reishi

Summary

Summary: A mushroom, Ganoderma lucidum, of the POLYPORALES order of basidiomycetous fungi. It has long been used in traditional Chinese medicine in various forms. Contains STEROLS; COUMARINS; MANNITOL; POLYSACCHARIDES; and triterpenoids.

Top Publications

  1. ncbi Ganoderma lucidum (Reishi) in cancer treatment
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 2:358-64. 2003
  2. ncbi Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro
    Chao Yang Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Vaccine 28:4945-54. 2010
  3. pmc The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]
    Dongbo Liu
    Hunan Agricultural University, Changsha, Hunan, China
    PLoS ONE 7:e36146. 2012
  4. ncbi Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 298:603-12. 2002
  5. ncbi Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum
    Chang Hua Shang
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Jiangsu, People s Republic of China
    Biosci Biotechnol Biochem 74:974-8. 2010
  6. ncbi Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center
    J Pharmacol Sci 99:144-53. 2005
  7. ncbi Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum
    Soniamol Joseph
    Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode Thiruvananthapuram 695562, India
    Acta Pharm 61:335-42. 2011
  8. ncbi Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 25:1387-95. 2004
  9. ncbi Current progress in the study on biosynthesis and regulation of ganoderic acids
    Liang Shi
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, No 1 Weigang, Nanjing, 210095 Jiangsu, People s Republic of China
    Appl Microbiol Biotechnol 88:1243-51. 2010
  10. ncbi A laccase from the medicinal mushroom Ganoderma lucidum
    H X Wang
    State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing 100094, China
    Appl Microbiol Biotechnol 72:508-13. 2006

Detail Information

Publications192 found, 100 shown here

  1. ncbi Ganoderma lucidum (Reishi) in cancer treatment
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 2:358-64. 2003
    The popular edible mushroom Ganoderma lucidum (Reishi) has been widely used for the general promotion of health and longevity in Asian countries...
  2. ncbi Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro
    Chao Yang Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Vaccine 28:4945-54. 2010
    ....
  3. pmc The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]
    Dongbo Liu
    Hunan Agricultural University, Changsha, Hunan, China
    PLoS ONE 7:e36146. 2012
    Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries...
  4. ncbi Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 298:603-12. 2002
    ..Our data suggest that spores and unpurified fruiting body of G. lucidum inhibit invasion of breast and prostate cancer cells by a common mechanism and could have potential therapeutic use for cancer treatment...
  5. ncbi Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum
    Chang Hua Shang
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Jiangsu, People s Republic of China
    Biosci Biotechnol Biochem 74:974-8. 2010
    ..lucidum during development. Up-regulation of expression of the Gl-LS gene by methyl jasmonate (MeJA) in the mycelia was also demonstrated by real-time RT-PCR. Up-regulation of the Gl-LS promoter activity by MeJA was also investigated...
  6. ncbi Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center
    J Pharmacol Sci 99:144-53. 2005
    Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi or Reishi) has been used for a long time in China to prevent and treat various human diseases. G. lucidum polysaccharides extracted from G...
  7. ncbi Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum
    Soniamol Joseph
    Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode Thiruvananthapuram 695562, India
    Acta Pharm 61:335-42. 2011
    ..At 100 mg kg(-1), GLP exhibited 57.6 and 58.2% inhibition in carrageenean-induced and formalin-induced assays, respectively...
  8. ncbi Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 25:1387-95. 2004
    ..Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum...
  9. ncbi Current progress in the study on biosynthesis and regulation of ganoderic acids
    Liang Shi
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, No 1 Weigang, Nanjing, 210095 Jiangsu, People s Republic of China
    Appl Microbiol Biotechnol 88:1243-51. 2010
    ..Moreover, this review focuses on suggesting new directions for studying GAs and attempts to gain some insights for better understanding of the biosynthesis and regulation of GAs...
  10. ncbi A laccase from the medicinal mushroom Ganoderma lucidum
    H X Wang
    State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing 100094, China
    Appl Microbiol Biotechnol 72:508-13. 2006
    ..The enzyme required a pH of 3-5 and a temperature of 70 degrees C to exhibit maximal activity. Minimal activity was detected at pH 6 and 7. Activity was undetectable at pH 8 and 9 and after exposure to 100 degrees C for 10 min...
  11. ncbi Ganoderma lucidum: a potent pharmacological macrofungus
    Bhagwan S Sanodiya
    Research and Development Centre, Bisen Biotech and Biopharma Pvt Ltd, Biotech Research Park, M 7, Laxmipuram, Transport Nagar, Gwalior 474010 M P India
    Curr Pharm Biotechnol 10:717-42. 2009
    ..Present review focuses on the pharmacological aspects, cultivation methods and bioactive metabolites playing a significant role in various therapeutic applications...
  12. ncbi Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities
    Yuan Yuan Wang
    Laboratory of Bioorganic Chemistry, Institute of Chemistry, Academia Sinica, Taipei, Taiwan
    Bioorg Med Chem 10:1057-62. 2002
    ....
  13. ncbi Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
    Shailesh Dudhgaonkar
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int Immunopharmacol 9:1272-80. 2009
    ..In conclusion, the anti-inflammatory and anti-proliferative effects of GLT on macrophages are mediated through the inhibition of NF-kappaB and AP-1 signaling pathways...
  14. ncbi Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 49:209-16. 2004
    Ganoderma lucidum (Reishi, Lingzhi) is a popular Asian mushroom that has been used for more than 2 millennia for the general promotion of health and was therefore called the "Mushroom of Immortality...
  15. ncbi Telomerase-associated apoptotic events by mushroom ganoderma lucidum on premalignant human urothelial cells
    John W M Yuen
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
    Nutr Cancer 60:109-19. 2008
    ..This study strongly suggests that G. lucidum is a potential source of chemopreventive agents for bladder cancer based on its effectiveness in controlling the premalignant urothelial cell growth and carcinogen-induced transformation...
  16. ncbi Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst occurring in South India
    T P Smina
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555, India
    Environ Toxicol Pharmacol 32:438-46. 2011
    ..The results showed that Ganoderma triterpenes did not possess significant toxicity. The findings thus reveal the possible therapeutic use of Ganoderma triterpenes...
  17. ncbi Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
    ..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
  18. ncbi Cloning and characterization of squalene synthase (SQS) gene from Ganoderma lucidum
    Ming Wen Zhao
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Nanjing 210095, Jiangsu, PR China
    J Microbiol Biotechnol 17:1106-12. 2007
    ..Functional complementation of Gl-SQS in a SQS-deficient strain of Saccharomyces cerevisiae confirmed that the cloned cDNA encoded a squalene synthase...
  19. ncbi Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin
    Sufen Zhao
    Department of Biology, York University, Toronto, Canada
    Int J Oncol 38:1319-27. 2011
    ..Taken together, these findings suggest that Ganoderma lucidum exerts multiple anti-tumor effects on ovarian cancer cells and can enhance the sensitivity of EOC cells to cisplatin...
  20. ncbi Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
    Xiao Ling Zhu
    Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China xiaolingzhu88yahoo com cn
    J Ethnopharmacol 111:219-26. 2007
    ....
  21. pmc Genome sequence of the model medicinal mushroom Ganoderma lucidum
    Shilin Chen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Nat Commun 3:913. 2012
    ..The elucidation of the G. lucidum genome makes this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi...
  22. ncbi Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds
    Jiri Adamec
    Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
    J Sep Sci 32:4052-8. 2009
    ..32 mg/g; GA F: 0.43 mg/g and GA H: 0.85 mg/g) extracts. The method was also used for the evaluation of bioavailability of triterpenes after an oral application and demonstrated the presence of G. lucidum triterpenes in plasma...
  23. ncbi Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway
    Ming Jen Hsu
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1 Sec 1, Jen Ai Road, Taipei, Taiwan, ROC
    J Leukoc Biol 72:207-16. 2002
    ..Taken together, PS-G elicitation of antiapoptotic effects on neutrophils primarily relies on activation of Akt-regulated signaling pathways...
  24. ncbi Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1
    Kuo I Lin
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 281:24111-23. 2006
    The polysaccharides of Ganoderma lucidum (Reishi) possess immunomodulation activities; however, their mode of molecular action in regulating each cellular subset in the immune system is still not clear...
  25. ncbi Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast
    Chang Hua Shang
    College of Life Sciences, Nanjing Agricultural University Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture
    Biosci Biotechnol Biochem 72:1333-9. 2008
    ..A reductase (HMGR) was isolated from a triterpene-producing fungus, Ganoderma lucidum (Reishi or Lingzhi)...
  26. ncbi Effect of a novel proteoglycan PTP1B inhibitor from Ganoderma lucidum on the amelioration of hyperglycaemia and dyslipidaemia in db/db mice
    Chen Dong Wang
    Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, People s Republic of China
    Br J Nutr 108:2014-25. 2012
    ..Therefore, FYGL is promising as an insulin sensitiser for the therapy of type 2 diabetes and accompanied dyslipidaemia...
  27. ncbi A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice
    Bao Song Teng
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, People s Republic of China
    J Agric Food Chem 59:6492-500. 2011
    ..The toxicity of FYGL is very low. The results indicate that FYGL may serve as a drug candidate or a health-care food for diabetic therapy or protection...
  28. ncbi Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression
    Nian Hong Chen
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Minhang, Shanghai 200240, China
    Pharmacol Rep 62:150-63. 2010
    ..Taken together, these results demonstrate that GA-T effectively inhibits cancer cell invasion in vitro and metastasis in vivo, and thus it may act as a potential drug for treating cancer...
  29. ncbi Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria
    Jie Liu
    Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Planta Med 76:137-9. 2010
    ..lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation...
  30. pmc Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e47873. 2012
    ..The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice...
  31. ncbi Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat
    Yihuai Gao
    New Zealand Institute of Natural Medicines, Auckland, New Zealand
    Life Sci 72:731-45. 2002
    ..05-1.0 mg/ml increased the c-Myc protein expression. These findings indicated that GLPS produced a mucosal healing effect in the rat model, perhaps due partly to the suppression of TNF-alpha and induction of c-myc and ODC gene...
  32. ncbi Biotechnological production and application of ganoderic acids
    Jun Wei Xu
    Key Laboratory of Microbial Metabolism Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
    Appl Microbiol Biotechnol 87:457-66. 2010
    ..The biosynthetic pathway of GAs is also outlined...
  33. ncbi Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae
    Horng Huey Ko
    Faculty of Fragrance and Cosmetics, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Phytochemistry 69:234-9. 2008
    ..Moreover, compound 9 was also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, which indicated 9 could protect keratinocytes from photodamage...
  34. pmc Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors
    Hassan Hajjaj
    Nestle Research Centre, Nestec Ltd, Vers chez les Blanc, P O Box 44, 1000 Lausanne 26, Switzerland
    Appl Environ Microbiol 71:3653-8. 2005
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine...
  35. ncbi Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum
    Ang Ren
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Nanjing 210095, Jiangsu Province, PR China
    Bioresour Technol 101:6785-90. 2010
    ..Quantification of transcription levels determined that MeJA significantly induced expression of these genes...
  36. pmc Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum
    Jun Wei Xu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Appl Environ Microbiol 78:7968-76. 2012
    ..This study demonstrates that transgenic basidiomycete G. lucidum is a promising system to achieve metabolic engineering of the ganoderic acid pathway...
  37. ncbi Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction
    Cui Xia Liang
    Molecular Biochemical Engineering Group, Key Laboratory of Microbial Metabolism Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
    Appl Microbiol Biotechnol 86:1367-74. 2010
    ..This work demonstrated a useful strategy for the enhanced production of ganoderic acids by G. lucidum...
  38. ncbi Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum
    Jun Wei Xu
    State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China
    Appl Microbiol Biotechnol 85:941-8. 2010
    ..The work is helpful to the production of individual GAs and provided an insight into why the liquid static culture was superior to the shaking culture in view of biosynthetic gene expression...
  39. ncbi Enhanced transformation of malachite green by laccase of Ganoderma lucidum in the presence of natural phenolic compounds
    Kumarasamy Murugesan
    School of Environmental Science and Engineering, POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, South Korea
    Appl Microbiol Biotechnol 82:341-50. 2009
    ..The results of the present study revealed that the natural phenolic compounds could alternatively be used as potential redox mediators for effective laccase-mediated decolorization of MG...
  40. ncbi Molecular cloning, characterization, and function analysis of a mevalonate pyrophosphate decarboxylase gene from Ganoderma lucidum
    Liang Shi
    Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, No 1 Weigang, Nanjing, 210095, Jiangsu, People s Republic of China
    Mol Biol Rep 39:6149-59. 2012
    ..lucidum. Additionally, this study provides an approach for improving triterpene content through the overexpression of a key gene...
  41. ncbi Molecular cloning and expression of a laccase from Ganoderma lucidum, and its antioxidative properties
    Seong Soo Joo
    Division and Institute of Life Sciences, Kangwon National University, Chuncheon 200 701, Korea
    Mol Cells 25:112-8. 2008
    ..GLlac1 was released from the cells when expressed in P. pastoris, and had high laccase activity. In addition, GLlac1 conferred antioxidative protection from protein degradation, and thus may be useful in bio-medical applications...
  42. ncbi Ganoderma lucidum in cancer research
    Daniel Sliva
    Leuk Res 30:767-8. 2006
  43. ncbi Cytotoxic triterpenoids from Ganoderma lucidum
    Chun Ru Cheng
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Phytochemistry 71:1579-85. 2010
    ..All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed...
  44. ncbi Effect of Reishi polysaccharides on human stem/progenitor cells
    Wan Yu Chen
    Genomics Research Center, Academia Sinica, No 128, Academia Road, Sec 2, Nankang, Taipei 115, Taiwan
    Bioorg Med Chem 18:8583-91. 2010
    ....
  45. ncbi Ganoderma lucidum and its pharmaceutically active compounds
    Bojana Boh
    Faculty of Natural Sciences and Engineering, University of Ljubljana, Vegova 4, 1000 Ljubljana, Slovenia
    Biotechnol Annu Rev 13:265-301. 2007
    ..In addition, polysaccharides have a protective effect against free radicals and reduce cell damage caused by mutagens...
  46. ncbi Molecular cloning, characterization, and differential expression of a farnesyl-diphosphate synthase gene from the basidiomycetous fungus Ganoderma lucidum
    Yi Xin Ding
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Jiangsu, PR China
    Biosci Biotechnol Biochem 72:1571-9. 2008
    ..Functional complementation of GlFPS in an ERG20-disrupted yeast strain indicated that the cloned cDNA encoded a farnesyl-diphosphate synthase...
  47. ncbi Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides
    Hung Sen Chen
    The Genomic Research Center, Academia Sinica, No 128 Academia road, Section 2, Nan Kang, Taipei 11529, Taiwan
    Bioorg Med Chem 12:5595-601. 2004
    We describe here the isolation of Reishi polysaccharides for the study of their effect on cytokine expression in mouse splenocytes...
  48. ncbi Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models
    Chia Jui Weng
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    J Agric Food Chem 57:5049-57. 2009
    ..These results suggest that the lucidenic acid-rich GLE could serve as a chemopreventive agent for the tumorigenesis and metastasis of highly invasive hepatoma cells...
  49. ncbi Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst
    X Bao
    Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, People's Republic of China
    Carbohydr Res 332:67-74. 2001
    ..The results suggested that the degree of substitution on the main chain and the length of side chains may be very important factors in determining the conformation and the biological activities of beta-(1-->3)-linked glucans...
  50. ncbi Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum
    Liang Guo
    Gene Research Center, Shanghai Medical College and Institutes of Biomedical Science of Fudan University, Shanghai, PR China
    Int Immunopharmacol 9:1175-82. 2009
    ..Therefore, these results suggest that GSG is an effective immunomodulator and may be a promising adjuvant remedy for anti-tumor therapies...
  51. ncbi p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells
    Nian Hong Chen
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR China
    Phytomedicine 18:719-25. 2011
    ..The results indicated that p53 played an important role in anti-invasion of GA-T in human carcinoma cells. p53 may be an important target for GA-T inhibiting human carcinoma cells anti-invasion...
  52. pmc The development and application of a multiple gene co-silencing system using endogenous URA3 as a reporter gene in Ganoderma lucidum
    Dashuai Mu
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Nanjing, Jiangsu, People s Republic of China
    PLoS ONE 7:e43737. 2012
    ....
  53. ncbi Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo
    Ljubica M Harhaji Trajkovic
    Institute for Biological Research Sinisa Stankovic, Belgrade University, Belgrade, Serbia
    Nutr Cancer 61:696-707. 2009
    ..Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers...
  54. ncbi Structural elucidation of the polysaccharide moiety of a glycopeptide (GLPCW-II) from Ganoderma lucidum fruiting bodies
    LiBin Ye
    College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Carbohydr Res 343:746-52. 2008
    ....
  55. ncbi Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats
    H Lu
    Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan
    Oncol Rep 8:1341-5. 2001
    ..In an additional in vitro experiment, MAK inhibited anchorage-independent growth of several colon carcinoma cell lines. The present results thus indicate that dietary MAK could act as a preventive agent for colon carcinogenesis...
  56. ncbi Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization
    Jun Wei Xu
    State Key Laboratory of Bioreactor Engineering, School of Biotechnology, corrected East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China
    Mol Biol Rep 39:3603-10. 2012
    ..The results of this study present the useful application of EST analysis on G. lucidum and provide preliminary indication of gene expression putatively involved in asexual sporulation process...
  57. ncbi Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum
    Wen Xian Zhang
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237, Shanghai, China
    Bioprocess Biosyst Eng 33:683-90. 2010
    ..The information obtained in this study provided an insight into the role of gaseous O(2) in the GA production and it will be helpful for further enhancing its productivity...
  58. ncbi Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells
    Chia Che Tsai
    Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan
    J Agric Food Chem 60:2830-7. 2012
    ..This oligosaccharide isolated from G. lucidum polysaccharides with internal glucuronic acids/glucose repeat unit in a 3:1 ratio may be responsible for the active stimulation of NK and T cells...
  59. ncbi Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum
    Yi Ning Xu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
    Biotechnol Adv 30:1301-8. 2012
    ..Based on the results obtained, a possible model on the effect of external calcium ion on the GAs biosynthesis via calcineurin signal transduction pathway was proposed...
  60. ncbi Transcriptome analysis of cadmium response in Ganoderma lucidum
    Huey Wen Chuang
    Department of BioAgricultural Sciences, National Chiayi University, Chiayi, Taiwan
    FEMS Microbiol Lett 293:205-13. 2009
    ..Our results provide a genome-wide transcriptome profiling of Cd response in Ganoderma species...
  61. ncbi Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells
    J T Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, USA
    Exp Oncol 28:25-9. 2006
    ..The effects of this medicinal mushroom on human colorectal cancer cells have not yet been evaluated. In this study, we investigated the effects of Ganoderma lucidum extract using SW 480 human colorectal cancer cell line...
  62. pmc Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models
    Ivette J Suarez-Arroyo
    Department of Biochemistry, Universidad Central del Caribe, School of Medicine, Bayamon, Puerto Rico, United States of America
    PLoS ONE 8:e57431. 2013
    The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer (IBC) using in vivo and in vitro IBC models...
  63. ncbi [Advances of pharmacological effects of triterpenes from Ganoderma lucidum]
    Jun Luo
    Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 37:574-8. 2002
  64. ncbi Enhanced production of ganoderic acids in static liquid culture of Ganoderma lucidum under nitrogen-limiting conditions
    Wei Zhao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China
    Bioresour Technol 102:8185-90. 2011
    ..This study demonstrated a useful strategy for enhancing GAs production and provided useful information for further investigation on its biosynthesis regulation...
  65. pmc Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer
    Michelle M Martínez-Montemayor
    Department of Biochemistry, Universidad Central del Caribe, School of Medicine, Bayamon, Puerto Rico
    Nutr Cancer 63:1085-94. 2011
    ..Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-IBC therapy...
  66. ncbi Comparative studies of various ganoderma species and their different parts with regard to their antitumor and immunomodulating activities in vitro
    Grace G L Yue
    Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Altern Complement Med 12:777-89. 2006
    Ganoderma lucidum (Lingzhi or Reishi) has been commonly suggested in East Asia as a potential candidate for prevention and treatment of different diseases, including cancer...
  67. ncbi Development of a simple and efficient transformation system for the basidiomycetous medicinal fungus Ganoderma lucidum
    Liang Shi
    Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, No 1 Weigang, Nanjing, 210095, Jiangsu, People s Republic of China
    World J Microbiol Biotechnol 28:283-91. 2012
    ..Our results demonstrate a new transgenic approach that will facilitate Ganoderma lucidum research...
  68. ncbi An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways
    Yu Li Lin
    Department of Medical Research, Institute of Microbiology and Biochemistry, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    J Leukoc Biol 86:877-89. 2009
    ..In conclusion, our experiments demonstrated that rLZ-8 can effectively promote the activation and maturation of immature DCs, preferring a Th1 response, suggesting that rLZ-8 may possess a potential effect in regulating immune responses...
  69. ncbi Cellular and physiological effects of Ganoderma lucidum (Reishi)
    Daniel Sliva
    Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:873-9. 2004
    ..Mushrooms such as Ganoderma lucidum (Reishi), Lentinus edodes (Shiitake), Grifola frondosa (Maitake), Hericium erinaceum (Yamabushitake), and Inonotus ..
  70. ncbi Effect of oxygen concentration in gas phase on sporulation and individual ganoderic acids accumulation in liquid static culture of Ganoderma lucidum
    Wen Xian Zhang
    East China University of Science and Technology, Shanghai, China
    J Biosci Bioeng 109:37-40. 2010
    ..A higher oxygen concentration increased individual GAs production, and more spores and higher total GA content were obtained at an oxygen level of 80%...
  71. ncbi The lifespan-promoting effect of acetic acid and Reishi polysaccharide
    Ming Hong Chuang
    Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
    Bioorg Med Chem 17:7831-40. 2009
    ..Among the substances tested, acetic acid and Reishi polysaccharide fraction 3 (RF3) were shown to increase the expression of the lifespan and longevity-related ..
  72. ncbi Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 215:15-26. 2008
    ..Our current results of analyzing rLZ-8-mediated signal transduction in T cells might provide a potential application for rLZ-8 as a pharmacological immune-modulating agent...
  73. ncbi Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice
    Yihuai Gao
    Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
    Immunol Invest 34:171-98. 2005
    ..The overall findings indicated that Ganopoly had antitumor activity with a broad spectrum of immuno-modulating activities and may represent a novel promising immunotherapeutic agent in cancer treatment...
  74. ncbi Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis
    Na Ding
    Laboratory of Analytical Biochemistry and Bioseparation, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    J Pharm Biomed Anal 53:1224-30. 2010
    ..4% to 103.6%. This was the first report on simultaneous determination of the four GAs and the results provided a firm basis for the trace analysis of GAs in dried fermentation mycelia powder of G. lucidum with high accuracy...
  75. ncbi Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity
    Masataka Fukuzawa
    Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8553, Japan
    Biol Pharm Bull 31:1933-7. 2008
    During our isolation of biologically active substances from the spores of Ganoderma lucidum (Reishi Houshi, G...
  76. ncbi Analysis of triterpenoids in ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry
    Min Yang
    Shanghai Research Center for TCM Modernization, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    J Am Soc Mass Spectrom 18:927-39. 2007
    ..2% acetic acid gradient. A total of 32 triterpenoids, including six new ones, were identified or tentatively characterized based on the tandem mass spectra of the HPLC peaks...
  77. ncbi Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress
    Seval Aydin
    Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Turkey
    Asian J Surg 33:173-80. 2010
    ..Cytoprotective effects of Ganoderma lucidum (GL) have previously been shown. In this study, the effects of GL on oxidative stress and oxidant DNA damage in experimental obstructive jaundice were evaluated...
  78. ncbi Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry
    Wei Ting Hung
    Genomics Research Center, Academia Sinica, No 128, Academia Road Section 2, Nan Kang, Taipei 11529, Taiwan
    Molecules 13:1538-50. 2008
    ..The G. lucidum glucan structure was determined and this method for linkage analysis of permethylated glucan has been proven feasible...
  79. ncbi Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice
    Qun Zhang
    Department of Applied Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0914, Japan
    Biol Pharm Bull 33:909-11. 2010
    ..These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR(2) and 5-HT(2A) receptors are the sites of its action...
  80. ncbi Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells
    Gwenaelle Stanley
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 330:46-52. 2005
    ..In summary, our results suggest that G. lucidum inhibits prostate cancer-dependent angiogenesis by modulating MAPK and Akt signaling and could have potential therapeutic use for the treatment of prostate cancer...
  81. ncbi Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006
    ..lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer...
  82. ncbi Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi)
    Michihiro Kohguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:881-7. 2004
    The immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi, RR), which has been used as a traditional supplement for human health, were investigated in mice...
  83. ncbi Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 24:1093-9. 2004
    Ganoderma lucidum (Reishi), an oriental medical mushroom, has been widely used in Asian countries for centuries to prevent or treat different diseases, including cancer...
  84. ncbi Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai, Taipei, Taiwan
    J Immunol 173:5989-99. 2004
    We have demonstrated that an extract of Ganoderma lucidum (Reishi or Ling-Zhi) polysaccharides (EORP) exerts immunomodulating activities by stimulating the expression of inflammatory cytokines from mouse spleen cells...
  85. ncbi Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides
    Li Zhen Cao
    Department of Pharmacology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Immunol Lett 83:163-9. 2002
    ..Gl-PS was shown to promote not only the maturation of cultured murine bone marrow derived DC in vitro, but also the immune response initiation induced by DC...
  86. ncbi Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell
    Hongbo Hu
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Sumon 441 744, Korea
    Int J Cancer 102:250-3. 2002
    ..Our findings suggest that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum...
  87. ncbi Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy
    Wing Keung Chan
    Department of Paediatrics and Adolescent Medicine, Hong Kong Jockey Club Clinical Research Centre, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Altern Complement Med 11:1047-57. 2005
    ..Dendritic cells (DCs) are professional antigen-presenting cells and their role in DC-based tumor vaccine has been well defined. The possibility of GL as natural adjuvant for human DCs remains unknown...
  88. ncbi Antiproliferative ability of a combination regimen of crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute myelogenous leukemia
    Chung Hin Chui
    Central Laboratory of the Institute of Molecular Technology for Drug Discovery and Synthesis, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, P R China
    Oncol Rep 16:1313-6. 2006
    ..An in vivo toxicity test revealed that no acute toxicity was observed after feeding the rats a high dosage of the CGG extract. Further animal model tests are necessary to investigate the possible chronic toxicity of the CGG extract...
  89. ncbi Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats
    Naoki Kashimoto
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Oncol Rep 16:1181-7. 2006
    ..The present results thus indicate that dietary supplementation with MAK inhibits the development of lung tumors, suggesting that MAK may be a potent chemopreventive agent against lung carcinogenesis...
  90. ncbi Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways
    Yu Li Lin
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Leukoc Biol 78:533-43. 2005
    ..Taken together, our data demonstrate that PS-G can effectively promote the activation and maturation of immature DC, suggesting that PS-G may possess a potential in regulating immune responses...
  91. ncbi Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
    Wen Tang
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
    Life Sci 80:205-11. 2006
    ..All our findings demonstrate that GA-T induced apoptosis of metastatic lung tumor cells through intrinsic pathway related to mitochondrial dysfunction and p53 expression, and it may be a potentially useful chemotherapeutic agent...
  92. ncbi Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
    Claudia I Muller
    Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Leuk Res 30:841-8. 2006
    ..These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies...
  93. ncbi Immune receptors for polysaccharides from Ganoderma lucidum
    Bao Mei Shao
    Department of Immunology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Biochem Biophys Res Commun 323:133-41. 2004
    ..Our results may have important implications for our understanding on the molecular mechanisms of immunopotentiating polysaccharides from traditional Chinese medicine...
  94. ncbi Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro
    Qing Yi Lu
    Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Lett 216:9-20. 2004
    ....
  95. ncbi Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells
    Kee Jong Hong
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Phytother Res 18:768-70. 2004
    ....
  96. ncbi Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro
    Qing Yi Lu
    Department of Medicine, Center for Human Nutrition, University of California Los Angeles, Los Angeles, CA 90095, USA
    Oncol Rep 12:659-62. 2004
    ..Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities...
  97. ncbi Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator
    Yi Hsia Liu
    Section of Allergy and Immunology, Cathay General Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 36:236-42. 2003
    ..These results suggest that Dp2 NT might have a therapeutic effect on Dp2-induced airway hypersensitivity and LZ OT might also have an effect on Dp2 NT immunotherapy...
  98. ncbi Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
    ..Because the dried powder of ganoderma is commercially available as a dietary supplement itself, the purpose of this study was to evaluate the biologic activity of samples of Ganoderma lucidum from different sources...
  99. ncbi Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice
    Yu Li Lin
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Mol Pharmacol 70:637-44. 2006
    ..Furthermore, the results also demonstrate that the data from microarray analysis could be correlated with the in vivo effect of the immune-enhancing compound...
  100. ncbi Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms
    Masanori Noguchi
    Department of Urology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Asian J Androl 10:777-85. 2008
    ....
  101. ncbi Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidum
    Chao Ma
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
    Phytomedicine 15:268-76. 2008
    ..The results of the present study help to provide insight into the immuno-modulating activities of GL-SP...

Research Grants2

  1. Effect of Mushroom Extracts on Prostate Cancer
    Joel Slaton; Fiscal Year: 2003
    ..Ganoderma Lucidum (Reishi) contain a number of bioactive compounds including triterpenes which can down-regulate MMP-9, a member of the ..
  2. Role of Reishi on cell surface proteins and signaling modulation in IBC
    IVETTE SUAREZ; Fiscal Year: 2013
    ..We recently published that Ganoderma lucidum (Reishi), a mushroom used in Traditional Chinese Medicine, selectively inhibits IBC cell viability, but not viability of ..