streptococcus pyogenes

Summary

Summary: A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.

Top Publications

  1. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
  2. pmc Multiplex genome engineering using CRISPR/Cas systems
    Le Cong
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 339:819-23. 2013
  3. ncbi Molecular insight into invasive group A streptococcal disease
    Jason N Cole
    Department of Pediatrics, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, 92093 0687, USA
    Nat Rev Microbiol 9:724-36. 2011
  4. ncbi Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    Seung Woo Cho
    National Creative Research Initiatives Center for Genome Engineering, Seoul National University, Seoul, South Korea
    Nat Biotechnol 31:230-2. 2013
  5. pmc M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition
    Xavier Lauth
    Department of Pediatrics, University of California San Diego, La Jolla, Calif 92093 0687, USA
    J Innate Immun 1:202-14. 2009
  6. pmc The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript
    Esmeralda Ramirez-Peña
    Department of Pathology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Microbiol 78:1332-47. 2010
  7. ncbi Innate antimicrobial peptide protects the skin from invasive bacterial infection
    V Nizet
    Department of Pediatrics, University of California, San Diego, California 92161, USA
    Nature 414:454-7. 2001
  8. pmc Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
    Jurgen Harder
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 183:5823-9. 2009
  9. pmc Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes
    W Michael McShan
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, CPB307, Oklahoma City, OK, USA
    J Bacteriol 190:7773-85. 2008
  10. ncbi Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria
    Aleksandr Barinov
    INRA Génétique Microbienne, Domaine de Vilvert, Jouy en Josas, France
    Proteomics 9:61-73. 2009

Detail Information

Publications370 found, 100 shown here

  1. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
    ..On a global scale, GAS is an important cause of morbidity and mortality. These data emphasise the need to reinforce current control strategies, develop new primary prevention strategies, and collect better data from developing countries...
  2. pmc Multiplex genome engineering using CRISPR/Cas systems
    Le Cong
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 339:819-23. 2013
    ....
  3. ncbi Molecular insight into invasive group A streptococcal disease
    Jason N Cole
    Department of Pediatrics, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, 92093 0687, USA
    Nat Rev Microbiol 9:724-36. 2011
    b>Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide...
  4. ncbi Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    Seung Woo Cho
    National Creative Research Initiatives Center for Genome Engineering, Seoul National University, Seoul, South Korea
    Nat Biotechnol 31:230-2. 2013
    We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in human cells...
  5. pmc M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition
    Xavier Lauth
    Department of Pediatrics, University of California San Diego, La Jolla, Calif 92093 0687, USA
    J Innate Immun 1:202-14. 2009
    ..We conclude increased resistance to host cathelicidin and killing within phagocyte extracellular traps contribute to the propensity of M1 GAS strains to produce invasive infections...
  6. pmc The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript
    Esmeralda Ramirez-Peña
    Department of Pathology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Microbiol 78:1332-47. 2010
    ..Our data provide new insights into the mechanisms used by small regulatory RNAs to activate target mRNAs, and enhances our understanding of the regulation of a key GAS virulence factor...
  7. ncbi Innate antimicrobial peptide protects the skin from invasive bacterial infection
    V Nizet
    Department of Pediatrics, University of California, San Diego, California 92161, USA
    Nature 414:454-7. 2001
    ..Here we show that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS)...
  8. pmc Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
    Jurgen Harder
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 183:5823-9. 2009
    Macrophages play a crucial role in the innate immune response against the human pathogen Streptococcus pyogenes, yet the innate immune response against the bacterium is poorly characterized...
  9. pmc Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes
    W Michael McShan
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, CPB307, Oklahoma City, OK, USA
    J Bacteriol 190:7773-85. 2008
    The 1,815,783-bp genome of a serotype M49 strain of Streptococcus pyogenes (group A streptococcus [GAS]), strain NZ131, has been determined...
  10. ncbi Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria
    Aleksandr Barinov
    INRA Génétique Microbienne, Domaine de Vilvert, Jouy en Josas, France
    Proteomics 9:61-73. 2009
    ..of potentially surface exposed (PSE) proteins from Gram-positive bacteria, which was validated for Streptococcus pyogenes. The results of an exploratory case study on closely related lactobacilli of the acidophilus group suggest ..
  11. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  12. ncbi Global emm type distribution of group A streptococci: systematic review and implications for vaccine development
    Andrew C Steer
    Centre for International Child Health, University of Melbourne, Australia
    Lancet Infect Dis 9:611-6. 2009
    ....
  13. ncbi The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes
    Jason W Rosch
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, St Louis, MO 63110 1093, USA
    Mol Microbiol 58:959-68. 2005
    The Gram-positive pathogen Streptococcus pyogenes secretes proteins through the ExPortal, a unique single microdomain of the cellular membrane specialized to contain the Sec translocons...
  14. pmc Contribution of exogenous genetic elements to the group A Streptococcus metagenome
    Stephen B Beres
    Center for Molecular and Translational Human Infectious Diseases Research, Methodist Hospital Research Institute, Houston, Texas, United States of America
    PLoS ONE 2:e800. 2007
    ..The data provide new information about the GAS metagenome and will assist studies of pathogenesis, antimicrobial resistance, and population genomics...
  15. ncbi Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule
    B Kreikemeyer
    Department of Medical Microbiology and Hygiene, University Hospital Ulm, Robert-Koch-Str. 8, D-89081 Ulm, Germany
    Mol Microbiol 39:392-406. 2001
    ..regulator, Fas (fibronectin/fibrinogen binding/haemolytic activity/streptokinase regulator), of Streptococcus pyogenes was identified in the M1 genome sequence, based on homologies to the histidine protein kinase (HPK) and ..
  16. ncbi DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps
    John T Buchanan
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 16:396-400. 2006
    ..The results demonstrate a significant role for NETs in neutrophil-mediated innate immunity, and at the same time identify a novel therapeutic target against invasive GAS infection...
  17. pmc M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment
    Laura E Crotty Alexander
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Mol Med (Berl) 88:371-81. 2010
    ....
  18. ncbi The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004
    Rosalyn E O'Loughlin
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 45:853-62. 2007
    ..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine...
  19. pmc Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence
    Ramy K Aziz
    Research Services, Veterans Affairs Medical Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e9798. 2010
    ..Having previously reported that M1T1 Streptococcus pyogenes become hypervirulent in mice due to selection of mutants in the covRS regulatory genes, we set out to ..
  20. pmc Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates
    Tadayoshi Ikebe
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS Pathog 6:e1000832. 2010
    ..mutations of csrS/csrR genes, a two-component negative regulator system for multiple virulence genes of Streptococcus pyogenes, are found among the isolates from STSS patients...
  21. ncbi Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections
    Linda Johansson
    Karolinska Institutet, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Infect Dis 51:58-65. 2010
    b>Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue ..
  22. pmc Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection
    Nina Gratz
    Max F Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
    PLoS Pathog 7:e1001345. 2011
    b>Streptococcus pyogenes is a Gram-positive human pathogen that is recognized by yet unknown pattern recognition receptors (PRRs). Engagement of these receptor molecules during infection with S...
  23. pmc Hydrogen peroxide production in Streptococcus pyogenes: involvement of lactate oxidase and coupling with aerobic utilization of lactate
    Masanori Seki
    Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Bacteriol 186:2046-51. 2004
    b>Streptococcus pyogenes strains can be divided into two classes, one capable and the other incapable of producing H2O2 (M. Saito, S. Ohga, M. Endoh, H. Nakayama, Y. Mizunoe, T. Hara, and S. Yoshida, Microbiology 147:2469-2477, 2001)...
  24. pmc Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
    Chih Feng Kuo
    Department of Nursing, I Shou University, Kaohsiung County, Taiwan
    Infect Immun 76:1163-9. 2008
    ..These results suggest a novel SPE B mechanism, one which degrades serum C3 and enables GAS to resist complement damage and opsonophagocytosis...
  25. pmc Virulence gene regulation by CvfA, a putative RNase: the CvfA-enolase complex in Streptococcus pyogenes links nutritional stress, growth-phase control, and virulence gene expression
    Song Ok Kang
    Department of Microbiology, Southern Illinois University Carbondale, Carbondale, Illinois 62901 6508, USA
    Infect Immun 78:2754-67. 2010
    b>Streptococcus pyogenes, a multiple-auxotrophic human pathogen, regulates virulence gene expression according to nutritional availability during various stages in the infection process or in different infection sites...
  26. pmc Streptococcal M1 protein constructs a pathological host fibrinogen network
    Pauline Macheboeuf
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Nature 472:64-8. 2011
    ..Disruption of this network into other supramolecular assemblies was not tolerated. These results have bearing on the pathophysiology of streptococcal toxic shock...
  27. pmc A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection
    Samuel A Shelburne
    Department of Infectious Diseases, MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS Pathog 6:e1000817. 2010
    ..These data provide new knowledge regarding the molecular mechanisms by which pathogenic bacteria respond to environmental signals to regulate virulence factor production and basic metabolic processes during infection...
  28. ncbi In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system
    Ana G Camacho
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, C S I C, E 28049 Madrid, Spain
    Biol Chem 383:1701-13. 2002
    b>Streptococcus pyogenes pSM19035-encoded epsilon (10.7 kDa) and zeta (32...
  29. ncbi Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice
    Oliver Goldmann
    Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Center for Biotechnology, Braunschweig, Germany
    J Infect Dis 191:1280-6. 2005
    ..In the present study, the relative contribution of NK cells to the development of Streptococcus pyogenes-induced septic shock was investigated in a mouse model of group A streptococcal infection that resembles ..
  30. pmc Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB)
    Christopher D Doern
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Microbiology 155:46-52. 2009
    ..Complementation of MGAS5005Deltasrv restored the biofilm phenotype and eliminated the overproduction of active SpeB. Inhibition of SpeB with E64 also restored the MGAS5005Deltasrv biofilm to wild-type levels...
  31. pmc Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes
    Harry S Courtney
    Department of Medicine, University of Tennessee, Memphis, Tennessee, United States of America
    PLoS ONE 4:e4166. 2009
    ..Hydrophobicity of Streptococcus pyogenes is primarily due to lipoteichoic acid (LTA) on the streptococcal surface but the mechanism(s) whereby LTA ..
  32. pmc Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens
    Matthew T G Holden
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 5:e1000346. 2009
    ..These pathogens share approximately 80% genome sequence identity with the important human pathogen Streptococcus pyogenes. We sequenced and compared the genomes of S. equi 4047 and S. zooepidemicus H70 and screened S. equi and S...
  33. pmc Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring
    Vinzenz Lange
    Institute of Molecular Systems Biology, ETH Zurich, Zurich 8093, Switzerland
    Mol Cell Proteomics 7:1489-500. 2008
    ..we were able to reliably quantify low abundance virulence factors from cultures of the human pathogen Streptococcus pyogenes exposed to increasing amounts of plasma...
  34. pmc Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes
    Ramy K Aziz
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis 38163, USA
    J Bacteriol 187:3311-8. 2005
    ..Y, replacing it with a different module identical to that found on a related M3 phage. Taken together, the data demonstrate that mosaicism of the GAS prophages has contributed to the emergence and diversification of the M1T1 subclone...
  35. ncbi Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection
    N C Engleberg
    Departments of Internal Medicine and Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Infect Dis 183:1043-54. 2001
    CsrS/CsrR is a 2-component system in Streptococcus pyogenes that negatively regulates hyaluronic capsule and several exotoxins...
  36. pmc Discovery of a widely distributed toxin biosynthetic gene cluster
    Shaun W Lee
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:5879-84. 2008
    ..Using the toxin precursor peptide and heterocycle-forming synthetase proteins from the human pathogen Streptococcus pyogenes, we demonstrate the in vitro reconstitution of streptolysin S activity...
  37. ncbi Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens
    Marta Bober
    Division of Infection Medicine, Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden
    J Innate Immun 2:160-6. 2010
    ..Here we describe collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae...
  38. pmc Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics
    Stephen B Beres
    Department of Pathology, The Methodist Hospital, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:4371-6. 2010
    ..We conclude that enhanced understanding of bacterial epidemics requires a deep-sequencing, geographically centric, comparative pathogenomics strategy...
  39. ncbi Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure
    Hae Joo Kang
    Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand
    Science 318:1625-8. 2007
    ..The crystal structure of the major pilin subunit from the Gram-positive human pathogen Streptococcus pyogenes at 2.2 angstroms resolution reveals an extended structure comprising two all-beta domains...
  40. pmc The validity of a sore throat score in family practice
    W J McIsaac
    Family Medicine Centre, Mount Sinai Hospital, Toronto, Ont
    CMAJ 163:811-5. 2000
    ..The study also examined the potential impact of this clinical score on the prescribing of antibiotics in community-based family practice...
  41. ncbi Autophagy defends cells against invading group A Streptococcus
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Science 306:1037-40. 2004
    ..In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens...
  42. pmc Complete genome sequence of an M1 strain of Streptococcus pyogenes
    J J Ferretti
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Proc Natl Acad Sci U S A 98:4658-63. 2001
    The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes, a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes...
  43. pmc Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes
    J A Carriço
    Grupo de Biomatemática, Istituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6 2780 156 Oeiras, Portugal
    J Clin Microbiol 44:2524-32. 2006
    ..A collection of 325 macrolide-resistant Streptococcus pyogenes isolates associated with pharyngitis cases in Portugal was used to benchmark the proposed measures...
  44. ncbi Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  45. pmc Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
    Bogdan Luca-Harari
    Department of Clinical Microbiology and Immunology, Lund University Hospital USIL, Lund, Sweden
    J Clin Microbiol 47:1155-65. 2009
    In an attempt to compare the epidemiology of severe Streptococcus pyogenes infection within Europe, prospective data were collected through the Strep-EURO program. Surveillance for severe cases of S...
  46. pmc Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation
    Florencia Pratto
    Department of Microbial Biotechnology, National Centre of Biotechnology, CSIC, 28049 Madrid, Spain
    Nucleic Acids Res 36:3676-89. 2008
    ....
  47. pmc Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapies
    H Sun
    Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA
    J Thromb Haemost 9:189-94. 2011
    ....
  48. pmc Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    Lei S Qi
    UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 152:1173-83. 2013
    ..We also show evidence that the system can be adapted for gene repression in mammalian cells. This RNA-guided DNA recognition platform provides a simple approach for selectively perturbing gene expression on a genome-wide scale...
  49. pmc Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice
    Hongmin Sun
    Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:3469-74. 2012
    ..These data suggest that the class of compounds represented by CCG-2979 may be of therapeutic value for the treatment of GAS and potentially other gram-positive infections in humans...
  50. pmc Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine
    Andrea Fritzer
    Intercell AG, Campus Vienna Biocenter 3, 1030 Vienna, Austria
    Infect Immun 78:4051-67. 2010
    ..Although antibiotic treatment is very effective, when left untreated, Streptococcus pyogenes infections can lead to poststreptococcal sequelae and severe disease causing significant morbidity and ..
  51. pmc Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing
    Nikolai Siemens
    Institute of Medical Microbiology, Virology and Hygiene, Rostock University Hospital, Schillingallee 70, 18057 Rostock, Germany
    J Biol Chem 286:21612-22. 2011
    ..responses are a prerequisite for a successful colonization and subsequent infection of the human host by Streptococcus pyogenes (group A streptococci, GAS)...
  52. ncbi The Hypervariable region of Streptococcus pyogenes M protein escapes antibody attack by antigenic variation and weak immunogenicity
    Jonas Lannergård
    Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Sweden
    Cell Host Microbe 10:147-57. 2011
    ..of antibody evasion, we analyzed the clinically important HVR-containing M proteins of the human pathogen Streptococcus pyogenes. Antibodies elicited by M proteins were directed almost exclusively against the C-terminal part and not ..
  53. ncbi The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications
    Dwight R Johnson
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Clin Infect Dis 50:481-90. 2010
    ..Although the importance of immunologic confirmation of infection is widely accepted, the immediate and long-term immunokinetics of the human antibody response are incompletely documented and poorly understood...
  54. ncbi From transcription to activation: how group A streptococcus, the flesh-eating pathogen, regulates SpeB cysteine protease production
    Ronan K Carroll
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mol Microbiol 81:588-601. 2011
    ..Here we review the molecular aspects of SpeB production by GAS from transcription to activation and the multiple layers of control involved...
  55. ncbi Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics
    Surasak Limsuwan
    Faculty of Traditional Thai Medicine and Natural Products Research Center, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Phytomedicine 18:934-40. 2011
    ..leaf extract has a strong antibacterial activity against the bacterial pathogen Streptococcus pyogenes. Our previous studies indicated that the bactericidal activity of rhodomyrtone might involve intracellular ..
  56. pmc Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence
    Johan Waldemarsson
    Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Lund, Sweden
    PLoS ONE 4:e7279. 2009
    The surface-localized M protein of Streptococcus pyogenes is a major virulence factor that inhibits phagocytosis, as determined ex vivo...
  57. ncbi The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains
    Martina L Sanderson-Smith
    School of Biological Sciences, University of Wollongong, Northfields Avenue, New South Wales 2522, Australia
    J Biol Chem 281:25965-71. 2006
    ....
  58. ncbi Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes
    Oliver Goldmann
    Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 185:2372-81. 2010
    b>Streptococcus pyogenes is a significant human pathogen that can cause life-threatening invasive infections. Understanding the mechanism of disease is crucial to the development of more effective therapies...
  59. pmc Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells
    C F Kuo
    Department of Microbiology, National Cheng Kung University Medical College, Taiwan, Republic of China
    Infect Immun 67:126-30. 1999
    Treatment of U937 human monocyte-like cells with Streptococcus pyogenes led to an induction of apoptosis in these cells...
  60. pmc Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal
    Renato Pires
    Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica, Portugal
    Antimicrob Agents Chemother 54:2677-80. 2010
    We describe 66 ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the emm6/sequence type 382 (emm6/ST382) lineage...
  61. pmc The ancillary protein 1 of Streptococcus pyogenes FCT-1 pili mediates cell adhesion and biofilm formation through heterophilic as well as homophilic interactions
    Marco Becherelli
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena, Italy
    Mol Microbiol 83:1035-47. 2012
    ..present study we undertook the functional characterization of the pilus ancillary protein 1 (AP1_M6) from Streptococcus pyogenes isolates expressing the FCT-1 pilus variant, known to be strong biofilm formers...
  62. ncbi Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000
    Nick Daneman
    University of Toronto, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Intern Med 147:234-41. 2007
    b>Streptococcus pyogenes can cause severe disease in the individual patient and dramatic hospital outbreaks.
  63. pmc New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci
    James B Dale
    Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Vaccine 29:8175-8. 2011
    ..These results indicate that the potential efficacy of the new multivalent vaccine may be greater than predicted based on the "type-specific" M peptides represented...
  64. ncbi Burden of acute sore throat and group A streptococcal pharyngitis in school-aged children and their families in Australia
    Margaret H Danchin
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatrics 120:950-7. 2007
    ..The objective of this study was to determine the incidence, transmission, carriage, and risk factors for group A streptococcal pharyngitis in school-aged children and their families...
  65. ncbi A new rapid and cost-effective method for detection of phages, ICEs and virulence factors encoded by Streptococcus pyogenes
    Anna L Borek
    Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland
    Pol J Microbiol 60:187-201. 2011
    b>Streptococcus pyogenes (group A Streptococcus, GAS) is a human pathogen that causes diseases of various intensity, from mild strep throat to life threatening invasive infections and postinfectional sequelae. S...
  66. pmc Streptococcus pyogenes in human plasma: adaptive mechanisms analyzed by mass spectrometry-based proteomics
    Johan Malmstrom
    Department of Immunotechnology, Lund University, SE 22100 Lund, Sweden
    J Biol Chem 287:1415-25. 2012
    b>Streptococcus pyogenes is a major bacterial pathogen and a potent inducer of inflammation causing plasma leakage at the site of infection...
  67. pmc Crystal structure of Streptococcus pyogenes Csn2 reveals calcium-dependent conformational changes in its tertiary and quaternary structure
    Yoon Koo
    Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    PLoS ONE 7:e33401. 2012
    ..Here, we report a 2.2 Å crystal structure of Streptococcus pyogenes Csn2...
  68. pmc Environmental acidification drives S. pyogenes pilus expression and microcolony formation on epithelial cells in a FCT-dependent manner
    Andrea G O Manetti
    Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 5:e13864. 2010
    Group A Streptococcus (GAS, Streptococcus pyogenes) is a gram-positive human pathogen responsible for a diverse variety of diseases, including pharyngitis, skin infections, invasive necrotizing fasciitis and autoimmune sequelae...
  69. pmc Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes
    C H Jones
    SIGA Research Laboratories, SIGA Technologies, Inc, Corvallis, Oregon 97333, USA
    Infect Immun 69:5538-45. 2001
    ..coli pilus biogenesis. We report here the identification of highly homologous enzymes in Streptococcus pyogenes, Streptococcus gordonii, Streptococcus mutans, Staphylococcus aureus, and Enterococcus faecalis...
  70. ncbi Proteomic analysis of proteins secreted by Streptococcus pyogenes
    Michelle A Chaussee
    Division of Basic Biomedical Sciences, The Stanford School of Medicine of the University of South Dakota, Vermillion, SD, USA
    Methods Mol Biol 431:15-24. 2008
    b>Streptococcus pyogenes secretes various proteins to the extracellular environment. During infection, these proteins interact with human macromolecules and contribute to pathogenesis...
  71. ncbi Streptococcal M proteins and their role as virulence determinants
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, SE 22184 Lund, Sweden
    Clin Chim Acta 411:1172-80. 2010
    Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades...
  72. pmc DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition
    Satoshi Uchiyama
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    PLoS Pathog 8:e1002736. 2012
    ..Our results demonstrate a novel mechanism of bacterial innate immune evasion based on autodegradation of CpG-rich DNA by a bacterial DNase...
  73. ncbi Macrolide resistance in Streptococcus pyogenes: prevalence, resistance determinants, and emm types
    Athanasios G Michos
    First Department of Pediatrics, Aghia Sophia Children s Hospital, Athens University, Greece
    Diagn Microbiol Infect Dis 64:295-9. 2009
    ..8%), 12 (17.5%), 28 (13.8%). The observed antimicrobial resistance trends and the distribution of specific emm types have implications in guiding empiric therapy and in developing vaccine strategies to prevent GAS infections...
  74. pmc Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development
    Jennifer C Chang
    Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 7:e1002190. 2011
    b>Streptococcus pyogenes (Group A Streptococcus, GAS) is an important human commensal that occasionally causes localized infections and less frequently causes severe invasive disease with high mortality rates...
  75. ncbi Diagnosis and treatment of streptococcal pharyngitis
    Beth A Choby
    Department of Family Medicine, University of Tennessee College of Medicine Chattanooga, UT Family Practice Center, 37403, USA
    Am Fam Physician 79:383-90. 2009
    ..Whether tonsillectomy or adenoidectomy decreases the incidence of GABHS pharyngitis is poorly understood. At this time, the benefits are too small to outweigh the associated costs and surgical risks...
  76. ncbi Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases
    S E Swedo
    Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
    Am J Psychiatry 155:264-71. 1998
    ....
  77. ncbi Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions
    Bernd Kreikemeyer
    University Hospital Rostock, Department of Medical Microbiology and Hospital Hygiene, Schillingallee 70, 18055 Rostock, Germany
    Trends Microbiol 11:224-32. 2003
    b>Streptococcus pyogenes (group A streptococcus, GAS) is a very important human pathogen with remarkable adaptation capabilities...
  78. ncbi Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes
    Kyu Hong Cho
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, St Louis, MO 63110 1093, USA
    Mol Microbiol 57:1545-56. 2005
    The ability of Streptococcus pyogenes to form biofilm-like bacterial communities during infection of soft tissue has suggested that the capacity to produce biofilm may be important for pathogenesis...
  79. pmc Biofilm formation by group a streptococci: is there a relationship with treatment failure?
    Joslyn Conley
    Department of Community Health Sciences, University of Calgary, Calgary, Canada
    J Clin Microbiol 41:4043-8. 2003
    ..In addition, further investigations are necessary to determine if non-biofilm-forming strains of GAS exist and the roles of in vivo monospecies and multispecies biofilms in streptococcal pharyngitis treatment failure...
  80. ncbi Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events
    Paul Sumby
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 192:771-82. 2005
    ..Multiple horizontal gene transfer events were a crucial factor in the evolutionary origin and emergence of a very abundant contemporary clone of serotype M1 GAS...
  81. ncbi A vaccine against S. pyogenes: design and experimental immune response
    L Guilherme
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Brazil
    Methods 49:316-21. 2009
    b>Streptococcus pyogenes causes severe invasive infections: the post-streptococcal sequelae of acute rheumatic fever (RF) and rheumatic heart disease (RHD), acute glomerulonephritis, and uncomplicated pharyngitis and pyoderma...
  82. pmc Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection
    Beinan Wang
    Department of Microbiology, and Discovery Genomics, Inc, Minneapolis, MN 55413, USA
    Proc Natl Acad Sci U S A 107:5937-42. 2010
    ..The association of a Th17 response with GAS infection reveals a potential mechanism for destructive autoimmune responses in humans...
  83. pmc Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly
    Hae Joo Kang
    Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    PLoS ONE 6:e15969. 2011
    ..The sortase Spy0129, or SrtC1, from the M1 SF370 strain of Streptococcus pyogenes is responsible for generating the covalent linkages between the pilin subunits in the pili of this ..
  84. ncbi Distribution of emm types and subtypes among noninvasive group A, C and G streptococcal isolates in western Norway
    Bård Reiakvam Kittang
    Department of Medicine, Haukeland University Hospital, University of Bergen, Bergen, Norway
    APMIS 116:457-64. 2008
    ..4% of the GCS and GGS isolates. The high proportion of skin isolates in the present study may indicate the existence of GAS, GCS and GGS strains with predominantly skin and soft tissue tropism in our community...
  85. pmc Comparative analysis of emm type pattern of Group A Streptococcus throat and skin isolates from India and their association with closely related SIC, a streptococcal virulence factor
    Vivek Sagar
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    BMC Microbiol 8:150. 2008
    ..Additionally, the association of these isolates with closely related sic (crs), a multifunctional compliment binding virulence factor, was also explored...
  86. pmc Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes
    Jorge Alegre-Cebollada
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:11235-42. 2010
    ..The pili of the nasty gram-positive human pathogen Streptococcus pyogenes are assembled as single, micrometer long tandem modular proteins of covalently linked repeats of pilin ..
  87. ncbi Mg(2+) signalling defines the group A streptococcal CsrRS (CovRS) regulon
    Ioannis Gryllos
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 65:671-83. 2007
    ..To our knowledge, this study is the first to characterize global gene regulation by a GAS two-component system in response to a specific environmental stimulus...
  88. ncbi Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria
    Rita G Kansal
    Department of Veterans Affairs Medical Center, Research Service, University of Tennessee Health Science Center, Memphis, TN 38104, USA
    J Infect Dis 201:855-65. 2010
    ..Correction of the covS mutation in AP bacteria reverted them back to the WT phenotype. Our data confirm that covS plays a direct role in regulating GAS virulence...
  89. ncbi Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes
    Chuan Chiang-Ni
    Institute of Basic Medical Sciences, Department of Medical Laboratory Science and Biotechnology, Medical College, National Cheng Kung University, Tainan, Taiwan
    J Formos Med Assoc 107:677-85. 2008
    b>Streptococcus pyogenes (group A streptococcus, GAS) is a ubiquitous and important human bacterial pathogen. This organism possesses several virulence factors to establish infection...
  90. ncbi Identification and biochemical characterization of a eukaryotic-type serine/threonine kinase and its cognate phosphatase in Streptococcus pyogenes: their biological functions and substrate identification
    Hong Jin
    Laboratory of Bacterial Pathogenesis, Department of Pathology, Ohio State University College of Medicine and Public Health, 288A, Tzgournis Medical Research Facility, 420 W 12th Avenue, Columbus, OH 43210 1214, USA
    J Mol Biol 357:1351-72. 2006
    ....
  91. pmc Intra- and interspecies signaling between Streptococcus salivarius and Streptococcus pyogenes mediated by SalA and SalA1 lantibiotic peptides
    M Upton
    Department of Oral and Dental Science, University of Bristol Dental School, Bristol, BS1 2LY, United Kingdom
    J Bacteriol 183:3931-8. 2001
    ..salivaricin A (SalA), that inhibits the growth of a range of streptococci, including all strains of Streptococcus pyogenes. Lantibiotic production is associated with the sal genetic locus comprising salA, the lantibiotic ..
  92. pmc An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis
    Nourtan F Abdeltawab
    Mid South Center for Biodefense and Security, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 4:e1000042. 2008
    ..The association of GAS sepsis with multiple pathways underscores the complexity of traits modulating GAS sepsis and provides a powerful approach for analyzing interactive traits affecting outcomes of other infectious diseases...
  93. pmc Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins
    Izabela Sitkiewicz
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    BMC Microbiol 11:65. 2011
    ..Ten RD2-encoded proteins have significant similarity to proteins involved in conjugative transfer of Streptococcus thermophilus integrative chromosomal elements (ICEs)...
  94. ncbi Antibiofilm activity of coral-associated bacteria against different clinical M serotypes of Streptococcus pyogenes
    Ramalingam Thenmozhi
    Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India
    FEMS Immunol Med Microbiol 57:284-94. 2009
    b>Streptococcus pyogenes is the frequent cause of purulent infections in humans. Formation of a biofilm is one of the important aspects of its pathogenicity...
  95. pmc Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptor
    R Lottenberg
    Department of Medicine, University of Florida, Gainesville 32610
    J Bacteriol 174:5204-10. 1992
    ..The deduced amino acid sequence for the plasmin receptor protein revealed significant similarity (39 to 54% identical amino acid residues) to glyceraldehyde 3-phosphate dehydrogenases...
  96. pmc The 4.5S RNA component of the signal recognition particle is required for group A Streptococcus virulence
    Jeanette Treviño
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Microbiology 156:1342-50. 2010
    ..The SRP from the human pathogen group A Streptococcus (GAS, Streptococcus pyogenes) is predicted to be composed of protein Ffh and 4.5S RNA...
  97. ncbi RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon
    Samantha A Roberts
    Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Microbiol 66:1506-22. 2007
    ..two-component system regulates the transcription of many genes that are crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS)...
  98. pmc Immune recognition of Streptococcus pyogenes by dendritic cells
    Torsten G Loof
    Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 76:2785-92. 2008
    b>Streptococcus pyogenes is one of the most frequent human pathogens. Recent studies have identified dendritic cells (DCs) as important contributors to host defense against S. pyogenes...
  99. pmc M-protein and other intrinsic virulence factors of Streptococcus pyogenes are encoded on an ancient pathogenicity island
    Alexandre Panchaud
    Department of Fundamental Microbiology, University of Lausanne, Quartier UNIL Sorge, Bâtiment Biophore, Lausanne, Switzerland
    BMC Genomics 10:198. 2009
    ..The increasing number of completely sequenced bacterial genomes allows comparing their architecture and genetic makeup. Such new information highlights the crucial role of lateral genetic exchanges in bacterial evolution and speciation...
  100. pmc Rise and persistence of global M1T1 clone of Streptococcus pyogenes
    Ramy K Aziz
    Department of Microbiologyand Immunology, Cairo University, Cairo, Egypt
    Emerg Infect Dis 14:1511-7. 2008
    ....
  101. pmc Characterization of biofilm formation by clinically relevant serotypes of group A streptococci
    Cordula Lembke
    Department of Medical Microbiology and Hospital Hygiene, University Hospital Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Appl Environ Microbiol 72:2864-75. 2006
    b>Streptococcus pyogenes (group A streptococcus [GAS]) is a frequent cause of purulent infections in humans...

Research Grants64

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..contaminated wounds of drug- resistant super bugs like Methicillin-Resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes and Pseudomonas aeruginosa. Fibro-optic capable: Minimally invasive laparoscopic &robotic applications. ..
  2. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Group A Streptococcus (Streptococcus pyogenes or GAS) is the leading cause of human bacterial pharyngitis, an infection state commonly referred to as &..
  3. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus pyogenes (Group A strep), vancomycin resistant enterococcus (VRE), Bacillus anthracis, Listeria monocytogenes and ..
  4. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..The best-known toxin in this family is the highly modified peptide, streptolysin S (SLS, produced by Streptococcus pyogenes). SLS production is required for the infective process, but not essential life processes...
  5. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..phosphohydrolase domain and regulates the expression of glycolytic enzymes and virulence factors of Streptococcus pyogenes in response to low nutrient conditions...
  6. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..During the recent flu pandemic, Streptococcus pyogenes caused about 1/3 of the known cases of superinfection...
  7. Bacteriophage Control of DNA Repair in Streptococcus Pyogenes
    WILLIAM MICHAEL MCSHAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The group A streptococcus (GAS;Streptococcus pyogenes) is a major bacterial pathogen of humans, globally causing over 700,000,000 infections and more than 500,000 deaths each year...
  8. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2009
    Project Summary/Abstract. Group A streptococci (GAS;Streptococcus pyogenes) are remarkable for the wide range of diseases they cause in humans, their sole biological host...
  9. Cryopyrin/NLRP3 Signaling in Inflammation and Innate Immunity
    Gabriel Nunez; Fiscal Year: 2013
    ..in response to Toll-like receptor (TLR) ligands as well as infection with Staphylococcus aureus and Streptococcus pyogenes, two significant human pathogens...
  10. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    b>Streptococcus pyogenes is a ubiquitous and versatile human pathogen...
  11. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..These sequence motifs were first found in MSCRAMMs from Staphylococcus aureus, Streptococcus pyogenes and Borrelia burgdorferi...
  12. MtaR-regulated virulence in Streptococcus agalactiae
    Daniel Shelver; Fiscal Year: 2009
    ..While some pathogens such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium perfringens are armed with a wide variety of toxins and other molecules that damage the ..
  13. CYTOLYSIN-MEDIATED TRANSLOCATION IN S. PYOGENES VIRULENC
    Michael G Caparon; Fiscal Year: 2013
    ..SLO is produced by Streptococcus pyogenes, an important cause of pharyngitis and other serious diseases including scarlet fever, rheumatic fever and ..
  14. Anti-MRSA activity of a Bacillus pumilus natural isolate
    Michiko M Nakano; Fiscal Year: 2010
    ..aureus, including HA- and CA-MRSA, as well as Streptococcus pyogenes, a group A Streptococcus. Both S...
  15. Pore Formation by Cholesterol Dependent Cytolysins
    Rodney K Tweten; Fiscal Year: 2013
    ..It was recently shown that the CDC of Streptococcus pyogenes, streptolysin O (SLO), transports a specific protein into eukaryotic cells by a pore-independent mechanism...
  16. Use of antifibronectin agents to target fibrosis in mammary cancer
    BIANCA RAQUEL TOMASINI-JOHANSSON; Fiscal Year: 2013
    ..Two types of inhibitors will be tested. The first type of inhibitor is a peptide derived from Streptococcus pyogenes, termed FUD for Functional Upstream Domain, which we have characterized extensively as a potent and ..
  17. Characterizing Exportal by a Polymyxin B Resistance-Based Mutagenic Approach
    Luis Alberto Vega; Fiscal Year: 2010
    ..In Streptococcus pyogenes secretion of the major virulence factor SpeB occurs via the ExPortal, an anionic membrane microdomain ..
  18. PROTEASE AND ROP GENES IN S. PYOGENES VIRULENCE
    Michael G Caparon; Fiscal Year: 2013
    ..understanding the pathogenesis of any of the myriad serious diseases caused by the Gram- positive pathogen Streptococcus pyogenes (group A streptococcus)...
  19. 2012 International Conference on Gram-positive Pathogens
    Paul D Fey; Fiscal Year: 2012
    ..provided by the applicant): Infections caused by gram-positive pathogens, including Staphylococcus aureus, Streptococcus pyogenes, Clostridium difficile, and Enterococcus faecium, among others, are a burden on our society causing ..
  20. Al-2-Dependent Quorum Sensing in the Gram-Positive Bacterium Streptococcus pyogen
    Michael J Federle; Fiscal Year: 2010
    ..aims to define the role of AI-2 and the AI-2 signal transduction cascade in the Gram-positive pathogen Streptococcus pyogenes. To achieve these goals, I will develop genetic tools and use them to identify and characterize the S...
  21. Evolutionary genomics and population genetics of pathogenic streptococci
    Michael J Stanhope; Fiscal Year: 2012
    ..developed as part of this project, conduct a comprehensive survey of noncoding functional elements in the Streptococcus Pyogenes, Mutans, and Mitis groups. 5...
  22. Antigen Detection Assay for the Diagnosis of Visceral Leismaniasis
    Claudia Abeijon; Fiscal Year: 2010
    ..been successfully used for the diagnosis of different infectious diseases including sore throat caused by Streptococcus pyogenes, hepatitis, pneumonia caused by Streptococcus pneumoniae or Legionella pneumophilla, and amoebiasis...
  23. Sortase-mediated protein engineering for the study of host-pathogen interactions
    Hidde L Ploegh; Fiscal Year: 2013
    ..accomplished not only through site-directed mutagenesis of the Srt A enzymes of Staphylococcus aureus and Streptococcus pyogenes, but also through the use of other classes of sortases (e.g. SrtB from S. aureus or B. anthracis)...
  24. MECHANISMS INVOLVED IN FLAVIN-LINKED OXYGEN METABOLISM
    Al Claiborne; Fiscal Year: 2005
    ..of this group: (1) NADH oxidase (Nox; 2NADH + O2 to 2NAD+ + 2H2O) from the severe human pathogen Streptococcus pyogenes, (2) NADH peroxidase (Npx; NADH + H2O2 - to NAD+ + 2H2O) from Enterococcus faecalis, and (3) alpha-..
  25. Heme Acquisition in Group A Streptococcus
    Benfang Lei; Fiscal Year: 2005
    Hemolytic Streptococcus pyogenes, commonly referred as Group A Streptococcus (GAS), is an important human pathogen causing pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, toxic shock syndrome, acute rheumatic fever, ..
  26. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003
    ..gonorrhoeae Por, similar to Streptococcus pyogenes M protein, which binds both factor H and C4BP...
  27. DNA SEQUENCE OF STAPHYLOCOCCUS AUREUS 8325 GENOME
    JOHN LANDOLO; Fiscal Year: 1999
    ..shortly, including our own genomic sequencing of the important human pathogens Neisseria gonorrhoeae and Streptococcus pyogenes. Collectively, these studies will considerably enhance our understanding of procaryotic molecular ..
  28. STREPTOCOCCAL HYALURONATE CAPSULE
    Ivo van de Rijn; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Abstract): Lancefield group A streptococci (Streptococcus pyogenes) are one of the most prevalent human pathogens (25 million infection/year) capable of causing a variety of severe suppurative ..
  29. The Pseudomonas Aeruginosa Biofilm Dispersion Response
    David Davies; Fiscal Year: 2009
    ..aerugjnosa, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Streptococcus pyogenes, Staphylococcus aureus, and Candida albicans...
  30. STRUCTURAL STUDIES OF SUPERANTIGENS
    Douglas Ohlendorf; Fiscal Year: 1999
    ..The best characterized superantigens are the microbial toxins from Staphylococcus aureus and Streptococcus pyogenes. The S...
  31. Automated Simultaneous Detection of Bioterrorism Agents
    David Ecker; Fiscal Year: 2005
    ..TIGER has also detected and strain-typed other medically important bacteria and viruses including Streptococcus pyogenes and Adenovirus in clinical samples...
  32. MICROBIAL GENOME PROJECT STREPTOCOCCUS MUTANS
    JOSEPH FERRETTI; Fiscal Year: 2000
    ..Roe of the University of Oklahoma, Norman, is completing the sequence of the genome of Streptococcus pyogenes and assisting the laboratory of David W...
  33. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
    ..low G+C Gram-positive genomes including the pathogens Listeria monocytogenes, Staphylococcus aureus, Streptococcus pyogenes, and the nonpathogenic dairy fermentation bacterium Lactococcus lactis...
  34. MOLECULAR ANALYSIS OF STAPHYLOCOCCAL TYPE C ENTEROTOXINS
    Gregory Bohach; Fiscal Year: 1999
    ..SE belong to a family of pyrogenic toxins (PT) produced by Staphylococcus aureus and Streptococcus pyogenes. The PT family, which contains prototypic microbial superantigens, shares a set of immunomodulating ..
  35. Peptide & antibodies as antidotes for superantigens
    Kunwar Shailubhai; Fiscal Year: 2006
    ..superantigens including the two dozens of pyrogenic exotoxins secreted by Staphylococcus aureus (SEB) and Streptococcus pyogenes (SPEA) and toxic shock syndrome toxin-1 (TSST-1) are most potent and could potentially be used for ..
  36. COMPARATIVE ANALYSIS OF GROUP A AND B STREPTOCCAL GENOME
    JOSEPH FERRETTI; Fiscal Year: 2000
    ..At the present time, the complete sequence of group A streptococcus (GAS, Streptococcus pyogenes) genome is being determined at the University of Oklahoma...
  37. MOLECULAR INTERACTIONS BETWEEN SPEA AND THE TCR
    CARLEEN COLLINS; Fiscal Year: 2002
    ..this country and abroad, there has been a resurgence of acute, often life threatening infections due to Streptococcus pyogenes (group A streptococcus)...
  38. HOST CELL RESPONSE TO STREPTOCOCCUS PYOGENES
    Michael Caparon; Fiscal Year: 1999
    ..incidence of rheumatic fever and other severe and invasive diseases caused by the gram positive bacterium Streptococcus pyogenes. Reports in the popular media referring to S...
  39. MOLECULAR ANALYSIS OF STAPHYLOCOCCAL TYPE C ENTEROTOXINS
    Gregory Bohach; Fiscal Year: 1993
    ..Ents) are part of a larger family of pyrogenic toxins (PTs) produced by Staphylococcus aureus and Streptococcus pyogenes. Although they are known mainly for their ability to cause food poisoning, Ents, like other PTs, can cause ..
  40. SUPERANTIGENS AND THE MHC--STRUCTURE AND FUNCTION
    Richard Cook; Fiscal Year: 2000
    ..studies of the superantigen (Sag) exotoxins produced by pathogenetic strains of Staphylococcus aureus and Streptococcus pyogenes. We will focus primarily on four members of this family, the staphylococcal enterotoxins SEA, SEB and SEE ..
  41. INTERACTION OF ORAL STREPTOCOCCI WITH ANIMAL TISSUES
    MURRAY STINSON; Fiscal Year: 2001
    ..Pathogenesis involves immune complexes in the kidneys but the mechanism remains poorly defined. Streptococcus pyogenes and several species of oral streptococci produce a cationic histone-like protein (HlpA) and lipoteichoic ..
  42. DETERMINANTS OF VIRULENCE IN GROUP A STREPTOCOCCI
    JOSEPH FERRETTI; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): Streptococcus pyogenes (group A streptococcus) is one of the most common pathogens infecting man, causing a wide range of infections from asymptomatic carriage to explosive, life-..
  43. Response of Streptococcus pyogenes to Nutritional Stress
    JOSEPH FERRETTI; Fiscal Year: 2005
    b>Streptococcus pyogenes (group A streptococcus, GAS) causes various infections of humans including the skin, throat, deep tissue, and even the bloodstream...
  44. Receptor-Based Therapeutics for Enterotoxins
    DAVID KRANZ; Fiscal Year: 2009
    ..Most of the known bacterial SAgs are expressed by Staphylococcus aureus and Streptococcus pyogenes. These include select agents of bioterrorism such as staphylococcal enterotoxin B (SEB) that has been ..
  45. HUMAN GR A CHO ANTIBODIES & THEIR PHAGOCYTIC PROPERTIES
    JOHN ZABRISKIE; Fiscal Year: 1999
    ..In this proposal the investigator plans to study the immunogenicity of the Group A carbohydrate of Streptococcus pyogenes ...
  46. SEQUENCING MOUSE GENOMIC CLONES
    Bruce Roe; Fiscal Year: 1999
    ..completing approximately 2 million bases of human DNA sequence and approximately one-fold coverage of the Streptococcus pyogenes and Neisseria gonorrhoeae genomes within the last year...
  47. Real-Time Monitoring Technology for Airborne Pathogens
    GEORGE BAJSZAR; Fiscal Year: 2004
    ..biocapture/biodetection technology will be equally applicable for monitoring of other airborne bacteria (Streptococcus pyogenes), fungi (Aspergillus fumigatus), and airborne viruses...
  48. POLYPHENOL OXIDASES AS ANTIADHESINS
    RONALD DOYLE; Fiscal Year: 1999
    ..6. Study how PPO abolishes the ability of Streptococcus pyogenes to bind a human laryngeal cell line and to bind to soluble fibronectin...
  49. RNA Polymerase Sigma Factors in Streptococcus pyogenes
    CHARLES MORAN; Fiscal Year: 2005
    b>Streptococcus pyogenes (the group A streptococcus or GAS) is an important and common human pathogen...
  50. PHOTOTHERAPY OF ANTIBIOTIC RESISTANT WOUND INFECTIONS
    Merrill Biel; Fiscal Year: 2000
    ..PDT destruction of antibiotic resistant Staphylococcus aureus in vivo and antibiotic resistant Streptococcus pyogenes and Pseudomonas aeruginosa in vitro has been demonstrated using methylene blue...
  51. FILAMENTOUS INFLUENZA VIRUS AND MICROBIAL COLONIZATION
    Paul Roberts; Fiscal Year: 2004
    ..an increased susceptibility to secondary bacterial pulmonary infections, particularly with the pathogens Streptococcus pyogenes and Streptococcus pneumoniae...
  52. Real-Time Detection of Airborne Mycobacteria
    IHAB ABDEL HAMID; Fiscal Year: 2001
    ..real-time detection of Mycobacterium tuberculosis and other airborne pathogens: Legionella pneumophila, Streptococcus pyogenes and Aspergillus fumigatus. 2...
  53. ENGINEERED BIOSYNTHESIS OF NOVEL KETOLIDE ANTIBIOTICS
    Kevin Reynolds; Fiscal Year: 2000
    ..hold promise as a solution to the increase in erythromycin- resistant bacterial pathogens, including Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and some enterococci...
  54. Antigen Detection Assay for Tuberculosis
    Antonio Campos Neto; Fiscal Year: 2006
    ..hepatitis, pneumonia caused by Streptococcus pneumoniae or Legionella pneumophilla, sore throat cause by Streptococcus pyogenes, and amoebiasis...
  55. PRODUCTION OF NATURAL KILLER CELLS
    SYLVIA POLLACK; Fiscal Year: 1992
    ..modifiers AIPP (2-amino-5-iodo-6-phenyl-4-pyrimidinone) and OK-432 (a pharmaceutical preparation of Streptococcus pyogenes)...
  56. STREPTOCOCCUS PYOGENES--CLONAL ANALYSIS OF VIRULENCE
    Edward Graviss; Fiscal Year: 2000
    ..e., Streptococcus pyogenes), it has been shown that SpeB is cysteine protease and that it is important virulence factor in ..
  57. Iron acquisition in Streptococcus pyogenes
    GRISELLE MONTANEZ; Fiscal Year: 2004
    b>Streptococcus pyogenes is an important human pathogen that causes mild to aggressive life threatening infections. An unexplained increase in the frequency and severity of streptococcal infections has been observed since the 1980s...
  58. Streptococcal-Zebrafish Model of Bacterial Pathogenesis
    MELODY NEELY; Fiscal Year: 2002
    ..disease: a natural pathogen of both fish and humans, Streptococcus iniae and a human-specific pathogen, Streptococcus pyogenes. While S. iniae primarily causes systemic disease in the zebrafish following intra-muscular injection, S...
  59. Macrolide Discovery through Glycosylation
    Alex Romero; Fiscal Year: 2004
    ..having improved MICs0 and MIC90 activity against clinically relevant resistant pathogens, specifically, Streptococcus pyogenes and Streptococcus pneumoniae, and as well as improved activity against Haemophilus influenzae...
  60. STREPTOCOCCAL MULTIENZYME DNA REPLICATION SYSTEM
    James Bullard; Fiscal Year: 2002
    ..phase I study to establish a complete DNA replication system for a prototypical gram-positive pathogen, Streptococcus pyogenes. As in our phase I studies, we plan to continue to exploit available genomic information to permit ..
  61. VIRULENCE, OXYGEN AND PROTEIN F IN STEPTOCOCCUS PYOGENES
    Michael Caparon; Fiscal Year: 2004
    We currently have a very poor understanding of why some infections by the Gram positive pathogen Streptococcus pyogenes result in mild self-limiting disease, while others progress to life-threatening tissue destructive diseases...
  62. GENETIC ANALYSIS OF S PYOGENES VIRULENCE FACTORS
    JUNE SCOTT; Fiscal Year: 2002
    b>Streptococcus pyogenes, the group A streptococcus (GAS) is an important human pathogen causing frequent self-limiting diseases which may lead to serious sequelae...
  63. The characterization of GAS hyaluronidase
    CLARISE STARR; Fiscal Year: 2004
    ..The specific aims are 1) to determine if Streptococcus pyogenes hyaluronidase is a spreading factor in a murine model of skin and soft tissue infection...
  64. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..