fungi

Summary

Summary: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.

Top Publications

  1. ncbi Transcriptional regulation of plant cell wall degradation by filamentous fungi
    Nina Aro
    VTT Biotechnology, Espoo, Finland
    FEMS Microbiol Rev 29:719-39. 2005
  2. pmc ITS as an environmental DNA barcode for fungi: an in silico approach reveals potential PCR biases
    Eva Bellemain
    National Centre for Biosystematics, University of Oslo, Norway
    BMC Microbiol 10:189. 2010
  3. ncbi Perspectives of microbial oils for biodiesel production
    Qiang Li
    Department of Chemical Engineering, Tsinghua University, Beijing, 100084, People s Republic of China
    Appl Microbiol Biotechnol 80:749-56. 2008
  4. ncbi Nep1-like proteins from plant pathogens: recruitment and diversification of the NPP1 domain across taxa
    Mark Gijzen
    Agriculture and Agri Food Canada, 1391 Sandford Street, London, Ont, Canada N5V 4T3
    Phytochemistry 67:1800-7. 2006
  5. pmc Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi
    Conrad L Schoch
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:6241-6. 2012
  6. ncbi Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins
    Özgür Bayram
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat Gottingen, Gottingen, Germany
    FEMS Microbiol Rev 36:1-24. 2012
  7. ncbi Quantifying microbial communities with 454 pyrosequencing: does read abundance count?
    Anthony S Amend
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Mol Ecol 19:5555-65. 2010
  8. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
  9. ncbi Phylogenetic reference data for systematics and phylotaxonomy of arbuscular mycorrhizal fungi from phylum to species level
    Manuela Kruger
    Department of Biology, Genetics, Ludwig Maximilians University, Grosshaderner Street 4, 82152 Planegg Martinsried, Germany
    New Phytol 193:970-84. 2012
  10. ncbi Horizontal gene transfer in fungi
    David A Fitzpatrick
    Genome Evolution Laboratory, Department of Biology, The National University of Ireland Maynooth, Maynooth, Ireland
    FEMS Microbiol Lett 329:1-8. 2012

Detail Information

Publications338 found, 100 shown here

  1. ncbi Transcriptional regulation of plant cell wall degradation by filamentous fungi
    Nina Aro
    VTT Biotechnology, Espoo, Finland
    FEMS Microbiol Rev 29:719-39. 2005
    ..These biopolymers are degraded by many microorganisms, in particular filamentous fungi, with the aid of extracellular enzymes...
  2. pmc ITS as an environmental DNA barcode for fungi: an in silico approach reveals potential PCR biases
    Eva Bellemain
    National Centre for Biosystematics, University of Oslo, Norway
    BMC Microbiol 10:189. 2010
    ..We performed in silico PCR analyses with commonly used primer combinations using various ITS datasets obtained from public databases as templates...
  3. ncbi Perspectives of microbial oils for biodiesel production
    Qiang Li
    Department of Chemical Engineering, Tsinghua University, Beijing, 100084, People s Republic of China
    Appl Microbiol Biotechnol 80:749-56. 2008
    ..development of microbial, oils and it has been found that many microorganisms, such as algae, yeast, bacteria, and fungi, have the ability to accumulate oils under some special cultivation conditions...
  4. ncbi Nep1-like proteins from plant pathogens: recruitment and diversification of the NPP1 domain across taxa
    Mark Gijzen
    Agriculture and Agri Food Canada, 1391 Sandford Street, London, Ont, Canada N5V 4T3
    Phytochemistry 67:1800-7. 2006
    ..Interest in NLPs is gaining momentum as more members of this protein family are discovered in more species of plant pathogens...
  5. pmc Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi
    Conrad L Schoch
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:6241-6. 2012
    Six DNA regions were evaluated as potential DNA barcodes for Fungi, the second largest kingdom of eukaryotic life, by a multinational, multilaboratory consortium...
  6. ncbi Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins
    Özgür Bayram
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat Gottingen, Gottingen, Germany
    FEMS Microbiol Rev 36:1-24. 2012
    Filamentous fungi produce a number of small bioactive molecules as part of their secondary metabolism ranging from benign antibiotics such as penicillin to threatening mycotoxins such as aflatoxin...
  7. ncbi Quantifying microbial communities with 454 pyrosequencing: does read abundance count?
    Anthony S Amend
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Mol Ecol 19:5555-65. 2010
    ..read abundance and biological abundance in a sample of house dust spiked with known quantities and identities of fungi along a dilution gradient. Our results show one order of magnitude differences in read abundance among species...
  8. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
    ..increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe ..
  9. ncbi Phylogenetic reference data for systematics and phylotaxonomy of arbuscular mycorrhizal fungi from phylum to species level
    Manuela Kruger
    Department of Biology, Genetics, Ludwig Maximilians University, Grosshaderner Street 4, 82152 Planegg Martinsried, Germany
    New Phytol 193:970-84. 2012
    Although the molecular phylogeny, evolution and biodiversity of arbuscular mycorrhizal fungi (AMF) are becoming clearer, phylotaxonomically reliable sequence data are still limited...
  10. ncbi Horizontal gene transfer in fungi
    David A Fitzpatrick
    Genome Evolution Laboratory, Department of Biology, The National University of Ireland Maynooth, Maynooth, Ireland
    FEMS Microbiol Lett 329:1-8. 2012
    ..sampled eukaryotic lineages and is at the forefront of eukaryote comparative genomics and enables us to use fungi to study eukaryotic evolutionary mechanisms including HGT...
  11. ncbi Regulation of secondary metabolism in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Annu Rev Phytopathol 43:437-58. 2005
    ..genes to global regulators balancing growth, sporulation, and secondary metabolite production in selected fungi with emphasis on regulation of metabolites of agricultural concern...
  12. ncbi Fungal endophytes: diversity and functional roles
    R J Rodriguez
    US Geological Survey, Seattle, WA, USA
    New Phytol 182:314-30. 2009
    All plants in natural ecosystems appear to be symbiotic with fungal endophytes. This highly diverse group of fungi can have profound impacts on plant communities through increasing fitness by conferring abiotic and biotic stress ..
  13. pmc Rhizosphere communities of genetically modified zeaxanthin-accumulating potato plants and their parent cultivar differ less than those of different potato cultivars
    Nicole Weinert
    Julius Kühn Institut Federal Research Centre for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics, Braunschweig, Germany
    Appl Environ Microbiol 75:3859-65. 2009
    ..of Bacteria, Actinobacteria, Alpha- and Betaproteobacteria, Bacillus, Streptomycetaceae, Pseudomonas, gacA, Fungi, and Ascomycetes...
  14. pmc Active and total microbial communities in forest soil are largely different and highly stratified during decomposition
    Petr Baldrian
    Laboratory of Environmental Microbiology, Institute of Microbiology of the ASCR, v v i, Videnska, Praha, Czech Republic
    ISME J 6:248-58. 2012
    ..By the independent analysis of DNA and RNA, whole communities of bacteria and fungi and its active members were compared in topsoil of a Picea abies forest during a period of organic matter ..
  15. ncbi The cell wall: a carbohydrate armour for the fungal cell
    Jean Paul Latge
    Unite des Aspergillus, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France
    Mol Microbiol 66:279-90. 2007
    ..To date, only beta1,3 glucan synthase inhibitors have been launched clinically and many more targets remain to be explored...
  16. ncbi Lateral transfer of genes from fungi underlies carotenoid production in aphids
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, 1041 East Lowell Street, University of Arizona, Tucson, AZ 85721, USA
    Science 328:624-7. 2010
    Carotenoids are colored compounds produced by plants, fungi, and microorganisms and are required in the diet of most animals for oxidation control or light detection...
  17. ncbi Soil bacterial and fungal communities across a pH gradient in an arable soil
    Johannes Rousk
    Department of Microbial Ecology, Lund University, Ecology Building, Lund, Sweden
    ISME J 4:1340-51. 2010
    ..to investigate the direct influence of pH on the abundance and composition of the two major soil microbial taxa, fungi and bacteria...
  18. ncbi 454 Pyrosequencing analyses of forest soils reveal an unexpectedly high fungal diversity
    M Buee
    INRA, UMR 1136 INRA Nancy Université Interactions Arbres Microorganismes, INRA Nancy, 54280 Champenoux, France
    New Phytol 184:449-56. 2009
    Soil fungi play a major role in ecological and biogeochemical processes in forests...
  19. pmc The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion
    Jeffrey J Coleman
    Department of Plant Sciences, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 5:e1000618. 2009
    ..Two classes of genes have contributed to gene expansion: specific genes that are not found in other fungi including its closest sequenced relative, Fusarium graminearum; and genes that commonly occur as single copies in ..
  20. pmc PCR primers that amplify fungal rRNA genes from environmental samples
    J Borneman
    Department of Plant Pathology, University of California, Riverside, California 92521, USA
    Appl Environ Microbiol 66:4356-60. 2000
    Two PCR primer pairs were designed to amplify rRNA genes (rDNA) from all four major phyla of fungi: Ascomycota, Basidiomycota, Chytridomycota, and Zygomycota...
  21. pmc Comparative genomics of xylose-fermenting fungi for enhanced biofuel production
    Dana J Wohlbach
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 108:13212-7. 2011
    ..for subsequent microbial engineering, we sequenced the genomes of two xylose-fermenting, beetle-associated fungi, Spathaspora passalidarum and Candida tenuis...
  22. ncbi Natural products of filamentous fungi: enzymes, genes, and their regulation
    Dirk Hoffmeister
    Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    Nat Prod Rep 24:393-416. 2007
    ..genes, and whole gene clusters underlying natural product biosyntheses and their regulation in filamentous fungi. We have included literature references from 1958, yet the majority of citations are between 1995 and the present...
  23. pmc Obligate biotrophy features unraveled by the genomic analysis of rust fungi
    Sebastien Duplessis
    Unité Mixte de Recherche 1136, Institut National de la Recherche Agronomique Nancy Université, Interactions Arbres Micro organismes, Centre de Nancy, 54280 Champenoux, France
    Proc Natl Acad Sci U S A 108:9166-71. 2011
    Rust fungi are some of the most devastating pathogens of crop plants. They are obligate biotrophs, which extract nutrients only from living plant tissues and cannot grow apart from their hosts...
  24. pmc The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi
    Arunkumar Krishnan
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e29817. 2012
    ..GRAFS families are well represented in the Metazoan lineages, but they have not been shown to be present in Fungi. Here, we systematically mined 79 fungal genomes and provide the first evidence that four of the five main ..
  25. ncbi The origins of genome complexity
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 302:1401-4. 2003
    ..The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies...
  26. ncbi Mycoviruses of filamentous fungi and their relevance to plant pathology
    Michael N Pearson
    School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Mol Plant Pathol 10:115-28. 2009
    Mycoviruses (fungal viruses) are reviewed with emphasis on plant pathogenic fungi. Based on the presence of virus-like particles and unencapsidated dsRNAs, mycoviruses are common in all major fungal groups...
  27. pmc Phylogenomic analysis demonstrates a pattern of rare and ancient horizontal gene transfer between plants and fungi
    Thomas A Richards
    Centre for Eukaryotic Evolutionary Microbiology, School of Biosciences, University of Exeter, Exeter, EX4 4QD, United Kingdom
    Plant Cell 21:1897-911. 2009
    ..and eukaryotic species and identify 1689 genes that show the highest similarity to corresponding genes from fungi. We constructed a phylogeny for all 1689 genes identified and all homolog groups available from the rice (Oryza ..
  28. ncbi Dating divergences in the Fungal Tree of Life: review and new analyses
    John W Taylor
    Department of Plant and Microbial Biology, University of California, Berkeley 94720 3102, USA
    Mycologia 98:838-49. 2006
    ..history of dating fungal divergences by nucleic acid variation and then use a dataset of 50 genes for 25 selected fungi, plants and animals to investigate divergence times in kingdom Fungi...
  29. pmc Secondary metabolism in fungi: does chromosomal location matter?
    Jonathan M Palmer
    Plant Pathology Department, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 13:431-6. 2010
    Filamentous fungi produce a vast array of small molecules called secondary metabolites, which include toxins as well as antibiotics...
  30. pmc Assessment of soil microbial community structure by use of taxon-specific quantitative PCR assays
    Noah Fierer
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Appl Environ Microbiol 71:4117-20. 2005
    ..a quantitative PCR-based approach to estimating the relative abundances of major taxonomic groups of bacteria and fungi in soil. Primers were thoroughly tested for specificity, and the method was applied to three distinct soils...
  31. ncbi Heterotrimeric G protein signaling in filamentous fungi
    Liande Li
    Department of Plant Pathology and Microbiology, University of California, Riverside, California 92521, USA
    Annu Rev Microbiol 61:423-52. 2007
    Filamentous fungi are multicellular eukaryotic organisms known for nutrient recycling as well as for antibiotic and food production...
  32. ncbi Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi
    Nicolas Rispail
    Departamento de Genetica, Universidad de Cordoba, Cordoba, Spain
    Fungal Genet Biol 46:287-98. 2009
    ..model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina...
  33. ncbi The endophytic continuum
    Barbara Schulz
    Institute of Microbiology, Technical University of Braunschweig, Spielmannstrasse 7, D 38106 Braunschweig, Germany
    Mycol Res 109:661-86. 2005
    ..being employed for all organisms that inhabit plants, mycologists have come to use the term 'fungal endophyte' for fungi that inhabit plants without causing visible disease symptoms...
  34. ncbi Biodegradation of lignocellulosics: microbial, chemical, and enzymatic aspects of the fungal attack of lignin
    Angel T Martinez
    Biological Research Center, CSIC, Madrid, Spain
    Int Microbiol 8:195-204. 2005
    ..This review describes the composition of lignocellulosic materials, the different processes by which fungi are able to alter wood, including decay patterns caused by white, brown, and soft-rot fungi, and fungal staining ..
  35. pmc Contrasting soil pH effects on fungal and bacterial growth suggest functional redundancy in carbon mineralization
    Johannes Rousk
    Department of Microbial Ecology, Lund University, Ecology Building, SE 223 62 Lund, Sweden
    Appl Environ Microbiol 75:1589-96. 2009
    The influence of pH on the relative importance of the two principal decomposer groups in soil, fungi and bacteria, was investigated along a continuous soil pH gradient at Hoosfield acid strip at Rothamsted Research in the United Kingdom...
  36. ncbi Current state and perspectives of fungal DNA barcoding and rapid identification procedures
    Dominik Begerow
    Ruhr Universitat Bochum, Geobotanik ND03 174, Universitatsstr 150, 44801 Bochum, Germany
    Appl Microbiol Biotechnol 87:99-108. 2010
    ..full potential of these exciting techniques by accelerating biodiversity assessments, identification procedures of fungi need to be adapted to the emerging demands of modern large-scale ecological studies...
  37. pmc Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
    Mahmoud A Ghannoum
    Center for Medical Microbiology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS Pathog 6:e1000713. 2010
    ..In this study, we used a novel multitag pyrosequencing approach to characterize fungi present in the oral cavity of 20 healthy individuals, using the pan-fungal internal transcribed spacer (ITS) ..
  38. ncbi Contribution of proteomics to the study of plant pathogenic fungi
    Raquel González-Fernández
    Agroforestry and Plant Biochemistry and Proteomics Research Group, Department of Biochemistry and Molecular Biology, University of Cordoba, Agrifood Campus of International Excellence, ceiA3, 14071 Cordoba, Spain
    J Proteome Res 11:3-16. 2012
    Phytopathogenic fungi are one of the most damaging plant parasitic organisms, and can cause serious diseases and important yield losses in crops...
  39. ncbi Dectin-1 and Dectin-2 in innate immunity against fungi
    Shinobu Saijo
    Department of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260 8673, Japan
    Int Immunol 23:467-72. 2011
    ..Both β-glucans and α-mannans are major cell wall components of fungi including Candida albicans and Pneumocystis carinii...
  40. ncbi ITS-1 versus ITS-2 pyrosequencing: a comparison of fungal populations in truffle grounds
    Antonietta Mello
    Istituto per la Protezione delle Piante del CNR, Sezione di Torino, Viale Mattioli 25, 10125 Torino, Italy
    Mycologia 103:1184-93. 2011
    ....
  41. ncbi Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
    Sung Kuk Lee
    Joint BioEnergy Institute, Emeryville, CA 95608, USA
    Curr Opin Biotechnol 19:556-63. 2008
    ....
  42. pmc Genetic regulation of nitrogen metabolism in the fungi
    G A Marzluf
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Microbiol Mol Biol Rev 61:17-32. 1997
    In the fungi, nitrogen metabolism is controlled by a complex genetic regulatory circuit which ensures the preferential use of primary nitrogen sources and also confers the ability to use many different secondary nitrogen sources when ..
  43. ncbi Lignocellulosic residues: biodegradation and bioconversion by fungi
    Carmen Sanchez
    Research Centre for Biological Sciences, Universidad Autonoma de Tlaxcala, Tlaxcala, Mexico
    Biotechnol Adv 27:185-94. 2009
    The ability of fungi to degrade lignocellulosic materials is due to their highly efficient enzymatic system...
  44. pmc Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi
    Nora Khaldi
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Genome Biol 9:R18. 2008
    Filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. Genes from the same pathway are often clustered and co-expressed in particular conditions...
  45. ncbi Plants, mycorrhizal fungi, and bacteria: a network of interactions
    Paola Bonfante
    Dipartimento di Biologia Vegetale dell Università di Torino and Istituto di Protezione delle Piante del CNR, Sezione di Torino, Torino 10125, Italy
    Annu Rev Microbiol 63:363-83. 2009
    This review focuses on interactions among plants, mycorrhizal fungi, and bacteria, testing the hypothesis whether mycorrhizas can be defined as tripartite associations...
  46. ncbi The fungi: 1, 2, 3 ... 5.1 million species?
    Meredith Blackwell
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Am J Bot 98:426-38. 2011
    b>Fungi are major decomposers in certain ecosystems and essential associates of many organisms. They provide enzymes and drugs and serve as experimental organisms. In 1991, a landmark paper estimated that there are 1...
  47. pmc Regulation of secondary metabolism by chromatin structure and epigenetic codes
    Joseph Strauss
    Fungal Genetics and Genomics Unit, AIT Austrian Institute of Technology and BOKU University Vienna, Muthgasse 18, A 1190 Vienna, Austria
    Fungal Genet Biol 48:62-9. 2011
    ....
  48. pmc An insect herbivore microbiome with high plant biomass-degrading capacity
    Garret Suen
    Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 6:e1001129. 2010
    ..Given the recent interest in cellulosic biofuels, understanding how large-scale and rapid plant biomass degradation occurs in a highly evolved insect herbivore is of particular relevance for bioenergy...
  49. ncbi Having sex, yes, but with whom? Inferences from fungi on the evolution of anisogamy and mating types
    Sylvain Billiard
    Universite Lille Nord de France, USTL, GEPV, CNRS, FRE 3268, Villeneuve d Ascq, France
    Biol Rev Camb Philos Soc 86:421-42. 2011
    ..We argue that fungi represent highly suitable models to help resolve issues related to the evolution of distinct gamete classes, ..
  50. pmc A fungal phylogeny based on 82 complete genomes using the composition vector method
    Hao Wang
    T life Research Center, Department of Physics, Fudan University, Shanghai 200433, PR China
    BMC Evol Biol 9:195. 2009
    ..The ever-increasing number of sequenced fungal genomes and the recent success of our newly proposed alignment-free composition vector tree (CVTree, see Methods) approach have made the verification feasible...
  51. ncbi Fungal endophytes: unique plant inhabitants with great promises
    Amal Hassan Aly
    Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany
    Appl Microbiol Biotechnol 90:1829-45. 2011
    ..Furthermore, the chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents ..
  52. pmc Analysis of fungal diversity in the wheat rhizosphere by sequencing of cloned PCR-amplified genes encoding 18S rRNA and temperature gradient gel electrophoresis
    E Smit
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment RIVM, NL 3720 BA Bilthoven, The Netherlands
    Appl Environ Microbiol 65:2614-21. 1999
    Like bacteria, fungi play an important role in the soil ecosystem...
  53. ncbi Regulation of plasma membrane H(+)-ATPase in fungi and plants
    F Portillo
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, E 28029, Madrid, Spain
    Biochim Biophys Acta 1469:31-42. 2000
    The plasma membrane H+-ATPase from fungi and plants is a proton pump which plays a key role in the physiology of these organisms controlling essential functions such as nutrient uptake and intracellular pH regulation...
  54. ncbi Global patterns of foliar nitrogen isotopes and their relationships with climate, mycorrhizal fungi, foliar nutrient concentrations, and nitrogen availability
    Joseph M Craine
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    New Phytol 183:980-92. 2009
    ..Global-scale comparisons of other components of the N cycle are still required for better mechanistic understanding of the determinants of variation in foliar delta(15)N and ultimately global patterns in N cycling...
  55. ncbi Regulation of multidrug resistance in pathogenic fungi
    Joachim Morschhäuser
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Fungal Genet Biol 47:94-106. 2010
    Infections by opportunistic pathogenic fungi, especially Candida species, Cryptococcus neoformans, and Aspergillus fumigatus, are a serious medical problem in immunocompromised patients...
  56. ncbi Fungal effector proteins: past, present and future
    Pierre J G M de Wit
    Wageningen University and Research Centre, Laboratory of Phytopathology, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
    Mol Plant Pathol 10:735-47. 2009
    ..organisms, but, currently, the availability of many sequenced fungal genomes allows their cloning from additional fungi by a combination of comparative and functional genomics...
  57. ncbi Hidden fungi, emergent properties: endophytes and microbiomes
    Andrea Porras-Alfaro
    Department of Biology, Western Illinois University, Macomb, IL 61455, USA
    Annu Rev Phytopathol 49:291-315. 2011
    ..g., mycorrhizal fungi, pathogens, epiphytes, and saprotrophs...
  58. ncbi Birth of new spliceosomal introns in fungi by multiplication of introner-like elements
    Ate van der Burgt
    Laboratory of Phytopathology, Wageningen University, 6708PB Wageningen, The Netherlands
    Curr Biol 22:1260-5. 2012
    ..We suggest that ILEs not only account for intron gains in six fungi but also in ancestral eukaryotes to give rise to most RSIs by a yet unknown multiplication mechanism.
  59. ncbi Pathways for degradation of lignin in bacteria and fungi
    Timothy D H Bugg
    Department of Chemistry, University of Warwick, Coventry, UK
    Nat Prod Rep 28:1883-96. 2011
    ..White-rot fungi are known to break down lignin with the aid of extracellular peroxidase and laccase enzymes...
  60. pmc Assessment of bias associated with incomplete extraction of microbial DNA from soil
    Larry M Feinstein
    Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Appl Environ Microbiol 75:5428-33. 2009
    ..used, a significant shift in community composition due to extraction bias was detected for bacteria but not for fungi. Pyrosequencing indicated that the relative abundances of sequences from rarely cultivated groups such as ..
  61. ncbi Viruses of plant pathogenic fungi
    Said A Ghabrial
    Plant Pathology Department, University of Kentucky, Lexington, Kentucky 40546, USA
    Annu Rev Phytopathol 47:353-84. 2009
    Mycoviruses are widespread in all major groups of plant pathogenic fungi. They are transmitted intracellularly during cell division, sporogenesis, and cell fusion, but apparently lack an extracellular route for infection...
  62. ncbi Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi
    Enrique Navarro
    Swiss Federal Institute of Aquatic Science and Technology EAWAG, Ueberlandstrasse 133, Dubendorf 8600, Switzerland
    Ecotoxicology 17:372-86. 2008
    ..and thus for their mobility in aquatic and terrestrial systems and for their interactions with algae, plants and, fungi. Interactions of ENPs with natural organic matter have to be considered as well, as those will alter the ENPs ..
  63. ncbi Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and -independent analysis of faeces
    Pauline D Scanlan
    Alimentary Pharmabiotic Centre, Department of Microbiology, University College Cork, Cork, Ireland
    ISME J 2:1183-93. 2008
    ..18S rRNA genes and fungal internal transcribed regions (ITS), together with culture-dependent analyses of fungi, were performed on a group of healthy volunteers. Temporal analysis was also included wherever possible...
  64. pmc Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis
    Ephraim L Tsalik
    Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
    J Clin Microbiol 48:26-33. 2010
    ..Real-time multiplex PCR has the potential to serve as an adjunct to conventional blood culture, adding diagnostic yield and shortening the time to pathogen identification...
  65. pmc The role of effectors of biotrophic and hemibiotrophic fungi in infection
    Markus Koeck
    CSIRO Plant Industry, Canberra, ACT 2601, Australia
    Cell Microbiol 13:1849-57. 2011
    Biotrophic and hemibiotrophic fungi are successful groups of plant pathogens that require living plant tissue to survive and complete their life cycle...
  66. pmc Indoor fungal composition is geographically patterned and more diverse in temperate zones than in the tropics
    Anthony S Amend
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    Proc Natl Acad Sci U S A 107:13748-53. 2010
    b>Fungi are ubiquitous components of indoor human environments, where most contact between humans and microbes occurs. The majority of these organisms apparently play a neutral role, but some are detrimental to human lifestyles and health...
  67. ncbi Beta-glucan recognition by the innate immune system
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 230:38-50. 2009
    ....
  68. pmc Bioprospecting for microbial endophytes and their natural products
    Gary Strobel
    Department of Plant Sciences, Montana State University, Bozeman, Montana 59717, USA
    Microbiol Mol Biol Rev 67:491-502. 2003
    ..The potential prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great...
  69. ncbi Reactive oxygen species and development in microbial eukaryotes
    Jesús Aguirre
    Departamento de Genetica Molecular, Instituto de Fisiología Celular UNAM, Apartado Postal 70 242, 04510 Mexico, D F, Mexico
    Trends Microbiol 13:111-8. 2005
    ..This shows that manipulation of reactive species, as strategy to regulate cell differentiation, is ubiquitous in eukaryotes and suggests that such strategy was selected early in evolution...
  70. ncbi Massively parallel 454 sequencing indicates hyperdiverse fungal communities in temperate Quercus macrocarpa phyllosphere
    A Jumpponen
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    New Phytol 184:438-48. 2009
    ..The two land-use types contained communities that were distinct and more than 10% of the molecular OTUs differed in their frequency...
  71. ncbi Fungal laccases - occurrence and properties
    Petr Baldrian
    Laboratory of Biochemistry of Wood rotting Fungi, Institute of Microbiology ASCR, Prague, Czech Republic
    FEMS Microbiol Rev 30:215-42. 2006
    Laccases of fungi attract considerable attention due to their possible involvement in the transformation of a wide variety of phenolic compounds including the polymeric lignin and humic substances...
  72. ncbi The new higher level classification of eukaryotes with emphasis on the taxonomy of protists
    Sina M Adl
    Department of Biology, Dalhousie University, Halifax, NS B3H 4J1, Canada
    J Eukaryot Microbiol 52:399-451. 2005
    ..quot; The multicellular lineages emerged from within monophyletic protist lineages: animals and fungi from Opisthokonta, plants from Archaeplastida, and brown algae from Stramenopiles.
  73. ncbi Natural functions of mycotoxins and control of their biosynthesis in fungi
    Massimo Reverberi
    Department of Plant Biology, University Sapienza, L go Cristina di Svezia 24, 00165, Rome, Italy
    Appl Microbiol Biotechnol 87:899-911. 2010
    Mycotoxins are harmful secondary metabolites produced by a range of widespread fungi belonging in the main to Fusarium, Aspergillus and Penicillium genera...
  74. pmc OrthoDB: the hierarchical catalog of eukaryotic orthologs
    Evgenia V Kriventseva
    Department of Genetic Medicine and Development, University of Geneva Medical School, Swiss Institute of Bioinformatics, 1 rue Michel Servet, Geneva, Switzerland
    Nucleic Acids Res 36:D271-5. 2008
    ..all-against-all Smith-Waterman sequence comparisons to analyze 58 eukaryotic genomes, focusing on vertebrates, insects and fungi to facilitate further comparative studies. The database is freely available at http://cegg.unige.ch/orthodb.
  75. pmc C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi
    Marein A W P de Jong
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Immunol 47:1216-25. 2010
    ..tissues are the first antigen presenting cells to encounter invading pathogens, such as viruses, bacteria and fungi. Fungal infections form a health threat especially in immuno-compromised individuals...
  76. pmc Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi
    Chaoyang Xue
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    FEMS Microbiol Rev 32:1010-32. 2008
    ..Here, we compare research on GPCRs in fungi with information derived from mammalian systems to provide a useful road map on how to better understand ligand-..
  77. ncbi Role of mini-host models in the study of medically important fungi
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Lancet Infect Dis 7:42-55. 2007
    ..A growing number of medically important fungi, including Aspergillus spp, Candida spp, Cryptococcus spp, and species in the class Zygomycetes, have been shown ..
  78. ncbi Symbiotic nitrogen fixation in the fungus gardens of leaf-cutter ants
    Adrián A Pinto-Tomás
    Department of Bacteriology, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    Science 326:1120-3. 2009
    ..The discovery of N2 fixation within the leaf-cutter ant-microbe symbiosis reveals a previously unrecognized nitrogen source in neotropical ecosystems...
  79. ncbi Adherence mechanisms in human pathogenic fungi
    Guy Tronchin
    Groupe d Etude des Interactions Hote Pathogene, UPRES EA 3142, Universite d Angers, Angers Cedex
    Med Mycol 46:749-72. 2008
    Interactions of human pathogenic fungi with the host tissues are key factors in the pathogenesis of mycoses...
  80. ncbi Assessing the performance of single-copy genes for recovering robust phylogenies
    G Aguileta
    Laboratoire Ecologie, Systematique et Evolution, Universite Paris Sud, Orsay, UMR8079, Orsay, Cedex, France
    Syst Biol 57:613-27. 2008
    ..b>Fungi represent a model group for phylogenomics because many complete fungal genomes are available...
  81. pmc Fungal community analysis by large-scale sequencing of environmental samples
    Heath E O'Brien
    Department of Biology, Duke University, Durham NC 27708
    Appl Environ Microbiol 71:5544-50. 2005
    b>Fungi are an important and diverse component of soil communities, but these communities have proven difficult to study in conventional biotic surveys...
  82. pmc The lysin motif receptor-like kinase (LysM-RLK) CERK1 is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation
    Elena K Petutschnig
    Department of Plant Cell Biology, Albrecht von Haller Institute of Plant Sciences, Georg August University Goettingen, Untere Karspuele 2, D 37073 Goettingen, Germany
    J Biol Chem 285:28902-11. 2010
    ..Collectively, our data suggest that in Arabidopsis, CERK1 is a major chitin, chitosan, and chito-oligomer binding component and that chitin signaling depends on CERK1 post-translational modification and kinase activity...
  83. pmc Multiple GAL pathway gene clusters evolved independently and by different mechanisms in fungi
    Jason C Slot
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 107:10136-41. 2010
    ..of gene sequences and order in the galactose utilization (GAL) pathway in whole-genome data from 80 diverse fungi. We found that GAL gene clusters originated independently and by different mechanisms in three unrelated yeast ..
  84. ncbi A meta-analysis of context-dependency in plant response to inoculation with mycorrhizal fungi
    Jason D Hoeksema
    Department of Biology, University of Mississippi, University, MS 38677, USA
    Ecol Lett 13:394-407. 2010
    Ecology Letters (2010) 13: 394-407 Abstract Mycorrhizal fungi influence plant growth, local biodiversity and ecosystem function. Effects of the symbiosis on plants span the continuum from mutualism to parasitism...
  85. pmc Fungi unearthed: transcripts encoding lignocellulolytic and chitinolytic enzymes in forest soil
    Harald Kellner
    Unité de Biologie Animale et Microbienne, Gembloux Agro Bio Tech, Universite de Liege, Gembloux, Belgium
    PLoS ONE 5:e10971. 2010
    b>Fungi are the main organisms responsible for the degradation of biopolymers such as lignin, cellulose, hemicellulose, and chitin in forest ecosystems. Soil surveys largely target fungal diversity, paying less attention to fungal activity.
  86. ncbi Ectomycorrhizal lifestyle in fungi: global diversity, distribution, and evolution of phylogenetic lineages
    Leho Tedersoo
    Institute of Ecology and Earth Sciences and Natural History Museum of Tartu University, 40 Lai Street, 51005, Tartu, Estonia
    Mycorrhiza 20:217-63. 2010
    ..This review aims to: (1) critically assess the current knowledge of the fungi involved in the EcM by integrating data from axenic synthesis trials, anatomical, molecular, and isotope studies; (..
  87. pmc Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi
    Jianming Chen
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Proc Natl Acad Sci U S A 107:20774-9. 2010
    ..Together, our data demonstrate that the p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection...
  88. pmc A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis
    Dongtao Ren
    State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
    Proc Natl Acad Sci U S A 105:5638-43. 2008
    ..These results indicate that the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection...
  89. ncbi Speciation in fungi
    Tatiana Giraud
    Ecologie, Systematique et Evolution, UMR 8079 CNRS, ESE, Bâtiment 360 Université Paris Sud, 91405 Orsay Cedex, France
    Fungal Genet Biol 45:791-802. 2008
    ..We then review recent developments in the understanding of modes of speciation in fungi. Allopatric speciation raises no theoretical problem and numerous fungal examples exist from nature...
  90. ncbi Lipid signaling in pathogenic fungi
    John M Shea
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Opin Microbiol 9:352-8. 2006
    ..the importance of lipid signaling molecules in the development and pathogenicity of clinically important fungi. In Cryptococcus neoformans, sphingolipid-derived diacylglycerol has been shown to induce the transcription of the ..
  91. pmc Marine drugs from sponge-microbe association--a review
    Tresa Remya A Thomas
    Biological Oceanography, National Institute of Oceanography, Dona Paula, Goa, Pin 403004, India
    Mar Drugs 8:1417-68. 2010
    ..Though the number of bacterial associates outnumber the fungal associates, the documented potential of fungi to produce clinically active compounds is currently more important than that of bacteria...
  92. ncbi Meta-analyses of the associations of respiratory health effects with dampness and mold in homes
    W J Fisk
    Environmental Energy Technologies Division, Indoor Environment Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Indoor Air 17:284-96. 2007
    ..2. Based on the results of the meta-analyses, building dampness and mold are associated with approximately 30-50% increases in a variety of respiratory and asthma-related health outcomes...
  93. ncbi The Wilhelmine E. Key 1989 invitational lecture. Organization and regulation of the qa (quinic acid) genes in Neurospora crassa and other fungi
    N H Giles
    Department of Genetics, University of Georgia, Athens
    J Hered 82:1-7. 1991
    ..Indirect evidence suggests that the repressor is not a DNA-binding protein but forms an inactive complex with the activator in the absence of the inducer.(ABSTRACT TRUNCATED AT 250 WORDS)..
  94. ncbi Host-microbe interactions: innate pattern recognition of fungal pathogens
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Opin Microbiol 11:305-12. 2008
    The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular ..
  95. pmc Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis
    Dong Chan Oh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Chem Biol 5:391-3. 2009
    ....
  96. ncbi Competition between unit-restricted fungi: a metapopulation model
    Sébastien Gourbière
    Laboratoire de Théorie des Systèmes, Universite de Perpignan, 52 Avenue de Villeneuve, 66860 Perpignan Cedex, France
    J Theor Biol 217:351-68. 2002
    We aimed to provide a theoretical framework for dynamic studies of competition between fungi living on divided and ephemeral resources...
  97. pmc The evolutionary biology and population genetics underlying fungal strain typing
    J W Taylor
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    Clin Microbiol Rev 12:126-46. 1999
    Strain typing of medically important fungi and fungal population genetics have been stimulated by new methods of tapping DNA variation...
  98. pmc Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    T C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle Biomedical Research Institute, Washington, USA
    Clin Microbiol Rev 11:382-402. 1998
    ..Since the study of antifungal drug resistance is relatively new, other factors that may also contribute to resistance are discussed...
  99. ncbi Microbial lipases form versatile tools for biotechnology
    K E Jaeger
    Lehrstuhl Biologie der Mikroorganismen, Ruhr Universitat, Bochum, Germany
    Trends Biotechnol 16:396-403. 1998
    Lipases are secreted into the culture medium by many bacteria and fungi. They catalyse not only the hydrolysis but also the synthesis of long-chain acylglycerols...
  100. pmc Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
    Shengli Xu
    Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
    J Biol Chem 284:7038-46. 2009
    Dectin-1 is a C-type lectin that recognizes beta-glucan in the cell walls of fungi and plays an important role in anti-fungal immunity...
  101. ncbi New tools for the genetic manipulation of filamentous fungi
    Ulrich Kück
    Christian Doppler Laboratory for Fungal Biotechnology, Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Appl Microbiol Biotechnol 86:51-62. 2010
    Filamentous fungi have a long-standing tradition as industrial producers of primary and secondary metabolites...

Research Grants75

  1. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..system evolved over 700 million years to protect uni- and multi- cellular organisms from infection with bacteria, fungi, viruses and other pathogens...
  2. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Immune cells sense pathogens such as bacteria, fungi and viruses through a complex array of cellular receptors...
  3. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..Aflatoxins are produced by the fungi Aspergillus, which can contaminate corn, wheat, soy beans, sorghum, peanuts, almonds, and milk. They affect 4...
  4. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..coli, E. faecalis, S. mutans and C. albicans}, generalizes to other genera, species and strains of bacteria and fungi. {We will characterize adverse effects (if any) associated with delivery of electrical current in our animal model ..
  5. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2012
    ..Furthermore, filamentous fungi are excellent models for asymmetric cell division in animals and Neurospora is the best-characterized microbial ..
  6. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..Despite the growing prevalence of severe fungal infections, no vaccines against fungi are in clinical trials or commercially available...
  7. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..In aim 4 in response to the reviewers'criticisms we will study selectivity for killing microbial cells (both fungi and bacteria) over mammalian skin cells (both mouse and human) and look at possible damage in tissue removed from ..
  8. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011
    ..and respirators are intended to reduce the wearer's exposure to small airborne particles including bacteria, fungi, and viruses...
  9. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
    ..Beta-glucans (BG) are carbohydrates found in the cell wall of fungi (including Pneumocystis) which modulate both the innate and adaptive immune systems and are potentially excellent ..
  10. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..genomic database to permit high throughput, rapid and sensitive identification of microbes (bacteria, viruses, fungi) in original, complex human or animal specimens including respiratory secretions and feces...
  11. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..RELEVANCE: These studies focus on the human fungal pathogens Cryptococcus neoformans and Cryptococcus gattii, fungi that infect the lungs and brain to cause life-threatening pneumonia and meningitis. C...
  12. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..Because fungi are eukaryotic cells, development of antifungal therapeutic compounds that are non-toxic to humans is challenging...
  13. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..The biosynthesis, mechanistic enzymology and molecular genetics of terpenoid biosynthesis in bacteria and fungi will be investigated, with particular emphasis on the mechanistic and structural characterization of three broad ..
  14. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..Fungal keratitis is predominantly caused by filamentous fungi Fusarium, but yeasts (e.g. Candida) can also cause this disease...
  15. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2013
    ..TLRs are a family of pattern recognition receptors that recognize structural components shared by bacteria, fungi and viruses...
  16. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..that mutation of genes involved in the last steps of the GlcCer pathway affect fungal pathogenesis not only of fungi infecting humans, such as Cn3, 4, Candida albicans5-7, and Aspergillus fumigatus8, but also of fungi infecting ..
  17. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..These diseases can be caused by viruses, bacteria, fungi and parasites...
  18. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..They are found in bacteria, fungi, plants and animals...
  19. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..The magnitude of NID caused by fungi is reflected in patient costs...
  20. Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial
    DAVID LARWOOD; Fiscal Year: 2010
    ..The fungi that cause Valley Fever are potential agents of bioterrorism...
  21. Assembly and Maintenance of Centromeres in Filamentous Fungi
    Michael Freitag; Fiscal Year: 2013
    ..epigenetic modifications is difficult to separate in most species. Here, two filamentous fungi, Neurospora crassa and Fusarium graminearum, are used as powerful systems to test the importance of DNA sequence ..
  22. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    ..irritants, since it is present in the exoskeleton of arthropods, the shells of crustaceans, and the cell wall of fungi. Chitin, which is the second most abundant polymer on our planet, is a linear polymer of N- acetylglucosamine...
  23. Centromere Structure and Function in Candida albicans
    Judith G Berman; Fiscal Year: 2012
    ..work is critical for the development of two types of potential therapies directed at centromeres: drugs that kill fungi by directly targeting essential fungal centromere components that differ from those in the human centromere;and ..
  24. Genetic and Evolutionary Basis of Fungal Drug Resistance
    Zhenglong Gu; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Drug resistance of pathogenic fungi is a global health threat, especially among immunocompromised populations such as patients with AIDS, or ..
  25. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2011
    ..TLRs are a family of pattern recognition receptors that recognize structural components shared by bacteria, fungi and viruses...
  26. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..Our preliminary data show that MT in HIV+ adults occurs both from bacteria and also from fungi, an entirely novel observation...
  27. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    ..molecules targeting fungal calcineurin (FC) have extremely potent antifungal activity against a broad range of fungi. Over the past decade, our collaborator has established that calcineurin is required for A...
  28. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..its microbes are represented by non- invasive commensals, the intestine is also a target for parasites, viruses, fungi and pathogenic bacteria...
  29. RNA CONFORMATION AND CATALYSIS
    David P Bartel; Fiscal Year: 2013
    ..of this proposal focus on the phenomenon known as "RNA interference," which protects animals, plants, and fungi from viruses and genomic parasites...
  30. Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHv1
    Susan M E Smith; Fiscal Year: 2013
    ..ROS produced by NADPH oxidase in white blood cells help kill bacteria, fungi, parasites, and other microbial invaders...
  31. Novel Approach to Oral Gene Therapy for Chronic Granulomatous Disease
    Peter E Newburger; Fiscal Year: 2010
    ..primary immunodeficiency disorder characterized by severe recurrent infections by catalase positive bacteria and fungi. The molecular defects causing CGD result in the absence, low expression, or malfunction of one of the phagocyte ..
  32. 2011 Cell-Cell Fusion Gordon Research Conference and Seminar
    NANCY RYAN GRAY; Fiscal Year: 2011
    ..g., fungi, flies, worms, and mice), and single-molecule biophysical methods...
  33. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..To establish the potential value of modified fungi we will use the sphere to assess the efficacy, survivability, and environmental risk posed by pathogens engineered ..
  34. The Hig1 protein family and the cytochrome c oxidase complex
    Rosemary A Stuart; Fiscal Year: 2012
    ..Hig1 family members are found bacteria through eukaryotes, where they show widespread conservation through plants, fungi and animals, indicating their potential importance...
  35. Development and validation of a chitin assay for environmental samples
    CHRISTINE ANNE ROGERS; Fiscal Year: 2012
    ..and is a structural component of common indoor organisms such as dust mites, cockroaches, and fungi that are known asthma triggers. Chitin will be common in the environment where these organisms are abundant...
  36. Regulation of an Iron Import Facilitator by Transcriptional Interference
    CAMILLE REYES NERY; Fiscal Year: 2010
    ..it could identify regulatory paradigms and novel regulatory proteins, which might be conserved in pathogenic fungi or mammalian iron homeostasis...
  37. 2011 Cold Spring Harbor Conference on Telomeres and Telomerase
    David J Stewart; Fiscal Year: 2010
    ..that use a large number of different model organisms (mammals, flies, plants, nematodes, fungi and protozoa)...
  38. Pneumocystis carinii: Macrophage &Epithelial Activation
    Andrew H Limper; Fiscal Year: 2013
    ..studies have focused on unfractionated cell wall ?- glucans or on ?-1,3 glucans during inflammatory responses to fungi. However, recent studies strongly indicate that actually the ?-1,6 glucan exposed side chains of fungal cell walls ..
  39. Identifying novel anti-infectives by high through-put screening in whole animals
    Frederick M Ausubel; Fiscal Year: 2013
    ..Our approach is applicable to many different classes of microorganisms, including bacteria, viruses, fungi and parasites...
  40. Investigation of the structure and function of urea amidolyase
    MARTIN RAOUL ST. MAURICE; Fiscal Year: 2012
    ..Since UAL is found only in a subset of bacteria and fungi, it represents a promising and specific target to combat Candida infections...
  41. Targeting copper homeostasis in the fungal pathogen, Cryptococcus neoformans
    RICHARD FESTA; Fiscal Year: 2013
    ..Copper (Cu) serves as an essential co-factor for a wide variety of enzymes in fungi and humans, but excess Cu is toxic requiring organisms to maintain tight control of intracellular Cu levels...
  42. Bioactive lipids in food and pharmaceutical products
    Eric J Haas-Stapleton; Fiscal Year: 2013
    ..At least two fungi that are pathogenic to humans also produce PGE2, which is thought to potentiate their invasive properties in ..
  43. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..I effort is to build and test a proof-of-concept cell-sorting method, Fountain Flow" Sorting, for the detection of fungi in blood...
  44. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    ..They have been implicated in a variety of physiological processes in plants and fungi, including lignin synthesis and degradation, morphogenesis, pigmentation, detoxification, and virulence...
  45. Innate immune signal transduction specificity in inflammatory disease
    Derek W Abbott; Fiscal Year: 2013
    ..Lay Summary As humans, we are constantly exposed to bacteria, fungi and viruses, and we must respond to these pathogens so that we do not become infected...
  46. Illumina Sequencer to Facilitate Functional Genomics at Berkeley
    John W Taylor; Fiscal Year: 2010
    ..Analyzed samples have come from multiple species of bacteria, protists, plants, fungi and animals, including both model and non-model systems, mouse and human stem cells, and normal and diseased human ..
  47. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    ..We are also relating this work to studies on proteins used to recognize or detoxify heavy metals in bacteria, fungi and humans (e.g., assessing how HgII interacts with the human copper chaperone HAH1).
  48. Mechanisms of Anti-fungal Vaccine Immunity
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..Our work tackles an unmet need: developing and understanding vaccines against fungi. It breaks new ground about anti-fungal memory immunity in CD4 deficient hosts, the role of Tc17 cells, and how ..
  49. N-acetylglucosamine signaling in fungi
    James B Konopka; Fiscal Year: 2012
    ..is a core constituent of extracellular polymers, such as keratin or hyaluronan in humans and cell wall chitin in fungi and parasites...
  50. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ..Develop a quantitative read-out of drug activity, c. Evaluate the MIC of "hit" compounds against a variety of fungi, d. Evaluate the toxicity of compounds against mammalian cells, e. Prioritize compounds, and, f...
  51. Inhibition of Anthrax Lethal Factor by alpha-defensins
    Wuyuan Lu; Fiscal Year: 2011
    ..of a growing family of small cationic antimicrobial peptides that kill a broad range of microbes such as bacteria, fungi and viruses, playing an important role in the innate immune defense against infectious pathogens...
  52. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..Pneumocystis organisms represent a large group of species of atypical fungi with universal distribution,each with specificity for a specific mammalian host...
  53. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony P Bretscher; Fiscal Year: 2013
    ..The myosin-V family of molecular motors is evolutionarily highly conserved between animals, plants and fungi, and defects in vertebrate myosin-Vs can cause disease...
  54. Oxidative and nitrosative stress resistance of Cryptococcus neoformans
    Jennifer K Lodge; Fiscal Year: 2010
    ..Our hypothesis is that C. neoformans (and potentially other fungi) has co-opted a unbiquitous, conserved antioxidant system that is used by other organisms to counteract internally ..
  55. Novel antifungals for Immunocompromised/HIV patients.
    ESTEBAN EDWARD MENA; Fiscal Year: 2011
    ..glucan synthesis inhibitors (including pnemoncandins, other echinocandins) have been found in a diverse range of fungi. These compounds have come from fermentation broths of soil samples cultured in sterile conditions...
  56. Control and Function of Histone H3 Lysine 27 Methylation in Neurospora
    Eric U Selker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Normal development of animals, plants and fungi rely heavily on chromatin-based signals...
  57. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..This knowledge gap is a barrier to disease prevention strategies since Th17 cells promote vaccine immunity to fungi. We hypothesize that Ag-specific CD4+ T cells that protect against dimorphic fungi - Blastomyces, Histoplasma, and ..
  58. The Epidemiology of Home Allergens and Asthma
    Diane R Gold; Fiscal Year: 2010
    ..Endotoxin was correlated with other microbial flora (e.g., muramic acid, a marker for gram + bacteria, fungi);it may be a marker for an array of exposures recognized by antigen presenting cells (APCs) as pathogen-associated-..
  59. Identification of broad-spectrum antifungal efflux pump inhibitors
    Richard Cannon; Fiscal Year: 2009
    ..will be applicable to the panel of yeast strains expressing efflux pumps from the following clinically relevant fungi: Candida albicans, Candida glabrata, Candida krusei and Cryptococcus neoformans...
  60. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger W Innes; Fiscal Year: 2013
    ..As the majority of autophagy genes are conserved between plants, fungi and animals, these experiments will illuminate our understanding of how autophagy is regulated in humans, a ..
  61. Pathogenesis of Cryptococcus Spores
    Christina M Hull; Fiscal Year: 2013
    ..b>Fungi are emerging pathogens, and morbidity and mortality are most apparent among the immunocompromised, especially in ..
  62. Genetic Approaches to Lipid Metabolism
    John E Cronan; Fiscal Year: 2013
    ..acids of medium chain length which trigger breakdown of the biofilms formed by diverse bacteria and some fungi. Prior work demonstrated how the Burkholderia cenocepacia DSF is synthesized, but that enzyme is not fully ..
  63. Development of novel therapeutics for a neglected tropical disease leishmaniasis
    ABHAY R contact SATOSKAR; Fiscal Year: 2010
    ..andrieuxii and from fungi from Mycosynthetix Inc...
  64. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    b>Fungi may respond to the stress of antifungal chemotherapy in specific ways that ultimately reduce the efficacy of the therapy. This "antifungal response" would be analogous to, but mechanistically distinct from, the heat shock response...
  65. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..additives to provide biocidal effects against bacteria (including drug-resistant species), mold and other fungi species, viruses, and spores. An N-halamine is a compound containing one or more nitrogen-halogen covalent bonds...
  66. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Cryptococcus and the Zygomycoses...
  67. Biosynthesis of HSAF, an antifungal natural product with a novel mode of action
    Liangcheng Du; Fiscal Year: 2009
    ..Aspergillus fumigatus, and shows a novel mode of action by disrupting the polarized growth of filamentous fungi. The antifungal activity of HSAF is mediated through a distinct ceramide synthase that is only found in the ..
  68. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    The objective of this proposal is to increase our understanding of the ways in which fungi or other organisms that can colonize patients contribute to diseases of the respiratory tract...
  69. Allosteric DNAzyme sensors for practical detection of mycotoxins
    SCOTT SILVERMAN; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Mycotoxins are toxic compounds produced by fungi that contaminate crops during growth, transportation, or storage...
  70. Antifungal drugs: Beta(1,6)-glucan synthesis inhibitors
    Claude Selitrennikoff; Fiscal Year: 2003
    b>Fungi cause a wide spectrum of disease states. The most common examples are relatively minor, localized infections of the skin and mucous membranes such as athlete's foot, vaginal yeast infections, and infections of keratinized nails...
  71. The glyoxylate cycle as a new target for antifungals
    Claude Selitrennikoff; Fiscal Year: 2003
    b>Fungi cause a wide spectrum of disease states. The most common examples are relatively minor, localized infections of the skin and mucous membranes such as athlete's foot, vaginal yeast infections, and infections of keratinized nails...
  72. Cell wall biogenesis in Cryptococcus neoformans
    Deborah Fox; Fiscal Year: 2004
    ..of the echinocandin class of antifungal agents are potent inhibitors of cell wall synthesis in many pathogenic fungi. However, they have very low potency against Cryptococcus neoformans, a medically significant fungal pathogen...
  73. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Moreover, even in sensitive fungi azoles generally lack fungicidal activity, and consequently recurrences are common...
  74. The presence of a bacterial metabolic pathway in eukaryotic fungi
    KERRY SCOT SMITH; Fiscal Year: 2010
    ..ACK) and xylulose 5- phosphate/fructose 6-phosphate phosphoketolase (XFP) has been identified in eukaryotic fungi. In bacteria, ACK primarily functions with its partner enzyme phosphotransacetylase (PTA) for the interconversion ..
  75. Biological Production of Podophyllotoxin for Sustained Cancer Drug Development
    John Porter; Fiscal Year: 2009
    ..We have identified two fungi endophytic in Podophyllum peltatum, a North American source of the compound that are capable of biosynthesis of ..