Genomes and Genes
Summary: A genus of onygenacetous mitosporic fungi whose perfect state is Ajellomyces (see ONYGENALES). The species Blastomyces dermatitidis (perfect state Ajellomyces dermatitidis) causes blastomycosis.
Publications190 found, 100 shown here
- Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein DMadhavi Lekkala
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
Infect Immun 74:4549-56. 2006..effect of surfactant-associated proteins in bronchoalveolar lavage fluid (BALF) on the interaction of BAM and Blastomyces dermatitidis. We investigated BALF enhancement or inhibition of TNF-alpha production by BAM stimulated by B...
- Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samplesJennifer K Meece
Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield Clinic, Marshfield, Wisconsin 54449, USA dclin edu
Med Mycol 48:285-90. 2010Blastomycosis is a serious and potentially fatal infection caused by the thermally dimorphic fungus Blastomyces dermatitidis...
- Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hostsMarcel Wuthrich
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
J Exp Med 197:1405-16. 2003..dispensable for vaccine-induced resistance against experimental fungal pulmonary infections with two agents, Blastomyces dermatitidis an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular pathogen...
- Population genetic structure of clinical and environmental isolates of Blastomyces dermatitidis, based on 27 polymorphic microsatellite markersJennifer K Meece
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 544491, USA
Appl Environ Microbiol 77:5123-31. 2011b>Blastomyces dermatitidis, a thermally dimorphic fungus, is the etiologic agent of North American blastomycosis...
- Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infectionT Tristan Brandhorst
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
J Immunol 173:7444-53. 2004..BAD1, a virulence factor of Blastomyces dermatitidis, is displayed on yeast and released during infection...
- Cell wall biogenesis of Blastomyces dermatitidis. Evidence for a novel mechanism of cell surface localization of a virulence-associated adhesin via extracellular release and reassociation with cell wall chitinT Brandhorst
Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and the Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
J Biol Chem 275:7925-34. 2000Pathogenic yeast of Blastomyces dermatitidis express a surface protein adhesin, WI-1. Due to the crucial role of WI-1 in adherence and disease pathogenesis, we investigated how the protein localizes to the surface of B. dermatitidis...
- Antigen assay with the potential to aid in diagnosis of blastomycosisMichelle Durkin
MiraVista Diagnostics MiraBella Technologies, Indianapolis, Indiana 46241, USA
J Clin Microbiol 42:4873-5. 2004We report results of an immunoassay for Blastomyces dermatitidis antigenuria. Sensitivity was 92.9%, and specificity was 79.3%. Cross-reactions occurred in 96...
- Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidisT T Brandhorst
Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
J Exp Med 189:1207-16. 1999..In Blastomyces dermatitidis, the agent of blastomycosis, a respiratory and disseminated mycosis of people and animals ..
- Clinical and laboratory update on blastomycosisMichael Saccente
Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 639, Little Rock, AR 72205, USA
Clin Microbiol Rev 23:367-81. 2010..and children because men are more likely to participate in activities that put them at risk for exposure to Blastomyces dermatitidis...
- Ecologic niche modeling of Blastomyces dermatitidis in WisconsinKurt D Reed
Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America
PLoS ONE 3:e2034. 2008Blastomycosis is a potentially fatal mycosis that is acquired by inhaling infectious spores of Blastomyces dermatitidis present in the environment...
- Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophagesB S Klein
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison 53792
Infect Immun 62:3536-42. 1994The molecular basis for pathogenicity and virulence of the dimorphic fungus Blastomyces dermatitidis remains unknown. WI-1 is a major cell wall protein of B...
- Studies on the molecular ecology of Blastomyces dermatitidisD J Baumgardner
Department of Family Medicine, University of Wisconsin Medical School, Milwaukee 53215, USA
Mycopathologia 152:51-8. 2001The microecology of Blastomyces dermatitidis, the dimorphic etiologic agent of the potentially fatal systemic fungal infection, blastomycosis, is not well defined...
- Skeletal muscle abscess caused by Blastomyces dermatitidisConstantine Tsigrelis
Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Am J Med Sci 337:293-4. 2009..We, therefore, report a case of a large gluteal muscle abscess caused by Blastomyces dermatitidis in a young, immunocompetent male...
- Seasonal variations in the clinical presentation of pulmonary and extrapulmonary blastomycosisR Bruce Light
Section of Infectious Diseases, Department of Medicine, University of Manitoba, Winnipeg
Med Mycol 46:835-41. 2008Blastomycosis is a granulomatous infection caused by the thermally dimorphic fungus, Blastomyces dermatitidis, for which seasonal variation has been proposed...
- Blastomycosis in indiana: digging up more casesW Graham Carlos
Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, Indianapolis, IN 46202, USA
Chest 138:1377-82. 2010..We propose that this surge was related to major highway construction around Indianapolis...
- A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidisTristan Brandhorst
Department of Pediatrics, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
Mol Microbiol 48:53-65. 2003BAD1, an adhesin and immune modulator of Blastomyces dermatitidis, is an essential virulence factor that is released extracellularly before association with the yeast surface...
- Purification in quantity of the secreted form of WI-1: a major adhesin on Blastomyces dermatitidis yeastsR Audet
Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
Protein Expr Purif 11:219-26. 1997WI-1, a 120-kDa adhesin on Blastomyces dermatitidis, binds the yeast to macrophages and is a major target antigen of immune recognition in acquired resistance to the fungus...
- African strains of Blastomyces dermatitidis that do not express surface adhesin WI-1B S Klein
Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
Infect Immun 65:1505-9. 1997African strains of Blastomyces dermatitidis differ from North American strains in their growth, morphology, and clinical disease phenotype. In addition, two serotypes, designated 1 and 2, have been described...
- Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidisMarcel Wuthrich
Department of Pediatrics, University Hospital and Clinics, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
J Immunol 176:5538-47. 2006..We explored the role of CD40/CD40L interactions in vaccine immunity to Blastomyces dermatitidis by immunizing CD40(-/-) and CD40L(-/-) mice and analyzing their resistance to reinfection in a ..
- Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeastsL H Hogan
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madision 53792, USA
J Biol Chem 270:30725-32. 1995WI-1 is a 120-kDa surface protein adhesin on Blastomyces dermatitidis yeasts that binds CD18 and CD14 receptors on human macrophages...
- The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14S L Newman
Department of Medicine, University of Cincinnati College of Medicine, OH 45267
J Immunol 154:753-61. 1995Three genetically related strains of Blastomyces dermatitidis (Bd) yeasts that differ in their expression of WI-1, an immunodominant cell wall Ag, were tested for their capacity to bind to human macrophages (M phi) in the absence of ..
- Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidisWenjun Li
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA
Eukaryot Cell 12:109-17. 2013b>Blastomyces dermatitidis is a dimorphic fungal pathogen that primarily causes blastomycosis in the midwestern and northern United States and Canada...
- Blastomycosis: Case report of an isolated lesion in the distal fibulaA Alex Jahangir
Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Orthop (Belle Mead NJ) 39:E22-4. 2010Blastomycosis (Blastomyces dermatitidis) is a fungal infection that occurs primarily in the lungs, but 15% to 60% of patients with systemic blastomycosis have skeletal involvement...
- Global control of dimorphism and virulence in fungiJulie C Nemecek
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Science 312:583-8. 2006..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease...
- Non-rural point source blastomycosis outbreak near a yard waste collection siteJohn R Pfister
Bureau of Communicable Disease and Emergency Response, Wisconsin Division of Public Health, Madison, Wisconsin 53701, USA
Clin Med Res 9:57-65. 2011Blastomycosis is a potentially fatal infection caused by the fungus Blastomyces dermatitidis...
- Molecular genetic analysis of Blastomyces dermatitidis reveals new insights about pathogenic mechanismsT Tristan Brandhorst
Departments of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
Int J Med Microbiol 292:363-71. 2002..Advances in the molecular tools for genetic manipulation of Blastomyces dermatitidis have enhanced our ability to study this poorly understood dimorphic fungal pathogen...
- Purification and characterization of the major antigen WI-1 from Blastomyces dermatitidis yeasts and immunological comparison with A antigenB S Klein
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison
Infect Immun 62:3890-900. 1994The lack of well-defined antigens from Blastomyces dermatitidis has hampered the ability to reliably diagnose human infection and study the immunobiology of blastomycosis. We recently discovered a novel surface protein on B...
- Effects of season and weather on blastomycosis in dogs: Northern Wisconsin, USADennis J Baumgardner
Department of Family Medicine, Aurora UW Medical Group, University of Wisconsin School of Medicine and Public Health, Center for Urban Population Health, Milwaukee, USA
Med Mycol 49:49-55. 2011Dogs and humans acquire Blastomyces dermatitidis infections from the same incompletely defined habitat. Studies of blastomycosis cases have not consistently demonstrated seasonality or significant antecedent climate effects...
- Clinical aspects of natural infection with Blastomyces dermatitidis in cats: 8 cases (1991-2005)Chen Gilor
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
J Am Vet Med Assoc 229:96-9. 2006..To evaluate clinical and laboratory findings, treatment, and clinical outcome in cats with blastomycosis...
- Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis)L Sigler
University of Alberta Microfungus Collection and Herbarium, Edmonton, Canada
J Med Vet Mycol 34:303-14. 1996..Phenotypic similarities between Emmonsia spp. and Blastomyces dermatitidis and chance observation of Ajellomyces-type ascomatal hyphae led to the hypothesis that the ..
- Variation in clinical phenotype of human infection among genetic groups of Blastomyces dermatitidisJennifer K Meece
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
J Infect Dis 207:814-22. 2013b>Blastomyces dermatitidis, the etiologic agent of blastomycosis, has 2 genetic groups and shows varied clinical presentation, ranging from silent infections to fulminant respiratory disease and dissemination...
- Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidisT Tristan Brandhorst
Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
J Biol Chem 280:42156-63. 2005BAD-1 (Blastomyces adhesin 1), a 120-kDa protein of Blastomyces dermatitidis, functions as an adhesin, immune modulator, and essential virulence factor...
- Defining virulence genes in the dimorphic fungiChad A Rappleye
Department of Microbiology, Ohio State University, Columbus, Ohio 43210, USA
Annu Rev Microbiol 60:281-303. 2006..Thus, the stage is set and the tools are in place for the next phase of medical mycology research: defining the virulence-associated factors underlying the success of dimorphic fungal pathogens...
- Cutaneous inoculation blastomycosisNathan A Gray
Section of Infectious Diseases, Department of Medicine, Graduate School of Medicine, University of Tennessee Medical Center at Knoxville, Knoxville, TN 37920, USA
Clin Infect Dis 34:E44-9. 2002..We also review cases of cutaneous inoculation blastomycosis described elsewhere, to improve characterization of the syndrome...
- BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanismsBeatriz Finkel-Jimenez
Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792
J Immunol 168:5746-55. 2002We investigated how BAD1, an adhesin and virulence factor of Blastomyces dermatitidis, suppresses phagocyte proinflammatory responses...
- Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hostsMarcel Wuthrich
Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
J Immunol 169:6969-76. 2002..Vaccination with a genetically engineered, live, attenuated strain of Blastomyces dermatitidis carrying a targeted deletion at the BAD1 locus confers sterilizing immunity against experimental ..
- V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidisMarcel Wuthrich
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
Infect Immun 75:193-200. 2007Immunization with a cell wall/membrane (CW/M) and yeast cytosol extract (YCE) crude antigen from Blastomyces dermatitidis confers T-cell-mediated resistance against lethal experimental infection in mice...
- Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidisM Wuthrich
Departments of Pediatrics, Internal Medicine, Medical Microbiology and Immunology, Comprehensive Cancer Center, University of Wisconsin Medical School, Hospitals and Clinics, Madison, WI 53792, USA
Infect Immun 66:5443-9. 1998People infected with Blastomyces dermatitidis develop strong immunity to the yeast surface adhesin WI-1, including antibody responses to the adhesive domain, a 25-amino-acid repeat, and cellular responses to the N terminus...
- Pulmonary blastomycosis: a great masqueraderJeanne Wallace
Chest 121:677-9. 2002
- Nested PCR assays for detection of Blastomyces dermatitidis DNA in paraffin-embedded canine tissueRalf Bialek
Institute for Tropical Medicine, University Hospital Tubingen, Tubingen, Germany
J Clin Microbiol 41:205-8. 2003A Blastomyces dermatitidis nested PCR assay targeting the gene encoding the Wisconsin 1 (WI-1) adhesin was developed and compared with a nested PCR targeting the 18S rRNA gene (rDNA) of members of the family ONYGENACEAE: We examined 73 ..
- Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellaniiJudith N Steenbergen
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 72:3478-88. 2004..Yeast forms of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum were each ingested by amoebae and macrophages, ..
- Sequence elements necessary for transcriptional activation of BAD1 in the yeast phase of Blastomyces dermatitidisPeggy J Rooney
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI 53792, USA
Eukaryot Cell 3:785-94. 2004b>Blastomyces dermatitidis is a dimorphic fungal pathogen that converts from mycelia or conidia to a host-adapted yeast morphotype upon infection. Conversion to the yeast form is accompanied by the production of the virulence factor BAD1...
- Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidisAdi Koneti
California Institute for Medical Research and Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
Infect Immun 76:994-1002. 2008..Little is known about the effects of serum factors or MBL on the interaction of Blastomyces dermatitidis, a pulmonary fungal pathogen, with macrophages or on tumor necrosis factor alpha (TNF-alpha) ..
- The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidisB Finkel Jimenez
Department of Pediatrics, Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, USA
J Immunol 166:2665-73. 2001The WI-1 adhesin is indispensable for pathogenicity of Blastomyces dermatitidis and is thought to promote pulmonary infection by fixing yeast to lung tissue and cells...
- Practice guidelines for the management of patients with blastomycosis. Infectious Diseases Society of AmericaS W Chapman
Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Clin Infect Dis 30:679-83. 2000..Although there are no comparative trials, itraconazole appears more efficacious than either ketoconazole or fluconazole. Thus, itraconazole is the initial treatment of choice for nonlife-threatening non-CNS blastomycosis...
- Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulenceTheerapong Krajaejun
Departments of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
Infect Immun 78:2522-8. 2010b>Blastomyces dermatitidis is a thermally induced dimorphic fungus capable of causing lung and systemic infections in immunocompetent animal hosts. With the publication of genomic sequences from three different strains of B...
- Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulationT Krajaejun
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Univaersity of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Eukaryot Cell 6:1299-309. 2007..gene function would accelerate progress in our understanding of disease pathogenesis for the dimorphic fungus Blastomyces dermatitidis, whose genome is being completed...
- Clinical problem-solving. Building a diagnosis from the ground up--a 49-year-old man came to the clinic with a 1-week history of suprapubic pain and feverBrook Watts
Louis Stokes Cleveland Veterans Affairs Medical Center and the Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
N Engl J Med 356:1456-62. 2007
- Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitationMary E Proctor
Wisconsin Department at Health and Family Servcices, Division of Public Health, Bureau of Communicable Diseases, Madison 53701, USA
Mycopathologia 153:113-20. 2002Much of our understanding of the epidemiologic features of infection with Blastomyces dermatitidis has come from cluster and outbreak investigations which have established the association of human disease with recreational pursuits and ..
- PCR-based detection of DNA from the human pathogen Blastomyces dermatitidis from natural soil samplesJ W Burgess
Department of Microbiology, University of Wisconsin La Crosse, Wisconsin, La Crosse, USA
Med Mycol 44:741-8. 2006b>Blastomyces dermatitidis is the dimorphic fungal agent of blastomycosis, a disease that primarily affects humans and dogs...
- The in vitro isolation of Blastomyces dermatitidis from a woodpile in north central Wisconsin, USAD J Baumgardner
Department of Family Medicine, University of Wisconsin Medical School, St Luke s Family Practice Center, Milwaukee 53215, USA
Med Mycol 37:163-8. 1999Environmental isolations of the dimorphic fungus, Blastomyces dermatitidis, the aetiologic agent of blastomycosis are rare, and have usually involved animal inoculation techniques. We report the in vitro isolation of B...
- BlastomycosisRobert W Bradsher
University of Arkansas for Medical Sciences, Central Arkansas Veterans Administration, Little Rock, AR, USA
Infect Dis Clin North Am 17:21-40, vii. 2003Blastomycosis is an endemic mycoses in the central United States caused by a dimorphic fungus, Blastomyces dermatitidis, that exists in nature in mycelial phase and converts to yeast phase at body temperature...
- CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidisMarcel Wuthrich
University of Wisconsin Hospitals and Clinics, 600 Highland Ave, K4 444, Madison, WI 53792, USA
Infect Immun 73:7436-41. 2005..the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent mechanisms of vaccine immunity to Blastomyces dermatitidis infection...
- Virulence factors of medically important fungiL H Hogan
Department of Pediatrics, University of Wisconsin Medical School, USA
Clin Microbiol Rev 9:469-88. 1996..This growing body of knowledge about fungal pathogens and their virulence factors will significantly aid efforts to treat the serious diseases they cause...
- Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidisL H Hogan
Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
Gene 186:219-26. 1997b>Blastomyces dermatitidis is a primary fungal pathogen of man and other mammals, but like many other human fungal pathogens, relatively little is known about the factors that account for its virulence and pathogenicity...
- Detection of IgG and IgM in sera from canines with blastomycosis using eight blastomyces dermatitidis yeast phase lysate antigensChristine M Sestero
Department of Biological Sciences, Idaho State University, Box 8007, Pocatello, ID 83209, USA
Mycopathologia 162:33-7. 2006The objective of this study was to compare the efficacy of eight Blastomyces dermatitidis yeast phase lysate antigens (T-58: dog, Tennessee; T-27: polar bear, Tennessee; ERC-2: dog, Wisconsin; B5894: human, Minnesota; SOIL: soil, Canada; ..
- In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus speciesG G Zhanel
Department of Medical Microbiology and Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
Antimicrob Agents Chemother 41:863-5. 1997..fluconazole, and ketoconazole against 205 systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species were determined. LY-303366 had MICs of < or = 0...
- Case report: Blastomyces dermatitidis as a cause of middle lobe syndromeJ D Kinzy
Department of Medicine, University of Tennessee Medical Center at Knoxville, USA
Am J Med Sci 312:191-3. 1996..Fungal disease has been implicated rarely as a cause of middle lobe syndrome. This is a patient with Blastomyces dermatitidis infection who presented with right middle lobe syndrome.
- Blastomyces dermatitidis produces melanin in vitro and during infectionJoshua D Nosanchuk
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
FEMS Microbiol Lett 239:187-93. 2004..This study investigates whether the thermally dimorphic fungal pathogen Blastomyces dermatitidis produces melanin...
- Blastomycosis in solid organ transplant recipientsG M Gauthier
Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
Transpl Infect Dis 9:310-7. 2007b>Blastomyces dermatitidis, the etiologic agent of blastomycosis, causes severe disease and substantial mortality in those immunocompromised by acquired immunodeficiency syndrome or malignancy...
- Geographic distribution of human blastomycosis cases in Milwaukee, Wisconsin, USA: association with urban watershedsDennis J Baumgardner
Department of Family Medicine, University of Wisconsin Medical School, Milwaukee Clinical Campus, 2801 W Kinnickinnic River Parkway, Milwaukee, WI 53215, USA
Mycopathologia 161:275-82. 2006..In this urban area of Wisconsin, relatively low incidence rates may be explained, in part, by lower density of inland waterways and lack of sand soils, however, blastomycosis cases appear to be associated with open watersheds...
- Geographic information system analysis of blastomycosis in northern Wisconsin, USA: waterways and soilDennis J Baumgardner
Department of Family Medicine, University of Wisconsin, Milwaukee Clinical Campus, Madison, Wisconsin, USA
Med Mycol 43:117-25. 2005..6 m maximum depth (more lake mixing) (P <0.05, humans and dogs) but mean depth, type and size of lakes did not differ from controls. Further studies are needed to clarify the nature of these associations...
- Urine antigen detection of blastomycosis in pediatric patientsKanokporn Mongkolrattanothai
Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, IL 61637, USA
Pediatr Infect Dis J 25:1076-8. 2006..For the first time, we report the effect of therapy on Blastomyces antigen clearance. In our experience, the urine antigen detection for B...
- A holiday in CanadaEmilie Catherinot
Services de Pneumologie, Hopital Foch, Suresnes, France
Lancet 360:1564. 2002
- Selective expression of the virulence factor BAD1 upon morphogenesis to the pathogenic yeast form of Blastomyces dermatitidis: evidence for transcriptional regulation by a conserved mechanismP J Rooney
Department of Medical Microbiology and Immunology, The Comprehensive Cancer Center, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
Mol Microbiol 39:875-89. 2001..We analysed BAD1 (formerly WI-1), a virulence factor in the dimorphic fungus Blastomyces dermatitidis, for expression in yeast and mycelial morphotypes...
- Coccidioidomycosis and blastomycosis: advances in molecular diagnosisRalf Bialek
Institut fur Tropenmedizin, Universitatsklinikum Tubingen, Germany
FEMS Immunol Med Microbiol 45:355-60. 2005Clinical isolates of Coccidioides spp. and Blastomyces dermatitidis can be identified by chemiluminescent DNA probes and PCR assays targeting multicopy genes...
- Blastomycosis in Ontario, 1994-2003Shaun K Morris
Hospital for Sick Children, Toronto, Ontario, Canada
Emerg Infect Dis 12:274-9. 2006We describe a case of blastomycosis in an 8-year-old boy with Blastomyces-associated osteomyelitis and possible pulmonary involvement...
- Role of glucan and surface protein BAD1 in complement activation by Blastomyces dermatitidis yeastM X Zhang
Department of Microbiology and Cell and Molecular Biology Program, School of Medicine, University of Nevada, Reno, Nevada 89557, USA
Infect Immun 69:7559-64. 2001Our previous studies showed that Blastomyces dermatitidis yeast activates the human complement system, leading to deposition of opsonic complement fragments onto the yeast surface...
- Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidisB S Klein
Department of Pediatrics, University of Wisconsin Medical School, Madison
J Clin Invest 92:330-7. 1993A 120-kD glycoprotein antigen abundantly expressed on Blastomyces dermatitidis yeasts is a target of cellular and humoral immune responses in human infection...
- Small subunit ribosomal DNA sequence shows Paracoccidioides brasiliensis closely related to Blastomyces dermatitidisR Bialek
Institut fur Tropenmedizin, Universitatsklinikum Tubingen, Tubingen, Germany
J Clin Microbiol 38:3190-3. 2000..brasiliensis, Blastomyces dermatitidis, and Emmonsia parva are more closely related than Histoplasma capsulatum and B...
- Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistanceM Wuthrich
Department of Pediatrics, The Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital, Madison, USA
J Clin Invest 106:1381-9. 2000..Pulmonary infection with the dimorphic fungus Blastomyces dermatitidis often progresses and requires treatment to prevent fatality...
- Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactionsB S Klein
Depts of Pediatrics, University of Wisconsin Medical School, Madison, 53792, USA
Trends Microbiol 4:246-51. 1996The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors...
- Foot ulcer and osteomyelitisJohn M Embil
Department of Medicine, University of Manitoba, Winnipeg, Man
CMAJ 174:35-6. 2006
- [Pulmonary infection caused by Blastoschizomices capitatus]A Romano
U O Clinicizzata Malattie Infettive, P O Di Cristina and U O II Rianimazione, P O Civico, ARNAS Civico e Benfratelli, Istituto di Patologia Infettiva e Virologia, Universita degli Studi di Palermo, Italy
Infez Med 13:187-91. 2005..Microbiological diagnosis requires time to characterize the yeast. At present no standard therapy is available although some authors report a good susceptibility to Amphotericin B and Voriconazole (100%), according to NCCLS guidelines...
- Microbiology. Environmentally sensitive protein proves key to making yeast pathogenicElizabeth Pennisi
Science 312:515. 2006
- Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazoleJyoti Panicker
Division of Pediatric Hematology Oncology, Children s National Medical Center, Washington, DC, USA
Pediatr Infect Dis J 25:377-9. 2006Central nervous system involvement in infection with Blastomyces dermatitidis is uncommon, except in immunocompromised patients...
- Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidisMarcel Wuthrich
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Med Mycol 44:41-9. 2006The adhesin BAD1 is required for virulence of Blastomyces dermatitidis in a pulmonary model of infection. Herein, we explored mechanisms by which BAD1 enhances pathogenicity of the fungus...
- Cutaneous blastomycosis: A clue for reassessing the recent diagnosis of pulmonary sarcoidosisIsabelle Auger
Arch Dermatol 142:795-7. 2006
- Beefy red plaque in the popliteal fossaSarah Jane Grekin
University of Iowa Hospitals and Clinics, Iowa City, USA
Arch Dermatol 143:1323-8. 2007
- Disseminated blastomycosis in an infantCatharine M Walsh
Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Pediatr Infect Dis J 25:656-8. 2006Blastomycosis is an uncommon life-threatening disease caused by the dimorphic fungus Blastomyces dermatitidis...
- Blastomycosis presenting as recurrent tender cutaneous nodulesBassel Kisso
Sanford School of Medicine, The University of South Dakota, USA
S D Med 59:255-9. 2006Blastomycosis is caused by inhalation of airborne spores from Blastomyces dermatitidis, a dimorphic fungus found in soil. It is endemic in the southeastern, Midwestern, and south central states of North America...
- Transtracheal aspiration in the diagnosis of pulmonary blastomycosis (17 cases: 2000-2005)Chantal J McMillan
Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan
Can Vet J 49:53-5. 2008b>Blastomyces dermatitidis is a common etiologic agent of fungal pneumonia in dogs. Definitive diagnosis is based on cytologic demonstration of the organism in affected tissues...
- Unilateral Blastomyces dermatitidis optic neuropathy case report and systematic literature reviewBrett Pariseau
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
Ophthalmology 114:2090-4. 2007To describe the clinical and histopathologic findings of a unique case of isolated optic nerve Blastomyces dermatitidis infection and to summarize the ophthalmic blastomycosis literature.
- Antigen and antibody testing for the diagnosis of blastomycosis in dogsD Spector
Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN, USA
J Vet Intern Med 22:839-43. 2008..An enzyme immunoassay (EIA) for detection of Blastomyces dermatitidis galactomannan antigen in body fluids has been used for rapid diagnosis of blastomycosis in humans.
- Blastomyces antigen detection for monitoring progression of blastomycosis in a pregnant adolescentMegan Tarr
Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
Infect Dis Obstet Gynecol 2007:89059. 2007..We investigate the use of the Blastomyces urine antigen in diagnosis following disease progression in the intrapartum, postpartum, and neonatal periods...
- Lingering lesionsParasbhai D Patel
James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Am J Med 121:691-2. 2008
- Isoelectric focusing and ELISA evaluation of a Blastomyces dermatitidis human isolateJack F Shurley
Department of Biological Sciences, Idaho State University, Pocatello, ID 83209, USA
Mycopathologia 164:73-6. 2007b>Blastomyces dermatitidis is a dimorphic fungal organism and the causative agent of blastomycosis. This organism is endemic east of the Mississippi river as is the fungal organism Histoplasma capsulatum...
- Observations on (1-3)-beta-D-glucan detection as a diagnostic tool in endemic mycosis caused by Histoplasma or BlastomycesG Girouard
J Med Microbiol 56:1001-2. 2007
- CNS blastomycosis in a young man working in fields after Hurricane KatrinaViktor Szeder
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neurology 68:1746-7. 2007
- Utility of diagnostic tests for and medical treatment of pulmonary blastomycosis in dogs: 125 cases (1989-2006)Laura J Crews
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
J Am Vet Med Assoc 232:222-7. 2008..To compare results of the most common diagnostic tests for pulmonary blastomycosis in dogs, identify factors associated with outcome, and determine response to various antifungal treatment protocols...
- Massive pleural effusion in a 10-year-oldSergio Fanella
Department of Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, MB, Manitoba, Canada
Pediatr Infect Dis J 27:851-2, 854-5. 2008
- Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infectionChad Schmiedt
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, MI, USA
J Vet Intern Med 20:1351-4. 2006..Blastomycosis is a common systemic fungal infection in dogs...
- Multi-systemic disease in a dogNicole J Fernandez
Calgary Animal Referral and Emergency CARE Centre, 7140 12 Street SE, Calgary, Alberta T2H 2Y4
Can Vet J 49:715-6, 718, 720 passim. 2008
- Blastomycosis in a South Indian patient after visiting an endemic area in USAJayanthi Savio
Department of Microbiology, St John s Medical College and Hospital, Bangalore, India
Med Mycol 44:523-9. 2006..abscess showed many broad-based budding yeast cells and culture yielded a dimorphic fungus later identified as Blastomyces dermatitidis...
- Human and canine pulmonary blastomycosis, North Carolina, 2001-2002Pia D M MacDonald
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 12:1242-4. 2006..Delayed diagnosis, difficulty isolating Blastomyces dermatitidis in nature, and lack of a sensitive and specific test to assess exposure make outbreaks of this ..
- Mixed pulmonary infection with Strongyloides stercoralis and Blastomyces dermatitidisCarmen Sciortino
Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
J Clin Microbiol 44:4270-2. 2006We report the first case of mixed pulmonary infection with Strongyloides stercoralis and Blastomyces dermatitidis. Histopathology from the lung biopsy showed structures consistent with B. dermatitidis and S. stercoralis...
- Narrow-spectrum staining pattern of PityrosporumRanjitha Veerappan
Department of Pathology, East Tennessee State University, Johnson City, TN, USA
J Cutan Pathol 33:731-4. 2006..These stains include mucicarmine and Fontana-Masson (FM) for Cryptococcus, Alcian Blue for Cryptococcus and Blastomyces, Congo Red for Blastomyces and Coccidioides, and Ziehl-Neelsen for some examples of Blastomyces and Histoplasma...
- Evaluation of the use of Congo red staining in the differential diagnosis of Candida vs. various other yeast-form fungal organismsGlen K Axelson
Department of Pathology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0568, USA
J Cutan Pathol 35:27-30. 2008..Histoplasma, Pityrosporum and Blastomyces could provide useful diagnostic information...
- An imported case of Blastomyces dermatitidis infection in MexicoRoberto Velázquez
Instituto Nacional de Enfermedades Respiratorias, Secretaria de Salud, Mexico, D F
Mycopathologia 156:263-7. 2003..S.A. The patient presented pulmonary symptoms prior to development of a skin ulcer. Blastomyces dermatitidis was identified by mycological and molecular procedures...
- Comments on ocular blastomycosis studyGretchen Schmidt
J Am Vet Med Assoc 225:28-9; author reply 29. 2004
- Intramedullary blastomycosis in a child: case reportA M Parr
Division of Neurosurgery, University of Manitoba, Winnipeg, MB, Canada
Can J Neurol Sci 31:282-5. 2004..To report a case of spinal intramedullary blastomycosis causing myelopathy...
- Regulation of vaccine-induced anti-fungal T17 cellsMARCEL WUETHRICH; Fiscal Year: 2013..We have engineered a live attenuated vaccine that protects against infection with the primary fungal pathogen Blastomyces dermatitidis...
- Tracking anti-fungal CD4+ T cells in vivoBRUCE STEVEN KLEIN; Fiscal Year: 2013..We hypothesize that Ag-specific CD4+ T cells that protect against dimorphic fungi - Blastomyces, Histoplasma, and Coccidioides - enter the memory pool and retain the ability long-term to produce IL-17 on re-..
- Molecular Mechanisms that Regulate Phase Transition in Dimorphic FungiGregory M Gauthier; Fiscal Year: 2010..of my research is to uncover and characterize genes that regulate phase transition in dimorphic fungi using Blastomyces dermatitidis as a model...
- MOLECULAR PATHOGENESIS OF BLASTOMYCOSISBRUCE STEVEN KLEIN; Fiscal Year: 2013..immune-competent and -compromised hosts, but the factors responsible for pathogenicity of the causative fungus Blastomyces dermatitidis are not well understood. We identified BAD1 (formerly WI-1), a surface antigen and adhesin on B...
- B DERMATITIDIS CONIDIAL-MACROPHAGE INTERACTIONSStephen Moser; Fiscal Year: 1993..Therefore, a close appraisal of the physiologic role of alveolar macrophages in the primary interaction with Blastomyces dermatitidis conidia is crucial to our understanding of the resulting infectivity of this organism...
- Priming of Antifungal T-Cells at Mucosal and Systemic SitesMARCEL WUETHRICH; Fiscal Year: 2009..Contrary to this paradigm, we find that a live-attenuated, vaccine strain of Blastomyces dermatitidis can protect mice against a lethal pulmonary infection (via Th1 CD4+ T cells) when the attenuated ..
- ENZYME IMMUNOASSAYS FOR THE DIAGNOSIS OF BLASTOMYCOSISGENE SCALARONE; Fiscal Year: 1993Blastomycosis, a systemic granulomatous disease caused by the dimorphic fungal organism Blastomyces dermatitidis, exists in southeastern, southcentral and midwestern areas of the United States...
- MOLECULAR PATHOGENESIS OF PULMONARY HISTOPLASMOSISJON WOODS; Fiscal Year: 2004..Its predicted homology with mammalian EGF-like proteins and a domain of the Blastomyces dermatitis WI-1 antigen is consistent with potential roles in attachment or intracellular signaling...
- Comparative Genomics of Histoplasma and BlastomycesWilliam Goldman; Fiscal Year: 2006..Histoplasma capsulatum and Blastomyces dermatitidis are phylogenetically the most closely related among the dimorphic fungi that cause disease ..
- ANTIFUNGAL ROLE & ACTION OF HUMAN CYTOLYTIC LYMPHOCYTESBruce Klein; Fiscal Year: 1992..The lytic reactions mediated by these cells will be studied in vitro against Blastomyces dermatitidis and related fungi...
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008Infection with the systemic fungi, Histoplasma capsulatum and Blastomyces dermatitidis afflict a large proportion of the population of the United States. H. capsulatum is the leading cause of fungal respiratory disease within the U.S...
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR PATHOGENESIS OF BLASTOMYCOSISBruce Klein; Fiscal Year: 2003DESCRIPTION (Adapted from the applicant's abstract): Blastomyces dermatitidis is a primary and opportunistic dimorphic fungal pathogen, but little is known about its virulence factors. After B...
- MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANSJOSHUA NOSANCHUK; Fiscal Year: 2002..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
- Antibody Protection in HistoplamosisJOSHUA NOSANCHUK; Fiscal Year: 2009..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..