francisella tularensis

Summary

Summary: The etiologic agent of TULAREMIA in man and other warm-blooded animals.

Top Publications

  1. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
  2. pmc Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo
    Joseph Horzempa
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 78:2607-19. 2010
  3. pmc The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence
    Jeffrey R Barker
    1South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, TX, USA
    Mol Microbiol 74:1459-70. 2009
  4. pmc Targeting QseC signaling and virulence for antibiotic development
    David A Rasko
    Department of Microbiology, University of Texas UT Southwestern Medical Center, Dallas, TX 75390, USA
    Science 321:1078-80. 2008
  5. pmc Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification
    Ingmar Janse
    National Institute for Public Health and the Environment, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    BMC Microbiol 10:314. 2010
  6. pmc Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
    Tyler K Ulland
    Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2670-4. 2010
  7. pmc The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivo
    Jennifer C Chase
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Infect Immun 78:154-67. 2010
  8. ncbi Tularemia as a biological weapon: medical and public health management
    D T Dennis
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    JAMA 285:2763-73. 2001
  9. pmc The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis
    Matthew D Dyer
    Virginia Bioinformatics Institute, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e12089. 2010
  10. pmc Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity
    Tiffany M Zarrella
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 6:e22335. 2011

Detail Information

Publications282 found, 100 shown here

  1. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
    The importance of T helper type 1 (Th1) cell immunity in host resistance to the intracellular bacterium Francisella tularensis is well established...
  2. pmc Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo
    Joseph Horzempa
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 78:2607-19. 2010
    The pathogenesis of Francisella tularensis has been associated with this bacterium's ability to replicate within macrophages. F...
  3. pmc The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence
    Jeffrey R Barker
    1South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas San Antonio, San Antonio, TX, USA
    Mol Microbiol 74:1459-70. 2009
    b>Francisella tularensis causes the human disease tularemia. F...
  4. pmc Targeting QseC signaling and virulence for antibiotic development
    David A Rasko
    Department of Microbiology, University of Texas UT Southwestern Medical Center, Dallas, TX 75390, USA
    Science 321:1078-80. 2008
    ..Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs...
  5. pmc Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification
    Ingmar Janse
    National Institute for Public Health and the Environment, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    BMC Microbiol 10:314. 2010
    ..To reduce the impact of such highly pathogenic micro-organisms, rapid and accurate diagnostic tools are needed for their detection in various samples, including environmental samples...
  6. pmc Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
    Tyler K Ulland
    Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2670-4. 2010
    The mechanisms by which the intracellular pathogen Francisella tularensis evades innate immunity are not well defined. We have identified a gene with homology to Escherichia coli mviN, a putative lipid II flippase, which F...
  7. pmc The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivo
    Jennifer C Chase
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Infect Immun 78:154-67. 2010
    b>Francisella tularensis is a Gram-negative bacterium that causes acute, lethal disease following inhalation. We have previously shown that viable F...
  8. ncbi Tularemia as a biological weapon: medical and public health management
    D T Dennis
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    JAMA 285:2763-73. 2001
    ..The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population...
  9. pmc The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis
    Matthew D Dyer
    Virginia Bioinformatics Institute, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e12089. 2010
    Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category A priority pathogens for ..
  10. pmc Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity
    Tiffany M Zarrella
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 6:e22335. 2011
    The gram-negative bacterium Francisella tularensis survives in arthropods, fresh water amoeba, and mammals with both intracellular and extracellular phases and could reasonably be expected to express distinct phenotypes in these ..
  11. ncbi Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue Albany, NY 12208, USA
    J Immunol 179:532-9. 2007
    The role of Abs in protection against respiratory infection with the intracellular bacterium Francisella tularensis is not clear...
  12. ncbi Modulation of biogenesis of the Francisella tularensis subsp. novicida-containing phagosome in quiescent human macrophages and its maturation into a phagolysosome upon activation by IFN-gamma
    Marina Santic
    Department of Microbiology and Immunology, Room 316, University of Louisville College of Medicine, 319 Abraham Flexner Way 55A, Louisville, KY 40202, USA
    Cell Microbiol 7:957-67. 2005
    b>Francisella tularensis is a highly virulent facultative intracellular pathogen that has been categorized as a class A bioterrorism agent, and is classified into four subsp, tularensis, holarctica, mediasiatica and novicida...
  13. pmc The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Immunol 11:385-93. 2010
    b>Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F...
  14. pmc Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis
    James C Charity
    Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 3:e84. 2007
    The MglA protein is the only known regulator of virulence gene expression in Francisella tularensis, yet it is unclear how it functions. F. tularensis also contains an MglA-like protein called SspA...
  15. pmc Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophages
    Jessica A Edwards
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 156:327-39. 2010
    The intracellular bacterium Francisella tularensis ensures its survival and proliferation within phagocytes of the infected host through phagosomal escape and cytosolic replication, to cause the disease tularemia...
  16. pmc Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication
    Claire Checroun
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:14578-83. 2006
    ..Here, we detail in murine primary macrophages the intracellular life cycle of Francisella tularensis, a highly infectious bacterium that survives and replicates within mammalian cells...
  17. pmc Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages
    Daniel L Clemens
    Division of Infectious Diseases, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1688, USA
    Infect Immun 72:3204-17. 2004
    b>Francisella tularensis, the agent of tularemia, is an intracellular pathogen, but little is known about the compartment in which it resides in human macrophages. We have examined the interaction of a recent virulent clinical isolate of F...
  18. pmc Global transcriptional response to spermine, a component of the intramacrophage environment, reveals regulation of Francisella gene expression through insertion sequence elements
    Paul E Carlson
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Bacteriol 191:6855-64. 2009
    Tularemia is caused by the category A biodefense agent Francisella tularensis. This bacterium is associated with diverse environments and a plethora of arthropod and mammalian hosts. How F...
  19. pmc Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development
    Roger D Pechous
    Center for Biopreparedness and Infectious Disease, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Microbiol Mol Biol Rev 73:684-711. 2009
    b>Francisella tularensis is a facultative intracellular gram-negative pathogen and the etiological agent of the zoonotic disease tularemia...
  20. pmc MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages
    Linda Bönquist
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    Infect Immun 76:3502-10. 2008
    The Francisella tularensis live vaccine strain (LVS), in contrast to its iglC mutant, replicates in the cytoplasm of macrophages. We studied the outcome of infection of the murine macrophagelike cell line J774A...
  21. ncbi Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer
    Shalini Thakran
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3751-60. 2008
    The innate immune response to Francisella tularensis is primarily mediated by TLR2, though the bacterial products that stimulate this receptor remain unknown...
  22. pmc A conserved alpha-helix essential for a type VI secretion-like system of Francisella tularensis
    Jeanette E Bröms
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    J Bacteriol 191:2431-46. 2009
    b>Francisella tularensis harbors genes with similarity to genes encoding components of a type VI secretion system (T6SS) recently identified in several gram-negative bacteria...
  23. pmc IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS
    Jeanette E Bröms
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    Infect Immun 79:3683-96. 2011
    The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia, a disease intimately associated with the multiplication of the bacterium within host macrophages...
  24. ncbi Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic back
    Wangxue Chen
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
    Vaccine 21:3690-700. 2003
    ..efficacy of potential novel vaccines, the present study examined the ability of the live vaccine strain of Francisella tularensis (F...
  25. pmc IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis
    Timothy J Bauler
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites Rocky Mountain Laboratories National Institute of Allergy and Infectious Disease National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 187:1845-55. 2011
    ..is a strategy used by many viral and bacterial pathogens, including virulent strains of the bacterium Francisella tularensis, to enable colonization and infection in susceptible hosts. In this study, we demonstrated that virulent F...
  26. pmc Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
    Hua Shen
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 5:e13349. 2010
    b>Francisella tularensis is a facultative intracellular bacterial pathogen and the etiological agent of tularemia. The subspecies F...
  27. ncbi Francisella tularensis: unravelling the secrets of an intracellular pathogen
    Petra C F Oyston
    Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 57:921-30. 2008
    b>Francisella tularensis has been recognized as the causative agent of tularaemia for almost a century. Since its discovery in 1911, it has been shown to infect a wide range of hosts, including humans...
  28. pmc Survival and growth of Francisella tularensis in Acanthamoeba castellanii
    Hadi Abd
    Swedish Defence Research Agency, SE 901 82 Umea, Sweden
    Appl Environ Microbiol 69:600-6. 2003
    b>Francisella tularensis is a highly infectious, facultative intracellular bacterium which causes epidemics of tularemia in both humans and mammals at regular intervals...
  29. pmc Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism
    Kari Ann Shirey
    Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:4159-67. 2008
    b>Francisella tularensis (Ft), the causative agent of tularemia, elicits a potent inflammatory response early in infection, yet persists within host macrophages and can be lethal if left unchecked...
  30. ncbi Francisella tularensis inhibits Toll-like receptor-mediated activation of intracellular signalling and secretion of TNF-alpha and IL-1 from murine macrophages
    Max Telepnev
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, Umea, Sweden
    Cell Microbiol 5:41-51. 2003
    ..We show that Francisella tularensis, an intracellular pathogen, is capable of inhibiting this macrophage response...
  31. pmc Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages
    Stephen R Lindemann
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, USA
    Infect Immun 79:581-94. 2011
    b>Francisella tularensis is capable of rampant intracellular growth and causes a potentially fatal disease in humans...
  32. ncbi Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis
    Max Tze Han Huang
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
    J Immunol 185:5476-85. 2010
    b>Francisella tularensis is a facultative intracellular pathogen and potential biothreat agent. Evasion of the immune response contributes to the extraordinary virulence of this organism although the mechanism is unclear...
  33. pmc Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production
    Amanda A Melillo
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 285:27553-60. 2010
    b>Francisella tularensis is the etiologic agent of the highly infectious animal and human disease tularemia...
  34. pmc Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways
    Leah E Cole
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 180:6885-91. 2008
    The macrophage proinflammatory response to Francisella tularensis (Ft) live vaccine strain (LVS) was shown previously to be TLR2 dependent...
  35. pmc Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages
    Leah E Cole
    Department of Microbiology and Immunology, University of Maryland, Baltimore, 660 West Redwood Street, Room 324, Baltimore, MD 21201, USA
    Infect Immun 75:4127-37. 2007
    b>Francisella tularensis, an aerobic, non-spore-forming, gram-negative coccobacillus, is the causative agent of tularemia. We reported previously that F...
  36. pmc Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG
    Helena Lindgren
    Department of Clinical Microbiology, Clinical Bacteriology, Umea University, SE 901 85 Umea, Sweden
    Infect Immun 75:1303-9. 2007
    b>Francisella tularensis is a facultative intracellular bacterial pathogen capable of proliferating within host macrophages...
  37. ncbi Vaccines against Francisella tularensis
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, On K1C 2M7, Canada
    Ann N Y Acad Sci 1105:325-50. 2007
    b>Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century...
  38. ncbi Phylogenetic analysis of the Francisella-like endosymbionts of Dermacentor ticks
    Glen A Scoles
    USDA ARS, Animal Disease Research Unit, Washington State University, Pullman, WA 99164, USA
    J Med Entomol 41:277-86. 2004
    Bacterial endosymbionts with significant homology to Francisella tularensis (gamma-proteobacteria) have been described from at least five species of ticks in three different genera, including two North American Dermacentor species [D...
  39. pmc Identification of an essential Francisella tularensis subsp. tularensis virulence factor
    Aiping Qin
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Infect Immun 77:152-61. 2009
    b>Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose intracellular pathogen that is able to escape from the phagosome and replicate in the cytosol...
  40. ncbi Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Rev 225:244-55. 2008
    b>Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries...
  41. pmc Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor
    Grant S Schulert
    Inflammation Program and Department of Microbiology, University of Iowa, 2501 Crosspark Rd, Coralville, 52241, USA
    J Leukoc Biol 80:563-71. 2006
    b>Francisella tularensis (Ft) is a Gram-negative bacterium and the causative agent of tularemia...
  42. pmc Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity
    C M Bosio
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics, Evaluation, and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    Infect Immun 69:194-203. 2001
    ..not associated with antibody production, in protection against lethal secondary infection of mice with Francisella tularensis live vaccine strain (LVS)...
  43. pmc A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 183:4593-600. 2009
    ..In disease mediated by Francisella tularensis, Ab can effectively protect against infections with attenuated strains, for example, LVS, but not virulent ..
  44. pmc Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen
    Par Larsson
    Division of CBRN Defence and Security, Swedish Defence Research Agency, Umea, Sweden
    PLoS Pathog 5:e1000472. 2009
    b>Francisella tularensis is a potent mammalian pathogen well adapted to intracellular habitats, whereas F. novicida and F. philomiragia are less virulent in mammals and appear to have less specialized lifecycles...
  45. ncbi Cell biology and molecular ecology of Francisella tularensis
    Marina Santic
    Department of Microbiology and Parasitology, Medical Faculty, Brace Branchetta 20, University of Rijeka, Rijeka, Croatia
    Cell Microbiol 12:129-39. 2010
    b>Francisella tularensis is a highly infectious intracellular bacterium that causes the fulminating disease tularemia, which can be transmitted between mammals by arthropod vectors. Genomic studies have shown that the F...
  46. pmc Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases
    PAUL S KEIM
    The Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Nat Rev Microbiol 7:813-21. 2009
    ..This Review describes the distributions of the bacteria that cause anthrax, plague and tularaemia and investigates the forces that created clonal structures in these species...
  47. ncbi Tularemia vaccines: recent developments and remaining hurdles
    J Wayne Conlan
    National Research Council, Institute for Biological Sciences, Ottawa, Ontario, Canada
    Future Microbiol 6:391-405. 2011
    b>Francisella tularensis subsp. tularensis is a facultative intracellular bacterial pathogen of humans and other mammals. Its inhaled infectious dose is very low and can result in very high mortality. Historically, subsp...
  48. pmc Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge
    Leah E Cole
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    J Leukoc Biol 90:787-97. 2011
    ..e., production of Ft-LPS-specific antibody, as well as TLR-mediated macrophage activation, to fully control Francisella infection...
  49. ncbi Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- depende
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ont, Canada K1A 0R6
    Vaccine 23:2477-85. 2005
    b>Francisella tularensis is an extremely virulent facultative intracellular bacterial pathogen of many mammalian species including mice and humans in which it causes a spectrum of disease collectively called tularemia...
  50. pmc Environmental adaptation of Francisella tularensis
    Karsten R O Hazlett
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Microbes Infect 11:828-34. 2009
    Concerns over weaponizable bacteria have recently prompted considerable interest in Francisella tularensis (Ft)...
  51. pmc Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice
    Seth A Faith
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh Pittsburgh, PA, USA
    Front Cell Infect Microbiol 2:126. 2012
    In refining methodology to develop a mouse model for inhalation of Francisella tularensis, it was noted that both relative humidity and growth media impacted the aerosol concentration of the live vaccine strain (LVS) of F. tularensis...
  52. pmc TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    Fabio Martinon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Immunol 11:411-8. 2010
    ..resulted in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis. Our findings identify an unsuspected critical function for XBP1 in mammalian host defenses.
  53. pmc Development and comparison of two assay formats for parallel detection of four biothreat pathogens by using suspension microarrays
    Ingmar Janse
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS ONE 7:e31958. 2012
    ..for sensitive and specific detection of the biothreat pathogens Bacillus anthracis, Yersinia pestis, Francisella tularensis and Coxiella burnetii...
  54. pmc Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis
    Luke C Kingry
    Rocky Mountain Regional Center of Excellence, Colorado State University, Fort Collins, CO 80523, USA
    Microbes Infect 13:261-75. 2011
    b>Francisella tularensis is a category A select agent based on its infectivity and virulence but disease mechanisms in infection remain poorly understood...
  55. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..Caspase-1 activation in response to intracellular pathogen Francisella tularensis also required AIM2. Immunofluorescence microscopy of macrophages infected with F...
  56. ncbi Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response
    Matthew D Woolard
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:2065-74. 2007
    b>Francisella tularensis is a highly infectious bacterial pathogen, and is likely to have evolved strategies to evade and subvert the host immune response. In this study, we show that F...
  57. pmc Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    PLoS Pathog 8:e1002587. 2012
    Pulmonary Francisella tularensis and Burkholderia pseudomallei infections are highly lethal in untreated patients, and current antibiotic regimens are not always effective...
  58. pmc An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Vaccine 26:5276-88. 2008
    Vaccination of mice with Francisella tularensis live vaccine strain (LVS) mutants described so far have failed to induce protection in C57BL/6 mice against challenge with the virulent strain F. tularensis SchuS4...
  59. ncbi Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 5:135-42. 2003
    The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS)...
  60. pmc Whole genome single nucleotide polymorphism based phylogeny of Francisella tularensis and its application to the development of a strain typing assay
    Gagan A Pandya
    Pathogen Functional Genomics Resource Center, J Craig Venter Institute, Rockville, MD 20850, USA
    BMC Microbiol 9:213. 2009
    A low genetic diversity in Francisella tularensis has been documented. Current DNA based genotyping methods for typing F. tularensis offer a limited and varying degree of subspecies, clade and strain level discrimination power...
  61. pmc Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia
    Mark A Miller
    The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e31359. 2012
    ..In this report we have used the murine model of tularemia, with Francisella tularensis live vaccine strain (FTLVS) infection, to evaluate the efficiency of pneumonic delivery via intranasal ..
  62. ncbi The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm
    Marina Santic
    Department of Microbiology and Immunology, Room 316, University of Louisville College of Medicine, 319 Abraham Flexner Way 55A, Louisville, KY 40202, USA
    Cell Microbiol 7:969-79. 2005
    The Francisella tularensis subsp. novicida-containing phagosome (FCP) matures into a late endosome-like stage that acquires the late endosomal marker LAMP-2 but does not fuse to lysosomes, for the first few hours after bacterial entry...
  63. ncbi Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations
    Anders Sjostedt
    Department of Clinical Bacteriology, Clinical Microbiology, Umea University, SE 901 85 Umea, Sweden
    Ann N Y Acad Sci 1105:1-29. 2007
    b>Francisella tularensis has been recognized as a human pathogen for almost 100 years and is the etiological agent of the zoonotic disease tularemia...
  64. pmc Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens
    Robin Ireland
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000921. 2010
    ..Lastly, CLDC+MPF was also effective at controlling infections with Yersinia pestis, Burkholderia pseudomallei and Brucella abortus. Thus, CLDC+MPF represents a novel prophylaxis to protect against multiple, highly virulent pathogens...
  65. pmc Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody
    Gary R Klimpel
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Vaccine 26:6874-82. 2008
    The ability to protect mice against respiratory infections with virulent Francisella tularensis has been problematic and the role of antibody-versus-cell-mediated immunity controversial...
  66. pmc Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4
    Jennifer C Chase
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 303 S 4th St Hamilton, MT 59840, USA
    Infect Immun 77:180-95. 2009
    The gram-negative, facultative intracellular bacterium Francisella tularensis causes acute, lethal pneumonic disease following infection with only 10 CFU. The mechanisms used by the bacterium to accomplish this in humans are unknown...
  67. ncbi Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    K L Elkins
    Laboratory of Mycobacteria, Division of Bacterial Products, Rockville, MD 20852, USA
    J Immunol 162:2291-8. 1999
    ..well as synthetic oligonucleotides containing CpG motifs, induce protection against large lethal doses of Francisella tularensis live vaccine strain (LVS) and Listeria monocytogenes...
  68. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    ..b>Francisella tularensis is a category A intracellular mucosal pathogen...
  69. pmc Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain
    George Aperis
    Division of Infectious Diseases, Massachusetts General Hospital, Gray Jackson 504, 55 Fruit Street, Boston, MA 02114, USA
    Microbes Infect 9:729-34. 2007
    ..mellonella (Lepidoptera: Pyralidae; the greater wax moth) caterpillar by the live vaccine strain (LVS) of Francisella tularensis to develop an invertebrate host system that can be used to study F...
  70. ncbi A rapid multiplex assay for nucleic acid-based diagnostics
    Alina Deshpande
    Decision Applications Division, Mail Stop K551, Los Alamos National Laboratory, Los Alamos, NM 87545, United States
    J Microbiol Methods 80:155-63. 2010
    ..anthracis, Y. pestis, and F. tularensis. Combined with the ease and robustness of this assay, the results presented here show a strong potential of our assay for use in diagnostics and surveillance...
  71. pmc Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis
    Jason F Huntley
    Department of Microbiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Infect Immun 76:3664-71. 2008
    b>Francisella tularensis is a gram-negative intracellular bacterium and the causative agent of the zoonotic disease tularemia. F. tularensis is a category A select agent and thus a potential agent of bioterrorism. Whereas an F...
  72. ncbi To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils
    Lee Ann H Allen
    Inflammation Program, Department of Internal Medicine, University of Iowa, VA Medical Center, Iowa City, IA 52241, USA
    Immunol Rev 219:103-17. 2007
    ..Herein, we describe the novel strategies used by Helicobacter pylori and Francisella tularensis to disrupt neutrophil function, with a focus on assembly and activation of the nicotinamide adenine ..
  73. ncbi Francisella tularensis vaccines
    Petra C F Oyston
    Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    Vaccine 27:D48-51. 2009
    b>Francisella tularensis has attracted attention historically as a biological weapon, due to its high infectivity in aerosols, and the severity of disease in humans...
  74. ncbi Francisella tularensis: activation of the inflammasome
    David S Weiss
    Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Room D041, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1105:219-37. 2007
    b>Francisella tularensis (F. tularensis) is a facultative intracellular pathogen that causes the systemic disease tularemia. This pathogen can replicate in the cytosol of macrophages, an ability that is linked with its virulence...
  75. pmc In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, CBER FDA, Rockville, Maryland 20852, USA
    Infect Immun 70:1936-48. 2002
    ..secondary immunity to a model intracellular bacterium, we have comprehensively evaluated infection with Francisella tularensis LVS in three murine models of IL-12 deficiency...
  76. ncbi Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
    Siobhán C Cowley
    Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 184:5791-801. 2010
    ..double negative (DN) T cells are a major responding T cell subset in the lungs of mice during pulmonary Francisella tularensis live vaccine strain (LVS) infection...
  77. pmc Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112
    Joshua D Hall
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Infect Immun 76:5843-52. 2008
    b>Francisella tularensis causes systemic disease in humans and other mammals, with high morbidity and mortality associated with inhalation-acquired infection. F...
  78. ncbi Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the path
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ont, K1A OR6, Ottawa, Canada
    Vaccine 20:3465-71. 2002
    ..evaluate the efficacy of a vaccine consisting of the O-polysaccharide of the lipopolysaccharide (LPS) of Francisella tularensis chemically conjugated to bovine serum albumin...
  79. pmc Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytes
    Kee Jong Hong
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Infect Immun 75:5338-45. 2007
    The production of gamma interferon (IFN-gamma) is a key step in the protective innate immune response to Francisella tularensis. Natural killer cells and T cells in the liver are important sources of this cytokine during primary F...
  80. ncbi Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario, K1A OR6, Canada
    Microb Pathog 32:127-34. 2002
    b>Francisella tularensis is a zoonotic, facultative intracellular bacterial pathogen capable of initiating infection, tularemia, via multiple routes including dermal micro-abrasions and inhalation...
  81. ncbi Toll-like receptor 4 (TLR4) does not confer a resistance advantage on mice against low-dose aerosol infection with virulent type A Francisella tularensis
    Wangxue Chen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Room 3100, Ottawa, Ontario, Canada K1A 0R6
    Microb Pathog 37:185-91. 2004
    b>Francisella tularensis, the causative agent of tularemia, is a gram-negative facultative intracellular bacterium...
  82. pmc Detection of a possible bioterrorism agent, Francisella sp., in a clinical specimen by use of next-generation direct DNA sequencing
    Makoto Kuroda
    Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 50:1810-2. 2012
    Deep sequencing detected a potential bioterrorism agent, Francisella tularensis, in a human abscess sample (Iwaki-08) of unknown etiology...
  83. pmc Inhibition of AcpA phosphatase activity with ascorbate attenuates Francisella tularensis intramacrophage survival
    Steven McRae
    Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32610 3610, USA
    J Biol Chem 285:5171-7. 2010
    Acid phosphatase activity in the highly infectious intracellular pathogen Francisella tularensis is directly related with the ability of these bacteria to survive inside host cells...
  84. pmc Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain
    Jyotika Sharma
    South Texas Center for Emerging Infectious Diseases and Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Microb Pathog 51:39-47. 2011
    The virulence mechanisms of Francisella tularensis, the causative agent of severe pneumonia in humans and a CDC category A bioterrorism agent, are not fully defined...
  85. pmc Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia
    Anthony J Hickey
    Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
    Vaccine 29:6941-7. 2011
    b>Francisella tularensis is a highly pathogenic gram negative bacterium that infects multiple sites in a host, including the skin and the respiratory tract, which can lead to the onset of a deadly disease with a 50% mortality rate...
  86. pmc Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensis
    Shite Sebastian
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Vaccine 27:597-605. 2009
    ..vaccine that, when administered to mice, conferred protection against highly virulent strains of Francisella tularensis by stimulating both arms of the immune system. Our earlier studies with Ft...
  87. pmc Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs
    Rebecca V Anderson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S, 4th Street, Hamilton, MT 59840, USA
    Vaccine 28:6562-72. 2010
    Protection against the intracellular bacterium Francisella tularensis within weeks of vaccination is thought to involve both cellular and humoral immune responses...
  88. pmc A two-component Kdo hydrolase in the inner membrane of Francisella novicida
    Jinshi Zhao
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Mol Microbiol 78:820-36. 2010
    Lipid A coats the outer surface of the outer membrane of Gram-negative bacteria. In Francisella tularensis subspecies novicida lipid A is present either as the covalently attached anchor of lipopolysaccharide (LPS) or as free lipid A...
  89. pmc Toll-like receptor 3 agonist protection against experimental Francisella tularensis respiratory tract infection
    Richard B Pyles
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0436, USA
    Infect Immun 78:1700-10. 2010
    We investigated whether Toll-like receptor 3 (TLR3) stimulation would protect the host from inhaled Francisella tularensis. TLR3 is expressed by respiratory epithelial cells and macrophages and can be activated by a synthetic double-..
  90. pmc Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humans
    H M El Sahly
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
    Vaccine 27:4905-11. 2009
    We evaluated the safety, reactogenicity and immunogenicity of escalating doses of a new Francisella tularensis Live Vaccine Strain (LVS) lot by scarification (SCAR) or subcutaneously (SQ) in humans...
  91. pmc Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS
    Roberto De Pascalis
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Rockville, Maryland, United States of America
    PLoS Pathog 8:e1002494. 2012
    ..to explore development of clinically useful correlates of protection for intracellular bacteria, using Francisella tularensis as an experimental model. F...
  92. ncbi Ecoepidemiology of tularemia in the southcentral United States
    Rebecca J Eisen
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 78:586-94. 2008
    ..The study shows the potential for research on tularemia ecoepidemiology and highlights the need for further modeling efforts based on acarologic data and more fine-scale point or zip code/census tract epidemiologic data...
  93. pmc Coexistence of pathogens in host-seeking and feeding ticks within a single natural habitat in Central Germany
    Jan Franke
    Department of Food and Environmental Hygiene, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 29, 07743 Jena, Germany
    Appl Environ Microbiol 76:6829-36. 2010
    ..the presence of Lyme disease borreliae, Anaplasma phagocytophilum, spotted fever group (SFG) rickettsiae, Francisella tularensis, and babesiae. Altogether, 20.1% of the 680 ticks examined carried at least one pathogen...
  94. pmc Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro
    Karsten R O Hazlett
    Center for Immunology and Microbial Disease, Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
    Infect Immun 76:4479-88. 2008
    The intracellular bacterium Francisella tularensis survives in mammals, arthropods, and freshwater amoeba...
  95. ncbi Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    Edward A Medina
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Immunol 185:7562-72. 2010
    An inadequate innate immune response appears to contribute to the virulence of Francisella tularensis following pulmonary infection...
  96. pmc A Francisella tularensis locus required for spermine responsiveness is necessary for virulence
    Brian C Russo
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Infect Immun 79:3665-76. 2011
    Tularemia is a debilitating febrile illness caused by the category A biodefense agent Francisella tularensis. This pathogen infects over 250 different hosts, has a low infectious dose, and causes high morbidity and mortality...
  97. pmc Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4
    Jyothi M Ketavarapu
    South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas, San Antonio, TX 78249, USA
    Proc Natl Acad Sci U S A 105:9313-8. 2008
    b>Francisella tularensis is an intracellular, Gram-negative bacterium that is the causative agent of pulmonary tularemia. The pathogenesis and mechanisms related to innate resistance against F. tularensis are not completely understood...
  98. pmc Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization
    J Wayne Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Ontario K1A 0R6, Canada
    Vaccine 28:1824-31. 2010
    b>Francisella tularensis subspecies tularensis is a highly virulent facultative intracellular pathogen of humans and a potential biological weapon. A live vaccine strain, F...
  99. pmc Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis
    Leonardo Sorci
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:3083-8. 2009
    ..However, a comparative genome analysis of Francisella tularensis allowed us to predict the existence of an alternative route of NAD synthesis in this category A priority ..
  100. ncbi Short report: time course of hematogenous dissemination of Francisella tularensis A1, A2, and Type B in laboratory mice
    Rebecca J Eisen
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 80:259-62. 2009
    ..In the United States, human tularemia infections are caused by Francisella tularensis subspecies tularensis (Type A, clades A1 and A2) or F. tularensis subspecies holarctica (Type B)...
  101. pmc Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling
    Leah E Cole
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    J Leukoc Biol 87:275-81. 2010
    ..Taken together, these data suggest that prolonging or enhancing the interaction between TLR2 and its agonist overcomes the "bridging" function ascribed previously to TIRAP...

Research Grants68

  1. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Tularemia is a potentially fatal zoonosis of humans caused by the facultative intracellular bacterium, Francisella tularensis (Ft)...
  2. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..funding we have discovered serodiagnostic antigens for 12 NIAID priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia ..
  3. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..fever;Rickettsia sibirica causing North Asian tick typhus;Rickettsia conori causing Boutenneuse fever;Francisella tularensis causing tularemia in humans;and pathogens causing anaplasmosis, babesioses, and theileriosis in animals...
  4. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that cause hemorrhagic fevers (VHFs)...
  5. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
    ..Tularemia is a potentially fatal zoonosis of humans caused by the facultative intracellular bacterium, Francisella tularensis, and inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue ..
  6. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..De Groot, A) PROJECT 1 In the context of this proposal, we will use pre-existing defined epitopes for Francisella tularensis (FT), and using the core TRIAD vaccine design toolkit, define new epitopes for Burkholderia pseudomallei (..
  7. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..of the current application, supporting efforts on understanding how Yersinia pestis, Salmonella enterica, Francisella tularensis, Chlamydia psiticai, and Strep...
  8. Isolation of new phage enzymes to kill B. anthracis
    Vincent A Fischetti; Fiscal Year: 2013
    ..but that of other Category A biological agents with extended soil phases, like Yersinia pestis and Francisella tularensis, which also have extensive environmental phage systems...
  9. Functional analysis of the Francisella capBCA gene locus
    Jing Ren Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Francisella tularensis, the causative agent of tularemia, is a Gram-negative facultative intracellular bacterium. Because of its extreme infectivity, high virulence, and ease of dissemination, F...
  10. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    ..Using a transposon mutant library of Francisella tularensis subsp. novicida, we established that F...
  11. Nanoscale Optical Fiber Biosensor Assays for Detection of Category A and B Select
    Thomas J Inzana; Fiscal Year: 2010
    ..and rapid nanoscale optical fiber biosensors for the diagnosis of the Category A and B select agents Francisella tularensis, Burkholderia mallei, and B...
  12. Control of virulence gene expression in Francisella tularensis
    Simon L Dove; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis, the aetiological agent of tularemia, is one of the most infectious bacterial pathogens currently known and a NIAID category A priority pathogen because of its potential for use ..
  13. Francisella tularensis Interactions with Airway Epithelial Cells
    THOMAS KAWULA; Fiscal Year: 2009
    ..3 R56 AI069339-01A2 ABSTRACT Francisella tularensis is a zoonotic bacterial pathogen that causes fatal infections in hundreds of different animal species...
  14. Development of a Novel Lead Series Against Category A &B Bacterial Pathogens
    Terry L Bowlin; Fiscal Year: 2013
    ..of Gram-negative bacterial species, including a number of Category A and B agents such as Yersinia pestis, Francisella tularensis, Burkholderia mallei and pseudomallei...
  15. Modulation of host innate immune response by Francisella tularensis
    Chandra Shekhar Bakshi; Fiscal Year: 2013
    ..antioxidants in the modulation of host's innate immune response using a category A select agent, Francisella tularensis (Ft) SchuS4 as a model...
  16. Francisella - ATII interactions in respiratory tularemia
    Thomas C Zahrt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant : ABS Francisella tularensis (Ft) is a Gram-negative facultative intracellular pathogen and the causative agent of tularemia, a disease associated with high morbidity and mortality in humans...
  17. Molecular Basis of CD1d1 and Natural T Cell Function
    Sebastian Joyce; Fiscal Year: 2013
    ..this goal, we have made significant new advances on the role of mouse iNKT cells in host response to Francisella tularensis (Ft). Ft subspp. tularensis, a Category A agent and potential bioweapon, causes lethal tularemia in people...
  18. Novel antiobiotic development for biodefense
    Michael E Johnson; Fiscal Year: 2010
    Bacillus anthracis, Francisella tularensis and Yersinia pestis, the causative agents for anthrax, tularemia and plague, respectively, are all classed as Category A agents due to their potential use in bioterrorism and biowarfare...
  19. Preclinical Development of a Tularemia Vaccine
    Jason F Huntley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis is a Gram-negative intracellular bacterium capable of causing fatal systemic disease (tularemia) in a number of mammals, including humans...
  20. Virulence Factors of Francisella tularensis
    Barbara J Mann; Fiscal Year: 2010
    ..Program Director/Principal Investigator (Last, First, Middle): Mann, Barbara J. 1 R21 AI073385-01A1 ABSTRACT Francisella tularensis is a highly efficient zoonotic pathogen that is able to establish a virulent infection with 10 organisms ..
  21. IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Laurel L Lenz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The category A intracellular bacterial pathogen Francisella tularensis, the category B bacterium Listeria monocytogenes, Mycobacterium tuberculosis, and numerous other important human intracellular ..
  22. An Animal Biosafety Level 3 Laboratory for Stony Brook University
    Samuel L Stanley; Fiscal Year: 2010
    ..controlled-access facility for research involving laboratory animals and studies with the Select Agents Francisella tularensis and Yersinia pestis (both CDC Category A);Mycobacterium tuberculosis;pathogens of unknown in vivo ..
  23. IMPDH-targeted antibiotics for select agents
    LIZBETH K HEDSTROM; Fiscal Year: 2013
    ..enzyme and the permeability of the bacteria (select agents in bold): Bacillus anthracis (Gram positive), Francisella tularensis (Gram-negative facultative intracellular), Listeria monocytogenes (Gram- positive facultative ..
  24. Immunobiology and Pathogenesis of Pulmonary Tularemia (Metzger, PD)
    Dennis W Metzger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis is classified as an NIAID Category A agent because of its extreme infectivity, ease of dissemination, and substantial capacity to cause illness and death...
  25. Development of a Rationally Attenuated Live Vaccine for Francisella tularensis
    Stefanie N Vogel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis (Ft) is a Gram negative, intracellular (macrophage-tropic) bacterium, and the etiologic agent of tularemia...
  26. Solution NMR Structure and Function of the Integral Membrane Protein DsbB
    JOHN HACKETT BUSHWELLER; Fiscal Year: 2013
    ..coli virulence functions will be assessed. Aim 3: Structure determination of Francisella tularensis Group II DsbB...
  27. Francisella tularensis Pathogenesis
    Thomas H Kawula; Fiscal Year: 2010
    SUMMARY/ABSTRACT Francisella tularensis is an extremely virulent Gram negative bacterial pathogen capable of causing rapidly progressing lethal infections in literally hundreds of diverse animal species, including humans...
  28. Repression of inflammasome by Francisella tularensis
    Meenakshi Malik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis (Ft) is a gram-negative intracellular pathogen that causes a fatal disease known as tularemia...
  29. 7th International Conference on Tularemia 2012
    John T Belisle; Fiscal Year: 2012
    ..It is caused by the bacterium Francisella tularensis, one of the most infectious pathogens known. F...
  30. Regulation of Cell Death by Virulent Strains of Francisella tularensis
    Michael J Parmely; Fiscal Year: 2012
    ..applicant): Tularemia is a serious, often lethal infectious disease caused by the intracellular bacterium Francisella tularensis. A sense of the innate immune responses that protect mammalian hosts from Francisella has recently emerged ..
  31. Modulation of macrophage function by Francisella tularensis
    Chandra Shekhar Bakshi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Francisella tularensis (Ft) SchuS4 strain, the causative agent of tularemia, is amongst the most deadly potential agents of biological warfare and bioterrorism...
  32. Regulation of Gene Expression in Francisella
    Dara W Frank; Fiscal Year: 2010
    b>Francisella tularensis causes severe infections in animals and humans. This Gram-negative facultative intracellular bacterium is easily cultivated in vitro and the infectious dose of highly virulent strains is only 10 to 50 viable cells...
  33. Regulation of Innate Immunity by Pyrin Proteins
    Jonathan A Harton; Fiscal Year: 2012
    ..immune response towards a growing number of pathogens, including Bacillus anthracis, Yersinia pestis, and Francisella tularensis. Inflammasome assembly results from interaction of a pyrin containing NLR protein with ASC (apoptotic ..
  34. A unique mouse model for studying immunity to virulent Franciscella infections
    Gary R Klimpel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Francisella tularensis is a gram-negative bacterium and one of the top-priority agents ("Class A") most likely to pose a potential risk to national security...
  35. The role of mitochondrial reactive oxygen species in innate immune signaling
    DANIEL JOSEPH PRANTNER; Fiscal Year: 2013
    ..STING-dependent activation in macrophages will be examined in response to an intracellular bacterial (Francisella tularensis) or viral (Respiratory Syncytial Virus (RSV)) infection...
  36. Francisella Infection in Ticks
    Dara W Frank; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis is the etiologic agent of tularemia, a zoonotic disease maintained in the environment by rodents, lagamorphs and their ectoparasites...
  37. Role of Dsb proteins in F. tularensis virulence
    Barbara J Mann; Fiscal Year: 2010
    b>Francisella tularensis is a highly efficient zoonotic pathogen that is able to establish a virulent infection from 10 organisms or less...
  38. Pre-Exposure Prophylaxis Against Francisella tularensis
    MARCUS AARON HORWITZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis (Ft) causes tularemia, a serious and potentially fatal disease...
  39. Mechanism of Antibody-mediated Immunity against F. tularensis
    Girish S Kirimanjeswara; Fiscal Year: 2010
    ..In the case of Francisella tularensis, antibodies together with the cytokine IFN-? were shown to be critical in achieving rapid bacterial ..
  40. Development and Formulation of Broad Spectrum Antimicrobials for Biodefense
    Richard A Slayden; Fiscal Year: 2010
    ..can be used for Phase 1 clinical trials for treating the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersinia pestis...
  41. Identification of Francisella tularensis extracellular proteins expressed in vivo
    JAMES EDWARD BINA; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): The goal of this research proposal is to identify virulence factors in Francisella tularensis Schu S4. In nature, F. tularensis causes the zoonotic disease tularemia. F...
  42. Development of TP-217 as a highly efficacious, broad-spectrum antibiotic for the
    ANNE KATHLEEN RADCLIFF; Fiscal Year: 2013
    ..To substantiate this, the proposed work will also investigate the efficacy of TP-271 against Francisella tularensis in mice...
  43. Dual Action Inhibitors of Gyrase Beta and Histidine Kinases as Broad-Spectrum Ant
    Peter B Madrid; Fiscal Year: 2010
    ..N lAID Category A pathogen, Francisella tularensis. The specific aims are to: 1...
  44. Pre-Exposure Prophylaxis Against Francisella tularensis
    MARCUS AARON HORWITZ; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Francisella tularensis (Ft) causes tularemia, a serious and potentially fatal disease...
  45. Mechanism of Antibody-mediated Immunity against F. tularensis
    Girish S Kirimanjeswara; Fiscal Year: 2012
    ..In the case of Francisella tularensis, antibodies together with the cytokine IFN-[unreadable] were shown to be critical in achieving rapid ..
  46. AI-3 Inhibitors as treatment for bacterial infections
    Vanessa Sperandio; Fiscal Year: 2012
    ..coli and Salmonella species causing numerous food poisoning syndromes, as well as Francisella tularensis, the causative agent of tularemia by interfering with quorum sensing...
  47. Inhaled Aminoglycoside Formulafor Plague and Tularemia
    James Talton; Fiscal Year: 2005
    ..treatment of aerosol exposure of the Category A bioterrorism agents pneumonic Yersina pestis (plague) and Francisella tularensis (tularemia)...
  48. Modulation of host defenses by the bacterial pathogen Francisella tularensis
    David S Weiss; Fiscal Year: 2011
    b>Francisella tularensis is a highly infectious intracellular bacterial pathogen that causes tularemia, a potentially life-threatening disease in humans...
  49. Criteria-Directed Vaccine Generation Via Ag Mimicry, Adjuvancy, And APC-Targeting
    Timothy J Sellati; Fiscal Year: 2013
    ..test our hypothesis in the context of a very stringent model (respiratory infection with human-virulent Francisella tularensis [Ft]) in which we have obtained highly encouraging results with an adjuvant-free, mucosal vaccine (up to ..
  50. Advancement of New Live Attenuated F. Tularensis Type A Vaccine Strains
    Eileen M Barry; Fiscal Year: 2010
    b>Francisella tularensis is a Category A select agent that can cause severe and fatal disease in humans if an aerosol containing as few as 10-100 CFU is inhaled...
  51. Francisella tularensis invasion of human erythrocytes
    JOSEPH A HORZEMPA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis is one of the most infectious organisms as inhalation of a single bacterium can lead to a fatal disease referred to as tularemia...
  52. A novel role for the TLR signaling adaptor TRAM
    Michael T Berton; Fiscal Year: 2013
    ..In recent studies of the immune response to the Gram-negative bacterium Francisella tularensis, we have uncovered a novel signaling pathway in vivo that requires TRAM but does not appear to involve the ..
  53. Rapid Detection and Identification of Zoonotic Pathogens
    John Dunn; Fiscal Year: 2007
    ..sequence-based systems to detect zoonotic and/or vector-borne biothreat agents such as Yersinia pestis, Francisella tularensis, Rickettsia ricketsii and other human pathogens such as Ehrlichia and Babesia species...
  54. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularemia), and a group of RNA viruses that cause hemorrhagic fevers (VHFs, e.g., Ebola)...
  55. Mechanisms of Francisella Virulence
    Barbara J Mann; Fiscal Year: 2011
    b>Francisella tularensis subspecies tularensis, also known as type A Francisella, is a category A priority pathogen for Biodefense Research. It causes a potentially life-threatening disease called tularemia. F...
  56. Francisella tularensis Pathogenesis
    Thomas H Kawula; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Francisella tularensis is an extremely virulent Gram negative, facultative intracellular bacterial pathogen capable of causing rapidly progressing lethal infections in literally hundreds of diverse ..
  57. Multiplexed POC Diagnostic System for Bio-Threat Agents
    GEORGE SIGAL; Fiscal Year: 2005
    ..serological tests include the following ten threat agents: Bacillus anthracis (BA), Yersinia pestis (YP), Francisella tularensis (FT), Coxiella burnetii (Q Fever), Brucellosis ssp, vaccinia virus, Venezuelan Equine Encephalitis (VEE), ..
  58. Applicability of smartDNA Rapid Detection of Priority Agents in Food
    RICHARD BLIDNER; Fiscal Year: 2009
    ..for use by first responders for the detection of multiple bio-terrorism agents (Bacillus anthracis, Francisella tularensis and Yersinia pestis)...
  59. Automated Simultaneous Detection of Bioterrorism Agents
    David Ecker; Fiscal Year: 2005
    ..false positives, key biological weapons agents (spiked) such as Bacillus anthracis, Yersinia pestis, and Francisella tularensis. TIGER has also detected and strain-typed other medically important bacteria and viruses including ..
  60. Sensitive Diagnosis of Biowarfare Agents on a Microchip
    Greg Collins; Fiscal Year: 2006
    ..coli toxin, Brucella abortus, Bacillus anthracis, Francisella tularensis and Salmonella...
  61. Proximal determinants of risk for tularemia outbreaks
    Sam Telford; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Although much is known about the biology of Francisella tularensis, the factors that regulate its natural prevalence remain un-described...
  62. Protective and pathogenic B cell epitopes in Francisella tularensis
    Jacqueline Sharon; Fiscal Year: 2012
    ..This contract will identify epitope from Francisella tularensis bacterium
  63. Protective and pathogenic B cell epitopes in Francisella tularensis
    Jacqueline Sharon; Fiscal Year: 2013
    ..This contract will identify epitope from Francisella tularensis bacterium
  64. Protective and pathogenic B cell epitopes in Francisella tularensis
    Jacqueline Sharon; Fiscal Year: 2011
    ..This contract will identify epitope from Francisella tularensis bacterium
  65. Protective and pathogenic B cell epitopes in Francisella tularensis
    Jacqueline Sharon; Fiscal Year: 2009
    ..This contract will identify epitope from Francisella tularensis bacterium
  66. Protective and pathogenic B cell epitopes in Francisella tularensis
    Jacqueline Sharon; Fiscal Year: 2010
    ..This contract will identify epitope from Francisella tularensis bacterium
  67. An Oral Vaccine Against Multiple Biowarfare Agents
    KARL KLOSE; Fiscal Year: 2004
    ..Two such bacterial agents, Bacillus anthracis and Francisella tularensis, can be easily spread by aerosolization causing a high level of mortality, and are therefore considered to ..
  68. Novel Class of Phospholipases-Molecular Pathogenesis
    Michael Vasil; Fiscal Year: 2007
    ..aeruginosa (2), Mycobacterium tuberculosis (4), Francisella tularensis (1), Burkholderia pseudomallei and mallei (3 each) and Bordetella pertussis (1)...