aspergillus

Summary

Summary: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.

Top Publications

  1. pmc Aspergillus as a multi-purpose cell factory: current status and perspectives
    Vera Meyer
    Department of Molecular Microbiology and Biotechnology, Leiden University, Institute of Biology Leiden, Sylviusweg 72, 2333 BE, Leiden, The Netherlands
    Biotechnol Lett 33:469-76. 2011
  2. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
  3. ncbi Advances in Aspergillus secondary metabolite research in the post-genomic era
    James F Sanchez
    University of Southern California Pharmacology and Pharmaceutical Sciences, Los Angeles, California 90033, USA
    Nat Prod Rep 29:351-71. 2012
  4. ncbi Phylogenetic analysis of Aspergillus species using DNA sequences from four loci
    Stephen W Peterson
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, Peoria, Illinois 61604, USA
    Mycologia 100:205-26. 2008
  5. ncbi Production and characterization of cellulolytic enzymes from the thermoacidophilic fungal Aspergillus terreus M11 under solid-state cultivation of corn stover
    Jianmin Gao
    Department of Bioengineering, Zhengzhou University, 100 Kexue Road, Zhengzhou 450001, PR China
    Bioresour Technol 99:7623-9. 2008
  6. ncbi Apyap1 affects aflatoxin biosynthesis during Aspergillus parasiticus growth in maize seeds
    M Reverberi
    Universita degli Studi La Sapienza, 00165 Rome, Italy
    Food Addit Contam 24:1070-5. 2007
  7. pmc Potential basis for amphotericin B resistance in Aspergillus terreus
    Gerhard Blum
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 52:1553-5. 2008
  8. pmc CADRE: the Central Aspergillus Data REpository 2012
    Jane Mabey Gilsenan
    School of Translational Medicine, University of Manchester, Manchester M23 9LT, UK
    Nucleic Acids Res 40:D660-6. 2012
  9. ncbi Aspergillus niger contains the cryptic phylogenetic species A. awamori
    Giancarlo Perrone
    Institute of Sciences of Food Production ISPA, National Research Council CNR, Via G Amendola 122 o, 70126 Bari, Italy
    Fungal Biol 115:1138-50. 2011
  10. ncbi Developing Aspergillus as a host for heterologous expression
    David Lubertozzi
    Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
    Biotechnol Adv 27:53-75. 2009

Detail Information

Publications336 found, 100 shown here

  1. pmc Aspergillus as a multi-purpose cell factory: current status and perspectives
    Vera Meyer
    Department of Molecular Microbiology and Biotechnology, Leiden University, Institute of Biology Leiden, Sylviusweg 72, 2333 BE, Leiden, The Netherlands
    Biotechnol Lett 33:469-76. 2011
    ..The achievements made during the last years, however, have the potential to revolutionize Aspergillus biotechnology and to assure Aspergillus a dominant place among microbial cell factories...
  2. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ..We present here a novel Aspergillus nuclear protein, LaeA, as a global regulator of secondary metabolism in this genus...
  3. ncbi Advances in Aspergillus secondary metabolite research in the post-genomic era
    James F Sanchez
    University of Southern California Pharmacology and Pharmaceutical Sciences, Los Angeles, California 90033, USA
    Nat Prod Rep 29:351-71. 2012
    This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available...
  4. ncbi Phylogenetic analysis of Aspergillus species using DNA sequences from four loci
    Stephen W Peterson
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, Peoria, Illinois 61604, USA
    Mycologia 100:205-26. 2008
    ..460 Aspergillus isolates...
  5. ncbi Production and characterization of cellulolytic enzymes from the thermoacidophilic fungal Aspergillus terreus M11 under solid-state cultivation of corn stover
    Jianmin Gao
    Department of Bioengineering, Zhengzhou University, 100 Kexue Road, Zhengzhou 450001, PR China
    Bioresour Technol 99:7623-9. 2008
    The production of extracellular cellulases by a newly isolated thermoacidophilic fungus, Aspergillus terreus M11, on the lignocellulosic materials was studied in solid-state fermentation (SSF)...
  6. ncbi Apyap1 affects aflatoxin biosynthesis during Aspergillus parasiticus growth in maize seeds
    M Reverberi
    Universita degli Studi La Sapienza, 00165 Rome, Italy
    Food Addit Contam 24:1070-5. 2007
    ..On the basis of the results, a hypothesis regarding strategies to control aflatoxin synthesis is formulated...
  7. pmc Potential basis for amphotericin B resistance in Aspergillus terreus
    Gerhard Blum
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 52:1553-5. 2008
    This study investigated the basis for intrinsic amphotericin B (AMB) resistance in Aspergillus terreus. The ergosterol content, cell wall composition, and lipid peroxidation level had no influence on AMB resistance...
  8. pmc CADRE: the Central Aspergillus Data REpository 2012
    Jane Mabey Gilsenan
    School of Translational Medicine, University of Manchester, Manchester M23 9LT, UK
    Nucleic Acids Res 40:D660-6. 2012
    The Central Aspergillus Data REpository (CADRE; http://www.cadre-genomes.org.uk) is a public resource for genomic data extracted from species of Aspergillus...
  9. ncbi Aspergillus niger contains the cryptic phylogenetic species A. awamori
    Giancarlo Perrone
    Institute of Sciences of Food Production ISPA, National Research Council CNR, Via G Amendola 122 o, 70126 Bari, Italy
    Fungal Biol 115:1138-50. 2011
    b>Aspergillus section Nigri is an important group of species for food and medical mycology, and biotechnology...
  10. ncbi Developing Aspergillus as a host for heterologous expression
    David Lubertozzi
    Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
    Biotechnol Adv 27:53-75. 2009
    ..b>Aspergillus is an important genus, including well known species of economically significant molds, and widely used for ..
  11. ncbi Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis
    Monique A S H Mennink-Kersten
    Department of Medical Microbiology, University Medical Center St Radboud, Nijimegen, The Netherlands
    Lancet Infect Dis 4:349-57. 2004
    The availability of the Platelia Aspergillus, a sandwich ELISA kit that detects circulating galactomannan, has been a major advance for managing patients at risk for invasive aspergillosis because of the early detection of the antigen...
  12. ncbi Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species
    Eugénia Pinto
    Department of Microbiology CEQOFFUP CEQUIMED, Faculty of Pharmacy, University of Porto, 4050 047 Porto, Portugal
    J Med Microbiol 58:1454-62. 2009
    ..used to evaluate the antifungal activity of the clove oil and its main component, eugenol, against Candida, Aspergillus and dermatophyte clinical and American Type Culture Collection strains...
  13. ncbi Inhibitory effects of Satureja hortensis L. essential oil on growth and aflatoxin production by Aspergillus parasiticus
    Mehdi Razzaghi-Abyaneh
    Department of Mycology, Pasteur Institute of Iran, Tehran 13164, Iran
    Int J Food Microbiol 123:228-33. 2008
    ..was found as a potent inhibitor of aflatoxins B1 (AFB1) and G1(AFG1) production by Aspergillus parasiticus NRRL 2999. Fungal growth was also inhibited in a dose-dependent manner...
  14. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1...
  15. ncbi Purification and characterization of a novel endo-beta-1,4-glucanase from the thermoacidophilic Aspergillus terreus
    Jianmin Gao
    Department of Bioengineering, Zhengzhou University, 100 Kexue Road, Zhengzhou 450001, PR China
    Biotechnol Lett 30:323-7. 2008
    An endo-beta-1,4-glucanase from a thermoacidophilic fungus, Aspergillus terreus M11, was purified 18-fold with 14% yield and a specific activity of 67 U mg(-1) protein. The optimal pH was 2 and the cellulase was stable from pH 2 to 5...
  16. ncbi Transformation of Aspergillus sp. and Trichoderma reesei using the pyrithiamine resistance gene (ptrA) of Aspergillus oryzae
    Takafumi Kubodera
    Research and Development Department, Hakutsuru Sake Brewing Co Ltd, Kobe, Japan
    Biosci Biotechnol Biochem 66:404-6. 2002
    A pyrithiamine (PT) resistance gene (ptrA) was cloned from a PT resistant mutant of Aspergillus oryzae and was useful as a dominant selectable marker for transformation of all A. oryzae wild type strain as well as A. nidulans...
  17. pmc The Aspergillus Genome Database (AspGD): recent developments in comprehensive multispecies curation, comparative genomics and community resources
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 40:D653-9. 2012
    The Aspergillus Genome Database (AspGD; http://www.aspgd.org) is a freely available, web-based resource for researchers studying fungi of the genus Aspergillus, which includes organisms of clinical, agricultural and industrial importance...
  18. ncbi Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi
    Lei Ying Zhang
    MOE Key Laboratory for Biodiversity Sciences and Ecological Engineering, College of Life Sciences, Beijing Normal University, Beijing, 100875, China
    J Mol Evol 71:364-73. 2010
    Although intron loss and gain have been widely observed, their mechanisms are still to be determined. In four Aspergillus genomes, we found 204 cases of intron loss and 84 cases of intron gain...
  19. ncbi What is a species in Aspergillus?
    R A Samson
    CBS Fungal Biodiversity Centre, Utrecht, The Netherlands
    Med Mycol 47:S13-20. 2009
    The various species concepts with emphasis on those which can be applied to Aspergillus and its teleomorphs are discussed...
  20. ncbi A fungal sexual revolution: Aspergillus and Penicillium show the way
    Paul S Dyer
    School of Biology, University Park, University of Nottingham, Nottingham, NG7 2RD, UK
    Curr Opin Microbiol 14:649-54. 2011
    ..Using experimental and genomic findings from Aspergillus and Penicillium species as examples, it is argued that evidence such as the presence and expression of ..
  21. pmc New resources for functional analysis of omics data for the genus Aspergillus
    Benjamin M Nitsche
    Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
    BMC Genomics 12:486. 2011
    ..The genus Aspergillus comprises fungal species that are important model organisms, plant and human pathogens as well as industrial ..
  22. ncbi Sexual development and cryptic sexuality in fungi: insights from Aspergillus species
    Paul S Dyer
    School of Biology, University of Nottingham, Nottingham, UK
    FEMS Microbiol Rev 36:165-92. 2012
    ..sexual development and cryptic sexuality within filamentous fungi have been gained from investigations using Aspergillus species...
  23. ncbi Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48
    Hao Fen Sun
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People s Republic of China
    J Nat Prod 75:148-52. 2012
    Bioassay-guided fractionation of the culture extract of Aspergillus wentii EN-48, an endophytic fungus isolated from an unidentified marine brown algal species of the genus Sargassum, led to the isolation of three new tetranorlabdane ..
  24. ncbi Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 191:1188-95. 2005
    ..Studies of drug efficacy against IA and Aspergillus virulence rely on conventional animal models that are laborious and use limited numbers of animals; alternative,..
  25. ncbi The pathology of pulmonary disorders due to Aspergillus spp
    Richard L Kradin
    Department of Pathology, Warren 253, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 132:606-14. 2008
    Diagnosing the range of pulmonary disorders caused by Aspergillus spp can be challenging...
  26. pmc A key role for vesicles in fungal secondary metabolism
    Anindya Chanda
    Department of Food Science and Human Nutrition, National Food Safety and Toxicology Center, and Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824
    Proc Natl Acad Sci U S A 106:19533-8. 2009
    ..In this study we show that the filamentous fungus Aspergillus parasiticus employs this delivery system to perform new cellular functions, the synthesis, compartmentalization,..
  27. ncbi Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Curr Drug Targets 6:875-86. 2005
    ..Species of the Aspergillus family account for most of these infections and in particular Aspergillus fumigatus can be regarded as the most ..
  28. pmc veA is required for toxin and sclerotial production in Aspergillus parasiticus
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Appl Environ Microbiol 70:4733-9. 2004
    It was long been noted that secondary metabolism is associated with fungal development. In Aspergillus nidulans, conidiation and mycotoxin production are linked by a G protein signaling pathway. Also in A...
  29. ncbi Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis
    Carlo Mengoli
    Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, Padua, Italy
    Lancet Infect Dis 9:89-96. 2009
    ..Efforts are underway to devise a standard for Aspergillus sp PCR for screening, which will help enable formal validation of PCR and estimate its use in patients most ..
  30. ncbi StuA is required for cell pattern formation in Aspergillus
    K Y Miller
    Department of Bacteriology and Biochemistry, University of Idaho, Moscow 83843
    Genes Dev 6:1770-82. 1992
    ..stuA) gene product is required for the orderly differentiation and spatial organization of cell types of the Aspergillus nidulans conidiophore. Expression of the stuA gene is complex...
  31. pmc Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Prasanna D Khot
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Infect Dis 8:73. 2008
    ..Detection of Aspergillus DNA in BAL fluid by quantitative PCR (qPCR) offers the potential for earlier diagnosis and higher sensitivity...
  32. ncbi Expression and export: recombinant protein production systems for Aspergillus
    André Fleissner
    Institute of Genetics, Technische Universitat Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Appl Microbiol Biotechnol 87:1255-70. 2010
    Several Aspergillus species, in particular Aspergillus niger and Aspergillus oryzae, are widely used as protein production hosts in various biotechnological applications...
  33. pmc Colorimetric assay for antifungal susceptibility testing of Aspergillus species
    J Meletiadis
    Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Microbiol 39:3402-8. 2001
    A colorimetric assay for antifungal susceptibility testing of Aspergillus species (Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Aspergillus nidulans, and Aspergillus ustus) is described based on the reduction of the ..
  34. ncbi Allergic bronchopulmonary aspergillosis
    Paul A Greenberger
    Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 110:685-92. 2002
    Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and cystic fibrosis. The survival factors in Aspergillus fumigatus that support saprophytic growth in bronchial mucus are not understood...
  35. pmc Wild-type MIC distributions and epidemiological cutoff values for caspofungin and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)
    A Espinel-Ingroff
    VCU Medical Center, 3804 Dover Rd, Richmond, VA 23221, USA
    Antimicrob Agents Chemother 55:2855-9. 2011
    ..Epidemiologic cutoff values (ECVs) are available for six Aspergillus spp. and the triazoles, but not for caspofungin...
  36. ncbi Genetic re-identification and antifungal susceptibility testing of Aspergillus section Nigri strains of the BCCM/IHEM collection
    M Hendrickx
    Department of Mycology and Aerobiology, Scientific Institute of Public Health, Brussels, Belgium
    Mycoses 55:148-55. 2012
    ..In this study we (re-) identified 123 strains of the Aspergillus niger group of the BCCM/IHEM collection to check for the presence of species other than A...
  37. ncbi Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples
    Mona Syhre
    Otago University, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Med Mycol 46:209-15. 2008
    ..Our results confirm that 2PF is consistently produced by Aspergillus fumigatus, Fusarium spp., Aspergillus terreus, Aspergillus flavus and to a lesser extent by Aspergillus niger...
  38. ncbi Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer
    Gail Woods
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cancer 110:830-4. 2007
    ..Galactomannan is an Aspergillus-specific antigen released during invasive aspergillosis and is detected by the quantitative serum galactomannan ..
  39. ncbi Identification and analysis of Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae
    Tadashi Takahashi
    Noda Institute for Scientific Research, Noda City, Chiba, Japan
    Biosci Biotechnol Biochem 70:135-43. 2006
    ..We have identified Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae, and have constructed the disruption mutants of Ku70, Ku80, and Ku70-80 to ..
  40. pmc Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocystin in carpet dust from damp indoor environments
    Steffen Engelhart
    Institute of Hygiene and Public Health, University of Bonn, Bonn, Germany
    Appl Environ Microbiol 68:3886-90. 2002
    ..The goal of our pilot study was to quantify the proportion of toxigenic Aspergillus versicolor isolates in native carpet dust from damp dwellings with mold problems and to determine whether ..
  41. ncbi Aspergillus uvarum sp. nov., an uniseriate black Aspergillus species isolated from grapes in Europe
    Giancarlo Perrone
    Institute of Sciences of Food Production, CNR, via Amendola 122 O, 70126 Bari, Italy
    Int J Syst Evol Microbiol 58:1032-9. 2008
    A novel species, Aspergillus uvarum sp. nov., is described within Aspergillus section Nigri...
  42. ncbi Interstrain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-deficient Drosophila fly model of invasive aspergillosis
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Med Mycol 48:310-7. 2010
    Members of the genus Aspergillus are opportunistic fungal pathogens characterized by their genomic diversity...
  43. ncbi Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus
    Mitsuyasu Okabe
    Musashino Chemical Laboratory, Ltd, Yaesu Daibiru Bldg, 1 1 1 Kyobashi, Chuo Ku, Tokyo, 104 0031, Japan
    Appl Microbiol Biotechnol 84:597-606. 2009
    ....
  44. ncbi Assessment of a real-time PCR method to detect human non-cryptococcal fungal meningitis
    Parisa Badiee
    Prof Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    Arch Iran Med 14:381-4. 2011
    ..In this study, we investigate whether Aspergillus or Candida DNA can be detected in cerebrospinal fluid (CSF) samples from patients suspected of fungal ..
  45. pmc Wild-type MIC distributions and epidemiological cutoff values for amphotericin B and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)
    A Espinel-Ingroff
    VCU Medical Center, Richmond, Virginia, USA
    Antimicrob Agents Chemother 55:5150-4. 2011
    ..breakpoints have not been established for mold testing, epidemiological cutoff values (ECVs) are available for Aspergillus spp. versus the triazoles and caspofungin...
  46. ncbi Construction of a recombinant Trichoderma reesei strain expressing Aspergillus aculeatus β-glucosidase 1 for efficient biomass conversion
    Hikaru Nakazawa
    Department of Bioengineering, Nagaoka University of Technology, 1603 1 Kamitomioka, Nagaoka 940 2188, Japan
    Biotechnol Bioeng 109:92-9. 2012
    ..reesei strain, X3AB1, was constructed that expressed an Aspergillus aculeatus β-glucosidase 1 with high specific activity under the control of the xyn3 promoter...
  47. ncbi Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function
    J H Kim
    Plant Mycotoxin Research Unit, Western Regional Research Center, USDA ARS, Albany, CA 94710, USA
    J Appl Microbiol 101:181-9. 2006
    ..was to show whether antioxidative response systems are potentially useful molecular targets for control of Aspergillus fumigatus and Aspergillus flavus...
  48. pmc Draft genome sequencing and comparative analysis of Aspergillus sojae NBRC4239
    Atsushi Sato
    Research and Development Division, Kikkoman Corporation, 399 Noda, Noda City, Chiba 278 0037, Japan
    DNA Res 18:165-76. 2011
    We conducted genome sequencing of the filamentous fungus Aspergillus sojae NBRC4239 isolated from the koji used to prepare Japanese soy sauce...
  49. ncbi Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp
    Chang Lun Shao
    Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    Bioorg Med Chem Lett 21:690-3. 2011
    ..methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea...
  50. ncbi Aspergillus and Penicillium allergens: focus on proteases
    Horng Der Shen
    Department of Medical Research and Education, Taipei Veterans General Hospital, Shih Pai, Taipei, 11217, Taiwan
    Curr Allergy Asthma Rep 7:351-6. 2007
    Penicillium and Aspergillus species are prevalent airborne fungi. It is imperative to identify and characterize their major allergens...
  51. ncbi The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster
    Michael S Price
    North Carolina State University, Center for Integrated Fungal Research and Department of Plant Pathology, Raleigh, NC, USA
    FEMS Microbiol Lett 255:275-9. 2006
    ..Transcription profiling comparing wild type and DeltaaflR strains of Aspergillus parasiticus grown under conditions conducive for aflatoxin production identified only 23 upregulated genes in ..
  52. ncbi False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics
    Viboon Boonsarngsuk
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Scand J Infect Dis 42:461-8. 2010
    ..In summary, this study demonstrates the false-positive GM levels in serum and BAL caused by beta-lactam antibiotics that are commonly used in general practice. Physicians should be aware of this possible interference...
  53. ncbi Biodiesel production from isolated oleaginous fungi Aspergillus sp. using corncob waste liquor as a substrate
    G Venkata Subhash
    Bioengineering and Environmental Centre BEEC, Indian Institute of Chemical Technology IICT, Hyderabad 500607, India
    Bioresour Technol 102:9286-90. 2011
    The study documented the potential of isolated filamentous fungus Aspergillus sp. as whole cell biocatalyst for biodiesel production using Sabourauds dextrose broth medium (SDBM) and corncob waste liquor (CWL) as substrates...
  54. pmc Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid
    Perng Kuang Chang
    Southern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, 1100 Robert E Lee Boulevard, New Orleans, LA 70124, USA
    Toxins (Basel) 3:82-104. 2011
    Production of the harmful carcinogenic aflatoxins by Aspergillus parasiticus and Aspergillus flavus has been postulated to be a mechanism to relieve oxidative stress. The msnA gene of A. parasiticus and A...
  55. pmc DNA sequence characterization and molecular evolution of MAT1 and MAT2 mating-type loci of the self-compatible ascomycete mold Neosartorya fischeri
    C Rydholm
    Biology Department, Box 90338, Duke University, Durham, NC 27708, USA
    Eukaryot Cell 6:868-74. 2007
    ..self-fertile) euascomycete fungus Neosartorya fischeri, a close relative of the opportunistic human pathogen Aspergillus fumigatus...
  56. pmc Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51 06122 Perugia, Italy
    Blood 106:4397-406. 2005
    b>Aspergillus and cytomegalovirus are major causes of morbidity/mortality after haploidentical hematopoietic transplantation...
  57. pmc Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study
    Livio Pagano
    M D Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Largo Francesco Vito, 1 I 00168 Roma, Italia
    Haematologica 95:644-50. 2010
    ..The aim of this study was to evaluate prognostic factors, treatments and outcome of invasive aspergillosis in patients with acute myeloid leukemia based on data collected in a registry...
  58. pmc Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene
    Massimo Reverberi
    Dipartimento di Biologia Vegetale, Universita La Sapienza, Largo Cristina di Svezia 24, 00165 Roma, Italy
    Eukaryot Cell 7:988-1000. 2008
    ..levels of reactive oxygen species (ROS) were correlated with increased levels of aflatoxin biosynthesis in Aspergillus parasiticus...
  59. ncbi Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species
    Eugénia Pinto
    Department of Microbiology CEQOFF, Faculty of Pharmacy, University of Porto, 4050 Porto, Portugal
    J Med Microbiol 55:1367-73. 2006
    The composition of the essential oil of Thymus pulegioides and its antifungal activity on Candida, Aspergillus and dermatophyte fungal strains were studied...
  60. pmc Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Eukaryot Cell 4:625-32. 2005
    In a prior study, we identified seven clinical isolates of an Aspergillus sp...
  61. ncbi The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis
    J R Perfect
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 33:1824-33. 2001
    ..In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases...
  62. ncbi Isolation of epiphytic yeasts with potential for biocontrol of Aspergillus carbonarius and A. niger on grape
    Gianluca Bleve
    Institute of Sciences of Food Production ISPA, Lecce Section, CNR, Via provinciale Lecce Monteroni, 73100 Lecce, Italy
    Int J Food Microbiol 108:204-9. 2006
    ..isolates were tested in a preliminary screening on agar to select isolates showing a killer activity against Aspergillus carbonarius and A. niger, the main species responsible for the accumulation of ochratoxin A in grape...
  63. pmc Ochratoxin A production and amplified fragment length polymorphism analysis of Aspergillus carbonarius, Aspergillus tubingensis, and Aspergillus niger strains isolated from grapes in Italy
    Giancarlo Perrone
    Institute of Sciences of Food Production, ISPA CNR, Via G Amendola, 122 O, I 70126 Bari, Italy
    Appl Environ Microbiol 72:680-5. 2006
    ..The capabilities of species other than Aspergillus carbonarius within Aspergillus section Nigri to produce ochratoxin A from grapes are uncertain, since strain ..
  64. pmc Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus
    M A Pfaller
    Department of Pathology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 42:4419-31. 2004
  65. pmc Relationship between secondary metabolism and fungal development
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Microbiol Mol Biol Rev 66:447-59, table of contents. 2002
    ..In the case of the filamentous fungus Aspergillus nidulans, we review the only described work that genetically links the sporulation of this fungus to the ..
  66. ncbi Endogenous Aspergillus versicolor endophthalmitis in an immuno-competent HIV-positive patient
    Paolo Perri
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Mycopathologia 160:259-61. 2005
    ..Thus, a pars plana vitrectomy was performed. Aspergillus versicolor was isolated from the cultures of the vitreous sample and intravenous liposomal amphotericin B was ..
  67. pmc Aspergillus terreus accessory conidia are unique in surface architecture, cell wall composition and germination kinetics
    Eszter Deak
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS ONE 4:e7673. 2009
    Infection with Aspergillus terreus is more likely to result in invasive, disseminated disease when compared to other Aspergillus species; importantly this species appears to be less susceptible to the antifungal drug amphotericin B...
  68. ncbi Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary
    Gyöngyi Szigeti
    Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
    Mycopathologia 174:143-7. 2012
    ..Many fungal species have been identified as infectious agents in otomycosis, with Aspergillus and Candida species being the most common...
  69. ncbi Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction
    Richard A Wilson
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiology 150:2881-8. 2004
    In the mycotoxigenic oilseed pathogens Aspergillus flavus and Aspergillus parasiticus and the model filamentous fungus Aspergillus nidulans, unsaturated fatty acids and their derivatives act as important developmental signals that affect ..
  70. ncbi Production of mycotoxins by Aspergillus lentulus and other medically important and closely related species in section Fumigati
    Thomas O Larsen
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Kgs Lyngby, Denmark
    Med Mycol 45:225-32. 2007
    The production of mycotoxins and other secondary metabolites have been studied by LC-DAD-MS from six species in Aspergillus section Fumigati. This includes the three new species Aspergillus lentulus, A. novofumigatus and A...
  71. pmc Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center
    Russell E Lewis
    University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St 423, Houston, TX 77030, USA
    J Clin Microbiol 43:6120-2. 2005
    b>Aspergillus isolates (n = 103) collected from cancer patients were screened to determine the taxonomic distribution and quantity of gliotoxin production. Gliotoxin was detected in 93% of Aspergillus fumigatus, 75% of A. niger, 25% of A...
  72. ncbi Health effects of Aspergillus in food and air
    Maren A Klich
    USDA, ARS, Southern Regional Research Center, New Orleans, LA 70124, USA
    Toxicol Ind Health 25:657-67. 2009
    This review summarizes the health aspects of the medically important fungal genus Aspergillus. The morphology and systematics of the genus are explained as well as its biogeography...
  73. pmc Comparison of the real-time nucleic acid sequence-based amplification (RTi-NASBA) with conventional NASBA, and galactomannan assay for the diagnosis of invasive aspergillosis
    Jin Hong Yoo
    Department of Internal Medicine, Holy Family Hospital, Sosa 2 dong, Wonmi gu, Bucheon 420 717, Korea
    J Korean Med Sci 22:672-6. 2007
    ..45) was poor. When we use the combination of GM with either of two NASBAs, the sensitivity was improved up to 100%. In conclusion, RTi-NASBA could be a good alternative to the conventional one for the screening of IA...
  74. ncbi Secondary metabolites from Eurotium species, Aspergillus calidoustus and A. insuetus common in Canadian homes with a review of their chemistry and biological activities
    Gregory J Slack
    Ottawa Carleton Institute of Chemistry, Carleton University, Ottawa, ON K1S5B6, Canada
    Mycol Res 113:480-90. 2009
    ..herbariorum, E. amstelodami, and E. rubrum as well as a number of isolates provisionally identified as Aspergillus ustus. The latter have been recently assigned as the new species A. insuetus and A. calidoustus. E...
  75. ncbi Pathogen-induced production of the antifungal AFP protein from Aspergillus giganteus confers resistance to the blast fungus Magnaporthe grisea in transgenic rice
    Ana Beatriz Moreno
    Departamento de Genetica Molecular, Instituto de Biologia Molecular de Barcelona, CSIC Jordi Girona 18, 08034 Barcelona, Spain
    Mol Plant Microbe Interact 18:960-72. 2005
    ..grisea whereby pathogen-induced expression of the afp (antifungal protein) gene from Aspergillus giganteus occurs in transgenic rice plants...
  76. pmc Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes
    Ludmila V Roze
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA
    Fungal Genet Biol 48:35-48. 2011
    ..Filamentous fungi in the genus Aspergillus synthesize an array of secondary metabolites and provide useful systems to analyze the mechanisms that mediate ..
  77. pmc Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism
    Ludmila V Roze
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA
    BMC Biochem 11:33. 2010
    Filamentous fungi in the genus Aspergillus produce a variety of natural products, including aflatoxin, the most potent naturally occurring carcinogen known...
  78. ncbi Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 191:1350-60. 2005
    ..Anecdotal evidence suggests a rise in zygomycosis in association with voriconazole (VRC) use in immunosuppressed patients...
  79. ncbi Aspergillus terreus: an emerging amphotericin B-resistant opportunistic mold in patients with hematologic malignancies
    Ray Y Hachem
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer 101:1594-600. 2004
    ..At The University of Texas M. D. Anderson Cancer Center (Houston, TX), Aspergillus terreus is second to A. fumigatus as the most common cause of IA...
  80. ncbi Strain improvement for tannase production from co-culture of Aspergillus foetidus and Rhizopus oryzae
    Jogeswar Satchidananda Purohit
    Microbial Biotechnology and Downstream Processing Laboratory, Department of Agricultural and Food Engineering, Indian Institute of Technology, Kharagpur 721 302, India
    Bioresour Technol 97:795-801. 2006
    Spores from the co-culture of Aspergillus foetidus and Rhizopus oryzae were subjected to UV, heat and NTG (3-nitro,5-methylguanidine) mutagenesis. A few colonies were screened from the selected media for tannase study...
  81. ncbi Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay
    Kieren A Marr
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Infect Dis 40:1762-9. 2005
    ..Reported sensitivity of the galactomannan enzyme immunoassay as an early diagnostic test for invasive aspergillosis (IA) has been widely variable, ranging from 29% to 100% in earlier clinical studies...
  82. ncbi Three novel, structurally unique spirocyclic alkaloids from the halotolerant B-17 fungal strain of Aspergillus variecolor
    Wen Liang Wang
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China
    Chem Biodivers 4:2913-9. 2007
    ..novel alkaloids, variecolortides A-C (1-3), were isolated from the mycelia of the halotolerant fungal strain Aspergillus variecolor B-17...
  83. ncbi Sexual reproduction and recombination in the aflatoxin-producing fungus Aspergillus parasiticus
    Bruce W Horn
    National Peanut Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Dawson, GA 39842, USA
    Fungal Genet Biol 46:169-75. 2009
    ..One such asexual species, Aspergillus parasiticus, is a potent producer of carcinogenic and hepatotoxic aflatoxins, polyketide-derived secondary ..
  84. ncbi Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1
    Jinkai Zheng
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    Org Lett 11:5262-5. 2009
    ..and dehydroamino acid units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorum PT06-1 in a nutrient-limited hypersaline medium...
  85. ncbi Isolated invasive Aspergillus tracheobronchitis: a clinical study of 19 cases
    N Wu
    Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China
    Clin Microbiol Infect 16:689-95. 2010
    Isolated invasive Aspergillus tracheobronchitis (iIATB) is an uncommon clinical form of invasive Aspergillosis in which Aspergillus infection is limited entirely or predominantly to the tracheobronchial tree...
  86. pmc Aspergillus PCR: one step closer to standardization
    P Lewis White
    NPHS Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Clin Microbiol 48:1231-40. 2010
    ..In 2006, the European Aspergillus PCR Initiative was formed...
  87. ncbi Tannase production by Aspergillus aculeatus DBF9 through solid-state fermentation
    D Banerjee
    Department of Microbiology, Vidyasagar University, Midnapore 721 102, West Bengal, India
    Acta Microbiol Immunol Hung 54:159-66. 2007
    Tannase an industrially important enzyme was produced by Aspergillus aculeatus DBF9 through a solid-state fermentation (SSF). The organism produced good amount of enzyme and gallic acid in wheat bran among the solid substrate used in SSF...
  88. ncbi Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor
    Wen Liang Wang
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    J Nat Prod 70:1558-64. 2007
    ..1- 12), together with eleven known analogues ( 13- 23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compounds 1- 12 were determined by chemical and spectroscopic methods...
  89. ncbi Trends in invasive fungal infections, with emphasis on invasive aspergillosis
    Z Erjavec
    Department of Internal Medicine, Ommelander Groep Delfzicht Hospital, Delfzijl, The Netherlands
    Clin Microbiol Infect 15:625-33. 2009
    ..Although yeast infections appear to have reached a stable incidence, the number of infections as a result of Aspergillus species appears to be increasing...
  90. pmc Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus
    Christina Grosse
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University Jena, 07745 Jena, Germany
    Appl Environ Microbiol 74:4923-33. 2008
    b>Aspergillus fumigatus is an opportunistic human pathogenic fungus causing severe infections in immunocompromised patients. Cyclic AMP (cAMP) signal transduction plays an important role in virulence...
  91. ncbi Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1
    Jinkai Zheng
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    J Nat Prod 73:1133-7. 2010
    ..and penicillic acid, were isolated from the ethyl acetate extract of the fermentation broth of the halotolerant Aspergillus sclerotiorum PT06-1 in a hypersaline nutrient-rich medium...
  92. ncbi Discrimination of Aspergillus isolates at the species and strain level by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry fingerprinting
    Justin M Hettick
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Anal Biochem 380:276-81. 2008
    ..MS) was used to generate highly reproducible mass spectral fingerprints for 12 species of fungi of the genus Aspergillus and 5 different strains of Aspergillus flavus...
  93. ncbi Pseudomembranous and obstructive Aspergillus tracheobronchitis - optimal diagnostic strategy and outcome
    Selcuk Tasci
    Department of Internal Medicine II, University of Bonn, Germany
    Mycoses 49:37-42. 2006
    Pseudomembranous and obstructive Aspergillus tracheobronchitis (PMATB/OATB) are still considered to be refractory to therapy and to have a fatal outcome...
  94. pmc Innate immunity to Aspergillus species
    Stacy J Park
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, P O Box 800546, Charlottesville, VA 22908, USA
    Clin Microbiol Rev 22:535-51. 2009
    All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear the organism without developing disease and without the development of antibody- or cell-mediated acquired immunity to this organism...
  95. ncbi Isolation of genes encoding novel transcription factors which interact with the Hap complex from Aspergillus species
    Akimitsu Tanaka
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Biochim Biophys Acta 1576:176-82. 2002
    ..Although homologues of Hap2/3/5p (in the case of Aspergillus nidulans; HapB/C/E, respectively) were found in many eukaryotes, no Hap4p homologues have been found except for ..
  96. ncbi Cloning and characterization of two structurally and functionally divergent rhamnogalacturonases from Aspergillus aculeatus
    L V Kofod
    GeneExpress, Novo Nordisk A S, BioIndustrial Group, Copenhagen, Denmark
    J Biol Chem 269:29182-9. 1994
    Two rhamnogalacturonases from the filamentous fungus Aspergillus aculeatus have been cloned and characterized. A cDNA library from A...
  97. ncbi Repressor-AFLR interaction modulates aflatoxin biosynthesis in Aspergillus parasiticus
    P K Chang
    Southern Regional Research Center, U S Department of Agriculture, New Orleans, Louisiana 70124, USA
    Mycopathologia 147:105-12. 1999
    ..if the AFLR carboxyl region (AFLRC) interacts with positive- or negative-acting proteins, we fused the Aspergillus parasiticus aflR carboxyl coding region (aflRC) to the promoter of A...
  98. ncbi Late onset of invasive aspergillus infection in bone marrow transplant patients at a university hospital
    W B Grow
    University of Florida College of Medicine, Shands Hospital, Gainesville, FL 32610 0277, USA
    Bone Marrow Transplant 29:15-9. 2002
    ..These data have important implications in an era of alternate donor transplants and more intense immunosuppression. Established strategies implementing newer, less toxic antifungal agents as prophylaxis in high-risk patients are needed...
  99. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
    ..Infections with non-fumigatus Aspergillus species, Fusarium species, and Zygomycetes increased during the late 1990s, especially in patients who received ..
  100. pmc Variability of germinative potential among pathogenic species of Aspergillus
    Ricardo Araujo
    Department of Microbiology, Faculty of Medicine, and IPATIMUP, University of Porto, 4200 319 Porto, Portugal
    J Clin Microbiol 42:4335-7. 2004
    The objective of our study was to evaluate parameters influencing the germination of Aspergillus conidia. Inoculum concentration and age significantly influenced germination...
  101. ncbi Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida
    Peter A Warn
    School of Medicine, University of Manchester, Hope Hospital, Salford M6 8HD
    J Antimicrob Chemother 53:743-9. 2004
    The aim of this study was to investigate the effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus (four species) and Candida (six species).

Research Grants78

  1. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..Aflatoxins are mycotoxins produced by the common fungal molds, Aspergillus flavus and Aspergillus parasiticus...
  2. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..Aflatoxins are produced by the fungi Aspergillus, which can contaminate corn, wheat, soy beans, sorghum, peanuts, almonds, and milk. They affect 4...
  3. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..have access to Candida albicans that has been genetically engineered to express Gaussia princeps luciferase and Aspergillus fumigates expressing firefly luciferase that form localized infections that can be imaged by bioluminescence ..
  4. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..coli flavohemoglobin and a series of fungal (Candida albicans and Aspergillus fumigatus) flavohemoglobins, which catalyze this reaction as part of a defense mechanism against host-induced ..
  5. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..The most common causative agent of IA is Aspergillus fumigatus, a mold frequently present in the environment...
  6. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..pathway affect fungal pathogenesis not only of fungi infecting humans, such as Cn3, 4, Candida albicans5-7, and Aspergillus fumigatus8, but also of fungi infecting plants, such as Fusarium graminearum9...
  7. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is associated with mortality rates of 40- 50%...
  8. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..The goal of this project is development of an immunoassay for detection of Aspergillus antigens in blood or urine to facilitate early diagnosis of IA...
  9. Identification and Analysis of Circadian Clock-Controlled Genes
    Jennifer J Loros; Fiscal Year: 2013
    ..We will extend analysis of photobiology to the important fungal pathogen Aspergillus fumigatus where we can envision a way to exploit our understanding of fungal photobiology to enable a new ..
  10. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    ..The poor efficacy of antifungal drugs against IA may be linked to the propensity of Aspergillus species to invade pulmonary blood vessels, causing intravascular thrombosis, tissue ischemia and infarction...
  11. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    ..to a broad spectrum of keratitis causing pathogens, including Pseudomonas aeruginosa, Candida albicans and Aspergillus fumigates...
  12. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..and the beta-glucan receptor Dectin-1 in the development of allergy or tolerance to the ubiquitous fungus Aspergillus fumigatus...
  13. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    Infections caused by Aspergillus fumigatus are a leading cause of death in immune compromised individuals. A...
  14. Novel antifungals for Immunocompromised/HIV patients.
    ESTEBAN EDWARD MENA; Fiscal Year: 2011
    ..against both fluconazole sensitive (ATCC 90028) and resistant Candida strains ATCC 90030, 96901, 6852) and Aspergillus fumigatus and Cryptococcus neoformans...
  15. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The respiratory immune system clears hundreds of airborne Aspergillus fumigatus spores (conidia) daily...
  16. Immune Dysregulation in Uremia
    Neal B Blatt; Fiscal Year: 2013
    ..the third specific aim, the immune systems of SNx and control mice will be challenged in vivo with the fungus Aspergillus fumigatus, which will serve as a model organism to probe pro-inflammatory immune responses that depend upon the ..
  17. Heterogeneity among human CD4 T lymphocytes
    Dale T Umetsu; Fiscal Year: 2010
    ..contain previously unappreciated microbes, which could activate NKT cells, and that glycolipids purified from Aspergillus can specifically activate NKT cells...
  18. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is the major filamentous fungal pathogen in humans...
  19. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is the most common cause of invasive mold infections. Even with advances in therapy and early diagnostics, mortality rates remain high...
  20. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2013
    ABSTRACT With the rise in susceptible individuals, the burden of disease due to Aspergillus fumigatus has increased substantially...
  21. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..albicans or Aspergillus fumigatus...
  22. Mechanisms of Host Adaptation for Candida albicans
    PETER JOHN ESPENSHADE; Fiscal Year: 2013
    ..In fungal pathogens such as Cryptococcus neoformans and Aspergillus fumigatus, the membrane-bound sterol regulatory element binding protein (SREBP) is a key hypoxic transcription ..
  23. Expanding small molecule functional metagenomics through shuttle BAC expression i
    CHENGCANG CHARLES WU; Fiscal Year: 2011
    ..terreus, iii) the knowledge of global secondary metabolite cluster regulation in Aspergillus, iv) an engineered fungal host A...
  24. The Role of IL-17 in fungal keratitis
    PATRICIA RENEE TAYLOR; Fiscal Year: 2013
    ..In the current study, we examined the role of IL-17 in a murine model of Aspergillus and Fusarium infections of the cornea, which are a major cause of blindness and visual impairment worldwide...
  25. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT cells, resulting in innate and adaptive mucosal immune ..
  26. Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucin
    John V Fahy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pseudomonas and Aspergillus cause life threatening lung infections. Antibiotics to treat these infections are not always effective, and new treatment approaches are urgently needed...
  27. Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutases
    Pablo Sobrado; Fiscal Year: 2013
    ..Deletion of the UGM gene results in severely attenuated virulence of the fungal pathogen Aspergillus fumigatus and the protozoan parasite Leishmania major, suggesting UGM as a promising drug design target...
  28. Structural Requirements for Sterol 14alpha-Demethylases
    Galina I Lepesheva; Fiscal Year: 2013
    ..these scaffolds and their derivatives as potential drugs for treatment of infection by Candida albicans and Aspergillus (A) fumigatus and A. flavus...
  29. Identification of calcineurin-binding proteins in A. fumigatus septum formation
    William J Steinbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus has surpassed invasive candidiasis as the most frequent fungal cause of death in immunocompromised patients...
  30. Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
    Jatin M Vyas; Fiscal Year: 2013
    ..TLR signaling pathways remained intact 3) CD82 is recruited to phagosomes containing fungal pathogens including Aspergillus fumigatus as determined by time-lapse imaging of a fluorescentlytagged version of CD82 expressed in primary DCs ..
  31. Environmenal epigenitics and innate immunity
    John W Hollingsworth; Fiscal Year: 2012
    ..Diesel particle exposure in mice enhances the allergic airway response to Aspergillus fungus antigen through alteration of CpG methylation of key Th2 gene promoters...
  32. Functional Analysis and Systems Biology of Filamentous Fungi
    Jay C Dunlap; Fiscal Year: 2013
    ..we will leverage our prior successes to expand systematic knockouts to an additional prominent model system, Aspergillus nidulans...
  33. Novel Biomarkers for Early Detection of Aspergillosis
    Ram Ramabhadran; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients...
  34. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..microorganisms, including Streptococcus pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT cells, resulting in innate and adaptive mucosal immune ..
  35. Control of Aspergillus fumigatus polarized growth through regulation of Ras prote
    Jarrod Fortwendel; Fiscal Year: 2013
    ..b>Aspergillus fumigatus is a commonly isolated, opportunistic mould. The conidia of A...
  36. TAS::75 0862::TAS
    Martin D Chapman; Fiscal Year: 2010
    ..Multiplex Array for Mold Biomarkers (MAMB) on the xMAP system to measure allergens/antigens from Alternaria, Aspergillus fumigatus, A. versicolor, Stachybotrys and Penicillium spp...
  37. Aspergillus-specific CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2010
    b>Aspergillus fumigatus is a clinically important fungal pathogen that causes invasive disease in immunocompromised hosts...
  38. CD1d and NKT Cell Activation and Function in Infection
    Michael B Brenner; Fiscal Year: 2013
    ..We have found that several common fungal pathogens such as Candida albicans and Aspergillus fumigatus efficiently activate iNKT cells...
  39. Role of VeA-Dependent Genes and Proteins in Mycotoxin Production and Development
    Ana M Calvo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspergillus spp. mycotoxins infect corn, cotton, sorghum and nuts. Controlling mycotoxin biosynthesis or fungal development would decrease its devastating health and economic impact...
  40. The role of TLR9 on Aspergillus fumigatus phagosomes
    Jatin M Vyas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is a saprophytic filamentous fungus whose asexual spores called conidia are widespread in the environment, acquired through inhalation and small enough to reach the distal ..
  41. Mutational Analysis of Fks1: Intrinsic Echinocandin Resistance
    Thomas D Edlind; Fiscal Year: 2010
    ..Cryptococcus, Trichosporon, and zygomycete s~ies are characterized by high-level intrinsic RES, while Aspergillus specics and Candida parapsilosis exhibit low-level intrinsic RES...
  42. Transcriptional regulation of A. fumigatus virulence
    Scott G Filler; Fiscal Year: 2013
    ..A critical step in the pathogenesis o invasive aspergillosis is the interaction of Aspergillus fumigatus with pulmonary epithelial cells. After being inhaled, A...
  43. Innovative Assay Development for the Diagnosis of Invasive Aspergillosis
    Marc D Porter; Fiscal Year: 2012
    ..been assembled and includes immunologists with expertise in monoclonal antibody development and screening for Aspergillus spp;medical microbiologists with strengths in basic mycology, and in fungal assay development and validation;..
  44. The systems biology of iron homeostasis and the immune response to Aspergillus
    CHRISTOPHER BRIAN LAWRENCE; Fiscal Year: 2013
    ..by applicant): The specific aims of this project are designed to better understand the biology and virulence of Aspergillus fumigatus, the causative agent of invasive aspergillosis (IA), the host immune response, and the role of iron ..
  45. Biosynthesis of HSAF, an antifungal natural product with a novel mode of action
    Liangcheng Du; Fiscal Year: 2009
    ..potent activities against a wide range of fungal species, including the life-threatening human pathogen, Aspergillus fumigatus, and shows a novel mode of action by disrupting the polarized growth of filamentous fungi...
  46. Claudin-18 deficiency in the pathogenesis of asthma
    James A Frank; Fiscal Year: 2013
    ..permeability to environmental antigen and induce a more severe asthma phenotype in the mouse model of aspergillus sensitization...
  47. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive pulmonary aspergillosis caused by the mold Aspergillus fumigatus has emerged as one of the most severe invasive fungal infections, not only in an expanding population of immunosuppressed ..
  48. Myocotic Ulcer Treatment Trial
    Thomas M Lietman; Fiscal Year: 2013
    ..the newer triazoles are more effective than natamycin in vitro against filamentous fungi such as Fusarium and Aspergillus spp, the most common causes of fungal keratitis worldwide...
  49. Echinocandin Reduced/Increased Susceptibility: Mechanism
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..analysis/DNA sequencing implicated sphingolipid pathway gene TSC13/tsc13 loss of heterozygosity;and (b) an Aspergillus nidulans basA(Sur2) mutant exhibited 2-fold CRS, 8-fold MIS...
  50. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Humans inhale ubiquitous Aspergillus fumigatus conidia on a daily basis...
  51. Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    William J Steinbach; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is a leading cause of death in immunocompromised patients. Current IA therapy has a disappointing treatment success rate...
  52. Dectin-1 and Invasive Pulmonary Aspergillosis
    Chad Steele; Fiscal Year: 2010
    ..results in a significant predisposition to invasive fungal infections, particularly those caused by Aspergillus fumigatus...
  53. The Pathogenesis of Aspergillus Keratitis
    SIXTO MANUEL LEAL; Fiscal Year: 2012
    ..During Aspergillus keratitis, the inflammation can be so severe that 42-60% of infections end with corneal transplantation...
  54. Maintenance of Lung Homeostasis by Integrin alphanubeta8
    ANDREW CHARLES MELTON; Fiscal Year: 2010
    ..responses of mice with a conditional deletion of av[unreadable]8 integrin on leukocytes in the ovalbumin- and Aspergillus-induced allergic asthma models...
  55. Control of Airway Tolerance
    Michael Croft; Fiscal Year: 2013
    ..allergens associated with asthma, from Dermatophagoides pteronyssinus, a house dust mite (HDM), and from Aspergillus fumigatus, a fungus...
  56. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
    ..These aims will utilize VPAC2 wild type (C57BL/6) and knockout mice in an inhalation model of Aspergillus fumigatus allergic asthma that was developed by our research team...
  57. High-density lipoprotein and A. fumigatus pathogenesis
    David S Askew; Fiscal Year: 2013
    ..and the defense against invasive aspergillosis (IA), a life-threatening infection caused by the mold pathogen Aspergillus fumigatus...
  58. Biosynthesis of Antifungal Lipopeptides from Filamentous Fungi
    Yi Tang; Fiscal Year: 2013
    ..We have recently identified the gene cluster from the producing organism Aspergillus nidulans sp...
  59. ER stress and virulence of Aspergillus fumigatus
    David S Askew; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is an important opportunistic fungal pathogen that has become the leading infectious mould of immunocompromised patients...
  60. Clinical and Molecular Phenotypes of Severe Asthma
    John V Fahy; Fiscal Year: 2013
    ..Included in the lectins we will study will be Aspergillus fumigatus lectin, a fucose binding lectin that we hypothesize to have a pathogenic role in the mechanism of ..
  61. Improving the Diagnosis of Histoplasmosis in an Endemic Region
    Kathleen R Page; Fiscal Year: 2011
    ..A prototype assay was successfully developed in our laboratory for the detection of Aspergillus antigens...
  62. Mining the Aspergillus nidulans Secondary Metabolome
    BERL RAY OAKLEY; Fiscal Year: 2012
    ..products chemistry to identify and purify potentially useful secondary metabolites of the filamentous fungus Aspergillus nidulans...
  63. The role of the NIMA kinase in mitotic regulation
    Stephen A Osmani; Fiscal Year: 2013
    ..We have shown the NIMA mitotic kinase of Aspergillus nidulans initiates mitosis by promoting NPC disassembly...
  64. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..For this purpose, Aspergillus fumigatus, a fungus that causes disease in patients with immunocompromised immune systems, has been selected as ..
  65. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Cryptococcus and the Zygomycoses...
  66. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ..The approach has been to study immune responses to two fungi: Aspergillus fumigatus that commonly grows in the respiratory tract, and dermatophytes of the genus Trichophyton that grow ..
  67. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    ..protease, but this has now been confirmed using recombinant lactoferrin expressed in baby hamster kidney cells, Aspergillus awamori, and baculovirus expression systems. Bovine milk lactoferrin has similar activity...
  68. ASPERGILLUS ELASTASE, A POTENTIAL VIRULENCE FACTOR
    JUDITH RHODES; Fiscal Year: 1990
    ..Invasive pulmonary aspergillosis is initiated by inhaling the air-borne conidia of the ubiquitous Aspergillus species...
  69. A NOVEL TARGET FOR THE DEVELOPMENT OF ANTIFUNGAL AGENTS
    Corey Nislow; Fiscal Year: 2001
    ..in opportunistic fungal infections such as candidiasis, zygomycosis, cryptococcosis, histoplasmosis, and Aspergillus and Fusarium infections in immunocompromised individuals, including AIDS patients, the elderly, surgical ..
  70. Remediation Process for Aflatoxin Contaminated Foods
    ADRIAN DENVIR; Fiscal Year: 2002
    Mycotoxins are carcinogenic compounds that are produced by Aspergillus, Penicillium and Fusarium molds on agricultural produce and affect up to 25 per cent of the worlds food crops...
  71. Functions, Traffic and Targeting of Fungal Adhesins
    SCOTT ERDMAN; Fiscal Year: 2003
    ..to the life cycles of many fungi pathogenic to humans including Candida species, Cryptococcus neoformans, Aspergillus fumigatus and Histoplasma capsulatum...
  72. NOVEL PROTEASE FORMULATION BASED ON CROSSLINKED CRYSTALS
    Bhami Shenoy; Fiscal Year: 2004
    ..In the Phase I grant, we developed a stable, active formulation of protease from Aspergillus melleus, TheraCLEC-Protease, for use in the treatment of chronic abdominal pain in chronic pancreatitis and ..
  73. PARACOCCIDIOIDOMYCOSIS--EVOLUTION AND STRAIN-TYPING
    John Taylor; Fiscal Year: 2002
    ..species concepts are morphological, but our experience with Histoplasma capsulatum, Coccidioides immitis and Aspergillus flavus shows that a morphological species can harbor more than one genetically isolated species...
  74. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    ..is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af). It results in marked lung damage in patients with bronchial asthma or cystic fibrosis (CF)...
  75. ASPERGILLUS FUMIGATUS COMPLEMENT INHIBITOR
    RONALD WASHBURN; Fiscal Year: 1991
    A complement inhibitor (CI) produced by Aspergillus fumigatus selectively inhibited the alternative pathway. This was the first observation of a CI produced by a fungus which causes human disease...
  76. GENOME SEQUENCING OF ASPERGILLUS FUMIGATUS
    David Denning; Fiscal Year: 2001
    b>Aspergillus fumigatus is the most common cause of life-threatening mold infection (aspergillosis). Its spores are found in the air everywhere and are therefore unavoidable...
  77. A molecular toolbox for hypothesis testing in the dermatophytes
    Theodore C White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dermatophytes are molds, closely related to Aspergillus and the dimorphic fungi...
  78. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...