burkholderia

Summary

Summary: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.

Top Publications

  1. ncbi Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin
    Emilie Lameignere
    CERMAV CNRS affiliated with Université Joseph Fourier and belonging to ICMG, BP 53, F 38041, Grenoble, Cedex 09, France
    Glycobiology 20:87-98. 2010
  2. pmc Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
    Sandra Schwarz
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 6:e1001068. 2010
  3. pmc The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 191:261-77. 2009
  4. pmc Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 11:51. 2011
  5. ncbi Diversity and occurrence of Burkholderia spp. in the natural environment
    Stéphane Compant
    Unité de Recherche Vignes et Vins de Champagne, UFR Sciences, Universite de Reims Champagne Ardenne, Reims, France
    FEMS Microbiol Rev 32:607-26. 2008
  6. ncbi Diversity and significance of Burkholderia species occupying diverse ecological niches
    Tom Coenye
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Environ Microbiol 5:719-29. 2003
  7. pmc Symbiont-mediated insecticide resistance
    Yoshitomo Kikuchi
    Bioproduction Research Institute, Hokkaido Center, National Institute of Advanced Industrial Science and Technology, Sapporo 062 8517, Japan
    Proc Natl Acad Sci U S A 109:8618-22. 2012
  8. ncbi Common features of environmental and potentially beneficial plant-associated Burkholderia
    Zulma Rocío Suárez-Moreno
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Microb Ecol 63:249-66. 2012
  9. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007
  10. ncbi Endophytic colonization of Vitis vinifera L. by Burkholderia phytofirmans strain PsJN: from the rhizosphere to inflorescence tissues
    Stéphane Compant
    Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vignes et Vins de Champagne, UFR Sciences, Universite de Reims Champagne Ardenne, Reims Cedex 2, France
    FEMS Microbiol Ecol 63:84-93. 2008

Detail Information

Publications284 found, 100 shown here

  1. ncbi Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin
    Emilie Lameignere
    CERMAV CNRS affiliated with Université Joseph Fourier and belonging to ICMG, BP 53, F 38041, Grenoble, Cedex 09, France
    Glycobiology 20:87-98. 2010
    The opportunistic pathogen Burkholderia cenocepacia contains three soluble carbohydrate-binding proteins, related to the fucose-binding lectin PA-IIL from Pseudomonas aeruginosa...
  2. pmc Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
    Sandra Schwarz
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 6:e1001068. 2010
    ..In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia thailandensis (B. thai) in eukaryotic and bacterial cell interactions...
  3. pmc The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 191:261-77. 2009
    ..b>Burkholderia cenocepacia infection is particularly problematic since this organism has high levels of antibiotic resistance, ..
  4. pmc Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia
    Kok Gan Chan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Microbiol 11:51. 2011
    ..Here we sought to discover novel N-acylhomoserine lactone (AHL)-dependent QS and QQ strains by investigating a bacterial community associated with the rhizosphere of ginger (Zingiber officinale) growing in the Malaysian rainforest...
  5. ncbi Diversity and occurrence of Burkholderia spp. in the natural environment
    Stéphane Compant
    Unité de Recherche Vignes et Vins de Champagne, UFR Sciences, Universite de Reims Champagne Ardenne, Reims, France
    FEMS Microbiol Rev 32:607-26. 2008
    ..Probably the most diverse and environmentally adaptable plant-associated bacteria belong to the genus Burkholderia. This genus is well-known for its human, animal and plant pathogenic members, including the Burkholderia ..
  6. ncbi Diversity and significance of Burkholderia species occupying diverse ecological niches
    Tom Coenye
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Environ Microbiol 5:719-29. 2003
    Members of the genus Burkholderia are versatile organisms that occupy a surprisingly wide range of ecological niches...
  7. pmc Symbiont-mediated insecticide resistance
    Yoshitomo Kikuchi
    Bioproduction Research Institute, Hokkaido Center, National Institute of Advanced Industrial Science and Technology, Sapporo 062 8517, Japan
    Proc Natl Acad Sci U S A 109:8618-22. 2012
    ..The bean bug Riptortus pedestris and allied stinkbugs harbor mutualistic gut symbiotic bacteria of the genus Burkholderia, which are acquired by nymphal insects from environmental soil every generation...
  8. ncbi Common features of environmental and potentially beneficial plant-associated Burkholderia
    Zulma Rocío Suárez-Moreno
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Microb Ecol 63:249-66. 2012
    The genus Burkholderia comprises more than 60 species isolated from a wide range of niches...
  9. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007
    ..at a posterior midgut region, which house a dense population of a bacterial symbiont belonging to the genus Burkholderia. Although the symbiont is highly prevalent (95 to 100%) in the host populations, the symbiont phylogeny did not ..
  10. ncbi Endophytic colonization of Vitis vinifera L. by Burkholderia phytofirmans strain PsJN: from the rhizosphere to inflorescence tissues
    Stéphane Compant
    Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vignes et Vins de Champagne, UFR Sciences, Universite de Reims Champagne Ardenne, Reims Cedex 2, France
    FEMS Microbiol Ecol 63:84-93. 2008
    The colonization pattern of Vitis vinifera L. by Burkholderia phytofirmans strain PsJN was determined using grapevine fruiting cuttings with emphasis on putative inflorescence colonization under nonsterile conditions...
  11. pmc Involvement of a quorum-sensing-regulated lipase secreted by a clinical isolate of Burkholderia glumae in severe disease symptoms in rice
    Giulia Devescovi
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    Appl Environ Microbiol 73:4950-8. 2007
    b>Burkholderia glumae is an emerging rice pathogen in several areas around the world...
  12. pmc Genetic tools for allelic replacement in Burkholderia species
    Ashley R Barrett
    Department of Microbiology, College of Natural Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Appl Environ Microbiol 74:4498-508. 2008
    Allelic replacement in the Burkholderia genus has been problematic due to the lack of appropriate counter-selectable and selectable markers...
  13. ncbi Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis
    Sarah A Ngugi
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 28:7551-5. 2010
    b>Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B...
  14. pmc Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis
    Matthew E Wand
    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, Devon, EX4 4QD, UK
    BMC Microbiol 11:11. 2011
    b>Burkholderia pseudomallei is the causative agent of melioidosis, a tropical disease of humans with a variable and often fatal outcome. In murine models of infection, different strains exhibit varying degrees of virulence...
  15. pmc Endophytic colonization of Vitis vinifera L. by plant growth-promoting bacterium Burkholderia sp. strain PsJN
    Stéphane Compant
    Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vignes et Vins de Champagne, UPRES EA 2069, UFR Sciences, Universite de Reims Champagne Ardenne, Reims, France
    Appl Environ Microbiol 71:1685-93. 2005
    Patterns of colonization of Vitis vinifera L. cv. Chardonnay plantlets by a plant growth-promoting bacterium, Burkholderia sp. strain PsJN, were studied under gnotobiotic conditions...
  16. pmc Nonviable Burkholderia mallei induces a mixed Th1- and Th2-like cytokine response in BALB/c mice
    Kei Amemiya
    Pathogenesis and Immunology Branch, Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    Infect Immun 70:2319-25. 2002
    Nonviable cell preparations of Burkholderia mallei, the causative agent of glanders, were evaluated as potential vaccine candidates in a BALB/c murine model. Three different B...
  17. pmc The tomato rhizosphere, an environment rich in nitrogen-fixing Burkholderia species with capabilities of interest for agriculture and bioremediation
    Jesus Caballero-Mellado
    Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Ap Postal 565 A, Cuernavaca, Morelos, Mexico
    Appl Environ Microbiol 73:5308-19. 2007
    b>Burkholderia strains are promising candidates for biotechnological applications...
  18. ncbi Burkholderia species are ancient symbionts of legumes
    Cyril Bontemps
    Department of Biology, University of York, PO Box 373, York YO10 5YW, England, UK
    Mol Ecol 19:44-52. 2010
    b>Burkholderia has only recently been recognized as a potential nitrogen-fixing symbiont of legumes, but we find that the origins of symbiosis in Burkholderia are much deeper than previously suspected...
  19. pmc Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
    b>Burkholderia thailandensis is a non-pathogenic environmental saprophyte closely related to Burkholderia pseudomallei, the causative agent of the often fatal animal and human disease melioidosis. To study B...
  20. ncbi Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta
    Geoffrey N Elliott
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    New Phytol 173:168-80. 2007
    The ability of Burkholderia phymatum STM815 to effectively nodulate Mimosa spp., and to fix nitrogen ex planta, was compared with that of the known Mimosa symbiont Cupriavidus taiwanensis LMG19424...
  21. ncbi Burkholderia sabiae sp. nov., isolated from root nodules of Mimosa caesalpiniifolia
    Wen Ming Chen
    Laboratory of Microbiology, Department of Seafood Science, National Kaohsiung Marine University, 142 Hai Chuan Rd, Nan Tzu, Kaohsiung City 811, Taiwan
    Int J Syst Evol Microbiol 58:2174-9. 2008
    ..On the basis of 16S rRNA gene sequence similarities, both strains were shown previously to belong to the genus Burkholderia. A polyphasic approach, including DNA-DNA hybridizations, pulsed-field gel electrophoresis of whole-genome DNA ..
  22. ncbi Development and evaluation of polymerase chain reaction assay to detect Burkholderia genus and to differentiate the species in clinical specimens
    Jeyanthi Suppiah
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    FEMS Microbiol Lett 306:9-14. 2010
    ..Molecular-based techniques are becoming desirable as tools for identification of infectious diseases. Amongst the Burkholderia spp...
  23. pmc Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei
    Andrea Haraga
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Infect Immun 76:5402-11. 2008
    b>Burkholderia pseudomallei is a bacterial pathogen that causes a broad spectrum of clinical symptoms collectively known as melioidosis...
  24. ncbi Burkholderia phytofirmans PsJN acclimates grapevine to cold by modulating carbohydrate metabolism
    Olivier Fernandez
    Universite de Reims Champagne Ardenne, Unité de Recherche Vignes et Vins de Champagne Stress et Environnement EA 2069, UFR Sciences Exactes et Naturelles, BP 1039, 51687 Reims Cedex 2, France
    Mol Plant Microbe Interact 25:496-504. 2012
    ..We have previously demonstrated that Burkholderia phytofirmans PsJN, a plant growth-promoting rhizobacteria (PGPR) that colonizes grapevine, is able to reduce ..
  25. ncbi Expanded range of Burkholderia species in Australia
    Avram Levy
    Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine, Perth, Australia
    Am J Trop Med Hyg 78:599-604. 2008
    This study describes the isolation and characterization of several Burkholderia species from soil in northern Australia...
  26. ncbi Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N
    Kamilia A Tawfik
    Department of Pharmacognosy, Suez Canal University, Ismailia, Egypt 41522
    Org Lett 12:664-6. 2010
    Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N...
  27. ncbi Antibiosis of Burkholderia ubonensis againist Burkholderia pseudomallei, the causative agent for melioidosis
    Kristy Marshall
    Environmental and Public Health Microbiology Research Group, Microbiology and Immunology, James Cook University, Townsville, QLD, Australia
    Southeast Asian J Trop Med Public Health 41:904-12. 2010
    Melioidosis, caused by Burkholderia pseudomallei, is an enigmatic infectious disease that afflicts individuals in many tropical and developing regions...
  28. ncbi Genetic diversity of Mimosa pudica rhizobial symbionts in soils of French Guiana: investigating the origin and diversity of Burkholderia phymatum and other beta-rhizobia
    Ravi P N Mishra
    IRD, UMR LSTM, Montpellier, France
    FEMS Microbiol Ecol 79:487-503. 2012
    ..Interestingly, we found a large diversity of beta-rhizobia, with Burkholderia phymatum and Burkholderia tuberum being the most frequent and diverse symbiotic species...
  29. ncbi Reductive dehalogenation mediated initiation of aerobic degradation of 2-chloro-4-nitrophenol (2C4NP) by Burkholderia sp. strain SJ98
    Janmejay Pandey
    Institute of Microbial Technology CSIR, Sector 39 A, Chandigarh, 160036, India
    Appl Microbiol Biotechnol 92:597-607. 2011
    b>Burkholderia sp. strain SJ98 (DSM 23195) was previously isolated and characterized for degradation and co-metabolic transformation of a number nitroaromatic compounds...
  30. pmc Metabolism of 2-chloro-4-nitrophenol in a gram negative bacterium, Burkholderia sp. RKJ 800
    Pankaj Kumar Arora
    Environmental Biotechnology, Institute of Microbial Technology CSIR, Chandigarh, India
    PLoS ONE 7:e38676. 2012
    ..On the basis of the 16S rRNA gene sequencing, strain RKJ 800 was identified as a member of genus Burkholderia. Our studies clearly showed that Burkholderia sp...
  31. ncbi Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus
    Kirstin Scherlach
    Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Am Chem Soc 128:11529-36. 2006
    ..Here we report the successful isolation and large-scale fermentation of the bacterial endosymbiont ("Burkholderia rhizoxina") in pure culture, which resulted in a significantly elevated (10x higher) production of ..
  32. pmc Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements
    Catherine M Ronning
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 10:202. 2010
    b>Burkholderia species exhibit enormous phenotypic diversity, ranging from the nonpathogenic, soil- and water-inhabiting Burkholderia thailandensis to the virulent, host-adapted mammalian pathogen B. mallei...
  33. pmc Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis
    Vidhya Novem
    Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore
    Clin Vaccine Immunol 16:1420-8. 2009
    b>Burkholderia pseudomallei, the etiological agent of melioidosis, is a facultative intracellular pathogen. As B...
  34. ncbi Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs
    Pamela A Sokol
    University of Calgary, Department of Microbiology and Infectious Diseases, Faculty of Medicine, 3330 Hospital Dr, NW Calgary, Alberta T2N 4N1, Canada
    Future Microbiol 2:555-63. 2007
    The genus Burkholderia not only contains the primary pathogens Burkholderia pseudomallei and Burkholderia mallei but also several species that have emerged as opportunistic pathogens in persons suffering from cystic fibrosis or chronic ..
  35. ncbi Identification of putative noncoding RNA genes in the Burkholderia cenocepacia J2315 genome
    Tom Coenye
    Laboratorium voor Microbiologie, Universiteit Gent, Gent, Belgium
    FEMS Microbiol Lett 276:83-92. 2007
    ..In the present study, the presence of ncRNA genes in the genome of Burkholderia cenocepacia J2315 was evaluated by combining comparative genomics (alignment-based) and predicted secondary ..
  36. pmc A Burkholderia cenocepacia orphan LuxR homolog is involved in quorum-sensing regulation
    Rebecca J Malott
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Bacteriol 191:2447-60. 2009
    b>Burkholderia cenocepacia utilizes quorum sensing to control gene expression, including the expression of genes involved in virulence...
  37. pmc PBAD-based shuttle vectors for functional analysis of toxic and highly regulated genes in Pseudomonas and Burkholderia spp. and other bacteria
    Dongru Qiu
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine at Marshall University, Huntington, West Virginia 25755 9320, USA
    Appl Environ Microbiol 74:7422-6. 2008
    ....
  38. ncbi Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae
    Jinwoo Kim
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Mol Microbiol 64:165-79. 2007
    The bacterium Burkholderia glumae causes rice grain rot by producing toxoflavin, whose expression is regulated by quorum sensing (QS)...
  39. ncbi Burkholderia phytofirmans sp. nov., a novel plant-associated bacterium with plant-beneficial properties
    A Sessitsch
    ARC Seibersdorf Research GmbH, Department of Bioresources Microbiology, Austria
    Int J Syst Evol Microbiol 55:1187-92. 2005
    ..gene sequence data, strain PsJN(T) and the Dutch strains were identified as representing a member of the genus Burkholderia, as they were closely related to Burkholderia fungorum (98.7 %) and Burkholderia phenazinium (98.5 %)...
  40. ncbi Nodulation of legumes by members of the beta-subclass of Proteobacteria
    L Moulin
    Laboratoire des Symbioses Tropicales et Méditerranéennes, IRD INRA CIRAD ENSAM Baillarguet, Montpellier, France
    Nature 411:948-50. 2001
    ..Here we report the identification of proteobacteria from the beta-subclass that nodulate legumes. This finding shows that the ability to establish a symbiosis with legumes is more widespread in bacteria than anticipated to date...
  41. pmc Burkholderia thailandensis oacA mutants facilitate the expression of Burkholderia mallei-like O polysaccharides
    Paul J Brett
    Department of Microbiology and Immunology, University of South Alabama, 5851 USA Drive North, Mobile, AL 36688, USA
    Infect Immun 79:961-9. 2011
    Previous studies have shown that the O polysaccharides (OPS) expressed by Burkholderia mallei are similar to those produced by Burkholderia thailandensis except that they lack the 4-O-acetyl modifications on their 6-deoxy-α-l-..
  42. pmc Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase
    Yinyue Deng
    Institute of Molecular and Cell Biology, Proteos, Singapore
    J Bacteriol 191:7270-8. 2009
    b>Burkholderia cenocepacia produces the molecule cis-2-dodecenoic acid (BDSF), which was previously shown to play a role in antagonism against the fungal pathogen Candida albicans by interfering with its morphological transition...
  43. pmc Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei
    Daniel Godoy
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, London W2 1PG, United Kingdom
    J Clin Microbiol 41:2068-79. 2003
    A collection of 147 isolates of Burkholderia pseudomallei, B. mallei, and B. thailandensis was characterized by multilocus sequence typing (MLST). The 128 isolates of B...
  44. pmc A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo
    Slade A Loutet
    Department of Microbiology and Immunology, Siebens Drake Research Institute, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Bacteriol 188:2073-80. 2006
    b>Burkholderia cenocepacia is an important opportunistic pathogen of patients with cystic fibrosis. This bacterium is inherently resistant to a wide range of antimicrobial agents, including high concentrations of antimicrobial peptides...
  45. ncbi Pathogenic fungus harbours endosymbiotic bacteria for toxin production
    Laila P Partida-Martinez
    Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstr 11a, 07745 Jena, Germany
    Nature 437:884-8. 2005
    ..biosynthesized by the fungus itself, but by endosymbiotic, that is, intracellular living, bacteria of the genus Burkholderia. Our unexpected findings unveil a remarkably complex symbiotic-pathogenic relationship that extends the fungus-..
  46. pmc Pneumonia and septicemia caused by Burkholderia thailandensis in the United States
    Mindy B Glass
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, CDC, MS G34, 1600 Clifton Rd N E, Atlanta, GA 30333, USA
    J Clin Microbiol 44:4601-4. 2006
    b>Burkholderia thailandensis is closely related to Burkholderia pseudomallei, the causative agent of melioidosis. It is generally considered avirulent and previously has been reported to occur only in Southeast Asia...
  47. pmc The Burkholderia Genome Database: facilitating flexible queries and comparative analyses
    Geoffrey L Winsor
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Bioinformatics 24:2803-4. 2008
    ..The Burkholderia Genome Database represents a model for such a database, providing a powerful, user-friendly search and ..
  48. pmc Recovery of a Burkholderia thailandensis-like isolate from an Australian water source
    Jay E Gee
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    BMC Microbiol 8:54. 2008
    b>Burkholderia thailandensis, a close relative of Burkholderia pseudomallei, has previously been reported only from Southeast Asia and North America. It is biochemically differentiated from B...
  49. pmc Development of a recA gene-based identification approach for the entire Burkholderia genus
    George W Payne
    Cardiff School of Biosciences, Main Building, Museum Avenue, PO Box 915, Cardiff University, Cardiff, Wales CF10 3TL, United Kingdom
    Appl Environ Microbiol 71:3917-27. 2005
    b>Burkholderia is an important bacterial genus containing species of ecological, biotechnological, and pathogenic interest...
  50. ncbi Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic Burkholderia ambifaria Genomic Island
    Eshwar Mahenthiralingam
    Organisms and Environment Division, Cardiff School of Biosciences, Cardiff University, Wales, UK
    Chem Biol 18:665-77. 2011
    Gram-negative Burkholderia cepacia complex (Bcc) isolates were screened for antimicrobial activity against cystic fibrosis microbial pathogens, and the ability of B. ambifaria to inhibit B. multivorans was identified...
  51. pmc Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans
    Shi En Lu
    Mississippi State University, Department of Entomology, Mississippi State, Mississippi 39762, USA
    Biochemistry 48:8312-21. 2009
    Bacterial strain Burkholderia contaminans MS14 was isolated from soil that suppressed brown patch disease of lawn grass. An antifungal compound was purified from the liquid culture of this bacterium...
  52. ncbi Burkholderia caribensis sp. nov., an exopolysaccharide-producing bacterium isolated from vertisol microaggregates in Martinique
    W Achouak
    DSV DEVM, Laboratoire d Ecologie Microbienne de la Rhizosphere, UMR 163 CNRS CEA, CEA Cadarache, Saint Paul lez Durance, France
    Int J Syst Bacteriol 49:787-94. 1999
    ..Although these strains were phenotypically identified as Burkholderia cepacia or as Burkholderia glathei using BIOLOG microplates, they did not cluster genotypically by amplified ..
  53. ncbi Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkholderia thailandensis
    Carol Gebhart
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Glycobiology 22:962-74. 2012
    ..The hypothetical proteins BTH_I0650 from Burkholderia thailandensis E264 and VC0393 from Vibrio cholerae N16961 contain the Wzy_C domain...
  54. ncbi Trehalose metabolism is activated upon chilling in grapevine and might participate in Burkholderia phytofirmans induced chilling tolerance
    Olivier Fernandez
    Unité de Recherche Vignes et Vins de Champagne EA 2069, Laboratoire de Stress, Défense et Reproduction des Plantes, UFR Sciences Exactes et Naturelles, Universite de Reims Champagne Ardenne, BP 1039, 51687, Reims Cedex 2, France
    Planta 236:355-69. 2012
    ..in the response of grapevine to chilling stress, and to compare the response in plants bacterised with Burkholderia phytofirmans strain PsJN, a plant growth-promoting rhizobacterium that confers grapevine chilling tolerance, ..
  55. ncbi Beta-rhizobia from Mimosa pigra, a newly discovered invasive plant in Taiwan
    Wen Ming Chen
    Department of Seafood Science, National Kaohsiung Marine University, 142 Hai Chuan Road, Nan Tzu, Kaohsiung City 811, Taiwan
    New Phytol 168:661-75. 2005
    ..Of these, 96% were identified as Burkholderia and 4% as Cupriavidus taiwanensis...
  56. ncbi Biotechnological potential within the genus Burkholderia
    L A O'Sullivan
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Lett Appl Microbiol 41:8-11. 2005
    Many species within the genus Burkholderia possess significant biotechnological potential in bioremediation and biological control...
  57. pmc Specific developmental window for establishment of an insect-microbe gut symbiosis
    Yoshitomo Kikuchi
    Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Hokkaido Center, 2 17 2 1 Tsukisamu Higashi, Toyohira, Sapporo 062 8517, Japan
    Appl Environ Microbiol 77:4075-81. 2011
    The alydid stinkbug Riptortus pedestris is specifically associated with a beneficial Burkholderia symbiont in the midgut crypts...
  58. pmc Enhancement of chilling resistance of inoculated grapevine plantlets with a plant growth-promoting rhizobacterium, Burkholderia phytofirmans strain PsJN
    Essaid Ait Barka
    Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vignes et Vins de Champagne, UPRES EA 2069, UFR Sciences, Universite de Reims Champagne Ardenne, 51687 Reims Cedex 2, France
    Appl Environ Microbiol 72:7246-52. 2006
    In vitro inoculation of Vitis vinifera L. cv. Chardonnay explants with a plant growth-promoting rhizobacterium, Burkholderia phytofirmans strain PsJN, increased grapevine growth and physiological activity at a low temperature...
  59. ncbi p-Nitrophenol degradation via 4-nitrocatechol in Burkholderia sp. SJ98 and cloning of some of the lower pathway genes
    Archana Chauhan
    Institute of Microbial Technology Sector 39A, Chandigarh 160036, India
    Environ Sci Technol 44:3435-41. 2010
    ..In the present study we identified a Gram negative organism viz. Burkholderia sp. strain SJ98 that degrades PNP via 4NC, BT, and MA. A 6...
  60. ncbi Relevance of metal ions for lipase stability: structural rearrangements induced in the Burkholderia glumae lipase by calcium depletion
    Gaetano Invernizzi
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Milano, Italy
    J Struct Biol 168:562-70. 2009
    We have studied the accessibility of the structural calcium ion in the Burkholderia glumae lipase and the consequences of its removal on the protein conformation by different biophysical techniques (circular dichroism, fluorimetry, and ..
  61. pmc The quorum sensing-dependent gene katG of Burkholderia glumae is important for protection from visible light
    Heejin Chun
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    J Bacteriol 191:4152-7. 2009
    Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, the causative agent of bacterial rice grain rot. We determined how QS is involved in catalase expression in B. glumae. The QS-defective mutant of B...
  62. ncbi Proteomic analysis of the proteins regulated by HrpB from the plant pathogenic bacterium Burkholderia glumae
    Yongsung Kang
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Proteomics 8:106-21. 2008
    ..To identify the proteins controlled by HrpB in Burkholderia glumae in vitro, we constitutively expressed hrpB and analyzed the proteins showing altered expression using 2-..
  63. ncbi Burkholderia ferrariae sp. nov., isolated from an iron ore in Brazil
    Angel Valverde
    Instituto de Recursos Naturales y Agrobiologia de Salamanca, Consejo Superior de Investigaciones Cientificas, 37071 Salamanca, Spain
    Int J Syst Evol Microbiol 56:2421-5. 2006
    ..16S rRNA gene sequence analysis indicated that it formed a distinct phylogenetic lineage within the genus Burkholderia together with several other species of the genus, e.g...
  64. ncbi Quorum sensing and indole-3-acetic acid degradation play a role in colonization and plant growth promotion of Arabidopsis thaliana by Burkholderia phytofirmans PsJN
    Ana Zúñiga
    Universidad Adolfo Ibáñez, Santiago, Chile
    Mol Plant Microbe Interact 26:546-53. 2013
    ..b>Burkholderia phytofirmans PsJN is a well-known plant-growth-promoting bacterium, which establishes rhizospheric and ..
  65. pmc Distribution of quorum-sensing genes in the Burkholderia cepacia complex
    E Lutter
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
    Infect Immun 69:4661-6. 2001
    The distribution of quorum-sensing genes among strains from seven genomovars of the Burkholderia cepacia complex was examined by PCR. cepR and cepI were amplified from B. cepacia genomovars I and III, B. stabilis, and B. vietnamiensis...
  66. ncbi Comparative analysis of defence responses induced by the endophytic plant growth-promoting rhizobacterium Burkholderia phytofirmans strain PsJN and the non-host bacterium Pseudomonas syringae pv. pisi in grapevine cell suspensions
    Sophie Bordiec
    Universite de Reims Champagne Ardenne, URVVC SE EA 2069, Laboratoire Stress, Défense et Reproduction des Plantes, BP 1039, F 51687 Reims Cedex 2, France
    J Exp Bot 62:595-603. 2011
    ..b>Burkholderia phytofirmans strain PsJN is an endophytic PGPR that colonizes grapevine and protects the plant against the grey ..
  67. ncbi Burkholderia terrae sp. nov., isolated from a forest soil
    Hee Chan Yang
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1, Guseong Dong, Yuseong Gu, Daejeon, 305 701, South Korea
    Int J Syst Evol Microbiol 56:453-7. 2006
    ..was shown to belong to the family Burkholderiaceae of the Betaproteobacteria, and to be related most closely to Burkholderia hospita LMG 20598T (98.7%), Burkholderia caribensis LMG 18531T (98.0%) and Burkholderia phymatum LMG 21445T (97...
  68. ncbi Toxicity of mono-, di- and tri-chlorophenols to lux marked terrestrial bacteria, Burkholderia species Rasc c2 and Pseudomonas fluorescens
    E M Boyd
    Centre for Ecology and Hydrology, Huntingdon, Cambridgeshire, UK
    Chemosphere 43:157-66. 2001
    b>Burkholderia species RASC and Pseudomonas fluorescens were marked with lux genes, encoding for bioluminescence and used to assess the toxicity of mono-, di- and tri-chlorophenols by determining the decline in bioluminescence following ..
  69. ncbi DNA microarray-based detection and identification of Burkholderia mallei, Burkholderia pseudomallei and Burkholderia spp
    Gernot Schmoock
    Institute of Bacterial Infections and Zoonoses at the Federal Research Institute for Animal Health Friedrich Loeffler Institut, Naumburger Strasse 96a, 07743 Jena, Germany
    Mol Cell Probes 23:178-87. 2009
    ..microarray assay based on genetic markers for the accurate identification and differentiation of Burkholderia (B.) mallei and Burkholderia pseudomallei, the agents of glanders and melioidosis, respectively...
  70. ncbi Epidemiology and molecular characterization of a clone of Burkholderia cenocepacia responsible for nosocomial pulmonary tract infections in a French intensive care unit
    Arnault Graindorge
    Universite de Lyon, Caserne Sergent Blandan, 37 Rue du Repos, 69361 Lyon, France
    Diagn Microbiol Infect Dis 66:29-40. 2010
    ..reaction-restriction fragment length polymorphism analysis and molecular phylogeny positioned the isolates into Burkholderia cenocepacia...
  71. ncbi Burkholderia tuberum sp. nov. and Burkholderia phymatum sp. nov., nodulate the roots of tropical legumes
    Peter Vandamme
    Laboratorium voor Microbiologie, Faculteit Wetenschappen, Universiteit Gent, Gent, Belgium
    Syst Appl Microbiol 25:507-12. 2002
    ..One isolate was identified as Burkholderia cepacia genomovar VI, a B...
  72. pmc Complete genome sequence of the plant growth-promoting endophyte Burkholderia phytofirmans strain PsJN
    Alexandra Weilharter
    AIT Austrian Institute of Technology GmbH, Department of Health and Environment, A 3430 Tulln, Austria
    J Bacteriol 193:3383-4. 2011
    b>Burkholderia phytofirmans PsJN(T) is able to efficiently colonize the rhizosphere, root, and above-ground plant tissues of a wide variety of genetically unrelated plants, such as potatoes, canola, maize, and grapevines...
  73. ncbi Burkholderia symbiotica sp. nov., isolated from root nodules of Mimosa spp. native to north-east Brazil
    Shih Yi Sheu
    Department of Marine Biotechnology, National Kaohsiung Marine University, No 142, Hai Chuan Road Nan Tzu, Kaohsiung City 811, Taiwan, ROC
    Int J Syst Evol Microbiol 62:2272-8. 2012
    ..3 % sequence similarity to the closest related species Burkholderia soli GP25-8(T), 97.3 % sequence similarity to Burkholderia caryophylli ATCC25418(T) and 97...
  74. ncbi High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species
    Dimitry V Viktorov
    Research Institute for Plague Control, Golubinskaya st 7, 400131 Volgograd, Russia
    Trans R Soc Trop Med Hyg 102:S103-10. 2008
    ..mechanisms involved in the development of a high level of resistance to a wide range of antimicrobials in Burkholderia pseudomallei and closely related species have not been sufficiently investigated...
  75. ncbi An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients
    T Mann
    Infectious Diseases Unit, Sheba Medical Center, 52621, Tel Hashomer, Israel
    Infection 38:187-94. 2010
    b>Burkholderia cepacia is a common environmental bacterium that is resistant to disinfectants, and therefore is often encountered as a hospital-acquired pathogen. We describe an outbreak of B...
  76. ncbi A system for the construction of targeted unmarked gene deletions in the genus Burkholderia
    Ronald S Flannagan
    Infectious Diseases Research Group, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Environ Microbiol 10:1652-60. 2008
    b>Burkholderia species are extremely multidrug resistant, environmental bacteria with extraordinary bioremediation and biocontrol properties...
  77. ncbi Burkholderia diazotrophica sp. nov., isolated from root nodules of Mimosa spp
    Shih Yi Sheu
    Department of Marine Biotechnology, National Kaohsiung Marine University, 142 Hai Chuan Road, Nan Tzu, Kaohsiung City 811, Taiwan, ROC
    Int J Syst Evol Microbiol 63:435-41. 2013
    ..2 % sequence similarity to the closest related species Burkholderia acidipaludis SA33(T), a similarity of 97.2 % to Burkholderia terrae KMY02(T), 97...
  78. ncbi Burkholderia cenocepacia strains isolated from cystic fibrosis patients are apparently more invasive and more virulent than rhizosphere strains
    Luisa Pirone
    ENEA C R Casaccia Department of Biotechnologies, Agroindustry and Protection of Health, Plant Genetics and Genomics Section, Rome, Italy
    Environ Microbiol 10:2773-84. 2008
    Given the widespread presence of Burkholderia cenocepacia in the rhizosphere it is important to determine whether rhizosphere strains are pathogenic for cystic fibrosis patients or not. Eighteen B...
  79. ncbi The wbiA locus is required for the 2-O-acetylation of lipopolysaccharides expressed by Burkholderia pseudomallei and Burkholderia thailandensis
    Paul J Brett
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive NW, T2N 4N1, Calgary, AB, Canada
    FEMS Microbiol Lett 218:323-8. 2003
    b>Burkholderia pseudomallei and Burkholderia thailandensis express similar O-antigens (O-PS II) in which their 6-deoxy-alpha-L-talopyranosyl (L-6dTalp) residues are variably substituted with O-acetyl groups at the O-2 or O-4 positions...
  80. ncbi Burkholderia mimosarum sp. nov., isolated from root nodules of Mimosa spp. from Taiwan and South America
    Wen Ming Chen
    Department of Seafood Science, National Kaohsiung Marine University, No 142, Hai Chuan Road, Nan Tzu, Kaohsiung City 811, Taiwan
    Int J Syst Evol Microbiol 56:1847-51. 2006
    ..all of the strains were previously shown to be closely related to each other and to belong to the genus Burkholderia. A polyphasic approach, including DNA-DNA reassociation, whole-cell protein analysis, fatty acid methyl ester ..
  81. ncbi Burkholderia nodosa sp. nov., isolated from root nodules of the woody Brazilian legumes Mimosa bimucronata and Mimosa scabrella
    Wen Ming Chen
    Laboratory of Microbiology, Department of Seafood Science, National Kaohsiung Marine University, 142 Hai Chuan Rd, Nan Tzu, Kaohsiung City 811, Taiwan
    Int J Syst Evol Microbiol 57:1055-9. 2007
    ..the basis of 16S rRNA gene sequence similarities, all the strains were shown previously to belong to the genus Burkholderia. A polyphasic approach, including DNA-DNA hybridizations, PFGE of whole-genome DNA profiles, whole-cell protein ..
  82. ncbi A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens
    Ondrej Sulák
    National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Structure 18:59-72. 2010
    The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C...
  83. ncbi Utilization of homoserine lactone as a sole source of carbon and energy by soil Arthrobacter and Burkholderia species
    Wan Wan Yang
    Environmental Science and Engineering, W M Keck Laboratories, California Institute of Technology, Pasadena, CA 91125, USA
    Arch Microbiol 185:47-54. 2006
    ..that three are distinct members of the genus Arthrobacter, whereas the fourth clusters within the non-clinical Burkholderia. The optimal pH for growth of the isolates ranged from 6.0 to 6...
  84. ncbi Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus
    Laila P Partida-Martinez
    Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena, Germany
    Int J Syst Evol Microbiol 57:2583-90. 2007
    ..gene sequences, which revealed that the novel fungal endosymbionts formed a monophyletic group within the genus Burkholderia. Inter-sequence similarities ranged from 98...
  85. pmc Experimental adaptation of Burkholderia cenocepacia to onion medium reduces host range
    Crystal N Ellis
    Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, 212 Rudman Hall, Durham, NH 03824, USA
    Appl Environ Microbiol 76:2387-96. 2010
    ..We investigated this dynamic using a soil isolate of Burkholderia cenocepacia, a species that normally inhabits the rhizosphere, is related to the onion pathogen B...
  86. pmc Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia
    Steve P Bernier
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, 3330 Hospital Dr N W, Calgary, Alberta, Canada
    J Bacteriol 187:5278-91. 2005
    We have previously shown differences in virulence between species of the Burkholderia cepacia complex using the alfalfa infection model and the rat agar bead chronic infection model...
  87. pmc Expanded multilocus sequence typing for burkholderia species
    Theodore Spilker
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, 48109 0646, USA
    J Clin Microbiol 47:2607-10. 2009
    PCR primers targeting loci in the current Burkholderia cepacia complex multilocus sequence typing scheme were redesigned to (i) more reliably amplify these loci from B...
  88. pmc Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B
    Ximena Ortega
    Infectious Diseases Research Group, Siebens Drake Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 284:21738-51. 2009
    b>Burkholderia cenocepacia is an opportunistic pathogen that displays a remarkably high resistance to antimicrobial peptides...
  89. ncbi Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism
    Laila P Partida-Martinez
    Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany
    Curr Biol 17:773-7. 2007
    ..microsporus represents a unique example of a mutualistic life form in which a fungus harbors endobacteria (Burkholderia sp.) for the production of a phytotoxin...
  90. pmc Sero-characterization of lipopolysaccharide from Burkholderia thailandensis
    Omar Qazi
    Department of Pediatrics and the Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
    Trans R Soc Trop Med Hyg 102:S58-60. 2008
    We report the successful purification of lipopolysaccharide (LPS) from Burkholderia thailandensis, a Gram-negative bacterium, closely related to the highly pathogenic organisms B. pseudomallei and B. mallei...
  91. pmc Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping
    Pavel Drevinek
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Clin Microbiol 48:34-40. 2010
    b>Burkholderia cenocepacia can cause serious infections and epidemics in patients with cystic fibrosis (CF). A CF population in the Czech Republic experienced an epidemic outbreak caused by a B. cenocepacia ST-32 strain...
  92. pmc Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis
    Ashraf S Ibrahim
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Infect Dis 198:1083-90. 2008
    Environmental isolates of the fungus Rhizopus have been shown to harbor a bacterial endosymbiont (Burkholderia) that produces rhixozin, a plant mycotoxin...
  93. pmc Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts
    Laila P Partida-Martinez
    Leibniz Institute for Natural Product Research and Infection Biology HKI, Jena, Germany
    Appl Environ Microbiol 73:793-7. 2007
    ..based on 16S rRNA gene sequences revealed that the fungus is associated with bacteria belonging to the genus Burkholderia. By transmission electron microscopy, the bacteria were localized within the fungal cytosol...
  94. ncbi Lack of evidence of endosymbiotic toxin-producing bacteria in clinical Rhizopus isolates
    Laila P Partida-Martinez
    Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Mycoses 51:266-9. 2008
    ..We recently noted that several strains of Rhizopus microsporus harbour rare bacterial endosymbionts (Burkholderia sp...
  95. ncbi The presence of a 1-aminocyclopropane-1-carboxylate (ACC) deaminase deletion mutation alters the physiology of the endophytic plant growth-promoting bacterium Burkholderia phytofirmans PsJN
    Yili Sun
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    FEMS Microbiol Lett 296:131-6. 2009
    ..1-aminocyclopropane-1-carboxylate (ACC) deaminase (acdS) from the endophytic plant growth-promoting bacterium Burkholderia phytofirmans PsJN was isolated and used to construct a mutant strain B. phytofirmans YS2 (B...
  96. ncbi Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis
    Patompon Wongtrakoongate
    Department of Biology, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand
    Mol Cell Probes 21:81-91. 2007
    b>Burkholderia pseudomallei is a bacterial pathogen causing the melioidosis disease, which is predominantly found in tropical areas of Southeast Asia and Northern Australia. Burkholderia thailandensis is a closely related species to B...
  97. pmc Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis
    Gerald Lackner
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstr 11a, 07745 Jena, Germany
    Appl Environ Microbiol 75:2982-6. 2009
    ..representing highly diverse geographic origins and ecological niches. All endosymbionts belonged to the Burkholderia rhizoxinica complex according to matrix-assisted laser desorption ionization-time of flight biotyping and ..
  98. pmc Use of 16S rRNA gene sequencing for rapid identification and differentiation of Burkholderia pseudomallei and B. mallei
    Jay E Gee
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4647-54. 2003
    b>Burkholderia pseudomallei and B. mallei, the causative agents of melioidosis and glanders, respectively, are designated category B biothreat agents...
  99. ncbi Burkholderia oklahomensis sp. nov., a Burkholderia pseudomallei-like species formerly known as the Oklahoma strain of Pseudomonas pseudomallei
    Mindy B Glass
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, 1600 Clifton Rd, NE, MS D11, Atlanta, GA 30333, USA
    Int J Syst Evol Microbiol 56:2171-6. 2006
    C6786, the clinical isolate of the 'Oklahoma' strain of Pseudomonas (now Burkholderia) pseudomallei, was originally isolated in 1973 from a wound infection resulting from a farming accident in Oklahoma, USA...
  100. pmc Targeted mutagenesis of Burkholderia thailandensis and Burkholderia pseudomallei through natural transformation of PCR fragments
    Metawee Thongdee
    Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Appl Environ Microbiol 74:2985-9. 2008
    b>Burkholderia pseudomallei is the causative agent of melioidosis, an overwhelming, rapidly fatal septic infection, and B. thailandensis is a closely related, less virulent species...
  101. pmc Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Appl Environ Microbiol 70:6173-80. 2004
    ..The Burkholderia thailandensis quorum system is comprised of at least three AHL synthases (AHSs) and five transcriptional ..

Research Grants65

  1. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..discovered serodiagnostic antigens for 12 NIAID priority agents (Brucella melitensis, Francisella tularensis, Burkholderia pseudomallei, Coxiella burnetii, Salmonella enterica typhi, Rickettsia rickettsii, Orientia tsutsugamushi, ..
  2. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..also to provide new products for the therapy of Select Agents, such as Plague, Anthrax and pathogens such as Burkholderia mallei and pseudomallei...
  3. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..Related clinically important Gram-negative [Gr(-)] nonfermenters include species of the genera Burkholderia, Acinetobacter, and Stenotrophomonas, which are prevalent in severe nosocomial infections, such as pneumonia, ..
  4. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..TRIAD has selected Category A pathogens F. tularensis, Category B agents Burkholderia pseudomallei and Burkholderia mallei, and emerging infectious diseases (HCV, H...
  5. Novel gene-silencing therapeutics for multidrug-resistant gram-negative pathogens
    DAVID ELIHU GREENBERG; Fiscal Year: 2013
    ..a variety of bacterial pathogens including the Gram-negative bacteria Escherichia coli, Salmonella typhimurium, Burkholderia cepacia complex and Acinetobacter baumannii...
  6. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium.
  7. Structural and Biochemical Studies of LpxC Inhibition
    Pei Zhou; Fiscal Year: 2012
    ..is ineffective against multidrug-resistant Gram-negative pathogens such as Acinetobacter calcoaceticus and Burkholderia cepacia...
  8. Regulatory Circuits Controlling Development of Dormant Microbial Cysts
    CARL EUGENE BAUER; Fiscal Year: 2013
    ..medicae, Sinorhizobium meliloti, Sinorhizobium fredii, Delftia acidovorans (Comamonas acidovorans), Burkholderia mallei (Pseudomonas mallei))...
  9. Genetic Approaches to Lipid Metabolism
    John E Cronan; Fiscal Year: 2013
    ..Prior work demonstrated how the Burkholderia cenocepacia DSF is synthesized, but that enzyme is not fully understood or conserved in some other DSF- ..
  10. The population genetics of antibiotic resistance in multi-drug environments
    Roy Kishony; Fiscal Year: 2013
    ..towards multi-drug resistance taken by a pathogen in clinical settings, focusing on a small outbreak of Burkholderia dolosa in cystic fibrosis patients, where a single infecting strain has evolved in parallel in multiple ..
  11. The role of Burkholderia in giant cell arteritis
    Curry Koening; Fiscal Year: 2013
    ..We discovered by genetic analysis that a strain of Burkholderia was present in the temporal artery wall of patients with GCA...
  12. Development and Testing of Novel Glanders Vaccine Candidates
    Paul J Brett; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Burkholderia mallei, the etiologic agent of glanders, cause severe disease in humans and animals and are a potential agent of biological warfare and terrorism...
  13. Nanoscale Optical Fiber Biosensor Assays for Detection of Category A and B Select
    Thomas J Inzana; Fiscal Year: 2010
    ..optical fiber biosensors for the diagnosis of the Category A and B select agents Francisella tularensis, Burkholderia mallei, and B...
  14. Contact Dependent Growth Inhibition in Burkholderia pseudomallei
    Peggy A Cotter; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative environmental saprotroph endemic to southeast Asia and northern Australia that causes melioidosis, a serious and often lethal human disease...
  15. Blood Transcriptional Biomarker Profiles for Category B Pathogens
    Damien Chaussabel; Fiscal Year: 2013
    ..In the context of this project: (1) we will collect blood samples from well characterized patients with sepsis (Burkholderia pseudomallei / Khon Kaen University, Thailand), persistent fever (Brucella sp...
  16. Development of a Novel Lead Series Against Category A &B Bacterial Pathogens
    Terry L Bowlin; Fiscal Year: 2013
    ..species, including a number of Category A and B agents such as Yersinia pestis, Francisella tularensis, Burkholderia mallei and pseudomallei...
  17. Inhalable Gallium Nitrate Anti-Infective Powder for CF
    Vu L Truong; Fiscal Year: 2010
    ..aeruginosa, Burkholderia cepacia and methycillin-resistant Staphylococcus aureus (MRSA)...
  18. INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS
    Stephen C Winans; Fiscal Year: 2010
    ..Cepl and CepR of Burkholderia cenocepacia regulate many genes on several chromosomes and plasmid of this bacterium, while Yenl and YenR of ..
  19. Gene silencing therapeutics for chronic infections in cystic fibrosis
    DAVID ELIHU GREENBERG; Fiscal Year: 2013
    ..Examples of inherently drug resistant Gram-negative pathogens are Pseudomonas aeruginosa and the Burkholderia cepacia complex (Bcc)...
  20. CHEMOTACTIC SENSORY TRANSDUCTION IN BACILLUS SUBTILIS
    George W Ordal; Fiscal Year: 2012
    ..subtilis chemotaxis mechanism. Furthermore, many Gram-negative pathogens including Burkholderia sp., Campylobacter jejuni, Helicobacter sp...
  21. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT ..
  22. Non-invasive Optical Imaging of Select Agent Bacteria in Non-human Primates
    Frederick D Quinn; Fiscal Year: 2010
    ..This is particularly true for the candidate bioterrorism agents, Burkholderia. pseudomallei (Bp) and Burkholderia mallei (Bm), the causative agents of human melioidosis and glanders...
  23. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..on strong preliminary data, we believe that many pulmonary microorganisms, including Streptococcus pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that can activate NKT ..
  24. Isolating novel fungi for antibiotic discovery
    Losee Lucy Ling; Fiscal Year: 2012
    ..we are rapidly running out of options for treating multidrug resistant species of Pseudomonas, Acinetobacter, Burkholderia, Klebsiella and Enterobacter...
  25. Analysis of a Burkholderia mallei Virulence-Associated Type VI Secretion System
    Paul J Brett; Fiscal Year: 2011
    PROJECT SUMMARY/ABSTRACT Burkholderia mallei, the etiologic agent of glanders, causes severe disease in humans and animals and is a potential agent of biological warfare and terrorism...
  26. Bacterial gene regulation in response to oxidative stress
    Anne Grove; Fiscal Year: 2013
    ..Using Burkholderia thailandensis as a model system, we plan to identify the mechanism of urate-mediated attenuation of DNA binding ..
  27. IMPDH-targeted antibiotics for select agents
    LIZBETH K HEDSTROM; Fiscal Year: 2013
    ..Gram-negative facultative intracellular), Listeria monocytogenes (Gram- positive facultative intracellular), Burkholderia mallei/pseudomallei (Gram-negative facultative intracellular), Staphylococcus aureus (Gram-positive) and ..
  28. Pulmonary Pathogen-Recognition Pathways in Melioidosis
    TIMOTHY EOIN WEST; Fiscal Year: 2013
    ..is to define pulmonary pathogen-recognition pathways in melioidosis, a lethal tropical infection caused by Burkholderia pseudomallei, a potential aerosol bioweapon. Dr...
  29. Regulation of host inflammatory responses and outcome in melioidosis by TLR5
    TIMOTHY EOIN WEST; Fiscal Year: 2013
    ..an often lethal emerging infectious disease caused by the Gram-negative soil saprophyte and putative bioweapon, Burkholderia pseudomallei. Endemic in northeast Thailand, mortality exceeds 40%...
  30. Inhibitors of Type III Secretion and Translocation in yersinia
    Joan Mecsas; Fiscal Year: 2009
    ..coli, Chylamydia, and Burkholderia, use type III secretion systems (TTSS) to translocate effector proteins from the bacterial cytosol into ..
  31. Toll-like receptor interactions and their contribution to airway inflammation
    Tamene Melkamu; Fiscal Year: 2013
    ..of Alternaria alternata, a fungus detected by TLR2 and known to induce acute asthmatic episodes, alongwith Burkholderia cenocepacia,an opportunistic bacterium that activated TLRS and causes pulmonary infection in individuals with ..
  32. NMR studies of bacterial needle and tip proteins
    Roberto N De Guzman; Fiscal Year: 2012
    ..Over the past two years, we have completed the NMR structures of two needle monomers: BsaL from Burkholderia pseudomallei, a pathogen associated with biowarfare, and PrgI from Salmonella typhimurium, a pathogen ..
  33. World Melioidosis Congress 2010
    Herbert P Schweizer; Fiscal Year: 2010
    ..The last decade saw a surge in melioidosis research largely because the etiologic agent Burkholderia pseudomallei is considered an emerging pathogen in many tropical and subtropical regions of the world and also ..
  34. Interruption of Signaling-Mediated Bacterial Persistent Infections
    Laurence G Rahme; Fiscal Year: 2013
    ..Our findings sho that Pseudomonas aeruginosa and Burkholderia species excrete a small molecule that serves as a persistence "infochemical" that signals the accumulation of ..
  35. Burkholderia: International Collaborative Development of Novel Diagnostics
    PAUL STEPHEN KEIM; Fiscal Year: 2011
    We will develop clinical diagnostics tests for two Category B agents (Burkholderia pseudomallei and B. mallei) based upon real-time PCR low density microarrays and MLVA in order to provide rapid and accurate information to physicians...
  36. Development and Formulation of Broad Spectrum Antimicrobials for Biodefense
    Richard A Slayden; Fiscal Year: 2010
    ..Phase 1 clinical trials for treating the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersinia pestis...
  37. Virulence Determinants for Host Tropism in the Burkholderia cepacia complex
    Joanna B Goldberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Burkholderia cepacia complex (Bcc) is a group of Gram-negative bacteria that are ubiquitous in the environment and have emerged as opportunistic pathogens in immunocompromised patients...
  38. Mechanisms of Enteric Burkholderia psuedomallei infection
    Steven W Dow; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei (Bp) is a Gram-negative bacterial pathogen that can cause a variety of difficult-to-treat infections in humans ranging from acute sepsis to chronic abscesses...
  39. Burkholderia: Characterizing Lung Innate Immunity
    Tonyia D Eaves Pyles; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Burkholderia (B.) mallei is a highly evolved Gram-negative bacterium that primarily infects solipeds but it is transmissible to humans by ingestion, cutaneous or aerosol exposures...
  40. Antigen Detection Assay for the Diagnosis of Melioidosis
    Raymond Houghton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis...
  41. Novel Molecular Recognition Reagents for Detection of Pathogenic Burkholderia
    KATHERINE ANNE BROWN; Fiscal Year: 2010
    ..are to develop an efficient novel assay methodology for the detection of the category B biothreat agents, Burkholderia mallei (the causative agent of glanders) and Burkholderia pseudomallei (the causative agent of melioidosis)...
  42. Chemical biology of bacterial symbionts
    Jon Clardy; Fiscal Year: 2013
    ..Bacteria from several genera - Pseudomonas, Burkholderia, and Flavobacteria among others - are used by some social amoebas (Dictyostelium discoideum) to defend ..
  43. DNA Fragment Capture System to Create Burkholderia pseudomallei isogenic Strains
    BRIAN HOWARD KVITKO; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei is the causative agent of melioidosis and a category B select agent for bioterrorism. Strains of B. pseudomallei display high levels of genomic diversity...
  44. Inter-Bacterial Competition Systems in Burkholderia pseudomallei
    Erin C Garcia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei, the causative agent of melioidosis and a potential bioterrorism threat, is intrinsically resistant to most commonly-prescribed antibiotics, demonstrating a clear requirement ..
  45. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..for eubacteria in general, such a methicillin resistant Staphylococcus aureus and bioterrorist agents including Burkholderia pseudomallei and Yersinia pestis...
  46. Novel Antibacterials Targeting Gram-negative Nonfermenters
    Michelle M Butler; Fiscal Year: 2010
    ..species, including such Gram-negative nonfermenters as Acinetobacter baumannii, Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia...
  47. Mechanisms of Ferritin-iron Acquisition and Burkholderia pseudomallei Infection.
    Herbert P Schweizer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei (Bp) is an emerging Gram-negative bacterial pathogen that is found with increasing frequency in tropical and subtropical regions of the world...
  48. Construction of (A)BSL-3 Laboratory of Infectious Diseases at the University of S
    Samuel J Strada; Fiscal Year: 2010
    ..research programs on human Select Agent pathogens of the genus Rickettsia and has recently expanded to include Burkholderia Select Agent pathogens. The proposed facility will address two problems associated with the LMB...
  49. Pacific Southwest RCE for Biodefense &Emerging Infectious Diseases Research
    Alan G Barbour; Fiscal Year: 2013
    ..dengue, (2) viral zoonoses, including arenaviruses and Nipah virus, (3) botulinum neurotoxin, (4) Category B Burkholderia species, (5) tularemia, (6) coccidioidomycosis, and (7) reservoir-targeted vaccines for prevention of human ..
  50. Functional Genomics of Single- and Mixed-Species Biofilms in Spatiotemporal Scale
    Tung T Hoang; Fiscal Year: 2013
    ..Herein, we further proposed single- and mixed-species biofilm models of Pa and Burkholderia cenocepacia (Bc) to begin the process of unraveling the spatiotemporal global gene-expression pattern that ..
  51. Regulation of Burkholderia mallei virulence genes
    William Nierman; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Burkholderia mallei, the etiologic agent of glanders, is an obligate parasite of horses, mules and donkeys, and is classified as a Category B agent by the Centers for Disease Control and Prevention ..
  52. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..b>Burkholderia pseudomallei (BP) is a Biosafety level 3 pathogen that is normally a saprophyte of soil and water in tropical ..
  53. Hexameric PBGS as a Bioterrorism Defense
    Eileen Jaffe; Fiscal Year: 2006
    ..is proposed as a basis for discovery of new antimicrobials directed against the NIAID priority pathogens Burkholderia pseudomallei, Brucella mefitensis, Burkholderia mallei, Rickettsia prowazekii, Vibrio cholerae, and Yersinia ..
  54. Role of Burkholderia Cenocepacia Adhesin, AdhA, in Cystic Fibrosis Infections
    Joanna B Goldberg; Fiscal Year: 2010
    ..is responsible for most lung infections, affecting >80% of CF patients;however, bacteria belonging to the Burkholderia cepacia complex (Bcc) have emerged as life-threatening respiratory pathogens...
  55. PSEUDOMONAS 1999--BIOTECHNOLOGY AND PATHOGENESIS
    JOANNA GOLDBERG; Fiscal Year: 1999
    ..P. aeruginosa and Burkholderia (formerly Pseudomonas) cepacia have importance for public health...
  56. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2012
    ..abstract_text> ..
  57. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2011
    ..abstract_text> ..
  58. Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei
    Daniel Altmann; Fiscal Year: 2013
    ..abstract_text> ..
  59. Novel Class of Phospholipases-Molecular Pathogenesis
    Michael Vasil; Fiscal Year: 2007
    ..aeruginosa (2), Mycobacterium tuberculosis (4), Francisella tularensis (1), Burkholderia pseudomallei and mallei (3 each) and Bordetella pertussis (1)...
  60. Non-antiobiotic resistance markers for bacteria
    Herbert Schweizer; Fiscal Year: 2006
    ..of the newly constructed markers for priority pathogen research will be tested by using the examples of Burkholderia mallei, B. pseudomallei, Francisella tulerensis and Yersinia pestis...
  61. Quorum Sensing in Burkholderia mallei
    Josephine R Chandler; Fiscal Year: 2010
    ..QS is important for virulence in many organisms, including the category B bioagent Burkholderia mallei, the causative agent of glanders. Disruption of one of the B...
  62. Antibodies to Burkholderia type III secretion system
    Don Stewart; Fiscal Year: 2005
    ..thailandensis. B.(pseudo)mallei is also a civilian problem causing septicemia in Southeast Asia. Another Burkholderia species, B...
  63. Iron Uptake and Virulence of Burkholderia pseudomallei
    JORGE CROSA; Fiscal Year: 2005
    ..are life threatening infectious diseases with similar patho-physiology caused respectively by the select agents Burkholderia pseudomallei and B. mallei, with dramatic repercussions in the field of bio-defense...
  64. Type IV Pilins as Vaccines against Bioterrorism Threats
    Michael Donnenberg; Fiscal Year: 2004
    ..b>Burkholderia mallei and B...