blastomyces

Summary

Summary: A genus of onygenacetous mitosporic fungi whose perfect state is Ajellomyces (see ONYGENALES). The species Blastomyces dermatitidis (perfect state Ajellomyces dermatitidis) causes blastomycosis.

Top Publications

  1. pmc Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D
    Madhavi Lekkala
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Infect Immun 74:4549-56. 2006
  2. pmc Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samples
    Jennifer K Meece
    Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield Clinic, Marshfield, Wisconsin 54449, USA dclin edu
    Med Mycol 48:285-90. 2010
  3. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
  4. pmc Population genetic structure of clinical and environmental isolates of Blastomyces dermatitidis, based on 27 polymorphic microsatellite markers
    Jennifer K Meece
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin 544491, USA
    Appl Environ Microbiol 77:5123-31. 2011
  5. ncbi Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Immunol 173:7444-53. 2004
  6. ncbi Cell wall biogenesis of Blastomyces dermatitidis. Evidence for a novel mechanism of cell surface localization of a virulence-associated adhesin via extracellular release and reassociation with cell wall chitin
    T Brandhorst
    Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and the Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Biol Chem 275:7925-34. 2000
  7. pmc Antigen assay with the potential to aid in diagnosis of blastomycosis
    Michelle Durkin
    MiraVista Diagnostics MiraBella Technologies, Indianapolis, Indiana 46241, USA
    J Clin Microbiol 42:4873-5. 2004
  8. pmc Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis
    T T Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Exp Med 189:1207-16. 1999
  9. pmc Clinical and laboratory update on blastomycosis
    Michael Saccente
    Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 639, Little Rock, AR 72205, USA
    Clin Microbiol Rev 23:367-81. 2010
  10. pmc Ecologic niche modeling of Blastomyces dermatitidis in Wisconsin
    Kurt D Reed
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America
    PLoS ONE 3:e2034. 2008

Research Grants

Detail Information

Publications190 found, 100 shown here

  1. pmc Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D
    Madhavi Lekkala
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Infect Immun 74:4549-56. 2006
    ..effect of surfactant-associated proteins in bronchoalveolar lavage fluid (BALF) on the interaction of BAM and Blastomyces dermatitidis. We investigated BALF enhancement or inhibition of TNF-alpha production by BAM stimulated by B...
  2. pmc Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samples
    Jennifer K Meece
    Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield Clinic, Marshfield, Wisconsin 54449, USA dclin edu
    Med Mycol 48:285-90. 2010
    Blastomycosis is a serious and potentially fatal infection caused by the thermally dimorphic fungus Blastomyces dermatitidis...
  3. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
    ..dispensable for vaccine-induced resistance against experimental fungal pulmonary infections with two agents, Blastomyces dermatitidis an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular pathogen...
  4. pmc Population genetic structure of clinical and environmental isolates of Blastomyces dermatitidis, based on 27 polymorphic microsatellite markers
    Jennifer K Meece
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin 544491, USA
    Appl Environ Microbiol 77:5123-31. 2011
    b>Blastomyces dermatitidis, a thermally dimorphic fungus, is the etiologic agent of North American blastomycosis...
  5. ncbi Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Immunol 173:7444-53. 2004
    ..BAD1, a virulence factor of Blastomyces dermatitidis, is displayed on yeast and released during infection...
  6. ncbi Cell wall biogenesis of Blastomyces dermatitidis. Evidence for a novel mechanism of cell surface localization of a virulence-associated adhesin via extracellular release and reassociation with cell wall chitin
    T Brandhorst
    Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and the Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Biol Chem 275:7925-34. 2000
    Pathogenic yeast of Blastomyces dermatitidis express a surface protein adhesin, WI-1. Due to the crucial role of WI-1 in adherence and disease pathogenesis, we investigated how the protein localizes to the surface of B. dermatitidis...
  7. pmc Antigen assay with the potential to aid in diagnosis of blastomycosis
    Michelle Durkin
    MiraVista Diagnostics MiraBella Technologies, Indianapolis, Indiana 46241, USA
    J Clin Microbiol 42:4873-5. 2004
    We report results of an immunoassay for Blastomyces dermatitidis antigenuria. Sensitivity was 92.9%, and specificity was 79.3%. Cross-reactions occurred in 96...
  8. pmc Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis
    T T Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Exp Med 189:1207-16. 1999
    ..In Blastomyces dermatitidis, the agent of blastomycosis, a respiratory and disseminated mycosis of people and animals ..
  9. pmc Clinical and laboratory update on blastomycosis
    Michael Saccente
    Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 639, Little Rock, AR 72205, USA
    Clin Microbiol Rev 23:367-81. 2010
    ..and children because men are more likely to participate in activities that put them at risk for exposure to Blastomyces dermatitidis...
  10. pmc Ecologic niche modeling of Blastomyces dermatitidis in Wisconsin
    Kurt D Reed
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America
    PLoS ONE 3:e2034. 2008
    Blastomycosis is a potentially fatal mycosis that is acquired by inhaling infectious spores of Blastomyces dermatitidis present in the environment...
  11. pmc Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages
    B S Klein
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison 53792
    Infect Immun 62:3536-42. 1994
    The molecular basis for pathogenicity and virulence of the dimorphic fungus Blastomyces dermatitidis remains unknown. WI-1 is a major cell wall protein of B...
  12. ncbi Studies on the molecular ecology of Blastomyces dermatitidis
    D J Baumgardner
    Department of Family Medicine, University of Wisconsin Medical School, Milwaukee 53215, USA
    Mycopathologia 152:51-8. 2001
    The microecology of Blastomyces dermatitidis, the dimorphic etiologic agent of the potentially fatal systemic fungal infection, blastomycosis, is not well defined...
  13. ncbi Skeletal muscle abscess caused by Blastomyces dermatitidis
    Constantine Tsigrelis
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Med Sci 337:293-4. 2009
    ..We, therefore, report a case of a large gluteal muscle abscess caused by Blastomyces dermatitidis in a young, immunocompetent male...
  14. ncbi Seasonal variations in the clinical presentation of pulmonary and extrapulmonary blastomycosis
    R Bruce Light
    Section of Infectious Diseases, Department of Medicine, University of Manitoba, Winnipeg
    Med Mycol 46:835-41. 2008
    Blastomycosis is a granulomatous infection caused by the thermally dimorphic fungus, Blastomyces dermatitidis, for which seasonal variation has been proposed...
  15. ncbi Blastomycosis in indiana: digging up more cases
    W Graham Carlos
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, Indianapolis, IN 46202, USA
    Chest 138:1377-82. 2010
    ..We propose that this surge was related to major highway construction around Indianapolis...
  16. ncbi A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis
    Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
    Mol Microbiol 48:53-65. 2003
    BAD1, an adhesin and immune modulator of Blastomyces dermatitidis, is an essential virulence factor that is released extracellularly before association with the yeast surface...
  17. ncbi Purification in quantity of the secreted form of WI-1: a major adhesin on Blastomyces dermatitidis yeasts
    R Audet
    Comprehensive Cancer Center, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Protein Expr Purif 11:219-26. 1997
    WI-1, a 120-kDa adhesin on Blastomyces dermatitidis, binds the yeast to macrophages and is a major target antigen of immune recognition in acquired resistance to the fungus...
  18. pmc African strains of Blastomyces dermatitidis that do not express surface adhesin WI-1
    B S Klein
    Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
    Infect Immun 65:1505-9. 1997
    African strains of Blastomyces dermatitidis differ from North American strains in their growth, morphology, and clinical disease phenotype. In addition, two serotypes, designated 1 and 2, have been described...
  19. ncbi Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University Hospital and Clinics, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    J Immunol 176:5538-47. 2006
    ..We explored the role of CD40/CD40L interactions in vaccine immunity to Blastomyces dermatitidis by immunizing CD40(-/-) and CD40L(-/-) mice and analyzing their resistance to reinfection in a ..
  20. ncbi Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeasts
    L H Hogan
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madision 53792, USA
    J Biol Chem 270:30725-32. 1995
    WI-1 is a 120-kDa surface protein adhesin on Blastomyces dermatitidis yeasts that binds CD18 and CD14 receptors on human macrophages...
  21. ncbi The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14
    S L Newman
    Department of Medicine, University of Cincinnati College of Medicine, OH 45267
    J Immunol 154:753-61. 1995
    Three genetically related strains of Blastomyces dermatitidis (Bd) yeasts that differ in their expression of WI-1, an immunodominant cell wall Ag, were tested for their capacity to bind to human macrophages (M phi) in the absence of ..
  22. pmc Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis
    Wenjun Li
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA
    Eukaryot Cell 12:109-17. 2013
    b>Blastomyces dermatitidis is a dimorphic fungal pathogen that primarily causes blastomycosis in the midwestern and northern United States and Canada...
  23. ncbi Blastomycosis: Case report of an isolated lesion in the distal fibula
    A Alex Jahangir
    Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Orthop (Belle Mead NJ) 39:E22-4. 2010
    Blastomycosis (Blastomyces dermatitidis) is a fungal infection that occurs primarily in the lungs, but 15% to 60% of patients with systemic blastomycosis have skeletal involvement...
  24. ncbi Global control of dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Science 312:583-8. 2006
    ..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease...
  25. pmc Non-rural point source blastomycosis outbreak near a yard waste collection site
    John R Pfister
    Bureau of Communicable Disease and Emergency Response, Wisconsin Division of Public Health, Madison, Wisconsin 53701, USA
    Clin Med Res 9:57-65. 2011
    Blastomycosis is a potentially fatal infection caused by the fungus Blastomyces dermatitidis...
  26. ncbi Molecular genetic analysis of Blastomyces dermatitidis reveals new insights about pathogenic mechanisms
    T Tristan Brandhorst
    Departments of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Int J Med Microbiol 292:363-71. 2002
    ..Advances in the molecular tools for genetic manipulation of Blastomyces dermatitidis have enhanced our ability to study this poorly understood dimorphic fungal pathogen...
  27. pmc Purification and characterization of the major antigen WI-1 from Blastomyces dermatitidis yeasts and immunological comparison with A antigen
    B S Klein
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison
    Infect Immun 62:3890-900. 1994
    The lack of well-defined antigens from Blastomyces dermatitidis has hampered the ability to reliably diagnose human infection and study the immunobiology of blastomycosis. We recently discovered a novel surface protein on B...
  28. ncbi Effects of season and weather on blastomycosis in dogs: Northern Wisconsin, USA
    Dennis J Baumgardner
    Department of Family Medicine, Aurora UW Medical Group, University of Wisconsin School of Medicine and Public Health, Center for Urban Population Health, Milwaukee, USA
    Med Mycol 49:49-55. 2011
    Dogs and humans acquire Blastomyces dermatitidis infections from the same incompletely defined habitat. Studies of blastomycosis cases have not consistently demonstrated seasonality or significant antecedent climate effects...
  29. ncbi Clinical aspects of natural infection with Blastomyces dermatitidis in cats: 8 cases (1991-2005)
    Chen Gilor
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    J Am Vet Med Assoc 229:96-9. 2006
    ..To evaluate clinical and laboratory findings, treatment, and clinical outcome in cats with blastomycosis...
  30. ncbi Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis)
    L Sigler
    University of Alberta Microfungus Collection and Herbarium, Edmonton, Canada
    J Med Vet Mycol 34:303-14. 1996
    ..Phenotypic similarities between Emmonsia spp. and Blastomyces dermatitidis and chance observation of Ajellomyces-type ascomatal hyphae led to the hypothesis that the ..
  31. ncbi Variation in clinical phenotype of human infection among genetic groups of Blastomyces dermatitidis
    Jennifer K Meece
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
    J Infect Dis 207:814-22. 2013
    b>Blastomyces dermatitidis, the etiologic agent of blastomycosis, has 2 genetic groups and shows varied clinical presentation, ranging from silent infections to fulminant respiratory disease and dissemination...
  32. ncbi Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Biol Chem 280:42156-63. 2005
    BAD-1 (Blastomyces adhesin 1), a 120-kDa protein of Blastomyces dermatitidis, functions as an adhesin, immune modulator, and essential virulence factor...
  33. ncbi Defining virulence genes in the dimorphic fungi
    Chad A Rappleye
    Department of Microbiology, Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Microbiol 60:281-303. 2006
    ..Thus, the stage is set and the tools are in place for the next phase of medical mycology research: defining the virulence-associated factors underlying the success of dimorphic fungal pathogens...
  34. ncbi Cutaneous inoculation blastomycosis
    Nathan A Gray
    Section of Infectious Diseases, Department of Medicine, Graduate School of Medicine, University of Tennessee Medical Center at Knoxville, Knoxville, TN 37920, USA
    Clin Infect Dis 34:E44-9. 2002
    ..We also review cases of cutaneous inoculation blastomycosis described elsewhere, to improve characterization of the syndrome...
  35. ncbi BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms
    Beatriz Finkel-Jimenez
    Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792
    J Immunol 168:5746-55. 2002
    We investigated how BAD1, an adhesin and virulence factor of Blastomyces dermatitidis, suppresses phagocyte proinflammatory responses...
  36. ncbi Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 169:6969-76. 2002
    ..Vaccination with a genetically engineered, live, attenuated strain of Blastomyces dermatitidis carrying a targeted deletion at the BAD1 locus confers sterilizing immunity against experimental ..
  37. pmc V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Infect Immun 75:193-200. 2007
    Immunization with a cell wall/membrane (CW/M) and yeast cytosol extract (YCE) crude antigen from Blastomyces dermatitidis confers T-cell-mediated resistance against lethal experimental infection in mice...
  38. pmc Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis
    M Wuthrich
    Departments of Pediatrics, Internal Medicine, Medical Microbiology and Immunology, Comprehensive Cancer Center, University of Wisconsin Medical School, Hospitals and Clinics, Madison, WI 53792, USA
    Infect Immun 66:5443-9. 1998
    People infected with Blastomyces dermatitidis develop strong immunity to the yeast surface adhesin WI-1, including antibody responses to the adhesive domain, a 25-amino-acid repeat, and cellular responses to the N terminus...
  39. ncbi Pulmonary blastomycosis: a great masquerader
    Jeanne Wallace
    Chest 121:677-9. 2002
  40. pmc Nested PCR assays for detection of Blastomyces dermatitidis DNA in paraffin-embedded canine tissue
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Tubingen, Germany
    J Clin Microbiol 41:205-8. 2003
    A Blastomyces dermatitidis nested PCR assay targeting the gene encoding the Wisconsin 1 (WI-1) adhesin was developed and compared with a nested PCR targeting the 18S rRNA gene (rDNA) of members of the family ONYGENACEAE: We examined 73 ..
  41. pmc Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 72:3478-88. 2004
    ..Yeast forms of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum were each ingested by amoebae and macrophages, ..
  42. pmc Sequence elements necessary for transcriptional activation of BAD1 in the yeast phase of Blastomyces dermatitidis
    Peggy J Rooney
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Eukaryot Cell 3:785-94. 2004
    b>Blastomyces dermatitidis is a dimorphic fungal pathogen that converts from mycelia or conidia to a host-adapted yeast morphotype upon infection. Conversion to the yeast form is accompanied by the production of the virulence factor BAD1...
  43. pmc Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis
    Adi Koneti
    California Institute for Medical Research and Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128 2699, USA
    Infect Immun 76:994-1002. 2008
    ..Little is known about the effects of serum factors or MBL on the interaction of Blastomyces dermatitidis, a pulmonary fungal pathogen, with macrophages or on tumor necrosis factor alpha (TNF-alpha) ..
  44. ncbi The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidis
    B Finkel Jimenez
    Department of Pediatrics, Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, USA
    J Immunol 166:2665-73. 2001
    The WI-1 adhesin is indispensable for pathogenicity of Blastomyces dermatitidis and is thought to promote pulmonary infection by fixing yeast to lung tissue and cells...
  45. ncbi Practice guidelines for the management of patients with blastomycosis. Infectious Diseases Society of America
    S W Chapman
    Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Clin Infect Dis 30:679-83. 2000
    ..Although there are no comparative trials, itraconazole appears more efficacious than either ketoconazole or fluconazole. Thus, itraconazole is the initial treatment of choice for nonlife-threatening non-CNS blastomycosis...
  46. pmc Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence
    Theerapong Krajaejun
    Departments of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Infect Immun 78:2522-8. 2010
    b>Blastomyces dermatitidis is a thermally induced dimorphic fungus capable of causing lung and systemic infections in immunocompetent animal hosts. With the publication of genomic sequences from three different strains of B...
  47. pmc Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulation
    T Krajaejun
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Univaersity of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Eukaryot Cell 6:1299-309. 2007
    ..gene function would accelerate progress in our understanding of disease pathogenesis for the dimorphic fungus Blastomyces dermatitidis, whose genome is being completed...
  48. ncbi Clinical problem-solving. Building a diagnosis from the ground up--a 49-year-old man came to the clinic with a 1-week history of suprapubic pain and fever
    Brook Watts
    Louis Stokes Cleveland Veterans Affairs Medical Center and the Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    N Engl J Med 356:1456-62. 2007
  49. ncbi Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation
    Mary E Proctor
    Wisconsin Department at Health and Family Servcices, Division of Public Health, Bureau of Communicable Diseases, Madison 53701, USA
    Mycopathologia 153:113-20. 2002
    Much of our understanding of the epidemiologic features of infection with Blastomyces dermatitidis has come from cluster and outbreak investigations which have established the association of human disease with recreational pursuits and ..
  50. ncbi PCR-based detection of DNA from the human pathogen Blastomyces dermatitidis from natural soil samples
    J W Burgess
    Department of Microbiology, University of Wisconsin La Crosse, Wisconsin, La Crosse, USA
    Med Mycol 44:741-8. 2006
    b>Blastomyces dermatitidis is the dimorphic fungal agent of blastomycosis, a disease that primarily affects humans and dogs...
  51. ncbi The in vitro isolation of Blastomyces dermatitidis from a woodpile in north central Wisconsin, USA
    D J Baumgardner
    Department of Family Medicine, University of Wisconsin Medical School, St Luke s Family Practice Center, Milwaukee 53215, USA
    Med Mycol 37:163-8. 1999
    Environmental isolations of the dimorphic fungus, Blastomyces dermatitidis, the aetiologic agent of blastomycosis are rare, and have usually involved animal inoculation techniques. We report the in vitro isolation of B...
  52. ncbi Blastomycosis
    Robert W Bradsher
    University of Arkansas for Medical Sciences, Central Arkansas Veterans Administration, Little Rock, AR, USA
    Infect Dis Clin North Am 17:21-40, vii. 2003
    Blastomycosis is an endemic mycoses in the central United States caused by a dimorphic fungus, Blastomyces dermatitidis, that exists in nature in mycelial phase and converts to yeast phase at body temperature...
  53. pmc CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    University of Wisconsin Hospitals and Clinics, 600 Highland Ave, K4 444, Madison, WI 53792, USA
    Infect Immun 73:7436-41. 2005
    ..the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent mechanisms of vaccine immunity to Blastomyces dermatitidis infection...
  54. pmc Virulence factors of medically important fungi
    L H Hogan
    Department of Pediatrics, University of Wisconsin Medical School, USA
    Clin Microbiol Rev 9:469-88. 1996
    ..This growing body of knowledge about fungal pathogens and their virulence factors will significantly aid efforts to treat the serious diseases they cause...
  55. ncbi Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis
    L H Hogan
    Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
    Gene 186:219-26. 1997
    b>Blastomyces dermatitidis is a primary fungal pathogen of man and other mammals, but like many other human fungal pathogens, relatively little is known about the factors that account for its virulence and pathogenicity...
  56. ncbi Detection of IgG and IgM in sera from canines with blastomycosis using eight blastomyces dermatitidis yeast phase lysate antigens
    Christine M Sestero
    Department of Biological Sciences, Idaho State University, Box 8007, Pocatello, ID 83209, USA
    Mycopathologia 162:33-7. 2006
    The objective of this study was to compare the efficacy of eight Blastomyces dermatitidis yeast phase lysate antigens (T-58: dog, Tennessee; T-27: polar bear, Tennessee; ERC-2: dog, Wisconsin; B5894: human, Minnesota; SOIL: soil, Canada; ..
  57. pmc In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species
    G G Zhanel
    Department of Medical Microbiology and Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    Antimicrob Agents Chemother 41:863-5. 1997
    ..fluconazole, and ketoconazole against 205 systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species were determined. LY-303366 had MICs of < or = 0...
  58. ncbi Case report: Blastomyces dermatitidis as a cause of middle lobe syndrome
    J D Kinzy
    Department of Medicine, University of Tennessee Medical Center at Knoxville, USA
    Am J Med Sci 312:191-3. 1996
    ..Fungal disease has been implicated rarely as a cause of middle lobe syndrome. This is a patient with Blastomyces dermatitidis infection who presented with right middle lobe syndrome.
  59. ncbi Blastomyces dermatitidis produces melanin in vitro and during infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    FEMS Microbiol Lett 239:187-93. 2004
    ..This study investigates whether the thermally dimorphic fungal pathogen Blastomyces dermatitidis produces melanin...
  60. ncbi Blastomycosis in solid organ transplant recipients
    G M Gauthier
    Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
    Transpl Infect Dis 9:310-7. 2007
    b>Blastomyces dermatitidis, the etiologic agent of blastomycosis, causes severe disease and substantial mortality in those immunocompromised by acquired immunodeficiency syndrome or malignancy...
  61. ncbi Geographic distribution of human blastomycosis cases in Milwaukee, Wisconsin, USA: association with urban watersheds
    Dennis J Baumgardner
    Department of Family Medicine, University of Wisconsin Medical School, Milwaukee Clinical Campus, 2801 W Kinnickinnic River Parkway, Milwaukee, WI 53215, USA
    Mycopathologia 161:275-82. 2006
    ..In this urban area of Wisconsin, relatively low incidence rates may be explained, in part, by lower density of inland waterways and lack of sand soils, however, blastomycosis cases appear to be associated with open watersheds...
  62. ncbi Geographic information system analysis of blastomycosis in northern Wisconsin, USA: waterways and soil
    Dennis J Baumgardner
    Department of Family Medicine, University of Wisconsin, Milwaukee Clinical Campus, Madison, Wisconsin, USA
    Med Mycol 43:117-25. 2005
    ..6 m maximum depth (more lake mixing) (P <0.05, humans and dogs) but mean depth, type and size of lakes did not differ from controls. Further studies are needed to clarify the nature of these associations...
  63. ncbi Urine antigen detection of blastomycosis in pediatric patients
    Kanokporn Mongkolrattanothai
    Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, IL 61637, USA
    Pediatr Infect Dis J 25:1076-8. 2006
    ..For the first time, we report the effect of therapy on Blastomyces antigen clearance. In our experience, the urine antigen detection for B...
  64. ncbi A holiday in Canada
    Emilie Catherinot
    Services de Pneumologie, Hopital Foch, Suresnes, France
    Lancet 360:1564. 2002
  65. ncbi Selective expression of the virulence factor BAD1 upon morphogenesis to the pathogenic yeast form of Blastomyces dermatitidis: evidence for transcriptional regulation by a conserved mechanism
    P J Rooney
    Department of Medical Microbiology and Immunology, The Comprehensive Cancer Center, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
    Mol Microbiol 39:875-89. 2001
    ..We analysed BAD1 (formerly WI-1), a virulence factor in the dimorphic fungus Blastomyces dermatitidis, for expression in yeast and mycelial morphotypes...
  66. ncbi Coccidioidomycosis and blastomycosis: advances in molecular diagnosis
    Ralf Bialek
    Institut fur Tropenmedizin, Universitatsklinikum Tubingen, Germany
    FEMS Immunol Med Microbiol 45:355-60. 2005
    Clinical isolates of Coccidioides spp. and Blastomyces dermatitidis can be identified by chemiluminescent DNA probes and PCR assays targeting multicopy genes...
  67. pmc Blastomycosis in Ontario, 1994-2003
    Shaun K Morris
    Hospital for Sick Children, Toronto, Ontario, Canada
    Emerg Infect Dis 12:274-9. 2006
    We describe a case of blastomycosis in an 8-year-old boy with Blastomyces-associated osteomyelitis and possible pulmonary involvement...
  68. pmc Role of glucan and surface protein BAD1 in complement activation by Blastomyces dermatitidis yeast
    M X Zhang
    Department of Microbiology and Cell and Molecular Biology Program, School of Medicine, University of Nevada, Reno, Nevada 89557, USA
    Infect Immun 69:7559-64. 2001
    Our previous studies showed that Blastomyces dermatitidis yeast activates the human complement system, leading to deposition of opsonic complement fragments onto the yeast surface...
  69. pmc Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis
    B S Klein
    Department of Pediatrics, University of Wisconsin Medical School, Madison
    J Clin Invest 92:330-7. 1993
    A 120-kD glycoprotein antigen abundantly expressed on Blastomyces dermatitidis yeasts is a target of cellular and humoral immune responses in human infection...
  70. pmc Small subunit ribosomal DNA sequence shows Paracoccidioides brasiliensis closely related to Blastomyces dermatitidis
    R Bialek
    Institut fur Tropenmedizin, Universitatsklinikum Tubingen, Tubingen, Germany
    J Clin Microbiol 38:3190-3. 2000
    ..brasiliensis, Blastomyces dermatitidis, and Emmonsia parva are more closely related than Histoplasma capsulatum and B...
  71. pmc Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance
    M Wuthrich
    Department of Pediatrics, The Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital, Madison, USA
    J Clin Invest 106:1381-9. 2000
    ..Pulmonary infection with the dimorphic fungus Blastomyces dermatitidis often progresses and requires treatment to prevent fatality...
  72. ncbi Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions
    B S Klein
    Depts of Pediatrics, University of Wisconsin Medical School, Madison, 53792, USA
    Trends Microbiol 4:246-51. 1996
    The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors...
  73. pmc Foot ulcer and osteomyelitis
    John M Embil
    Department of Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 174:35-6. 2006
  74. ncbi [Pulmonary infection caused by Blastoschizomices capitatus]
    A Romano
    U O Clinicizzata Malattie Infettive, P O Di Cristina and U O II Rianimazione, P O Civico, ARNAS Civico e Benfratelli, Istituto di Patologia Infettiva e Virologia, Universita degli Studi di Palermo, Italy
    Infez Med 13:187-91. 2005
    ..Microbiological diagnosis requires time to characterize the yeast. At present no standard therapy is available although some authors report a good susceptibility to Amphotericin B and Voriconazole (100%), according to NCCLS guidelines...
  75. ncbi Microbiology. Environmentally sensitive protein proves key to making yeast pathogenic
    Elizabeth Pennisi
    Science 312:515. 2006
  76. ncbi Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole
    Jyoti Panicker
    Division of Pediatric Hematology Oncology, Children s National Medical Center, Washington, DC, USA
    Pediatr Infect Dis J 25:377-9. 2006
    Central nervous system involvement in infection with Blastomyces dermatitidis is uncommon, except in immunocompromised patients...
  77. ncbi Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Med Mycol 44:41-9. 2006
    The adhesin BAD1 is required for virulence of Blastomyces dermatitidis in a pulmonary model of infection. Herein, we explored mechanisms by which BAD1 enhances pathogenicity of the fungus...
  78. ncbi Cutaneous blastomycosis: A clue for reassessing the recent diagnosis of pulmonary sarcoidosis
    Isabelle Auger
    Arch Dermatol 142:795-7. 2006
  79. ncbi Beefy red plaque in the popliteal fossa
    Sarah Jane Grekin
    University of Iowa Hospitals and Clinics, Iowa City, USA
    Arch Dermatol 143:1323-8. 2007
  80. ncbi Disseminated blastomycosis in an infant
    Catharine M Walsh
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Infect Dis J 25:656-8. 2006
    Blastomycosis is an uncommon life-threatening disease caused by the dimorphic fungus Blastomyces dermatitidis...
  81. ncbi Blastomycosis presenting as recurrent tender cutaneous nodules
    Bassel Kisso
    Sanford School of Medicine, The University of South Dakota, USA
    S D Med 59:255-9. 2006
    Blastomycosis is caused by inhalation of airborne spores from Blastomyces dermatitidis, a dimorphic fungus found in soil. It is endemic in the southeastern, Midwestern, and south central states of North America...
  82. pmc Transtracheal aspiration in the diagnosis of pulmonary blastomycosis (17 cases: 2000-2005)
    Chantal J McMillan
    Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan
    Can Vet J 49:53-5. 2008
    b>Blastomyces dermatitidis is a common etiologic agent of fungal pneumonia in dogs. Definitive diagnosis is based on cytologic demonstration of the organism in affected tissues...
  83. ncbi Unilateral Blastomyces dermatitidis optic neuropathy case report and systematic literature review
    Brett Pariseau
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 114:2090-4. 2007
    To describe the clinical and histopathologic findings of a unique case of isolated optic nerve Blastomyces dermatitidis infection and to summarize the ophthalmic blastomycosis literature.
  84. ncbi Antigen and antibody testing for the diagnosis of blastomycosis in dogs
    D Spector
    Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN, USA
    J Vet Intern Med 22:839-43. 2008
    ..An enzyme immunoassay (EIA) for detection of Blastomyces dermatitidis galactomannan antigen in body fluids has been used for rapid diagnosis of blastomycosis in humans.
  85. pmc Blastomyces antigen detection for monitoring progression of blastomycosis in a pregnant adolescent
    Megan Tarr
    Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
    Infect Dis Obstet Gynecol 2007:89059. 2007
    ..We investigate the use of the Blastomyces urine antigen in diagnosis following disease progression in the intrapartum, postpartum, and neonatal periods...
  86. doi Lingering lesions
    Parasbhai D Patel
    James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Med 121:691-2. 2008
  87. ncbi Isoelectric focusing and ELISA evaluation of a Blastomyces dermatitidis human isolate
    Jack F Shurley
    Department of Biological Sciences, Idaho State University, Pocatello, ID 83209, USA
    Mycopathologia 164:73-6. 2007
    b>Blastomyces dermatitidis is a dimorphic fungal organism and the causative agent of blastomycosis. This organism is endemic east of the Mississippi river as is the fungal organism Histoplasma capsulatum...
  88. ncbi Observations on (1-3)-beta-D-glucan detection as a diagnostic tool in endemic mycosis caused by Histoplasma or Blastomyces
    G Girouard
    J Med Microbiol 56:1001-2. 2007
  89. ncbi CNS blastomycosis in a young man working in fields after Hurricane Katrina
    Viktor Szeder
    Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neurology 68:1746-7. 2007
  90. ncbi Utility of diagnostic tests for and medical treatment of pulmonary blastomycosis in dogs: 125 cases (1989-2006)
    Laura J Crews
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    J Am Vet Med Assoc 232:222-7. 2008
    ..To compare results of the most common diagnostic tests for pulmonary blastomycosis in dogs, identify factors associated with outcome, and determine response to various antifungal treatment protocols...
  91. doi Massive pleural effusion in a 10-year-old
    Sergio Fanella
    Department of Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, MB, Manitoba, Canada
    Pediatr Infect Dis J 27:851-2, 854-5. 2008
  92. ncbi Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infection
    Chad Schmiedt
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, MI, USA
    J Vet Intern Med 20:1351-4. 2006
    ..Blastomycosis is a common systemic fungal infection in dogs...
  93. pmc Multi-systemic disease in a dog
    Nicole J Fernandez
    Calgary Animal Referral and Emergency CARE Centre, 7140 12 Street SE, Calgary, Alberta T2H 2Y4
    Can Vet J 49:715-6, 718, 720 passim. 2008
  94. ncbi Blastomycosis in a South Indian patient after visiting an endemic area in USA
    Jayanthi Savio
    Department of Microbiology, St John s Medical College and Hospital, Bangalore, India
    Med Mycol 44:523-9. 2006
    ..abscess showed many broad-based budding yeast cells and culture yielded a dimorphic fungus later identified as Blastomyces dermatitidis...
  95. pmc Human and canine pulmonary blastomycosis, North Carolina, 2001-2002
    Pia D M MacDonald
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 12:1242-4. 2006
    ..Delayed diagnosis, difficulty isolating Blastomyces dermatitidis in nature, and lack of a sensitive and specific test to assess exposure make outbreaks of this ..
  96. pmc Mixed pulmonary infection with Strongyloides stercoralis and Blastomyces dermatitidis
    Carmen Sciortino
    Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Clin Microbiol 44:4270-2. 2006
    We report the first case of mixed pulmonary infection with Strongyloides stercoralis and Blastomyces dermatitidis. Histopathology from the lung biopsy showed structures consistent with B. dermatitidis and S. stercoralis...
  97. ncbi Narrow-spectrum staining pattern of Pityrosporum
    Ranjitha Veerappan
    Department of Pathology, East Tennessee State University, Johnson City, TN, USA
    J Cutan Pathol 33:731-4. 2006
    ..These stains include mucicarmine and Fontana-Masson (FM) for Cryptococcus, Alcian Blue for Cryptococcus and Blastomyces, Congo Red for Blastomyces and Coccidioides, and Ziehl-Neelsen for some examples of Blastomyces and Histoplasma...
  98. ncbi Evaluation of the use of Congo red staining in the differential diagnosis of Candida vs. various other yeast-form fungal organisms
    Glen K Axelson
    Department of Pathology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0568, USA
    J Cutan Pathol 35:27-30. 2008
    ..Histoplasma, Pityrosporum and Blastomyces could provide useful diagnostic information...
  99. ncbi An imported case of Blastomyces dermatitidis infection in Mexico
    Roberto Velázquez
    Instituto Nacional de Enfermedades Respiratorias, Secretaria de Salud, Mexico, D F
    Mycopathologia 156:263-7. 2003
    ..S.A. The patient presented pulmonary symptoms prior to development of a skin ulcer. Blastomyces dermatitidis was identified by mycological and molecular procedures...
  100. ncbi Comments on ocular blastomycosis study
    Gretchen Schmidt
    J Am Vet Med Assoc 225:28-9; author reply 29. 2004
  101. ncbi Intramedullary blastomycosis in a child: case report
    A M Parr
    Division of Neurosurgery, University of Manitoba, Winnipeg, MB, Canada
    Can J Neurol Sci 31:282-5. 2004
    ..To report a case of spinal intramedullary blastomycosis causing myelopathy...

Research Grants16

  1. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..We have engineered a live attenuated vaccine that protects against infection with the primary fungal pathogen Blastomyces dermatitidis...
  2. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..We hypothesize that Ag-specific CD4+ T cells that protect against dimorphic fungi - Blastomyces, Histoplasma, and Coccidioides - enter the memory pool and retain the ability long-term to produce IL-17 on re-..
  3. Molecular Mechanisms that Regulate Phase Transition in Dimorphic Fungi
    Gregory M Gauthier; Fiscal Year: 2010
    ..of my research is to uncover and characterize genes that regulate phase transition in dimorphic fungi using Blastomyces dermatitidis as a model...
  4. MOLECULAR PATHOGENESIS OF BLASTOMYCOSIS
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..immune-competent and -compromised hosts, but the factors responsible for pathogenicity of the causative fungus Blastomyces dermatitidis are not well understood. We identified BAD1 (formerly WI-1), a surface antigen and adhesin on B...
  5. B DERMATITIDIS CONIDIAL-MACROPHAGE INTERACTIONS
    Stephen Moser; Fiscal Year: 1993
    ..Therefore, a close appraisal of the physiologic role of alveolar macrophages in the primary interaction with Blastomyces dermatitidis conidia is crucial to our understanding of the resulting infectivity of this organism...
  6. Priming of Antifungal T-Cells at Mucosal and Systemic Sites
    MARCEL WUETHRICH; Fiscal Year: 2009
    ..Contrary to this paradigm, we find that a live-attenuated, vaccine strain of Blastomyces dermatitidis can protect mice against a lethal pulmonary infection (via Th1 CD4+ T cells) when the attenuated ..
  7. ENZYME IMMUNOASSAYS FOR THE DIAGNOSIS OF BLASTOMYCOSIS
    GENE SCALARONE; Fiscal Year: 1993
    Blastomycosis, a systemic granulomatous disease caused by the dimorphic fungal organism Blastomyces dermatitidis, exists in southeastern, southcentral and midwestern areas of the United States...
  8. MOLECULAR PATHOGENESIS OF PULMONARY HISTOPLASMOSIS
    JON WOODS; Fiscal Year: 2004
    ..Its predicted homology with mammalian EGF-like proteins and a domain of the Blastomyces dermatitis WI-1 antigen is consistent with potential roles in attachment or intracellular signaling...
  9. Comparative Genomics of Histoplasma and Blastomyces
    William Goldman; Fiscal Year: 2006
    ..Histoplasma capsulatum and Blastomyces dermatitidis are phylogenetically the most closely related among the dimorphic fungi that cause disease ..
  10. ANTIFUNGAL ROLE & ACTION OF HUMAN CYTOLYTIC LYMPHOCYTES
    Bruce Klein; Fiscal Year: 1992
    ..The lytic reactions mediated by these cells will be studied in vitro against Blastomyces dermatitidis and related fungi...
  11. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    Infection with the systemic fungi, Histoplasma capsulatum and Blastomyces dermatitidis afflict a large proportion of the population of the United States. H. capsulatum is the leading cause of fungal respiratory disease within the U.S...
  12. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  13. MOLECULAR PATHOGENESIS OF BLASTOMYCOSIS
    Bruce Klein; Fiscal Year: 2003
    DESCRIPTION (Adapted from the applicant's abstract): Blastomyces dermatitidis is a primary and opportunistic dimorphic fungal pathogen, but little is known about its virulence factors. After B...
  14. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  15. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..