aspergillus fumigatus

Summary

Summary: A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.

Top Publications

  1. pmc Aspergillus fumigatus and aspergillosis
    J P Latge
    Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France
    Clin Microbiol Rev 12:310-50. 1999
  2. pmc A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus
    Sven D Willger
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, USA
    PLoS Pathog 4:e1000200. 2008
  3. pmc Sub-telomere directed gene expression during initiation of invasive aspergillosis
    Andrew McDonagh
    Department of Microbiology, Imperial College London, London, United Kingdom
    PLoS Pathog 4:e1000154. 2008
  4. ncbi Surface hydrophobin prevents immune recognition of airborne fungal spores
    Vishukumar Aimanianda
    Unite des Aspergillus, Institut Pasteur, Paris F 75015, France
    Nature 460:1117-21. 2009
  5. pmc Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
    Taylor R T Dagenais
    Medical Microbiology and Immunology, University of Wisconsin Madison, 3467 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA
    Clin Microbiol Rev 22:447-65. 2009
  6. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
  7. pmc Global transcriptome changes underlying colony growth in the opportunistic human pathogen Aspergillus fumigatus
    John G Gibbons
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Eukaryot Cell 11:68-78. 2012
  8. pmc The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
    Radhika Jain
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Mol Microbiol 82:39-53. 2011
  9. pmc Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia
    Martin Vödisch
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute and Friedrich Schiller University, Jena, Germany
    J Proteome Res 10:2508-24. 2011
  10. ncbi Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus
    Céline M O'Gorman
    UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 457:471-4. 2009

Detail Information

Publications263 found, 100 shown here

  1. pmc Aspergillus fumigatus and aspergillosis
    J P Latge
    Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France
    Clin Microbiol Rev 12:310-50. 1999
    b>Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhale numerous conidia of this fungus...
  2. pmc A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus
    Sven D Willger
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, USA
    PLoS Pathog 4:e1000200. 2008
    ..of a sterol-regulatory element binding protein, SrbA, in the opportunistic pathogenic mold, Aspergillus fumigatus. Loss of SrbA results in a mutant strain of the fungus that is incapable of growth in a hypoxic ..
  3. pmc Sub-telomere directed gene expression during initiation of invasive aspergillosis
    Andrew McDonagh
    Department of Microbiology, Imperial College London, London, United Kingdom
    PLoS Pathog 4:e1000154. 2008
    b>Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora...
  4. ncbi Surface hydrophobin prevents immune recognition of airborne fungal spores
    Vishukumar Aimanianda
    Unite des Aspergillus, Institut Pasteur, Paris F 75015, France
    Nature 460:1117-21. 2009
    ..used several fungal members of the airborne microflora, including the human opportunistic fungal pathogen Aspergillus fumigatus, in in vitro assays with dendritic cells and alveolar macrophages and in in vivo murine experiments. In A...
  5. pmc Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
    Taylor R T Dagenais
    Medical Microbiology and Immunology, University of Wisconsin Madison, 3467 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA
    Clin Microbiol Rev 22:447-65. 2009
    ..Among them, Aspergillus fumigatus is the most prevalent and is largely responsible for the increased incidence of invasive aspergillosis (IA)..
  6. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    b>Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: iron uptake mediated by the extracellular siderophore triacetylfusarinine C and reductive iron assimilation...
  7. pmc Global transcriptome changes underlying colony growth in the opportunistic human pathogen Aspergillus fumigatus
    John G Gibbons
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Eukaryot Cell 11:68-78. 2012
    b>Aspergillus fumigatus is the most common and deadly pulmonary fungal infection worldwide. In the lung, the fungus usually forms a dense colony of filaments embedded in a polymeric extracellular matrix...
  8. pmc The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
    Radhika Jain
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Mol Microbiol 82:39-53. 2011
    The saprophytic fungus Aspergillus fumigatus is the most important air-borne fungal pathogen. The cell wall of A. fumigatus has been studied intensively as a potential target for development of effective antifungal agents...
  9. pmc Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia
    Martin Vödisch
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute and Friedrich Schiller University, Jena, Germany
    J Proteome Res 10:2508-24. 2011
    The mold Aspergillus fumigatus is the most important airborne fungal pathogen. Adaptation to hypoxia represents an important virulence attribute for A. fumigatus...
  10. ncbi Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus
    Céline M O'Gorman
    UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 457:471-4. 2009
    b>Aspergillus fumigatus is a saprotrophic fungus whose spores are ubiquitous in the atmosphere...
  11. ncbi Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    J D Pollock
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    Nat Genet 9:202-9. 1995
    ..superoxide production, manifested an increased susceptibility to infection with Staphylococcus aureus and Aspergillus fumigatus and had an altered inflammatory response in thioglycollate peritonitis...
  12. ncbi NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus
    Allison McCormick
    Max von Pettenkofer Institute, Ludwig Maximilians University, Pettenkoferstr 9a, D 80336, Munich, Germany
    Microbes Infect 12:928-36. 2010
    ..Our results show that conidia and germ tubes of the human pathogenic mold Aspergillus fumigatus are able to trigger the formation of NETs...
  13. pmc Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus
    Kwame Twumasi-Boateng
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Eukaryot Cell 8:104-15. 2009
    ..We examined the gene regulatory roles of the Aspergillus fumigatus developmental transcription factors StuAp and BrlAp during conidiation...
  14. pmc Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase
    Najwane Saïd-Sadier
    Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, USA
    PLoS ONE 5:e10008. 2010
    ..IA) is a life-threatening disease that occurs in immunodepressed patients when infected with Aspergillus fumigatus. This fungus is the second most-common causative agent of fungal disease after Candida albicans...
  15. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    b>Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A...
  16. pmc Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus
    Jessica L Werner
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 182:4938-46. 2009
    ..increases the incidence of invasive fungal infections, particularly those caused by the opportunistic mold Aspergillus fumigatus. Previous investigations revealed that members of the TLR family are not absolutely required for host ..
  17. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..Ptx3 binds selected microbial agents, including conidia of Aspergillus fumigatus, and we found that susceptibility of Ptx3-null mice was associated with defective recognition of conidia ..
  18. pmc Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA
    Sandra Bruns
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
    PLoS Pathog 6:e1000873. 2010
    b>Aspergillus fumigatus is the most important airborne fungal pathogen causing life-threatening infections in immunocompromised patients...
  19. ncbi Aspergillus fumigatus: contours of an opportunistic human pathogen
    Allison McCormick
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Cell Microbiol 12:1535-43. 2010
    b>Aspergillus fumigatus is currently the major air-borne fungal pathogen. It is able to cause several forms of disease in humans of which invasive aspergillosis is the most severe...
  20. ncbi Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability
    Isabelle Mouyna
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux 75724 Paris Cedex 15, France
    Mol Microbiol 76:1205-21. 2010
    ..this study, we characterized for the first time the whole PMT family of a pathogenic filamentous fungus, Aspergillus fumigatus. Genome analysis showed that only one member of each subfamily is present in A...
  21. ncbi Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein
    Dirk Wartenberg
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Jena, Germany
    Int J Med Microbiol 301:602-11. 2011
    Surface-associated and secreted proteins represent primarily exposed components of Aspergillus fumigatus during host infection...
  22. pmc Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009
    Jan W M van der Linden
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 17:1846-54. 2011
    The prevalence and spread of azole resistance in clinical Aspergillus fumigatus isolates in the Netherlands are currently unknown...
  23. pmc Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Pathog 1:e30. 2005
    ..We investigated the murine inflammatory response to conidia of Aspergillus fumigatus, the most common invasive mold in immunocompromised hosts...
  24. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
    ..transcriptional remodeling required for adaption to iron starvation in the opportunistic fungal pathogen Aspergillus fumigatus. HapX represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, ..
  25. ncbi Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies
    Georgios Chamilos
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Med Mycol 48:506-10. 2010
    The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A...
  26. pmc A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus
    Daryl L Richie
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS Pathog 5:e1000258. 2009
    ..To determine the contribution of the UPR to the growth and virulence of the filamentous fungal pathogen Aspergillus fumigatus, we disrupted the hacA gene, encoding the major transcriptional regulator of the UPR...
  27. ncbi Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms
    P Borger
    Laboratory of Allergology and Pulmonology, Department of Pathology, University Hospital Groningen, 9713 GZ Groningen, The Netherlands
    J Infect Dis 180:1267-74. 1999
    Proteases secreted by Aspergillus fumigatus induce the production of cytokines by epithelial cells, including interleukin (IL)-6 and IL-8. In the present study, we focused on the mechanism(s) by which A...
  28. ncbi The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response
    Vito Valiante
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Fungal Genet Biol 45:618-27. 2008
    ..Bioinformatic analysis of the genome of the most prevalent airborne human pathogenic fungus Aspergillus fumigatus, revealed the presence of four distinct MAPK-encoding genes...
  29. ncbi Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  30. pmc Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages
    O Ibrahim-Granet
    Unite des Aspergillus, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:891-903. 2003
    b>Aspergillus fumigatus is the most prevalent airborne fungal pathogen responsible for fatal invasive aspergillosis in immunocompromised patients. Upon arrival in the lung alveolus, conidia of A...
  31. pmc LaeA, a regulator of morphogenetic fungal virulence factors
    Jin Woo Bok
    University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 4:1574-82. 2005
    ..b>Aspergillus fumigatus, an increasingly serious pathogen owing to expanding numbers of immunocompromised patients, causes the ..
  32. pmc The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus
    Chad Steele
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    PLoS Pathog 1:e42. 2005
    Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage recognition receptor is critical for innate ..
  33. pmc Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure
    Susan J Howard
    Regional Mycology Laboratory, Manchester, UK
    Emerg Infect Dis 15:1068-76. 2009
    ..Azole resistance in A. fumigatus is an emerging problem and may develop during azole therapy...
  34. ncbi Aspergillus fumigatus: saprophyte or pathogen?
    Fredj Tekaia
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927, Universite Pierre et Marie Curie, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France
    Curr Opin Microbiol 8:385-92. 2005
    Large-scale genome comparisons have shown that no gene sets are shared exclusively by both Aspergillus fumigatus and any other human pathogen sequenced to date, such as Candida or Cryptococcus species...
  35. pmc A novel glyco-conjugate vaccine against fungal pathogens
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Exp Med 202:597-606. 2005
    ..Remarkably, Lam-CRM-vaccinated mice also were protected from a lethal challenge with conidia of Aspergillus fumigatus, and their serum also bound to and markedly inhibited the growth of A. fumigatus hyphae...
  36. pmc The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A
    Ana Paula Moreira
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Clin Invest 121:4420-32. 2011
    ..we explored the mechanism or mechanisms through which TLR6 mediates this effect using mouse models of Aspergillus fumigatus-induced and house dust mite antigen-induced (HDM antigen-induced) chronic asthma...
  37. ncbi Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence
    Jacob Romano
    Department of Human Microbiology, Sackler School of Medicine, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Microbiology 152:1919-28. 2006
    ..In this work, AfuEcm33, the gene encoding the ECM33 homologue in the important pathogenic fungus Aspergillus fumigatus, has been cloned and its function analysed...
  38. pmc Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Cell Mol Immunol 7:459-70. 2010
    ..Thus, distinct immune pathways contribute to resistance and tolerance to the fungus, to which the hematopoietic/non-hematopoietic compartments contribute through distinct, yet complementary, roles...
  39. ncbi cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages
    B Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Am Schneiderberg 50, 30167 Hannover, Germany
    Mol Genet Genomics 269:420-35. 2003
    b>Aspergillus fumigatus is an important pathogen of immunocompromised hosts, causing pneumonia and invasive disseminated disease and resulting in high mortality...
  40. pmc Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus
    Sabiha Yasmin
    Division of Molecular Biology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 109:E497-504. 2012
    b>Aspergillus fumigatus is the most common airborne fungal pathogen for humans. In this mold, iron starvation induces production of the siderophore triacetylfusarinine C (TAFC)...
  41. ncbi Biosynthesis and function of gliotoxin in Aspergillus fumigatus
    Daniel H Scharf
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Beutenbergstr 11a, 07745, Jena, Germany
    Appl Microbiol Biotechnol 93:467-72. 2012
    ..GT plays a critical role in the pathobiology of Aspergillus fumigatus. It modulates the immune response and induces apoptosis in different cell types...
  42. pmc Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain
    Klaus Leth Mortensen
    Mycology Unit, Department of Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark
    Antimicrob Agents Chemother 54:4545-9. 2010
    A single mechanism of azole resistance was shown to predominate in clinical and environmental Aspergillus fumigatus isolates from the Netherlands, and a link to the use of azoles in the environment was suggested...
  43. pmc Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence
    Ilse D Jacobsen
    Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Infect Immun 78:2995-3006. 2010
    ..Our results suggest that embryonated eggs can be a very useful alternative infection model to study A. fumigatus virulence and pathogenicity...
  44. pmc The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 5:207-11. 2006
    To increase the frequency of homologous recombination, we inactivated the KU80 homologue in Aspergillus fumigatus (named akuB(KU80))...
  45. pmc Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA
    Zaida G Ramirez-Ortiz
    Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Infect Immun 76:2123-9. 2008
    Phagocytic defenses are critical for effective host defenses against the opportunistic fungal pathogen Aspergillus fumigatus. Previous studies found that following challenge with A...
  46. ncbi Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus
    Janka Teutschbein
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Jena, Germany
    J Proteome Res 9:3427-42. 2010
    b>Aspergillus fumigatus is a ubiquitously distributed filamentous fungus that has emerged as one of the most serious life-threatening pathogens in immunocompromised patients. The mechanisms for its pathogenicity are poorly understood...
  47. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
    Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen...
  48. ncbi Molecular organization of the alkali-insoluble fraction of Aspergillus fumigatus cell wall
    T Fontaine
    Laboratoire des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 275:27594-607. 2000
    ..We have analyzed the alkali-insoluble fraction of the Aspergillus fumigatus cell wall, which is the fraction believed to be responsible for fungal cell wall rigidity...
  49. pmc The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Infect Immun 72:5193-203. 2004
    b>Aspergillus fumigatus is an important pathogen of immunocompromised hosts, causing pneumonia and invasive disseminated disease with high mortality...
  50. ncbi Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states
    Geoffrey M Gersuk
    Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    J Immunol 176:3717-24. 2006
    b>Aspergillus fumigatus is a common cause of invasive and allergic pulmonary disease. Resting conidia of the filamentous fungus are constantly inhaled, but cause infection only after initiating hyphal growth...
  51. pmc A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
    E Mellado
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo Km2, 28220 Madrid, Spain
    Antimicrob Agents Chemother 51:1897-904. 2007
    Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced susceptibility to triazole drugs were analyzed...
  52. pmc Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism
    Eveline Snelders
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Med 5:e219. 2008
    Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. fumigatus is unknown...
  53. ncbi Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2
    Kathrin Luther
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
    Cell Microbiol 9:368-81. 2007
    b>Aspergillus fumigatus is a fungal pathogen causing severe infections in immunocompromised patients. For clearance of inhaled conidia, an efficient response of the innate immune system is required...
  54. pmc The Aspergillus Genome Database (AspGD): recent developments in comprehensive multispecies curation, comparative genomics and community resources
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D653-9. 2012
    ..have now completed comprehensive review of the entire published literature about Aspergillus nidulans and Aspergillus fumigatus, and this annotation is provided with streamlined, ortholog-based navigation of the multispecies ..
  55. ncbi Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release
    Maria Bouzani
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, 97080 Wurzburg, Germany
    J Immunol 187:1369-76. 2011
    ..there is a relative lack of data on the interplay between NK cells and filamentous fungi, especially Aspergillus fumigatus, which is the major cause of invasive aspergillosis...
  56. ncbi Gbetagamma-mediated growth and developmental control in Aspergillus fumigatus
    Kwang Soo Shin
    Department of Microbiology and Biotechnology, Daejeon University, Daejon, Republic of Korea
    Curr Genet 55:631-41. 2009
    The roles of the Gbetagamma subunits of the opportunistic human pathogen Aspergillus fumigatus were investigated...
  57. pmc Iron homeostasis--Achilles' heel of Aspergillus fumigatus?
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Curr Opin Microbiol 14:400-5. 2011
    The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron...
  58. pmc SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus
    Michael Blatzer
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Genet 7:e1002374. 2011
    ..importance of SREBPs in human health, SREBPs in the human fungal pathogens Cryptococcus neoformans and Aspergillus fumigatus are required for fungal virulence and susceptibility to triazole antifungal drugs...
  59. pmc Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia
    Marc Pihet
    Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire d Angers, France
    BMC Microbiol 9:177. 2009
    b>Aspergillus fumigatus is the most common agent of invasive aspergillosis, a feared complication in severely immunocompromised patients...
  60. pmc Immune responses against Aspergillus fumigatus: what have we learned?
    Robert A Cramer
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    Curr Opin Infect Dis 24:315-22. 2011
    b>Aspergillus fumigatus causes invasive and allergenic disease...
  61. pmc IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma
    Abbie Fairs
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, UK
    Am J Respir Crit Care Med 182:1362-8. 2010
    The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear.
  62. pmc Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis
    Hong Liu
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Mol Microbiol 78:1038-54. 2010
    Relatively few transcription factors that govern the virulence of Aspergillus fumigatus are known. We constructed 11 A. fumigatus transcription factor mutants and screened them for altered virulence in Galleria mellonella larvae...
  63. pmc A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus
    Jarrod R Fortwendel
    Department of Pathology and Laboratory Medicine, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    Eukaryot Cell 4:1982-9. 2005
    ..In a previous study, we identified a gene encoding a fungus-specific Ras subfamily homolog, rasB, in Aspergillus fumigatus. Here we report that deletion of A...
  64. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1...
  65. ncbi Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus
    Federica Moalli
    Laboratory of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Rozzano, Milan, Italy
    Blood 116:5170-80. 2010
    ..3 (PTX3) is a soluble pattern recognition molecule playing a nonredundant role in resistance against Aspergillus fumigatus. The present study was designed to investigate the molecular pathways involved in the opsonic activity of ..
  66. ncbi The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo
    Silvia Bellocchio
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 172:3059-69. 2004
    ..importance of Toll-like receptor (TLR) signaling in response to the fungal pathogens Candida albicans and Aspergillus fumigatus. However, the functional consequences of the complex interplay between fungal morphogenesis and TLR ..
  67. ncbi Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus
    Olaf Beck
    Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Blood 107:2562-9. 2006
    ..secretion assay, we isolated human activated T cells upon stimulation with a cellular extract of Aspergillus fumigatus. Culturing this cell population for 14 days, we obtained an average of 1...
  68. pmc Early events in macrophage killing of Aspergillus fumigatus conidia: new flow cytometric viability assay
    K A Marr
    Fred Hutchinson Cancer Research Center Program in Infectious Diseases, Seattle, Washington 98109, USA
    Clin Diagn Lab Immunol 8:1240-7. 2001
    Detailed investigations of macrophage phagocytosis and killing of Aspergillus fumigatus conidia have been limited by technical difficulties in quantifying fungal uptake and viability...
  69. pmc Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice
    Hemanth Ramaprakash
    Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Infect Immun 77:108-19. 2009
    ..TLR9 wild-type (TLR9(+/+)) and TLR9-deficient (TLR9(-/-)) mice were challenged with resting or swollen Aspergillus fumigatus conidia and monitored for survival and lung inflammatory responses...
  70. ncbi TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients
    Agostinho Carvalho
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
    Blood 119:967-77. 2012
    b>Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8⁺ T cells are present in the human and murine T-cell repertoire to the fungus...
  71. pmc Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach
    Jörg Linde
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    BMC Syst Biol 6:6. 2012
    ..b>Aspergillus fumigatus is a major human fungal pathogen...
  72. ncbi The characteristics of Aspergillus fumigatus mycetoma development: is this a biofilm?
    Eilidh Mowat
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK
    Med Mycol 47:S120-6. 2009
    b>Aspergillus fumigatus is an increasingly prevalent opportunistic fungal pathogen of various immuno-compromised individuals. It has the ability to filament within the lungs forming dense intertwined mycelial balls...
  73. pmc Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus
    Robert A Cramer
    Duke University Medical Center, Box 3499, Pediatric Infectious Diseases, Durham, NC 27710, USA
    Eukaryot Cell 7:1085-97. 2008
    ..factor Crz1 homolog (CrzA) in the physiology and pathogenicity of the opportunistic human fungal pathogen Aspergillus fumigatus. Genetic replacement of the crzA locus in A...
  74. ncbi Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans
    Claudia Stuehler
    Department of Internal Medicine II, Division of Hematology, University of Wurzburg, Wurzburg, Germany
    Blood 117:5881-91. 2011
    ..b>Aspergillus fumigatus and Candida albicans, the 2 most common fungal pathogens causing severe infections in immunocompromised ..
  75. ncbi Phagocyte responses towards Aspergillus fumigatus
    Mike Hasenberg
    Otto von Guericke University Magdeburg, Institute for Molecular and Clinical Immunology, Leipziger Str 44, 39120 Magdeburg, Germany
    Int J Med Microbiol 301:436-44. 2011
    The saprophytic fungus Aspergillus fumigatus is a mold which is ubiquitously present in the environment. It produces large numbers of spores, called conidia that we constantly inhale with the breathing air...
  76. pmc Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus
    Brian D Ames
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States
    Biochemistry 50:8756-69. 2011
    The human pathogen Aspergillus fumigatus makes a series of fumiquinazoline (FQ) peptidyl alkaloids of increasing scaffold complexity using L-Trp, 2 equiv of L-Ala, and the non-proteinogenic amino acid anthranilate as building blocks...
  77. pmc Aspergillus fumigatus forms biofilms with reduced antifungal drug susceptibility on bronchial epithelial cells
    Marc J Seidler
    Department of Pediatrics III, Cystic Fibrosis Centre and Infectious Diseases, University of Heidelberg, Heidelberg, Germany
    Antimicrob Agents Chemother 52:4130-6. 2008
    b>Aspergillus fumigatus is a leading cause of death in immunocompromised patients and a frequent colonizer of the respiratory tracts of asthma and cystic fibrosis (CF) patients...
  78. ncbi Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice
    J L Slater
    School of Translational Medicine, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK
    Med Mycol 49:S107-13. 2011
    b>Aspergillus fumigatus is a clinically important fungus with the ability to cause invasive aspergillosis with high mortality rates in immunocompromised patients and chronic pulmonary aspergillosis in immunocompetent individuals...
  79. pmc What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?
    Kyung J Kwon-Chung
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Med Mycol 47:S97-103. 2009
    ..the epipolythiodioxopiperazine class of toxins and is both the major and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the putative gliotoxin biosynthetic 12-gene cluster in the genome of A...
  80. pmc The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model
    Franziska Lessing
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
    Eukaryot Cell 6:2290-302. 2007
    Macrophages and neutrophils kill the airborne fungal pathogen Aspergillus fumigatus. The dependency of this killing process on reactive oxygen intermediates (ROI) has been strongly suggested...
  81. ncbi Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus
    Martin Vödisch
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
    Proteomics 9:1407-15. 2009
    The filamentous fungus Aspergillus fumigatus has become the most important airborne fungal pathogen causing life-threatening infections in immunosuppressed patients. We established a 2-D reference map for A. fumigatus...
  82. ncbi Galactofuranose containing molecules in Aspergillus fumigatus
    Jean Paul Latge
    Aspergillus Unit, Institut Pasteur, Paris, France
    Med Mycol 47:S104-9. 2009
    Galactofuranose is a major carbohydrate in Aspergillus fumigatus. It became famous in medical mycology as being part of the galactomannan which was shown 30 years ago to be the major antigen circulating in the body fluid of patients ..
  83. pmc The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 12:1035-41. 2010
    ..To ensure an adequate supply with iron, Aspergillus fumigatus employs extra- and intracellular siderophores (low-molecular mass iron chelators), which are of importance ..
  84. pmc Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae
    J E Wang
    Institute for Surgical Research, Rikshospitalet National Hospital, N 0027 Oslo, Norway
    Infect Immun 69:2402-6. 2001
    ..Incubation of whole human blood with hyphal fragments from Aspergillus fumigatus and Scedosporium prolificans for 6 h caused induction of mRNAs for tumor necrosis factor alpha (TNF-alpha),..
  85. pmc Integrative analysis of the heat shock response in Aspergillus fumigatus
    Daniela Albrecht
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    BMC Genomics 11:32. 2010
    b>Aspergillus fumigatus is a thermotolerant human-pathogenic mold and the most common cause of invasive aspergillosis (IA) in immunocompromised patients. Its predominance is based on several factors most of which are still unknown...
  86. ncbi FungiFun: a web-based application for functional categorization of fungal genes and proteins
    Steffen Priebe
    Research group Systems Biology Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Jena, Germany
    Fungal Genet Biol 48:353-8. 2011
    ..Two biological datasets for Aspergillus fumigatus and Candida albicans were analyzed using FungiFun, providing an overview of the usage and functions of the ..
  87. ncbi Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth
    Steven B Levery
    Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA
    FEBS Lett 525:59-64. 2002
    The opportunistic mycopathogen Aspergillus fumigatus expresses both glucosylceramide and galactosylceramide (GlcCer and GalCer), but their functional significance in Aspergillus species is unknown...
  88. ncbi Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus
    Justyna Karkowska-Kuleta
    Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 56:211-24. 2009
    ..is focused on major virulence factors of the most common fungal pathogens of humans: Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans...
  89. ncbi Functional analysis of the superoxide dismutase family in Aspergillus fumigatus
    Karine Lambou
    Unite des Aspergillus, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 75:910-23. 2010
    Reactive oxidant species produced by phagocytes have been reported as being involved in the killing of Aspergillus fumigatus. Fungal superoxide dismutases (SODs) that detoxify superoxide anions could be putative virulence factors for ..
  90. pmc Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, Jena, Germany
    Infect Immun 78:3585-94. 2010
    The opportunistic human pathogenic fungus Aspergillus fumigatus is a major cause of fungal infections in immunocompromised patients. Innate immunity plays an important role in the defense against infections...
  91. pmc Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin
    Markus Schrettl
    Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    PLoS Pathog 6:e1000952. 2010
    ..towards mammalian cells, gliotoxin has come to be considered as a component of the virulence arsenal of Aspergillus fumigatus. Here we show that deletion of a single gene, gliT, in the gliotoxin biosynthetic cluster of two A...
  92. ncbi Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus
    Michelle Oppenheimer
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Arch Biochem Biophys 502:31-8. 2010
    ..to UDP-galactofuranose, the precursor of galactofuranose, which is an important cell wall component in Aspergillus fumigatus and other pathogenic microbes. A...
  93. ncbi Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery
    Caspar J Hodiamont
    Department of Medical Microbiology, Academic Medical Center, Amsterdam
    Med Mycol 47:217-20. 2009
    We describe a patient with chronic granulomatous disease and proven Aspergillus fumigatus osteomyelitis of the midfoot, while receiving itraconazole-prophylaxis...
  94. ncbi Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus
    Corina Costachel
    Unite des Aspergillus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 280:39835-42. 2005
    Galactomannan is a characteristic polysaccharide of the human filamentous fungal pathogen Aspergillus fumigatus that can be used to diagnose invasive aspergillosis...
  95. ncbi Aspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organization
    Amandine Gastebois
    Unite des Aspergillus, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Future Microbiol 4:583-95. 2009
    b>Aspergillus fumigatus is the most prevalent thermophilic inhabitants of decaying vegetation and one of the most important human opportunistic fungal pathogens. Like other fungi, A...
  96. ncbi PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages
    Bernhard Jahn
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    Cell Microbiol 4:793-803. 2002
    Previously, we described the isolation of an Aspergillus fumigatus mutant producing non-pigmented conidia, as a result of a defective polyketide synthase gene, pksP (polyketide synthase involved in pigment biosynthesis)...
  97. pmc Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence
    Alexander Gehrke
    Department of Microbiology and Molecular Biology, Friedrich Schiller University Jena, Germany
    Appl Environ Microbiol 76:3989-98. 2010
    The filamentous fungus Aspergillus fumigatus normally grows on compost or hay but is also able to colonize environments such as the human lung. In order to survive, this organism needs to react to a multitude of external stimuli...
  98. ncbi Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?
    Paul E Verweij
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Lancet Infect Dis 9:789-95. 2009
    Invasive aspergillosis due to multi-azole-resistant Aspergillus fumigatus has emerged in the Netherlands since 1999, with 6.0-12.8% of patients harbouring resistant isolates...
  99. pmc HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus
    Xizhi Feng
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS Pathog 7:e1002330. 2011
    ..Here, we examined the contribution of IreA to growth and virulence in the human fungal pathogen Aspergillus fumigatus. Gene expression profiling revealed that A...
  100. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ....
  101. pmc Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles
    Eveline Snelders
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, The Netherlands
    Appl Environ Microbiol 75:4053-7. 2009
    We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis...

Research Grants73

  1. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..coli flavohemoglobin and a series of fungal (Candida albicans and Aspergillus fumigatus) flavohemoglobins, which catalyze this reaction as part of a defense mechanism against host-induced ..
  2. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..The most common causative agent of IA is Aspergillus fumigatus, a mold frequently present in the environment...
  3. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is associated with mortality rates of 40- 50%...
  4. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..The InMAD strategy is based on the hypothesis that serum or urine from mice infected with Aspergillus fumigatus will contain precisely those fungal proteins that would be targets for immunoassay. Serum or urine from A...
  5. Identification and Analysis of Circadian Clock-Controlled Genes
    Jennifer J Loros; Fiscal Year: 2013
    ..We will extend analysis of photobiology to the important fungal pathogen Aspergillus fumigatus where we can envision a way to exploit our understanding of fungal photobiology to enable a new treatment ..
  6. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..and the beta-glucan receptor Dectin-1 in the development of allergy or tolerance to the ubiquitous fungus Aspergillus fumigatus. These studies will be conducted in the context of a cohort of patients with Cystic Fibrosis that have ..
  7. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    Infections caused by Aspergillus fumigatus are a leading cause of death in immune compromised individuals. A...
  8. Novel antifungals for Immunocompromised/HIV patients.
    ESTEBAN EDWARD MENA; Fiscal Year: 2011
    ..against both fluconazole sensitive (ATCC 90028) and resistant Candida strains ATCC 90030, 96901, 6852) and Aspergillus fumigatus and Cryptococcus neoformans...
  9. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The respiratory immune system clears hundreds of airborne Aspergillus fumigatus spores (conidia) daily...
  10. Immune Dysregulation in Uremia
    Neal B Blatt; Fiscal Year: 2013
    ..third specific aim, the immune systems of SNx and control mice will be challenged in vivo with the fungus Aspergillus fumigatus, which will serve as a model organism to probe pro-inflammatory immune responses that depend upon the ..
  11. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is the major filamentous fungal pathogen in humans...
  12. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is the most common cause of invasive mold infections. Even with advances in therapy and early diagnostics, mortality rates remain high...
  13. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2013
    ABSTRACT With the rise in susceptible individuals, the burden of disease due to Aspergillus fumigatus has increased substantially...
  14. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..albicans or Aspergillus fumigatus. Therefore, ATAK cells are capable of recapitulating neutrophil host-defense functions in vitro and in ..
  15. Mechanisms of Host Adaptation for Candida albicans
    PETER JOHN ESPENSHADE; Fiscal Year: 2013
    ..In fungal pathogens such as Cryptococcus neoformans and Aspergillus fumigatus, the membrane-bound sterol regulatory element binding protein (SREBP) is a key hypoxic transcription ..
  16. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT cells, resulting in innate and adaptive mucosal immune responses...
  17. Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutases
    Pablo Sobrado; Fiscal Year: 2013
    ..Deletion of the UGM gene results in severely attenuated virulence of the fungal pathogen Aspergillus fumigatus and the protozoan parasite Leishmania major, suggesting UGM as a promising drug design target...
  18. Identification of calcineurin-binding proteins in A. fumigatus septum formation
    William J Steinbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus has surpassed invasive candidiasis as the most frequent fungal cause of death in immunocompromised patients...
  19. Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
    Jatin M Vyas; Fiscal Year: 2013
    ..pathways remained intact 3) CD82 is recruited to phagosomes containing fungal pathogens including Aspergillus fumigatus as determined by time-lapse imaging of a fluorescentlytagged version of CD82 expressed in primary DCs ..
  20. Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucin
    John V Fahy; Fiscal Year: 2012
    ..Sputum in CF is frequently infected with Pseudomonas aeruginosa and Aspergillus fumigatus, and these organisms contribute to the abnormal viscoelastic properties of the airway mucus that ..
  21. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..including Streptococcus pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT cells, resulting in innate and adaptive mucosal immune responses...
  22. Novel Biomarkers for Early Detection of Aspergillosis
    Ram Ramabhadran; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients...
  23. Control of Aspergillus fumigatus polarized growth through regulation of Ras prote
    Jarrod Fortwendel; Fiscal Year: 2013
    ..b>Aspergillus fumigatus is a commonly isolated, opportunistic mould. The conidia of A...
  24. TAS::75 0862::TAS
    Martin D Chapman; Fiscal Year: 2010
    ..Array for Mold Biomarkers (MAMB) on the xMAP system to measure allergens/antigens from Alternaria, Aspergillus fumigatus, A. versicolor, Stachybotrys and Penicillium spp...
  25. Aspergillus-specific CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2010
    b>Aspergillus fumigatus is a clinically important fungal pathogen that causes invasive disease in immunocompromised hosts...
  26. CD1d and NKT Cell Activation and Function in Infection
    Michael B Brenner; Fiscal Year: 2013
    ..We have found that several common fungal pathogens such as Candida albicans and Aspergillus fumigatus efficiently activate iNKT cells...
  27. The role of TLR9 on Aspergillus fumigatus phagosomes
    Jatin M Vyas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is a saprophytic filamentous fungus whose asexual spores called conidia are widespread in the environment, acquired through inhalation and small enough to reach the distal ..
  28. Transcriptional regulation of A. fumigatus virulence
    Scott G Filler; Fiscal Year: 2013
    ..A critical step in the pathogenesis o invasive aspergillosis is the interaction of Aspergillus fumigatus with pulmonary epithelial cells. After being inhaled, A...
  29. Biosynthesis of HSAF, an antifungal natural product with a novel mode of action
    Liangcheng Du; Fiscal Year: 2009
    ..potent activities against a wide range of fungal species, including the life-threatening human pathogen, Aspergillus fumigatus, and shows a novel mode of action by disrupting the polarized growth of filamentous fungi...
  30. The systems biology of iron homeostasis and the immune response to Aspergillus
    CHRISTOPHER BRIAN LAWRENCE; Fiscal Year: 2013
    ..The specific aims of this project are designed to better understand the biology and virulence of Aspergillus fumigatus, the causative agent of invasive aspergillosis (IA), the host immune response, and the role of iron in the ..
  31. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive pulmonary aspergillosis caused by the mold Aspergillus fumigatus has emerged as one of the most severe invasive fungal infections, not only in an expanding population of immunosuppressed ..
  32. Innovative Assay Development for the Diagnosis of Invasive Aspergillosis
    Marc D Porter; Fiscal Year: 2012
    ..This R21 grant application will advance this concept using Aspergillus fumigatus (A. fumigatus) - the most common cause of IA - as the proof-of-principle target...
  33. Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    William J Steinbach; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is a leading cause of death in immunocompromised patients. Current IA therapy has a disappointing treatment success rate...
  34. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Humans inhale ubiquitous Aspergillus fumigatus conidia on a daily basis...
  35. Dectin-1 and Invasive Pulmonary Aspergillosis
    Chad Steele; Fiscal Year: 2010
    ..results in a significant predisposition to invasive fungal infections, particularly those caused by Aspergillus fumigatus. We have previously reported that interruption of recognition by the beta-glucan receptor Dectin-1 ..
  36. Control of Airway Tolerance
    Michael Croft; Fiscal Year: 2013
    ..allergens associated with asthma, from Dermatophagoides pteronyssinus, a house dust mite (HDM), and from Aspergillus fumigatus, a fungus...
  37. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
    ..These aims will utilize VPAC2 wild type (C57BL/6) and knockout mice in an inhalation model of Aspergillus fumigatus allergic asthma that was developed by our research team...
  38. The Pathogenesis of Aspergillus Keratitis
    SIXTO MANUEL LEAL; Fiscal Year: 2012
    ..of this proposal is to identify potential anti-inflammatory and anti-fungal therapeutic targets during Aspergillus fumigatus infection in the cornea. We propose to do this by using mouse models of A...
  39. High-density lipoprotein and A. fumigatus pathogenesis
    David S Askew; Fiscal Year: 2013
    ..the defense against invasive aspergillosis (IA), a life-threatening infection caused by the mold pathogen Aspergillus fumigatus. The most abundant protein found in HDL is apolipoprotein A-I (apoA-I), a lipid-binding molecule that ..
  40. ER stress and virulence of Aspergillus fumigatus
    David S Askew; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is an important opportunistic fungal pathogen that has become the leading infectious mould of immunocompromised patients...
  41. Clinical and Molecular Phenotypes of Severe Asthma
    John V Fahy; Fiscal Year: 2013
    ..Included in the lectins we will study will be Aspergillus fumigatus lectin, a fucose binding lectin that we hypothesize to have a pathogenic role in the mechanism of mucus ..
  42. Decoding the pathogenic interactome of Aspergillus fumigatus
    Nancy P Keller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is a serious medical menace and ranks as the most severe filamentous mold causing human disease with 60% overall reported fatality...
  43. Novel antifungal therapeutics
    WILLIAM CONSTANTINE GROUTAS; Fiscal Year: 2012
    ..upon preliminary data that indicate high susceptibilities to our compounds among several Candida species, Aspergillus fumigatus, and C. neoformans...
  44. CD1d and NKT Cell Activation and Function in Infection
    Michael B Brenner; Fiscal Year: 2010
    ..We have found that the fungal pathogen, Aspergillus fumigatus, efficiently activates iNKT cells by the indirect, cytokine-driven mechanism...
  45. Linking Triazole Resistance and Fitness in Aspergillus fumigatus
    David S Perlin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus causes a wide spectrum of diseases including allergic syndromes, chronic pulmonary aspergillosis and acute invasive aspergillosis (IA)...
  46. Ether Lipids, Elcosanoids, and Lung Cell Pathophysiology
    CHRISTINA CARROLL LESLIE; Fiscal Year: 2013
    ..and eicosanoid production in resident peritoneal and alveolar macrophages by Cantjida albicans and Aspergillus fumigatus, and determine the role of this pathway in regulating immune responses to fungal infection in the lung...
  47. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..For this purpose, Aspergillus fumigatus, a fungus that causes disease in patients with immunocompromised immune systems, has been selected as a ..
  48. Characterizing the genomic patterns of variation in the fungal pathogen Aspergill
    John G Gibbons; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Aspergillus fumigatus lives primarily as a saprobe but has become an emerging opportunistic human pathogen with mortality rates reaching 50%...
  49. Immune regulatory mechanisms and fungus-specific memory T cell responses
    Vanessa Espinosa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The opportunistic fungal pathogen Aspergillus fumigatus is the causative agent of more than 90% of all Invasive Aspergillosis (IA) infections diagnosed in immunosuppressed patients. Exposure to A...
  50. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..albicans yeast and hyphal forms. MDR gene fragments will be amplified from Candida glabrata, Aspergillus fumigatus, and Cryptococcus neoformans and used as probes for MDR induction studies in those fungi...
  51. Cellular Mechanisms Governing an Invasive Aspergillosis Virulence Factor
    Graeme S Garvey; Fiscal Year: 2010
    ..Impairment of secondary metabolite production in the opportunistic human pathogen Aspergillus fumigatus by deletion of a global regulatory gene, laeA, reduces this organism's virulence...
  52. A Phylogenetic Approach to Virulence in Aspergillus
    Paul Bayman; Fiscal Year: 2012
    ..The most common pathogens, Aspergillus fumigatus and A...
  53. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ..The approach has been to study immune responses to two fungi: Aspergillus fumigatus that commonly grows in the respiratory tract, and dermatophytes of the genus Trichophyton that grow on the ..
  54. Study of the veA Gene in the Human Pathogen Aspergillus fumigatus
    Baohua Wang; Fiscal Year: 2012
    ..In this proposal the PI will focus on the human pathogen, Aspergillus fumigatus. Regulatory signaling genes tend to be conserved among fungal species...
  55. Natural Th17 cells in allergic airway disease
    Martha S Jordan; Fiscal Year: 2013
    ..In Aim 2, we will take advantage of our well-characterized model of Aspergillus fumigatus extract induced asthma to determine the contribution of nTh17 cells to asthma.
  56. Phoslactomycins: Biosynthesis & Activity
    Kevin A Reynolds; Fiscal Year: 2010
    ..The PLMs exhibit remarkably selectivity and potent activity against human fungal pathogens, including Aspergillus fumigatus. The DNA encoding the PLM and fostriecin biosynthetic processes have been cloned, sequenced and analyzed...
  57. Phoslactomycins: Biosynthesis &Activity
    Kevin A Reynolds; Fiscal Year: 2013
    ..The PLMs exhibit remarkably selectivity and potent activity against human fungal pathogens, including Aspergillus fumigatus. The DNA encoding the PLM and fostriecin biosynthetic processes have been cloned, sequenced and analyzed...
  58. Hypoxia Adapatation and Fungal Virulence of Aspergillus fumigatus
    ROBERT ANDREW CRAMER; Fiscal Year: 2012
    Invasive aspergillosis (IA) is caused by the mould Aspergillus fumigatus and is an understudied disease of growing significance that causes over 3,500 deaths in the United States annually. The spectrum of patients susceptible to A...
  59. Conditions for Rapid Mating in Aspergillus fumigatus
    Judith C Rhodes; Fiscal Year: 2012
    ..by applicant): This project will refine factors that define the protocol for mating compatible strains of Aspergillus fumigatus in order to decrease the time required to complete the meiotic cycle. A...
  60. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    ..hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af). It results in marked lung damage in patients with bronchial asthma or cystic fibrosis (CF)...
  61. ASPERGILLUS FUMIGATUS COMPLEMENT INHIBITOR
    RONALD WASHBURN; Fiscal Year: 1991
    A complement inhibitor (CI) produced by Aspergillus fumigatus selectively inhibited the alternative pathway. This was the first observation of a CI produced by a fungus which causes human disease...
  62. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...
  63. GENOME SEQUENCING OF ASPERGILLUS FUMIGATUS
    David Denning; Fiscal Year: 2001
    b>Aspergillus fumigatus is the most common cause of life-threatening mold infection (aspergillosis). Its spores are found in the air everywhere and are therefore unavoidable...
  64. FOCUSED PARALLEL SYNTHESIS OF DICATION ANTIFUNGAL AGENTS
    Richard Tidwell; Fiscal Year: 2003
    ..10 g/ml against both organisms. Our studies also demonstrated that the compounds were active against Aspergillus fumigatus, Fusarium solani, Candida species other than C. albicans and fluconazole-resistant strains of C...
  65. Ambruticin for Aspergillus
    Leonard Katz; Fiscal Year: 2005
    ..b>Aspergillus fumigatus, and other Aspergillus species account for about 70% of IMIs, the remainder caused by Scedosporium, ..
  66. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric G Pamer; Fiscal Year: 2010
    b>Aspergillus fumigatus is a spore forming mould that causes a range of human diseases, including allergic bronchopulmonary aspergillosis, an asthma-like disease, and invasive aspergillosis, a frequently fatal infection that occurs in ..
  67. Genetic Analysis of Echinocandin Sensitivity
    Santosh Katiyar; Fiscal Year: 2004
    ..While common fungal pathogens such as Candida albicans and Aspergillus fumigatus are susceptible to ECs, others such as Cryptococcus neoformans are intrinsically resistant for reasons ..
  68. TWO-COMPONENT SIGNAL PROTEINS OF ASPERGILLUS FUMIGATUS
    Richard Calderone; Fiscal Year: 2003
    ..seeks funding for a study of two-component signal transduction proteins from the human pathogenic fungus, Aspergillus fumigatus. The parent grant is entitled, "The response regulator gene (CaSSK1) of Candida albicans, 1 R0l A147047-01...
  69. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    b>Aspergillus fumigatus, a ubiquitous fungal pathogen, causes invasive disease in severely immunocompromised patients, most often in those with profound neutropenia or who have undergone organ transplantation...
  70. Functions, Traffic and Targeting of Fungal Adhesins
    SCOTT ERDMAN; Fiscal Year: 2003
    ..to the life cycles of many fungi pathogenic to humans including Candida species, Cryptococcus neoformans, Aspergillus fumigatus and Histoplasma capsulatum...
  71. DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 2002
    ..be recognized and used by opportunistic pathogens such as Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus (though many others will be included in broad screening)...
  72. ASPERGILLUS ALLERGENS AND ALLERGIC ASPERGILLOSIS
    Viswanath Kurup; Fiscal Year: 2000
    ..the applicant's abstract): The overall objectives of this project are to produce and characterize relevant Aspergillus fumigatus (Af) antigens for early diagnosis of Aspergillus and to understand the immunopathogenesis of allergic ..
  73. Phagocyte Contact Response in Aspergillosis Immunity
    JAMES BURRITT; Fiscal Year: 2005
    b>Aspergillus fumigatus is the leading airborne fungal pathogen in immune compromised people. Due to difficulties in managing A. fumigatus infections, most individuals that develop invasive aspergillosis will die...