Summary: A phylum of bacteria consisting of the purple bacteria and their relatives which form a branch of the eubacterial tree. This group of predominantly gram-negative bacteria is classified based on homology of equivalent nucleotide sequences of 16S ribosomal RNA or by hybridization of ribosomal RNA or DNA with 16S and 23S ribosomal RNA.

Top Publications

  1. ncbi Deciphering the rhizosphere microbiome for disease-suppressive bacteria
    Rodrigo Mendes
    Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, Wageningen 6700 EE, Netherlands
    Science 332:1097-100. 2011
  2. pmc A novel lineage of proteobacteria involved in formation of marine Fe-oxidizing microbial mat communities
    David Emerson
    American Type Culture Collection, Manassas, Virginia, United States of America
    PLoS ONE 2:e667. 2007
  3. ncbi Deep-sea vent chemoautotrophs: diversity, biochemistry and ecological significance
    Satoshi Nakagawa
    Subground Animalcule Retrieval Program, Extremobiosphere Research Center, Japan Agency for Marine Earth Science and Technology, Yokosuka, Japan
    FEMS Microbiol Ecol 65:1-14. 2008
  4. pmc Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils
    Naomi L Ward
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Appl Environ Microbiol 75:2046-56. 2009
  5. pmc Host remodeling of the gut microbiome and metabolic changes during pregnancy
    Omry Koren
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Cell 150:470-80. 2012
  6. pmc Lithotrophic iron-oxidizing bacteria produce organic stalks to control mineral growth: implications for biosignature formation
    Clara S Chan
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
    ISME J 5:717-27. 2011
  7. doi AHL-driven quorum-sensing circuits: their frequency and function among the Proteobacteria
    Rebecca J Case
    The Centre of Marine Bio Innovation, University of New South Wales, Sydney, New South Wales, Australia
    ISME J 2:345-9. 2008
  8. pmc Quantitative detection of the nosZ gene, encoding nitrous oxide reductase, and comparison of the abundances of 16S rRNA, narG, nirK, and nosZ genes in soils
    S Henry
    INRA University of Burgundy, Microbiology and Soil Geochemistry, CMSE, 17 rue Sully, B P 86510, 21065 Dijon Cedex, France
    Appl Environ Microbiol 72:5181-9. 2006
  9. ncbi Abundance of Zetaproteobacteria within crustal fluids in back-arc hydrothermal fields of the Southern Mariana Trough
    Shingo Kato
    Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Environ Microbiol 11:3210-22. 2009
  10. pmc Mariprofundus ferrooxydans PV-1 the first genome of a marine Fe(II) oxidizing Zetaproteobacterium
    Esther Singer
    Geomicrobiology Group, Department of Earth Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e25386. 2011

Detail Information

Publications286 found, 100 shown here

  1. ncbi Deciphering the rhizosphere microbiome for disease-suppressive bacteria
    Rodrigo Mendes
    Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, Wageningen 6700 EE, Netherlands
    Science 332:1097-100. 2011
    ..More than 33,000 bacterial and archaeal species were detected, with Proteobacteria, Firmicutes, and Actinobacteria consistently associated with disease suppression...
  2. pmc A novel lineage of proteobacteria involved in formation of marine Fe-oxidizing microbial mat communities
    David Emerson
    American Type Culture Collection, Manassas, Virginia, United States of America
    PLoS ONE 2:e667. 2007
    ..We have used both cultivation and cultivation-independent techniques to study Fe-rich microbial mats associated with hydrothermal venting at Loihi Seamount, a submarine volcano...
  3. ncbi Deep-sea vent chemoautotrophs: diversity, biochemistry and ecological significance
    Satoshi Nakagawa
    Subground Animalcule Retrieval Program, Extremobiosphere Research Center, Japan Agency for Marine Earth Science and Technology, Yokosuka, Japan
    FEMS Microbiol Ecol 65:1-14. 2008
    ..This review summarizes chemoautotrophy in deep-sea vents, highlighting recent biochemical and genomic discoveries...
  4. pmc Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils
    Naomi L Ward
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Appl Environ Microbiol 75:2046-56. 2009
    ..Phylogenetic analysis placed them as a unique phylum. They share genomic traits with members of the Proteobacteria, the Cyanobacteria, and the Fungi. The three strains appear to be versatile heterotrophs...
  5. pmc Host remodeling of the gut microbiome and metabolic changes during pregnancy
    Omry Koren
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Cell 150:470-80. 2012
    ..first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness...
  6. pmc Lithotrophic iron-oxidizing bacteria produce organic stalks to control mineral growth: implications for biosignature formation
    Clara S Chan
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
    ISME J 5:717-27. 2011
    ..We suggest that stalk-like morphologies observed in modern and ancient samples may be correlated confidently with the Fe-oxidizing metabolism as a robust biosignature...
  7. doi AHL-driven quorum-sensing circuits: their frequency and function among the Proteobacteria
    Rebecca J Case
    The Centre of Marine Bio Innovation, University of New South Wales, Sydney, New South Wales, Australia
    ISME J 2:345-9. 2008
  8. pmc Quantitative detection of the nosZ gene, encoding nitrous oxide reductase, and comparison of the abundances of 16S rRNA, narG, nirK, and nosZ genes in soils
    S Henry
    INRA University of Burgundy, Microbiology and Soil Geochemistry, CMSE, 17 rue Sully, B P 86510, 21065 Dijon Cedex, France
    Appl Environ Microbiol 72:5181-9. 2006
    ..The two sets of nosZ primers gave similar gene copy numbers for all tested soils. The maximum abundance of nosZ and nirK relative to 16S rRNA was 5 to 6%, confirming the low proportion of denitrifiers to total bacteria in soils...
  9. ncbi Abundance of Zetaproteobacteria within crustal fluids in back-arc hydrothermal fields of the Southern Mariana Trough
    Shingo Kato
    Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Environ Microbiol 11:3210-22. 2009
    ..Our results lead to the hypothesis that the Zetaproteobacteria play a role in iron oxidation within the oceanic crust...
  10. pmc Mariprofundus ferrooxydans PV-1 the first genome of a marine Fe(II) oxidizing Zetaproteobacterium
    Esther Singer
    Geomicrobiology Group, Department of Earth Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e25386. 2011
    ..This study has provided novel insights into the molecular nature of Zetaproteobacteria...
  11. ncbi Living without Fur: the subtlety and complexity of iron-responsive gene regulation in the symbiotic bacterium Rhizobium and other alpha-proteobacteria
    Andrew W B Johnston
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Biometals 20:501-11. 2007
    The alpha-proteobacteria include several important genera, including the symbiotic N(2)-fixing "rhizobia", the plant pathogen Agrobacterium, the mammalian pathogens Brucella, Bartonella as well as many others that are of environmental or ..
  12. ncbi Bacterial diversity and activity along a salinity gradient in soda lakes of the Kulunda Steppe (Altai, Russia)
    Mirjam J Foti
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Extremophiles 12:133-45. 2008
    ..showed the presence of minor, but highly active microbial populations, mostly represented by members of the Proteobacteria. Remarkably high SRR were measured at hypersaline conditions (200 g L(-1))...
  13. ncbi Horizontal transfer of the photosynthesis gene cluster and operon rearrangement in purple bacteria
    N Igarashi
    Department of Biology, Tokyo Metropolitan University, Minamiohsawa 1-1, Hachioji, Tokyo 192-0397, Japan
    J Mol Evol 52:333-41. 2001
    ..gene cluster was sequenced in a photosynthetic bacterium belonging to the beta subclass of purple bacteria (Proteobacteria), Rubrivivax gelatinosus...
  14. ncbi Amyloid adhesins are abundant in natural biofilms
    Poul Larsen
    Department of Biotechnology, Aalborg University, Sohngaardsholmvej 57, DK 9000, Aalborg, Denmark
    Environ Microbiol 9:3077-90. 2007
    ..natural habitats, bacteria producing extracellular amyloid adhesins were identified within several phyla: Proteobacteria (Alpha-, Beta-, Gamma- and Deltaproteobacteria), Bacteriodetes, Chloroflexi and Actinobacteria, and most ..
  15. ncbi Diversity and function of epibiotic microbial communities on the galatheid crab, Shinkaia crosnieri
    Tomo o Watsuji
    Subsurface Geobiology Advanced Research Team SUGAR, Extremobiosphere Research Program XBR, Japan Agency for Marine Earth Science and Technology JAMSTEC, 2 15 Natsushima cho, Yokosuka 237 0061
    Microbes Environ 25:288-94. 2010
    ..In conclusion, the uptake experiments suggested that sulfur-oxidizing chemolithoautotrophic and methanotrophic production by the epibionts provides the nutrition for S. crosnieri...
  16. ncbi Molecular characterization of putative biocorroding microbiota with a novel niche detection of Epsilon- and Zetaproteobacteria in Pacific Ocean coastal seawaters
    Hongyue Dang
    State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology, China University of Petroleum East China, Qingdao 266555, China
    Environ Microbiol 13:3059-74. 2011
    ..Further studies of Epsilon- and Zetaproteobacteria in particular may thus help with the design of effective corrosion prevention and control strategies...
  17. ncbi Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice
    Frederic A Carvalho
    Center for Inflammation, Immunity, and Infection, Georgia State University, Atlanta, 30303, USA
    Cell Host Microbe 12:139-52. 2012
    ..Transient high levels of proteobacteria, especially enterobacteria species including E...
  18. ncbi New evidence for bacterial diversity in the ascoma of the ectomycorrhizal fungus Tuber borchii Vittad
    Elena Barbieri
    Istituto di Chimica Biologica Giorgio Fornaini, University of Urbino Carlo Bo, Urbino PU, Italy
    FEMS Microbiol Lett 247:23-35. 2005
    ..Most of the isolates were affiliated to the gamma-Proteobacteria, mainly Fluorescent pseudomonads; some isolates were members of the Bacteroidetes group and Gram-positive ..
  19. pmc Biochemical evidence for formate transfer in syntrophic propionate-oxidizing cocultures of Syntrophobacter fumaroxidans and Methanospirillum hungatei
    Frank A M de Bok
    Laboratory of Microbiology, Wageningen University, The Netherlands
    Appl Environ Microbiol 68:4247-52. 2002
    ..fumaroxidans cultures that exhibited the highest formate dehydrogenase activities. The results suggest that formate is the preferred electron carrier in syntrophic propionate-oxidizing cocultures of S. fumaroxidans and M. hungatei...
  20. ncbi Occurrence and diversity of bacterial communities in Tuber magnatum during truffle maturation
    Elena Barbieri
    Istituto di Chimica Biologica Giorgio Fornaini, Via Saffi, 2, University of Urbino Carlo Bo, 61029 Urbino, Italy
    Environ Microbiol 9:2234-46. 2007
    ..Sequencing results from the clone library showed a significant presence of alpha-Proteobacteria (634 of the 771 total clones screened, c. 82%) affiliated with Sinorhizobium, Rhizobium and Bradyrhizobium spp...
  21. ncbi Bacterial diversity in Fe-rich hydrothermal sediments at two South Tonga Arc submarine volcanoes
    N L Forget
    Department of Biology, University of Victoria, Petch Building 116, 3800 Finnerty Rd, Victoria, BC, Canada
    Geobiology 8:417-32. 2010
    ..The results of this study suggest that Fe-rich hydrothermal sediments, while dominated by Fe oxidizers, can be exploited by a variety of autotrophic and heterotrophic micro-organisms...
  22. ncbi Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110
    Takakazu Kaneko
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0812, Japan
    DNA Res 9:189-97. 2002
    ..These observations suggest plasticity of the B. japonicum genome, which is probably due to complex genome rearrangements such as horizontal transfer and insertion of various DNA elements, and to homologous recombination...
  23. ncbi Phylogeny of Proteobacteria and Bacteroidetes from oxic habitats of a tidal flat ecosystem
    Heike Stevens
    Institute for Chemistry and Biology of the Marine Environment ICBM, University of Oldenburg, P O Box 2503, D 26111 Oldenburg, Germany
    FEMS Microbiol Ecol 54:351-65. 2005
    Bacteria of the phyla Proteobacteria and Bacteroidetes are known to be the most prominent heterotrophic organisms in marine surface waters...
  24. ncbi Distribution and selection of poly-3-hydroxybutyrate production capacity in methanotrophic proteobacteria
    Allison J Pieja
    Environmental Engineering and Science, Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305, USA
    Microb Ecol 62:564-73. 2011
  25. ncbi Characterization of the first alginolytic operons in a marine bacterium: from their emergence in marine Flavobacteriia to their independent transfers to marine Proteobacteria and human gut Bacteroides
    François Thomas
    UPMC University Paris 6, UMR 7139 Marine Plants and Biomolecules, Station Biologique de Roscoff, F 29682 Roscoff, Brittany, France
    Environ Microbiol 14:2379-94. 2012
    ..operons originated from an ancestral marine flavobacterium and were independently transferred to marine proteobacteria and Japanese gut Bacteroides...
  26. pmc The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov
    Stefan Spring
    Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    PLoS ONE 4:e4866. 2009
    ..The interaction of photosynthesis and carbon metabolism in these interesting bacteria is still largely unknown and requires further investigation in order to estimate their contribution to the marine carbon cycle...
  27. ncbi Abundance, composition, diversity and novelty of soil Proteobacteria
    Anne M Spain
    Department of Botany and Microbiology and Institute for Energy and the Environment, University of Oklahoma, Norman, OK, USA
    ISME J 3:992-1000. 2009
    ..This study offers a detailed phylogenetic analysis of the Proteobacteria-affiliated clones identified from 13,001 nearly full-length 16S rRNA gene clones derived from Oklahoma tall-..
  28. pmc Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria
    Jeffrey W Craig
    Howard Hughes Medical Institute, Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Appl Environ Microbiol 76:1633-41. 2010
    ..studies, we report the phenotypic screening of broad-host-range environmental DNA libraries in six different proteobacteria: Agrobacterium tumefaciens, Burkholderia graminis, Caulobacter vibrioides, Escherichia coli, Pseudomonas ..
  29. pmc Transposon mutagenesis in purple sulfur photosynthetic bacteria: identification of hypF, encoding a protein capable of processing [NiFe] hydrogenases in alpha, beta, and gamma subdivisions of the proteobacteria
    B Fodor
    Institute of Biophysics, Biological Research Center, Hungarian Academy of Sciences, and Department of Biotechnology, University of Szeged, H 6726 Szeged, Hungary
    Appl Environ Microbiol 67:2476-83. 2001
    ..RT-PCR data suggested that HypF has no effect on the transcriptional regulation of the structural genes of hydrogenases in this organism...
  30. pmc Cultivation of denitrifying bacteria: optimization of isolation conditions and diversity study
    Kim Heylen
    Laboratory of Microbiology, Department of Biochemistry, Physiology and Microbiology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Appl Environ Microbiol 72:2637-43. 2006
    ..This study revealed a much more diverse denitrifying community than that previously described in cultivation-dependent research on activated sludge...
  31. pmc Molecular characterization of methanotrophic isolates from freshwater lake sediment
    A J Auman
    Departments of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Appl Environ Microbiol 66:5259-66. 2000
    ..The presence of sMMO-containing Methylomonas strains in a pristine freshwater lake environment suggests that these methanotrophs are more widespread than has been previously thought...
  32. ncbi Diversity and quorum-sensing signal production of Proteobacteria associated with marine sponges
    Naglaa M Mohamed
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Environ Microbiol 10:75-86. 2008
    ..Given that marine Proteobacteria are known to produce N-acyl homoserine lactone (AHL) signal molecules, we tested the production of AHLs by ..
  33. pmc Improved culturability of soil bacteria and isolation in pure culture of novel members of the divisions Acidobacteria, Actinobacteria, Proteobacteria, and Verrucomicrobia
    Peter H Janssen
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Appl Environ Microbiol 68:2391-6. 2002
    ..A large proportion of these isolates represent the first known isolates of globally distributed groups of soil bacteria belonging to novel lineages within the divisions Actinobacteria, Acidobacteria, Proteobacteria, and Verrucomicrobia.
  34. pmc Unexpected diversity and complexity of the Guerrero Negro hypersaline microbial mat
    Ruth E Ley
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Appl Environ Microbiol 72:3685-95. 2006
    ..The sequences determined in this study have been submitted to the GenBank database and assigned accession numbers DQ 329539 to DQ 331020, and DQ 397339 to DQ 397511...
  35. ncbi Molecular analyses of the microbial community composition of an anoxic basin of a municipal wastewater treatment plant reveal a novel lineage of proteobacteria
    Rakia Chouari
    Faculte des Sciences de Bizerte, Université 7 Novembre à Carthage, Bizerte, Tunisia
    Microb Ecol 60:272-81. 2010
    ..The Proteobacteria phylum is the most abundant and diversified phylogenetic group representing 60...
  36. ncbi Multiple Rubisco forms in proteobacteria: their functional significance in relation to CO2 acquisition by the CBB cycle
    Murray Ronald Badger
    Molecular Plant Physiology Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT, Australia
    J Exp Bot 59:1525-41. 2008
    ..The most dramatic evidence of this is the occurrence of multiple forms of Rubisco within autotrophic proteobacteria, where Forms II, IC, IBc, IAc, and IAq can be found either singly or in multiple combinations within a ..
  37. pmc Genomes on the shrink
    Howard Ochman
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 102:11959-60. 2005
  38. ncbi Responses of benthic bacteria to experimental drying in sediments from Mediterranean temporary rivers
    Stefano Amalfitano
    Water Research Institute IRSA CNR, Via Reno 1, 00198 Rome, Italy
    Microb Ecol 55:270-9. 2008
    ..Community composition analysis showed a relative increase in alpha- and beta-Proteobacteria, when passing from wet to dry conditions...
  39. ncbi High-diversity biofilm for the oxidation of sulfide-containing effluents
    I Ferrera
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain
    Appl Microbiol Biotechnol 64:726-34. 2004
    ..The clone library was dominated by alpha-Proteobacteria (mostly Rhodobacter group), followed by gamma-Proteobacteria (Chromatiaceae-like and Thiothrix-like aerobic ..
  40. pmc Remarkable diversity of phototrophic purple bacteria in a permanently frozen Antarctic lake
    Elizabeth A Karr
    Department of Microbiology, Southern Illinois University, Carbondale, Illinois 62901 6508, USA
    Appl Environ Microbiol 69:4910-4. 2003
    ..The isolates also contained gas vesicles, buoyancy structures previously unknown in purple nonsulfur bacteria, that may be necessary for these organisms to position themselves at specific depths within the nearly freezing water column...
  41. ncbi Comparison of cultivation-dependent and molecular methods for studying the diversity of anoxygenic purple phototrophs in sediments of an eutrophic brackish lagoon
    Anthony Ranchou-Peyruse
    Laboratoire d Ecologie Moléculaire Microbiologie, EA3525, Universite de Pau et des Pays de l Adour, 64013 Pau Cedex, France
    Environ Microbiol 8:1590-9. 2006
  42. ncbi Vertical distribution of bacteria in a lake sediment from Antarctica by culture-independent and culture-dependent approaches
    Sisinthy Shivaji
    Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Res Microbiol 162:191-203. 2011 the phyla level using T-RFLP and 16S rRNA clone libraries was similar and clones were affiliated with Proteobacteria, Bacteroidetes, Actinobacteria and Firmicutes...
  43. ncbi Proteobacteria-like ferrochelatase in the malaria parasite
    Shigeharu Sato
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK
    Curr Genet 42:292-300. 2003
    ..This suggests an unusual intracellular distribution of heme biosynthetic enzymes, involving multiple subcellular compartments...
  44. pmc In silico prediction of human pathogenicity in the γ-proteobacteria
    Massimo Andreatta
    Center for Biological Sequence Analysis, Technical University of Denmark, Kongens Lyngby, Denmark
    PLoS ONE 5:e13680. 2010
    ..Bioinformatics-based methods are therefore strongly needed to mine the fast growing number of genome sequences and assess in a rapid and reliable way the pathogenicity of novel bacteria...
  45. ncbi Biochemical Society Special Lecture. Nitrate- and nitrite-responsive sensors NarX and NarQ of proteobacteria
    V Stewart
    Section of Microbiology, University of California, 1 Shields Avenue, Davis, CA 95616 8665, USA
    Biochem Soc Trans 31:1-10. 2003
    ..Several other species classified in the gamma and beta subdivisions of the proteobacteria contain only a single Nar two-component regulatory pair...
  46. ncbi IBD-what role do Proteobacteria play?
    Indrani Mukhopadhya
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nat Rev Gastroenterol Hepatol 9:219-30. 2012
    ..Microbial diversity studies have continually demonstrated an expansion of the Proteobacteria phylum in patients with IBD...
  47. ncbi Bacterial diversity based on 16S rRNA and gyrB genes at Yinshan mine, China
    Huaqun Yin
    School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan, China
    Syst Appl Microbiol 31:302-11. 2008
    ..Moreover, the Mantel test showed that the geochemical characteristics, especially the pH value and the concentration of iron, strongly influenced the composition of the microbial communities...
  48. ncbi Sulfur-oxidizing chemolithotrophic proteobacteria dominate the microbiota in high arctic thermal springs on Svalbard
    Laila Johanne Reigstad
    Center for Geobiology, Department of Biology, University of Bergen, Bergen, Norway
    Astrobiology 11:665-78. 2011
  49. ncbi Chemical characterization of lipid A from some marine proteobacteria
    I N Krasikova
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, pr 100 letiya Vladivostoka 159, Vladivostok, 690022 Russia
    Biochemistry (Mosc) 66:1047-54. 2001
    Lipids A from type and wild strains of marine Proteobacteria belonging to Alteromonadaceae (Alteromonas (1 species), Idiomarina (1 species), and Pseudoalteromonas (8 species) genera) and Vibrionaceae (Shewanella (1 species) and Vibrio (1 ..
  50. ncbi Phylogeny of the 1-aminocyclopropane-1-carboxylic acid deaminase-encoding gene acdS in phytobeneficial and pathogenic Proteobacteria and relation with strain biogeography
    Didier Blaha
    UMR CNRS 5557 Ecologie Microbienne, Universite Claude Bernard, Villeurbanne, France
    FEMS Microbiol Ecol 56:455-70. 2006
    ..Two clusters gathered both Betaprotobacteria and Gammaproteobacteria, suggesting extensive horizontal transfers of acdS, noticeably between plant-associated Proteobacteria.
  51. ncbi Periplasmic glucans isolated from Proteobacteria
    Sanghoo Lee
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, Seoul 143 701, Korea
    BMB Rep 42:769-75. 2009
    Periplasmic glucans (PGs) are general constituents in the periplasmic space of Proteobacteria. PGs from bacterial strains are found in larger amounts during growth on medium with low osmolarity and thus are often been specified as ..
  52. pmc Diversity of microorganisms in Fe-As-rich acid mine drainage waters of Carnoulès, France
    O Bruneel
    Laboratoire Hydrosciences Montpellier, UMR5569, Universite Montpellier 2, Place E Bataillon, Case MSE, 34095 Montpellier Cedex 05, France
    Appl Environ Microbiol 72:551-6. 2006
    ..The description of the bacterial community structure and its dynamics lead to a better understanding of the natural remediation processes occurring at this site...
  53. ncbi Rapid and simultaneous detection of linear chromosome and large plasmids in Proteobacteria
    Martha Helena Ramírez-Bahena
    Université de Lyon Université Lyon, Lyon, France
    J Basic Microbiol 52:736-9. 2012
  54. ncbi The iron-oxidizing proteobacteria
    Sabrina Hedrich
    School of Biological Sciences, College of Natural Sciences, Bangor University, Deiniol Road, Bangor LL57 2UW, UK
    Microbiology 157:1551-64. 2011
    ..While species of iron-oxidizing bacteria can be found in many different phyla, most are affiliated with the Proteobacteria. The latter can be subdivided into four main physiological groups: (i) acidophilic, aerobic iron oxidizers; (..
  55. ncbi New computational methods reveal tRNA identity element divergence between Proteobacteria and Cyanobacteria
    Eva Freyhult
    The Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, 751 24 Uppsala, Sweden
    Biochimie 89:1276-88. 2007
    ..Here we show evidence that determinants for lysylated isoleucine tRNAs are not the same in Proteobacteria as in other bacterial groups including the Cyanobacteria...
  56. pmc Relative abundances of proteobacterial membrane-bound and periplasmic nitrate reductases in selected environments
    D Bru
    INRA, University of Burgundy, Soil and Environmental Microbiology, CMSE, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France
    Appl Environ Microbiol 73:5971-4. 2007
    ..8 x 10(4) copies per ng of DNA. This study provides evidence that, in soil samples, the number of proteobacteria carrying the napA gene is often as high as that of proteobacteria carrying the narG gene...
  57. ncbi Osmoregulated periplasmic glucans in Proteobacteria
    J P Bohin
    Laboratoire de Chimie Biologique, CNRS UMR 8576, Universite des Sciences et Technologies de Lille, 59655, Villeneuve d Ascq, France
    FEMS Microbiol Lett 186:11-9. 2000
    Large amounts of osmoregulated periplasmic glucans (OPGs) are found in the periplasmic space of Proteobacteria. Four families of OPGs are described on the basis of structural features of the polyglucose backbone...
  58. ncbi The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes
    R S Gupta
    Department of Biochemistry, McMaster University, L8N 3Z5, Hamilton, Ont, Canada
    FEMS Microbiol Rev 24:367-402. 2000
    The evolutionary relationships of proteobacteria, which comprise the largest and phenotypically most diverse division among prokaryotes, are examined based on the analyses of available molecular sequence data...
  59. pmc PyCogent: a toolkit for making sense from sequence
    Rob Knight
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, USA
    Genome Biol 8:R171. 2007
    ..The toolkit takes advantage of parallel architectures and runs on a range of hardware and operating systems, and is available under the general public license from
  60. ncbi Cultivation of globally distributed soil bacteria from phylogenetic lineages previously only detected in cultivation-independent surveys
    Michelle Sait
    Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
    Environ Microbiol 4:654-66. 2002
  61. pmc DddY, a periplasmic dimethylsulfoniopropionate lyase found in taxonomically diverse species of Proteobacteria
    Andrew R J Curson
    School of Biological Sciences, University of East Anglia, Norwich, UK
    ISME J 5:1191-200. 2011
    ..There are dddY-like genes in strains of Alcaligenes, Arcobacter and Shewanella, in the β-, ɛ- and γ-proteobacteria, respectively...
  62. pmc The genus Caedibacter comprises endosymbionts of Paramecium spp. related to the Rickettsiales (Alphaproteobacteria) and to Francisella tularensis (Gammaproteobacteria)
    Cora L Beier
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 85350 Freising, Germany
    Appl Environ Microbiol 68:6043-50. 2002
    ..comprises at least two phylogenetically different bacterial species belonging to two different classes of the PROTEOBACTERIA: Comparative phylogenetic analysis of C...
  63. ncbi Detection of methanogens and proteobacteria from a single cell of rumen ciliate protozoa
    Chagan Irbis
    Laboratory of Animal Science, Kyoto Prefectural University, Kyoto 606 8522, Japan
    J Gen Appl Microbiol 50:203-12. 2004
    ..A range of proteobacteria was retrieved from cells of P. multivesiculatum...
  64. pmc Fingerprinting diazotroph communities in the Chesapeake Bay by using a DNA macroarray
    Bethany D Jenkins
    University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Appl Environ Microbiol 70:1767-76. 2004
    ..M. Short, B. D. Jenkins, and J. P. Zehr, Appl. Environ. Microbiol., in press). The results show that DNA macroarrays have great potential for mapping the spatial and temporal variability of functional gene diversity in the environment...
  65. ncbi Widespread distribution of a lexA-regulated DNA damage-inducible multiple gene cassette in the Proteobacteria phylum
    Marc Abella
    Departament de Genetica i Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Mol Microbiol 54:212-22. 2004
    ..In addition, in silico analyses reveal that this multiple gene cassette is also present in many Proteobacteria families, and that both its gene content and LexA-binding sequence have evolved over time, ultimately giving ..
  66. pmc Neutrophilic iron-oxidizing "zetaproteobacteria" and mild steel corrosion in nearshore marine environments
    Joyce M McBeth
    Bigelow Laboratory for Ocean Sciences, Box 475, 180 McKown Point Road, West Boothbay Harbor, ME 04575, USA
    Appl Environ Microbiol 77:1405-12. 2011
    ..In addition, this work shows that the global distribution of Zetaproteobacteria is far greater than previously thought...
  67. ncbi Distinguishable codon usage and amino acid composition patterns among substrates of leaderless secretory pathways from proteobacteria
    Ināra Kampenusa
    Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia, Kronvalda boulevard 4, LV 1010 Riga, Latvia
    Appl Microbiol Biotechnol 86:285-93. 2010
    ..from the 111 annotated sequences of leaderless secreted type I, type III, type IV, and type VI proteins from proteobacteria were subjected to the forward and backward selection to obtain a combination of most effective predictor ..
  68. pmc The dif/Xer recombination systems in proteobacteria
    Christophe Carnoy
    Inserm U801, Lille, France
    PLoS ONE 4:e6531. 2009
    ..The aim of the present study was to extensively characterize the dif/Xer system in the proteobacteria, since this taxon accounts for the majority of genomes sequenced to date...
  69. ncbi Chemical communication in proteobacteria: biochemical and structural studies of signal synthases and receptors required for intercellular signalling
    Katherine M Pappas
    Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece
    Mol Microbiol 53:755-69. 2004
    ..One class of chemical signals widely used by proteobacteria consists of N-acyl-homoserine lactones, which are synthesized by proteins related to LuxI of Vibrio fischeri ..
  70. pmc Comparison of ATPase-encoding type III secretion system hrcN genes in biocontrol fluorescent Pseudomonads and in phytopathogenic proteobacteria
    Fabio Rezzonico
    Phytopathology Group, Institute of Plant Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Appl Environ Microbiol 70:5119-31. 2004
    Type III protein secretion systems play a key role in the virulence of many pathogenic proteobacteria, but they also occur in nonpathogenic, plant-associated bacteria. Certain type III protein secretion genes (e.g...
  71. pmc Highly divergent RfaH orthologs from pathogenic proteobacteria can substitute for Escherichia coli RfaH both in vivo and in vitro
    Heather D Carter
    Department of Microbiology, The Ohio State University, 376 BioSciences Building, 484 West 12th Avenue, Columbus, OH 43210, USA
    J Bacteriol 186:2829-40. 2004
    ..coli gene. Thus, despite the apparently accelerated divergent evolution of the RfaH proteins, the mechanism of their action is conserved well enough to make them transcriptionally active in the E. coli system...
  72. ncbi Endophytic bacterial diversity in poplar trees growing on a BTEX-contaminated site: the characterisation of isolates with potential to enhance phytoremediation
    Fiona Porteous Moore
    Macaulay Institute, Craigiebuckler, Aberdeen, Scotland, AB15 8QH, UK
    Syst Appl Microbiol 29:539-56. 2006
    ..This study demonstrates that within the diverse bacterial communities found in poplar several endophytic strains are present that have the potential to enhance phytoremediation strategies...
  73. ncbi Stepwise evolution of the Sec machinery in Proteobacteria
    Eli O van der Sluis
    Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands
    Trends Microbiol 14:105-8. 2006
    ..In several of the Proteobacteria, this machinery contains accessory features that are not present in any other bacterial division...
  74. ncbi PpsR: a multifaceted regulator of photosynthesis gene expression in purple bacteria
    Sylvie Elsen
    Laboratoire de Biochimie et Biophysique des Systèmes Intégrés UMR 5092 CNRS CEA UJF, CEA Grenoble, 38054 Grenoble Cedex 9, France
    Mol Microbiol 57:17-26. 2005
  75. ncbi CHDL: a cadherin-like domain in Proteobacteria and Cyanobacteria
    Lihuan Cao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai 200433, PR China
    FEMS Microbiol Lett 251:203-9. 2005
    ..The CHDL domain is mostly distributed in Proteobacteria and Cyanobacteria, although it is also found in some eukaryotic proteins...
  76. ncbi Identification of disulfide reductases in Campylobacterales: a bioinformatics investigation
    Nadeem O Kaakoush
    School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Antonie Van Leeuwenhoek 92:429-41. 2007
    ..TrxB(1) proteins were more closely related to those of Firmicutes than to the corresponding proteins of other Proteobacteria. The Campylobacterales TrxB(2) proteins were closer to glutathione reductases of other organisms than to their ..
  77. ncbi ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria
    Christian Schlieker
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Biol Chem 386:1115-27. 2005
    ..typhimurium or Yersinia pseudotuberculosis ClpV strongly reduce the ability of these pathogenic bacteria to invade epithelial cells. We propose a role of this novel and unique class of AAA+ proteins in bacteria-host cell interactions...
  78. ncbi The origin and evolution of operons: the piecewise building of the proteobacterial histidine operon
    Renato Fani
    Dipartimento di Biologia Animale e Genetica, Firenze, Italy
    J Mol Evol 60:378-90. 2005
    The structure and organization of 470 histidine biosynthetic genes from 47 different proteobacteria were combined with phylogenetic inference to investigate the mechanisms responsible for assembly of the his pathway and the origin of his ..
  79. ncbi Profiling the secretomes of plant pathogenic Proteobacteria
    Gail M Preston
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    FEMS Microbiol Rev 29:331-60. 2005
  80. pmc Protein domains and architectural innovation in plant-associated Proteobacteria
    David J Studholme
    The Sainsbury Laboratory, Norwich, NR4 7UH, UK
    BMC Genomics 6:17. 2005
    ..This observation motivated an investigation of the relationship between an organism's lifestyle and the complement of domains and domain architectures found within its proteome...
  81. pmc Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria
    Leila Mamirova
    Institute for Information Transmission Problems RAS, Bolshoi Karetny pereulok 19, Moscow 127994, Russia
    BMC Evol Biol 7:17. 2007
    ..Here we analyze the influence of these two factors on the strength of the purifying selection in mitochondrial and proteobacterial orthologous genes taking into account the differences in the organism lifestyles...
  82. ncbi Potent cytotoxins produced by a microbial symbiont protect host larvae from predation
    Nicole Lopanik
    Graduate College of Marine Studies, University of Delaware, Lewes, DE 19958, USA
    Oecologia 139:131-9. 2004
  83. ncbi Selection for highly biased amino acid frequency in the TolA cell envelope protein of Proteobacteria
    Alejandro P Rooney
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 North University Street, Peoria, IL 61604, USA
    J Mol Evol 57:731-6. 2003
    ..However, this study shows that selection has acted to maintain high levels of alanine and lysine in the TolA protein of Proteobacteria, which in turn has biased nucleotide composition in the corresponding tolA gene.
  84. pmc DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria
    Nicholas P Tucker
    John Innes Centre, Colney, Norwich, United Kingdom
    J Bacteriol 186:6656-60. 2004
    ..The derived consensus sequence for NorR binding sites was used to search for novel members of the E. coli NorR regulon and to show that NorR binding sites are partially conserved in other members of the proteobacteria.
  85. ncbi Polymorphic proteins of Chlamydia spp.--autotransporters beyond the Proteobacteria
    I R Henderson
    Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Trends Microbiol 9:573-8. 2001
    ..resemble members of the autotransporter family, and we suggest that they follow the same secretion pathway...
  86. ncbi Genomes in flux: the evolution of archaeal and proteobacterial gene content
    Berend Snel
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genome Res 12:17-25. 2002
    ..Here we reconstruct the gene content of ancestral Archaea and Proteobacteria and quantify the processes connecting them to their present day representatives based on the distribution of ..
  87. ncbi Succinate:quinone oxidoreductases from epsilon-proteobacteria
    C Roy D Lancaster
    Max Planck Institute of Biophysics, Department of Molecular Membrane Biology, Frankfurt am Main, Germany
    Biochim Biophys Acta 1553:84-101. 2002
    The epsilon-proteobacteria form a subdivision of the Proteobacteria including the genera Wolinella, Campylobacter, Helicobacter, Sulfurospirillum, Arcobacter and Dehalospirillum...
  88. ncbi Identification of a unique IAHP (IcmF associated homologous proteins) cluster in Vibrio cholerae and other proteobacteria through in silico analysis
    Soumita Das
    Human Genetics and Genomics Group, Indian Institute of Chemical Biology, Calcutta, India
    In Silico Biol 3:287-300. 2003
    ..cholerae though the relative position of respective ORFs are the same. In other proteobacteria like M. loti, A. tumefaciens, P. aeruginosa and S...
  89. ncbi [Computer analysis of regulating metabolism of glycerol-3-phosphate in proteobacteria genome]
    L V Danilova
    Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, 101447 Russia
    Mol Biol (Mosk) 37:843-9. 2003
    ..responsible for metabolism of glycerol and glycerol-3-phosphate in genomes of alpha-, beta-, and gamma-proteobacteria. New palindromic GlpR-binding signals were identified in gamma-proteobacteria; consensus sequences being ..
  90. pmc OGtree: a tool for creating genome trees of prokaryotes based on overlapping genes
    Li Wei Jiang
    Institute of Bioinformatics and Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan
    Nucleic Acids Res 36:W475-80. 2008
    ..OGtree is available online at
  91. pmc Proteorhodopsin genes are distributed among divergent marine bacterial taxa
    José R de la Torre
    Monterey Bay Aquarium Research Institute, 7700 Sandholdt Road, Moss Landing, CA 95039, USA
    Proc Natl Acad Sci U S A 100:12830-5. 2003
    ..PR genes are distributed among a variety of divergent marine bacterial taxa, including both alpha- and gamma-proteobacteria. Our analyses also demonstrate the utility of cultivation-independent comparative genomic approaches for ..
  92. ncbi Amino acid sequences and distribution of high-potential iron-sulfur proteins that donate electrons to the photosynthetic reaction center in phototropic proteobacteria
    G Van Driessche
    Department of Biochemistry, Physiology and Microbiology, Laboratory for Protein Biochemistry and Protein Engineering, University of Ghent, 9000 Ghent, Belgium
    J Mol Evol 57:181-99. 2003
    ..between the cytochrome bc1 complex and the reaction-center bacteriochlorophyll in some species of phototrophic proteobacteria, a role traditionally assigned to cytochrome c2...
  93. pmc Comparative genomics of regulation of fatty acid and branched-chain amino acid utilization in proteobacteria
    Alexey E Kazakov
    Institute for Information Transmission Problems, RAS, Moscow, Russia
    J Bacteriol 191:52-64. 2009 identify candidate transcriptional factors and DNA motifs that control ILV and FA utilization pathways in proteobacteria. The metabolic regulons were characterized based on the identification and comparison of candidate ..
  94. ncbi Culturable aerobic bacteria from the upstream region of a karst water rivulet
    Sylvie Cousin
    German Collection of Microorganisms and Cell Cultures GmbH DSMZ, Braunschweig, Germany
    Int Microbiol 11:91-100. 2008
    ..showed that the isolates included members of Bacteriodetes (especially the genus Flavobacterium) and Proteobacteria (mainly Pseudomonas and Stenotrophomonas)...
  95. pmc A DNA element recognised by the molybdenum-responsive transcription factor ModE is conserved in Proteobacteria, green sulphur bacteria and Archaea
    David J Studholme
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    BMC Microbiol 3:24. 2003
    ..In E. coli and other Proteobacteria molybdenum metabolism and homeostasis are regulated by the molybdate-responsive transcription factor ModE.
  96. pmc Coexistence of multiple proteobacterial endosymbionts in the gills of the wood-boring Bivalve Lyrodus pedicellatus (Bivalvia: Teredinidae)
    Daniel L Distel
    Department of Biochemistry, Microbiology, and Molecular Biology, University of Maine, Orono 04469, USA
    Appl Environ Microbiol 68:6292-9. 2002
    ..turnerae. Phylogenetic analyses indicate that the three newly detected ribotypes are derived from gamma proteobacteria that are related to but distinct (>6.5% sequence divergence) from T. turnerae...
  97. ncbi Structures of polysaccharides and oligosaccharides of some Gram-negative marine Proteobacteria
    Evgeny L Nazarenko
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 690022, Russian Federation
    Carbohydr Res 338:2449-57. 2003
    ..the genera Pseudoalteromonas and Shewanella belonging to the Alteromonadaceae family and gamma-subclass of Proteobacteria, are reviewed. The polysaccharides are distinguished by the acidic character (e.g...
  98. pmc Degradation of polycyclic aromatic hydrocarbons at low temperature under aerobic and nitrate-reducing conditions in enrichment cultures from northern soils
    Mikael Eriksson
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Appl Environ Microbiol 69:275-84. 2003
    ..e., different species or subspecies). The composition of the enriched communities appeared to be more affected by presence of oxygen, than by temperature or source of the inoculum...
  99. ncbi Phylogenetic characterization of epibiotic bacteria in the accessory nidamental gland and egg capsules of the squid Loligo pealei (Cephalopoda:Loliginidae)
    E Barbieri
    The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Environ Microbiol 3:151-67. 2001
    ..hybridization (FISH) and 16S rDNA analysis showed that predominantly alpha- and, to a lesser extent, gamma-proteobacteria were the predominant components of the ANG and EC bacterial communities...
  100. ncbi Molecular ecology of nifH genes and transcripts in the eastern Mediterranean Sea
    Dikla Man-Aharonovich
    Faculty of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    Environ Microbiol 9:2354-63. 2007
    ..We observed different nifH genes from diverse microbial groups, such as Cyanobacteria, Proteobacteria and methanogenic Archaea...
  101. pmc Genome prediction of PhoB regulated promoters in Sinorhizobium meliloti and twelve proteobacteria
    Ze Chun Yuan
    Center for Environmental Genomics, Department of Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4K1
    Nucleic Acids Res 34:2686-97. 2006
    In proteobacteria, genes whose expression is modulated in response to the external concentration of inorganic phosphate are often regulated by the PhoB protein which binds to a conserved motif (Pho box) within their promoter regions...

Research Grants63

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..cornerstone of this molecular diagnostic platform is a patented pre-enrichment medium called Bartonella Alpha Proteobacteria Growth Medium (BAPGM). Galaxy Diagnostics holds an exclusive license on BAPGM...
  3. Characterization of a novel role for DEAD-box RNA helicases in bacteria.
    ..herein, has profound effects on biofilm formation, motility, and the expression of virulence factors in ?-proteobacteria. The proposed studies detail a plan to investigate the role of DEAD-box RNA helicases in Csr regulation...
  4. Coordination of metabolism and virulence during infection
    Tony Romeo; Fiscal Year: 2013
    ..SirA and CsrA orthologs are highly conserved throughout the gamma-proteobacteria and are important for disease transmission and/or virulence in every species in which they have been examined...
  5. Small Regulatory RNAs of Coxiella burnetii - The Agent of Q Fever
    JAMES MICHAEL BATTISTI; Fiscal Year: 2013
    ..Moreover, the results will clarify the rol of 6S sRNA in g-proteobacteria, where orthologous s factors play distinctive roles in different bacterial species.
  6. Bartonella: dissecting niche-specific adaptation in a human pathogen
    Jane E Koehler; Fiscal Year: 2013
    ..sigma factor gene homologous to the extracytoplasmic function (ECF) sigma factor of several alpha-proteobacteria, is significantly up-regulated at the 28[unreadable]C temperature of the arthropod vector...
  7. Genetic Approaches to Lipid Metabolism
    John E Cronan; Fiscal Year: 2013
    ..coli and this pathway will be dissected. A third pathway to be studied is that found in the a-proteobacteria (e.g., Brucella) which seems a variation of the E. coli pathway...
  8. Host Cell JAK-STAT Activation and Pathogenesis of Spotted Fever Rickettsioses
    Sanjeev K Sahni; Fiscal Year: 2012
    ..conorii are Gram-negative, obligate intracellular a-proteobacteria known to cause Rocky Mountain spotted fever (RMSF) and Mediterranean SF in humans...
  9. Urease Activity and Nitrogen Assimilation in Helicobacter pylori
    ERICA FRANCESCA MILLER; Fiscal Year: 2012
    ..pylori is not typical of other proteobacteria. In fact, H...
  10. Mass Spectrometric Characterization of Lipopolysaccharides
    Jennifer S Brodbelt; Fiscal Year: 2013
    ..forged between the Brodbelt and Trent groups is aimed at elucidating the LPS modification systems of three proteobacteria and elaborating their structure/function relationships...
  11. Regulation of Stationary Phase in Escherichia coli
    Thomas J Silhavy; Fiscal Year: 2013 the master regulator of stationary phase and the general stress response in Escherichia coli and many other proteobacteria. In rapidly growing cells, RpoS is made but it is degraded by the ClpX/P protease...
  12. Evasion of complement-mediated killing by pathogenic rickettsial species
    Juan J Martinez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Gram-negative [unreadable]-proteobacteria of the genus Rickettsia are small (0.3-0.5 x 0.8-1.0 ?m), obligate intracellular organisms...
  13. N-acetylglutamate Synthase: Structure, Function &Defects
    Mendel Tuchman; Fiscal Year: 2012
    ..We found in a number of proteobacteria species (X. campestris, M. maris, O. alexandrii, X. axonopodis, and X...
  14. Integrating lipid biosynthesis with bacterial cell cycle progression
    Sean Murray; Fiscal Year: 2010
    ..Most previous studies on bacterial lipid metabolism have focused on E. coli, a gamma-proteobacteria. Caulobacter in contrast, as an alpha-proteobacteria, is closely related to human pathogenic bacteria, such as ..
  15. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..molecular determinants of helical cell shape and the selective role of shape during host colonization in the Proteobacteria;Csd proteins and CcmA homologues are well conserved among curved to helical Proteobacteria including several ..
  16. Subcellular architecture of regulatory protein complexes at the bacterial pole
    LUCILLE SHAPIRO; Fiscal Year: 2013
    ..Much of the organization in ?-proteobacteria occurs in the cell pole, the anchor not only for the flagellum, but also for the chromosomal origin, the ..
  17. Therapeutic intervention for Brucella
    AMY RAMBOW LARSEN; Fiscal Year: 2009
    ..this goal, we have developed a peptide antibiotic, trifolitoxin (TFX), with activity against members of the ?-proteobacteria, especially Brucella...
  18. Regulation of intestinal barrier by E. coli curli fibrils
    Cagla Tukel; Fiscal Year: 2013
    ..a common component of the biofilms of bacteria, are produced by the members of Bacteriodetes, Firmicutes and Proteobacteria. Recently, we have shown that curli, an amyloid found within the biofilms of enteric bacteria, is recognized ..
  19. Regulation of bacterial manganese metabolism
    MARK R O'BRIAN; Fiscal Year: 2013
    ..coli and other model organisms. B. japonicum belongs to the alpha-Proteobacteria, a diverse taxonomic group that includes numerous members that form close or intracellular associations with ..
  20. Regulatory network of a conserved polar factor in Sinorhizobium meliloti
    JOSEPH CHIUNG CHU CHEN; Fiscal Year: 2013
    ..Results from the investigation will help elucidate regulatory circuits that appear to be iterated in the alpha-proteobacteria group, which includes pathogens such as Brucella and Bartonella...
  21. Regulation of Bacterial Heme Metabolism
    MARK R O'BRIAN; Fiscal Year: 2012
    ..Furthermore, Irr homologs are found in most [unreadable]-Proteobacteria, and thus the proposed work serves as a model for understanding heme and iron metabolism in pathogenic ..
  22. Defining AAA+ enzyme function in bacterial secretion
    ..Interestingly, protein secretion by the type VI secretion system (T6SS) in pathogenic proteobacteria requires CIpV and appears to be tightly controlled by a novel serine-threonine kinase pathway recently ..
  23. Developmental Asymmetry in Agrobacterium tumefaciens
    JASON EUGENE HEINDL; Fiscal Year: 2013
    ..Despite a high degree of conservation among the a-Proteobacteria, including A...
  24. Regulated Assembly of Subcellular Structures in alpha-Proteobacteria
    JOSEPH CHIUNG CHU CHEN; Fiscal Year: 2010
    ..Components of the pathway may serve as targets for new antimicrobial compounds. ..
  25. The mechanism of signal transduction in photoreceptors
    Hartmut Luecke; Fiscal Year: 2006
    ..helix, retinylidene proteins found in phylogenetically diverse microorganisms, including haloarchaea, proteobacteria, cyanobacteria, fungi, and algae...
  26. The Role for NKAP in iNKT cell development
    Virginia Smith Shapiro; Fiscal Year: 2012
    ..In addition to having an important role in the clearance of a subset of alpha-proteobacteria, iNKT cells have also been shown to regulate tumor surveillance and tumor rejection, autoimmune diseases, and ..
  27. Host-microbial interactions in the gut oxygen equilibrium
    Gary D Wu; Fiscal Year: 2013
    ..the well-described "dysbiotic" composition of the gut microbiome observed in IBD, with the bloom of aerobic Proteobacteria and Actinobacteria, is a response of the gut microbiota to higher pO2 levels and subsequent oxidative stress...
    Stephen C Winans; Fiscal Year: 2010
    ..Among these signals, acyl-homoserine lactones (AHLs) are especially widespread among the proteobacteria. AHLs are generally synthesized by proteins resembling the Luxl protein of Vibrio fischeri, and detected by ..
  29. Automated Simultaneous Detection of Bioterrorism Agents
    David Ecker; Fiscal Year: 2005
    ..Bunyaviridae, Flaviviridae, Togaviridae (especially VEE), and Filoviridea families and the alpha, beta, gamma-proteobacteria. To enable deployment at the CDC, the mass spectrometry detector must be developed on an inexpensive and small ..
  30. Intracellular screens discovery of natural products*(RMI)
    Jo Handelsman; Fiscal Year: 2007
    ..We intend to develop expression systems in representatives of four diverse divisions of bacteria: Gamma-Proteobacteria (E...
  31. Quorum Sensing in Burkholderia mallei
    Josephine R Chandler; Fiscal Year: 2010 acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) is common to a variety of Gram-negative Proteobacteria and regulates diverse biological functions...
  32. Early Host Response Elicitation by Agrobacterium
    Marion Brodhagen; Fiscal Year: 2004
    ..mammalian cells, but is not universal, and iii) provide a basis for comparison of host responses to phylogenetically proximal members of the alpha-2 proteobacteria, which include plant symbionts and mammalian pathogens.
  33. Rapid Point-of-Care Diagnostic Test for Chlamydia
    Zihua Wang; Fiscal Year: 2004
    ..Phase I, we propose to develop novel specific TaqMan probes which can differentiate CT from other bacteria or proteobacteria, and develop a rapid real-time PCR for CT detection within 15 minutes on our proprietary lab-in-a-tube ..
  34. International Symposium on the Comparative Biology of the Alpha-Proteobacteria
    Bruno Sobral; Fiscal Year: 2006 applicant): Project Summary: The 2006 International Symposium on the Comparative Biology of the Alpha-Proteobacteria (NIH)...
  35. DNA Replication in B. subtilis
    CHARLES MCHENRY; Fiscal Year: 2006
    ..from Proteobacteria and E. coli, ii. its genome has been sequenced and it has a developed genetic system, iii...
  36. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
    ..The second group consists of all available high G+C a-proteobacteria. The latter genomes are important for understanding nitrogen fixation...
    Samuel Karlin; Fiscal Year: 2001 spacings between repeats, and by properties of repeat families (intergenic, coding, direct, inverted, mixed). ..
    Valley J Stewart; Fiscal Year: 2010
    ..The Nar regulatory network is unique to enterobacteria;other species of proteobacteria (including several human pathogens) contain only the NarQ-NarP system (e.g...
    ROSEMARY RYALL; Fiscal Year: 2008
    ..abstract_text> ..
    David Low; Fiscal Year: 2006
    ..These studies will also provide a detailed framework for understanding epigenetic regulatory mechanisms in other prokaryotes and eukaryotes. ..
  41. Sixth International Conference on Legionella
    Nicholas Cianciotto; Fiscal Year: 2005
    ..This unique gathering of microbiologists, physicians, public health officials, and engineers is the definitive meeting for those concerned with Legionella and its associated diseases. ..
  42. Bacterial flora in normal esophagus & reflux disorders
    Zhiheng Pei; Fiscal Year: 2005
    ..ii) While GERD initially results from chemical damage, bacterial overgrowth may promote intestinal metaplasia of the esophagus. The proposed study allows qualitative and quantitative examination of this hypothesis. ..
  43. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  44. Cryptosporidium parvum DNA replication proteins
    Guan Zhu; Fiscal Year: 2004
    ..The completion of these aims will not only prove or refute our hypothesis, but also establish a new foundation for the drug discovery targeting the parasite unique DNA mechanism machinery. ..
    Floyd Dewhirst; Fiscal Year: 2003
    ..abstract_text> ..
  46. Protein targeting and secretion in Toxoplasma
    Boris Striepen; Fiscal Year: 2004
    ..Mutant analysis will also provide critical information towards the function of the individual secretory organelles involved. ..
    MIKLOS MULLER; Fiscal Year: 2003
    ..b ) Enzymes transferring reducing equivalents from glycolytically reduced NADH and ferredoxin to diverse electron acceptors and O2 will be explored with essentially the same approaches. ..
  48. Support for 2002 GRC on Photosensory Receptors & Signal
    John Spudich; Fiscal Year: 2002
    ..We expect the conference will stimulate exciting discussion of emerging insights, general principles, and the most engaging mysteries on the cutting edge of photosensory signal transduction. ..
  49. Transcriptional Profiles of Escherichia coli Biofilms
    Robert McLean; Fiscal Year: 2002
    ..Overall, this project will explain several fundamental aspects of E. coli biofilm growth and suggest possible targets for future antibiotic research. ..
    William Duax; Fiscal Year: 2006
    ..Proof of the successful prediction of the structures of 20-30 hypothetical members of the SCOR proteome could provide a model for the prediction of protein folding on the basis of as little as 20% sequence homology. ..
  51. Proteomic determination of arsenical action
    Partha Basu; Fiscal Year: 2005
    ..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  53. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  54. IMPDH as a Drug Target in Cryptosporidium
    Boris Striepen; Fiscal Year: 2008
    ..This work will provide urgently needed molecular reagents to understand the biology of nutrient uptake and drug resistance in this unique parasite. [unreadable] [unreadable] [unreadable]..
  55. Ninth International Congress on Toxoplasmosis
    Boris Striepen; Fiscal Year: 2007
    ..gondii that is not often seen in fields as high paced and[unreadable] competitive and has facilitated rapid and sustained progress in research on this pathogen[unreadable] and related parasites. ..
  56. Chemoenzymatic analysis of bryostatin biosynthesis
    Nicole Lopanik; Fiscal Year: 2007
    ..This research may lead to production of bryostatin by a heterologous host. ..
  57. Structure of the Survival Motor Neuron Protein (SMN)
    James Allen; Fiscal Year: 2006
    ..Together, these results should enhance our understanding of the molecular reasons for SMA and potentially lead to new strategies for the development of therapies. ..
  58. Eukaryotic Membrane Protein Folding in E. coli
    John Spudich; Fiscal Year: 2006
    ..Submitted in response to PA-03-100 High Impact/High Risk Research and PA-02-060 Structural Biology of Membrane Proteins. ..
    MATTHEW DEAN; Fiscal Year: 2006
    ..These studies will help uncover the genetic basis of male reproductive fitness in a natural population of house mice. [unreadable] [unreadable]..
  60. Structure-Function of Borrelia Surface Lipoproteins
    WOLFRAM ZUECKERT; Fiscal Year: 2005
    ..Furthermore, they will yield important clues for the design of future intervention strategies. ..
  61. Lipoprotein Transport in Borrelia Spirochetes
    WOLFRAM R ZUECKERT; Fiscal Year: 2010
  62. Butane metabolism in Pseudomonas butanovora
    Daniel Arp; Fiscal Year: 2006
    ..Studies of parallel pathways will be relevant to other metabolic pathways where toxic metabolites are necessarily produced as part of the metabolism of a growth supporting substrate. ..
  63. A Novel Virus that Infects & Sterilizes Insect Vectors of Human Disease
    Drion Boucias; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..