helicobacter pylori

Summary

Summary: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

Articles from Journal RESEARCH

Top Publications

  1. ncbi The primary transcriptome of the major human pathogen Helicobacter pylori
    Cynthia M Sharma
    Max Planck Institute for Infection Biology, RNA Biology Group, D 10117 Berlin, Germany
    Nature 464:250-5. 2010
  2. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
  3. ncbi Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  4. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
  5. pmc Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
    P Malfertheiner
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Gut 56:772-81. 2007
  6. ncbi Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Gut 61:646-64. 2012
  7. ncbi American College of Gastroenterology guideline on the management of Helicobacter pylori infection
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 102:1808-25. 2007
  8. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
  9. ncbi Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
    Lorenzo Fuccio
    University of Bologna, Bologna, Italy
    Ann Intern Med 151:121-8. 2009
  10. pmc Helicobacter pylori in health and disease
    Timothy L Cover
    Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
    Gastroenterology 136:1863-73. 2009

Detail Information

Articles from Journal RESEARCH1

Publications318 found, 100 shown here

  1. ncbi The primary transcriptome of the major human pathogen Helicobacter pylori
    Cynthia M Sharma
    Max Planck Institute for Infection Biology, RNA Biology Group, D 10117 Berlin, Germany
    Nature 464:250-5. 2010
    Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding RNA output...
  2. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
    Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain.
  3. ncbi Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  4. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
    ..We present results applying the new methods to study admixture in African-Americans, recombination in Helicobacter pylori, and drift in populations of Drosophila melanogaster...
  5. pmc Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
    P Malfertheiner
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Gut 56:772-81. 2007
    Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000.
  6. ncbi Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Gut 61:646-64. 2012
    Management of Helicobacter pylori infection is evolving and in this 4th edition of the Maastricht consensus report aspects related to the clinical role of H pylori were looked at again in 2010...
  7. ncbi American College of Gastroenterology guideline on the management of Helicobacter pylori infection
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 102:1808-25. 2007
    b>Helicobacter pylori (H. pylori) remains a prevalent, worldwide, chronic infection. Though the prevalence of this infection appears to be decreasing in many parts of the world, H...
  8. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
    b>Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium...
  9. ncbi Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
    Lorenzo Fuccio
    University of Bologna, Bologna, Italy
    Ann Intern Med 151:121-8. 2009
    b>Helicobacter pylori infection is associated with gastric cancer, but the effect of eradication treatment on gastric cancer risk is not well defined.
  10. pmc Helicobacter pylori in health and disease
    Timothy L Cover
    Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
    Gastroenterology 136:1863-73. 2009
    b>Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H pylori is usually the numerically dominant gastric microorganism...
  11. pmc Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families
    Giovanna Morelli
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Genet 6:e1001036. 2010
    ..We therefore estimated the short-term rates of mutation and recombination in Helicobacter pylori by sequencing an average of 39,300 bp in 78 gene fragments from 97 isolates...
  12. ncbi Worldwide H. pylori antibiotic resistance: a systematic review
    Vincenzo De Francesco
    Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy
    J Gastrointestin Liver Dis 19:409-14. 2010
    ..pylori antibiotic resistance is increasing worldwide, and it is the main factor affecting efficacy of current therapeutic regimens. Our aim was to review recent data on H. pylori resistance towards antibiotics in different countries...
  13. pmc Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    J Clin Invest 121:3088-93. 2011
    ..The increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach, from Western societies...
  14. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..effector proteins to the DC-SIGN signalosome to activate Raf-1, whereas fucose-expressing pathogens such as Helicobacter pylori actively dissociated the KSR1-CNK-Raf-1 complex from the DC-SIGN signalosome...
  15. ncbi Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori
    L Fischbach
    University of North Texas Health Science Center, School of Public Health, Fort Worth, TX 76107, USA
    Aliment Pharmacol Ther 26:343-57. 2007
    Information regarding the effects of drug resistance on therapies for Helicobacter pylori is limited.
  16. ncbi Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial
    Dino Vaira
    University of Bologna, Bologna, Italy
    Ann Intern Med 146:556-63. 2007
    Antimicrobial resistance has decreased eradication rates for Helicobacter pylori infection worldwide.
  17. pmc Helicobacter pylori genome evolution during human infection
    Lynn Kennemann
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 108:5033-8. 2011
    High genetic diversity is a hallmark of the gastric pathogen Helicobacter pylori. We used 454 sequencing technology to perform whole-genome comparisons for five sets of H...
  18. ncbi Helicobacter pylori treatment in the era of increasing antibiotic resistance
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gut 59:1143-53. 2010
    With few exceptions, the most commonly recommended triple Helicobacter pylori regimen (proton pump inhibitor (PPI), amoxicillin and clarithromycin) now provides unacceptably low treatment success...
  19. ncbi Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children
    Luigi Gatta
    Versilia Hospital, Lido di Camaiore, Italy
    Am J Gastroenterol 104:3069-79; quiz 1080. 2009
    Eradication rates with triple therapy (TT) for Helicobacter pylori infection have declined to unacceptable levels. Sequential therapy (ST) is a novel treatment that has shown promise in several controlled trials...
  20. ncbi Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    JAMA 291:187-94. 2004
    Although chronic Helicobacter pylori infection is associated with gastric cancer, the effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is unknown.
  21. ncbi Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy
    J L Tong
    Department of Gastroenterology, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Aliment Pharmacol Ther 25:155-68. 2007
    Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies.
  22. ncbi Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer...
  23. pmc Helicobacter pylori and gastric cancer: factors that modulate disease risk
    Lydia E Wroblewski
    Division of Gastroenterology, Vanderbilt University School of Medicine, 2215 Garland Ave, 1030C MRB IV, Nashville, TN 37232 2279, USA
    Clin Microbiol Rev 23:713-39. 2010
    b>Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H...
  24. ncbi Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial
    Marco Romano
    Dipartimento Medico, AziendaOspedaliera Universitaria, Seconda Universita di Napoli, Napoli, Italy
    Gut 59:1465-70. 2010
    Antimicrobial drug resistance is a major cause of the failure of Helicobacter pylori eradication and is largely responsible for the decline in eradication rate...
  25. ncbi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  26. pmc A new look at anti-Helicobacter pylori therapy
    Seng Kee Chuah
    Division of Gastroenterology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 833 Kaohsiung, Taiwan
    World J Gastroenterol 17:3971-5. 2011
    ..e., 80% or less) in most countries. Therefore, several treatment regimens have emerged to cure Helicobacter pylori (H. pylori) infection. Novel first-line anti-H...
  27. pmc Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface
    Carrie L Shaffer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Pathog 7:e1002237. 2011
    Colonization of the human stomach by Helicobacter pylori is an important risk factor for development of gastric cancer. The H...
  28. pmc Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 140:199-209. 2011
    Chronic infection with the bacterial pathogen Helicobacter pylori causes gastric disorders, ranging from chronic gastritis to gastric adenocarcinoma...
  29. ncbi Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells
    Zhen Liu
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, Chongqing 400038, China
    Microbes Infect 12:854-63. 2010
    b>Helicobacter pylori (H. pylori) is a major human pathogenic bacterium in gastric mucosa. However, the regulatory mechanism of H. pylori-induced immune response is not clear...
  30. pmc Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis
    Nicole Tegtmeyer
    School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Dublin, Ireland
    FEBS J 278:1190-202. 2011
    b>Helicobacter pylori is a very successful human-specific bacterium worldwide. Infections of the stomach with this pathogen can induce pathologies, including chronic gastritis, peptic ulcers and even gastric cancer. Highly virulent H...
  31. pmc Microbial gene identification using interpolated Markov models
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 26:544-8. 1998
    ..In a series of tests on Haemophilus influenzae , Helicobacter pylori and other complete microbial genomes, this system has proven to be very accurate at locating virtually all ..
  32. ncbi Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with ..
  33. pmc An African origin for the intimate association between humans and Helicobacter pylori
    Bodo Linz
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Nature 445:915-8. 2007
    Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H...
  34. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
    Humans have been colonized by Helicobacter pylori for at least 50,000 years and probably throughout their evolution. H. pylori has adapted to humans, colonizing children and persisting throughout life...
  35. ncbi Treatment options for patients with Helicobacter pylori infection resistant to one or more eradication attempts
    F Parente
    L Sacco University Hospital, Via G B Grassi, 74, Milan 20157, Italy
    Dig Liver Dis 35:523-8. 2003
    Proton pump inhibitor-based triple regimens fail to cure Helicobacter pylori infection in at least 10-23% of treated patients. Re-treatment strategies after initial failure remain poorly defined...
  36. ncbi High eradication rates of Helicobacter pylori with a new sequential treatment
    A Zullo
    GI Unit, Nuovo Regina Margherita Hospital, Rome, Italy
    Aliment Pharmacol Ther 17:719-26. 2003
    Eradication rates of Helicobacter pylori with standard triple therapy are disappointing, and studies from several countries confirm this poor performance.
  37. pmc Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    Naomi Ohnishi
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Health Administration Center, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 105:1003-8. 2008
    Infection with cagA-positive Helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma of B cell origin...
  38. ncbi The complete genome sequence of the gastric pathogen Helicobacter pylori
    J F Tomb
    Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 388:539-47. 1997
    b>Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H...
  39. ncbi Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment
    Nadim S Jafri
    University of Louisville, Louisville, Kentucky 40202, USA
    Ann Intern Med 148:923-31. 2008
    Standard proton-pump inhibitor-based therapy for Helicobacter pylori infection fails in up to one quarter of patients. Sequential therapy may be more efficacious.
  40. ncbi Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
    Bin Xiao
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, No 30 Gaotanyan Street, Chongqing, China
    J Infect Dis 200:916-25. 2009
    ..H. pylori is a major human pathogenic bacterium in gastric mucosa. To date, the role of miRNAs in response to H. pylori infection has not been explored...
  41. pmc Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes
    Mikihiko Kawai
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    BMC Microbiol 11:104. 2011
    The genome of Helicobacter pylori, an oncogenic bacterium in the human stomach, rapidly evolves and shows wide geographical divergence. The high incidence of stomach cancer in East Asia might be related to bacterial genotype...
  42. pmc Helicobacter pylori: gastric cancer and beyond
    D Brent Polk
    Department of Pediatrics, University of Southern California, Los Angeles, CA 10027, USA
    Nat Rev Cancer 10:403-14. 2010
    b>Helicobacter pylori is the dominant species of the human gastric microbiome, and colonization causes a persistent inflammatory response. H...
  43. ncbi Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication
    J Molina-Infante
    Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, Spain
    Aliment Pharmacol Ther 31:1077-84. 2010
    b>Helicobacter pylori eradication rates with standard triple therapy have declined to unacceptable levels.
  44. ncbi Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Helicobacter 15:1-20. 2010
    Over the past few years, the profile of Helicobacter pylori infection has changed in Japan. In particular, the relationship between H. pylori and gastric cancer has been demonstrated more clearly...
  45. ncbi Treatment of Helicobacter pylori infection 2011
    Anthony O'Connor
    Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children s Hospital Trinity College Dublin, Dublin, Ireland
    Helicobacter 16:53-8. 2011
    This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H...
  46. ncbi Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial
    Kazutoshi Fukase
    Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Lancet 372:392-7. 2008
    The relation between Helicobacter pylori infection and gastric cancer has been proven in epidemiological studies and animal experiments...
  47. ncbi Oncogenic mechanisms of the Helicobacter pylori CagA protein
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Nat Rev Cancer 4:688-94. 2004
    Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen A (cagA) gene is associated with gastric carcinoma...
  48. ncbi Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report
    P Malfertheiner
    Center for Internal Medicine, Clinic of Gastroenterology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Aliment Pharmacol Ther 16:167-80. 2002
    ..To achieve this, the European Helicobacter Pylori Study Group organized a meeting of specialists and experts from around the world, representatives from ..
  49. pmc Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer
    Wolfgang Fischer
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Pettenkoferstr 9a, D 80336 MUnchen, Germany
    Nucleic Acids Res 38:6089-101. 2010
    ..The human gastric pathogen Helicobacter pylori is known as one of the most genetically diverse species...
  50. ncbi MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    J Immunol 187:3578-86. 2011
    ..In this paper, we have addressed the role of microRNA-155 (miR-155) in the control of Helicobacter pylori infection of the gastrointestinal tract and the development of H...
  51. pmc Birth and death of genes linked to chromosomal inversion
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 108:1501-6. 2011
    ..b>Helicobacter pylori, bacteria in our stomach, are known for their extreme genome plasticity through mutation and recombination ..
  52. ncbi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    The Helicobacter pylori gene cagA and s1 or m1 forms of vacA are more common in disease-associated strains...
  53. pmc The peopling of the Pacific from a bacterial perspective
    Yoshan Moodley
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Chariteplatz 1, 10117 Berlin, Germany
    Science 323:527-30. 2009
    ..These migrations were accompanied by two distinct populations of the specific human pathogen Helicobacter pylori, called hpSahul and hspMaori, respectively. hpSahul split from Asian populations of H...
  54. ncbi Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA
    M Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 27:7047-54. 2008
    ..Chronic infection with Helicobacter pylori is causally associated with gastric carcinoma. H...
  55. ncbi Low eradication rate of Helicobacter pylori with triple 7-14 days and quadriple therapy in Turkey
    Yuksel Gumurdulu
    Baskent Universitesi Tip Fakultesi, Adana Uygulama ve Arastirma Merkezi, Dadaloglu Mahallesi, 39 Sokak, No 6, 01250 Adana, Turkey
    World J Gastroenterol 10:668-71. 2004
    The eradication rate of Helicobacter pylori (H pylori) shows variation among countries and regimens of treatment...
  56. ncbi Gastric cancer: epidemiology and risk factors
    Guenter J Krejs
    Department of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria
    Dig Dis 28:600-3. 2010
    ..Recognized risk factors for gastric cancer are infection with Helicobacter pylori, dietary factors (e.g...
  57. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
    ..A prime example is Helicobacter pylori, which infects 50% of the world's population and is now known to be responsible for inducing chronic ..
  58. pmc Comparison of Helicobacter pylori virulence gene expression in vitro and in the Rhesus macaque
    Jenni K Boonjakuakul
    Department of Medicine, Division of Infectious Disease, 513 Parnassus Avenue, HSE 418 Box 0654, University of California, San Francisco, San Francisco, CA 94143, USA
    Infect Immun 73:4895-904. 2005
    ..real-time reverse transcriptase PCR assay to measure the transcript abundance of 46 known and putative Helicobacter pylori virulence genes, including 24 genes on the Cag pathogenicity island. The expression profile of H...
  59. ncbi Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice
    Yun Shi
    Department of Clinical Microbiology and Immunology, Third Military Medical University, Chongqing 400038, China
    J Immunol 184:5121-9. 2010
    CD4(+) T cell responses are critical for the pathogenesis of Helicobacter pylori infection. The present study evaluated the role of the Th17 subset in H. pylori infection. H...
  60. ncbi Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells
    Maria Kaparakis
    Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
    Cell Microbiol 12:372-85. 2010
    ..We purified OMVs from the Gram-negative mucosal pathogens: Helicobacter pylori, Pseudomonas aeruginosa and Neisseria gonorrhoea and demonstrated that these peptidoglycan containing OMVs ..
  61. ncbi Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature
    Elena Lionetti
    Department of Paediatrics, University of Catania, Catania, Italy
    Helicobacter 15:79-87. 2010
    The current guidelines suggest the use of triple therapy as first choice treatment of Helicobacter pylori infection, although the eradication failure rate is more than 30%. Current interest in probiotics as therapeutic agents against H...
  62. pmc Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA
    Kelly A Gangwer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Bacteriol 192:6126-35. 2010
    b>Helicobacter pylori is a genetically diverse organism that is adapted for colonization of the human stomach. All strains contain a gene encoding a secreted, pore-forming toxin known as VacA...
  63. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
    Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop gastric cancer. The H...
  64. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
    To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases.
  65. ncbi Treatment of Helicobacter pylori
    Michael Selgrad
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Germany
    Curr Opin Gastroenterol 27:565-70. 2011
    The article will give an overview on reasons for treatment failure and tries to show new concepts for Helicobacter pylori treatment.
  66. ncbi Role of type IV secretion in Helicobacter pylori pathogenesis
    Steffen Backert
    Otto von Guericke Universitat Magdeburg, Institut fur Medizinische Mikrobiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cell Microbiol 10:1573-81. 2008
    b>Helicobacter pylori is a highly successful human-specific gastric pathogen that colonizes more than half the world's population...
  67. pmc Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion
    Benjamin Hoy
    Junior Research Group, Paul Ehrlich Institute, Langen, Germany
    EMBO Rep 11:798-804. 2010
    ..Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin...
  68. ncbi c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    Markus Stein
    IRIS Chiron S p A, Via Fiorentina 1, 53100 Siena, Italy
    Mol Microbiol 43:971-80. 2002
    The human pathogen Helicobacter pylori colonizes the mucous layer of the stomach. During parasitic infection, freely swimming bacteria adhere to the gastric epithelial cells and trigger intracellular signalling pathways...
  69. pmc Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection
    B Schmausser
    Institut fur Pathologie, Universitat Wurzburg, Wuerzburg, Germany
    Clin Exp Immunol 136:521-6. 2004
    ..TLR4, TLR5 and TLR9 have been microanatomically localized in patients with noninflamed gastric mucosa and Helicobacter pylori gastritis by immunohistochemistry...
  70. pmc A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island
    Patrick Olbermann
    Institute for Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 6:e1001069. 2010
    The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI-carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H...
  71. ncbi Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation
    Ramazan Gen
    Department of Endocrinology and Metabolism, Region Education and Research Hospital, Erzurum, Turkey
    South Med J 103:190-6. 2010
    Many studies have revealed a close relationship between Helicobacter pylori (HP) infection and insulin resistance...
  72. ncbi Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis
    Junichi Kawashima
    Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda Tsujido Machi, Kawagoe, Saitama 350 8550, Japan
    J Gastroenterol 44:1046-54. 2009
    We attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection.
  73. ncbi The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis
    Steffen Backert
    University College Dublin, Ireland
    Helicobacter 15:163-76. 2010
    ..One of the key examples is the Helicobacter pylori CagA effector protein which is translocated by a type-IV secretion system...
  74. ncbi Regulatory circuits in Helicobacter pylori : network motifs and regulators involved in metal-dependent responses
    Alberto Danielli
    Department of Biology, University of Bologna, Bologna, Italy
    FEMS Microbiol Rev 34:738-52. 2010
    The ability of Helicobacter pylori, one of the most successful human bacterial pathogens, to colonize the acidic gastric niche persistently, depends on the proper homeostasis of intracellular metal ions, needed as cofactors of essential ..
  75. pmc Helicobacter pylori from Peruvian amerindians: traces of human migrations in strains from remote Amazon, and genome sequence of an Amerind strain
    Dangeruta Kersulyte
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 5:e15076. 2010
    The gastric pathogen Helicobacter pylori is extraordinary in its genetic diversity, the differences between strains from well-separated human populations, and the range of diseases that infection promotes.
  76. pmc Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells
    Salim Ismail
    Department of Surgery, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Infect Immun 71:5670-5. 2003
    b>Helicobacter pylori infection, which is always associated with gastritis, can progress to ulceration or malignancy. The diversity in clinical outcomes is partly attributed to the expression of virulence factors and adhesins by H. pylori...
  77. ncbi Helicobacter pylori and autoimmune pancreatitis: role of carbonic anhydrase via molecular mimicry?
    F Guarneri
    Istituto di Dermatologia, Policlinico Gaetano Martino, Universita di Messina, Messina, Italy
    J Cell Mol Med 9:741-4. 2005
    ..A link between gastric infection by Helicobacter pylori and autoimmune pancreatitis has been hypothesized...
  78. ncbi Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    Matthias Selbach
    Max Planck Institut für Infektionsbiologie, Abt Molekulare Biologie, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Biol Chem 277:6775-8. 2002
    The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells...
  79. pmc Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease
    Mike Tsz Hin Ng
    Division of Applied Medicine, Aberdeen University, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Infect Immun 78:1345-52. 2010
    Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H...
  80. pmc Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche
    Shumin Tan
    Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA
    PLoS Pathog 5:e1000407. 2009
    b>Helicobacter pylori (Hp) intimately interacts with the gastric epithelial surface and translocates the virulence factor CagA into host cells in a contact-dependent manner...
  81. ncbi Polymorphisms in Toll-like receptor genes and risk of cancer
    E M El-Omar
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
    Oncogene 27:244-52. 2008
    ..A classic example of this paradigm is the Helicobacter pylori-induced gastric cancer model...
  82. ncbi Molecular hydrogen as an energy source for Helicobacter pylori
    Jonathan W Olson
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Science 298:1788-90. 2002
    The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as a respiratory substrate when grown in the laboratory...
  83. ncbi Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus
    Wolfgang Fischer
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munchen, Germany
    FEBS J 278:1203-12. 2011
    ..One example is the human pathogen Helicobacter pylori, which uses the Cag-T4SS to induce a pro-inflammatory response and multiple cytoskeletal and gene ..
  84. ncbi Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?
    Henry J Windle
    School of Medicine, Trinity College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland
    Pediatrics 119:e754-9. 2007
    We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment...
  85. ncbi Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population
    Toshiaki Gunji
    Center for Preventive Medicine, Kanto Medical Canter, NTT East, Tokyo, Japan
    Am J Gastroenterol 103:3005-10. 2008
    Metabolic syndrome comprises a cluster of metabolic abnormalities leading to insulin resistance and atherosclerosis, and Helicobacter pylori is thought to be a contributing factor.
  86. pmc Role of innate immunity in Helicobacter pylori-induced gastric malignancy
    Richard M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232 2279, USA
    Physiol Rev 90:831-58. 2010
    b>Helicobacter pylori colonizes the majority of persons worldwide, and the ensuing gastric inflammatory response is the strongest singular risk factor for peptic ulceration and gastric cancer...
  87. ncbi Helicobacter pylori infection generates genetic instability in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, University of Roskilde, Denmark
    Biochim Biophys Acta 1806:58-65. 2010
    The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis...
  88. ncbi High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 137:525-31. 2009
    The long-term prognosis of peptic ulcers associated with neither Helicobacter pylori nor nonsteroidal anti-inflammatory drugs (NSAIDs) is unknown.
  89. ncbi Pathogenesis of Helicobacter pylori infection
    Ana C Costa
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Helicobacter 14:15-20. 2009
    b>Helicobacter pylori induces chronic inflammation of the gastric mucosa, but only a proportion of infected individuals develop peptic ulcer disease or gastric carcinoma...
  90. pmc From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
    Jean Michel Thiberge
    Institut Pasteur, Unité postulante de Pathogenèse de Helicobacter, Paris, France
    BMC Genomics 11:368. 2010
    b>Helicobacter pylori infection is associated with several gastro-duodenal inflammatory diseases of various levels of severity...
  91. ncbi Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children
    Lucia Pacifico
    Department of Pediatrics, La Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Eur J Endocrinol 158:323-32. 2008
    b>Helicobacter pylori, and the chronic gastric inflammation that it causes, may compromise the function and survival of ghrelin-producing cells, resulting in a decrease of circulating ghrelin levels...
  92. pmc A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation
    Nicole Tegtmeyer
    University College Dublin, School of Biomolecular and Biomedical Sciences, Ardmore House, Belfield Campus, Dublin 4, Ireland
    J Biol Chem 285:23515-26. 2010
    ..Here, we demonstrate that CagL, a 26-kDa protein of the gastric pathogen and type I carcinogen Helicobacter pylori, mimics fibronectin in various cellular functions...
  93. ncbi Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in South African patients with upper gastrointestinal diseases
    Nicoline F Tanih
    Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X 1314, Alice 5700, South Africa
    Acta Trop 116:68-73. 2010
    Clinical response to Helicobacter pylori infection may be determined by specific virulence-associated genotypes which varies geographically. The aim of this study was to investigate the diversity of putative virulence markers of H...
  94. ncbi The response of Asian patients with functional dyspepsia to eradication of Helicobacter pylori infection
    Kok Ann Gwee
    Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Eur J Gastroenterol Hepatol 21:417-24. 2009
    The role of Helicobacter pylori infection in functional dyspepsia (FD) remains controversial. Several randomized controlled trials involving populations in the West, observed no statistically significant advantage over placebo...
  95. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    There is continuing interest in identifying Helicobacter pylori virulence factors that might predict the risk for symptomatic clinical outcomes...
  96. pmc Helicobacter pylori detection and antimicrobial susceptibility testing
    Francis Megraud
    INSERM U853, and Université Victor Segalen Bordeaux 2, and Laboratoire de Bacteriologie, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Clin Microbiol Rev 20:280-322. 2007
    The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases...
  97. pmc NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    Sabine Brandt
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 102:9300-5. 2005
    The Helicobacter pylori immunodominant protein, CagA, is associated with severe gastritis and carcinoma. Injection of CagA into gastric epithelial cells by type IV secretion leads to actin-cytoskeletal rearrangements and cell scattering...
  98. ncbi Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue
    S Odenbreit
    Max Planck Institut fur Biologie, Abteilung Infektionsbiologie, Tubingen, Germany
    Mol Microbiol 31:1537-48. 1999
    In this study, we isolated and characterized a chromosomal locus of Helicobacter pylori previously identified by transposon shuttle mutagenesis as being involved in the adhesion of the pathogen to gastric epithelial cells...
  99. ncbi Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol
    Hubert Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria
    Am J Cardiol 93:219-20. 2004
    We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0...
  100. ncbi Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Medical School, Japan
    Dig Dis Sci 47:1582-9. 2002
    ..In conclusion, rebamipide may prevent the delay of acetic acid-induced gastric ulcer healing caused by H. pylori through modulating cell kinetics and inhibiting neutrophil infiltration...
  101. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    b>Helicobacter pylori infection increases gastric regulatory T cell (Treg) response, which may contribute to H pylori immune escape...

Research Grants75

  1. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..We will focus our efforts on in-depth studies of 3 major gram negative bacterial human pathogens including Helicobacter pylori, Salmonella enterica serovar Typhi and Shigella, each primarily affecting a distinct major segment of the ..
  2. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..and other entero-pathogens such as Yersinia sp., Vibrio cholerae, Campylobacter jejuni, Helicobacter pylori, Listeria monocytogenes, Clostridium perfringens and C. difficile...
  3. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The acquisition of Helicobacter pylori and its clinical sequelae of peptic ulcer disease and gastric cancer remain substantial health concerns for our Veterans. H...
  4. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    b>Helicobacter pylori (Hp) infection is the major cause of gastric inflammation, peptic ulcer disease, and gastric cancer...
  5. Molecular Mechanisms of Gastrin Mediated Pathways in Gastric Cancer Cells
    Basabi Rana; Fiscal Year: 2013
    ..an increase in serum gastrin levels is a common side effect of the use of proton pump inhibitors (PPIs) or Helicobacter pylori infection...
  6. THE ROLE OF CELL SHAPE AND CELL WALL IN HELICOBACTER PYLORI PATHOGENESIS
    NINA REDA SALAMA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Evident in its name, Helicobacter pylori is a helical bacterium that colonizes the human stomach causing clinical outcomes ranging from mild gastritis to peptic ulcer and gastric cancer...
  7. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    PROJECT SUMMARY (ABSTRACT) Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa of humans. Although most H...
  8. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..rodentium. However, eotaxin-1 is not increased in mouse Helicobacter pylori-induced gastritis tissues, indicating that this is not a non specific component of inflammation...
  9. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..that include but not limited to Yersinia pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani...
  10. Compounds to treat Helicobacter pylori infection
    Kenneth Coleman; Fiscal Year: 2013
    ..provided by applicant): The goal of this project is to discover lead compounds acting specifically against Helicobacter pylori, the causative agent of peptic ulcer and gastric carcinoma...
  11. Acid Adaptation Targets for Eradication of Helicobacter pylori
    George Sachs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Helicobacter pylori infects the stomach of half of the world's population. This infection is a primary cause of peptic ulcer disease and a high risk factor for gastric cancer...
  12. Effect of Helicobacter pylori cell shape on pathogenesis
    LAURA ELIZABETH MARTINEZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Helicobacter pylori is a Gram-negative helical rod-shaped bacterium that infects the stomach of 50% of all humans. H...
  13. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The gastric carcinogen Helicobacter pylori induces superficial gastritis and transient hypochlorhydria which may progress to atrophic gastritis and eventually gastric adenocarcinoma...
  14. DNA recombinational repair in Helicobacter pylori
    Ge Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori infects the stomachs of approximately 50% of humans and results in a series of human gastric diseases...
  15. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), several nutrition-related pathways (one carbon ..
  16. Control of bacterial morphology and differentiation
    Yves V Brun; Fiscal Year: 2013
    ..coli subverts innate defenses during the infection process, and the helical shape of Helicobacter pylori is important for colonization of the stomach...
  17. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
    ..depends on a complex equilibrium between inflammation resulting from gastric bacterial flora (especially Helicobacter pylori), and intake of carcinogenic and protective nutrients. H...
  18. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  19. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..cancer evolves in the stomach in the setting of chronic atrophic gastritis usually in association with Helicobacter pylori infection. While the role of H...
  20. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori is a type I carcinogen and infection with this pathogenic bacterium is considered the leading cause of gastric cancer worldwide. Infection by H...
  21. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori (Hp) infects the gastric mucosa of >50% of the world's population...
  22. Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pylori
    MARION SHONN DORER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori is a major public health problem: at least 50% of the world population is persistently infected with this bacterium, including at least 30% of the United States population [1]...
  23. Prevalence of environmental and genetic risk factors for gastric cancer in a popu
    LOVELL ALLAN JONES; Fiscal Year: 2011
    ..The etiologic factors for GC include Helicobacter Pylori infection, dietary factors and genetic susceptibility...
  24. Narrow-spectrum Agents Acting against Helicobacter pylori
    Kenneth Coleman; Fiscal Year: 2013
    ..provided by applicant): The goal of this project is to develop a therapeutic acting specifically against Helicobacter pylori, the causative agent of peptic ulcer and gastric carcinoma...
  25. 16th international conference on Campylobacter, Helicobacter and related organism
    Irving Nachamkin; Fiscal Year: 2011
    ..At the 2nd workshop in Brussels in 1983, Helicobacter pylori (then named Campylobacter pylori) was introduced to the world and the microbiological revolution of ..
  26. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..This lead compound cannot kill Staphylococcus aureus, Streptococcus pneumoniae, Helicobacter pylori or Haemophilus ducreyi, among other strains, in vitro...
  27. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  28. Microbiomes in Human Pancreatic Cancer
    Dominique S Michaud; Fiscal Year: 2013
    ..Epidemiologic studies suggest that Helicobacter pylori infection and periodontal disease increase the risk of pancreatic cancer...
  29. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..Human pathogens such as HIV-1, Mycobacterium tuberculosis, Helicobacter pylori and Porphyromonas gingivalis are able to infect DCs and disrupt DC maturation, leading to immunosuppression...
  30. In vivo observations of transcription at single-nucleotide resolution
    MATTHEW HERBERT LARSON; Fiscal Year: 2013
    ..will provide insight into the proliferation of pathogenic bacteria linked with carcinogenesis, such as Helicobacter pylori (H. pylori) and Chlamydia trachomatis (C...
  31. Immune Evasion by H. pylori
    Victor E Reyes; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Our goal is to define how Helicobacter pylori (Hp) impairs the host's immune response to establish a lifelong infection. Hp infects the gastric mucosa of >50% of the world's population...
  32. Mechanism of H. pylori-induced risk reduction for inflammatory bowel disease
    Jay Luther; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Helicobacter pylori infection is widely prevalent as more than half of the world's population is colonized with this organism. H...
  33. Genetic requirements of Helicobacter pylori infection
    NINA REDA SALAMA; Fiscal Year: 2013
    PROJECT SUMMARY / ABSTRACT Helicobacter pylori chronically infect the human stomach of 50% of the population worldwide. Ten to 30% of those infected will present with severe disease including peptic ulcers and gastric cancers15. H...
  34. Anti-inflammatory actions of bone morphogenetic protein signaling in the stomach
    Andrea Todisco; Fiscal Year: 2013
    ..In a series of preliminary studies we observed that inflammatory stimuli such as Helicobacter pylori (Hp) and INF-3 induce the expression of BMP-4 both in vivo and in vitro, supporting the notion that BMP-4 ..
  35. Mucosal Adjuvants Targeting Dendritic Cells
    John G Nedrud; Fiscal Year: 2010
    ..and two different classes of pathogens: a respiratory virus, Sendai virus and the gastric pathogen, Helicobacter pylori. These studies may lead both to an enhanced understanding of the role of subsets of dendritic cells in ..
  36. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2013
    ..have recently discovered that SMO is induced in several epithelial cell typesby multiple stimuli including Helicobacter pylori infection, exposure to Enterotoxigenic Bacteroides fragilis (ETBF), and exposure to the general mediators ..
  37. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2013
    ..However, our understanding of gastric cancer underwent a dramatic change with the discovery of Helicobacter pylori in 1982 by Marshall and Warren, who in 2005 were awarded the Nobel Prize in Physiology or Medicine...
  38. Urease Activity and Nitrogen Assimilation in Helicobacter pylori
    ERICA FRANCESCA MILLER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Discovered in the early 1980's, Helicobacter pylori is a common cause of peptic and duodenal ulcers, gastritis, anemia, and certain gastric cancers...
  39. Case Control Study of Pancreas Cancer in Shanghai, China
    Harvey A Risch; Fiscal Year: 2012
    ..in China (and gastric cancer more frequent), yet risk factors for these cancers?gastric colonization by Helicobacter pylori, cigarette smoking, nitrite or A/-nitrosamine intake?are more prevalent in China...
  40. H. pylori ancestral haplotype a gastric cancer risk determinant in Latin America
    Douglas Morgan; Fiscal Year: 2013
    ..b>Helicobacter pylori (Hp) is the dominant risk factor for gastric cancer...
  41. Mass Spectrometric Characterization of Lipopolysaccharides
    Jennifer S Brodbelt; Fiscal Year: 2013
    ..b>Helicobacter pylori is now recognized as the primary cause of peptic ulcer disease and gastric cancer, Camphorbacter jejuni and ..
  42. PPK Dependent Acidocalcisome-like Granules, Polyphosphates and Helicobacter
    Manfredo J Seufferheld; Fiscal Year: 2010
    ..at the University of Illinois at Urbana-Champaign proposes studies to explore the overall hypothesis that Helicobacter pylori acidocalcisome-like granule (ALGs) are polyphosphate-rich organelles...
  43. Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
    Meira Epplein; Fiscal Year: 2013
    ..Infection with Helicobacter pylori, the strongest known risk factor for gastric cancer, is also endemic throughout East Asia, but only a small ..
  44. Pathways and pathogens affecting gastric epithelial repair in vivo
    Marshall H Montrose; Fiscal Year: 2013
    ..in the US healthcare system and worldwide, caused in large part by the presence of the gastric pathogen Helicobacter pylori or the upper GI toxicity of ingested therapeutic drugs...
  45. The Structure and Function of the Bacterial Chemosome
    Brian R Crane; Fiscal Year: 2013
    ..Importantly, many human pathogens such Vibrio cholerae, Helicobacter pylori, and Borrelia burgdorferi (Lyme disease) rely on chemotaxis to establish infection...
  46. Parameters Involved in Metal Recognition
    Michael J Maroney; Fiscal Year: 2013
    ..coli and Helicobacter pylori. The approach involves cloning and expressing trafficking proteins, characterizing their metal ion ..
  47. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..We recently used the rhesus macaque model to demonstrate that, like in humans, BD2 expression is induced by Helicobacter pylori, a common gastric pathogen that is the causative agent of peptic ulcer and increases the risk for gastric ..
  48. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2012
    ..provided by applicant): The aims are to investigate the gastric physiology of the gastric pathogen Helicobacter pylori. Specific Aims: (A). Identify the acid response regulon and signaling system of the cytoplasmic pH sensor...
  49. Novel Antibacterial Drugs Targeting DNA Repair Enzymes
    Gerald R Smith; Fiscal Year: 2010
    ..We will use this same approach to look for inhibitors of AddAB from the important gastric pathogen Helicobacter pylori. We have shown that addAB deletion mutants have impaired colonization ability;thus, inhibiting AddAB ..
  50. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan L Thibeault; Fiscal Year: 2013
    ..quantification of total eubacterial load and the presence and location of specific species, including helicobacter pylori, within the laryngeal mucosa and lamina propria and 3) to use an in vitro model system to determine the ..
  51. Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori
    Markus Stein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori Gastritis and gastric carcinoma, the second leading cause of cancer-related deaths in the world, have been linked to ..
  52. Disappearing gastrointestinal microbiota in epidemic obesity.
    Martin J Blaser; Fiscal Year: 2013
    ..We will test this hypothesis by studying both the colonic microbiota, and Helicobacter pylori, the dominant gastric bacteria that interact with gastric epithelium, which produces hormones (leptin and ..
  53. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Helicobacter pylori is a helical rod shaped bacterium that colonizes the human stomach causing clinical outcomes that range from mild gastritis to peptic ulcer and gastric cancers...
  54. The role of Plasminogen activator Inhibitor-1 in Helicobacter pylori infection.
    Sarah E Keates; Fiscal Year: 2010
    ..examines the hypothesis that infection of gastric epithelial cells (GEC's) with the bacterial pathogen Helicobacter pylori causes an upregulation of Plasminogen activator inhibitor-1 (PAI-1), which contributes to gastric cancer ..
  55. Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori Infection
    Liangfang Zhang; Fiscal Year: 2013
    ..oils) with an innovative nano-delivery technology to develop a new nanotherapeutic for eradicating Helicobacter pylori (H. pylori) infection burden...
  56. A New Antibacterial Drug Target: Analyzing Inhibitor Binding to a Bacterial Metal
    Richard C Holz; Fiscal Year: 2010
    ..5.1.18), is lethal to Helicobacter pylori and Mycobacterium smegmatis. Even in the presence of lysine supplemented media H. pylori was unable to grow...
  57. Clinical Development of SQ109 for H. pylori Infection
    LISA BETH FERSTENBERG; Fiscal Year: 2013
    ..is to develop and implement a small pilot study to validate the potential of SQ109 for treatment of Helicobacter pylori infections...
  58. Bacterial Surface Structures of Helicobacter Pylori and Campylobacter Jejuni
    MICHAEL STEPHEN TRENT; Fiscal Year: 2013
    ..objective of this proposal is to unravel the molecular mechanisms by which two pathogenic organisms, Helicobacter pylori and Campylobacter jejuni, modify their LPS structure and the role these modifications play in virulence...
  59. Role of Helicobacter Pylori in the Pathogenesis of Childhood Asthma
    Jay V Solnick; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Helicobacter pylori commonly infects the human stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. The prevalence of H...
  60. Helicobacter pylori subtypes, inflammation, and gastric cancer risk
    Meira Epplein; Fiscal Year: 2013
    ..The specific project proposed in this award, focusing on Helicobacter pylori, host inflammatory cytokines, and gastric cancer risk, will serve as a training opportunity so that Dr...
  61. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona-Santos; Fiscal Year: 2011
    ..deaths in Latin America, is associated with the high prevalence of infection with the type I carcinogen Helicobacter pylori. Several immunological events are associated with the inflammatory response in the stomach of infected ..
  62. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..expression will provide new molecular targets for therapy to reduce the large medical burden imposed by Helicobacter pylori, which chronically colonizes over half of the world's human population and causes gastritis, ulcer ..
  63. NF-kB Signaling and H. Pylori-induced Gastric Disease
    Lin Feng Chen; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Helicobacter pylori is one of the most wide-spread infections in humans worldwide and H...
  64. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Helicobacter pylori (H. pylori) bacteria play a significant role in the etiology of gastric and duodenal ulcers, gastro-esophageal reflux disease and gastric adenocarcinoma...
  65. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    ..The overall HYPOTHESES TO BE TESTED are that 1) eradication of Helicobacter pylori (H...
  66. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population...
  67. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
    b>Helicobacter pylori (HP infection has been identified as risk factor adenocarcinoma of the distal stomach...
  68. Transcriptional Control of the Helicobacter pylori RpoN Regulon
    TIMOTHY RANDALL HOOVER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori is the causative agent of peptic ulcer disease and a variety of other diseases in humans, including gastric cancer and mucosal-associated lymphoma. Motility is required for H...
  69. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    b>Helicobacter pylori is a major human pathogen that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
  70. Developing an inactivated whole cell H. pylori vaccine
    GARY NABORS; Fiscal Year: 2006
    Currently there exists no vaccine for the prevention of infection with the ubiquitous gastric pathogen Helicobacter pylori, and drug therapy for the infection is complicated by poor patient compliance, the high cost of treatment, and ..
  71. T Cell Initiated Gastric Pathology
    ROBINNA LORENZ; Fiscal Year: 2007
    The bacteria Helicobacter pylori is a major pathogen which, in addition to infecting over half of the world's population, is linked to gastric and duodenal ulcer disease, mucosal-associated lymphomas, and adenocarcinoma...
  72. HOST RESPONSE TO HELICOBACTER PYLORI INFECTION
    Pelayo Correa; Fiscal Year: 2000
    Gastritis due to Helicobacter Pylori is the most common chronic infection in the world today. It has been classified by IARC (WHO) as a Class I human carcinogen...
  73. DRUG RESISTANCE AND GENE TRANSFER IN H PYLORI
    Douglas Berg; Fiscal Year: 2003
    b>Helicobacter pylori (HP) is a major cause of peptic ulcer disease and an early risk factor for gastric cancer...
  74. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    b>Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some...
  75. H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES
    Douglas Berg; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): Helicobacter pylori (Hp), one of the most genetically diverse of bacterial species, chronically infects the gastric mucosa of more than half of all persons world wide...