streptococcus mutans

Summary

Summary: A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.

Top Publications

  1. ncbi Effects of glucose and fluoride on competition and metabolism within in vitro dental bacterial communities and biofilms
    D J Bradshaw
    CAMR, Salisbury, Wilts, Port Sunlight Laboratory, Bebington, Merseyside, UK
    Caries Res 36:81-6. 2002
  2. ncbi Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm
    Doron Steinberg
    Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University Hadassah, PO Box 12272, Jerusalem, 91120, Israel
    J Antimicrob Chemother 54:86-9. 2004
  3. pmc Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans
    Jacob P Bitoun
    Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, USA
    FEMS Microbiol Lett 320:110-7. 2011
  4. ncbi Archwire ligation techniques, microbial colonization, and periodontal status in orthodontically treated patients
    Hakan Turkkahraman
    Department of Orthodontics, Faculty of Dentistry, University of Suleyman Demirel, Isparta, Turkey
    Angle Orthod 75:231-6. 2005
  5. pmc Regulation of the competence pathway as a novel role associated with a streptococcal bacteriocin
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:6552-9. 2011
  6. ncbi Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms
    Simone Duarte
    Eastman Department of Dentistry Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    FEMS Microbiol Lett 257:50-6. 2006
  7. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
  8. pmc Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, P O Box 951668, Los Angeles, CA 90095 1668, USA
    J Bacteriol 187:7193-203. 2005
  9. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
  10. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010

Detail Information

Publications324 found, 100 shown here

  1. ncbi Effects of glucose and fluoride on competition and metabolism within in vitro dental bacterial communities and biofilms
    D J Bradshaw
    CAMR, Salisbury, Wilts, Port Sunlight Laboratory, Bebington, Merseyside, UK
    Caries Res 36:81-6. 2002
    ..pH 4.5 following glucose pulses, and the community was dominated by Streptococcus mutans (rising from 4 to 23% of total CFU) and Veillonella dispar (16 to 73%)...
  2. ncbi Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm
    Doron Steinberg
    Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University Hadassah, PO Box 12272, Jerusalem, 91120, Israel
    J Antimicrob Chemother 54:86-9. 2004
    ..Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria...
  3. pmc Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans
    Jacob P Bitoun
    Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, USA
    FEMS Microbiol Lett 320:110-7. 2011
    ..b>Streptococcus mutans, the primary causative agent of human dental caries, possesses a gene that encodes a protein with high ..
  4. ncbi Archwire ligation techniques, microbial colonization, and periodontal status in orthodontically treated patients
    Hakan Turkkahraman
    Department of Orthodontics, Faculty of Dentistry, University of Suleyman Demirel, Isparta, Turkey
    Angle Orthod 75:231-6. 2005
    ..However, teeth ligated with elastomeric rings were more prone to bleeding. Therefore, elastomeric ring use is not recommended in patients with poor oral hygiene...
  5. pmc Regulation of the competence pathway as a novel role associated with a streptococcal bacteriocin
    Delphine Dufour
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:6552-9. 2011
    The oral biofilm organism Streptococcus mutans must face numerous environmental stresses to survive in its natural habitat. Under specific stresses, S...
  6. ncbi Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms
    Simone Duarte
    Eastman Department of Dentistry Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    FEMS Microbiol Lett 257:50-6. 2006
    Cranberry fruit is a rich source of polyphenols, and has shown biological activities against Streptococcus mutans. In the present study, we examined the influence of extracts of flavonols (FLAV), anthocyanins (A) and proanthocyanidins (..
  7. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
    ..in cranberry extracts has been linked to biological activities against specific virulence attributes of Streptococcus mutans, e.g. the inhibition of glucosyltransferase (Gtf) activity...
  8. pmc Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, P O Box 951668, Los Angeles, CA 90095 1668, USA
    J Bacteriol 187:7193-203. 2005
    ..In this study, we used two oral bacterial species, Streptococcus mutans and Streptococcus sanguinis (formerly S...
  9. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
    The importance of Streptococcus mutans in the etiology and pathogenesis of dental caries is certainly controversial, in part because excessive attention is paid to the numbers of S...
  10. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010
    Previous work suggested that the underlying mechanisms by which the Streptococcus mutans ClpXP protease affects virulence traits are associated with accumulation of two orthologues of the Spx regulator, named SpxA and SpxB...
  11. ncbi Protein expression by planktonic and biofilm cells of Streptococcus mutans
    G Svensater
    Department of Oral Biology, Centre for Oral Health Sciences, Malmo University, Malmo, Sweden
    FEMS Microbiol Lett 205:139-46. 2001
    b>Streptococcus mutans, a major causal agent of dental caries, functions in nature as a component of a biofilm on teeth (dental plaque) and yet very little information is available on the physiology of the organism in such surface-..
  12. pmc The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 79:2277-84. 2011
    b>Streptococcus mutans is considered the primary etiologic agent of dental caries, a global health problem that affects 60 to 90% of the population, and a leading causative agent of infective endocarditis...
  13. ncbi Role of eDNA on the adhesion forces between Streptococcus mutans and substratum surfaces: influence of ionic strength and substratum hydrophobicity
    Theerthankar Das
    Department of Biomedical Engineering, W J Kolff Institute, University Medical Center Groningen and University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Langmuir 27:10113-8. 2011
    The aim of this study was to investigate the role of extracellular DNA (eDNA) on the adhesion strength of Streptococcus mutans LT11 on substrata with different hydrophobicities at high and low ionic strengths...
  14. pmc Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance
    Chenggang Wu
    College of Dentistry, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Appl Environ Microbiol 76:5815-26. 2010
    The oral biofilm community consists of >800 microbial species, among which Streptococcus mutans is considered a primary pathogen for dental caries. The genomic island TnSmu2 of S. mutans comprises >2% of the genome...
  15. ncbi A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis
    I Kleinberg
    Department of Oral Biology and Pathology, State University of New York, Stony Brook, New York 11794 8702, USA
    Crit Rev Oral Biol Med 13:108-25. 2002
    ..Frequent association of Lactobacillus acidophilus and Streptococcus mutans with caries activity gave credence to their being specific cariogens...
  16. ncbi Effect of orthodontic treatment on saliva, plaque and the levels of Streptococcus mutans and Lactobacillus
    Edith Lara-Carrillo
    Department of Orthodontics, Research Center, School of Dentistry, Universidad Autonoma del Estado de Mexico, Toluca, Estado de Mexico, Mexico
    Med Oral Patol Oral Cir Bucal 15:e924-9. 2010
    ..The aim of this study was to identify changes in the oral environment with clinical, salivary and bacterial risk markers after placement of fixed orthodontic appliances on permanent dentition...
  17. pmc Acid tolerance mechanisms utilized by Streptococcus mutans
    Robert Matsui
    Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, ON, M5G 1G6, Canada
    Future Microbiol 5:403-17. 2010
    Since its discovery in 1924 by J Clarke, Streptococcus mutans has been the focus of rigorous research efforts due to its involvement in caries initiation and progression...
  18. pmc The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans
    Jing Ouyang
    Department of Applied Oral Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Antimicrob Agents Chemother 54:3895-906. 2010
    b>Streptococcus mutans is known to be resistant to bacitracin, a cyclic polypeptide antibiotic produced by certain species of the genus Bacillus. This property is often exploited in the isolation of S...
  19. ncbi PCR ligation mutagenesis in transformable streptococci: application and efficiency
    Peter C Y Lau
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontorio, Canada
    J Microbiol Methods 49:193-205. 2002
    ..be reliably employed for the systematic generation of gene deletion mutants in both highly transformable Streptococcus mutans and S. pneumoniae...
  20. ncbi Streptococcus mutans autolysin AtlA is a fibronectin-binding protein and contributes to bacterial survival in the bloodstream and virulence for infective endocarditis
    Chiau Jing Jung
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1, Jen Ai Road Section 1, Taipei, 10051, Taiwan
    Mol Microbiol 74:888-902. 2009
    b>Streptococcus mutans, a commensal of the human oral cavity, can survive in the bloodstream and cause infective endocarditis (IE). However, the virulence factors associated with this manifestation of disease are not known...
  21. pmc Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content
    Fumito Maruyama
    Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    BMC Genomics 10:358. 2009
    b>Streptococcus mutans is the major pathogen of dental caries, and it occasionally causes infective endocarditis...
  22. pmc Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms
    H Koo
    Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:3024-32. 2010
    b>Streptococcus mutans is a key contributor to the formation of the extracellular polysaccharide (EPS) matrix in dental biofilms...
  23. pmc Glucan-binding proteins are essential for shaping Streptococcus mutans biofilm architecture
    David J Lynch
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA
    FEMS Microbiol Lett 268:158-65. 2007
    Glucan plays a central role in sucrose-dependent biofilm formation by the dental pathogen Streptococcus mutans. This organism synthesizes several proteins capable of binding glucan...
  24. ncbi Antibacterial activity of polyphenol components in oolong tea extract against Streptococcus mutans
    H Sasaki
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    Caries Res 38:2-8. 2004
    ..study was to determine the antibacterial activity of oolong tea extract on oral streptococci, including Streptococcus mutans and Streptococcus sobrinus, and to identify the response to its components...
  25. ncbi The complex oral microflora of high-risk individuals and groups and its role in the caries process
    David Beighton
    Department of Microbiology, Dental Institute, King s College London, London, UK
    Community Dent Oral Epidemiol 33:248-55. 2005
    ..The essential role of mutans streptococci (Streptococcus mutans and Streptococcus sobrinus) in the caries process is not proven...
  26. pmc Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 44:3313-7. 2006
    ..However, no information is available regarding the involvement of cariogenic pathogens such as Streptococcus mutans. The presence of oral streptococcal species and periodontitis-related bacteria in 35 heart valve and 27 ..
  27. pmc Natural genetic transformation of Streptococcus mutans growing in biofilms
    Y H Li
    Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 183:897-908. 2001
    b>Streptococcus mutans is a bacterium that has evolved to be dependent upon a biofilm "lifestyle" for survival and persistence in its natural ecosystem, dental plaque...
  28. pmc Transcriptional regulation of the cellobiose operon of Streptococcus mutans
    Lin Zeng
    Department of Oral Biology, University of Florida, Gainesville, 32610, USA
    J Bacteriol 191:2153-62. 2009
    The ability of Streptococcus mutans to catabolize cellobiose, a beta-linked glucoside generated during the hydrolysis of cellulose, is shown to be regulated by a transcriptional regulator, CelR, which is encoded by an operon with a ..
  29. ncbi Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Cell-surface structures of novel serotype k Streptococcus mutans strains and their correlation to virulence
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Pharmacol Sci 113:120-5. 2010
    b>Streptococcus mutans is generally known as a pathogen of dental caries, and it is also considered to cause bacteremia and infective endocarditis (IE). S...
  30. pmc A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development
    M Dilani Senadheera
    Dental Research Institute, University of Toronto, 124 Edward Street, Toronto ON M51G6, Canada
    J Bacteriol 187:4064-76. 2005
    ..This study describes the vicRK signal transduction system in Streptococcus mutans. A vicK (putative histidine kinase) deletion mutant (SmuvicK) was isolated...
  31. pmc Effects of oxygen on virulence traits of Streptococcus mutans
    Sang Joon Ahn
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Bacteriol 189:8519-27. 2007
    Oxygen profoundly affects the composition of oral biofilms. Recently, we showed that exposure of Streptococcus mutans to oxygen strongly inhibits biofilm formation and alters cell surface biogenesis...
  32. ncbi Modifications of hydrophobicity, in vitro adherence and cellular aggregation of Streptococcus mutans by Helichrysum italicum extract
    A Nostro
    Dipartimento Farmaco Biologico, Sezione Microbiologia, Facoltà di Farmacia Università di Messina, Villaggio Annunziata, Italy
    Lett Appl Microbiol 38:423-7. 2004
    The purpose of the present study was to examine whether sublethal concentrations of Helichrysum italicum extract could affect some of the cariogenic properties of Streptococcus mutans.
  33. ncbi The influence of a novel propolis on mutans streptococci biofilms and caries development in rats
    Simone Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
    Arch Oral Biol 51:15-22. 2006
    ..The effects of EEP and EEH on Streptococcus mutans UA159 and Streptococcus sobrinus 6715 biofilms were analysed by time-kill and glycolytic pH drop assays...
  34. pmc Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
    Dragana Ajdic
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 99:14434-9. 2002
    b>Streptococcus mutans is the leading cause of dental caries (tooth decay) worldwide and is considered to be the most cariogenic of all of the oral streptococci. The genome of S...
  35. ncbi The microbiology of primary dental caries in humans
    J M Tanzer
    School of Dental Medicine, University of Connecticut, Farmington 06030 1605, USA
    J Dent Educ 65:1028-37. 2001
    ..Future directions for microbiological clinical caries research are suggested, and the use of the term "caries" to describe the disease, not its lesions, is urged...
  36. ncbi Analysis of CRISPR in Streptococcus mutans suggests frequent occurrence of acquired immunity against infection by M102-like bacteriophages
    Jan R van der Ploeg
    Institute of Oral Biology, University of Zurich, Plattenstrasse 11, CH 8032 Zurich, Switzerland
    Microbiology 155:1966-76. 2009
    ..They can protect bacteria against invasion by foreign DNA elements. The genome sequence of Streptococcus mutans strain UA159 contains two CRISPR loci, designated CRISPR1 and CRISPR2...
  37. ncbi Responses of cariogenic streptococci to environmental stresses
    José A C Lemos
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    Curr Issues Mol Biol 7:95-107. 2005
    ..of biofilm formation, stress tolerance and sugar metabolism by pathogenic oral streptococci, mainly Streptococcus mutans. Overlaps in the roles and regulation of these virulence attributes are highlighted and areas of research ..
  38. pmc Inactivation of VicK affects acid production and acid survival of Streptococcus mutans
    D Senadheera
    Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario M51G6, Canada
    J Bacteriol 191:6415-24. 2009
    The regulation of acid production in and the tolerance to low pH of the cariogenic bacterium Streptococcus mutans have garnered considerable attention since both of these properties contribute substantially to the virulence of this ..
  39. pmc Global transcriptional analysis of Streptococcus mutans sugar transporters using microarrays
    Dragana Ajdic
    University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, 940 S L Young Blvd, Oklahoma City, OK 73104, USA
    J Bacteriol 189:5049-59. 2007
    The transport of carbohydrates by Streptococcus mutans is accomplished by the phosphoenolpyruvate-phosphotransferase system (PTS) and ATP-binding cassette (ABC) transporters. To undertake a global transcriptional analysis of all S...
  40. ncbi Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Antimicrob Chemother 52:782-9. 2003
    Apigenin is a potent inhibitor of glucosyltransferases and tt-farnesol affects the membrane integrity of Streptococcus mutans. We investigated the influence of apigenin and tt-farnesol, alone and in combination, on the accumulation, ..
  41. ncbi Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles
    Sug Joon Ahn
    Dental Research Institute and Department of Orthodontics, College of Dentistry, Seoul National University, 28 22 Yunkeun Dong, ChongRo Ku, Seoul 110 768, Republic of Korea
    Dent Mater 25:206-13. 2009
    ....
  42. pmc Antimicrobial activity against oral pathogens and immunomodulatory effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith
    Silvana A Libério
    Laboratório de Imunofisiologia, Universidade Federal do Maranhao, Av dos Portugueses, sn, CEP 65 080 040, Sao Luis, Maranhao, Brazil
    BMC Complement Altern Med 11:108. 2011
    ..mutans biofilms, and the chemical contents of the extracts. A gel prepared with a geopropolis extract was also analyzed for its activity on S. mutans and its immunotoxicological potential...
  43. pmc Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications
    Joseph M Antonucci
    Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD, USA
    Dent Mater 28:219-28. 2012
    ..Such monomers have the potential to copolymerize with other methacrylate monomers and produce antibacterial polymers...
  44. ncbi Anticariogenic activity of some tropical medicinal plants against Streptococcus mutans
    Jae Kwan Hwang
    Department of Biotechnology and Bioproducts Research Center, Yonsei University, Seoul 120 749, South Korea
    Fitoterapia 75:596-8. 2004
    ..angulata and Quercus infectoria, exhibited potent antibacterial activity against the cariogenic bacterium Streptococcus mutans. In particular, G. glabra, K. pandurata and P...
  45. pmc Subpopulation-specific transcriptome analysis of competence-stimulating-peptide-induced Streptococcus mutans
    André Lemme
    Helmholtz Centre for Infection Research, Research Group Microbial Communication, Braunschweig, Germany
    J Bacteriol 193:1863-77. 2011
    Competence-stimulating-peptide (CSP)-mediated competence development in Streptococcus mutans is a transient and biphasic process, since only a subpopulation induces the expression of ComX in the presence of CSP, and the activation of the ..
  46. pmc Elevated incidence of dental caries in a mouse model of cystic fibrosis
    Marcelo A Catalán
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16549. 2011
    ..of dental cavities requires the colonization of the tooth surface by acid-producing bacteria, such as Streptococcus mutans. Saliva bicarbonate constitutes the main buffering system which neutralizes the pH fall generated by the ..
  47. ncbi luxS-based quorum-sensing signaling affects Biofilm formation in Streptococcus mutans
    Z Huang
    Endodontics Department of Shanghai Ninth People s Hospital affiliated to Medical School, Shanghai Jiao Tong University, Shanghai, China
    J Mol Microbiol Biotechnol 17:12-9. 2009
    ..In this study, we report that luxS-dependent QS is involved in the formation of Streptococcus mutans biofilms.
  48. pmc The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
    Jin Xiao
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Pathog 8:e1002623. 2012
    ..We explored the mechanisms through which the Streptococcus mutans-produced EPS-matrix modulates the three-dimensional (3D) architecture and the population shifts during ..
  49. pmc A 60-kilodalton immunodominant glycoprotein is essential for cell wall integrity and the maintenance of cell shape in Streptococcus mutans
    J S Chia
    Graduate Institute of Microbiology, College of Medicine National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Infect Immun 69:6987-98. 2001
    ..by Western blotting that in naturally sensitized humans, the serum or salivary antibody response to Streptococcus mutans was directed predominantly to a protein antigen with a size of approximately 60-kDa...
  50. ncbi Colony forming unit levels of salivary Lactobacilli and Streptococcus mutans in orthodontic patients
    Ari Kupietzky
    Department of Pediatric Dentistry, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Clin Pediatr Dent 30:51-3. 2005
    The purpose of this study was to compare the levels of Lactobacilli (LB) and Streptococcus mutans (SM) colony forming units (CFU) in the saliva of subjects before and after orthodontic appliance placement...
  51. ncbi Effect of composite resin biodegradation products on oral streptococcal growth
    P Khalichi
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ont, Canada M5S 3G9
    Biomaterials 25:5467-72. 2004
    ..mutans NG8 strain was significantly reduced by MA ( p<0.05 ) above 10mmol/l. In summary, these results indicate that TEG and MA modulate the growth rate of important oral bacteria in a concentration and pH dependent manner...
  52. pmc Role of the dpr product in oxygen tolerance in Streptococcus mutans
    Y Yamamoto
    Laboratory of Applied Microbiology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Amamiya Machi, Aoba ku, Sendai 981 8555, Japan
    J Bacteriol 182:3740-7. 2000
    We have previously identified and characterized the alkyl hydroperoxide reductase of Streptococcus mutans, which consists of two components, Nox-1 and AhpC. Deletion of both nox-1 and ahpC had no effect on the sensitivity of S...
  53. pmc Biofilm formation and virulence expression by Streptococcus mutans are altered when grown in dual-species model
    Zezhang T Wen
    Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
    BMC Microbiol 10:111. 2010
    ..The effects of other species of oral bacteria on biofilm formation and virulence gene expression by Streptococcus mutans, the primary etiologic agent of dental caries, were evaluated using a dual-species biofilm model and ..
  54. ncbi Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms
    Chun Hung Chu
    The University of Hong Kong, China
    Int J Paediatr Dent 22:2-10. 2012
    ..AIM. To characterize the effects of SDF on dentine carious induced by Streptococcus mutans and Actinomyces naeslundii. DESIGN...
  55. pmc Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans
    Jens Kreth
    Department of Diagnostic and Biological Sciences, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, SE, Minneapolis, MN 55455, USA
    J Bacteriol 190:4632-40. 2008
    ..and closely related oral species, Streptococcus gordonii, Streptococcus sanguinis, and cariogenic Streptococcus mutans. S. sanguinis and S...
  56. pmc Development of a 5' nuclease-based real-time PCR assay for quantitative detection of cariogenic dental pathogens Streptococcus mutans and Streptococcus sobrinus
    Akihiro Yoshida
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812 8582, Japan
    J Clin Microbiol 41:4438-41. 2003
    A 5' nuclease TaqMan PCR assay was developed for the quantitative detection of the major cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus. The absolute and relative numbers of bacteria were measured by this method...
  57. ncbi Effect of Psidium cattleianum leaf extract on Streptococcus mutans viability, protein expression and acid production
    F L Brighenti
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    Caries Res 42:148-54. 2008
    ..The aim of this study was to assess the effects of Psidium cattleianum leaf extract on Streptococcus mutans. The extract (100%) was obtained by decoction of 100 g of leaves in 600 ml of deionized water...
  58. ncbi Additive attenuation of virulence and cariogenic potential of Streptococcus mutans by simultaneous inactivation of the ComCDE quorum-sensing system and HK/RR11 two-component regulatory system
    Yung Hua Li
    Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, Canada
    Microbiology 154:3256-65. 2008
    The genome of Streptococcus mutans harbours 13 two-component signal transduction systems (TCSTSs)...
  59. ncbi Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans
    G R Prabu
    CHORD, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, India
    J Appl Microbiol 101:487-95. 2006
    The aim of the present study was to investigate the anti-Streptococcus mutans activity and the in vitro effects of subminimal inhibitory concentrations of guaijaverin isolated from Psidium guajava Linn. on cariogenic properties of Strep...
  60. ncbi Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Microbes Infect 8:114-21. 2006
    b>Streptococcus mutans, a major cariogenic bacterium, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis. Mutant strains of S...
  61. ncbi Isolation and characterization of Streptococcus mutans in heart valve and dental plaque specimens from a patient with infective endocarditis
    Ryota Nomura
    Departments of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Med Microbiol 55:1135-40. 2006
    b>Streptococcus mutans, known to be an aetiologic agent of dental caries, also causes infective endocarditis (IE), although a comparison of isolates from the oral cavity and infected heart valve of the same patient has not been reported...
  62. pmc A eukaryotic-type serine/threonine protein kinase is required for biofilm formation, genetic competence, and acid resistance in Streptococcus mutans
    Haitham Hussain
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    J Bacteriol 188:1628-32. 2006
    ..encoding a eukaryotic-type serine/threonine protein kinase (STPK) and its cognate phosphatase (STPP) in Streptococcus mutans. Mutation of the gene encoding the STPK produced defects in biofilm formation, genetic competence, and acid ..
  63. pmc Streptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation
    Lucja M Jarosz
    Department of Biomedical Engineering, the Kolff Institute, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Eukaryot Cell 8:1658-64. 2009
    ..b>Streptococcus mutans grows in biofilms on enamel surfaces and is considered one of the main etiological agents of human dental ..
  64. ncbi Identification of cariostatic substances in the cacao bean husk: their anti-glucosyltransferase and antibacterial activities
    K Osawa
    Central Laboratory, Lotte Co. Ltd, Saitama, Saitama, Japan
    J Dent Res 80:2000-4. 2001
    ..The latter, which showed bactericidal activity against Streptococcus mutans, were determined to be oleic and linoleic acids, and demonstrated a high level of activity at a ..
  65. pmc The delta subunit of RNA polymerase, RpoE, is a global modulator of Streptococcus mutans environmental adaptation
    Xiaoli Xue
    Research Group Microbial Communication, Division of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    J Bacteriol 192:5081-92. 2010
    ..In this study, we show that inactivation of rpoE in the human dental caries pathogen Streptococcus mutans causes impaired growth and loss of important virulence traits, including biofilm formation, resistance to ..
  66. ncbi Molecular analysis of the inhibitory effects of oolong tea polyphenols on glucan-binding domain of recombinant glucosyltransferases from Streptococcus mutans MT8148
    M Matsumoto
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    FEMS Microbiol Lett 228:73-80. 2003
    ..The effects of OTF6 on the functional domains of GTFs of Streptococcus mutans, an N-terminal catalytic domain (CAT), and a C-terminal glucan-binding domain (GBD), were examined...
  67. pmc Seryl-phosphorylated HPr regulates CcpA-independent carbon catabolite repression in conjunction with PTS permeases in Streptococcus mutans
    Lin Zeng
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Mol Microbiol 75:1145-58. 2010
    Carbohydrate catabolite repression (CCR) in Streptococcus mutans can be independent of catabolite control protein A (CcpA) and requires specific components of phosphoenolpyruvate-dependent sugar:phosphotransferase system (PTS) permeases...
  68. ncbi The science and practice of caries prevention
    J D Featherstone
    Department of Preventive and Restorative Dental Sciences, University of California, San Francisco 94143, USA
    J Am Dent Assoc 131:887-99. 2000
    ..Protective factors--which include salivary calcium, phosphate and proteins, salivary flow, fluoride in saliva, and antibacterial components or agents--can balance, prevent or reverse dental caries...
  69. pmc A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation
    Yung Hua Li
    Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 184:2699-708. 2002
    In a previous study, a quorum-sensing signaling system essential for genetic competence in Streptococcus mutans was identified, characterized, and found to function optimally in biofilms (Li et al., J. Bacteriol. 183:897-908, 2001)...
  70. pmc The Streptococcus mutans Cid and Lrg systems modulate virulence traits in response to multiple environmental signals
    Sang Joon Ahn
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Microbiology 156:3136-47. 2010
    The tight control of autolysis by Streptococcus mutans is critical for proper virulence gene expression and biofilm formation. A pair of dicistronic operons, SMU.575/574 (lrgAB) and SMU...
  71. ncbi Contributions of three glycosyltransferases to sucrose-dependent adherence of Streptococcus mutans
    T Ooshima
    Department of Pedodontics, Osaka University Graduate School of Dentistry, Suita, Japan
    J Dent Res 80:1672-7. 2001
    b>Streptococcus mutans produces 3 types of glucosyltransferase (GTF), whose cooperative action is considered to be essential for its cellular adherence to the tooth surface...
  72. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    ..glucosyltransferases increase the formation of a structurally and metabolically distinctive biofilm by Streptococcus mutans. This host-pathogen-diet interaction may modulate the formation of pathogenic biofilms related to dental ..
  73. pmc CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans
    Jacqueline Abranches
    Department of Oral Biology, University of Florida College of Dentistry, P O Box 100424, Gainesville, FL 32610, USA
    J Bacteriol 190:2340-9. 2008
    ..transcription in response to carbohydrate availability in many gram-positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan hydrolase (fruA) gene of S...
  74. pmc Regulation of bacteriocin production in Streptococcus mutans by the quorum-sensing system required for development of genetic competence
    Jan R van der Ploeg
    Institute for Oral Biology, Center for Dental, Oral Medicine and Maxillofacial Surgery, University of Zurich, Plattenstrasse 11, CH 8032, Zurich, Switzerland
    J Bacteriol 187:3980-9. 2005
    In Streptococcus mutans, competence for genetic transformation and biofilm formation are dependent on the two-component signal transduction system ComDE together with the inducer peptide pheromone competence-stimulating peptide (CSP) (..
  75. pmc Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159
    Ann R Griswold
    Department of Oral Biology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
    J Bacteriol 188:834-41. 2006
    We previously demonstrated that Streptococcus mutans expresses a functional agmatine deiminase system (AgDS) encoded by the agmatine-inducible aguBDAC operon (A. R. Griswold, Y. Y. Chen, and R. A. Burne, J. Bacteriol. 186:1902-1904, 2004)...
  76. pmc Cloning and characterization of an alpha-enolase of the oral pathogen Streptococcus mutans that binds human plasminogen
    Micheala N Jones
    Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 364:924-9. 2007
    b>Streptococcus mutans is the etiologic agent of dental caries and is a causative agent of infective endocarditis. While the mechanisms by which S...
  77. pmc Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence
    Julie A Perry
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    Mol Microbiol 72:905-17. 2009
    ..expression of the peptide pheromone competence-stimulating peptide (CSP) in the oral pathogen Streptococcus mutans. We showed that CSP is involved in the stress response and determined the CSP-induced regulon in S...
  78. pmc The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans
    Prashanth Suntharalingam
    Dental Research Institute, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G1G6, Canada
    J Bacteriol 191:2973-84. 2009
    ..b>Streptococcus mutans, a major etiological agent of dental caries, uses two-component signal transduction systems (TCSTSs) to ..
  79. ncbi Glucan-binding proteins of the oral streptococci
    J A Banas
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Crit Rev Oral Biol Med 14:89-99. 2003
    ..Future studies will greatly advance the understanding of the distribution, function, and regulation of the GBPs and place into perspective the facets of their contributions to the biology of the oral streptococci...
  80. ncbi Quorum sensing and biofilm formation by Streptococcus mutans
    Dilani Senadheera
    Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    Adv Exp Med Biol 631:178-88. 2008
    b>Streptococcus mutans is the primary causative agent involved in dental caries in humans...
  81. pmc Multiple two-component systems of Streptococcus mutans regulate agmatine deiminase gene expression and stress tolerance
    Yaling Liu
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Bacteriol 191:7363-6. 2009
    Induction of the agmatine deiminase system (AgDS) of Streptococcus mutans requires agmatine and is optimal at low pH...
  82. ncbi Effect of a new variety of Apis mellifera propolis on mutans Streptococci
    H Koo
    Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, Caixa Postal 52, Piracicaba, 13414 900, SP, Brazil
    Curr Microbiol 41:192-6. 2000
    ..minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of EEPs against Streptococcus mutans, S. sobrinus, and S. cricetus were determined. Cell adherence of S. mutans and S...
  83. ncbi Chemical composition and biological activity of a new type of Brazilian propolis: red propolis
    S M Alencar
    Department of Agri Food industry, Food and Nutrition, Luiz de Queiroz College of Agriculture, University of Sao Paulo, Avenida Pádua Dias 11, Piracicaba, CEP 13418 900, SP, Brazil
    J Ethnopharmacol 113:278-83. 2007
    ..Our results showed that the red propolis has biologically active compounds that had never been reported in other types of Brazilian propolis...
  84. pmc Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans
    Yung Hua Li
    Dental Research Institute, University of Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 184:6333-42. 2002
    The abilities of Streptococcus mutans to form biofilms and to survive acidic pH are regarded as two important virulence determinants in the pathogenesis of dental caries...
  85. ncbi Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors
    A J Ahola
    Division of Nutrition, University of Helsinki, Helsinki, Finland
    Arch Oral Biol 47:799-804. 2002
    ..Stimulated salivary secretion rates, buffer capacity and counts of salivary Streptococcus mutans, yeast and lactobacilli were evaluated before and after the intervention and after a 3 week post-treatment ..
  86. ncbi Three gene products govern (p)ppGpp production by Streptococcus mutans
    JOSE A LEMOS
    Department of Oral Biology, University of Florida College of Dentistry, PO Box 100424, Gainesville, FL 32610, USA
    Mol Microbiol 65:1568-81. 2007
    ..the sole enzyme controlling (p)ppGpp production and degradation in Gram-positive bacteria does not apply to Streptococcus mutans. We have now identified and characterized two genes, designated as relP and relQ, encoding novel enzymes ..
  87. ncbi Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases
    Moshe Shemesh
    Institute of Dental Sciences, Faculty of Dentistry, Hebrew University Hadassah, Jerusalem 91120, Israel
    Carbohydr Res 341:2090-7. 2006
    Dental caries is one of the most common infectious diseases that affects humans. Streptococcus mutans, the main pathogenic bacterium associated with dental caries, produces a number of extracellular sucrose-metabolizing enzymes, such as ..
  88. ncbi Inhibitory effects of apple polyphenols and related compounds on cariogenic factors of mutans streptococci
    A Yanagida
    Institute for Production Research and Development, The Nikka Whisky Distilling Co, Ltd, 967 Matsuyama, Masuo, Kashiwa, Chiba, 277 0033 Japan
    J Agric Food Chem 48:5666-71. 2000
    ..This means that APP and ACT might selectively inhibit the bacterial GTF activity under oral conditions...
  89. ncbi Expression of biofilm-associated genes of Streptococcus mutans in response to glucose and sucrose
    Moshe Shemesh
    Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University Hadassah, POB 12272, Jerusalem 91120, Israel
    J Med Microbiol 56:1528-35. 2007
    b>Streptococcus mutans is known as a primary pathogen of dental caries, one of the most common human infectious diseases...
  90. pmc Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity
    Hyun Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antimicrob Agents Chemother 46:1302-9. 2002
    ..cinnamic acid derivatives, and terpenoids, were tested for the ability to inhibit GTFs B, C, and D from Streptococcus mutans and GTF from S. sanguinis (GTF Ss)...
  91. ncbi Secretory immunity in defense against cariogenic mutans streptococci
    M W Russell
    Microbiology, University of Alabama at Birmingham, Ala 35294 2170, USA
    Caries Res 33:4-15. 1999
    ..The oral application of preformed, genetically engineered antibodies to mutans streptococcal antigens also offers new prospects for passive immunization against dental caries...
  92. pmc Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans
    Omar E Cornejo
    Department of Genetics, School of Medicine, Stanford University, USA
    Mol Biol Evol 30:881-93. 2013
    b>Streptococcus mutans is widely recognized as one of the key etiological agents of human dental caries...
  93. pmc Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans
    Cristiane Duque
    Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas UNICAMP, Av Limeira 901, CEP 13414 903 Piracicaba, Sao Paulo, Brazil
    Infect Immun 79:786-96. 2011
    The virulence of the dental caries pathogen Streptococcus mutans relies in part on the sucrose-dependent synthesis of and interaction with glucan, a major component of the extracellular matrix of tooth biofilms...
  94. pmc Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation
    Zezhang T Wen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Infect Immun 73:219-25. 2005
    ..A gene, designated ropA, encoding an apparent trigger factor homologue, was identified in Streptococcus mutans, the primary etiological agent of human dental caries...
  95. ncbi Relationship of quantitative salivary levels of Streptococcus mutans and S. sobrinus in mothers to caries status and colonization of mutans streptococci in plaque in their 2.5-year-old children
    M Kishi
    Department of Preventive Dentistry, School of Dentistry, Iwate Medical University, Morioka, Iwate, Japan
    Community Dent Oral Epidemiol 37:241-9. 2009
    The aim of this study was to assess the relationships of quantitative salivary levels of Streptococcus mutans and S. sobrinus in mothers with the colonization of mutans streptococci (MS) in plaque and caries status in their 2...
  96. ncbi Streptococcus oligofermentans inhibits Streptococcus mutans through conversion of lactic acid into inhibitory H2O2: a possible counteroffensive strategy for interspecies competition
    Huichun Tong
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Microbiol 63:872-80. 2007
    ..b>Streptococcus mutans, a major caries-causing pathogen, is a species which tends to interact competitively with other species in ..
  97. ncbi The two-component system ScnRK of Streptococcus mutans affects hydrogen peroxide resistance and murine macrophage killing
    Pei Min Chen
    Department and Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1, Jen Ai Road Section 1, Taipei 10051, Taiwan, ROC
    Microbes Infect 10:293-301. 2008
    ..b>Streptococcus mutans, an opportunistic IE pathogen, generally does not survive well phagocytic killing in murine macrophage RAW ..
  98. ncbi The antibacterial activity of plant extracts containing polyphenols against Streptococcus mutans
    J Smullen
    Biomedical Sciences Research Institute, University of Salford, Manchester, UK
    Caries Res 41:342-9. 2007
    ..available and 70% aqueous propanone (P70) extracts from plants chosen for polyphenol content on Streptococcus mutans and other bacteria were determined using a standard susceptibility agar dilution technique to investigate ..
  99. ncbi Influence of antibody on the structure of glucans
    Leslie K Kopec
    Center for Oral Biology, University of Rochester, NY 14624, USA
    Caries Res 36:108-15. 2002
    ..The results have implications for the formation and properties of biofilms formed in other environments...
  100. ncbi Novel effect of plant lectins on the inhibition of Streptococcus mutans biofilm formation on saliva-coated surface
    B Islam
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
    J Appl Microbiol 106:1682-9. 2009
    ..caries is caused by the disturbance in oral homeostasis, marked by a notable increase in the population of Streptococcus mutans. Lectins are a group of plant proteins that are capable of recognizing the glycoconjugates present on the ..
  101. ncbi Involvement of antigen I/II surface proteins in Streptococcus mutans and Streptococcus intermedius biofilm formation
    D Pecharki
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Oral Microbiol Immunol 20:366-71. 2005
    Dental diseases are caused by microorganisms organized in biofilms. Streptococcus mutans and Streptococcus intermedius are commensals of the human oral cavity. S. mutans is associated with caries, whereas S...

Research Grants65

  1. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..three isolates each of Escherichia coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida albicans also demonstrate an electricidal effect...
  2. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    ..in 25-30 billion dollars in annual health care costs in the US and is caused by the pathogenic bacterium Streptococcus mutans. A major virulence factor is demineralization of teeth by generation of lactic acid from dietary ..
  3. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    b>Streptococcus mutans is the primary causative agent of dental caries, which remains the most common chronic disease among children and is untreated in up to 30% of adults over 35 yrs-old...
  4. Expression of clp genes in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is considered as the major etiological agent in dental caries. S. mutans is also an important agent of infective endocarditis...
  5. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis and is strongly associated with cardiovascular disease and stroke...
  6. New composite material design based on studies of tooth-composite and microbial i
    J Paul Santerre; Fiscal Year: 2013
    ..Objective: To establish methods for reproducibly measuring gene expression of Streptococcus mutans and Lactobacillus casei in situ after formation of biofilms on resin composite, along the resin-dentin ..
  7. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    Project summary: Streptococcus mutans is the primary cariogen that produces several virulence factors. The long-term goal of the proposed studies is to characterize specific interactions of S...
  8. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans-induced caries formation continues to be a major problem in developed and developing nations which, according to the World Health Organization, impacts 60-90% of children world-..
  9. Functional Amyloid Formation in Streptococcus mutans
    L Jeannine Brady; Fiscal Year: 2013
    ..is the most common infectious disease in the world caused in large part by the Gram-positive bacterium Streptococcus mutans. Associated annual health care costs tens of billions of dollars, and rates of childhood caries in the U.S...
  10. Studies of YlxM of Streptococcus mutans, a newly identified component of the Sign
    MATTHEW LAWRENCE WILLIAMS; Fiscal Year: 2013
    ..b>Streptococcus mutans is a cariogenic oral pathogen whose virulence is determined in large part by its membrane composition...
  11. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Data from clinical and basic research have implicated Streptococcus mutans as the primary microbial etiologic agent of dental caries, one of the most common infectious diseases afflicting humans...
  12. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    Abstract: Streptococcus mutans-induced caries formation continues to be a major problem in developed and developing nations which, according to the World Health Organization, impacts 60-90% of children world-wide (123)...
  13. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..The mutans streptococcal group, represented by Streptococcus mutans and S. sobrinis, are the major causative agents of dental caries...
  14. Mechanism of cellulose synthesis and transport across biological membranes
    Jochen Zimmer; Fiscal Year: 2013
    ..caused by biofilms of Staphylococcus aureus and Streptococcus viridans, and dental plaques are biofilms of Streptococcus mutans and sanguinis on the surface of the teeth...
  15. Development of targeted photodynamic therapy for treatment of dental caries
    Randal Eckert; Fiscal Year: 2010
    ..with a limited number of pathogenic bacteria, including the major etiological agent of dental caries, Streptococcus mutans, which ferments dietary sugars to produce enamel-damaging organic acids. The eradication of S...
  16. Making a quantum leap in plaque research with modern sciences
    Wenyuan Shi; Fiscal Year: 2013
    ..of our previously developed specifically targeted antimicrobial peptides (STAMPs) against cariogenic Streptococcus mutans to shift plaque ecology towards a healthy plaque...
  17. Inhibition of oral bacterial biofilm formation using natural products-inspired or
    NATHANIEL CHARLES CADY; Fiscal Year: 2012
    ..This initial study will focus on three ecologically relevant organisms: Streptococcus mutans, Streptococcus sanguinis and Actinomyces naeslundii. S...
  18. The competence regulon in Streptococcus mutans biofilms
    Dennis G Cvitkovitch; Fiscal Year: 2011
    b>Streptococcus mutans resides in the biofilm of dental plaque where it produces acid from dietary carbohydrate to cause caries. S...
  19. Regulation of Oral Bacteria by Pattern Recognition Receptors
    Naohiro Inohara; Fiscal Year: 2012
    ..Some bacteria are known to be involved in oral diseases;for example, Streptococcus mutans and related species in dental caries and Porphymonas gingivalis in adult periodontitis...
  20. Internalization of S. mutans in vascular endothelial cells
    Ann Progulske-Fox; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans (Sm) has long been recognized as a major pathogen of dental caries, the most common infectious disease in humans...
  21. GENETICALLY ENGINEERED ORAL VACCINES AND CARIES IMMUNITY
    Suzanne M Michalek; Fiscal Year: 2012
    ..vector vaccine expressing the gene encoding the saliva-binding region (SBR) of the adhesion AgI/II of Streptococcus mutans showed that the costimulatory molecules CD80 and CD86 play distinct, as well as redundant roles in ..
  22. Roles of Streptococcus mutans YidC1 and YidC2 in membrane biogenesis
    SARA RASER PALMER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Streptococcus mutans is the etiological agent of dental caries costing billions of dollars annually in associated health care...
  23. Intracellular Invasion by Streptococcus mutans: Significance in Disease
    JOSE A LEMOS; Fiscal Year: 2013
    ..b>Streptococcus mutans, a major etiologic agent of dental caries, is also a leading causative agent of infective endocarditis (IE) ..
  24. High-performance Biocompatible GIC System with Permanent Antibacterial Function
    Dong Xie; Fiscal Year: 2010
    ..Bactericidal testing against Streptococcus mutans will be used as a primary screening tool for Quat's antibacterial evaluation...
  25. Probing oral pathogen interactions in picoliter-scale enclosures
    AIMEE KATHERINE WESSEL; Fiscal Year: 2013
    ..of three species of oral bacteria: Streptococcus gordonii, Aggregatibacter actinomycetemcomitans (Aa), and Streptococcus mutans. S...
  26. Epidemiology of Dental Caries and Immunity in Children
    Noel K Childers; Fiscal Year: 2013
    ..We have identified a finite number of MS strains (Streptococcus mutans) in this high risk population, which can now be followed over time from initial colonization of the oral ..
  27. Microfluidic devices for studying genetic competence in Streptococcus mutans
    STEPHEN JAMES HAGEN; Fiscal Year: 2010
    ..e. dental plaque), for example, the metabolic activity of acid-tolerant bacteria such as Streptococcus mutans generates acid waste products that accumulate near the tooth surface, leading to dental caries...
  28. Characterization of a unique two-component system in streptococci
    Indranil Biswas; Fiscal Year: 2013
    ..In this application, we will use Streptococcus mutans as a model organism to study a novel signaling pathway in bacteria. S...
  29. The irvA-dependent pathway: a link between stress adaptation and virulence
    Justin Merritt; Fiscal Year: 2013
    ..The proposed research aims to investigate the genetic and biochemical mechanisms of gene regulation in Streptococcus mutans through the irvA-dependent pathway...
  30. DISPERSION OF STREPTOCOCCUS MUTANS BIOFILMS BY A NOVEL SMALL MOLECULE
    SANDRA S GARCIA; Fiscal Year: 2013
    ..The etiologic causative agent of dental caries is Streptococcus mutans. Not only can S...
  31. Targeting Oral Biofilms with 2-Aminoimidazole/Triazole Conjugates
    Eva Garland; Fiscal Year: 2010
    ..developed in the Melander Lab and then to screen these compounds to identify those that selectively inhibit Streptococcus mutans biofilms. S...
  32. Targeting Oral Biofilms with 2-Aminoimidazole/Triazole Conjugates
    ANGELA MARIE POLLARD; Fiscal Year: 2013
    ..Dental caries is attributed to the presence of the acidogenic bacterium Streptococcus mutans within biofilms, or plaque, on oral surfaces...
  33. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2012
    ..The extracellular polysaccharides (EPS) are synthesized by microorganisms (Streptococcus mutans, a key contributor) and promote biochemical and structural changes in the matrix enhancing the ..
  34. Proton Sponge Adhesives, Interfacial Milieu: Molecular Structure-Mechanics
    Paulette Spencer; Fiscal Year: 2013
    ..Adhesion of the cariogenic bacterium, Streptococcus mutans, to surfaces in the mouth creates an environment that supports the subsequent attachment and growth of ..
  35. GENE REGULATION AND PHYSIOLOGY OF STREPTOCOCCUS MUTANS
    Robert A Burne; Fiscal Year: 2013
    ..In cases when dietary carbohydrates are provided in excess and the host develops dental caries, Streptococcus mutans and other acid-resistant species emerge as significant constituents of dental biofilms as a direct result ..
  36. Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries
    R MIKE SHIRTCLIFF; Fiscal Year: 2013
    ..potentially synergistic, or potentially antagonistic effects of sodium fluoride and povidone-iodine against Streptococcus mutans using the criteria of Eliopoulos and Moellering; (c) Use a slight modification the Featherstone laboratory ..
  37. SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMS
    Hui Wu; Fiscal Year: 2013
    ..Biofilm formation is crucial for the pathogenesis of dental caries caused by cariogenic bacterium Streptococcus mutans. S. mutans has adapted to the biofilm lifestyle...
  38. TYPE II Enterotoxins as Mucosal Immunomodulators
    Terry D Connell; Fiscal Year: 2010
    ..receptor-binding activities, will be analyzed in a mucosal mouse model using Agl/II of the oral pathogen Streptococcus mutans as a model antigen...
  39. Functional Characterization of the Site Specific Residues in Mutacin 1140
    James Smith; Fiscal Year: 2009
    ..Preliminary characterization of mutacin 1140, an antibiotic made by a strain of Streptococcus mutans, suggests that it holds great promise...
  40. Proof of Concept: Scardovia wiggsiae is Cariogenic in vivo
    Anne C R Tanner; Fiscal Year: 2012
    ..induce tooth demineralization and produce caries in vivo, acting either acting alone or in synergy with Streptococcus mutans. The rationale for this proposal is that proof of cariogenic potential in vivo would justify in- depth ..
  41. BrpA in Virulence Modulation of Streptococcus mutans
    ZEZHANG TOM WEN; Fiscal Year: 2012
    SUMMARY: Streptococcus mutans is the primary etiological agent of dental caries, a costly and ubiquitous health problem worldwide...
  42. The LytTR Regulatory Systems of Streptococcus mutans
    Justin Merritt; Fiscal Year: 2013
    ..by LytTR Regulatory Systems (LRS) as well as explore a cell death pathway triggered by these systems in Streptococcus mutans. LRS are a newly described gene regulatory system that consists of a LytTR family transcription regulator ..
  43. Planning Parental/Motivational Interventions to Prevent Early Childhood Caries
    Mark Steven Wolff; Fiscal Year: 2013
    ..Although ECC is instigated by certain acidogenic and aciduric members of the biofilm (Streptococcus mutans) and is nearly entirely preventable, its intractable (and even rising) prevalence indicates the strong ..
  44. Raman/OCT probe for real-time assessment of oral health status
    Nicusor Iftimia; Fiscal Year: 2013
    ..discriminate between different species of bacteria grown in biofilms, such as Streptococcus sanguinis and Streptococcus mutans, which are major components of the oral plaque, OCT allows for visualizing soft tissue inflammations, as ..
  45. Ser/Thr protein kinase PknB as target to decrease Streptococcus mutans ecological
    Jens Kreth; Fiscal Year: 2013
    ..The role of oral biofilm member Streptococcus mutans in the etiology of dental caries has been well established. Management of S...
  46. Microbial Diversity and Genetic Characterization of Cariogenic Biofilms
    Page W Caufield; Fiscal Year: 2012
    ..anticipated to yield important new information as to the presence of specific genetic determinants found in Streptococcus mutans, a microbe strongly associated with a severe dental caries in affecting young children called severe early ..
  47. REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITY
    Suzanne Michalek; Fiscal Year: 2003
    ..g., teeth. Secretory IgA antibodies in saliva are important in protection against oral diseases, including Streptococcus mutans-induced dental caries, and are induced following stimulation of the common mucosal immune system (CMIS)...
  48. Regulation of Streptococcus mutans PTS Transporters
    Dragana Ajdic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sugar transport and metabolism by Streptococcus mutans is directly related to the onset and development of the biofilm commonly called plaque, leading to the formation of human dental caries (tooth ..
  49. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    ..microbial species together with a limited number of acid- producing (cariogenic) bacteria such as Streptococcus mutans and Lactobacillus species...
  50. MICROBIAL GENOME PROJECT STREPTOCOCCUS MUTANS
    JOSEPH FERRETTI; Fiscal Year: 2000
    ..from the Investigator's Abstract): The investigators propose to determine the complete genome sequence of Streptococcus mutans in this application. Decades of epidemiological, biochemical and animal studies have demonstrated that S...
  51. New Phosphated Polymers Prevent Microbial Colonization
    Andrew Dentino; Fiscal Year: 2009
    ..polymers using Candida albicans, Streptococcus Sanguis, Streptococcus oralis, Streptococcus gordonii and Streptococcus mutans;4) Delineation of the physical and mechanical properties of polymers that exhibit high affinity for ..
  52. BACTERIAL ADHESION TO DENTIN IN ROOT SURFACE CARIES
    LECH SWITALSKI; Fiscal Year: 1993
    ..this disease unclear, however some bacteria are isolated from root caries lesions most often: Lactobacilli, Streptococcus mutans and Actinomyces...
  53. Specificity of Streptococcus mutans sugar transporters
    Dragana Ajdic; Fiscal Year: 2009
    Sugar transport and metabolism by Streptococcus mutans is directly related to the onset and development dental plaque, leading to the formation of human dental caries (tooth decay). In S...
  54. Efficacy of DNA versus Protein Vaccine
    MYLIEN DAO; Fiscal Year: 2004
    Dental caries is an infectious disease caused by Streptococcus mutans. Despite fluoridation and improved Dental hygiene in industrialized countries, worldwide Dental cades is still a significant public health problem affecting 50-90 ..
  55. T CELL REGULATION OF CARIES IMMUNITY/PERIODONTAL DISEASE
    Hiroshi Kiyono; Fiscal Year: 1992
    ..It has also been shown that oral administration of Streptococcus mutans vaccine to human induces antigen-specific secretory IgA (S-IgA) responses in mucosal associated secretions ..
  56. Stationary Phase Behavior in Oral Streptococci
    PATRICK PIGGOT; Fiscal Year: 2006
    DESCRIPTION: Streptococcus mutans is the primary agent of Dental caries. We think that stationary-phase bacteria are critical to the behavior and survival of S. mutans in the Dental plaque biofilm, and hence to its role in Dental caries...
  57. S MUTANTS GLG GENE EXPRESSION
    Grace Spatafora; Fiscal Year: 2001
    DESCRIPTION (Adapted from investigator's Abstract): Streptococcus mutans, the principal etiologic agent of dental caries in humans, infects more than 95% of the population worldwide, often colonizing the oral cavity during the first year ..
  58. LuxS-Mediated Quorum Sensing in Streptococcus mutans
    ZEZHANG WEN; Fiscal Year: 2004
    b>Streptococcus mutans is recognized as the principal etiological agent of dental caries, the most prevalent infectious disease of humans...
  59. COORDINATION OF S MUTANS SUCROSE METABOLISM
    Lin Tao; Fiscal Year: 2001
    This is a revised R29 application. Streptococcus mutans cariogenicity is associated with its sucrose metabolism via multiple pathways, among which some make sugar polymers for colonization and energy storage, while others produce acid ..
  60. LYSIS OF CARIOGENIC BACTERIA BY PHAGE-ENCODED ENZYMES
    ALLAN DELISLE; Fiscal Year: 2002
    ..is to develop species-specific, cell wall-hydrolyzing enzymes encoded in the genomes of phages specific for Streptococcus mutans and Actinomyces naeslundii as new therapeutic treatments for dental caries. S...
  61. Genetic and biochemical studies of competence regulation by the hdrRM operon
    Justin Merritt; Fiscal Year: 2009
    ..proposed research Aims to investigate the genetic and biochemical mechanisms of competence regulation in Streptococcus mutans by the newly discovered high cell density responsive hdrRM operon...
  62. Cloning Analysis of S. mutans Putative Collagenase
    MYLIEN DAO; Fiscal Year: 2004
    ..b>Streptococcus mutans, an etiologic agent in the development of coronal caries, has also been implicated in Dental root decay; ..
  63. Muscosal Immunity in Heavily S. Mutans Exposed Children
    Daniel Smith; Fiscal Year: 2005
    ..infectious disease is still a worldwide public health problem, affecting mainly populations under high Streptococcus mutans challenge...
  64. GENE REGULATION IN THE ORAL STREPTOCOCCI
    Ronald Yasbin; Fiscal Year: 1991
    ..production, acidogenesis, and acidurance are virulence properties associated with the cariogenic bacterium Streptococcus mutans. Each of these properties contributes to some degree to the virulence of this organism...
  65. STREPTOCOCCUS MUTANS GENES IMPORTANT TO VIRULENCE
    Michael Hudson; Fiscal Year: 1992
    ..long-term objective of the proposed research is to investigate the potential regulation of expression of Streptococcus mutans genes which are important to virulence and the induction of dental caries...