coxiella burnetii

Summary

Summary: A species of gram-negative bacteria that grows preferentially in the vacuoles of the host cell. It is the etiological agent of Q FEVER.

Top Publications

  1. ncbi Experimental Coxiella burnetii infection in pregnant goats: excretion routes
    Nathalie Arricau Bouvery
    Pathologie Infectieuse et Immunologie, INRA, Tours Nouzilly, 37380 Nouzilly, France
    Vet Res 34:423-33. 2003
  2. ncbi Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
    Daniel E Voth
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Microbiol 9:829-40. 2007
  3. ncbi Q Fever
    Emmanouil Angelakis
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Vet Microbiol 140:297-309. 2010
  4. pmc Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors
    Xiaoxiao Pan
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 320:1651-4. 2008
  5. ncbi Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
  6. pmc Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii
    Chen Chen
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 107:21755-60. 2010
  7. pmc Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages
    Paul A Beare
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    MBio 2:e00175-11. 2011
  8. pmc Host cell-free growth of the Q fever bacterium Coxiella burnetii
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 106:4430-4. 2009
  9. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
  10. ncbi Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles
    Maximiliano G Gutierrez
    Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza, 5500, Argentina
    Cell Microbiol 7:981-93. 2005

Detail Information

Publications317 found, 100 shown here

  1. ncbi Experimental Coxiella burnetii infection in pregnant goats: excretion routes
    Nathalie Arricau Bouvery
    Pathologie Infectieuse et Immunologie, INRA, Tours Nouzilly, 37380 Nouzilly, France
    Vet Res 34:423-33. 2003
    Q fever is a widespread zoonosis caused by Coxiella burnetii. Infected animals, shedding bacteria by different routes, constitute contamination sources for humans and the environment...
  2. ncbi Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
    Daniel E Voth
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Microbiol 9:829-40. 2007
    ..However, this is not the case of the Q fever bacterium, Coxiella burnetii. This hardy, obligate intracellular pathogen has evolved to not only survive, but to thrive, in the harshest ..
  3. ncbi Q Fever
    Emmanouil Angelakis
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Vet Microbiol 140:297-309. 2010
    Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations...
  4. pmc Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors
    Xiaoxiao Pan
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 320:1651-4. 2008
    ..We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial ..
  5. ncbi Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
    Q fever is a zoonosis caused by Coxiella burnetii. Infection with C burnetii can be acute or chronic, and exhibits a wide spectrum of clinical manifestations...
  6. pmc Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii
    Chen Chen
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 107:21755-60. 2010
    b>Coxiella burnetii is an obligate intracellular bacterial pathogen responsible for acute and chronic Q fever...
  7. pmc Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages
    Paul A Beare
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    MBio 2:e00175-11. 2011
    Central to Q fever pathogenesis is replication of the causative agent, Coxiella burnetii, within a phagolysosome-like parasitophorous vacuole (PV) in mononuclear phagocytes. C...
  8. pmc Host cell-free growth of the Q fever bacterium Coxiella burnetii
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 106:4430-4. 2009
    ..b>Coxiella burnetii, the causative agent of human Q (Query) fever, is an obligate intracellular bacterial pathogen that ..
  9. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
    Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts.
  10. ncbi Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles
    Maximiliano G Gutierrez
    Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza, 5500, Argentina
    Cell Microbiol 7:981-93. 2005
    ..b>Coxiella burnetii, the agent of Q fever in man is a Gram-negative gamma-proteobacterium which multiplies in large, acidified, ..
  11. ncbi Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
    E Botelho-Nevers
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 26:635-40. 2007
    Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis...
  12. pmc Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray
    ADAM VIGIL
    Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA
    Proteomics 10:2259-69. 2010
    Comprehensive evaluation of the humoral immune response to Coxiella burnetii may identify highly needed diagnostic antigens and potential subunit vaccine candidates...
  13. pmc Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
    Hendrik I J Roest
    Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 17:668-75. 2011
    Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the ..
  14. ncbi The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell
    Patricia S Romano
    Laboratorio de Biologia Celular y Molecular, IHEM CONICET, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo Mendoza, 5500, Argentina
    Cell Microbiol 9:891-909. 2007
    The etiologic agent of Q fever Coxiella burnetii, is an intracellular obligate parasite that develops large vacuoles with phagolysosomal characteristics, containing multiple replicating bacteria. We have previously shown that Phase II C...
  15. ncbi Q fever
    Neil R Parker
    Darling Downs Public Health Unit, Queensland Health, Australia
    Lancet 367:679-88. 2006
    ..An effective whole-cell vaccine is licensed in Australia. Live and acellular vaccines have also been studied, but are not currently licensed...
  16. ncbi Is Q fever an emerging or re-emerging zoonosis?
    Nathalie Arricau-Bouvery
    Pathologie Infectieuse et Immunologie, INRA, Centre de Tours Nouzilly, 37380 Nouzilly, France
    Vet Res 36:327-49. 2005
    Q fever is a zoonotic disease considered as emerging or re-emerging in many countries. It is caused by Coxiella burnetii, a bacterium developing spore-like forms that are highly resistant to the environment...
  17. pmc Molecular characterization of Coxiella burnetii isolates by infrequent restriction site-PCR and MLVA typing
    Nathalie Arricau-Bouvery
    INRA, Pathologie Infectieuse et Immunologie, 37380 Nouzilly, France
    BMC Microbiol 6:38. 2006
    b>Coxiella burnetii, the causative agent of Q fever, has a wide host range. Few epidemiological tools are available, and they are often expensive or not easily standardized across laboratories. In this work, C...
  18. pmc Genotypic diversity of Coxiella burnetii in the 2007-2010 Q fever outbreak episodes in The Netherlands
    Jeroen J H C Tilburg
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Clin Microbiol 50:1076-8. 2012
    The genotypic diversity of Coxiella burnetii in clinical samples obtained from the Dutch Q fever outbreak episodes of 2007-2010 was determined by using a 6-locus variable-number tandem repeat analysis panel...
  19. pmc Wind in November, Q fever in December
    Hervé Tissot-Dupont
    Unite des Rickettsies, CNRS, Faculte de Medecine, Marseille, France
    Emerg Infect Dis 10:1264-9. 2004
    Q fever, a worldwide zoonosis caused by Coxiella burnetii, can be transmitted from animal reservoirs to humans by the inhalation of infected aerosols...
  20. pmc The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication
    Kimberly L Carey
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002056. 2011
    b>Coxiella burnetii, the causative agent of human Q fever, is an intracellular pathogen that replicates in an acidified vacuole derived from the host lysosomal network...
  21. ncbi Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach
    Z Sekeyova
    Faculte de Medecine, Universite de la Mediterranee, URMITE 6236 IRD, IFR 48, 27 Boulevard Jean Moulin, 05 13385 Marseille Cedex, France
    Eur J Clin Microbiol Infect Dis 28:287-95. 2009
    Q fever is a worldwide zoonosis caused by Coxiella burnetii bacterium. Two clinical forms are present: acute Q fever and chronic disease, including endocarditis...
  22. ncbi Identification and cloning potentially protective antigens of Coxiella burnetii using sera from mice experimentally infected with Nine Mile phase I
    G Q Zhang
    Department of Medical Microbiology and Immunology, Texas A M University System Health Science Center, College Station, Texas 77843 1114, USA
    Ann N Y Acad Sci 990:510-20. 2003
    b>Coxiella burnetii is an obligate intracellular bacterium that causes acute Q fever and occasional chronic infections in humans. To determine the immunodominant antigens during infection with C...
  23. pmc Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands
    Lenny Hogerwerf
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Emerg Infect Dis 17:379-86. 2011
    ..In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled...
  24. pmc Chromosomal DNA deletions explain phenotypic characteristics of two antigenic variants, phase II and RSA 514 (crazy), of the Coxiella burnetii nine mile strain
    T A Hoover
    Bacteriology Division, USAMRIID, Ft Detrick, Frederick, Maryland 21701, USA
    Infect Immun 70:6726-33. 2002
    After repeated passages through embyronated eggs, the Nine Mile strain of Coxiella burnetii exhibits antigenic variation, a loss of virulence characteristics, and transition to a truncated lipopolysaccharide (LPS) structure...
  25. pmc The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion
    Daniel E Voth
    Coxiella Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 191:4232-42. 2009
    b>Coxiella burnetii is an obligate intracellular bacterium that directs biogenesis of a parasitophorous vacuole (PV) for replication...
  26. pmc The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates
    Daniel E Voth
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    J Bacteriol 193:1493-503. 2011
    The intracellular bacterial pathogen Coxiella burnetii directs biogenesis of a phagolysosome-like parasitophorous vacuole (PV), in which it replicates...
  27. ncbi The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii
    Gil Segal
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    FEMS Microbiol Rev 29:65-81. 2005
    ..The type-IV secretion systems were divided into two subgroups and Legionella pneumophila and Coxiella burnetii are the only two bacteria known today to utilize a type-IVB secretion system for pathogenesis...
  28. ncbi Q fever (coxiellosis): epidemiology and pathogenesis
    Zerai Woldehiwet
    Department of Veterinary Pathology, University of Liverpool, Veterinary Teaching Hospital, Leahurst, Neston, Wirral CH64 7TE, UK
    Res Vet Sci 77:93-100. 2004
    Q fever is a widespread zoonosis caused by the Gram-negative bacterium Coxiella burnetii. Aborting domestic ruminants are the main sources of human infection but the reservoir of infection is extremely wide...
  29. pmc Single-nucleotide-polymorphism genotyping of Coxiella burnetii during a Q fever outbreak in The Netherlands
    Cornelis J J Huijsmans
    Laboratory of Molecular Diagnostics, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 NL s Hertogenbosch, Netherlands
    Appl Environ Microbiol 77:2051-7. 2011
    b>Coxiella burnetii is the etiological agent of Q fever. Currently, the Netherlands is facing the largest Q fever epidemic ever, with almost 4,000 notified human cases...
  30. ncbi Q fever: a biological weapon in your backyard
    Miguel G Madariaga
    Division of Infectious Disease, Cook County Hospital, Chicago and the Section of Infectious Diseases, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Lancet Infect Dis 3:709-21. 2003
    b>Coxiella burnetii, which causes Q fever, is a highly infectious agent that is widespread among livestock around the world. Although the culture process for coxiella is laborious, large amounts of infectious material can be produced...
  31. ncbi Q Fever during pregnancy: a cause of poor fetal and maternal outcome
    Xavier Carcopino
    Service de Gynecologie Obstetrique, Hopital Nord, Chemin des Bourrely, 13915 cedex 20, Marseille, France
    Ann N Y Acad Sci 1166:79-89. 2009
    Q fever is a worldwide zoonosis caused by Coxiella burnetii. Q fever may be present as an acute or a chronic infection and can be reactivated during subsequent pregnancies...
  32. pmc Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray
    Paul A Beare
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Clin Vaccine Immunol 15:1771-9. 2008
    Q fever is a widespread zoonosis caused by Coxiella burnetii. Diagnosis of Q fever is usually based on serological testing of patient serum...
  33. ncbi Q fever in the Netherlands from 2007 to 2010
    C E Delsing
    Department of Internal Medicine Radboud Expertise Centre for Q fever, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 68:382-7. 2010
    ..Finally, the latest data on clinical presentation and diagnostic and therapeutic dilemmas of Q fever in the Netherlands are reviewed...
  34. pmc Rapid typing of Coxiella burnetii
    Heidie M Hornstra
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 6:e26201. 2011
    b>Coxiella burnetii has the potential to cause serious disease and is highly prevalent in the environment...
  35. pmc Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella
    Paul A Beare
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S 4th Street, Hamilton, MT 59840, USA
    Infect Immun 77:642-56. 2009
    Genetically distinct isolates of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in vitro infectivity/cytopathology and pathogenicity for laboratory animals. Moreover, correlations between C...
  36. ncbi Chronic Q fever: different serological results in three countries--results of a follow-up study 6 years after a point source outbreak
    Brendan Healy
    Public Health Wales, Microbiology Department, UHW Heath Park, Cardiff, Wales, United Kingdom
    Clin Infect Dis 52:1013-9. 2011
    Acute and chronic Q fever/Coxiella burnetii infection is diagnosed principally by serology. The management of patients who have serological evidence of chronic Q fever but no other manifestation of chronic infection is challenging.
  37. ncbi Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat
    Ashraf Alsaleh
    LUNAM University, ONIRIS, Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Department of Research into the Health Risk and Biotechnology of Reproduction, Nantes, France
    Comp Immunol Microbiol Infect Dis 34:355-60. 2011
    The aim of the present study was the detection and quantification of Coxiella burnetii DNA in the flushing media (oviducts and uterine horns) and genital tract tissues of non pregnant goats from 20 goats chosen at random from 86 goats ..
  38. pmc Risk factors of Coxiella burnetii (Q fever) seropositivity in veterinary medicine students
    Myrna M T de Rooij
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    PLoS ONE 7:e32108. 2012
    ..This study aimed to assess the seroprevalence of Coxiella burnetii among veterinary medicine students and to identify associated risk factors.
  39. pmc Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages
    Dario S Zamboni
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, Sao Paulo, SP 04023 062 Brazil
    Infect Immun 71:1225-33. 2003
    In most primary or continuous cell cultures infected with the Q-fever agent Coxiella burnetii, bacteria are typically sheltered in phagolysosome-like, large replicative vacuoles (LRVs)...
  40. pmc Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania
    Malavika Prabhu
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
    Clin Infect Dis 53:e8-15. 2011
    ....
  41. pmc Molecular method for the characterization of Coxiella burnetii from clinical and environmental samples: variability of genotypes in Spain
    Isabel Jado
    Laboratorio de Espiroquetas y Patógenos Especiales, Department of Bacteriology, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra, de Pozuelo km 2, 6, Majadahonda, Madrid, 28220, Spain
    BMC Microbiol 12:91. 2012
    b>Coxiella burnetii is a highly clonal microorganism which is difficult to culture, requiring BSL3 conditions for its propagation. This leads to a scarce availability of isolates worldwide...
  42. ncbi Follow-up of 686 patients with acute Q fever and detection of chronic infection
    Wim van der Hoek
    Epidemiology and Surveillance Unit, Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Infect Dis 52:1431-6. 2011
    ..Recent outbreaks in the Netherlands allowed for laboratory follow-up of a large series of patients with acute Q fever and for evaluation of test algorithms to detect chronic Q fever, a condition with considerable morbidity and mortality...
  43. ncbi Identification of risk factors of Coxiella burnetii (Q fever) infection in veterinary-associated populations in southern Taiwan
    C C Chang
    Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan
    Zoonoses Public Health 57:e95-101. 2010
    ..The purpose of this study was to determine the seroprevalence and risk factors of Coxiella burnetii infection in veterinary-associated populations in southern Taiwan...
  44. pmc The early secretory pathway contributes to the growth of the Coxiella-replicative niche
    Emanuel Martín Campoy
    Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia IHEM CONICET, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
    Infect Immun 79:402-13. 2011
    b>Coxiella burnetii is a Gram-negative obligate intracellular bacterium. After internalization, this bacterium replicates in a large parasitophorous vacuole that has features of both phagolysosomes and autophagosomal compartments...
  45. pmc Clinical and pathologic changes in a guinea pig aerosol challenge model of acute Q fever
    K E Russell-Lodrigue
    Department of Veterinary Pathobiology, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 74:6085-91. 2006
    Acute Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii and can manifest as a flu-like illness, pneumonia, or hepatitis...
  46. pmc Cloning and sequencing of Coxiella burnetii outer membrane protein gene com1
    L R Hendrix
    MicroCarb Inc, Gaithersburg, Maryland 20879
    Infect Immun 61:470-7. 1993
    ..27-kDa outer membrane-associated, immunoreactive protein was cloned from the rickettsial pathogen Coxiella burnetii. The gene, designated com1 for Coxiella outer membrane protein 1, was expressed in Escherichia coli, ..
  47. pmc Identification and characterization of an immunodominant 28-kilodalton Coxiella burnetii outer membrane protein specific to isolates associated with acute disease
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, 407 Reynolds Medical Building, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 73:1561-7. 2005
    b>Coxiella burnetii causes acute Q fever in humans and occasional chronic infections that typically manifest as endocarditis or hepatitis...
  48. ncbi Natural history of Q fever in goats
    Todd Hatchette
    The Department of Medicine, Dalhousie University, Halifax, Nova Scotia
    Vector Borne Zoonotic Dis 3:11-5. 2003
    ..The intent of this study was to determine the natural history of Coxiella burnetii infection in goats...
  49. ncbi [Abortion and stillbirth among dairy goats as a consequence of Coxiella burnetii]
    W Wouda
    GD, Postbus 9, 7400 AA Deventer
    Tijdschr Diergeneeskd 132:908-11. 2007
    ..These consequences of Coxiella burnetii infection appear to have increased during recent years in the Dutch dairy goat population...
  50. pmc Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein
    Anja Lührmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 107:18997-9001. 2010
    b>Coxiella burnetii and Legionella pneumophila are evolutionarily related pathogens with different intracellular infection strategies. C. burnetii persists within and is transmitted by mammalian hosts, whereas, L...
  51. ncbi Prevention of Coxiella burnetii shedding in infected dairy herds using a phase I C. burnetii inactivated vaccine
    Raphaël Guatteo
    Ecole Nationale Veterinaire de Nantes, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, F 44307 Nantes, France
    Vaccine 26:4320-8. 2008
    ..objective of this study was to assess the efficacy of a monovalent inactivated vaccine containing phase I Coxiella burnetii to prevent Coxiella shedding in susceptible dairy cows within infected herds in comparison to a placebo...
  52. ncbi Effect of vaccination with phase I and phase II Coxiella burnetii vaccines in pregnant goats
    Nathalie Arricau-Bouvery
    INRA, Pathologie Infectieuse et Immunologie, F 37380 Nouzilly, France
    Vaccine 23:4392-402. 2005
    ..Two months before mating, 17 goats were vaccinated subcutaneously against Coxiella burnetii with an inactivated phase I vaccine and 16 goats were vaccinated with an inactivated phase II Coxiella mixed ..
  53. pmc Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in The Netherlands
    Wim van der Hoek
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Infect Dis 11:44. 2011
    Q fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases...
  54. pmc Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds
    Elodie Rousset
    Agence Française de Sécurité Sanitaire des Aliments French Food Safety Agency AFSSA, Unité Pathologie des Ruminants Laboratory of Pathologies in Ruminants, Sophia Antipolis, France
    Appl Environ Microbiol 75:428-33. 2009
    Q fever is a zoonosis caused by Coxiella burnetii, a bacterium largely carried by ruminants and shed into milk, vaginal mucus, and feces...
  55. pmc Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons
    Paul A Beare
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    J Bacteriol 188:2309-24. 2006
    b>Coxiella burnetii, a gram-negative obligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterrorism. Distinct genomic groups of C...
  56. ncbi Goats may experience reproductive failures and shed Coxiella burnetii at two successive parturitions after a Q fever infection
    M Berri
    INRA Tours Nouzilly, Infectiologie Animale et Sante Publique, 37380 Nouzilly, France
    Res Vet Sci 83:47-52. 2007
    Q fever is a zoonosis caused by the obligate intracellular bacterium, Coxiella burnetii. Aborting domestic ruminants are the main source of human infection...
  57. ncbi Q Fever in dairy animals
    Annie Rodolakis
    INRA, UR 1282 Infectiologie Animale et Santé Publique, F 37380 Nouzilly
    Ann N Y Acad Sci 1166:90-3. 2009
    ..The number of Coxiella shed in milk is generally low. The phase I vaccine prevented abortion and greatly decreased the shedding of C. burnetii in milk...
  58. pmc Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages
    Dale Howe
    Coxiella Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:3465-74. 2010
    b>Coxiella burnetii infects mononuclear phagocytes, where it directs biogenesis of a vacuolar niche termed the parasitophorous vacuole (PV)...
  59. ncbi Developmental biology of Coxiella burnettii
    R A Heinzen
    Dept of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Trends Microbiol 7:149-54. 1999
    The obligate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to persist in the extracellular environment...
  60. ncbi Managing Q fever during pregnancy: the benefits of long-term cotrimoxazole therapy
    Xavier Carcopino
    Service de Gynecologie Obstetrique, Hopital Nord, Chemin des Bourrely, France
    Clin Infect Dis 45:548-55. 2007
    Q fever is a zoonosis caused by Coxiella burnetii. During pregnancy, it may result in obstetric complications, such as spontaneous abortion, intrauterine growth retardation, intrauterine fetal death, and premature delivery...
  61. ncbi Shedding routes of Coxiella burnetii in dairy cows: implications for detection and control
    Raphaël Guatteo
    Unit of Animal Health Management, Veterinary School and INRA, BP 40706, 44307 Nantes Cedex 03, France
    Vet Res 37:827-33. 2006
    Reliable detection of Coxiella burnetii shedders is a critical point for the control of the spread of this bacterium among animals and from animals to humans...
  62. pmc Temporal analysis of Coxiella burnetii morphological differentiation
    Sherry A Coleman
    Coxiella Pathogenesis Unit, NIAID NIH, Rocky Mountain Laboratories, 903 S 4th Street, Hamilton, MT 59840, USA
    J Bacteriol 186:7344-52. 2004
    b>Coxiella burnetii undergoes a poorly defined developmental cycle that generates morphologically distinct small-cell variants (SCV) and large-cell variants (LCV). We developed a model to study C...
  63. ncbi Q fever in humans and animals in the United States
    Jennifer H McQuiston
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vector Borne Zoonotic Dis 2:179-91. 2002
    b>Coxiella burnetii, the etiologic agent of Q fever, is a worldwide zoonotic pathogen. Although Q fever is present in the United States, little is known about its current incidence or geographic distribution in either humans or animals...
  64. ncbi Mechanisms of vaccine-induced protective immunity against Coxiella burnetii infection in BALB/c mice
    Guoquan Zhang
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    J Immunol 179:8372-80. 2007
    To elucidate the mechanisms of vaccine-induced protective immunity against Coxiella burnetii infection, we compared the protective efficacy and immunogenicity between formalin-inactivated phase I vaccine (PI-V) and phase II vaccine (PII-..
  65. pmc Identification and cloning of immunodominant antigens of Coxiella burnetii
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Infect Immun 72:844-52. 2004
    ..infection-derived antibody, mouse sera from different stages of experimental infection with various doses of Coxiella burnetii were tested by immunoblotting...
  66. pmc T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice
    Masako Andoh
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 75:3245-55. 2007
    b>Coxiella burnetii, the etiological agent of Q fever, has two phase variants. Phase I has a complete lipopolysaccharide (LPS), is highly virulent, and causes Q fever in humans and pathology in experimental animals...
  67. pmc Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands
    A de Bruin
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    Appl Environ Microbiol 77:6516-23. 2011
    Q fever, caused by Coxiella burnetii, is a zoonosis with a worldwide distribution. A large rural area in the southeast of the Netherlands was heavily affected by Q fever between 2007 and 2009...
  68. ncbi Prevalence of Coxiella burnetii infection in domestic ruminants: a critical review
    Raphaël Guatteo
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes F 44307, France
    Vet Microbiol 149:1-16. 2011
    Reliable detection of Coxiella burnetii is a critical point for the control of the spread of this zoonotic disease (Q fever), ruminants being considered as the main source for human infection as confirmed by the recent human outbreak in ..
  69. pmc Q fever among culling workers, the Netherlands, 2009-2010
    Jane Whelan
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 17:1719-23. 2011
    ..Among 517 culling workers, despite use of personal protective equipment, 17.5% seroconverted for antibodies to Coxiella burnetii. Vaccination of culling workers could be considered.
  70. ncbi Detection of Anaplasma phagocytophilum, Coxiella burnetii, Rickettsia spp., and Borrelia burgdorferi s. l. in Ticks, and wild-living animals in western and middle Slovakia
    Katarína Smetanová
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovak Republic
    Ann N Y Acad Sci 1078:312-5. 2006
    ..reticulatus), small terrestrial mammals, and game were examined by PCR for the presence of tick-borne pathogens Anaplasma phagocytophilum, Coxiella burnetii, Rickettsia spp., and Borrelia burgdorferi Sensu lato.
  71. pmc Identification of a 71-kilodalton surface-associated Hsp70 homologue in Coxiella burnetii
    A Macellaro
    Department of Microbiology, Defence Research Establishment, S 901 82 Umeå, Sweden
    Infect Immun 66:5882-8. 1998
    A Coxiella burnetii Hsp70 homologue was identified by using an acid activation in vitro system in which protein synthesis has been followed by [35S]methionine labeling, autoradiography, and immunoblotting...
  72. pmc Immunoreactive Coxiella burnetii Nine Mile proteins separated by 2D electrophoresis and identified by tandem mass spectrometry
    James R Deringer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    Microbiology 157:526-42. 2011
    b>Coxiella burnetii is a Gram-negative obligate intracellular pathogen and the causative agent of Q fever in humans. Q fever causes acute flu-like symptoms and may develop into a chronic disease leading to endocarditis...
  73. pmc Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever
    K E Russell-Lodrigue
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, Texas 77843 1114, USA
    Infect Immun 77:5640-50. 2009
    Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis...
  74. ncbi Coxiella burnetii: host and bacterial responses to infection
    David M Waag
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Vaccine 25:7288-95. 2007
    Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in ..
  75. pmc Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting
    Mischa M Jager
    Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 5200 ME s Hertogenbosch, Netherlands
    Clin Vaccine Immunol 18:963-8. 2011
    ..algorithm for acute Q fever with an enzyme-linked immunosorbent assay for immunoglobulin M antibodies to Coxiella burnetii phase II antigens (MII screen) as an initial step...
  76. ncbi Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak
    L M Kampschreur
    Division of Medicine, Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
    Epidemiol Infect 141:847-51. 2013
    ..Based on Q fever screening programmes, seroprevalence of IgG phase II antibodies to Coxiella burnetii in the JBH catchment area was 10·7% [785 tested, 84 seropositive, 95% confidence interval (CI) 8·5-12·9]...
  77. ncbi A seroepidemiological study of the risks of Q fever infection in Japanese veterinarians
    T Abe
    Second Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Eur J Epidemiol 17:1029-32. 2001
    The causative agent of Q fever, a widespread zoonotic disease, is the bacteria Coxiella burnetii. Although cases of Q fever have been documented in countries throughout the world, the prevalence of the disease in Japan is not yet known...
  78. ncbi Replication of Coxiella burnetii is inhibited in CHO K-1 cells treated with inhibitors of cholesterol metabolism
    Dale Howe
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Ann N Y Acad Sci 1063:123-9. 2005
    b>Coxiella burnetii directs the synthesis of a large parasitophorous vacuole (PV) that is required for its replication...
  79. pmc Genotyping reveals the presence of a predominant genotype of Coxiella burnetii in consumer milk products
    Jeroen J H C Tilburg
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Clin Microbiol 50:2156-8. 2012
    Real-time PCR shows the widespread presence of Coxiella burnetii DNA in a broad range of commercially available milk and milk products. MLVA genotyping shows that this is the result of the presence of a predominant C...
  80. ncbi Genotypic diversity of clinical Coxiella burnetii isolates from Portugal based on MST and MLVA typing
    Ana Sofia Santos
    Centre for Vectors and Infectious Diseases Research Doutor Francisco Cambournac, National Institute of Health Dr Ricardo Jorge CEVDI INSA, Aguas de Moura, Portugal
    Int J Med Microbiol 302:253-6. 2012
    The temporal and spatial diversity of Coxiella burnetii genotypes associated with human and animal disease in Portugal was analysed using a 6-locus multiple-locus variable-number tandem repeat analysis (MLVA) and a 10-locus multi-spacer ..
  81. pmc Prevalence of Coxiella burnetii antibodies in Danish dairy herds
    Jens F Agger
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 8, Frederiksberg, DK 1870 C, Denmark
    Acta Vet Scand 52:5. 2010
    During recent years in Denmark higher rates of antibodies to Coxiella burnetii have been detected in animals and humans than previously reported...
  82. ncbi Acute hepatitis with or without jaundice: a predominant presentation of acute Q fever in southern Taiwan
    Ko Chang
    Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University, University Hospital, 138 Sheng Li Road, Tainan, Taiwan 704, ROC
    J Microbiol Immunol Infect 37:103-8. 2004
    ..hepatitis and thrombocytopenia, and the latter was likely related to the infection of bone marrow by Coxiella burnetii, as evidenced by the presence of C. burnetii DNA detected by nested polymerase chain reaction...
  83. ncbi Establishment of a genotyping scheme for Coxiella burnetii
    Sanela Svraka
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Microbiol Lett 254:268-74. 2006
    b>Coxiella burnetii is the causative agent of Q fever. The bacterium is highly infectious and is classified as a category B biological weapon...
  84. pmc Highly sensitive real-time PCR for specific detection and quantification of Coxiella burnetii
    Silke R Klee
    Robert Koch Institut, Centre for Biological Safety, Nordufer 20, 13353 Berlin, Germany
    BMC Microbiol 6:2. 2006
    b>Coxiella burnetii, the bacterium causing Q fever, is an obligate intracellular biosafety level 3 agent. Detection and quantification of these bacteria with conventional methods is time consuming and dangerous...
  85. ncbi Experimental Coxiella burnetii infection in pregnant goats: a histopathological and immunohistochemical study
    J Sanchez
    Departamento de Anatomia y Anatomia Patologica Comparadas, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    J Comp Pathol 135:108-15. 2006
    Pregnant goats were inoculated subcutaneosly with Coxiella burnetii and the course of infection was studied. Abortion in the last third of pregnancy occurred in all infected animals...
  86. ncbi Analysis of whole cell lysate from the intercellular bacterium Coxiella burnetii using two gel-based protein separation techniques
    Georgios Samoilis
    Division of Biochemistry, Department of Chemistry, University of Crete, P O Box 2208, GR 71003 Voutes, Greece
    J Proteome Res 6:3032-41. 2007
    b>Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular gamma-proteobacterium, which replicates within large phagolysosome-like compartments formed in the host cell. The global protein profile of intracellular C...
  87. ncbi Outbreak of Q fever associated with a horse-boarding ranch, Colorado, 2005
    Wendy M Bamberg
    Epidemic Intelligence Service, Colorado Department of Public Health and Environment, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Vector Borne Zoonotic Dis 7:394-402. 2007
    b>Coxiella burnetii is a bacterium located worldwide that can cause Q fever when inhaled. We describe an outbreak of Q fever associated with a horse-boarding ranch that had acquired two herds of goats...
  88. pmc Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation
    Dario S Zamboni
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023 062, Brazil
    Infect Immun 72:2395-9. 2004
    Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice...
  89. pmc Functional similarities between the icm/dot pathogenesis systems of Coxiella burnetii and Legionella pneumophila
    Tal Zusman
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Infect Immun 71:3714-23. 2003
    b>Coxiella burnetii, the etiological agent of Q fever, is an obligate intracellular pathogen, whereas Legionella pneumophila, the causative agent of Legionnaires' disease, is a facultative intracellular pathogen...
  90. ncbi Q fever seroprevalence and associated risk factors among students from the Veterinary School of Zaragoza, Spain
    M C Valencia
    Depto de Patologia Animal Enfermedades Infecciosas y Epidemiologia, Universidad de Zaragoza, Spain
    Eur J Epidemiol 16:469-76. 2000
    Q fever is a zoonosis related to the existence of Coxiella burnetii infected animals. The authors studied the seroprevalence and risk factors associated to C. burnetii infection in veterinary students in Zaragoza (Spain)...
  91. ncbi Suburban transmission of Q fever in French Guiana: evidence of a wild reservoir
    J Gardon
    Laboratoire d Epidémiologie, Institut Pasteur de la Guyane, 97306 Cayenne Cedex, France
    J Infect Dis 184:278-84. 2001
    ..Transmission from livestock and dissemination of the bacteria by the wind appeared to be unlikely, which strengthens the hypothesis that a wild reservoir is responsible for transmission...
  92. ncbi Emerging evidence for Q fever in humans in Denmark: role of contact with dairy cattle
    E Bosnjak
    Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Clin Microbiol Infect 16:1285-8. 2010
    ..Preliminary reports now describe Coxiella burnetii in milk samples from Danish dairy cattle...
  93. ncbi Q fever and pregnancy: disease, prevention, and strain specificity
    E Angelakis
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, CNRS UMR 7278, IRD 198, Aix Marseille Universite, 27 Bd Jean Moulin, 13005 Marseille, France
    Eur J Clin Microbiol Infect Dis 32:361-8. 2013
    The link between fetal morbidity and Q fever and the necessity of long-term antibiotics for Coxiella burnetii infection during pregnancy have been recently questioned in the Netherlands, where the clone responsible for the Q fever ..
  94. ncbi Intracellular life of Coxiella burnetii in macrophages
    Eric Ghigo
    URMITE CNRS UMR 6236 IRD 3R198, Institut Federatif de Recherche 48, Universite de la Mediterranee, Marseille, France
    Ann N Y Acad Sci 1166:55-66. 2009
    b>Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C...
  95. ncbi Q fever: the neglected biothreat agent
    P C F Oyston
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 60:9-21. 2011
    b>Coxiella burnetii is the causative agent of Q fever, a disease with a spectrum of presentations from the mild to fatal, including chronic sequelae...
  96. pmc Physical and genetic map of the obligate intracellular bacterium Coxiella burnetii
    H Willems
    Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    J Bacteriol 180:3816-22. 1998
    ..techniques have been used to construct a NotI macrorestriction map of the obligate intracellular bacterium Coxiella burnetii Nine Mile...
  97. ncbi Prevalence of Coxiella burnetii infection in Dutch dairy herds based on testing bulk tank milk and individual samples by PCR and ELISA
    J Muskens
    Animal Health Service, 7400 AA Deventer, The Netherlands
    Vet Rec 168:79. 2011
    ..using an ELISA and a real-time PCR assay based on the detection of the repetitive transposon-like gene of Coxiella burnetii revealed that infection with the bacterium was widespread among Dutch dairy herds, with antibodies detected ..
  98. ncbi Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in The Netherlands
    Boris M Hogema
    Department of Blood borne Infections, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
    Transfusion 52:144-50. 2012
    ..To assess the extent of infection and the safety of donated blood, we tested local blood donations for presence of Coxiella burnetii antibodies and DNA.
  99. ncbi Serological evidence of Coxiella burnetii infection in dogs in a regional centre
    A Cooper
    School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland, Australia
    Aust Vet J 89:385-7. 2011
    OBJECTIVE Investigate the seroprevalence of the causative agent of Q fever, Coxiella burnetii in domestic dogs in the Townsville region, North Queensland, Australia...
  100. pmc Has Coxiella burnetii (Q fever) been introduced into New Zealand?
    Erik Greenslade
    Emerg Infect Dis 9:138-40. 2003
  101. ncbi Q fever: still more queries than answers
    Corine E Delsing
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Adv Exp Med Biol 719:133-43. 2011
    ..Doxycycline is the treatment of choice for acute infection. An alternative for young children and pregnant women is cotrimoxazole. Chronic infection requires long term treatment usually with doxycycline combined with hydroxychloroquine...

Research Grants43

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..for 12 NIAID priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, Toxoplasma gondii, M...
  2. Role of Coxiella burnetii group I introns in growth modulation
    Michael F Minnick; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Coxiella burnetii is an extremely infectious, obligate intracellular bacterium that causes Q fever, and is classified as a Select B Agent...
  3. Multiplex Serodiagnostic Protein Microarray
    PHILIP LOUIS FELGNER; Fiscal Year: 2012
    ..Here we will fabricate whole proteome microarrays for Coxiella burnetii, Rickettsia prowazekii, Brucella melitensis, Salmonella typhi, and non-homologous proteins from related ..
  4. Defining the functions of uncharacterized genes in priority pathogens
    Sean Crosson; Fiscal Year: 2013
    ..genes in NIAID Category A (Bacillus anthracis and Yersinia pestis) and Category B (Brucella abortus and Coxiella burnetii) priority pathogens...
  5. Development of Site-Specific Mutagenesis in Coxiella burnetti
    JAMES EVANS SAMUEL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Coxiella burnetii, a Gram-negative obligate intracellular bacterium, is the etiological agent of acute and chronic Q (query) fever in humans. Analysis of C...
  6. Small Regulatory RNAs of Coxiella burnetii - The Agent of Q Fever
    JAMES MICHAEL BATTISTI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii is an extremely infectious, intracellular bacterium that causes Q fever in humans and is classified as a select agent...
  7. The Role of Antibody-Mediated Protective Immunity Against Q fever
    Guoquan Zhang; Fiscal Year: 2010
    b>Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes the worldwide zoonotic disease, Q fever...
  8. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward I Shaw; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Coxiella burnetii is an obligate intracellular bacterial pathogen that is typically acquired through aerosol exposure...
  9. Functional Characterization of Coxiella burnetii Dot/Icm Substrates
    Daniel E Voth; Fiscal Year: 2010
    b>Coxiella burnetii is an obligate intracellular bacterial pathogen and the etiologic agent of human Q fever. Q fever typically presents as an acute debilitating flu-like illness but can progress to severe, chronic endocarditis...
  10. Innate Immune Response to Coxiella burnetii Infection
    MATTHEW D CALVERLEY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Coxiella burnetii, an NIAID category B priority pathogen and select agent, is the causative agent of the zoonotic disease Q fever...
  11. Characterizing the role of type IV-secreted CpeD and CpeE in Coxiella burnetii in
    Daniel E Voth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii is an intracellular bacterial pathogen and the etiologic agent of human Q fever, an acute debilitating flu-like illness that can progress to chronic endocarditis...
  12. A Systems Biology Approach for Investigating Coxiella burneti Infection
    JUSTIN ANDREW MCDONOUGH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Coxiella burnetii is a Gram-negative, obligate intracellular bacterium that is the causative agent of Q-fever in humans and is further classified as a Class B select agent...
  13. Role of Dsb proteins in F. tularensis virulence
    Barbara J Mann; Fiscal Year: 2010
    ..Com1 is an outer membrane-associated lipoprotein of Coxiella burnetii. Com1-like proteins are present in a number of gram-negative pathogens but their role as virulence factors ..
  14. Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling
    Daniel E Voth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii is the intracellular bacterial agent of human Q fever, a debilitating flu-like illness that can also present as severe chronic endocarditis. C...
  15. Development of O Antigen-based Vaccines Against Q Fever
    Guoquan Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans...
  16. Identification and Role of Type IV Effector Proteins in Coxiella burnetii
    JAMES EVANS SAMUEL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Coxiella burnetii actively express effectors that likely remodel the host cell for replication and are essential for pathogenesis are likely type 4 secretion system-dependent (T4SS), similar to Dot/..
  17. Role of Toll-like receptors in Coxiella burnetii infection
    Mark A Jutila; Fiscal Year: 2013
    ..burnetii infection in the lung. Aim 3: Compare C. burnetii infection response in human TLR4/MD2 transgenic and mouse TLR4 competent mice. ..
  18. Identification and Role of Type IV Effector Proteins in Coxiella burnetii
    JAMES EVANS SAMUEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii actively express effectors that likely remodel the host cell for replication and are essential for pathogenesis are likely type 4 secretion system-dependent (T4SS), similar to Dot/..
  19. Novel Antimicrobials Targeting Bacterial Type IV Secretion Systems
    James E Kirby; Fiscal Year: 2013
    ..pneumophila, Coxiella burnetii and a series of more distantly related T4SS-dependent pathogens...
  20. An Inhalation Model of Q Fever in Guinea Pigs
    Kasi Russell; Fiscal Year: 2005
    Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Due to the highly infectious nature of C...
  21. Pathogenic Roles of Coxiella burnetti Proteins
    James Samuel; Fiscal Year: 2007
    b>Coxiella burnetii, the etiologic agent of Q fever, is an obligate intraceilular bacteria that replicates within an apparently unmodified phagolysosome...
  22. Multiplexed POC Diagnostic System for Bio-Threat Agents
    GEORGE SIGAL; Fiscal Year: 2005
    ..the following ten threat agents: Bacillus anthracis (BA), Yersinia pestis (YP), Francisella tularensis (FT), Coxiella burnetii (Q Fever), Brucellosis ssp, vaccinia virus, Venezuelan Equine Encephalitis (VEE), botulinum toxin A, ricin, ..
  23. VIRULENCE IN COXIELLA BURNETTII
    HERBERT THOMPSON; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Coxiella burnetii infects domestic and wild animals and is distributed worldwide. Human disease, referred to as Q-fever, occurs by contact with infected animals or animal products...
  24. SURFACE CHANGE AND VIRULENCE IN COXIELLA BURNETII
    Michael Kahn; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Coxiella burnetii is an obligate intracellular bacterium which causes both acute Q fever and chronic endocarditis in humans. While information has accumulated concerning aspects of C...
  25. PATHOGENIC ROLES OF COXIELLA BURNETTI SURFACE PROTEINS
    James Samuel; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Coxiella burnetii, the etiologic agent of Q fever, is an obligate intracellular bacterium that replicates within an apparently unmodified phagolysosome...
  26. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..tuberculosis, Brucella abortus, Bartonella species, influenza virus, Borrelia burgdorferi, rotavirus, Coxiella burnetii, and hepatitis virus...
  27. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    b>Coxiella burnetii is an obligate intracellular pathogen that grows within a specialized vacuole that is derived from fusion with lysosomes...
  28. VACCINE INTERVENTION AGAINST Q FEVER
    James Samuel; Fiscal Year: 2003
    ..b>Coxiella burnetii fulfills all these criteria yet public health response to this agent, including vaccine intervention, is ..
  29. Identification of T Cell Antigen For Q Fever Vaccination
    James Samuel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Coxiella burnetii, the etiological agent of "Q-fever", is a category-B bioterrorism agent that is highly infective to both humans and livestock...
  30. American Society for Rickettsiology Conference 2009
    ROMAN GANTA; Fiscal Year: 2009
    ..rickettsiae and rickettsial diseases as well as the more distantly related, but important pathogens, such as Coxiella burnetii (the Q fever agent) and Bartonella species...
  31. PATHOGENIC ROLES OF COXIELLA BURNETII SURFACE PROTEINS
    James Samuel; Fiscal Year: 1999
    The obligate intracellular pathogen, Coxiella burnetii, causes acute and chronic disease in humans...
  32. WHOLE GENOME SEQUENCING OF COXIELLA BURNETTI
    John Heidelberg; Fiscal Year: 2000
    The zoonotic disease Q fever is a caused by the obligate intracellular bacterium Coxiella burnetii. Coxiella burnetii has evolved strategies to survive in the hostile phagolysosomal environment...
  33. Characterization of the Coxiella Dot/lcm homologues
    JOSEPH VOGEL; Fiscal Year: 2006
    b>Coxiella burnetii is a Gram negative bacterium that causes the zoonotic illness Q fever (for query fever)...
  34. Characterizing Coxiella burnetii translocated proteins
    Kimberly Carey; Fiscal Year: 2008
    b>Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular bacterium capable of replicating within acidic phagolysosomes of host cells...
  35. Bartonella Inhibitory Factor for Endothelial Cell Growth
    MICHAEL MINNICK; Fiscal Year: 2002
    ..abstract_text> ..
  36. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..abstract_text> ..
  37. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  38. Murine Typhus: Vector Biology & Transmission
    Abdu Azad; Fiscal Year: 2007
    ..typhi and ELB upon challenge with[unreadable] the heterologous rickettsiae and involvement of 120 kDa in the protection.[unreadable] [unreadable]..
  39. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
  40. Evasion of Macrophage Lysosomes by L pneumophilia
    MICHELE SWANSON; Fiscal Year: 2007
    ..abstract_text> ..
  41. ACTIN BASED MOTILITY BY RICKETTSIA RICKETTSII
    ROBERT HEINZEN; Fiscal Year: 2002
    ..Not only will these studies lead to a greater understanding of molecular mechanisms of rickettsial pathogenesis, but they will also provide insight into the dynamic control of actin polymerization. ..
  42. Analysis of L. Pneumophilia Virulence Regulation
    MICHELE SOMES SWANSON; Fiscal Year: 2010
    ..Thus, concepts and pathways identified here can also guide studies and management of less tractable intracellular pathogens such as the Mycobacteria, Chlamydia, Francisella, and Coxiella species. ..