streptococcus pneumoniae

Summary

Summary: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.

Top Publications

  1. ncbi Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
    Katherine L O'Brien
    GAVI s PneumoADIP, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 374:893-902. 2009
  2. pmc Rapid pneumococcal evolution in response to clinical interventions
    Nicholas J Croucher
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 331:430-4. 2011
  3. ncbi Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    Lionel A Mandell
    McMaster University Medical School, Hamilton, Ontario, Canada
    Clin Infect Dis 44:S27-72. 2007
  4. ncbi Streptococcus pneumoniae colonisation: the key to pneumococcal disease
    D Bogaert
    Laboratory of Paediatrics, Erasmus MC Sophia, Rotterdam, Netherlands
    Lancet Infect Dis 4:144-54. 2004
  5. pmc Serotype replacement in disease after pneumococcal vaccination
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:1962-73. 2011
  6. ncbi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
  7. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
  8. ncbi The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Nat Rev Microbiol 6:288-301. 2008
  9. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
  10. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010

Detail Information

Publications341 found, 100 shown here

  1. ncbi Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
    Katherine L O'Brien
    GAVI s PneumoADIP, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 374:893-902. 2009
    b>Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children worldwide. However, many countries lack national estimates of disease burden...
  2. pmc Rapid pneumococcal evolution in response to clinical interventions
    Nicholas J Croucher
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 331:430-4. 2011
    Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination...
  3. ncbi Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    Lionel A Mandell
    McMaster University Medical School, Hamilton, Ontario, Canada
    Clin Infect Dis 44:S27-72. 2007
  4. ncbi Streptococcus pneumoniae colonisation: the key to pneumococcal disease
    D Bogaert
    Laboratory of Paediatrics, Erasmus MC Sophia, Rotterdam, Netherlands
    Lancet Infect Dis 4:144-54. 2004
    b>Streptococcus pneumoniae is an important pathogen causing invasive diseases such as sepsis, meningitis, and pneumonia...
  5. pmc Serotype replacement in disease after pneumococcal vaccination
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:1962-73. 2011
    ..We conclude by discussing the future potential for serotype replacement in disease and the need for continuing surveillance...
  6. ncbi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
    ..Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children...
  7. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
    ..descent are demonstrated with a number of examples, including the simple Spain(23F)-1 clonal complex of Streptococcus pneumoniae, "population snapshots" of the entire S...
  8. ncbi The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Nat Rev Microbiol 6:288-301. 2008
    b>Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway...
  9. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
    b>Streptococcus pneumoniae (pneumococcus) is the most common cause of community-acquired pneumonia, with high morbidity and mortality worldwide. A major feature of pneumococcal pneumonia is an abundant neutrophil infiltration ...
  10. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
    b>Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.
  11. pmc Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes
    Stephen D Bentley
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e31. 2006
    ..We provide the sequences of the capsular biosynthetic genes of all 90 serotypes of Streptococcus pneumoniae and relate these to the known polysaccharide structures and patterns of immunological reactivity of ..
  12. pmc Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome
    N Luisa Hiller
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, PA 15212, USA
    J Bacteriol 189:8186-95. 2007
    ..We sequenced the genomes of eight nasopharyngeal strains of Streptococcus pneumoniae isolated from pediatric patients with upper respiratory symptoms and performed quantitative genomic ..
  13. pmc Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    J Clin Microbiol 49:1784-9. 2011
    Identification of Streptococcus pneumoniae in the nasopharynx is critical for an understanding of transmission, estimates of vaccine efficacy, and possible replacement disease...
  14. pmc Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates
    Rekha Pai
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:124-31. 2006
    Accurate serotyping is essential to monitor the changes in the seroepidemiology of Streptococcus pneumoniae. We devised a simple and schematic sequence-based system of seven multiplex PCRs, in a sequence order based upon Active Bacterial ..
  15. ncbi Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    S Black
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 19:187-95. 2000
    ....
  16. pmc Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
    Tim van Opijnen
    Howard Hughes Medical Institute, and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nat Methods 6:767-72. 2009
    ..Using this approach, we determined fitness for each gene of Streptococcus pneumoniae, a causative agent of pneumonia and meningitis...
  17. ncbi Hyper-recombination, diversity, and antibiotic resistance in pneumococcus
    William Paul Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Science 324:1454-7. 2009
    b>Streptococcus pneumoniae is a pathogen of global importance that frequently transfers genetic material between strains and on occasion across species boundaries...
  18. pmc Pathogenesis and pathophysiology of pneumococcal meningitis
    Barry B Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Microbiol Rev 24:557-91. 2011
    ..The most common route of infection starts by nasopharyngeal colonization by Streptococcus pneumoniae, which must avoid mucosal entrapment and evade the host immune system after local activation...
  19. pmc Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands
    Judith Spijkerman
    University Medical Center, Utrecht, The Netherlands
    Emerg Infect Dis 17:584-91. 2011
    ..vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands...
  20. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
    ..conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae. METHODS: We enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent ..
  21. ncbi Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London, UK
    Lancet Infect Dis 11:760-8. 2011
    ..We assess the effect of the PCV7 vaccination on VT and NVT disease in England and Wales...
  22. pmc Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study
    Stefan Flasche
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS Med 8:e1001017. 2011
    ....
  23. ncbi The genetic transformation machinery: composition, localization, and mechanism
    Jean Pierre Claverys
    Centre National de la Recherche Scientifique, LMGM UMR, Toulouse, France
    FEMS Microbiol Rev 33:643-56. 2009
    ..A series of observations made in Bacillus subtilis and Streptococcus pneumoniae led to the recent emergence of a picture of a unique, highly integrated machine localized at the cell ..
  24. ncbi Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    Christoph J Binder
    Divisions of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0682 USA
    Nat Med 9:736-43. 2003
    ..whether in vivo exposure to pneumococci can affect atherogenesis, we immunized Ldlr(-/-) mice with Streptococcus pneumoniae. This induced high circulating levels of oxLDL-specific IgM and a persistent expansion of oxLDL-specific ..
  25. ncbi Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae
    Marc Prudhomme
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Science 313:89-92. 2006
    ..and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade...
  26. ncbi Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential
    Angela B Brueggemann
    Academic Department of Microbiology and Infectious Disease, John Radcliffe Hospital and Department of Public Health and Primary Care, University of Oxford, Oxford, United Kingdom
    J Infect Dis 187:1424-32. 2003
    By use of multilocus sequence typing, Streptococcus pneumoniae isolates causing invasive disease (n=150) were compared with those from nasopharyngeal carriage (n=351) among children in Oxford...
  27. ncbi Epidemiological differences among pneumococcal serotypes
    William P Hausdorff
    GlaxoSmithKline Biologicals, King of Prussia, PA 19406 2772, USA
    Lancet Infect Dis 5:83-93. 2005
    The bacterial species Streptococcus pneumoniae consists of 90 immunologically distinct serotypes, of which some possess distinct epidemiological properties...
  28. ncbi Pathogenesis, treatment, and prevention of pneumococcal pneumonia
    Tom van der Poll
    Centre for Infection and Immunity Amsterdam, Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Lancet 374:1543-56. 2009
    Pneumococcus remains the most common cause of community-acquired pneumonia worldwide. Streptococcus pneumoniae is well adapted to people, and is a frequent inhabitant of the upper airways in healthy hosts...
  29. ncbi Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
    Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S...
  30. pmc A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae
    Alessandro Bidossi
    Lab Microbiologia Molecolare e Biotecnologia, Dip Biologia Molecolare, Universita di Siena, Siena, Italy
    PLoS ONE 7:e33320. 2012
    The aerotolerant anaerobe Streptococcus pneumoniae is part of the normal nasopharyngeal microbiota of humans and one of the most important invasive pathogens...
  31. pmc Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA
    PLoS ONE 4:e8540. 2009
    ..Furthermore, no evidence was found for increased frequency of risk factors for H1N1pdm disease...
  32. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    ..This study assessed the efficacy of a novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein D in prevention of acute otitis media.
  33. pmc The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms
    Catherine Hyams
    Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
    Infect Immun 78:704-15. 2010
    The Streptococcus pneumoniae capsule is vital for virulence and may inhibit complement activity and phagocytosis. However, there are only limited data on the mechanisms by which the capsule affects complement and the consequences for S...
  34. pmc A new pneumococcal serotype, 11E, has a variably inactivated wcjE gene
    Juan J Calix
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Infect Dis 202:29-38. 2010
    ..and biochemically distinct subtypes-11Aalpha and 11Abeta-were discovered among serotype 11A isolates of Streptococcus pneumoniae. Sequence comparison of the capsular polysaccharide synthesis (cps) loci of the 2 subtypes identified ..
  35. pmc Mugsy: fast multiple alignment of closely related whole genomes
    Samuel V Angiuoli
    Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA
    Bioinformatics 27:334-42. 2011
    ..This increasing volume of data requires tools that can quickly compare multiple whole-genome sequences, millions of base pairs in length, to aid in the study of populations, pan-genomes, and genome evolution...
  36. ncbi Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003
    Richard A Adegbola
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Trop Med Int Health 11:1128-35. 2006
    ..To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia...
  37. ncbi Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  38. ncbi Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    Clin Infect Dis 50:1468-76. 2010
    ..of a pneumococcal vaccine of restricted valency, we studied the pattern of nasopharyngeal carriage of Streptococcus pneumoniae and its transmission in Gambian villages over time. METHODS...
  39. ncbi Construction of new unencapsulated (rough) strains of Streptococcus pneumoniae
    Barbara J Pearce
    Dipartimento di Biologia di Molecolare, Universita di Siena, Italy
    Res Microbiol 153:243-7. 2002
    To construct rough strains of Streptococcus pneumoniae in which the capsule locus was completely deleted, a genetic cassette to be used as a donor DNA in transformation was developed...
  40. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 43:673-9. 2006
    To prepare for the introduction of a pneumococcal conjugate vaccine of restricted valency, we studied the nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers.
  41. ncbi Resistance among Streptococcus pneumoniae: Implications for drug selection
    Peter C Appelbaum
    Departments of Pathology and Clinical Microbiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
    Clin Infect Dis 34:1613-20. 2002
    b>Streptococcus pneumoniae is an important pathogen in many community-acquired respiratory infections in the United States and a leading cause of morbidity and mortality worldwide. Unfortunately, S...
  42. ncbi CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection
    David Bikard
    Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA
    Cell Host Microbe 12:177-86. 2012
    ..We programmed the human pathogen Streptococcus pneumoniae with CRISPR sequences that target capsule genes, an essential pneumococcal virulence factor, and show ..
  43. pmc Simple, rapid latex agglutination test for serotyping of pneumococci (Pneumotest-Latex)
    H C Slotved
    Serum Production Unit, Department of Bacteriology, Mycology and Parasitology, Division of Microbiology and Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Clin Microbiol 42:2518-22. 2004
    The "gold standard" for epidemiological typing of Streptococcus pneumoniae (pneumococcus) is the capsular reaction test (Neufeld test) with antisera against the 90 pneumococcal polysaccharide capsules, i.e., serotyping...
  44. pmc Plasminogen- and fibronectin-binding protein B is involved in the adherence of Streptococcus pneumoniae to human epithelial cells
    Salvatore Papasergi
    Elie Metchnikoff Department, Universita di Messina, Messina I 98125, Italy
    J Biol Chem 285:7517-24. 2010
    b>Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The ability of this bacterium to adhere to epithelial cells is considered as an essential early step in colonization and infection...
  45. pmc Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia
    Sandra Ribes
    Department of Geriatrics, Evang Krankenhaus Göttingen Weende, An der Lutter 24, D 37075 Gottingen, Germany
    Infect Immun 78:865-71. 2010
    ..TLR2, -4, and -9 are important in the responses against Streptococcus pneumoniae, the most common agent causing bacterial meningitis beyond the neonatal period...
  46. pmc Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants
    Brenda A Kwambana
    Bacterial Diseases Programme, Medical Research Council Laboratories UK, Atlantic Boulevard, Banjul, PO Box 273, The Gambia
    BMC Infect Dis 11:175. 2011
    ..type b (Hib), Staphylococcus aureus and Moraxella catarrhalis are important causes of invasive and mucosal bacterial disease among children, co-carriage with Streptococcus pneumoniae during infancy has not been determined in West Africa.
  47. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
    The role of respiratory viruses in the transmission of Streptococcus pneumoniae is poorly understood...
  48. ncbi Global status of Haemophilus influenzae type b and pneumococcal conjugate vaccines: evidence, policies, and introductions
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, International Vaccine Access Center, Baltimore, Maryland, USA
    Curr Opin Infect Dis 23:236-41. 2010
    ..leading causes of bacterial meningitis and pneumonia in children, Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae, are vaccine preventable...
  49. ncbi Streptococcus pneumoniae: does antimicrobial resistance matter?
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:210-38. 2009
    Over the past 3 decades, antimicrobial resistance among Streptococcus pneumoniae, the most common cause of community-acquired pneumonia (CAP), has escalated dramatically worldwide...
  50. pmc Interleukin-17A mediates acquired immunity to pneumococcal colonization
    Ying Jie Lu
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e1000159. 2008
    ..We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines...
  51. pmc Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR
    C E Corless
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, United Kingdom
    J Clin Microbiol 39:1553-8. 2001
    ..Detection System (TaqMan) for the detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae from clinical samples of cerebrospinal fluid (CSF), plasma, serum, and whole blood...
  52. pmc Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
    Edel A McNeela
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 6:e1001191. 2010
    Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines...
  53. pmc Revisiting pneumococcal carriage by use of broth enrichment and PCR techniques for enhanced detection of carriage and serotypes
    Maria da Gloria Carvalho
    Streptococcus Laboratory, Respiratory Disease Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, GA 30329, USA
    J Clin Microbiol 48:1611-8. 2010
    ..A PCR-based approach that employed a broth enrichment step appeared to best enhance the detection of mixed serotypes and low-density pneumococcal carriage...
  54. pmc Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 614, Birmingham, AL 35294, USA
    J Clin Microbiol 45:1225-33. 2007
    ..This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype...
  55. pmc Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data
    E J Feil
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, United Kingdom
    Genetics 154:1439-50. 2000
    ..This technique has been applied to 575 isolates of Streptococcus pneumoniae and identifies a number of discrete clonal complexes...
  56. ncbi Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae
    Katherine L O'Brien
    Pediatr Infect Dis J 22:e1-11. 2003
    ..Numerous studies evaluating the efficacy of conjugate pneumococcal vaccines are being conducted or planned throughout the world. Some of these studies are evaluating the effect of vaccine on nasopharyngeal (NP) carriage...
  57. ncbi Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells
    Satoshi Ishizuka
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Infect Dis 188:1928-39. 2003
    To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S...
  58. pmc Continued impact of pneumococcal conjugate vaccine on carriage in young children
    Susan S Huang
    Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Pediatrics 124:e1-11. 2009
    The goals were to assess serial changes in Streptococcus pneumoniae serotypes and antibiotic resistance in young children and to evaluate whether risk factors for carriage have been altered by heptavalent pneumococcal conjugate vaccine (..
  59. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
    Clin Infect Dis 46:807-14. 2008
    To prepare for national introduction of a pneumococcal conjugate vaccine of restricted valency, we studied nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants.
  60. pmc A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting
    M Hussain
    Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency Centre for Infections, London, UK
    Epidemiol Infect 133:891-8. 2005
    ..pneumoniae is common in a UK setting in the pre-conjugate vaccine era. PCV would protect against a large proportion of carriage isolates. However, the impact of vaccination on non-vaccine serotypes will need to be monitored...
  61. pmc A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults
    Neil French
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    N Engl J Med 362:812-22. 2010
    b>Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa...
  62. ncbi An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics
    Julia Leimkugel
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 192:192-9. 2005
    ..These epidemics are generally caused by Neisseria meningitidis, an organism that is considered to be uniquely capable of causing meningitis epidemics...
  63. ncbi Induction of competence regulons as a general response to stress in gram-positive bacteria
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 31062 Toulouse Cedex 9, France
    Annu Rev Microbiol 60:451-75. 2006
    Bacterial transformation, a programmed mechanism for genetic exchange originally discovered in Streptococcus pneumoniae, is widespread in bacteria. It is based on the uptake and integration of exogenous DNA into the recipient genome...
  64. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
    The 92 capsular serotypes of Streptococcus pneumoniae differ greatly in nasopharyngeal carriage prevalence, invasiveness, and disease incidence...
  65. ncbi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  66. pmc Genetic basis for the new pneumococcal serotype, 6C
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, BBRB 614, Birmingham, AL 35294, USA
    Infect Immun 75:4482-9. 2007
    ..These findings indicate that the 6C capsule type originated more than 27 years ago by a single recombination event in a 6A locus in which 6A wciN was replaced by a gene of unknown origin...
  67. ncbi First report of putative Streptococcus pneumoniae serotype 6D among nasopharyngeal isolates from Fijian children
    Ping Jin
    Bao an Maternity and Child Health Hospital, Shenzhen, People s Republic of China
    J Infect Dis 200:1375-80. 2009
    A putative Streptococcus pneumoniae serotype, 6D, resulting from the introduction of wciN(beta) into serotype 6B has been proposed.
  68. pmc Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
    There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these patterns are poorly ..
  69. pmc Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation
    M S Lee
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Bacteriol 181:5004-16. 1999
    Competence for genetic transformation in Streptococcus pneumoniae is regulated by a quorum-sensing system encoded by two genetic loci, comCDE and comAB...
  70. pmc FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis
    Menna R Clatworthy
    The Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, CB2 2XY, UK
    J Exp Med 199:717-23. 2004
    ..Therefore, we examined whether FcgammaRIIb controls the response to Streptococcus pneumoniae. Macrophages from FcgammaRIIb-deficient mice showed increased antibody-dependent phagocytosis of ..
  71. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..virus 3 (HPIV-3), and influenza virus on the abilities of nontypeable Haemophilus influenzae and Streptococcus pneumoniae to adhere to respiratory epithelial cells and how these viruses alter the expression of known receptors ..
  72. pmc 7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement?
    Yoon Hong Choi
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London, United Kingdom
    PLoS ONE 6:e26190. 2011
    ..However, recent surveillance data show a more rapid replacement of PCV7 IPD cases by non-PCV7 IPD cases than was seen in the US...
  73. pmc Sialic acid transport contributes to pneumococcal colonization
    Carolyn Marion
    Center for Microbial Pathogenesis, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205 2696, USA
    Infect Immun 79:1262-9. 2011
    b>Streptococcus pneumoniae is a major cause of pneumonia and meningitis. Airway colonization is a necessary precursor to disease, but little is known about how the bacteria establish and maintain colonization...
  74. pmc T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization
    Kristin L Moffitt
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Cell Host Microbe 9:158-65. 2011
    b>Streptococcus pneumoniae is a leading cause of mortality in young children...
  75. ncbi Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 368:1495-502. 2006
    ..Our aim was to assess the effectiveness of the vaccine against various pneumococcal serotypes, and to measure the effectiveness of the recommended dose schedule and of catch-up and incomplete schedules...
  76. pmc Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
    ....
  77. pmc CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae
    Sandra M Carvalho
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    PLoS ONE 6:e26707. 2011
    ..In the human pathogen Streptococcus pneumoniae, links between CcpA and virulence have been established, but its role as a master regulator in different ..
  78. pmc Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching
    William P Hanage
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Pediatr Infect Dis J 30:302-8. 2011
    Vaccination against 7 serotypes of Streptococcus pneumoniae has led to the near extinction of vaccine serotypes in both disease and asymptomatic carriage. In carriage, vaccine serotypes have been replaced by nonvaccine serotypes.
  79. pmc Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study
    So Hyun Kim
    Asia Pacific Foundation for Infectious Diseases, Seoul, South Korea
    Antimicrob Agents Chemother 56:1418-26. 2012
    Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7)...
  80. ncbi Effectiveness of the new serotypes in the 13-valent pneumococcal conjugate vaccine
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Services, Colindale, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Vaccine 29:9127-31. 2011
    ..VE for serotypes 1 and 3 was 62% and 66% respectively although confidence intervals spanned zero. IPD due to PCV13-only serotypes halved in children under 2 years in the study period...
  81. ncbi Structural basis of pore formation by the bacterial toxin pneumolysin
    Sarah J Tilley
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, United Kingdom
    Cell 121:247-56. 2005
    ..With an oligomer size of up to 44 subunits in the pore, this assembly creates a transmembrane channel 260 A in diameter lined by 176 beta strands...
  82. ncbi Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae
    C Blomberg
    Swedish Institute for Infectious Disease Control, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden
    J Infect Dis 199:1032-42. 2009
    The invasive disease potential (IDP) of Streptococcus pneumoniae differs between serotypes, but the reason for this is unknown.
  83. ncbi Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells
    Simone Bergmann
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    J Cell Sci 122:256-67. 2009
    By interacting with components of the human host, including extracellular matrix (ECM) proteins, Streptococcus pneumoniae has evolved various strategies for colonization...
  84. pmc The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates
    Concha Nieto
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 5:e11289. 2010
    ..the relBE family is one of the most abundant, being present in the three first sequenced strains of Streptococcus pneumoniae (D39, TIGR4 and R6)...
  85. pmc Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine
    Silvio D Brugger
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    PLoS ONE 5:e11638. 2010
    Simultaneous carriage of more than one strain of Streptococcus pneumoniae promotes horizontal gene transfer events and may lead to capsule switch and acquisition of antibiotic resistance...
  86. ncbi Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines
    Gail L Rodgers
    Scientific Affairs and Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA 19426, USA
    Vaccine 27:3802-10. 2009
    ..b>Streptococcus pneumoniae causes 30-60% of AOM cases worldwide...
  87. ncbi Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:189-209. 2009
    b>Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, meningitis, and bacteremia in children and adults...
  88. ncbi Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains
    Elske J M van Gils
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Infectious Diseases, 3508 AB Utrecht, The Netherlands
    JAMA 304:1099-106. 2010
    ..Because spontaneous fluctuations in time and antibiotic selective pressure may have induced this serotype 19A increase, controlled studies are needed to assess the role of PCV-7...
  89. pmc Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81
    Nicholas J Croucher
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, United Kingdom
    J Bacteriol 191:1480-9. 2009
    b>Streptococcus pneumoniae is a human commensal and pathogen able to cause a variety of diseases that annually result in over a million deaths worldwide. The S...
  90. pmc Antimicrobial drug use and resistance in Europe
    Nienke van de Sande-Bruinsma
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 14:1722-30. 2008
    ..the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that ..
  91. ncbi Acute otitis media caused by Moraxella catarrhalis: epidemiologic and clinical characteristics
    Arnon Broides
    Pediatric Immunology Clinic, Pediatric Emergency Department, Soroka University Medical Center, Beer Sheva, Israel
    Clin Infect Dis 49:1641-7. 2009
    ..This study describes the epidemiologic, microbiologic, and otologic features and selected signs and symptoms of acute otitis media (AOM) caused by Moraxella catarrhalis and compares them with AOM caused by other bacterial pathogens...
  92. ncbi Temporal trends in invasive pneumococcal disease and pneumococcal serotypes over 7 decades
    Zitta B Harboe
    National Neisseria and Streptococcus Reference Center, Department of Bacteriology, Mycology, and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Clin Infect Dis 50:329-37. 2010
    ..We explored historical trends of invasive pneumococcal disease (IPD) and pneumococcal serotypes in a population exposed to limited antibiotic selective pressure and conjugate pneumococcal vaccination (PCV)...
  93. ncbi Invasive disease and paediatric carriage of Streptococcus pneumoniae in Ghana
    Eric S Donkor
    Department of Microbiology, University of Ghana Medical School, Accra, Ghana
    Scand J Infect Dis 42:254-9. 2010
    This study was carried out primarily to evaluate the public health burden related to Streptococcus pneumoniae in Ghana and to provide related preliminary molecular epidemiological data on the organism...
  94. pmc Insights into the interaction between influenza virus and pneumococcus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Clin Microbiol Rev 19:571-82. 2006
    ..multiple mechanisms underlying the interaction between influenza virus and bacterial pathogens such as Streptococcus pneumoniae. There is ample evidence to support the historical view that influenza virus alters the lungs in a way ..
  95. ncbi Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
    The 2,160,837-base pair genome sequence of an isolate of Streptococcus pneumoniae, a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted coding regions; of these, 1440 (64%) were ..
  96. pmc Nasopharyngeal versus oropharyngeal sampling for detection of pneumococcal carriage in adults
    James P Watt
    Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, 621 N Washington St, Baltimore, MD 21205, USA
    J Clin Microbiol 42:4974-6. 2004
    ..Sampling both sites may give more accurate results than sampling either site alone in studies of pneumococcal carriage in adults...
  97. ncbi Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA
    D E Briles
    Departments of Microbiology and Pediatrics, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 182:1694-701. 2000
    ..is known to elicit an antibody in animals that can passively protect mice from infection with Streptococcus pneumoniae. A phase I trial with recombinant PspA showed the protein to be immunogenic in humans...
  98. pmc Characterization of the galU gene of Streptococcus pneumoniae encoding a uridine diphosphoglucose pyrophosphorylase: a gene essential for capsular polysaccharide biosynthesis
    M Mollerach
    Departamento de Microbiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
    J Exp Med 188:2047-56. 1998
    The galU gene of Streptococcus pneumoniae has been cloned and sequenced...
  99. pmc Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical and serological characterization
    Preston E Bratcher
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Microbiology 156:555-60. 2010
    ..However, we now report the discovery of two naturally occurring pneumococcal isolates from Korea that have the serological, genetic and biochemical features predicted for serotype 6D...
  100. ncbi Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: England and Wales, 1996-2006
    Caroline L Trotter
    Department of Social Medicine, University of Bristol, Canynge Hall, UK
    J Infect 60:200-8. 2010
    ..To describe the epidemiology of invasive pneumococcal disease (IPD) in England & Wales in the pre-conjugate vaccine era...
  101. ncbi Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae
    Thierry Izoré
    Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075 CEA, CNRS, UJF, Grenoble, France
    Structure 18:106-15. 2010
    ..The human pathogen Streptococcus pneumoniae carries a single pilus-related adhesin (RrgA) that is key for infection establishment and provides ..

Research Grants78

  1. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for about 40 percent of the total deaths ..
  2. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..3, we will establish in vitro bacterial biofilms with nontypeable Haemophilus influenzae (NTHi) or with Streptococcus pneumoniae (pneumococcus) and determine the viral replication potential in immune and epithelial cells exposed to ..
  3. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..Myx exhibits potent antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and Clostridium difficile in culture...
  4. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..The focus of this proposal is on a clinically important subset of Streptococcus pneumoniae strains (the SP-1) that are pandemic and drug resistant. The aims are to: 1) develop an S...
  5. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..The focus of this proposal is on a clinically important subset of Streptococcus pneumoniae strains (the SP-1) that are pandemic and drug resistant. The aims are to: 1) develop an S...
  6. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus pyogenes (Group A strep), vancomycin resistant enterococcus (VRE), Bacillus ..
  7. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..discovered in the spore-forming bacterium, Bacillus subtilis, but is also found in Staphylococcus aureus, Streptococcus pneumoniae, Listeria monocytogenes, and Bacillus anthracis...
  8. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is normally found as an inhabitant of the human nasopharynx that becomes pathogenic in response to environmental changes...
  9. GENETICS AND VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    JANET L YOTHER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, resulting in 1 to 2 million deaths annually. Serious infection and death result primarily from the ability of S...
  10. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..b>Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood OM...
  11. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..coli, Vibrio) as well as the active bacterial core surveillance project (Streptococcus pneumoniae, N. meningitidis, Listeria monocytogenes, Haemophilus influenzae). We are requesting funding for a ...
  12. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..materials and to injection mold TTs, 2) to confirm our in vitro studies with Haemophilus influenzae and Streptococcus pneumoniae, and quantify synergy and monitor for the development of resistant strains, 3) to assess ototoxicity, ..
  13. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..rhinovirus A/B/C, human bocavirus 1/2/3/4, human parainfluenza virus 1/2/3/4, Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis...
  14. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..is a 37-kb pathogenicity island whose presence has been positively correlated with the ability of Streptococcus pneumoniae to cause human disease...
  15. Dissecting the Function and Regulation of Stress-Induced SUMOylation
    ROBERT CHARLES AUGUSTINE; Fiscal Year: 2013
    ..In addition, several pathogenic bacteria (Listeria monocytogenes, Streptococcus pneumoniae) and viruses (human adenovirus, influenza virus) alter SIS, and this is important for bypassing defenses ..
  16. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    ..Since the recent licensure of a 7-valent vaccine directed against Streptococcus pneumoniae, the relative proportion of cases of OM due to our studied microorganism (nontypeable Haemophilus ..
  17. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..unanticipated genome rearrangements will be used in studies of the infectious agents Vibrio cholera, Streptococcus pneumoniae and Legionella pneumophila...
  18. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..b>Streptococcus pneumoniae not only is the major bacterial cause of otitis media but also causes additional life-threatening or ..
  19. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is still a major cause of morbidity and mortality around the world and its most common clonotypes are resistant to most first line antibiotics...
  20. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..important microorganisms, including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae...
  21. REGULATION OF LIPID METABOLISM IN BACTERIA
    Charles O Rock; Fiscal Year: 2013
    ..fatty acid and phospholipid synthesis in two important human pathogens: Staphylococcus aureus and Streptococcus pneumoniae. These organisms represent two major branches of lipid metabolic diversity in Gram-positive bacteria...
  22. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..TLR-1, -2, and -4 protein levels in the lungs of aged mice versus young mice;2) aged mice infected with Streptococcus pneumoniae develop fulminate pneumonia and die within 36 hours whereas young mice remain relatively healthy;3) ..
  23. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ..studies have reported the presence of antibiotic resistant Pseudomonas aerugenosa, Hemophilus influenza, Streptococcus pneumoniae and Staphylococcus aureus biofilms in the sinuses of cure resistant CRS...
  24. Coordinate regulation of competence and pneumocin production in S. pneumoniae
    SUZANNE RACHEL DAWID; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (pneumococcus) is an important human pathogen and the most common cause of bacterial meningitis, pneumonia and otitis media...
  25. Cytokine-stimulated systemic defenses during pneumococcal pneumonia
    Joseph P Mizgerd; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (pneumococcus) is the most common cause of community-acquired pneumonia...
  26. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..aureus for the anterior nares niche have focused on individual species, e.g. Staphylococcus epidermidis, Streptococcus pneumoniae, Corynebacterium spp., isolated from culture...
  27. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae is a Gram-positive bacterium that can express more than 90 different capsule types (serotypes) and is often carried as a commensal in the human nasopharynx (NPX), but can also ..
  28. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..The bacteria Streptococcus pneumoniae (SPn) have become one of the most frequent causes of pneumonia, bacteremia, and meningitis in the elderly,..
  29. Mechanisms of pneumococcal persistence during carriage.
    JEFFREY NEAL WEISER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (the pneumococus) ranks among the five leading causes of infectious death worldwide...
  30. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..among otitis prone (OP) children to infections caused by nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (Spn)...
  31. Infant Antibiotic Resistance and Implications for Therapeutic Decision-making
    SHARON MEROPOL; Fiscal Year: 2013
    ..Primary Objectives: Objective 1.1: Characterize colonization with Streptococcus pneumoniae and Staphylococcus aureus. Objective 1...
  32. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the use of antibiotics and vaccines, Streptococcus pneumoniae (pneumococcus) remains a leading cause of community acquired pneumonia and mortality...
  33. Statins protect against adverse cardiac events during pneumonia
    Carlos J Orihuela; Fiscal Year: 2012
    ..b>Streptococcus pneumoniae (the pneumococcus) is the leading cause of CAP and infectious-related death among the elderly (>65 ..
  34. Effect of the Middle Ear Inflammation On the Inner Ear
    STEVEN SUNG KYUN JUHN; Fiscal Year: 2013
    ..Widespread use of antibiotics has resulted in an increase of antibiotic-resistant Streptococcus pneumoniae and an increased potential for chronic OM development and its complications...
  35. Detection &Use of Novel Therapeutics to Stimulate NLRP3 Activity in the Elderly
    HEATHER WINONA STOUT-DELGADO; Fiscal Year: 2013
    ..It has been well established that innate and adaptive immune responses to influenza as well as Streptococcus pneumoniae are impaired with aging;however therapeutic treatments to augment these responses and thereby reduce high ..
  36. Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pylori
    MARION SHONN DORER; Fiscal Year: 2010
    ..Since lytic activities mediate competence induced predation in Streptococcus pneumoniae [9], I deleted a phage T4 lysozome homolog that is induced by DNA damage in H...
  37. The effect of a protein-lipid complex from human milk against pneumococcal otitis
    Emily Clementi; Fiscal Year: 2013
    ..b>Streptococcus pneumoniae (pneumococcal) is the most commonly isolated etiologic agent of AOM, and is also the species responsible ..
  38. Elderly Immune Response to Pneumococcal Polysaccharide
    M A JULIA WESTERINK; Fiscal Year: 2010
    b>Streptococcus pneumoniae is the leading cause of morbidity and mortality in developed as well as developing countries. Globally, pneumococcal infections have been estimated to cause 1.2 million deaths per year...
  39. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Streptococcus pneumoniae, the leading cause of pneumonia, sepsis, and meningitis worldwide, is a model for determining the ..
  40. Bacteria-Mucin Interactions at the Ocular Surface
    Ilene K Gipson; Fiscal Year: 2012
    ..Examples of the first are Staphylococcus aureus (SA) or Streptococcus pneumoniae (SPE) (encapsulated) keratitis that occurs as the result of epithelial surface damage from trauma...
  41. Vitamin D and Innate Immunity in Respiratory Infections
    Gill Diamond; Fiscal Year: 2013
    ..a mouse model of airway infection, using our existing airway infection model of intranasal inoculation of Streptococcus pneumoniae to quantify the effect of 1,25(OH)2D3 on airway host defense in vivo...
  42. Protective activity of the lectin-like domain of TNF in permeability edema
    Rudolf Lucas; Fiscal Year: 2013
    ..b>Streptococcus pneumoniae represents the main etiological agent of the disease...
  43. REGULATION OF PROTECTIVE HUMORAL IMMUNITY TO STREPTOCOCCUS PNEUMONIAE BY PD-1
    Karen M Haas; Fiscal Year: 2012
    ..to enhance protective antibody responses to pneumococcal polysaccharides (PPSs) found in the capsule of Streptococcus pneumoniae. S...
  44. Treatment of bacterial pneumonia after influenza
    Jonathan A McCullers; Fiscal Year: 2010
    ..The antibiotics most commonly used in clinical practice rapidly lyse organisms like Streptococcus pneumoniae and Staphylococcus aureus causing release of pathogen associated molecular patterns that act as triggers ..
  45. Streptococcus pneumoniae genetic competence and pathogenesis
    Michael E Sebert; Fiscal Year: 2011
    Project Summary Streptococcus pneumoniae, also known as the pneumococcus, is a bacterial pathogen that causes a range of human diseases including pneumonia, meningitis and bloodstream infections...
  46. Structural basis of tetracycline resistance by efflux pump TetL
    DANENG WANG; Fiscal Year: 2013
    ..proteins (Tet) in Gram-positive bacterial pathogens, including Bacillus anthracis, Bacillus cereus, Streptococcus pneumoniae, and Staphylococcus aureus. Clostridium spp., Enterococcus spp. and Listeria spp...
  47. Glucose regulation of bacterial virulence in diabetes and hyperglycemia
    JANET L YOTHER; Fiscal Year: 2013
    ..In this regard, the Gram-positive pathogen Streptococcus pneumoniae serves as a useful and relevant model, as: 1) diabetes and other hyperglycemic conditions lead to ..
  48. Genomic signatures for detection of upper respiratory viral infections
    Micah T McClain; Fiscal Year: 2013
    ..The PBMCs will then be exposed in vitro to live respiratory viruses (Influenza, HRV, RSV) or bacteria (Streptococcus pneumoniae, Mycoplasma, or E...
  49. Effects of neonatal microbial exposure on anti-polysaccharide B cell development
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2013
    ..provided by applicant): Gram-negative enteric infections and Gram-positive organisms, including Streptococcus pneumoniae, Group A (GAS) and Group B (GBS) streptococci are leading causes of serious bacterial infections and ..
  50. Supramolecular Complexes That Mediate Pneumococcal PG Biosynthesis and Virulence
    Malcolm E Winkler; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Streptococcus pneumoniae (pneumococcus) is an extremely serious human respiratory pathogen that kills well over two million people annually worldwide. Multidrug resistance is increasing in S...
  51. Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia
    John F Alcorn; Fiscal Year: 2013
    ..are associated with secondary bacterial infection, most commonly caused by Staphylococcus aureus or Streptococcus pneumoniae. Incidence and severity of S...
  52. Antigen processing of pneumococcal conjugate vaccines
    John R Schreiber; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Vaccines called "conjugates" against the serious pediatric pathogen Streptococcus pneumoniae (pneumococcus) have greatly reduced infections in children...
  53. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..by applicant): This is a competitive renewal application to continue studies of antibody (Ab) immunity to Streptococcus pneumoniae (pneumococcus)...
  54. HYBRID MOLECULES DESIGNED TO ENHANCE ANTIBIOTIC ACTIVITY
    George Wright; Fiscal Year: 2009
    ..Gram-positive bacteria, especially Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae, has stimulated discovery of novel agents that can selectively attack new bacterial targets...
  55. Training Grant Pediatric Infectious Diseases: Viral Infections in Children
    Yvonne A Maldonado; Fiscal Year: 2013
    ..prevention and treatment of bacterial pathogens primarily affecting infants and children, such as Streptococcus pneumoniae and Hemophilus influenzae, have resulted in the recognition of viral infections as prominent causes of ..
  56. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..The microorganisms present include Streptococcus pneumoniae, as well as bacteria not previously detected by culture-based techniques, such as Sphingomonas ..
  57. Innate and adaptive immune response to bacterial infections in COPD patients
    Yasmin Thanavala; Fiscal Year: 2009
    ..colonized, predominantly with nontypeable Haemophilus influenzae (NTHI), Moraxella catarrhalis and Streptococcus pneumoniae. Like most infections, COPD is characterized by inflammation that is mediated by the production of local ..
  58. TYPE II Enterotoxins as Mucosal Immunomodulators
    Terry D Connell; Fiscal Year: 2011
    ..adjuvants to enhance protection against pathogens [Porphyromonas gingivalis, Mycobacterium tuberculosis, Streptococcus pneumoniae] which infect different compartments (oral, respiratory, systemic) in the host...
  59. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2012
    ..by applicant): Pneumococcal surface protein A (PspA) is a leading vaccine candidate to protect against Streptococcus pneumoniae (Sp) infections...
  60. Structure and Mechanism of Metalloregulatory Proteins
    David P Giedroc; Fiscal Year: 2013
    ..approaches to elucidate determinants of metal homeostasis and cross-talk in the respiratory pathogen Streptococcus pneumoniae, focusing on zinc, manganese and copper, three metals whose concentrations change dramatically during the ..
  61. NKT cells recognize and respond to microbes at mucosal surfaces
    Dale T Umetsu; Fiscal Year: 2010
    ..NKT cells, based on strong preliminary data, we believe that many pulmonary microorganisms, including Streptococcus pneumoniae, Burkholderia cenocepacia, Sphingomonas paucimobilis and Aspergillus fumigatus express glycolipids that ..
  62. Role of Mkp-1 in pneumonia
    LYN MILLER WANCKET; Fiscal Year: 2013
    ..In this mentored research award, this hypothesis will be tested using mouse models of Streptococcus pneumoniae and influenza infection, as well as S. pneumoniae challenged primary cells...
  63. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..This lead compound cannot kill Staphylococcus aureus, Streptococcus pneumoniae, Helicobacter pylori or Haemophilus ducreyi, among other strains, in vitro...
  64. Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniae
    David S Stephens; Fiscal Year: 2010
    ..provided by applicant): The basis for the emergence of mefE-associated macrolide resistance in Streptococcus pneumoniae is a genetic element, mega (macrolide efflux genetic assembly)...
  65. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng Wang; Fiscal Year: 2009
    ..of this STTR application will demonstrate the feasibility of this approach using a pneumococcal pathogen (Streptococcus pneumoniae serotype 14) as a model. We plan to focus our efforts on the following two specific aims: 1...
  66. Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
    Cynthia Stauffacher; Fiscal Year: 2007
    ..It has recently been shown that a number of common human pathogens, including Enterococcus faecalis, Streptococcus pneumoniae and Staphylococcus aureus are dependent on enzymes in the mevalonate pathway for biosynthesis of IPP, ..
  67. 3rd ASM Conference on Cell-Cell Communication in Bacteria
    WILLIAM FUQUA; Fiscal Year: 2007
    ..might communicate with each other via chemical signals, specifically in regulating genetic competence in Streptococcus pneumoniae and in controlling bioluminescence in Vibrio fischeri, respectively...
  68. Study of S pneumoniae Virulence Gene Regulation
    Andrew Camilli; Fiscal Year: 2002
    The overall goal of our research is to understand the pathogenicity of Streptococcus pneumoniae, the most common cause of bacteremia, bacterial meningitis, otitis media and community-acquired pneumonia in the U.S.A...
  69. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..to generate recombinant, mutant collectins with improved activity against influenza A viruses (IAVs) and Streptococcus Pneumoniae (pneumococci) as compared to the wild type collectins...
  70. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..with S-IgA, lactoferrin and lysozyme against Escherichia coli O18ac:K1:H7 and the gram-positive bacteria Streptococcus pneumoniae 3 and 6B...
  71. Evaluation of zinc homeostasis mechanisms in Streptococcus pneumoniae
    FAITH ELLEN JACOBSEN; Fiscal Year: 2010
    b>Streptococcus pneumoniae is a gram positive organism that is responsible for human diseases such as pneumonia, sinusitis, meningitis and endocarditis...
  72. Pneumococcal transmission in urban environments
    Joshua Metlay; Fiscal Year: 2009
    ..investigator): Over the last century, major advances in the prevention and treatment of infections due to Streptococcus pneumoniae have been attributed to the development of antimicrobial drugs and polysaccharide vaccines...
  73. Decision Analysis of Otitis Media Vaccination Strategies
    Tracy Lieu; Fiscal Year: 2005
    ..These include new or improved vaccines against non-typeable Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and respiratory syncytial virus...
  74. DRUG DESIGN FOR TREATING OPPORTUNISTIC INFECTION IN AIDS
    Kurt Krause; Fiscal Year: 2003
    ..common opportunistic pathogens will be targeted, Mycobacterium tuberculosis, Mycobacterium avium, and Streptococcus pneumoniae, but several other pathogens will be studied as well...
  75. BIOCHEMICAL CHARACTERIZATION OF GBS HYALURONATE LYASE
    David Pritchard; Fiscal Year: 1999
    ..Similar enzymes are produced by the human pathogens Streptococcus pneumoniae and Staphylococcus aureus...
  76. A novel vaccine/adjuvant for Streptococcus pneumoniae
    M A Westerink; Fiscal Year: 2003
    ..These studies will allow us to select the immunomodulator that is optimally synergistic with F127 and provide the necessary information to advance this product to Phase II studies. ..
  77. STREPTOCOCCUS PNEUMONIAE ADHERENCE AND OTITIS MEDIA PATH
    Thomas Demaria; Fiscal Year: 2004
    ..b>Streptococcus pneumoniae (Spn), is one of the foremost human pathogens and is the primary nasopharynx, the initial event in the ..
  78. C3-Binding and -Degrading Proteins in S. pneumoniae
    MARGARET HOSTETTER; Fiscal Year: 2002
    b>Streptococcus pneumoniae remains a leading cause of morbidity and mortality in community acquired respiratory infections...