithelium and replicates at the mucosal barrier prior to invading the bloodstream...
  75. IMMUNE RECOGNITION OF CANDIDA--ROLE OF CELL WALL
    David Williams; Fiscal Year: 2001
    DESCRIPTION (Verbatim from Applicant's Abstract): Pathogenic fungi, such as Candida albicans, are increasingly common as opportunistic pathogens which cause significant morbidity and mortality in the immunocompromised host...
  76. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..We have found that vaccination of mice with r a vaccine to prevent life threatening Candida i Furthermore, infections caused by strains and species resistant to a Candida spp...
  77. Vaccine Strategies for Candidal Infections
    John P Hennessey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Candida species are opportunistic fungal pathogens that have become among the most common causes of nosocomial infections in the United States and worldwide...