vibrio vulnificus

Summary

Summary: A species of halophilic bacteria in the genus VIBRIO, which lives in warm SEAWATER. It can cause infections in those who eat raw contaminated seafood or have open wounds exposed to seawater.

Top Publications

  1. pmc Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery
    Hyun Uk Kim
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
    Mol Syst Biol 7:460. 2011
  2. pmc Regulation of cytotoxicity by quorum-sensing signaling in Vibrio vulnificus is mediated by SmcR, a repressor of hlyU
    Chung Ping Shao
    Department of Nursing, National Tainan Institute of Nursing, Tainan 700, Taiwan, Republic of China
    J Bacteriol 193:2557-65. 2011
  3. pmc A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity
    Shee Eun Lee
    National Research Laboratory of Molecular Microbial Pathogenesis and Department of Microbiology, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Gwangju 501 746, South Korea
    Infect Immun 74:694-702. 2006
  4. pmc Prey bacteria shape the community structure of their predators
    Huan Chen
    Environmental Sciences Institute, Florida A and M University, 1515 S Martin Luther King, Jr Blvd, Tallahassee, FL 32307, USA
    ISME J 5:1314-22. 2011
  5. pmc Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus
    Francisco J Roig
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Valencia, Valencia, Spain
    Appl Environ Microbiol 77:657-68. 2011
  6. pmc Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection
    Jayme S Kwak
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:1645-50. 2011
  7. pmc SOLiD sequencing of four Vibrio vulnificus genomes enables comparative genomic analysis and identification of candidate clade-specific virulence genes
    Paul A Gulig
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA
    BMC Genomics 11:512. 2010
  8. ncbi Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
  9. ncbi Increasing rates of vibriosis in the United States, 1996-2010: review of surveillance data from 2 systems
    Anna Newton
    Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Clin Infect Dis 54:S391-5. 2012
  10. ncbi Antibiotic activity of lectins from marine algae against marine vibrios
    W R Liao
    Transworld Institute of Technology, Touliu, Yunlin, 640, Taiwan
    J Ind Microbiol Biotechnol 30:433-9. 2003

Detail Information

Publications291 found, 100 shown here

  1. pmc Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery
    Hyun Uk Kim
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
    Mol Syst Biol 7:460. 2011
    ..genomic information for drug targeting and discovery, and apply this approach to the opportunistic pathogen Vibrio vulnificus CMCP6. First, we partially re-sequenced and fully re-annotated the V...
  2. pmc Regulation of cytotoxicity by quorum-sensing signaling in Vibrio vulnificus is mediated by SmcR, a repressor of hlyU
    Chung Ping Shao
    Department of Nursing, National Tainan Institute of Nursing, Tainan 700, Taiwan, Republic of China
    J Bacteriol 193:2557-65. 2011
    Cytotoxicity is an important virulence determinant in the pathogenesis of Vibrio vulnificus, and two cytotoxins, RTX (encoded by rtxA1) and cytolysin/hemolysin (encoded by vvhA), have been identified in this organism...
  3. pmc A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity
    Shee Eun Lee
    National Research Laboratory of Molecular Microbial Pathogenesis and Department of Microbiology, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Gwangju 501 746, South Korea
    Infect Immun 74:694-702. 2006
    ..In this study, we show the highly potent mucosal adjuvant activity of a Vibrio vulnificus major flagellin (FlaB)...
  4. pmc Prey bacteria shape the community structure of their predators
    Huan Chen
    Environmental Sciences Institute, Florida A and M University, 1515 S Martin Luther King, Jr Blvd, Tallahassee, FL 32307, USA
    ISME J 5:1314-22. 2011
    ..Bacteriovorax, a predator within the group of BALOs, in environmental waters were fed two prey bacteria, Vibrio vulnificus and Vibrio parahaemolyticus...
  5. pmc Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus
    Francisco J Roig
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Valencia, Valencia, Spain
    Appl Environ Microbiol 77:657-68. 2011
    ..multifunctional autoprocessing repeats-in-toxin (MARTX) toxin domain organization within the aquatic species Vibrio vulnificus as well as to study the evolution of the rtxA1 gene...
  6. pmc Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection
    Jayme S Kwak
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:1645-50. 2011
    b>Vibrio vulnificus is a food-borne bacterial pathogen associated with 1% of all food-related deaths, predominantly because of consumption of contaminated seafood. The ability of V...
  7. pmc SOLiD sequencing of four Vibrio vulnificus genomes enables comparative genomic analysis and identification of candidate clade-specific virulence genes
    Paul A Gulig
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA
    BMC Genomics 11:512. 2010
    b>Vibrio vulnificus is the leading cause of reported death from consumption of seafood in the United States...
  8. ncbi Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling
    Claudia Toma
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa
    J Immunol 184:5287-97. 2010
    b>Vibrio vulnificus and Vibrio cholerae are Gram-negative pathogens that cause serious infectious disease in humans...
  9. ncbi Increasing rates of vibriosis in the United States, 1996-2010: review of surveillance data from 2 systems
    Anna Newton
    Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Clin Infect Dis 54:S391-5. 2012
    ..COVIS conducts passive surveillance and FoodNet conducts active surveillance for laboratory-confirmed Vibrio infections...
  10. ncbi Antibiotic activity of lectins from marine algae against marine vibrios
    W R Liao
    Transworld Institute of Technology, Touliu, Yunlin, 640, Taiwan
    J Ind Microbiol Biotechnol 30:433-9. 2003
    ....
  11. ncbi The cytotoxin-hemolysin genes of human and eel pathogenic Vibrio vulnificus strains: comparison of nucleotide sequences and application to the genetic grouping
    Mitsutoshi Senoh
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Japan
    Microbiol Immunol 49:513-9. 2005
    b>Vibrio vulnificus can be divided into two groups on the basis of pathogenesis. Group 1 is pathogenic only to humans, whereas group 2 is pathogenic to eels and occasionally to humans...
  12. pmc Identification of genetic loci required for capsular expression in Vibrio vulnificus
    Amy B Smith
    Louisiana State University, Department of Biological Sciences, Baton Rouge, Louisiana, USA
    Infect Immun 71:1091-7. 2003
    Transposon mutagenesis of an encapsulated, virulent strain of Vibrio vulnificus 1003(O) led to the identification of four genetic regions that are essential to capsular polysaccharide (CPS) expression and virulence...
  13. pmc Population structures of two genotypes of Vibrio vulnificus in oysters (Crassostrea virginica) and seawater
    Elizabeth Warner
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 74:80-5. 2008
    b>Vibrio vulnificus biotype 1 strains can be classified into two genotypes based on the PCR analysis of variations in the virulence-correlated gene (vcg)...
  14. ncbi High numbers of Vibrio vulnificus in tar balls collected from oiled areas of the north-central Gulf of Mexico following the 2010 BP Deepwater Horizon oil spill
    Zhen Tao
    Aquatic Microbiology Laboratory, Department of Fisheries and Allied Aquacultures, Auburn University, Auburn, AL 36849, USA
    Ecohealth 8:507-11. 2011
    ..In this study, we analyzed tar balls for total aerobic bacterial (TAB) counts and also for the presence of Vibrio vulnificus, a human pathogen known to be abundant in the Gulf Coast environment and capable of causing severe wound ..
  15. ncbi Phospholipase A as a potent virulence factor of Vibrio vulnificus
    Bon Sun Koo
    Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561 756, Korea
    Int J Mol Med 20:913-8. 2007
    b>Vibrio vulnificus infection has attracted special interest because of its high mortality rate. However, the identification of its major pathogenic determinant still remains obscure. In this study, a cytolysin-negative mutant strain of V...
  16. pmc Role of iron in human serum resistance of the clinical and environmental Vibrio vulnificus genotypes
    Ryan W Bogard
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 73:7501-5. 2007
    ..Here we report that the clinical genotype of Vibrio vulnificus is significantly better able to survive in human serum than is the environmental genotype...
  17. ncbi Regulation of proinflammatory mediator production in RAW264.7 macrophage by Vibrio vulnificus luxS and smcR
    Na Ri Shin
    Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151 742, South Korea
    FEMS Immunol Med Microbiol 41:169-76. 2004
    b>Vibrio vulnificus causes fatal septicemia in human hosts, which is the consequence of raw shellfish consumption...
  18. ncbi RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis
    Horng Ren Lo
    Institute of Basic Medical Sciences, Taiwan, Republic of China
    J Infect Dis 203:1866-74. 2011
    b>Vibrio vulnificus is a marine bacterium causing serious septicemia and wound infection in humans. It produces an RTX toxin that can lyse a variety of cells and is important for virulence in mice...
  19. ncbi Role of catalase and oxyR in the viable but nonculturable state of Vibrio vulnificus
    In Soo Kong
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28269, USA
    FEMS Microbiol Ecol 50:133-42. 2004
    b>Vibrio vulnificus has proven difficult to culture from water or shellfish during winter months, which is attributed to the viable but nonculturable (VBNC) state...
  20. ncbi Ibuprofen augments pro-inflammatory cytokine release in a mouse model of Vibrio vulnificus infection
    Yuarn Jang Lee
    Section of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei, Taiwan
    Microbiol Immunol 54:542-50. 2010
    ..the effects of ibuprofen on cytokine production and mortality in a mouse model of septic shock induced by Vibrio vulnificus, strain Chi Mei Vv05191...
  21. pmc Cooperative regulation of the Vibrio vulnificus nan gene cluster by NanR protein, cAMP receptor protein, and N-acetylmannosamine 6-phosphate
    Byoung Sik Kim
    National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, South Korea
    J Biol Chem 286:40889-99. 2011
    The nan cluster of Vibrio vulnificus, a food-borne pathogen, consists of two divergently transcribed operons, nanT(PSL)AR and nanEK nagA, required for transport and catabolism of N-acetylneuraminic acid (Neu5Ac)...
  22. pmc USER friendly cloning coupled with chitin-based natural transformation enables rapid mutagenesis of Vibrio vulnificus
    Paul A Gulig
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, 32610 0266, USA
    Appl Environ Microbiol 75:4936-49. 2009
    b>Vibrio vulnificus is a bacterial contaminant of shellfish and causes highly lethal sepsis and destructive wound infections...
  23. ncbi A comprehensive review of Vibrio vulnificus: an important cause of severe sepsis and skin and soft-tissue infection
    Michael A Horseman
    Department of Pharmacy Practice, College of Pharmacy, Texas A and M Health Sciences Center, Kingsville, Texas, USA
    Int J Infect Dis 15:e157-66. 2011
    b>Vibrio vulnificus is a halophilic Gram-negative bacillus found worldwide in warm coastal waters...
  24. ncbi Characterization and virulence of hemolysin III from Vibrio vulnificus
    Yu Chung Chen
    Department of Food Science, National Chung Hsing University, 250 Kuokuang Road, Taichung 402, Taiwan
    Curr Microbiol 49:175-9. 2004
    b>Vibrio vulnificus, a highly virulent marine bacterium, is the causative agent of both serious wound infections and fatal septicemia in many areas of the word. A gene (hlyIII) encoding a hemolysin was cloned and sequenced from V...
  25. pmc Expression of Vibrio vulnificus capsular polysaccharide inhibits biofilm formation
    Lavin A Joseph
    Aquatic Food Products Laboratory, Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Bacteriol 186:889-93. 2004
    b>Vibrio vulnificus is a human pathogen that produces lethal septicemia in susceptible persons, and the primary virulence factor for this organism is capsular polysaccharide (CPS). The role of the capsule in V...
  26. pmc Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus
    Anita Y Lam
    Department of Biochemistry, Biomolecular Structure Center, University of Washington, 1959 Pacific Ave NE, HSC K 428, Seattle, WA 98195, USA
    J Struct Biol 166:8-15. 2009
    ..The crystallization of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus was greatly accelerated by the use of nanobodies, which are the smallest antigen-binding fragments derived ..
  27. ncbi SmcR and cyclic AMP receptor protein coactivate Vibrio vulnificus vvpE encoding elastase through the RpoS-dependent promoter in a synergistic manner
    Hye Sook Jeong
    Departments of Food Science and Technology and of Molecular Biotechnology, Biotechnology Research Institute, Chonnam National University, Kwang ju 500 757
    J Biol Chem 278:45072-81. 2003
    The putative virulence factors of Vibrio vulnificus include an elastase, the gene product of vvpE. We previously demonstrated that vvpE expression is differentially directed by two different promoters in a growth phase-dependent manner...
  28. ncbi Transcriptional regulatory cascade for elastase production in Vibrio vulnificus: LuxO activates luxT expression and LuxT represses smcR expression
    Jong Bok Roh
    Department of Environmental Science, Hankuk University of Foreign Studies, Yongin, Kyunggi Do 449 791, Seoul, South Korea
    J Biol Chem 281:34775-84. 2006
    b>Vibrio vulnificus causes diseases through actions of various virulence factors, including the elastase encoded by the vvpE gene. Through transposon mutagenesis of V. vulnificus, vvpE expression was shown to be increased by luxO mutation...
  29. ncbi RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus
    Kyoung Jin Chung
    School of Dentistry, Dental Science Research Institute, The 2nd Stage of Brain Korea 21 for the Dental School, Chonnam National University, Republic of Korea
    J Infect Dis 201:97-105. 2010
    Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the present study, we employed mutant V...
  30. pmc The capability of catabolic utilization of N-acetylneuraminic acid, a sialic acid, is essential for Vibrio vulnificus pathogenesis
    Hee Gon Jeong
    Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, Research Institute for Agriculture and Life Sciences, Seoul National University, South Korea
    Infect Immun 77:3209-17. 2009
    ..In order to analyze the role of Neu5Ac catabolism in Vibrio vulnificus pathogenesis, a mutant with disruption of the nanA gene encoding Neu5Ac lyase was constructed by allelic ..
  31. pmc HlyU acts as an H-NS antirepressor in the regulation of the RTX toxin gene essential for the virulence of the human pathogen Vibrio vulnificus CMCP6
    Moqing Liu
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Microbiol 72:491-505. 2009
    In Vibrio vulnificus, HlyU upregulates the expression of the large RTX toxin gene. In this work we identified the binding site of HlyU to -417 to -376 bp of the rtxA1 operon transcription start site...
  32. ncbi Climate change and the emergence of Vibrio vulnificus disease in Israel
    S Paz
    Department of Geography and Environmental Studies, University of Haifa, Mount Carmel, Haifa, Israel
    Environ Res 103:390-6. 2007
    In 1996, a major unexplained outbreak of systemic Vibrio vulnificus infection erupted among Israeli fish market workers. The origins of this emergent infectious disease have not been fully understood...
  33. pmc Evaluation of genotypic and phenotypic methods to distinguish clinical from environmental Vibrio vulnificus strains
    Eva Sanjuan
    Departamento de Microbiologia y Ecologia, Universidad de Valencia, Avda Dr Moliner 50, 46100 Burjassot, Valencia, Spain
    Appl Environ Microbiol 75:1604-13. 2009
    b>Vibrio vulnificus is a heterogeneous bacterial species that comprises virulent and avirulent strains from environmental and clinical sources that have been grouped into three biotypes...
  34. ncbi Iron differentially regulates gene expression and extracellular secretion of Vibrio vulnificus cytolysin-hemolysin
    Choon Mee Kim
    Research Center for Resistant Cells, The Institute of Medical Science, and Department of Microbiology, Chosun University Medical School, Gwangju, Republic of Korea
    J Infect Dis 200:582-9. 2009
    In a previous study, we showed that Vibrio vulnificus is a ferrophilic bacterium that requires high levels of available iron for growth...
  35. ncbi Analysis of gene expression in mouse alveolar macrophages stimulated with quorum-sensing mutants of Vibrio vulnificus
    Na Ri Shin
    Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Jpn J Infect Dis 61:402-6. 2008
    ..In this study, microarray technology was used to identify the genes that are affected by the Vibrio vulnificus quorum-sensing genes, luxS and smcR...
  36. ncbi The ecology of Vibrio vulnificus, Vibrio cholerae, and Vibrio parahaemolyticus in North Carolina estuaries
    Karen Dyer Blackwell
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Microbiol 46:146-53. 2008
    ..here we have simultaneously examined several estuarine sites for Vibrio vulnificus, V. cholerae, and V. parahaemolyticus...
  37. ncbi Lower extremity infections by vibrio vulnificus
    G Mouzopoulos
    Department of Evangelismos Hospital, Athens, Greece
    Chirurgia (Bucur) 103:201-3. 2008
    b>Vibrio vulnificus is a Gram-negative pathogen which is found in seawater and shellfish during warm months and can cause local infections in healthy individuals or septicemia in patients with chronic liver disease.
  38. ncbi Characterization of clinical and environmental types of Vibrio vulnificus isolates from Louisiana oysters
    Feifei Han
    Department of Food Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA
    Foodborne Pathog Dis 6:1251-8. 2009
    b>Vibrio vulnificus, a naturally occurring estuarine bacterium frequently transmitted to humans via raw oysters, is a leading cause of seafood-related deaths in the United States...
  39. ncbi Foodborne pathogens in retail oysters in south China
    Yan Chen
    National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China
    Biomed Environ Sci 23:32-6. 2010
    ..To investigate the occurrence of important foodborne pathogens in shellstock Pacific oysters in the food markets in South China...
  40. ncbi Necrotising fasciitis and myositis that originated from gastrointestinal bacterial infection: two fatal cases
    Masaki Fujioka
    Departments of Plastic and Reconstructive Surgery, Fukuoka Tokushukai Medical Center, Fukuoka, Japan
    Scand J Plast Reconstr Surg Hand Surg 37:239-42. 2003
    ..The first patient developed necrosis of the legs over 5 days and he died on the 20th day. Vibrio vulnificus was cultured. The second patient developed bullae on his thigh and he died the next day...
  41. ncbi A highly sensitive and specific multiplex PCR assay for simultaneous detection of Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus
    S B Neogi
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan
    Lett Appl Microbiol 51:293-300. 2010
    To develop an effective multiplex PCR for simultaneous and rapid detection of Vibrio cholerae, Vibrio vulnificus and Vibrio parahaemolyticus, the three most important Vibrio species that can cause devastating health hazards among human.
  42. ncbi The growth of Vibrio vulnificus and the habitat of infected patients in Kumamoto
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 1:134-9. 2007
    In Japan, Vibrio vulnificus (V. vulnificus) infection is very rare, and most infections have occurred in Kumamoto Prefecture (1), and especially around the Ariake and Yatsushiro seas...
  43. pmc Survival of and in situ gene expression by Vibrio vulnificus at varying salinities in estuarine environments
    Melissa K Jones
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 74:182-7. 2008
    The opportunistic human pathogen Vibrio vulnificus survives in a wide range of ecological environments, which demonstrates its ability to adapt to highly variable conditions...
  44. pmc Direct interaction between quorum-sensing regulator SmcR and RNA polymerase is mediated by integration host factor to activate vvpE encoding elastase in Vibrio vulnificus
    Hye Sook Jeong
    National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, South Korea
    J Biol Chem 285:9357-66. 2010
    ..We previously revealed that SmcR, a LuxR homologue of Vibrio vulnificus, activates promoter S, an RpoS-dependent promoter of vvpE encoding a potential virulence factor elastase and ..
  45. pmc Necrotizing fasciitis from Vibrio vulnificus in a patient with undiagnosed hepatitis and cirrhosis
    Kenneth L Muldrew
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Microbiol 45:1058-62. 2007
    Necrotizing fasciitis due to Vibrio vulnificus may result in overwhelming sepsis, leading to death in some patients. Significant risk factors for severe disease include preexisting liver disease...
  46. ncbi Insights into the antibacterial and immunomodulatory functions of tilapia hepcidin (TH)2-3 against Vibrio vulnificus infection in mice
    Chieh Yu Pan
    Department of Aquaculture, National Taiwan Ocean University, Keelung 202, Taiwan
    Dev Comp Immunol 36:166-73. 2012
    ..investigated the antibacterial and immunomodulatory functions of TH2-3 in mice infected with the pathogen, Vibrio vulnificus. A TH2-3 injection in V...
  47. ncbi [A collective review of Vibrio vulnificus infection in Japan]
    Hirotaka Oishi
    Ariake Sea Research Project, Saga University
    Kansenshogaku Zasshi 80:680-9. 2006
    b>Vibrio vulnificus is found globally in marine coastal waters...
  48. pmc Vibrio vulnificus rpoS expression is repressed by direct binding of cAMP-cAMP receptor protein complex to its two promoter regions
    Hyun Jung Lee
    Department of Environmental Science, Hankuk University of Foreign Studies, Yongin 449 791, South Korea
    J Biol Chem 283:30438-50. 2008
    b>Vibrio vulnificus, a septicemia-causing pathogenic bacterium, acquires resistance against various stresses and expresses virulence factors via an rpoS gene product...
  49. ncbi A conserved GTPase YchF of Vibrio vulnificus is involved in macrophage cytotoxicity, iron acquisition, and mouse virulence
    Yu Chung Chen
    Department of Biotechnology, College of Pharmacy and Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Int J Med Microbiol 301:469-74. 2011
    b>Vibrio vulnificus, a highly virulent marine bacterium, causes serious wound infections and fatal septicemia in many areas of the world. To identify V...
  50. pmc Cyclic-di-GMP regulates extracellular polysaccharide production, biofilm formation, and rugose colony development by Vibrio vulnificus
    Alina Nakhamchik
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    Appl Environ Microbiol 74:4199-209. 2008
    b>Vibrio vulnificus is a human and animal pathogen that carries the highest death rate of any food-borne disease agent. It colonizes shellfish and forms biofilms on the surfaces of plankton, algae, fish, and eels...
  51. ncbi Crystal structure of the transcriptional activator HlyU from Vibrio vulnificus CMCP6
    Kosuke Nishi
    Department of Chemistry, Chonnam National University, Gwangju, Republic of Korea
    FEBS Lett 584:1097-102. 2010
    HlyU is a transcription factor of the ArsR/SmtB family and activates the expression of the pathogenic Vibrio vulnificus RTX toxin. In contrast to the other metal-responding ArsR/SmtB proteins, HlyU does not sense metal ions...
  52. pmc Ecology of Vibrio vulnificus in estuarine waters of eastern North Carolina
    Courtney S Pfeffer
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Appl Environ Microbiol 69:3526-31. 2003
    While several studies on the ecology of Vibrio vulnificus in Gulf Coast environments have been reported, there is little information on the distribution of this pathogen in East Coast waters...
  53. ncbi Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 35:129-39. 2008
    The frequency of Vibrio vulnificus infection is very rare and there are many questions regarding its epidemiology in Japan. To investigate the clinical course and epidemiology of V...
  54. ncbi Methods for isolation and confirmation of Vibrio vulnificus from oysters and environmental sources: a review
    Valerie J Harwood
    Department of Biology, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA
    J Microbiol Methods 59:301-16. 2004
    The gram-negative bacterium Vibrio vulnificus is a natural inhabitant of estuarine waters and poses a significant health threat to humans who suffer from immune disorders, liver disease, or hemochromatosis (iron overload). V...
  55. ncbi Clinical features of Vibrio vulnificus infections in the coastal areas of the Ariake Sea, Japan
    Kouichi Matsumoto
    Ariake Sea Research Project, Saga University, Saga, Japan
    J Infect Chemother 16:272-9. 2010
    b>Vibrio vulnificus infection can result in necrotizing fasciitis and sepsis and is associated with high mortality. Most patients infected with this microbe have liver dysfunction as an underlying disease...
  56. ncbi Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains
    Jiyou Wang
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Microb Pathog 44:494-500. 2008
    b>Vibrio vulnificus is a causative agent of septicemia or wound infection in human and eel; however, the genetic variation between human and eel isolates has been reported...
  57. pmc Vibrio vulnificus biotype 2 serovar E gne but not galE is essential for lipopolysaccharide biosynthesis and virulence
    Esmeralda Valiente
    Departamento de Microbiologia y Ecologia, Universidad de Valencia, C Dr Moliner, 50, Burjasot, Valencia, Spain
    Infect Immun 76:1628-38. 2008
    ..of surface polysaccharides, as well as in the virulence for eels and humans of the zoonotic serovar of Vibrio vulnificus biotype 2, serovar E...
  58. ncbi Multiplex PCR detection of clinical and environmental strains of Vibrio vulnificus in shellfish
    Gitika Panicker
    Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294 1170, USA
    Can J Microbiol 50:911-22. 2004
    In this study, we developed a PCR-based rapid detection method for clinically important pathogenic strains of Vibrio vulnificus. Positive amplification of the 504-bp viuB fragment was seen in all 22 clinical isolates tested but only in 8 ..
  59. ncbi Production of Vibrio vulnificus hemolysin in vivo and its pathogenic significance
    Shee Eun Lee
    Department of Dental Pharmacology, Chonnam National University, Gwangju 500 757, Republic of Korea
    Biochem Biophys Res Commun 324:86-91. 2004
    Hemolyin/cytolysin (VvhA) is one of the representative exotoxins produced by Vibrio vulnificus. Cytotoxic mechanism of VvhA has been extensively studied...
  60. pmc Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo
    Takashige Kashimoto
    Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23 35 1, Towada Aomori 034 8628, Japan
    Infect Immun 71:533-5. 2003
    In this study, we compared the apoptotic activities of clinical and environmental isolates of Vibrio vulnificus toward macrophages in vitro and in vivo...
  61. pmc Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus
    Moqing Liu
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 193:6895-901. 2011
    ..The virulence gene rtxA1, encoding the repeat-in-toxin protein, plays an essential role in the pathogenesis of Vibrio vulnificus infections...
  62. pmc Identification of the emerging pathogen Vibrio vulnificus biotype 3 by commercially available phenotypic methods
    Raul Colodner
    Clinical Microbiology Laboratory, Ha Emek Medical Center, Afula 18101, Israel
    J Clin Microbiol 42:4137-40. 2004
    Identification of the emerging pathogen Vibrio vulnificus biotype 3 has become a challenge for clinical laboratories in the last few years...
  63. pmc Isolation and characterization of rpoS from a pathogenic bacterium, Vibrio vulnificus: role of sigmaS in survival of exponential-phase cells under oxidative stress
    Kyung Je Park
    Department of Environmental Science, Hankuk University of Foreign Studies, Yongin, Kyunggi Do 449 791, Korea
    J Bacteriol 186:3304-12. 2004
    A gene homologous to rpoS was cloned from a fatal human pathogen, Vibrio vulnificus. The functional role of rpoS in V. vulnificus was accessed by using an rpoS knockout mutant strain...
  64. ncbi Immune response and inhibition of bacterial growth by electrotransfer of plasmid DNA containing the antimicrobial peptide, epinecidin-1, into zebrafish muscle
    Shih Bin Lin
    Department of Food Science, National I Lan University, 1 Shen Lung Rd, Sec 1, Ilan 260, Taiwan
    Fish Shellfish Immunol 26:451-8. 2009
    ..These data demonstrate that electroporation of epinecidin-1 might have provoked an inflammatory response that accounts for the improvement in bacterial clearance...
  65. ncbi Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus
    Byung Cheol Lee
    School of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul 136 701, Republic of Korea
    Microbes Infect 10:1504-13. 2008
    During Vibrio vulnificus infection, V. vulnificus reaches the intestine and then invades the bloodstream by crossing the intestinal mucosal barrier of the host, which results in systemic septicemia...
  66. ncbi Occurrence, seasonality and genetic diversity of Vibrio vulnificus in coastal seaweeds and water along the Kii Channel, Japan
    Zahid Hayat Mahmud
    Environmental Microbiology Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh
    FEMS Microbiol Ecol 64:209-18. 2008
    b>Vibrio vulnificus is a ubiquitous toxigenic bacterium found in a coastal environment but little is known about its occurrence and seasonality among seaweeds, which are widely consumed as seafood in Japan...
  67. pmc Additive function of Vibrio vulnificus MARTX(Vv) and VvhA cytolysins promotes rapid growth and epithelial tissue necrosis during intestinal infection
    Hee Gon Jeong
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Pathog 8:e1002581. 2012
    b>Vibrio vulnificus is a pathogen that causes both severe necrotizing wound infections and life-threatening food-borne infections...
  68. ncbi Role of NtrC-regulated exopolysaccharides in the biofilm formation and pathogenic interaction of Vibrio vulnificus
    Han Suk Kim
    Department of Environmental Science and Protein Research Center for Bio Industry, Hankuk University of Foreign Studies, Yongin, Kyunggi Do 449 791, South Korea
    Mol Microbiol 74:436-53. 2009
    b>Vibrio vulnificus has been shown to require a global transcription factor, NtrC for mature biofilm development via controlling the biosyntheses of lipopolysaccharide and exopolysaccharide (EPS)...
  69. ncbi Involvement of capsular polysaccharide via a TLR2/NF-kappaB pathway in Vibrio vulnificus-induced IL-8 secretion of human intestinal epithelial cells
    Byung Cheol Lee
    Division of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Int J Mol Med 25:581-91. 2010
    In a previous study, we reported that a wbpP gene mutation in Vibrio vulnificus was significantly impaired in its ability to synthesize surface capsular polysaccharide (CPS). In this study, we evaluated the functions of the V...
  70. pmc Wound infections caused by Vibrio vulnificus and other marine bacteria
    J D Oliver
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA
    Epidemiol Infect 133:383-91. 2005
    Infections caused by Vibrio vulnificus were first reported in 1979 by Blake et al. of the US Centers for Disease Control. At that time described as a 'rare, unnamed halophilic lactose-fermenting Vibrio species', V...
  71. pmc Tumor necrosis factor-α and mortality in patients infected with Vibrio vulnificus
    Jun Young Lee
    Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea
    Am J Trop Med Hyg 84:426-8. 2011
    Serum tumor necrosis factor-α (TNF-α) was evaluated in Vibrio vulnificus-infected patients at admission. The median TNF-α concentration in the non-survivor group was determined to be 261.0 pg/mL, in contrast to 69...
  72. ncbi Vibrio vulnificus oysters: pearls and perils
    Nicholas A Daniels
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Clin Infect Dis 52:788-92. 2011
    b>Vibrio vulnificus is a naturally occurring bacterium found ubiquitously in coastal waters...
  73. ncbi Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species
    Jung Chen Hsieh
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23 10 Dahuen Rd, Jiaushi, Ilan 262, Taiwan
    Fish Shellfish Immunol 29:430-9. 2010
    ..In vivo, transgenic TH2-3 fish (of the F3 generation) were challenged with Vibrio vulnificus (204) and Streptococcus agalactiae (SA). Results showed significant clearance of bacterial numbers of V...
  74. pmc Roles of RseB, sigmaE, and DegP in virulence and phase variation of colony morphotype of Vibrio vulnificus
    Roslyn N Brown
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610 0266, USA
    Infect Immun 77:3768-81. 2009
    b>Vibrio vulnificus is an estuarine bacterium capable of causing serious and often fatal wound infections and primary septicemia...
  75. pmc Complete genome sequence of Vibrio vulnificus MO6-24/O
    Jin Hwan Park
    National Research Laboratory of Molecular Microbiology and Toxicology, Center for Food Safety and Toxicology, and Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    J Bacteriol 193:2062-3. 2011
    b>Vibrio vulnificus is the causative agent of life-threatening septicemia and severe wound infections. Here, we announce the complete annotated genome sequence of V. vulnificus MO6-24/O, isolated from a patient with septicemia...
  76. pmc Population genetics of Vibrio vulnificus: identification of two divisions and a distinct eel-pathogenic clone
    Michaela Gutacker
    Istituto Cantonale di Microbiologia, 6501 Bellinzona, Switzerland
    Appl Environ Microbiol 69:3203-12. 2003
    Genetic relationships among 62 Vibrio vulnificus strains of different geographical and host origins were analyzed by multilocus enzyme electrophoresis (MLEE), random amplification of polymorphic DNA (RAPD), and sequence analyses of the ..
  77. ncbi Autopsy cases of fulminant-type bacterial infection with necrotizing fasciitis: group A (beta) hemolytic Streptococcus pyogenes versus Vibrio vulnificus infection
    Takuma Tajiri
    Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Pathol Int 58:196-202. 2008
    ..was a woman with group A (beta) hemolytic Streptococcus pyogenes infection, and the latter was a man with Vibrio vulnificus infection...
  78. ncbi Two cases of severe sepsis due to Vibrio vulnificus wound infection acquired in the Baltic Sea
    J Ruppert
    Department of Internal Medicine B, University of Greifswald, Germany
    Eur J Clin Microbiol Infect Dis 23:912-5. 2004
    Two severe cases of Vibrio vulnificus wound infection with secondary septicemia occurred during 1 week in August 2003 on the German island of Usedom in the southwestern Baltic Sea...
  79. pmc Vibrio vulnificus DNA load and mortality
    Dong Min Kim
    Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwang Ju, South Korea
    J Clin Microbiol 49:413-5. 2011
    We determined the association between DNA load and mortality in patients with Vibrio vulnificus infection...
  80. pmc Genotype is correlated with but does not predict virulence of Vibrio vulnificus biotype 1 in subcutaneously inoculated, iron dextran-treated mice
    Patrick C Thiaville
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA
    Infect Immun 79:1194-207. 2011
    b>Vibrio vulnificus is the leading cause of reported deaths from infections related to consumption of seafood in the United States. Affected predisposed individuals frequently die rapidly from sepsis...
  81. ncbi Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection
    Jong Ro Kim
    Department of Oriental Medicine Materials, Dongshin University, Jeonnam, 520 714, Republic of Korea
    J Microbiol 46:737-43. 2008
    b>Vibrio vulnificus, a good model organism of bacterial septicemia, causes fatal septicemia manifesting a fulminating course and a high mortality rate within days. In order to identify new natural substances preventing V...
  82. pmc Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence
    Na Young Park
    Department of Food Science and Technology, School of Agricultural Biotechnology, Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, South Korea
    Infect Immun 74:721-8. 2006
    A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C(4) epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its ..
  83. pmc Real-time PCR detection of Vibrio vulnificus in oysters: comparison of oligonucleotide primers and probes targeting vvhA
    Gitika Panicker
    Department of Biology, University of Alabama at Birmingham, 1300 University Blvd, Campbell Hall, rm 102, Birmingham, AL 35294 1170, USA
    Appl Environ Microbiol 71:5702-9. 2005
    We compared three sets of oligonucleotide primers and two probes designed for Vibrio vulnificus hemolysin A gene (vvhA) for TaqMan-based real-time PCR method enabling specific detection of Vibrio vulnificus in oysters...
  84. ncbi Role of GacA in virulence of Vibrio vulnificus
    Julie D Gauthier
    Food Science and Human Nutrition Department, 212 Aquatic Food Products Laboratory, University of Florida, Gainesville, FL 32611, USA
    Microbiology 156:3722-33. 2010
    ..The present study investigated this regulatory pathway in Vibrio vulnificus, a human pathogen that causes life-threatening disease associated with the consumption of raw oysters and ..
  85. ncbi Fate of Staphylococcus aureus, Salmonella enterica serovar typhimurium, and vibrio vulnificus in raw oysters treated with chitosan
    Pallavi Chhabra
    Department of Food Science and Technology, University of Georgia, Athens, Georgia 30602, USA
    J Food Prot 69:1600-4. 2006
    The fate of Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and Vibrio vulnificus in oysters treated with chitosan was investigated. Three concentrations (0.5, 1.0, and 2.0%) of chitosan in 0...
  86. ncbi Role of NtrC in biofilm formation via controlling expression of the gene encoding an ADP-glycero-manno-heptose-6-epimerase in the pathogenic bacterium, Vibrio vulnificus
    Han Suk Kim
    Department of Environmental Science, Hankuk University of Foreign Studies, Yongin, Kyunggi Do 449 791, Korea
    Mol Microbiol 63:559-74. 2007
    To identify the genetic elements required for biofilm formation, we screened a pool of random Vibrio vulnificus mutants for their ability to form biofilms...
  87. ncbi Septic arthritis as the initial manifestation of fatal Vibrio vulnificus septicemia in a patient with thalassemia and iron overload
    Chang Hung Kuo
    Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pediatr Blood Cancer 53:1156-8. 2009
    b>Vibrio vulnificus infection is an uncommon but potentially fatal disease in children such that prompt recognition has prognostic implications...
  88. pmc Identification of a c-di-GMP-regulated polysaccharide locus governing stress resistance and biofilm and rugose colony formation in Vibrio vulnificus
    Yunzhi Guo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Infect Immun 78:1390-402. 2010
    As an etiological agent of bacterial sepsis and wound infections, Vibrio vulnificus is unique among the Vibrionaceae...
  89. ncbi Hemochromatosis and Vibrio vulnificus wound infections
    James C Barton
    Southern Iron Disorders Center Departments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Gastroenterol 43:890-3. 2009
    There are several reports of persons with hemochromatosis and Vibrio vulnificus primary septicemia, but few accounts of persons with hemochromatosis and V. vulnificus wound infection...
  90. pmc Crystal structure of SmcR, a quorum-sensing master regulator of Vibrio vulnificus, provides insight into its regulation of transcription
    Yoonjeong Kim
    Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806
    J Biol Chem 285:14020-30. 2010
    ..SmcR, a homologue of Vibrio harveyi LuxR, has been proposed as a quorum-sensing master regulator of Vibrio vulnificus, an opportunistic human pathogen...
  91. ncbi Structure of a polysaccharide from the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 containing 2-acetimidoylamino-2-deoxy-L-galacturonic acid
    Sof ya N Senchenkova
    N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Carbohydr Res 344:1009-13. 2009
    A polysaccharide isolated after mild acid degradation of the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 was found to contain L-Fuc, D-GlcpNAc, 2,4-diacetamido-2,4,6-trideoxy-D-glucose (di-N-acetylbacillosamine, D-..
  92. ncbi Complete sequence of plasmid pMP1 from the marine environmental Vibrio vulnificus and location of its replication origin
    Ruifu Zhang
    Laboratory of Environmental Microbiology and Toxicology, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, People s Republic of China
    Mar Biotechnol (NY) 11:456-62. 2009
    A novel cryptic plasmid, pMP1, from an environmental Vibrio vulnificus MP-4 isolated from Mai Po Nature Reserve in Hong Kong, has been characterized. The 7.6-kb plasmid had guanine-cytosine content of 40...
  93. ncbi Role of the virulence plasmid pR99 and the metalloprotease Vvp in resistance of Vibrio vulnificus serovar E to eel innate immunity
    E Valiente
    Department of Microbiology and Ecology, University of Valencia, Dr Moliner 50, 46100 Burjassot, Valencia, Spain
    Fish Shellfish Immunol 24:134-41. 2008
    b>Vibrio vulnificus biotype 2 serovar E (VSE) is a bacterial pathogen that produces a haemorrhagic septicaemia called vibriosis in eels...
  94. ncbi Outer membrane vesicles of Vibrio vulnificus deliver cytolysin-hemolysin VvhA into epithelial cells to induce cytotoxicity
    Young Ran Kim
    Clinical Vaccine R and D Center, Chonnam National University Medical School, Gwangju 501 746, Republic of Korea
    Biochem Biophys Res Commun 399:607-12. 2010
    The Gram-negative bacterium Vibrio vulnificus produces cytotoxins that induce the acute death of host cells. However, the secretory mechanisms of such cytotoxins have not been extensively studied...
  95. ncbi Vibrio vulnificus cytolysin induces apoptosis in HUVEC, SGC-7901 and SMMC-7721 cells via caspase-9/3-dependent pathway
    Jin fang Zhao
    Basic Medical Microbiology Division, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, Zhejiang, PR China
    Microb Pathog 46:194-200. 2009
    b>Vibrio vulnificus cytolysin (VVC) is known to be a pore-forming toxin which shows cytotoxicity for mammalian cells in culture and induces apoptosis in endothelial cells...
  96. pmc The pyrH gene of Vibrio vulnificus is an essential in vivo survival factor
    Shee Eun Lee
    Clinical Vaccine R and D Center and Department of Biomedical Sciences and Microbiology, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Gwangju 501 746, South Korea
    Infect Immun 75:2795-801. 2007
    We have suggested an important role of the pyrH gene during the infectious process of Vibrio vulnificus. Previously, we have identified 12 genes expressed preferentially during human infections by using in vivo-induced antigen technology...
  97. pmc Refined medium for direct isolation of Vibrio vulnificus from oyster tissue and seawater
    Elizabeth Warner
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 73:3098-100. 2007
    We have developed a new medium for the direct isolation of Vibrio vulnificus from water and oyster samples. The medium was shown in laboratory and field studies to be highly selective without providing preferential isolation of either V...
  98. ncbi Membrane cholesterol is required for activity of Vibrio vulnificus cytolysin
    Hong Nu Yu
    Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Microbiol 187:467-73. 2007
    b>Vibrio vulnificus cytolysin (VVC) forms a pore in the plasma membrane and induces cytolysis of various cells including erythrocytes, neutrophil and endothelial cells...
  99. ncbi Identification of the Vibrio vulnificus ahpCl gene and its influence on survival under oxidative stress and virulence
    Woon Ki Baek
    National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Agricultural Biomaterials, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea
    J Microbiol 47:624-32. 2009
    ..study, ahpCl, a homologue of Escherichia coli ahpC encoding a peroxiredoxin, was identified among the Vibrio vulnificus genes specifically induced by exposure to H(2)O(2)...
  100. ncbi Essential role of an adenylate cyclase in regulating Vibrio vulnificus virulence
    Young Ran Kim
    Research Institute of Vibrio Infection and Genome Research Center for Enteropathogenic Bacteria, Chonnam National University Medical School, Gwangju 501 746, South Korea
    FEMS Microbiol Lett 243:497-503. 2005
    b>Vibrio vulnificus, a halophilic estuarine bacterium, causes a fatal septicemia and necrotizing wound infection. To investigate the role of cAMP in V...
  101. ncbi Quorum sensing in vibrios: complexity for diversification
    Debra L Milton
    Department of Molecular Biology, Umea University, SE 90187 Umea, Sweden
    Int J Med Microbiol 296:61-71. 2006
    ..Further studies are likely to show that the diversity and complexity of the Vibrio quorum-sensing systems coordinate intraspecies behaviour, niche occupation, and possibly evolution...

Research Grants17

  1. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani...
  2. Mechanism of Cell Membrane Targeting by Vibrio Cholerae Cytolysin
    RICHARD A OLSON; Fiscal Year: 2012
    ..on a variety of VCC toxin homologs with important human health implications, including toxins produced by Vibrio vulnificus, a cause of deadly food poisoning and sepsis...
  3. Structure and function of prokaryotic appendages by cryo-electron tomography
    Elizabeth R Wright; Fiscal Year: 2013
    ..To answer these questions, we are using several bacterial species, Vibrio cholerae and Vibrio vulnificus, human pathogens that cause severe gastroenteritis, diarrhea, and death;and Caulobacter crescentus, a well-..
  4. Function of Vibrio vulnificus MARTX toxin during early gut infection
    Karla J F Satchell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vibrio vulnificus is a natural inhabitant of coastal waters, including the US Gulf...
  5. Molecular mechanism of V. vulnificus MARTX toxin in pathogenesis and food safety
    Karla J F Satchell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vibrio vulnificus is a natural inhabitant of coastal waters, including the US Gulf...
  6. Shellfish Safety Assistance Project
    KENNETH B MOORE; Fiscal Year: 2010
    ..and the assurance of conformity to the National Shellfish Sanitation Program;and provide for research on Vibrio vulnificus, which can cause serious illness and death in individuals with certain preexisting conditions and on Vibrio ..
  7. IRON ACQUISITION AND VIRULENCE OF VIBRIO VULNIFICUS
    CHRISTINE LITWIN; Fiscal Year: 2002
    ..proposal are to study the role of iron in bacterial pathogenesis, specifically focusing on the pathogen, Vibrio vulnificus. Iron plays a very important role in the pathogenesis of V. vulnificus infections...
  8. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2007
    b>Vibrio vulnificus is a gram-negative bacterium that causes fulminating diseases in susceptible humans: septicemia after ingestion of oysters and wound infection from sea water. The major predisposing factor is iron overload...
  9. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  10. Iron Uptake and Virulence of Burkholderia pseudomallei
    JORGE CROSA; Fiscal Year: 2005
    ..Knowledge gained from our investigation will contribute to the development of measures to control the diseases caused by these pathogens. ..
  11. CLINICAL RESEARCH CURRICULM AWARD
    John Morris; Fiscal Year: 2004
    ..Details are provided in the body of this application. ..
  12. ADH GENOTYPE, ALC ABUSE & CELL RESPONSE TO V VULNIFICUS
    Jan Powell; Fiscal Year: 2004
    ..ADH) genotype, alcohol abuse, immune status and cellular response to environmental food-borne pathogen Vibrio vulnificus. Individuals that abuse alcohol are at increased risk of developing septicemia and cytokine-mediated shock ..
  13. CHEMISTRY OF THE POLYSACCHARIDE OF V CHOLERAE 0139
    C Bush; Fiscal Year: 2001
    ..Oligosaccharide fragments will test the hypothesis of a conformational epitope that depends on molecular size. The oligosaccharides are to be used in development of chemically modified protein conjugates for vaccine development. ..
  14. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2004
    ..cholerae surface polysaccharides and, in turn, for the emergence of V. cholerae strains which can form the basis for new cholera pandemics. ..