spores

Summary

Summary: The reproductive elements of lower organisms, such as BACTERIA; PROTOZOA; FUNGI; and cryptogamic plants.

Top Publications

  1. ncbi Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group
    R Weber
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30333
    N Engl J Med 326:161-6. 1992
  2. ncbi [Prevalence of Enterocytozoon bieneusi spores in the stool of AIDS patients and African children not infected by HIV]
    S Bretagne
    Laboratoire de Parasitologie, Hopital Henri Mondor, Creteil, France
    Bull Soc Pathol Exot 86:351-7. 1993
  3. ncbi Effect of crop growth and canopy filtration on the dynamics of plant disease epidemics spread by aerially dispersed spores
    F J Ferrandino
    Department of Plant Pathology and Ecology, The Connecticut Agricultural Experiment Station, P O Box 1106, New Haven 06504, USA
    Phytopathology 98:492-503. 2008
  4. pmc A Phytophthora sojae G-protein alpha subunit is involved in chemotaxis to soybean isoflavones
    Chenlei Hua
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Eukaryot Cell 7:2133-40. 2008
  5. ncbi Tetracapsuloides bryosalmonae (Myxozoa: Malacosporea) portal of entry into the fish host
    D S Grabner
    Fish Medicine and Livestock Management, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    Dis Aquat Organ 90:197-206. 2010
  6. ncbi Cell-to-cell communication across the prokaryote-eukaryote boundary
    Ian Joint
    Plymouth Marine Laboratory, Prospect Place, Plymouth, PL1 3DH, UK
    Science 298:1207. 2002
  7. pmc A strategy for the proliferation of Ulva prolifera, main causative species of green tides, with formation of sporangia by fragmentation
    Shan Gao
    College of Marine Science and Engineering, Tianjin University of Science and Technology, Tianjin, China
    PLoS ONE 5:e8571. 2010
  8. ncbi Analysis of the action of compounds that inhibit the germination of spores of Bacillus species
    D E Cortezzo
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06032 3305, USA
    J Appl Microbiol 96:725-41. 2004
  9. ncbi [Microsporidian spores in the stool specimens of toddlers, with or without diarrhea, from Tucumán, Argentina]
    S M Valperga
    Catedra de Parasitologia, Facultad de Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Argentina
    Rev Argent Microbiol 31:157-64. 1999
  10. ncbi Rapid attachment of spores of the fouling alga Ulva fasciata on biofilms
    Hyun Woung Shin
    Department of Marine Biotechnology, Soonchunhyang University, Asan City 336 745, South Korea
    J Environ Biol 29:613-9. 2008

Research Grants

  1. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
  2. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
  3. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
  4. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
  5. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
  6. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
  7. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
  8. Immunobiology of Bacillus anthracis Spore-Host Interactions
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2012
  9. Biomarker Prediction of Gleason Upgrading
    Bruce J Trock; Fiscal Year: 2010
  10. Factors for Epigenetic Silencing of Lung Cancer Genes
    Steven A Belinsky; Fiscal Year: 2013

Detail Information

Publications234 found, 100 shown here

  1. ncbi Improved light-microscopical detection of microsporidia spores in stool and duodenal aspirates. The Enteric Opportunistic Infections Working Group
    R Weber
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30333
    N Engl J Med 326:161-6. 1992
    ..We have developed a new method to detect microsporidia spores in feces and duodenal aspirates.
  2. ncbi [Prevalence of Enterocytozoon bieneusi spores in the stool of AIDS patients and African children not infected by HIV]
    S Bretagne
    Laboratoire de Parasitologie, Hopital Henri Mondor, Creteil, France
    Bull Soc Pathol Exot 86:351-7. 1993
    ..E. bieneusi spores were searched for in stool smears of two populations using a modified chromotrope 2R staining...
  3. ncbi Effect of crop growth and canopy filtration on the dynamics of plant disease epidemics spread by aerially dispersed spores
    F J Ferrandino
    Department of Plant Pathology and Ecology, The Connecticut Agricultural Experiment Station, P O Box 1106, New Haven 06504, USA
    Phytopathology 98:492-503. 2008
    ..The effects that these crop growth-related factors have on plant disease epidemics spread by airborne spores are evaluated using mathematical models and their importance is discussed...
  4. pmc A Phytophthora sojae G-protein alpha subunit is involved in chemotaxis to soybean isoflavones
    Chenlei Hua
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Eukaryot Cell 7:2133-40. 2008
    ....
  5. ncbi Tetracapsuloides bryosalmonae (Myxozoa: Malacosporea) portal of entry into the fish host
    D S Grabner
    Fish Medicine and Livestock Management, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    Dis Aquat Organ 90:197-206. 2010
    ..In the present study, spores of T...
  6. ncbi Cell-to-cell communication across the prokaryote-eukaryote boundary
    Ian Joint
    Plymouth Marine Laboratory, Prospect Place, Plymouth, PL1 3DH, UK
    Science 298:1207. 2002
  7. pmc A strategy for the proliferation of Ulva prolifera, main causative species of green tides, with formation of sporangia by fragmentation
    Shan Gao
    College of Marine Science and Engineering, Tianjin University of Science and Technology, Tianjin, China
    PLoS ONE 5:e8571. 2010
    ..prolifera, changes of the photosynthetic properties of cells during sporangia formation, and development of spores. The results suggested that disks less than 1...
  8. ncbi Analysis of the action of compounds that inhibit the germination of spores of Bacillus species
    D E Cortezzo
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06032 3305, USA
    J Appl Microbiol 96:725-41. 2004
    To determine the mechanism of action of inhibitors of the germination of spores of Bacillus species, and where these inhibitors act in the germination process.
  9. ncbi [Microsporidian spores in the stool specimens of toddlers, with or without diarrhea, from Tucumán, Argentina]
    S M Valperga
    Catedra de Parasitologia, Facultad de Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Argentina
    Rev Argent Microbiol 31:157-64. 1999
    An investigation has been carried out from September 1995 to December 1997 to search for microsporidian spores in the stool specimens of 344 toddlers aged 1 to 24 months, hospitalized at a pediatric institution in Tucumán...
  10. ncbi Rapid attachment of spores of the fouling alga Ulva fasciata on biofilms
    Hyun Woung Shin
    Department of Marine Biotechnology, Soonchunhyang University, Asan City 336 745, South Korea
    J Environ Biol 29:613-9. 2008
    Attachment of spores of Ulva fasciata to natural biofilms was examined to probe the basis for specificity in settlement...
  11. ncbi Monitoring of Alternaria Ness and Cladosporium Link airborne spores in Lublin (Poland) in 2002
    Aleksandra Konopińska
    Department of Botany, Agricultural University of Lublin, Akademicka 15, 20 950 Lublin, Poland
    Ann Agric Environ Med 11:347-9. 2004
    The concentration of Alternaria and Cladosporium spores was monitored throughout the year 2002 in Lublin (Eastern Poland). Fungal spores were sampled with Lanzoni VPPS 2000 volumetric spore trap...
  12. ncbi Leptotheca sparidarum n. sp. (Myxosporea: Bivalvulida), a parasite from cultured common dentex (Dentex dentex L.) and gilthead sea bream (Sparus aurata L.) (Teleostei: Sparidae)
    A Sitja-Bobadilla
    Instituto de Acuicultura de Torre de la Sal CSIC, Castellon, Spain
    J Eukaryot Microbiol 48:627-39. 2001
    ..It is distinguished from all the previously described species by spore morphometrics. Spores with two equal polar capsules and one binucleated sporoplasm. Spore measurements from D. dentex were 5-7...
  13. ncbi [Effects of Gadol and Ganoderma spores on the adiponectin signal pathway in hypertrophic myocardium of spontaneous hypertensive rats]
    Zhi Guo Zhang
    Department of Physiology and Pathophysiology, Health Science Center of Peking University, Beijing
    Zhongguo Zhong Xi Yi Jie He Za Zhi 29:233-7. 2009
    ..the adiponectin signal pathway in hypertrophic myocardium of spontaneous hypertensive rats (SHR) and to observe the effects of Gadol (GD) and Ganoderma spores (GS) on the hemodynamic parameters and the adiponectin signal pathway of SHR.
  14. ncbi Indication of global deforestation at the Cretaceous-Tertiary boundary by New Zealand fern spike
    V Vajda
    Department of Geology, Lund University, Tornavägen 13, SE 223 63 Lund, Sweden
    Science 294:1700-2. 2001
    ..Recovery of New Zealand plant communities followed a pattern consistent with major climatic perturbations occurring after an impact winter that was possibly preceded by global wildfires...
  15. pmc PCR-based method using propidium monoazide to distinguish viable from nonviable Bacillus subtilis spores
    H Rawsthorne
    Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, 400 Dan Allen Drive, Raleigh, NC 27695 7624, USA
    Appl Environ Microbiol 75:2936-9. 2009
    ..describes a molecular-based method which is able to discriminate between viable and inactivated Bacillus subtilis spores by utilizing the DNA-intercalating dye propidium monoazide...
  16. ncbi A data analysis of the irradiation parameter D10 for bacteria and spores under various conditions
    S J van Gerwen
    Wageningen Agricultural University, Department of Food Technology and Nutritional Sciences, The Netherlands
    J Food Prot 62:1024-32. 1999
    ..The best first step appeared to be a classification of the data into vegetative bacteria and spores. As expected, spores were found to have significantly higher D10 values (average 2...
  17. ncbi Fungal proliferation at the Cretaceous-Tertiary boundary
    Vivi Vajda
    GeoBiosphere Science Centre, Lund University, Sölvegatan 12, SE 223 62, Lund, Sweden
    Science 303:1489. 2004
  18. ncbi Ultrastructure of Enteromyxum leei (Diamant, Lom, & Dyková, 1994) (Myxozoa), an enteric parasite infecting gilthead sea bream (Sparus aurata) and sharpsnout sea bream (Diplodus puntazzo)
    Montse Cuadrado
    Facultat de Veterinària UAB, Bellaterra, Barcelona, Spain
    J Eukaryot Microbiol 55:178-84. 2008
    ..Within sporogonic stages, nonsporogonic secondary cells were observed accompanying two developing spores. Mature spores had a binucleated sporoplasm in which glycogen stores were abundant and no sporoplasmosomes were ..
  19. ncbi Isolation and analysis of bacteria associated with spores of Gigaspora margarita
    A F Cruz
    Graduate School of Agriculture, Kyoto Prefectural University, Sakyo ku, Kyoto, Japan
    J Appl Microbiol 104:1711-7. 2008
    The aim of this work was to observe bacteria associated with the spores of Gigaspora margarita, an arbuscular mycorrhizal fungus (AMF).
  20. pmc Kinetics of germination of wet-heat-treated individual spores of Bacillus species, monitored by Raman spectroscopy and differential interference contrast microscopy
    Guiwen Wang
    Department of Physics, East Carolina University, Greenville, NC 27858 4353, USA
    Appl Environ Microbiol 77:3368-79. 2011
    ..monitor the kinetics of nutrient and nonnutrient germination of multiple individual untreated and wet-heat-treated spores of Bacillus cereus and Bacillus megaterium, as well as of several isogenic Bacillus subtilis strains...
  21. pmc Tracking taphonomic regimes using chemical and mechanical damage of pollen and spores: an example from the Triassic-Jurassic mass extinction
    Luke Mander
    Department of Plant Biology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 7:e49153. 2012
    ..Taken together, our results suggest that the patterns of vegetation change at Astartekløft represent a real biological response to environmental change at the Tr-J...
  22. pmc Detection of microsporidial spores in fecal specimens from patients diagnosed with cryptosporidiosis
    L S Garcia
    Department of Pathology, UCLA Medical Center 90024 1713
    J Clin Microbiol 32:1739-41. 1994
    ..parvum only, 25 (42%) with microsporidia only, and 17 (28%) with both C. parvum and microsporidia. These findings emphasize the importance of considering both organisms as potential causative agents of diarrhea in compromised patients...
  23. ncbi Direct transformation of the liverwort Marchantia polymorpha L. by particle bombardment using immature thalli developing from spores
    Shota Chiyoda
    Graduate School of Biostudies, Kyoto University, Kyoto, 606 8502, Japan
    Plant Cell Rep 27:1467-73. 2008
    ..Here we report an improved direct transformation system of M. polymorpha using immature thalli developing from spores. Hygromycin-resistant transformants were obtained on selective media by transformation with a plasmid carrying the ..
  24. pmc Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome
    Laura Baxter
    School of Life Sciences, Warwick University, Wellesbourne, CV35 9EF, UK
    Science 330:1549-51. 2010
    ..These attributes comprise a genomic signature of evolution toward obligate biotrophy...
  25. ncbi A new and improved "quick-hot Gram-chromotrope" technique that differentially stains microsporidian spores in clinical samples, including paraffin-embedded tissue sections
    H Moura
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Arch Pathol Lab Med 121:888-93. 1997
    ..This report describes a new and improved "quick-hot Gram-chromotrope" staining technique that detects microsporidian spores in clinical specimens, such as stool, urine, saliva, nasopharyngeal fluid, and bronchoalveolar lavage samples, as ..
  26. pmc Development and application of a new method for specific and sensitive enumeration of spores of nonproteolytic Clostridium botulinum types B, E, and F in foods and food materials
    Michael W Peck
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Appl Environ Microbiol 76:6607-14. 2010
    ..a selective enrichment culture with multiplex PCR has been developed and validated to enumerate specifically the spores of nonproteolytic C. botulinum...
  27. ncbi Photocatalytic oxidation of bacteria, bacterial and fungal spores, and model biofilm components to carbon dioxide on titanium dioxide-coated surfaces
    Edward J Wolfrum
    National Renewable Energy Laboratory, Golden, Colorado 80401, USA
    Environ Sci Technol 36:3412-9. 2002
    We report carbon mass balance and kinetic data for the total oxidation of cells, spores, and biomolecules deposited on illuminated titanium dioxide surfaces in contact with air...
  28. pmc Novel localization of callose in the spores of Physcomitrella patens and phylogenomics of the callose synthase gene family
    Scott Schuette
    Department of Plant Biology 6509, Southern Illinois University, Carbondale, IL 62901, USA
    Ann Bot 103:749-56. 2009
    ..Correlated light, fluorescence and immuno-electron microscopy was conducted on the developing spores of Physcomitrella patens to probe for callose...
  29. ncbi Plant retinoblastoma homologues control nuclear proliferation in the female gametophyte
    Chantal Ebel
    Institute of Plant Sciences, Swiss Federal Institute of Technology, ETH Zurich, Universitatstrasse 2, CH 8092 Zurich, Switzerland
    Nature 429:776-80. 2004
    Haploid spores of plants divide mitotically to form multicellular gametophytes...
  30. ncbi Thunderstorm-related asthma: not only grass pollen and spores
    Gennaro D'Amato
    J Allergy Clin Immunol 121:537-8; author reply 538. 2008
  31. ncbi Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
    ..Because the dried powder of ganoderma is commercially available as a dietary supplement itself, the purpose of this study was to evaluate the biologic activity of samples of Ganoderma lucidum from different sources...
  32. ncbi Study of the antibacterial effects of chitosans on Bacillus cereus (and its spores) by atomic force microscopy imaging and nanoindentation
    João C Fernandes
    Escola Superior de Biotecnologia, Universidade Catolica Portuguesa, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Ultramicroscopy 109:854-60. 2009
    ..eventually led to the death of the vegetative form by preventing the uptake of nutrients yet did not affect the spores since these can survive for extended periods without nutrients...
  33. ncbi Membrane-based on-line optical analysis system for rapid detection of bacteria and spores
    Pierre N Floriano
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA
    Biosens Bioelectron 20:2079-88. 2005
    ..microchip technology towards the development of a new method for detecting and enumerating bacterial cells and spores. This new approach is based on the immuno-localization of bacterial spores captured on a membrane filter microchip ..
  34. ncbi Immunostimulatory activity of Bacillus spores
    Jen Min Huang
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK
    FEMS Immunol Med Microbiol 53:195-203. 2008
    ..subtilis, Bacillus licheniformis and Bacillus flexus to evaluate the nature of interaction between spores and the GALT...
  35. pmc Profile and analysis of gene expression changes during early development in germinating spores of Ceratopteris richardii
    Mari L Salmi
    Molecular Cell and Developmental Biology, University of Texas, Austin, Texas 78751, USA
    Plant Physiol 138:1734-45. 2005
    Analysis of an expressed sequence tag library with more than 5,000 sequences from spores of the fern Ceratopteris richardii reveals that more than 3,900 of them represent distinct genes, and almost 70% of these have significant similarity ..
  36. ncbi Recovery efficiencies of anthrax spores and ricin from nonporous or nonabsorbent and porous or absorbent surfaces by a variety of sampling methods*
    Dody A Frawley
    Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Forensic Sci 53:1102-7. 2008
    ..to be contaminated after the release of environmentally stable bioaggressive agents, as exemplified by anthrax spores and ricin...
  37. ncbi High avidity binding of engineered papaya mosaic virus virus-like particles to resting spores of Plasmodiophora brassicae
    Hélène Morin
    Infectious Disease Research Centre, University Laval, Pav CHUL, CHUQ, 2705 Boulevard Laurier, Quebec, PQ, Canada G1V 4G2
    J Biotechnol 128:423-34. 2007
    ..virus (PapMV) like particles (VLPs) were used as a platform for fusion of affinity peptides binding to resting spores of Plasmodiophora brassicae-a major pathogen of crucifers...
  38. ncbi Spores before sporophytes: hypothesizing the origin of sporogenesis at the algal-plant transition
    Roy C Brown
    Department of Biology, University of Louisiana at Lafayette, Lafayette, LA 70504, USA
    New Phytol 190:875-81. 2011
    Fossil spores from mid-Ordovician deposits (475 million yr old) are the first indication of plants on land and predate megafossils of plants by 30-50 million yr...
  39. pmc Characterization of wet-heat inactivation of single spores of bacillus species by dual-trap Raman spectroscopy and elastic light scattering
    Pengfei Zhang
    Department of Physics, East Carolina University, Greenville, NC 27858 4353, USA
    Appl Environ Microbiol 76:1796-805. 2010
    ..light scattering (ELS) were used to investigate dynamic processes during high-temperature treatment of individual spores of Bacillus cereus, Bacillus megaterium, and Bacillus subtilis in water...
  40. ncbi High levels of actin tyrosine phosphorylation: correlation with the dormant state of Dictyostelium spores
    Y Kishi
    Department of Physics, Rikkyo St Paul s University, Toshima ku, Tokyo, Japan
    J Cell Sci 111:2923-32. 1998
    ..removal of nutrients, the amoebae of the cellular slime mold Dictyostelium discoideum differentiate into dormant spores which survive starvation stress...
  41. ncbi Water properties in fern spores: sorption characteristics relating to water affinity, glassy states, and storage stability
    Daniel Ballesteros
    Banco de Germoplasma, Jardí Botànic ICBiBE, Universitat de Valencia, C Quart, 80, E 46008 Valencia, Spain
    J Exp Bot 58:1185-96. 2007
    Ex situ conservation of ferns may be accomplished by maintaining the viability of stored spores for many years...
  42. ncbi Reproduction diversity of Enteromorpha prolifera
    Apeng Lin
    Life Sciences School, Soochow University, Suzhou, China
    J Integr Plant Biol 50:622-9. 2008
    ..prolifera mainly depends on asexual methods. The results presented here contribute to increasing our understanding about how the opportunistic macroalgae successfully maintain colonization and excessive growth...
  43. pmc The high-resolution architecture and structural dynamics of Bacillus spores
    Marco Plomp
    BioSecurity and NanoSciences Laboratory, Lawrence Livermore National Laboratory, Livermore, California, USA
    Biophys J 88:603-8. 2005
    ..The dimensions of individual Bacillus atrophaeus spores decrease reversibly by 12% in response to a change in the environment from fully hydrated to air-dried state, ..
  44. ncbi Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory
    L J Wheeldon
    Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    J Antimicrob Chemother 62:522-5. 2008
    Persistent contamination of surfaces by spores of Clostridium difficile is a major factor influencing the spread of C. difficile-associated diarrhoea (CDAD) in the clinical setting...
  45. ncbi The spores of Phytophthora: weapons of the plant destroyer
    Howard S Judelson
    Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Nat Rev Microbiol 3:47-58. 2005
    ..These fungus-like eukaryotes, which are taxonomically classified as oomycetes, generate asexual and sexual spores with characteristics that greatly contribute to their pathogenic success...
  46. ncbi Application of PCR and probe hybridization techniques in detection of airborne fungal spores in environmental samples
    Zhihong Wu
    Programme for Chemical Exposure Assessment, National Institute for Working Life, Umea, Sweden
    J Environ Monit 4:673-8. 2002
    ..The detection sensitivity for PCR amplifications was 9 to 73 spores and 1.3 to 19.3 CFUs per PCR reaction. The hybridization detection limit was 2 to 4 spores and 0.2 to 1.2 CFU...
  47. pmc Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin
    Wei Wang
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    J Biol Chem 281:32755-64. 2006
    ..anthracis (Sterne) and rendered their germinating spores nonviable, they also inactivated the enzymatic activity of anthrax lethal factor and protected murine RAW-264...
  48. ncbi A microfluidic cartridge to prepare spores for PCR analysis
    P Belgrader
    Cepheid, Sunnyvale, CA 94089, USA
    Biosens Bioelectron 14:849-52. 2000
    A prototype cartridge system is described that rapidly disrupts Bacillus spores by sonication, adds PCR reagent to the disrupted spores, and dispenses the mixture into a PCR tube...
  49. ncbi During attachment Phytophthora spores secrete proteins containing thrombospondin type 1 repeats
    Andrea V Robold
    Plant Cell Biology Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
    Curr Genet 47:307-15. 2005
    ..In this paper, we report the cloning of a gene, PcVsv1, encoding a protein secreted during attachment of spores of Phytophthora, a genus of highly destructive plant pathogens...
  50. ncbi A Galpha subunit controls zoospore motility and virulence in the potato late blight pathogen Phytophthora infestans
    Maita Latijnhouwers
    Laboratory of Phytopathology, Wageningen University, Binnenhaven, The Netherlands
    Mol Microbiol 51:925-36. 2004
    ..The results prove that PiGPA1 is crucial for zoospore motility and for pathogenicity in an important oomycete plant pathogen...
  51. pmc Nuclear DNA C-values in 30 species double the familial representation in pteridophytes
    Renate Obermayer
    Jodrell Laboratory, Royal Botanic Gardens, Richmond, Surrey, UK
    Ann Bot 90:209-17. 2002
    ..7 pg in Psilotum nudum var. gasa. Superimposing C-value data onto a robust phylogeny of pteridophytes suggests some possible trends in C-value evolution and highlights areas for future work...
  52. ncbi Use of the fluorochrome calcofluor white in the screening of stool specimens for spores of microsporidia
    V A Luna
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle 98195, USA
    Am J Clin Pathol 103:656-9. 1995
    ..Direct detection methods for microsporidial spores in stool include chromotrope-based, fluorochrome, and immunofluorescent stains...
  53. ncbi The effect of filter material on bioaerosol collection of Bacillus subtilis spores used as a Bacillus anthracis simulant
    Nancy Clark Burton
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    J Environ Monit 7:475-80. 2005
    ..In summary, the MCE and 1 microm PTFE filters in combination with vortexing and shaker extraction demonstrated the best performance for the filter collection and extraction of BG spores.
  54. pmc Phosphatidylinositol 3-kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of monospores from the marine red alga Porphyra yezoensis
    Lin Li
    Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato cho, Hakodate 041 8611, Japan
    J Exp Bot 59:3575-86. 2008
    ..Our results also indicate that PI3K-dependent F-actin asymmetry is evolutionally conserved in relation to the establishment of cell polarity in migrating eukaryotic cells...
  55. pmc Aerial dissemination of Clostridium difficile spores
    Katherine Roberts
    Pathogen Control Engineering Research Group, School of Civil Engineering, University of Leeds, Leeds, LS2 9JT, UK
    BMC Infect Dis 8:7. 2008
    ..difficile spores. However previous studies have failed to isolate C. difficile from air in hospitals...
  56. ncbi cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection
    Shweta Saran
    School of Life Sciences, University of Dundee, MSI WTB complex, Dundee DD1 5EH, UK
    J Muscle Res Cell Motil 23:793-802. 2002
    ..We also briefly discuss the two modes of detection of cAMP...
  57. ncbi A regional comparison of mold spore concentrations outdoors and inside "clean" and "mold contaminated" Southern California buildings
    Daniel M Baxter
    Environmental Analysis Associates Inc, San Diego, California 92109, USA
    J Occup Environ Hyg 2:8-18. 2005
    ..In addition, coastal and inland outdoor locations were measured. Seven categories (total spores, Ascospores/Basidiospores, Cladosporium, Smut/Myxomycetes-like, Aspergillus/Penicillium (AS/PE), Alternaria, and ..
  58. ncbi Fungal spores in the atmosphere of Rzeszów (South-East Poland)
    Idalia Kasprzyk
    Institute of Biology and Nature Protection, University of Rzeszow, ul Rejtana 16c, 35 959, Rzeszow, Poland
    Ann Agric Environ Med 11:285-9. 2004
    ..For the analysis, 10 easy to identify fungal spores were chosen from ones regarded as allergenic: Alternaria, Botrytis, Cladosporium, Drechslera (type), Epiccocum, ..
  59. ncbi Nanoscale powders and formulations with biocidal activity toward spores and vegetative cells of bacillus species, viruses, and toxins
    Olga B Koper
    Nanoscale Material, Inc formerly Nantek, Inc, 1500 Hays Drive, Manhattan, KS 66502, USA
    Curr Microbiol 44:49-55. 2002
    ..Likewise, spore forms of the Bacillus species are decontaminated within several hours. Dry contact with aflatoxins and contact with MS2 bacteriophage (surrogate of human enterovirus) in water also causes decontamination in minutes...
  60. ncbi Comparison of the toxicity of reference mycotoxins and spore extracts of common indoor moulds
    Torsten Schulz
    Institute of Microbiology and Hygiene, University of Lubeck, Lubeck, Germany
    Int J Hyg Environ Health 207:267-77. 2004
    ..Only in one extract of disintegrated spores (Aspergillus fumigatus) a mycotoxin (0.22 microg gliotoxin/6.2 x 10(8) spores) was determined...
  61. ncbi An overview on bioaerosols viewed by scanning electron microscopy
    K Wittmaack
    GSF National Research Centre for Environment and Health, Institute of Radiation Protection, 85758 Neuherberg, Germany
    Sci Total Environ 346:244-55. 2005
    ..The observed bioaerosols include brochosomes, fungal spores, hyphae, insect scales, hairs of plants and, less commonly, bacteria and epicuticular wax...
  62. ncbi The spatial and temporal variations in PM10 mass from six UK homes
    K A BeruBe
    School of Biosciences, Cardiff University, P O Box 911, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Sci Total Environ 324:41-53. 2004
    ..The indoor and outdoor PM10 collected was characterised as being a heterogeneous mixture of particles (soot, fibres, sea salt, smelter, gypsum, pollen and fungal spores).
  63. ncbi Abundance of cellular material and proteins in the atmosphere
    Ruprecht Jaenicke
    Institut fur Physik der Atmosphare, Universitat Mainz, 55099 Mainz, Germany
    Science 308:73. 2005
    ..Consequently, the source strength of the biogenic aerosol in general must be corrected and should be estimated on the order of other major aerosol sources...
  64. ncbi Assessment of electrical charge on airborne microorganisms by a new bioaerosol sampling method
    Shu An Lee
    Center for Health Related Aerosol Studies, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
    J Occup Environ Hyg 1:127-38. 2004
    ..First, bacteria, fungal spores, and dust dispersed from soiled carpets were sampled in a walk-in test chamber...
  65. ncbi An unusual appearance of a common pollen type indicates the scene of the crime
    D C Mildenhall
    Institute of Geological and Nuclear Sciences, P O Box 30368, Lower Hutt, New Zealand
    Forensic Sci Int 163:236-40. 2006
    ..Some grains had fungal spores inside...
  66. ncbi Fungal spore source strength tester: laboratory evaluation of a new concept
    Satheesh K Sivasubramani
    Center for Health Related Aerosol Studies, Department of Environmental Health, University of Cincinnati, 3223 Eden Ave, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Sci Total Environ 329:75-86. 2004
    ..In this study, the newly developed fungal spore source strength tester (FSSST), which aerosolizes spores from growth surfaces and samples the airborne fungi into a bioaerosol sampler, was evaluated in the laboratory...
  67. ncbi A comparison of airborne ergosterol, glucan and Air-O-Cell data in relation to physical assessments of mold damage and some other parameters
    M Foto
    Ottawa Carleton Institute of Chemistry, Carleton University, Ottawa, Canada
    Indoor Air 15:257-66. 2005
    ..the majority of airborne glucan found in these houses was fungal in origin arising from both yeasts and intact spores, as well as hyphal and spore fragments...
  68. ncbi Meteorologic variables in aerobiology
    Richard W Weber
    National Jewish Medical and Research Center, 1400 Jackson Street, Room J326, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 23:411-22. 2003
    ..Thunderstorms provide a unique sum of factors that greatly may increase aeroallergen burden. Dispersal of mold spores is linked intimately to precipitation and humidity...
  69. ncbi A method for detecting fungal contaminants in wall cavities
    Joe C Spurgeon
    Bayshore Environmental, Inc, 1349 Montevideo Ave, Placentia, CA 92870, USA
    AIHA J (Fairfax, Va) 64:40-7. 2003
    This article describes a practical method for detecting the presence of both fungal spores and culturable fungi in wall cavities. Culturable fungi were collected in 25 mm cassettes containing 0...
  70. ncbi Asynchronous terrestrial and marine signals of climate change during Heinrich events
    Tim C Jennerjahn
    Zentrum für Marine Tropenökologie, Fahrenheitstrasse 6, D 28359 Bremen, Germany
    Science 306:2236-9. 2004
    ..The inferred time lag of about 1000 to 2000 years is much larger than the ecological response to recent climate change and appears to be related to the nature of hydrological changes...
  71. pmc Wettable and unsinkable: the hydrodynamics of saccate pollen grains in relation to the pollination mechanism in the two New Zealand species of Prumnopitys Phil. (Podocarpaceae)
    Joshua Salter
    School of Biological Sciences, The University of Auckland, New Zealand
    Ann Bot 89:133-44. 2002
    ..ex Endl. (Cephalotaxaceae), Cupressus L. (Cupressaceae) and Phyllocladus Rich. ex Mirb. (Phyllocladaceae), and spores of three fern species and one lycopod species...
  72. ncbi Use of 2n gametes for the production of sexual polyploids from sterile Oriental x Asiatic hybrids of lilies (Lilium)
    R Barba-Gonzalez
    Plant Reserach International, Wageningen University and Research Centre, The Netherlands
    Theor Appl Genet 109:1125-32. 2004
    ..These results indicate that there are effective prospects for combining important horticultural traits from the two main groups of cultivars of lilies through sexual polyploidization...
  73. ncbi Brevibacillus brevis isolated from cadmium- or zinc-contaminated soils improves in vitro spore germination and growth of Glomus mosseae under high Cd or Zn concentrations
    A Vivas
    Departamento de Microbiologia del Suelo y Sistemas Simbioticos, Estacion Experimental del Zaidin, CSIC, Profesor Albareda 1, 18008, Granada, Spain
    Microb Ecol 49:416-24. 2005
    ..brevis reduced the Cd damage on G. mosseae in Cd-contaminated medium. These capabilities of B. brevis isolates partially alleviate the inhibitory effects of Cd or Zn on the axenic growth of G. mosseae...
  74. ncbi Early development of fern gametophytes in microgravity
    Stanley J Roux
    Section of Molecular Cell and Developmental Biology, University of Texas, Austin, TX 78712, USA
    Adv Space Res 31:215-20. 2003
    Dormant spores of the fern Ceratopteris richardii were flown on Shuttle mission STS-93 to evaluate the effects of micro-g on their development and on their pattern of gene expression...
  75. pmc Conserved features of germination and polarized cell growth: a few insights from a pollen-fern spore comparison
    Thomas J Bushart
    Molecular Cell and Developmental Biology, University of Texas, Austin, TX 78751, USA
    Ann Bot 99:9-17. 2007
    BACKGROUND: The germination of both pollen and fern spores results in the emergence of a cell-pollen tube from pollen, rhizoid from spore-that grows in a polar fashion, primarily at its apical end...
  76. pmc A genomewide study of reproductive barriers between allopatric populations of a homosporous fern, Ceratopteris richardii
    Takuya Nakazato
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7005, USA
    Genetics 177:1141-50. 2007
    ....
  77. ncbi Lead tolerance and accumulation in the gametophytes of the fern Athyrium yokoscense
    Hiroyuki Kamachi
    Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama, 930 8555, Japan
    J Plant Res 118:137-45. 2005
    ..Because proanthocyanidins have a latent ability to complex with lead ions, the possible roles of proanthocyanidins in the lead tolerance and accumulation of Athyrium gametophytes are discussed...
  78. ncbi Air quality measurements for the aerosol research and inhalation epidemiology study
    D Alan Hansen
    Electric Power Research Institute, Palo Alto, CA 94304, USA
    J Air Waste Manag Assoc 56:1445-58. 2006
    ..To date, 13-, 25-, and 53-month air quality datasets have been used in epidemiologic analyses...
  79. ncbi Inhibition of Ageratina adenophora on spore germination and gametophyte development of Macrothelypteris torresiana
    Kai Mei Zhang
    Institute of Botany, Chinese Academy of Sciences, Beijing, China
    J Integr Plant Biol 50:559-64. 2008
    ..With the treatment of root leachates, the delay was more obvious. Thus A. adenophora inhibited the spore germination and gametophyte development of M. torresiana and the root leachates were most inhibitory...
  80. ncbi Histopathological and ultrastructural studies of Henneguya suprabranchiae Landsberg, 1987 (Myxosporea: Myxobolidae) parasitizing the suprabranchial organ of the freshwater catfish Clarias gariepinus Burchell, 1822 in Egypt
    A el-Mansy
    National Institute of Oceanography and Fisheries, Aquatic Pathological Laboratory, 101 Kaser El Einii St, Cairo, Egypt
    Parasitol Res 88:617-26. 2002
    ..plasmodia of these parasites contained generative cells with immature pansporoblasts at the periphery and mature spores occupying the center...
  81. ncbi Influence of five organic antifouling candidates on spore attachment and germination of a fouling alga Ulva pertusa
    M Sidharthan
    Department of Marine Biotechnology, Soonchunhyang University, Asan City, South Korea 336 745
    J Environ Biol 28:39-43. 2007
    ..Especially spores of a fouling alga, Ulva pertusa were used in this study to test the AF efficiency of five organic chemicals...
  82. ncbi Comparison of multiple environmental factors for asthmatic children in public housing
    D Brugge
    Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Indoor Air 13:18-27. 2003
    ..We hypothesize that our findings are consistent with a multifactorial model for exacerbation of asthma in this population and that no single problem dominates...
  83. ncbi Indoor air quality, ventilation and health symptoms in schools: an analysis of existing information
    J M Daisey
    Indoor Environment Department, Berkeley, CA 94720, USA
    Indoor Air 13:53-64. 2003
    ..Measurements of airborne bacteria and airborne and surface fungal spores were reported in schoolrooms. Asthma and 'sick building syndrome' symptoms are commonly reported...
  84. ncbi Comparison of biocontaminant levels associated with hard vs. carpet floors in nonproblem schools: results of a year long study
    Karin Foarde
    Microbiology Department, RTI International, Research Triangle Park, NC 27709, USA
    J Expo Anal Environ Epidemiol 14:S41-8. 2004
    ..Significant differences in airborne levels were found for dust mass, spores, fungi, beta-1,3 glucans, and endotoxins...
  85. ncbi MSI-99, a magainin analogue, imparts enhanced disease resistance in transgenic tobacco and banana
    A Chakrabarti
    Nuclear Agriculture and Biotechnology DivisionBhabha Atomic Research Centre, 400085, Trombay, Mumbai, India
    Planta 216:587-96. 2003
    ..The results suggest that MSI-99 can be useful in imparting enhanced disease resistance in transgenic plants...
  86. ncbi Indoor fungal exposure
    Christine A Rogers
    Environmental Science and Engineering Program, Department of Environmental Health, Harvard School of Public Health, Landmark Center, PO Box 15677, 401 Park Drive, Boston, MA 02215, USA
    Immunol Allergy Clin North Am 23:501-18. 2003
    ..Much work is needed in isolating, characterizing and standardizing fungal disease agents to properly assess the prevalence of fungal health effects...
  87. ncbi Airborne viable, non-viable, and allergenic fungi in a rural agricultural area of India: a 2-year study at five outdoor sampling stations
    Atin Adhikari
    Division of Palynology and Environmental Biology, Department of Botany, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata Calcutta 700 009, India
    Sci Total Environ 326:123-41. 2004
    ..The ranges of total fungal spore concentration were 82-2365 spores per cubic meter of air (spores/m3) in the first sampling year and 156-2022 spores/m3 in the second sampling year...
  88. ncbi Comparative performance of impactor air samplers for quantification of fungal contamination
    D Nesa
    Laboratoire de Parasitologie-Mycologie, , France
    J Hosp Infect 47:149-55. 2001
    ....
  89. ncbi Mimicry in plant-parasitic fungi
    Henry K Ngugi
    Department of Plant Pathology, University of Georgia, Athens, GA, USA
    FEMS Microbiol Lett 257:171-6. 2006
    ..g. in some heterothallic rust fungi belonging to the genera Puccinia and Uromyces) or vector infectious spores to healthy plants, thereby spreading disease (e.g...
  90. ncbi Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina
    Yoshiya Seto
    Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Japan
    Biosci Biotechnol Biochem 71:1470-5. 2007
    ..Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC50 value of 22 nM...
  91. ncbi Surface attachment and pre-penetration stage development by plant pathogenic fungi
    S L Tucker
    School of Biological Sciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter, EX4 4QG, United Kingdom
    Annu Rev Phytopathol 39:385-417. 2001
    ..Finally, we anticipate the prospect of genome-level analysis of fungal pathogens and the key research questions that will need to be addressed...
  92. ncbi Characterization of airborne fungal levels after mold remediation
    G T Kleinheinz
    Department of Biology and Microbiology, University of Wisconsin Oshkosh, 800 Algoma Boulevard, Oshkosh, Wisconsin 54901, USA
    Microbiol Res 161:367-76. 2006
    ..This project demonstrates the relationship between mold levels and the success of a mold remediation projects, and will assist in the interpretation of data collected at the conclusion of a mold remediation project...
  93. ncbi Spore release by the green alga Ulva: a quantitative assay to evaluate aquatic toxicants
    Taejun Han
    Division of Biology and Chemistry, University of Incheon, 177 Dohwa dong, Nam Gu, Incheon 402 749, Republic of Korea
    Environ Pollut 153:699-705. 2008
    ..29%) and filtration bed (10.08%), respectively. The bioassay is simple, inexpensive and sensitive. The cosmopolitan distribution of Ulva means that the test would have a potential application worldwide...
  94. ncbi Potential of a novel antibiotic, 2-methylheptyl isonicotinate, as a biocontrol agent against fusarial wilt of crucifers
    Gojen N Bordoloi
    Biochemistry Division, Regional Research Laboratory, Jorhat 785 006, India
    Pest Manag Sci 58:297-302. 2002
    ..Seed treatment with a spore suspension (3 x 10(8) spores ml-1) of the Streptomyces sp 201 displayed protective activity in the range of 56-60%. Seeds coated with 2...
  95. ncbi Agriculture. Taking the bite out of potato blight
    Glenn Garelik
    Science 298:1702-4. 2002
  96. ncbi Does selection by resistant hosts trigger local adaptation in plant-pathogen systems?
    J Montarry
    INRA, UMR BiO3P, Le Rheu Cedex, France
    J Evol Biol 19:522-31. 2006
    ..The data support the hypothesis of general adaptation for aggressiveness, to which directional selection for virulence is superimposed when race-specific resistance is introduced...
  97. ncbi Zoospore encystment and pathogenicity of Phytophthora and Pythium species on plant roots
    Yannis Raftoyannis
    TEI Lamias, Department of Forestry, Karpenisi 36100, Greece
    Microbiol Res 161:1-8. 2006
    ..Correlation analysis between zoospore encystment density and disease severity indicated low and no significant levels (p.05) of association for most plant-oomycete combinations...
  98. ncbi Molecular basis of recognition between phytophthora pathogens and their hosts
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Annu Rev Phytopathol 40:137-67. 2002
    ..One Phytophthora Avr gene, Avr1b from P. sojae, has been cloned and characterized. It encodes a secreted elicitor that triggers a system-wide defense response in soybean plants carrying the cognate R gene, Rps1b...
  99. ncbi Impact of ultraviolet radiation on cell structure, UV-absorbing compounds, photosynthesis, DNA damage, and germination in zoospores of Arctic Saccorhiza dermatodea
    Michael Y Roleda
    Biologische Anstalt Helgoland, Alfred Wegener Institute for Polar and Marine Research, Marine Station, Postfach 180, D 27483 Helgoland, Germany
    J Exp Bot 57:3847-56. 2006
    ..UV-B radiation caused photodestruction indicated by a loss of pigmentation. Photosynthetic efficiency of spores was photoinhibited after 8 h exposure to 22 and 30 mumol photon m(-2) s(-1) of PAR, while supplement of UVR had a ..
  100. ncbi A putative DEAD-box RNA-helicase is required for normal zoospore development in the late blight pathogen Phytophthora infestans
    Claire A Walker
    Aberdeen Oomycete Group, College of Life Science and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Fungal Genet Biol 45:954-62. 2008
    ..These findings indicate that Pi-RNH1 has a major function in zoospore development and its potential role in cytokinesis is discussed...
  101. ncbi Plant-induced cell death in the oomycete pathogen Phytophthora parasitica
    Eric Galiana
    Institut National de la Recherche Agronomique Université Nice Sophia Antipolis Centre National de la Recherche Scientifique, Sophia Antipolis Cedex, France
    Cell Microbiol 7:1365-78. 2005
    ..This characterization of plant-mediated cell death signalling in pathogens will enhance our understanding of the biological processes regulating plant-pathogen interactions, and improve our ability to control crop diseases...

Research Grants77

  1. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..and environmental isolates are a mating type, it had been unclear if sex occurs in nature and how aerosolized spores thought to be infectious propagules arise...
  2. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..could also promote persistence and relapse (a recurrence with the same strain) if it serves as a reservoir for spores, a highly robust, dormant cell type that is resistant to antimicrobial drugs. Understanding how C...
  3. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..available though the UAB Comprehensive Cancer Center and the Center for Human Genetics as well as the four UAB SPORES. A network of extramural consultants and resources, both academic and commercial, also is described...
  4. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..fumigatus spores. In the proposed studies she would further exploit Af3...
  5. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Upon inhalation, the Anthrax spores adhere to the alveolar macrophages and germinate...
  6. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..We plan to engineer recombinant Bacillus subtilis spores that express Ag85B and ESAT-6, to be used as a particulate vaccine to TB...
  7. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    ..Exposure to common environmental allergens along with respiratory allergies to house dust mites, fungal spores, and cockroaches are risk factors in the development of asthma...
  8. Immunobiology of Bacillus anthracis Spore-Host Interactions
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2012
    The use of Bacillus anthracis as a bioweapon depends on dispersal of its spores in the environment, entrance into the body, spore uptake by the human host cells, germination of the spores in the host and the pathological consequences of ..
  9. Biomarker Prediction of Gleason Upgrading
    Bruce J Trock; Fiscal Year: 2010
    ..The IPBS is a prospective collaboration among the 11 SPOREs to evaluate prognostic biomarkers, and also to rigorously evaluate the influence of pre- analytic variability in ..
  10. Factors for Epigenetic Silencing of Lung Cancer Genes
    Steven A Belinsky; Fiscal Year: 2013
    ..for cancer within the National Lung Screening Trial will be conducted through the Johns Hopkins and Colorado Lung SPOREs. Gene methylation assays in sputum will be conducted through our SPORE project with Johns Hopkins and genotyping ..
  11. Role and function of Spx paralogs of Bacillus anthracis
    PETER A ZUBER; Fiscal Year: 2012
    ..The dormant spores are able to escape immune defenses and become engulfed by macrophages, where the spores germinate to generate ..
  12. Inhibition of Anthrax Lethal Factor by alpha-defensins
    Wuyuan Lu; Fiscal Year: 2011
    ..In a subsequent report, Mayer-Scholl et al. (2005) demonstrated that B. anthracis spores engulfed by human neutrophils and germinated intracellularly can be effectively killed by HNPs...
  13. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..provided by applicant): The respiratory immune system clears hundreds of airborne Aspergillus fumigatus spores (conidia) daily...
  14. Structure and Function of the B. anthracis Exosporium
    Charles L Turnbough; Fiscal Year: 2010
    ..B. anthracis is used as a biological weapon primarily because it forms durable spores. These spores can enter the body through multiple routes, germinate, and grow as vegetative cells, which usually ..
  15. Pathogenesis of Cryptococcus Spores
    Christina M Hull; Fiscal Year: 2013
    ..neoformans yeast and the host immune system, but none has evaluated spores, likely infectious particles in nature...
  16. A fully integrated assay and platform for detecting Clostridium difficile
    BRUCE D IRVINE; Fiscal Year: 2010
    ..A sensitive assay that is capable of processing and detecting C. diff spores would substantially protect the health of the patient as well as reduce the risk of spread of CDAD in hospitals, ..
  17. Genetics of the formation of repair &recombination foci
    RODNEY J ROTHSTEIN; Fiscal Year: 2013
    ..the DNA damage response to affect foci both after damage as well as during a unique asymmetric cell division after spores are formed...
  18. Protective Effects of Anti-BclA Antibodies in Bacillus anthracis Infection
    JUAN B RODRIGUEZ BARRANTES; Fiscal Year: 2013
    ..mechanisms that have yet to be completely elucidated include uptake by the human host cells, germination of the spores in the host and the pathological consequences of the host response to the toxins elaborated by the vegetative ..
  19. Anthrax Toxin Lethal Factor Inhibition Study
    Elizabeth A Amin; Fiscal Year: 2012
    ..cell death, and the findings from this work are ultimately expected to guide the design of effective therapeutics that can aid persons who have been, or suspect they may have been, exposed to anthrax spores in an emergency situation.
  20. A synergy-based therapy against C. difficile
    Kim Lewis; Fiscal Year: 2013
    ..Upon reaching stationary state, C. difficile produces spores, which are responsible for the relapse of the infection...
  21. Mayo Comprehensive Cancer Center Grant
    Robert B Diasio; Fiscal Year: 2013
    ..7 million. Of particular note is that, in addition to an increase in investigator-initiated grants, MCCC has 2 new SPOREs (Breast and Brain) and 2 new training grants...
  22. Inexpensive multiplexed ligation probe assay to genotype drug resistant M.tubberc
    HEATHER KOSHINSKY; Fiscal Year: 2012
    ..The steps in the assay would be: (1) addition of an internal process control (such as quantified spores for extraction control) followed by standard sputum treatment and DNA isolation, (2) division of isolated DNA into ..
  23. Exposporium determinants of Bacillus anthracis
    George C Stewart; Fiscal Year: 2013
    ..This exosporium protein binds to receptors on phagocytic cells to promote uptake of the spores and which initiates the infectious process...
  24. Final preclinical development of an immunoadhesin therapy for inhalation anthrax
    KEITH WYCOFF; Fiscal Year: 2013
    Description (provided by the applicant): Inhalational anthrax, caused by inhaled Bacillus anthracis spores, has a ~50% fatality rate even when treated with antibiotics...
  25. Biosynthesis & Function of a Bacillus anthracis-specific cell wall polysaccharide
    Russell W Carlson; Fiscal Year: 2010
    ..anthracis strains, is immunogenic in that animals injected with live or dead spores of B...
  26. Functional Characterization of Rec104 in Meiotic Recombination
    Isabel Lam; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Meiosis is a specialized cell division that generates spores or gametes that are half the genome equivalent of the progenitor cell...
  27. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    Bioterrorism is no longer a threat in the United States, but a reality. In 2001, the spread of anthrax spores through the U.S. mail illustrated that deadly agents can be acquired and spread using relatively unsophisticated means...
  28. HA in fungal allergic asthma
    Jane M Schuh; Fiscal Year: 2013
    ..Because of their ubiquitous nature, fungal spores are nearly impossible to avoid...
  29. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..biocidal effects against bacteria (including drug-resistant species), mold and other fungi species, viruses, and spores. An N-halamine is a compound containing one or more nitrogen-halogen covalent bonds...
  30. Antidotes to Anthrax Lethal Factor Intoxication
    ALAN THOMAS JOHNSON; Fiscal Year: 2012
    ..While exposure to this pathogen is limited in nature, the lethality of anthrax spores when used as a bioterrorism weapon was clearly demonstrated in the 2001 attacks through the US mail...
  31. Phase I clinical trial of an immunoadhesin antitoxin for anthrax
    KEITH WYCOFF; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inhalational anthrax, caused by inhaled Bacillus anthracis spores, has a ~50% fatality rate even when treated with antibiotics...
  32. Spores as a protein display platform for directed evolution of membrane proteins
    Edgardo T Farinas; Fiscal Year: 2012
    ..Bacillus subtilis spores will be developed as a protein display platform for direct or laboratory evolution...
  33. Inhibitors of Anthrax Lethal Factor Metalloproteinase
    Alan Johnson; Fiscal Year: 2009
    ..Although exposure to this pathogen is limited in nature, the lethality of anthrax spores as a bioterrorism weapon was demonstrated in the 2001 attacks through the US mail...
  34. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores.
  35. Novel Therapy for Pulmonary Anthrax
    KEITH WYCOFF; Fiscal Year: 2012
    ..anthracis spores. We have created transgenic tobacco plants that accumulate PBI-220 at commercially useful levels (>75 mg/kg ..
  36. Mucosal live vector vaccine against recurrent Clostridium difficile infections
    James E Galen; Fiscal Year: 2013
    ..difficile antigens will be further tested for protection in mice similarly immunized with he multivalent strain and challenged orogastrically with spores from an epidemic strain of C. difficile.
  37. GENE EXPRESSION DURING SPORULATION
    Patrick J Piggot; Fiscal Year: 2012
    This proposal focuses on how spores are formed by Bacillus subtilis. B. subtilis has become a paradigm for the study of spore formation, and of cell differentiation in prokaryotes, because of the ease of its genetic manipulation...
  38. A novel anti-spore nasal vaccine for protection from anthrax
    Amy Rasley; Fiscal Year: 2013
    ..proteins and test their ability to function as a nasal vaccine protecting mice from a challenge with virulent spores. We have the following specific aims: 1) Generate and analyze a nickel-chelated nanolipoprotein particle (NiNLP) ..
  39. CANCER CENTER SUPPORT GRANT
    Jennifer A Pietenpol; Fiscal Year: 2013
    ..In addition, we successfully renewed all three NCI SPOREs as well as eight multi-investigator and 11 training grants...
  40. Ultrasensitive Detection of Hepatitis Viruses by Immunoassay Amplification
    Boris Rotman; Fiscal Year: 2013
    ..BCR technology exploits phenotypically engineered fluorogenic bacterial spores (F-spores(tm)) as nanodetectors...
  41. Aspergillus-specific CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2010
    ..fumigatus spores, 2) to establish the role of the regulatory cytokines IL-10 and TGFbeta in this process, 3) to examine the ..
  42. Protection Against Inhalation Anthrax with Inactivated Spores
    Donald G Guiney; Fiscal Year: 2012
    ..Partnership is to develop a highly effective immunologic countermeasure to pulmonary infection with anthrax spores. The basic strategy of this application involves the development of a spore-based vaccine that combines killed, ..
  43. The role of TLR9 on Aspergillus fumigatus phagosomes
    Jatin M Vyas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aspergillus fumigatus is a saprophytic filamentous fungus whose asexual spores called conidia are widespread in the environment, acquired through inhalation and small enough to reach the distal ..
  44. A Better High-level Disinfectant for Endoscopes and Other Medical Equipments/Devi
    Neera Satsangi; Fiscal Year: 2012
    ..dioxide under almost neutral conditions, allowing the product to have enough contact time with microbes and spores for proposed HLD action without imparting the corrosiveness encountered with common chlorine dioxide formulations...
  45. Surface Proteins of Bacillus anthracis
    Olaf Schneewind; Fiscal Year: 2013
    ..provided by applicant): Bacillus anthracis is the causative agent of anthrax, a zoonotic disease transmitted by spores that germinate in the infected host. The resulting vegetative forms of B...
  46. SPORE IN LUNG CANCER
    Stephen B Baylin; Fiscal Year: 2013
    ..chemoprevention trials (Lung Cancer Biomarker Chemoprevention Consortium-LCBCC) involving other Lung Cancer SPORES and, especially, the Colorado SPORE...
  47. Investigate the multifunctional adhesins in Cryptococcus
    Xiaorong Lin; Fiscal Year: 2013
    ..Cfl1 is up-regulated during the yeast-to-filament transition and it coats the surface of hyphae and infectious spores generated from hyphae...
  48. In vivo effects of anthrax toxins:imaging host response & bacterial proliferation
    Ian Justin Glomski; Fiscal Year: 2010
    ..We predict that the immune system will initially respond to dormant spores, but will subsequently be impaired when spores germinate and begin secreting toxins...
  49. The role of calcium-DPA in the virulence of Bacillus anthracis spores
    ERNESTO V ABEL-SANTOS; Fiscal Year: 2013
    ..Following the inhalation route, B. anthracis spores are phagocytized by alveolar macrophages where they germinate. Interestingly, B...
  50. Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    William J Steinbach; Fiscal Year: 2010
    ..fumigatus pathogenesis. IA occurs when A. fumigatus spores germinate into invading hyphae...
  51. Phylogenomic epidemiology of Clostridium difficile
    Seth T Walk; Fiscal Year: 2013
    ..of pandemic strains is the overproduction of toxins and an increased ability to form environmentally-resistant spores. However, recent studies that include data from a larger set of representative isolates challenge this hypothesis ..
  52. Microparticle Capture-Based Analysis of Lymph Node Proteome
    Serguei Popov; Fiscal Year: 2013
    ..anthracis. In the case of B. anthracis, the lymphatic system serves as the conduit by which germinating spores are delivered by macrophages to the sentinel lymph nodes (SLNs) within hours after exposure...
  53. Molecular Therapeutics for Anaplastic Gliomas
    G Gillespie; Fiscal Year: 2009
    ..strong institutional commitments from both the University and its Cancer Center, and we fully expect to develop active collaborative interactions with both our institutional SPOREs as well as with other SPOREs nationally.
  54. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Airborne conidia (spores) represent infectious propagules that are responsible for transmission of major human mycoses. Humans inhale ubiquitous Aspergillus fumigatus conidia on a daily basis...
  55. Optimized CYP51 Inhibitors for the Oral Treatment of CNS Coccidioides Infections
    Edward P Garvey; Fiscal Year: 2013
    ..Coccidioidomycosis results from inhalation of fungal spores. Dissemination to the CNS results in coccidioidal meningitis (CM) and 100% mortality if untreated and 40% ..
  56. Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracis
    William W Barrow; Fiscal Year: 2013
    ..Inhalation anthrax is a life-threatening disease that would result from the release of Bacillus anthracis spores into the environment...
  57. Genetics Modifiers of Anthrax Lethal Toxin Induced Pathophysiology
    KENNETH ALAN BRADLEY; Fiscal Year: 2010
    ..and to reveal genetic factors that influence the presentation of LT induced disease well as resistance to spores. First, the qualitative trait loci (QTL) controlling early sensitivity will be mapped by complimentary approaches (..
  58. Phase I study of Clostridium novyi-NT spores in solid tumor cancer patients
    Luis A Diaz; Fiscal Year: 2010
    ..C. novyi-NT has undergone pre-clinical efficacy and toxicity evaluations in several animal models. C. novyi-NT spores delivered through a single intravenous dose to mice results in substantial tumor regressions in most animal models...
  59. Innate Immune Defense against Clostridium Difficile Infection
    Eric G Pamer; Fiscal Year: 2013
    ..Ingestion of infectious spores from contaminated environments represents the major route by which this infection is acquired...
  60. Small Molecule Blockers of B. anthracis Toxin
    Vladimir A Karginov; Fiscal Year: 2010
    ..tested in vivo and showed effective protection in rats challenged with lethal toxin and in mice infected with the spores of B. anthracis Sterne strain...
  61. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..identified a novel toxin called camelysin-like protein (CLP) which exerts immunogenic and is released from dormant spores during the early stage of the anthrax life cycle...
  62. CONTEMPORARY THERAPEUTICS FOR ANAPLASTIC GLIOMAS
    G Yancey Gillespie; Fiscal Year: 2013
    ..support this SPORE application We will continue our multiple, active collaborations with other Brain Tumor SPOREs and will foster new interactions with other non-brain organ site cancer SPORE programs locally and nationally...
  63. Combinatorial vaccines against anthrax and plague
    John Clements; Fiscal Year: 2006
    ..of individuals working in animal husbandry and military planners concerned about the potential use of anthrax spores as an agent of biological warfare...
  64. Development of Therapeutic Inhibitors to Anthrax Toxins
    JOHNNY PETERSON; Fiscal Year: 2006
    ..Anthrax is a highly infectious disease caused by Bacillus anthracis, and aerosolization of the dried bacterial spores is a major biological warfare and bioterrorism threat...
  65. Anaerobic Bacteria as Oncopathic Agents for Pancreatic Cancer
    Savio Woo; Fiscal Year: 2009
    ..We have also showed that the dormant spores of this deletion mutant, when administered intravenously in mice bearing an orthotopic model of pancreatic cancer, ..
  66. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    Germination occurs as an upstream event during the life cycle of Bacillus anthracis. Germinating spores may be considered the weakest link during its life cycle because stopping their function would prevent further development of the ..
  67. Immunoprotective monoclonals to B. anthracis spores
    ALISON O BRIEN; Fiscal Year: 2003
    Bacillus anthracis spores were recently used as agents of bioterrorism...
  68. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    ..Preliminary evidence indicates that the CREON2000 Photonic UV system disinfects the air it treats by killing mold spores and bacteria...
  69. STACHYBOTRYS INDUCED HEMORRHAGE IN THE DEVELOPING LUNG
    Dorr Dearborn; Fiscal Year: 2003
    ..The spores of this fungus do not germinate in the lung, but do not contain very potent mycotoxins which appear to be ..
  70. STERILIZING MEDICAL DEVICES WITH ATMOSPHERIC PLASMA
    Kimberly Kelly Wintenberg; Fiscal Year: 2001
    ..The OAUGDP has been shown to sterilize various surfaces against a number of microorganisms including viruses and spores. The use of atmospheric plasma to sterilize/decontaminate medical devices is, therefore, a new application of a ..
  71. Nisin as a decontaminant for B. anthracis spores on human skin
    Kenneth Alibek; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Project summary: An attack or terrorist event using spores of Bacillus anthracis continues to be an imminent threat...
  72. Detection of Category A Pathogens by Gold Nanoparticles
    Steven Wolinsky; Fiscal Year: 2007
    Recent deliberate exposure of civilian population of the United States populace to Bacillus anthracis spores uncovered an unmet need for tests to rapidly diagnose disease caused by this bacterium...
  73. STRATEGIES FOR INACTIVATING BACILLUS ANTHRACIS SPORES
    Arthur Aronson; Fiscal Year: 2003
    ..Its effectiveness as an agent is due to the ease of producing and spreading the spores. These spores are dormant and very resistant to a variety of stress conditions such as heat, ultraviolet radiation,..
  74. GENOME SEQUENCING OF ASPERGILLUS FUMIGATUS
    David Denning; Fiscal Year: 2001
    Aspergillus fumigatus is the most common cause of life-threatening mold infection (aspergillosis). Its spores are found in the air everywhere and are therefore unavoidable...
  75. Intervention against anthrax edema factor (EF)
    Wei Jen Tang; Fiscal Year: 2005
    The bioterrorism-related anthrax in 2001 has shown that anthrax spores can be an effective bioterrorism agent to cause massive disruption and causalities...
  76. Small Molecule Inhibitors of Anthrax Lethal Factor
    NORTON PEET; Fiscal Year: 2006
    Aerosolized spores of Bacillus anthracis represent one of the most serious bio-terrorist threats to the security of the United States...
  77. Escape of Bacillus anthracis from the phagsome
    Howard Goldfine; Fiscal Year: 2004
    In the pulmonary form of anthrax caused by the pathogen Bacillus anthracis (Ba), spores in the lung are ingested by macrophages. Once phagocytosed, the spores are transported to regional lymph nodes and germinate inside macrophages...