acinetobacter baumannii

Summary

Summary: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.

Top Publications

  1. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
  2. ncbi An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii
    Lenie Dijkshoorn
    Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Microbiol 5:939-51. 2007
  3. pmc Global challenge of multidrug-resistant Acinetobacter baumannii
    Federico Perez
    Division of Infectious Diseases and HIV Medicine, University Hospitals, Case Medical Centers, Cleveland, OH, USA
    Antimicrob Agents Chemother 51:3471-84. 2007
  4. pmc Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii
    Mark D Adams
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4955, USA
    J Bacteriol 190:8053-64. 2008
  5. pmc New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis
    Michael G Smith
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 21:601-14. 2007
  6. pmc Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, Ohio, USA
    Infect Immun 80:1015-24. 2012
  7. ncbi Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Ac
    Alexandr Nemec
    Laboratory of Bacterial Genetics, National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic
    Res Microbiol 162:393-404. 2011
  8. pmc The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, Department of Medicine, Division of Infectious Diseases, University at Buffalo, 3435 Main St, Biomedical Research Building Room 141, Buffalo, NY 14214, USA
    Infect Immun 78:3993-4000. 2010
  9. pmc Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii
    Sergio G Bartual
    Division de Microbiologia and Evolutionary Genomics Group, Campus de San Juan, Universidad Miguel Hernandez, San Juan de Alicante, Spain
    J Clin Microbiol 43:4382-90. 2005
  10. pmc Genome organization of epidemic Acinetobacter baumannii strains
    Pier Paolo Di Nocera
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S, Pansini 5, 80131 Napoli, Italy
    BMC Microbiol 11:224. 2011

Detail Information

Publications342 found, 100 shown here

  1. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
    b>Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally...
  2. ncbi An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii
    Lenie Dijkshoorn
    Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Microbiol 5:939-51. 2007
    ..Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii.
  3. pmc Global challenge of multidrug-resistant Acinetobacter baumannii
    Federico Perez
    Division of Infectious Diseases and HIV Medicine, University Hospitals, Case Medical Centers, Cleveland, OH, USA
    Antimicrob Agents Chemother 51:3471-84. 2007
  4. pmc Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii
    Mark D Adams
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4955, USA
    J Bacteriol 190:8053-64. 2008
    The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii has raised concern in health care settings worldwide...
  5. pmc New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis
    Michael G Smith
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 21:601-14. 2007
    b>Acinetobacter baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections including pneumonia, meningitis, septicemia, and urinary tract infections...
  6. pmc Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, Ohio, USA
    Infect Immun 80:1015-24. 2012
    b>Acinetobacter baumannii, which causes serious infections in immunocompromised patients, expresses high-affinity iron acquisition functions needed for growth under iron-limiting laboratory conditions...
  7. ncbi Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Ac
    Alexandr Nemec
    Laboratory of Bacterial Genetics, National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic
    Res Microbiol 162:393-404. 2011
    ..sp. 13TU are increasingly recognized as clinically important taxa within the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex...
  8. pmc The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, Department of Medicine, Division of Infectious Diseases, University at Buffalo, 3435 Main St, Biomedical Research Building Room 141, Buffalo, NY 14214, USA
    Infect Immun 78:3993-4000. 2010
    b>Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii...
  9. pmc Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii
    Sergio G Bartual
    Division de Microbiologia and Evolutionary Genomics Group, Campus de San Juan, Universidad Miguel Hernandez, San Juan de Alicante, Spain
    J Clin Microbiol 43:4382-90. 2005
    In this study a multilocus sequence typing (MLST) scheme for Acinetobacter baumannii was developed and evaluated by using 40 clinical A...
  10. pmc Genome organization of epidemic Acinetobacter baumannii strains
    Pier Paolo Di Nocera
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S, Pansini 5, 80131 Napoli, Italy
    BMC Microbiol 11:224. 2011
    b>Acinetobacter baumannii is an opportunistic pathogen responsible for hospital-acquired infections. A. baumannii epidemics described world-wide were caused by few genotypic clusters of strains...
  11. pmc Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China
    Hua Zhou
    Department of Respiratory Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Antimicrob Agents Chemother 55:4506-12. 2011
    We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China...
  12. pmc Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group
    Michele Iacono
    National Research Council, Segrate, Milan 20090, Italy
    Antimicrob Agents Chemother 52:2616-25. 2008
    The whole-genome sequence of an epidemic, multidrug-resistant Acinetobacter baumannii strain (strain ACICU) belonging to the European clone II group and carrying the plasmid-mediated bla(OXA)(-)(58) carbapenem resistance gene was ..
  13. pmc Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis
    Anna C Jacobs
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5900, USA
    Infect Immun 78:1952-62. 2010
    b>Acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. Nonetheless, relatively little is known about the organism's virulence factors or their regulatory networks...
  14. pmc Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    BMC Microbiol 8:216. 2008
    b>Acinetobacter baumannii is a nosocomial pathogen of increasing importance, but the pathogenic mechanism of this microorganism has not been fully explored. This study investigated the potential of A...
  15. pmc Comparative genomics of multidrug resistance in Acinetobacter baumannii
    Pierre Edouard Fournier
    Information Genomique et Structurale, Institute for Structural Biology and Microbiology, IBSM, Marseille, France
    PLoS Genet 2:e7. 2006
    b>Acinetobacter baumannii is a species of nonfermentative gram-negative bacteria commonly found in water and soil. This organism was susceptible to most antibiotics in the 1970s...
  16. ncbi Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    Cell Microbiol 7:1127-38. 2005
    b>Acinetobacter baumannii is an important opportunistic pathogen responsible for nosocomial infection. Despite considerable clinical and epidemiological data regarding the role of A...
  17. pmc Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii
    Evan S Snitkin
    Epithelial Biology Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:13758-63. 2011
    b>Acinetobacter baumannii is an emerging human pathogen and a significant cause of nosocomial infections among hospital patients worldwide...
  18. pmc Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Rome, Italy
    PLoS ONE 6:e22674. 2011
    b>Acinetobacter baumannii is an emerging bacterial pathogen that causes a broad array of infections, particularly in hospitalized patients. Many studies have focused on the epidemiology and antibiotic resistance of A...
  19. ncbi Proteomic analysis of Acinetobacter baumannii in biofilm and planktonic growth mode
    Ji Hyun Shin
    Department of Microbiology, Kyungpook National University, School of Medicine, Daegu 700 422, Republic of Korea
    J Microbiol 47:728-35. 2009
    Recently, multidrug-resistant clinical isolates of Acinetobacter baumannii have been found to have a high capacity to form biofilm...
  20. ncbi Insights into Acinetobacter baumannii pathogenicity
    Gustavo M Cerqueira
    Faculty of Medicine, Nursing and Health Sciences, Department of Microbiology, Monash University, Melbourne, Australia
    IUBMB Life 63:1055-60. 2011
    ..Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a "red-alert" human pathogen, primarily because of its exceptional ability to develop ..
  21. pmc AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii
    Laurence Damier-Piolle
    Unite des Agents Antibacteriens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 52:557-62. 2008
    ..a second resistance-nodulation-cell division (RND)-type efflux pump, AdeIJK, in clinical isolate Acinetobacter baumannii BM4454...
  22. ncbi Influence of genospecies of Acinetobacter baumannii complex on clinical outcomes of patients with acinetobacter bacteremia
    Yu Chung Chuang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 52:352-60. 2011
    b>acinetobacter baumannii complex infections are increasing in prevalence and are associated with a high mortality. Biochemical classification tests cannot differentiate A. baumannii (genospecies 2) from other genospecies...
  23. ncbi Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology
    Andrew P Tomaras
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Microbiology 154:3398-409. 2008
    b>Acinetobacter baumannii forms biofilms on abiotic surfaces, a phenotype that may explain its ability to survive in nosocomial environments and to cause device-related infections in compromised patients...
  24. pmc Regulation of Acinetobacter baumannii biofilm formation
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Future Microbiol 4:273-8. 2009
    b>Acinetobacter baumannii is a Gram-negative opportunistic nosocomial pathogen. This microorganism survives in hospital environments despite unfavorable conditions such as desiccation, nutrient starvation and antimicrobial treatments...
  25. pmc Do biofilm formation and interactions with human cells explain the clinical success of Acinetobacter baumannii?
    Anna de Breij
    Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS ONE 5:e10732. 2010
    ..in antibiotic resistance and the recent manifestation in war trauma patients underscore the threat of Acinetobacter baumannii as a nosocomial pathogen...
  26. pmc The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Infect Immun 77:3150-60. 2009
    The ability of Acinetobacter baumannii to adhere to and persist on surfaces as biofilms could be central to its pathogenicity...
  27. pmc Complete genome sequence of multidrug-resistant Acinetobacter baumannii strain 1656-2, which forms sturdy biofilm
    Jin Yeol Park
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700 422, Republic of Korea
    J Bacteriol 193:6393-4. 2011
    b>Acinetobacter baumannii is a Gram-negative bacterium causing nosocomial infections worldwide. To gain quick insight into the molecular basis of biofilm formation in A. baumannii, we determined the complete genome sequence of A...
  28. pmc The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool
    Laure Diancourt
    Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
    PLoS ONE 5:e10034. 2010
    Outbreaks of hospital infections caused by multidrug resistant Acinetobacter baumannii strains are of increasing concern worldwide...
  29. pmc Identification of a general O-linked protein glycosylation system in Acinetobacter baumannii and its role in virulence and biofilm formation
    Jeremy A Iwashkiw
    Alberta Glycomics Centre, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS Pathog 8:e1002758. 2012
    b>Acinetobacter baumannii is an emerging cause of nosocomial infections. The isolation of strains resistant to multiple antibiotics is increasing at alarming rates. Although A...
  30. pmc Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii
    Michael J McConnell
    Unit of Infectious Disease, Microbiology, and Preventive Medicine, Hospitales Universitarios Virgen del Rocio, Edificio Laboratorio Anexo Caracola, Avenida Manuel Siurot s n, 41013 Seville, Spain
    Infect Immun 79:518-26. 2011
    b>Acinetobacter baumannii causes pneumonias, bacteremias, and skin and soft tissue infections, primarily in the hospitalized setting. The incidence of infections caused by A...
  31. ncbi Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the United States
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr 19 21, 50935 Cologne, Germany
    J Infect 64:282-90. 2012
    ..features and antimicrobial susceptibilities of the clinically most important Acinetobacter species Acinetobacter baumannii, Acinetobacter pittii (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis (formerly ..
  32. pmc The Acinetobacter baumannii biofilm-associated protein plays a role in adherence to human epithelial cells
    Kari A Brossard
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, The State Univesity of New York, Buffalo, NY, USA
    Infect Immun 80:228-33. 2012
    b>Acinetobacter baumannii is a significant source of nosocomial infections worldwide...
  33. pmc Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosamine
    Rebekah Henry
    Department of Microbiology, Monash University, Clayton, Australia
    Antimicrob Agents Chemother 56:59-69. 2012
    We recently demonstrated that colistin resistance in Acinetobacter baumannii can result from mutational inactivation of genes essential for lipid A biosynthesis (Moffatt JH, et al., Antimicrob. Agents Chemother. 54:4971-4977)...
  34. pmc Genomic comparison of multi-drug resistant invasive and colonizing Acinetobacter baumannii isolated from diverse human body sites reveals genomic plasticity
    Jason W Sahl
    Department of Microbiology, Institute for Genome Sciences, Baltimore, MD 21201, USA
    BMC Genomics 12:291. 2011
    b>Acinetobacter baumannii has recently emerged as a significant global pathogen, with a surprisingly rapid acquisition of antibiotic resistance and spread within hospitals and health care institutions...
  35. ncbi A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids
    R B Patwardhan
    Department of Microbiology, University of Pune, Pune, India
    Indian J Med Res 128:178-87. 2008
    ..Present investigation was undertaken to know antibiotic resistance in Acinetobacter baumannii and some other pathogens obtained from clinical samples from ICU causing nosocomial infections...
  36. pmc Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii
    Chen Niu
    Department of Microbiology and Immunology, Emory University School of Medicine, 3001 Rollins Research Center, Atlanta, GA, USA
    J Bacteriol 190:3386-92. 2008
    The opportunistic human pathogen Acinetobacter baumannii strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an Agrobacterium tumefaciens traG-lacZ biosensor. An A...
  37. ncbi Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options
    Lisa L Maragakis
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 46:1254-63. 2008
    Multidrug-resistant Acinetobacter baumannii is recognized to be among the most difficult antimicrobial-resistant gram-negative bacilli to control and treat...
  38. ncbi Capacity of multidrug-resistant clinical isolates of Acinetobacter baumannii to form biofilm and adhere to epithelial cell surfaces
    H W Lee
    Department of Microbiology, Kyungpook National University, School of Medicine, Daegu, Korea
    Clin Microbiol Infect 14:49-54. 2008
    This study evaluated the capacity of 23 multidrug-resistant (MDR) clinical isolates of Acinetobacter baumannii to adhere to respiratory epithelial cell surfaces and to form biofilm on a polystyrene surface. All 23 A...
  39. pmc Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles
    Jong Sook Jin
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    PLoS ONE 6:e17027. 2011
    b>Acinetobacter baumannii is an important nosocomial pathogen that causes a high morbidity and mortality rate in infected patients, but pathogenic mechanisms of this microorganism regarding the secretion and delivery of virulence factors ..
  40. pmc Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii
    Mark D Adams
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 54:3569-77. 2010
    Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the ..
  41. ncbi Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    Cell Microbiol 10:309-19. 2008
    b>Acinetobacter baumannii is an emerging opportunistic pathogen responsible for healthcare-associated infections. The outer membrane protein A of A...
  42. ncbi Adherence of Acinetobacter baumannii strains to human bronchial epithelial cells
    Je Chul Lee
    Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 101, Dongin 2 ga, Jung Gu, Daegu 700 422, South Korea
    Res Microbiol 157:360-6. 2006
    b>Acinetobacter baumannii is an important nosocomial pathogen, but the mechanisms contributing to its epidemicity and virulence are largely unknown. The organism is able to colonize skin and mucosal surfaces of the human host...
  43. ncbi Multiresistant Acinetobacter baumannii infections: epidemiology and management
    Jose Garnacho-Montero
    Critical Care and Emergency Department, Intensive Care Unit, Virgen del Rocio University Hospital, Seville, Spain
    Curr Opin Infect Dis 23:332-9. 2010
    We present recent data about epidemiology of Acinetobacter baumannii in the hospital setting, major resistance mechanisms, and therapeutic options for infections caused by multidrug-resistant strains.
  44. ncbi Serum resistance of Acinetobacter baumannii through the binding of factor H to outer membrane proteins
    Sang Woo Kim
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    FEMS Microbiol Lett 301:224-31. 2009
    Bacteremia is a common systemic disease caused by Acinetobacter baumannii, an important hospital-acquired pathogen among critically ill patients...
  45. ncbi Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii
    Daniel L Zimbler
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Biometals 22:23-32. 2009
    b>Acinetobacter baumannii is a gram-negative bacterium that causes serious infections in compromised patients. More recently, it has emerged as the causative agent of severe infections in military personnel wounded in Iraq and Afghanistan...
  46. pmc Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice
    Henk van Faassen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Infect Immun 75:5597-608. 2007
    b>Acinetobacter baumannii has emerged as a major cause of both community-associated and nosocomial pneumonia, but little is known about the cellular and molecular mechanisms of host defense against respiratory infection with this bacterial ..
  47. ncbi Global spread of carbapenem-resistant Acinetobacter baumannii
    Paul G Higgins
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
    J Antimicrob Chemother 65:233-8. 2010
    We have investigated the molecular epidemiology and distribution of carbapenemase genes in 492 imipenem-non-susceptible Acinetobacter baumannii worldwide isolates (North and Latin America, Europe, Asia, South Africa and Australia).
  48. ncbi The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, London, UK
    FEMS Microbiol Lett 258:72-7. 2006
    ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/or blaOXA-58-like...
  49. ncbi Current control and treatment of multidrug-resistant Acinetobacter baumannii infections
    Drosos E Karageorgopoulos
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Lancet Infect Dis 8:751-62. 2008
    Institutional outbreaks caused by Acinetobacter baumannii strains that have acquired multiple mechanisms of antimicrobial drug resistance constitute a growing public-health problem...
  50. ncbi Biofilm formation by Acinetobacter baumannii strains isolated from urinary tract infection and urinary catheters
    Nadia Kazemi Pour
    Department of Microbiology, University of Pune, Pune, India
    FEMS Immunol Med Microbiol 62:328-38. 2011
    ..Analytical profile index assays identified 47 isolates as Acinetobacter baumannii and three as Acinetobacter lwoffii. Six A...
  51. pmc Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance
    Jessica M Breslow
    Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Infect Immun 79:3317-27. 2011
    b>Acinetobacter baumannii is a nosocomial pathogen with a high prevalence of multiple-drug-resistant strains, causing pneumonia and sepsis...
  52. pmc Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system
    Alejandro Beceiro
    Health Protection Agency, Microbiology Services Colindale, London, United Kingdom
    Antimicrob Agents Chemother 55:3370-9. 2011
    Colistin resistance is rare in Acinetobacter baumannii, and little is known about its mechanism...
  53. pmc Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions
    Bart A Eijkelkamp
    School of Biological Sciences, Flinders University, Adelaide, SA 5001, Australia
    BMC Genomics 12:126. 2011
    ..To identify these systems in Acinetobacter baumannii, the transcriptomic response of the completely sequenced strain ATCC 17978 under iron limiting conditions ..
  54. pmc Genome sequence of Acinetobacter baumannii MDR-TJ
    Feng Gao
    Department of Physics, Tianjin University, Tianjin 300072, China
    J Bacteriol 193:2365-6. 2011
    b>Acinetobacter baumannii is a pathogenic species of bacteria, identified as an aerobic gram-negative bacterium, that is resistant to most antibiotics...
  55. ncbi Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system
    Andrew P Tomaras
    Department of Microbiology, Miami University, 40 Pearson Hall, Oxford, OH 45056, USA
    Microbiology 149:3473-84. 2003
    b>Acinetobacter baumannii causes severe infections in compromised patients, survives on abiotic surfaces in hospital environments and colonizes different medical devices...
  56. ncbi Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii
    Michael J McConnell
    Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla IBIS, University Hospital Virgen del Rocío CSIC University of Sevilla, 41013 Sevilla, Spain
    Vaccine 29:5705-10. 2011
    b>Acinetobacter baumannii produces different types of infections including pneumonia, meningitis, and bloodstream infections...
  57. pmc Prevalence and characterization of class I integrons among Pseudomonas aeruginosa and Acinetobacter baumannii isolates from patients in Nanjing, China
    Bing Gu
    Department of Clinical Laboratories, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    J Clin Microbiol 45:241-3. 2007
    Class I integrons were detected in 40.8% (40/98) of Pseudomonas aeruginosa strains and 52.8% (56/106) of Acinetobacter baumannii strains in the Nanjing area of China, including several cassette arrays not previously reported.
  58. ncbi Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007
    Yvonne Pfeifer
    Nosocomial Infections, Robert Koch Institute, Burgstraße 37, 38855 Wernigerode, Germany
    J Antimicrob Chemother 66:1998-2001. 2011
    To investigate the genetic environment of the metallo-β-lactamase gene bla(NDM-1) in an Acinetobacter baumannii isolated in 2007 in a German hospital.
  59. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
    ..Since Acinetobacter baumannii infection can modulate lung cellular and cytokine responses, we studied the effect of A...
  60. ncbi Confronting multidrug-resistant Acinetobacter baumannii: a review
    Ioannis K Neonakis
    Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece
    Int J Antimicrob Agents 37:102-9. 2011
    Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are difficult to treat owing to the extremely limited armamentarium...
  61. pmc AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters
    Xian Zhong Su
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Antimicrob Agents Chemother 49:4362-4. 2005
    We cloned a gene, abeM, for a multidrug efflux pump from Acinetobacter baumannii using Escherichia coli as the host. Sequence analysis revealed that AbeM is a member of the MATE family of pumps...
  62. ncbi Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia
    Ia Kusradze
    G Eliava Institute of Bacteriophages, Microbiology and Virology Gotua str 3, 0160 Tbilisi, Georgia
    Int J Antimicrob Agents 38:164-8. 2011
    The aim of this study was to determine the susceptibility to imipenem (IPM) of Acinetobacter baumannii isolates from different countries and to characterise the carbapenemase-encoding genes in IPM-resistant isolates. A total of 12 A...
  63. pmc Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii
    Sébastien Coyne
    Institut Pasteur, Unite des Agents Antibacteriens, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 54:4389-93. 2010
    b>Acinetobacter baumannii is a major nosocomial pathogen which frequently develops multidrug resistance by acquisition of antibiotic resistance genes and overexpression of intrinsic efflux systems, such as the RND efflux pumps AdeABC and ..
  64. pmc Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections
    John S Esterly
    Department of Pharmacy Practice, Chicago State University College of Pharmacy, Chicago, Illinois, USA
    Antimicrob Agents Chemother 55:4844-9. 2011
    Nosocomial Acinetobacter baumannii bloodstream infections occur with significant prevalence and mortality. The relationship between carbapenem resistance in A. baumannii and patient outcomes remains unclear...
  65. pmc blaNDM-1 is a chimera likely constructed in Acinetobacter baumannii
    M A Toleman
    Department of Medical Microbiology and Infection, the Heath Hospital, Cardiff University, Cardiff, United Kingdom
    Antimicrob Agents Chemother 56:2773-6. 2012
    ..This is unequivocal evidence that bla(NDM-1) is a chimera...
  66. pmc Multidrug-resistant Acinetobacter baumannii Harboring OXA-24 carbapenemase, Spain
    Joshi Acosta
    Hospital Universitario 12 de Octubre, Madrid, Spain
    Emerg Infect Dis 17:1064-7. 2011
    In February 2006, a patient colonized with a multidrug-resistant sequence type 56 Acinetobacter baumannii strain was admitted to a hospital in Madrid, Spain. This strain spread rapidly and caused a large outbreak in the hospital...
  67. pmc The opportunistic human pathogen Acinetobacter baumannii senses and responds to light
    María A Mussi
    Department of Microbiology, Miami University, Oxford, Ohio 45056, USA
    J Bacteriol 192:6336-45. 2010
    ..In this work, we show that the opportunistic pathogen Acinetobacter baumannii senses and responds to blue light...
  68. pmc Genome sequence of a dominant, multidrug-resistant Acinetobacter baumannii strain, TCDC-AB0715
    Chun Chen Chen
    Research and Diagnostic Center, Centers for Disease Control, No 161, Kun Yang Street, Taipei 115, Taiwan
    J Bacteriol 193:2361-2. 2011
    b>Acinetobacter baumannii has emerged as a significant nosocomial pathogen worldwide. The increasing trend of carbapenem and fluoroquinolone resistance in A. baumannii severely limits the usage of therapeutic antimicrobial agents...
  69. pmc Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I
    Lenka Krizova
    Laboratory of Bacterial Genetics, National Institute of Public Health, Srobarova 48, 100 42 Prague, Czech Republic
    Antimicrob Agents Chemother 55:3201-6. 2011
    To assess the diversity of AbaR genomic resistance islands in Acinetobacter baumannii European clone I (MLST clonal complex 1), we investigated 26 multidrug-resistant strains of this major clone isolated from hospitals in 21 cities of 10 ..
  70. ncbi Multidrug-resistant Acinetobacter baumannii: an emerging pathogen among older adults in community hospitals and nursing homes
    D M Sengstock
    Internal Medicine Geriatrics, Oakwood Hospital, Dearborn, Michigan, USA
    Clin Infect Dis 50:1611-6. 2010
    ..Drug-resistant Acinetobacter species are problematic in tertiary-care hospitals. We describe the epidemiology, resistance patterns, and outcomes of older adults with Acinetobacter infection in community hospitals...
  71. pmc Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3849-54. 2011
    b>Acinetobacter baumannii is emerging as an important nosocomial pathogen worldwide. We report molecular epidemiology of 65 carbapenem-nonsusceptible A...
  72. pmc Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics
    Anton Y Peleg
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antimicrob Agents Chemother 53:2605-9. 2009
    ..mellonella caterpillars to study host-pathogen interactions with the gram-negative organism Acinetobacter baumannii and determine the utility of this infection model to study antibacterial efficacy. After infecting G...
  73. ncbi Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
    Alexandre P Zavascki
    Infectious Diseases Unit, Hospital de Clinicas de Porto Alegre, 2350 Ramiro Barcelos Street, 90035 903, Porto Alegre, Brazil
    Expert Rev Anti Infect Ther 8:71-93. 2010
    Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to virtually any antimicrobial agent...
  74. ncbi Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport
    Caleb W Dorsey
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Microbiology 149:1227-38. 2003
    The Acinetobacter baumannii 8399 clinical isolate secretes dihydroxybenzoic acid (DHBA) and a high-affinity catechol siderophore, which is different from other bacterial iron chelators already characterized...
  75. ncbi Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, The Witebsky Center for Microbial Pathogenesis, Department of Medicine, State University of New York Buffalo, Buffalo, New York 14214, USA
    J Infect Dis 199:513-21. 2009
    b>Acinetobacter baumannii is a bacterial pathogen of increasing medical importance. Little is known about genes important for its survival in vivo.
  76. ncbi Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance
    Nicola C Gordon
    Division of Infection, Barts and The London NHS Trust, London, UK
    Int J Antimicrob Agents 35:219-26. 2010
    Infection due to Acinetobacter baumannii has become a significant challenge to modern healthcare systems. The organism shows a formidable capacity to develop antimicrobial resistance, yet the clinical impact of A...
  77. pmc Characterization and PCR-based replicon typing of resistance plasmids in Acinetobacter baumannii
    Alessia Bertini
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Antimicrob Agents Chemother 54:4168-77. 2010
    b>Acinetobacter baumannii is an opportunistic pathogen, especially in intensive care units, and multidrug-resistant isolates have increasingly been reported during the last decade...
  78. pmc Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea
    Kyungwon Lee
    Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchondong, Seodaemunku, Seoul 120 752, Korea
    Antimicrob Agents Chemother 49:4485-91. 2005
    ..Of these, 204 (96%) had either the bla(IMP-1) or bla(VIM-2) allele. In addition, seven Acinetobacter baumannii isolates were found to have a novel MBL gene, which was designated bla(SIM-1)...
  79. ncbi Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment
    J M Cisneros
    Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocio, Spain
    Clin Microbiol Infect 8:687-93. 2002
    b>Acinetobacter baumannii is an important cause of nosocomial infections in many hospitals...
  80. pmc The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation
    Alexis H K Choi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 191:5953-63. 2009
    We found that Acinetobacter baumannii contains a pgaABCD locus that encodes proteins that synthesize cell-associated poly-beta-(1-6)-N-acetylglucosamine (PNAG)...
  81. ncbi Genetic basis of multidrug-resistant Acinetobacter baumannii clinical isolates from three university hospitals in Chungcheong Province, Korea
    Sun Hoe Koo
    Department of Laboratory Medicine, College of Medicine, Chungnam National University, Daejeon, Korea
    Korean J Lab Med 30:498-506. 2010
    The emergence of multidrug-resistant (MDR) Acinetobacter baumannii as an important opportunistic pathogen has given rise to significant therapeutic challenges in the treatment of nosocomial infections...
  82. pmc Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system
    Mark D Adams
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Antimicrob Agents Chemother 53:3628-34. 2009
    The mechanism of colistin resistance (Col(r)) in Acinetobacter baumannii was studied by selecting in vitro Col(r) derivatives of the multidrug-resistant A...
  83. ncbi Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides
    Y Zhou
    Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M Wulumuqi Road, 200040, Shanghai, China
    Eur J Clin Microbiol Infect Dis 29:1349-53. 2010
    ..55 strains). Genes for armA or rmtB were detected in 94.7% (89/94) of Acinetobacter baumannii and Pseudomonas aeruginosa strains, and armA was predominant (84 vs. 5 strains with rmtB)...
  84. ncbi Global comparison of the membrane subproteomes between a multidrug-resistant Acinetobacter baumannii strain and a reference strain
    Axel Siroy
    IBBR Group, Laboratory Polymères, Biopolymères, Membranes, UMR 6522 CNRS, University of Rouen, France
    J Proteome Res 5:3385-98. 2006
    b>Acinetobacter baumannii causes severe infections in compromised patients...
  85. ncbi Evolution of AbaR-type genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii
    Virginia Post
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia
    J Antimicrob Chemother 65:1162-70. 2010
    To determine if members of the European clonal lineages are present amongst multiply antibiotic-resistant Acinetobacter baumannii isolates from Australia...
  86. ncbi Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii
    Jordi Vila
    Servei de Microbiologia, Centre de Diagnostic Biomedic, Hospital Clinic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Antimicrob Chemother 59:1210-5. 2007
    b>Acinetobacter baumannii is an opportunistic pathogen, causing infections mainly in patients in intensive care units where the extensive use of antimicrobial agents can select for the emergence of multiresistant strains...
  87. ncbi Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates
    Luísa C S Antunes
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Roma, Italy
    Res Microbiol 162:279-84. 2011
    New putative iron-uptake genes were identified in published genomes of the opportunistic human pathogen Acinetobacter baumannii, and their occurrence was determined in a genotypically distinct collection of 50 clinical isolates by PCR ..
  88. ncbi Acinetobacter baumannii 2002-2008: increase of carbapenem-associated multiclass resistance in the United States
    Robertino M Mera
    Department of Research Statistics, GlaxoSmithKline, Durham, North Carolina 27709, USA
    Microb Drug Resist 16:209-15. 2010
    The study consisted of data for 55,330 U.S. Acinetobacter baumannii isolates from The Surveillance Network(®) database for the period 2002-2008. Risk factors were time, age, sex, census region, location (Ward or ICU), and isolate source...
  89. pmc OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak
    Maria Merino
    Laboratorio de Microbiologia, Complejo Hospitalario Universitario A Coruña, Xubias s n, 3 Planta Ed Sur, 15006 La Coruna, Spain
    Antimicrob Agents Chemother 54:2724-7. 2010
    ..a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A...
  90. pmc Deciphering the iron response in Acinetobacter baumannii: A proteomics approach
    Chika C Nwugo
    Department of Microbiology, Miami University, Oxford, Ohio, USA
    J Proteomics 74:44-58. 2011
    ..The iron-induced production of OmpA suggests this protein plays a role in iron metabolism as shown by the diminished ability of an isogenic OmpA deficient derivative to grow under iron-chelated conditions...
  91. ncbi Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting
    Jun Sik Lee
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 700 422, Republic of Korea
    J Microbiol 48:387-92. 2010
    b>Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined...
  92. ncbi Characterization of Acinetobacter baumannii carrying bla(OXA-23), bla(PER-1) and armA in a Korean hospital
    J W Kim
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    Clin Microbiol Infect 14:716-8. 2008
    Forty-two multidrug-resistant (MDR) Acinetobacter baumannii isolates were obtained during outbreaks in a Korean hospital...
  93. ncbi Acinetobacter: an old friend, but a new enemy
    K J Towner
    Department of Clinical Microbiology, Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Hosp Infect 73:355-63. 2009
    ..Most clinically significant isolates belong to the species Acinetobacter baumannii or its close relatives, with many infections concentrated in intensive care, burns or high dependency ..
  94. pmc Detection and analysis of iron uptake components expressed by Acinetobacter baumannii clinical isolates
    Caleb W Dorsey
    Department of Microbiology, Miami University, Oxford, Ohio 45056, USA
    J Clin Microbiol 41:4188-93. 2003
    The Acinetobacter baumannii 19606 prototype strain produces a 78-kDa iron-regulated outer membrane protein immunologically related to FatA, which is required for iron acquisition by the fish pathogen Vibrio anguillarum via the ..
  95. ncbi The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:187-95. 2006
    b>Acinetobacter baumannii is an emerging pathogen in nosocomial pneumonia. Trauma and postsurgical patients display a profound acute-phase protein response and are susceptible to pneumonia.
  96. pmc Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
    María A Mussi
    Instituto de Biologia Molecular y Celular de Rosario IBR, CONICET and Departamento de Microbiología, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    Antimicrob Agents Chemother 49:1432-40. 2005
    ..for the influx of carbapenem beta-lactam antibiotics in the nonfermentative gram-negative pathogen Acinetobacter baumannii are still poorly characterized...
  97. ncbi High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea
    Kwan Soo Ko
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea
    J Antimicrob Chemother 60:1163-7. 2007
    ..To investigate antimicrobial resistance in clinical isolates of Acinetobacter spp. from two Korean hospitals...
  98. ncbi Genome-scale metabolic network analysis and drug targeting of multi-drug resistant pathogen Acinetobacter baumannii AYE
    Hyun Uk Kim
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Republic of Korea
    Mol Biosyst 6:339-48. 2010
    b>Acinetobacter baumannii has emerged as a new clinical threat to human health, particularly to ill patients in the hospital environment...
  99. ncbi Global spread of drug-resistant Acinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance
    Emanuele Durante-Mangoni
    Chair of Internal Medicine and Unit of Transplant Medicine, Second University of Naples, Monaldi Hospital, Naples, Italy
    Future Microbiol 6:407-22. 2011
    b>Acinetobacter baumannii is an opportunistic Gram-negative pathogen with increasing relevance in a variety of hospital-acquired infections especially among intensive care unit patients...
  100. pmc Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, Department of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, NY 14214, USA
    Infect Immun 76:3577-86. 2008
    b>Acinetobacter baumannii is a bacterial pathogen of increasing medical importance. Little is known about its mechanisms of pathogenesis, and safe reliable agents with predictable activity against A. baumannii are presently nonexistent...
  101. ncbi AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains
    Stéphane Corvec
    Laboratoire de Bacteriologie virologie, Hygiene Hospitaliere, CHU, Nantes, France
    J Antimicrob Chemother 52:629-35. 2003
    To compare the genetic environments of ampC genes in different Acinetobacter baumannii isolates showing different levels of beta-lactam resistance.

Research Grants48

  1. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..have experienced outbreaks of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Enterobacter species, Enterococcus faecium and Staphyloccocus aureus...
  2. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..Gram-negative bacilli that are of major concern in human health, in particular the species Acinetobacter baumannii. They are responsible for clinically important infections that cause a wide variety of maladies including ..
  3. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..be growth inhibition of both ATCC and clinical strains of multiple drug resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae...
  4. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2013
    ..b>Acinetobacter baumannii, and Pseudomonas aeruginosa...
  5. Novel gene-silencing therapeutics for multidrug-resistant gram-negative pathogens
    DAVID ELIHU GREENBERG; Fiscal Year: 2013
    ..This group includes the Gram-negative pathogens Acinetobacter baumannii and Escherichia coli...
  6. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acinetobacter baumannii is one of the most frequently isolated bacteria from patients with ventilator-associated pneumonia and causes a diverse number of infections, particularly in highly ..
  7. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..actions in Iraq and Afghanistan confirmed the emergence of multi-drug resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas ..
  8. Development of an antimicrobial peptide therapeutic for Pseudomonas infections
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..have potent antimicrobial activity for Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii. Of additional importance to the antibiotic activity of CAP37 peptides, is their ability to bind and ..
  9. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..focus of this application will be on the organism Mycobacterium tuberculosis;however, the Gram-negative Acinetobacter baumannii and Klebsiella pneumoniae will also be pursued...
  10. Mechanisms of Action of UmuD in Regulating DNA Damage-Induced Genes in a umuC Def
    Janelle M Hare; Fiscal Year: 2013
    ..baylyi as well as in the opportunistic pathogen Acinetobacter baumannii, which conducts UV-induced mutagenesis and has both the ddrR-umuDAb locus and an E...
  11. Host-mediated zinc sequestration during Acinetobacter baumannii infection
    Eric P Skaar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acinetobacter baumannii is an important nosocomial pathogen that causes a range of diseases, including respiratory and urinary tract infections, meningitis, endocarditis, wound infections, and ..
  12. Mass Spectrometric Characterization of Lipopolysaccharides
    Jennifer S Brodbelt; Fiscal Year: 2013
    ..Camphorbacter jejuni and Vibrio cholera remain among the most common causes of diarrheal illness, and Acinetobacter baumannii is responsible for a growing number of the antibiotic-resistant infections in hospitals...
  13. Discovery of Polymyxin-based Antibacterial Agents Active Against Multi-Drug Resis
    Lawrence H Lash; Fiscal Year: 2013
    ..In particular, the expansion of Gram-negative strains such as Klebsiella pneumonia, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa and the rapidly spreading NDM-1 phenotypes are of grave concern...
  14. The Use of Polyamines in Treatment of Multidrug-Resistant Gram-Negative Pathogens
    Dong Hyeon Kwon; Fiscal Year: 2013
    ..healthcare-infections and nosocomial outbreaks are Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. PI discovered that exogenous polyamines (spermine, spermidine, and putrescine) in combination with 2-..
  15. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2013
    ..in clinical isolates of vancomycin-resistant enterococci (VRE) and to tigecycline resistance in Acinetobacter baumannii. QED can be applied across many organisms and antibiotics to provide: 1) conceptual and mechanistic ..
  16. Synthetic lethality of bicyclomycin
    KARL A DRLICA; Fiscal Year: 2013
    ..However, co-treatment of E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii with bicyclomycin plus a second inhibitor of gene expression (e.g...
  17. Multidrug-Resistant Acinetobacter baumannii
    Yohei Doi; Fiscal Year: 2010
    b>Acinetobacter baumannii is a Gram-negative, non-lactose-fermenting organism that causes serious nosocomial infections such as ventilator-associated pneumonia and bacteremia. A...
  18. IMPDH-targeted antibiotics for select agents
    LIZBETH K HEDSTROM; Fiscal Year: 2013
    ..mallei/pseudomallei (Gram-negative facultative intracellular), Staphylococcus aureus (Gram-positive) and Acinetobacter baumannii (Gram-negative). These pathogens pose some of the most serious threats to human health;B. anthracis, Bu...
  19. Molecular Antibiotic Resistance Arrays for clinical microbiology laboratories
    PAUL STEPHEN KEIM; Fiscal Year: 2013
    ..characterize antibiotic resistance in important pathogens (Pseudomonas aeruginosa, Klebsiella pneumonia, Acinetobacter baumannii, Staphylococcus aureus, and Streptococcus pneumoniae) in clinical samples...
  20. Humanized Monoclonal Antibodies to Treat Acinetobacter Infections
    Brad J Spellberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the last decade, Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant pathogens in the United States (US) and throughout the world...
  21. Acinetobacter virulence and host immunopathogenesis
    Brad J Spellberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acinetobacter baumannii is one of the most highly antibiotic-resistant organisms in the United States (US) and throughout the world. Up to 70% of A...
  22. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..as well as carbapenem-resistant strains, including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii isolates...
  23. ArmR: a novel drug target and mediator of antibiotic resistance
    David S Weiss; Fiscal Year: 2013
    ..b>Acinetobacter baumannii is a major cause of such infections and strains have recently emerged which are resistant even to the "..
  24. Type VI Protein Secretion in an Emerging Multidrug-Resistant Pathogen
    Edward Geisinger; Fiscal Year: 2013
    ..A leading agent of such infections is the bacterium Acinetobacter baumannii. This microbe causes invasive infections, including pneumonia and sepsis, that in recent years have ..
  25. Interruption of Signaling-Mediated Bacterial Persistent Infections
    Laurence G Rahme; Fiscal Year: 2013
    ..aeruginosa in human infections and similarly form AT/P cells (i.e. Acinetobacter baumannii, Klebsiella pneumoniae, and Burkholderia species) will be tested in mono- and polymicrobial planktonic ..
  26. Evolution of multidrug resistance in Acinetobacter baumannii
    Mark D Adams; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The emergence of multidrug resistance (MDR) in Acinetobacter baumannii has resulted in the designation of this Gram negative bacterium as a priority in Infectious Diseases...
  27. Class D carbapenemases: defining the role of carbapenem conformational changes
    David A Leonard; Fiscal Year: 2012
    ..Class D ? -lactamases in particular are emerging in problematic Gram-negative species such as Acinetobacter baumannii, and they pose a serious threat to the use of the four clinically-approved carbapenems: imipenem, ..
  28. Patient-Oriented Research on Hospital-Acquired Pathogens
    Alan R Hauser; Fiscal Year: 2013
    ..strains are more virulent than others will now be applied to another hospital-acquired pathogen: Acinetobacter baumannii. Accessory genomic elements (genetic material found in some strains but not in others) will be identified ..
  29. Epidemiology of Acinetobacter baumannii: An Emerging Nosocomial Pathogen
    Kerri Thom; Fiscal Year: 2013
    ..Dr. Thom proposes to study the hospital epidemiology of Acinetobacter baumannii. This organism has emerged as an important cause of nosocomial infections due to a rising incidence, ..
  30. Genetic determinants of antimicrobial peptide resistance in Gram negative bacteri
    Hyunwoo Lee; Fiscal Year: 2010
    ..only antibiotic to which multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii remain susceptible...
  31. Novel Antibacterials Targeting Gram-negative Nonfermenters
    Michelle M Butler; Fiscal Year: 2010
    ..of the growth of Gram-negative bacterial species, including such Gram-negative nonfermenters as Acinetobacter baumannii, Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia...
  32. Analysis of Novel Acinetobacter baumannii Adhesins
    Anthony A Campagnari; Fiscal Year: 2013
    DESCRIPTION (provided by applicant: Acinetobacter baumannii is a Gram-negative bacillus best known for causing health-care associated infections. Over the past decade infections with A...
  33. Epidemiology of emerging pathogens among hospitalizeds patients
    Anthony D Harris; Fiscal Year: 2013
    DESCRIPTION (provided by investigator): Acinetobacter baumannii has emerged from an organism of questionable pathogenicity to an infectious agent of importance to hospitals worldwide causing increased patient morbidity and mortality...
  34. Funtion of Uncharacterized Genes of Acinetobacter baumanii
    Samuel I Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acinetobacter baumannii (Ab) is an emerging pathogen that causes primary and opportunistic infections, and is a serious concern in the hospital and battlefield setting...
  35. High-Throughput Identification of RNA polymerase inhibitors in vivo
    Robert Landick; Fiscal Year: 2006
    ..in the US and globally, and veterans of the Iraq war are returning with untreatable infections of Acinetobacter baumannii. RNA polymerase is a proven drug target and must be fully exploited in the quest for new antibiotics...
  36. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  37. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  38. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  39. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  40. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. IRON UPTAKE IN ACTINOBACILLUS ACTINOMYCETEMCOMITANS
    Luis Actis; Fiscal Year: 2004
    ..actinomycetemcomitans. Furthermore, these studies will lead to a better understanding of the nature of the interactions between the host and this pathogen during colonization and invasion of oral tissues. ..
  42. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  43. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  44. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  45. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  46. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..