streptococcus agalactiae

Summary

Summary: A bacterium which causes mastitis in cattle and occasionally in man.

Top Publications

  1. ncbi The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30
    David G Pritchard
    Department of Biochemistry and Molecular Genetics, MCLM 552, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Microbiology 150:2079-87. 2004
  2. pmc Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
  3. ncbi The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study
    Davide Lijoi
    Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Arch Gynecol Obstet 275:373-9. 2007
  4. ncbi Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010
    Jennifer R Verani
    National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-36. 2010
  5. ncbi Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis
    Karen M Edmond
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:547-56. 2012
  6. ncbi The highly dynamic CRISPR1 system of Streptococcus agalactiae controls the diversity of its mobilome
    María José López-Sánchez
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, Paris, France
    Mol Microbiol 85:1057-71. 2012
  7. pmc Comparative genomics and the role of lateral gene transfer in the evolution of bovine adapted Streptococcus agalactiae
    Vincent P Richards
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Infect Genet Evol 11:1263-75. 2011
  8. ncbi Characterization of Streptococcus agalactiae CAMP factor as a pore-forming toxin
    Shenhui Lang
    Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 278:38167-73. 2003
  9. pmc Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis
    Joyce M Koenig
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Pediatr Clin North Am 56:689-708, Table of Contents. 2009
  10. pmc Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection
    Kimberly A Kline
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Infect Immun 79:3588-95. 2011

Research Grants

Detail Information

Publications305 found, 100 shown here

  1. ncbi The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30
    David G Pritchard
    Department of Biochemistry and Molecular Genetics, MCLM 552, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Microbiology 150:2079-87. 2004
    ..Site-directed mutagenesis of conserved cysteine and histidine residues in the CHAP domain and conserved aspartate and glutamate residues in the Acm domain confirmed their importance for lysozyme and endopeptidase activity respectively...
  2. pmc Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
    ..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
  3. ncbi The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study
    Davide Lijoi
    Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Arch Gynecol Obstet 275:373-9. 2007
    ..The aim of the current study is to evaluate the differences in the rate of perinatal group B streptococcal vertical transmission between women who correctly underwent the CDC 2002 guidelines and women who did not...
  4. ncbi Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010
    Jennifer R Verani
    National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-36. 2010
    ..In the absence of a licensed GBS vaccine, universal screening and intrapartum antibiotic prophylaxis continue to be the cornerstones of early-onset GBS disease prevention...
  5. ncbi Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis
    Karen M Edmond
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:547-56. 2012
    ..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates...
  6. ncbi The highly dynamic CRISPR1 system of Streptococcus agalactiae controls the diversity of its mobilome
    María José López-Sánchez
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, Paris, France
    Mol Microbiol 85:1057-71. 2012
    ..b>Streptococcus agalactiae, a leading cause of neonatal infections contains in its genome two CRISPR/Cas systems...
  7. pmc Comparative genomics and the role of lateral gene transfer in the evolution of bovine adapted Streptococcus agalactiae
    Vincent P Richards
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Infect Genet Evol 11:1263-75. 2011
    In addition to causing severe invasive infections in humans, Streptococcus agalactiae, or group B Streptococcus (GBS), is also a major cause of bovine mastitis. Here we provide the first genome sequence for S...
  8. ncbi Characterization of Streptococcus agalactiae CAMP factor as a pore-forming toxin
    Shenhui Lang
    Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 278:38167-73. 2003
    A recombinant form of CAMP factor of Streptococcus agalactiae has been expressed as glutathione S-transferase-CAMP fusion protein in Escherichia coli...
  9. pmc Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis
    Joyce M Koenig
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Pediatr Clin North Am 56:689-708, Table of Contents. 2009
    ..Modern technologies, such as those involving proteomics and genomic sequencing, are likely to hasten the development of a universal vaccine against GBS...
  10. pmc Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection
    Kimberly A Kline
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Infect Immun 79:3588-95. 2011
    ..These studies define several basic molecular and cellular events characterizing GBS UTI in an animal model, showing that GBS participates simultaneously in the activation and suppression of host immune responses in the urinary tract...
  11. pmc Diversity of group B streptococcus serotypes causing urinary tract infection in adults
    Kimberly B Ulett
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Clin Microbiol 47:2055-60. 2009
    ..Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS...
  12. pmc Serotype IX, a Proposed New Streptococcus agalactiae Serotype
    Hans Christian Slotved
    Neisseria and Streptococcus Reference Laboratory, Department for Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    J Clin Microbiol 45:2929-36. 2007
    We identified three isolates of Streptococcus agalactiae (group B streptococcus [GBS]), of human origin, which failed to react with antisera against any of the nine known GBS serotypes...
  13. ncbi Comparison of BD GeneOhm real-time polymerase chain reaction with chromogenic and conventional culture methods for detection of group B Streptococcus in clinical samples
    Dawn Smith
    Microbiology Department, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Diagn Microbiol Infect Dis 61:369-72. 2008
    ..5% versus 57% respectively, P < 0.02). After selective enrichment, 92.8% of GBS were isolated on chromID Strepto B compared with 89.2% isolated on sheep blood agar...
  14. ncbi The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae
    Philipp Ellinger
    Institute of Biochemistry, Heinrich Heine University, Universitatsstr 1, 40225 Dusseldorf, Germany
    J Struct Biol 178:350-62. 2012
    ..We could verify that Csn2 binds ds-DNA. In addition molecular dynamics simulations suggested a Csn2 conformation that can "sit" on the DNA helix and binds DNA in a groove on the outside of the ring...
  15. pmc Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration
    Anirban Banerjee
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, California 92182, USA
    Nat Commun 2:462. 2011
    ..Our results suggest that the bacterial pilus, specifically the PilA adhesin, has a dual role in immune activation and bacterial entry into the CNS...
  16. pmc Sudden increase in isolation of group B streptococci, serotype V, is not due to emergence of a new pulsed-field gel electrophoresis type
    J A Elliott
    Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Clin Microbiol 36:2115-6. 1998
    ..We concluded that the majority of isolates of GBS-V are of one PFGE subtype and that this subtype was predominate before the increase in disease caused by GBS-V and that GBS-V disease is caused by several different subtypes...
  17. pmc A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae
    Mathieu Brochet
    Unité de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Bacteriol 190:672-80. 2008
    ..Through DNA array analysis, we have identified two Streptococcus agalactiae strains carrying tandem genome amplifications: a fourfold amplification of 13...
  18. pmc A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80
    Krishnan Vengadesan
    Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Biol 407:731-43. 2011
    The Gram-positive pathogen Streptococcus agalactiae, known as group B Streptococcus (GBS), is the leading cause of bacterial septicemia, pneumonia, and meningitis among neonates...
  19. pmc Group B Streptococcus: global incidence and vaccine development
    Atul Kumar Johri
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Nat Rev Microbiol 4:932-42. 2006
    ..This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens...
  20. pmc Contribution of Mn-cofactored superoxide dismutase (SodA) to the virulence of Streptococcus agalactiae
    C Poyart
    INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Infect Immun 69:5098-106. 2001
    ..To analyze the role of this enzyme in the pathogenicity of GBS, we constructed a sodA-disrupted mutant of Streptococcus agalactiae NEM316 by allelic exchange...
  21. pmc The SrtA Sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine
    Lila Lalioui
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Infect Immun 73:3342-50. 2005
    b>Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal pneumonia, sepsis, and meningitis...
  22. ncbi Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease
    Scilla Buccato
    Novartis Vaccines, 1 53100 Siena, Italy
    J Infect Dis 194:331-40. 2006
    ..These data pave the way to the design of pilus-based, multivalent live vaccines against streptococcal pathogens...
  23. ncbi Evaluation of universal antenatal screening for group B streptococcus
    Melissa K Van Dyke
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 360:2626-36. 2009
    ..In 2002, national guidelines recommended universal late antenatal screening of pregnant women for colonization with group B streptococcus to identify candidates for intrapartum chemoprophylaxis...
  24. ncbi Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007
    Tami H Skoff
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:85-92. 2009
    ..We used population-based surveillance to examine trends in adult GBS disease during the period 1990-2007 and to describe the epidemiology of adult GBS disease to guide prevention efforts...
  25. pmc The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
    Asmaa Tazi
    Institut Cochin, Université Paris Descartes Faculté de Médecine, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France
    J Exp Med 207:2313-22. 2010
    b>Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis...
  26. pmc Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins
    Izabela Sitkiewicz
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    BMC Microbiol 11:65. 2011
    ..Ten RD2-encoded proteins have significant similarity to proteins involved in conjugative transfer of Streptococcus thermophilus integrative chromosomal elements (ICEs)...
  27. ncbi Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Infect Dis 185:196-203. 2002
    ..These data indicate that the GBS beta-h/c contributes to invasion and immune activation of lung epithelial cells and may represent a multifunctional virulence factor in the early pulmonary stages of GBS infection...
  28. pmc Invasive group B streptococcal infections in infants, France
    Claire Poyart
    Institut National de la Sante et de la Recherche Medicale, U567, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 810, Paris, France
    Emerg Infect Dis 14:1647-9. 2008
    ..Sixty-four percent of the strains were from late-onset infections, and 75% were capsular type III. The hypervirulent clone ST-17 was recovered in 80% of meningitis cases...
  29. ncbi Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm
    Immaculada Margarit
    Novartis Vaccines, Siena, Italy
    J Infect Dis 199:108-15. 2009
    ..the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit ..
  30. ncbi Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005
    Christina R Phares
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    JAMA 299:2056-65. 2008
    ..Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development...
  31. pmc Multilocus sequence types associated with neonatal group B streptococcal sepsis and meningitis in Canada
    Shannon D Manning
    Department ofPediatrics and Human Development, Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, E Lansing, Michigan 48824, USA
    J Clin Microbiol 47:1143-8. 2009
    ..Further research is required to better understand why strains belonging to the ST-17 phylogenetic lineage are more likely to cause both LOD and meningitis and may provide clues into the pathogenesis of these conditions...
  32. pmc Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides
    Andrea Hamilton
    Department of Pediatrics, University of Washington, and Children s Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, USA
    Infect Immun 74:6179-87. 2006
    ..While the peptidoglycan polymerization and cross-linking activity of PBPs are essential for bacterial survival, our study is the first to identify a role for a PBP in resistance to host AMPs...
  33. pmc The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity
    Magali Bebien
    Centre d Immunologie de Marseille Luminy CIML, Aix Marseille University, UM2, Marseille, France
    PLoS Pathog 8:e1002812. 2012
    ..Our studies suggest p38 MAPK may represent a new therapeutic target to blunt virulence and improve clinical outcome of invasive GBS infection...
  34. ncbi Group B streptococcal disease in infants: progress in prevention and continued challenges
    Jennifer R Verani
    Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS C 23, Atlanta, GA 30333, USA
    Clin Perinatol 37:375-92. 2010
    ..This article discusses implementation challenges for clinicians caring for pregnant women and newborns and presents an updated algorithm for neonatal management...
  35. pmc Sortase A substrate specificity in GBS pilus 2a cell wall anchoring
    Francesca Necchi
    Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 6:e25300. 2011
    b>Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS), is one of the most common causes of life-threatening bacterial infections in infants...
  36. pmc NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA
    Sachin D Deshmukh
    Center of Chronic Immunodeficiency, University of Freiburg, 79106 Freiburg, Germany
    J Immunol 188:774-80. 2012
    ..This NO-dependent amplification loop has important mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesis...
  37. ncbi Neonatal sepsis workups in infants >/=2000 grams at birth: A population-based study
    G J Escobar
    Kaiser Permanente Medical Care Program, Division of Research, Perinatal Research Unit, Oakland, California 94611, USA
    Pediatrics 106:256-63. 2000
    ..Few data are available on the outcome of neonatal sepsis evaluations in an era when intrapartum antibiotic therapy is common...
  38. pmc Group B streptococcus serotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distribution
    Danielle L Ippolito
    Department of Clinical Investigation, Madigan Healthcare System, 9040 Reid St, Tacoma, WA 98431, USA
    BMC Infect Dis 10:336. 2010
    ....
  39. pmc Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiae
    Annabelle Fernandez
    Institut National de la Recherche Agronomique, UMR1319 MICALIS, Bâtiment 222, Domaine de Vilvert, Jouy en Josas, France
    PLoS Pathog 6:e1000860. 2010
    b>Streptococcus agalactiae is a major neonatal pathogen whose infectious route involves septicemia...
  40. ncbi The prevention of early-onset neonatal group B streptococcal disease
    Deborah M Money
    J Obstet Gynaecol Can 26:826-40. 2004
    ..To review the evidence in the literature and to provide recommendations on the management of pregnant women in labour for the prevention of early-onset neonatal group B streptococcal (GBS) disease...
  41. ncbi Molecular characterization of capsular polysaccharides and surface protein genes in relation to genetic similarity of group B streptococci isolated from Polish pregnant women
    M Brzychczy-Włoch
    Department of Bacteriology, Microbial Ecology and Parasitology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland
    Epidemiol Infect 140:329-36. 2012
    ..The distribution of serotypes and surface proteins of GBS strains are necessary data to inform the design and formulation of new GBS vaccines for use in Poland and other countries...
  42. pmc Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci
    J L Michel
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 89:10060-4. 1992
    ..The large region of identical repeating units in bca defines protective epitopes and may play a role in generating phenotypic and genotypic diversity of the alpha antigen...
  43. ncbi IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
    Nature 434:1138-43. 2005
    ..Inactivation of IKKalpha in mice enhances inflammation and bacterial clearance. Hence, the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity...
  44. pmc Streptococcus agalactiae in adults at Chiang Mai University Hospital: a retrospective study
    Romanee Chaiwarith
    Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    BMC Infect Dis 11:149. 2011
    Infection caused by Streptococcus agalactiae, a Group B streptococcus, is an emerging disease in non-pregnant adults. This study describes the epidemiological, clinical, and microbiological characteristics of S...
  45. pmc Detection of group B streptococci in Lim broth by use of group B streptococcus peptide nucleic acid fluorescent in situ hybridization and selective and nonselective agars
    Naomi S Montague
    Department of Pathology, Jackson Memorial Hospital, and the University of Miami Miller School of Medicine, Miami, Florida, USA
    J Clin Microbiol 46:3470-2. 2008
    ..4%, 100%, 100%, and 87.9%, respectively; for culture on SSA, 85.5%, 100%, 100%, and 94.1%, respectively; and for the PNA FISH assay, 97.4%, 98.3%, 96.1%, and 98.9%, respectively...
  46. ncbi Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease
    Giuseppe Mancuso
    Department of Pathology and Experimental Microbiology, University of Messina Medical School, Messina, Italy
    J Immunol 172:6324-9. 2004
    ..In conclusion, these data highlight a dual role of TLR2 and MyD88 in the host defense against GBS sepsis and strongly suggest TNF-alpha as the molecular mediator of bacterial clearance and septic shock...
  47. pmc Invasive group B streptococcal infection in infants, Malawi
    Katherine J Gray
    Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi
    Emerg Infect Dis 13:223-9. 2007
    ..Effective locally relevant prevention strategies are needed...
  48. pmc Identification of Streptococcus agalactiae isolates from various phylogenetic lineages by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    Marie Frédérique Lartigue
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno foetal, Tours, France
    J Clin Microbiol 47:2284-7. 2009
    ..Using this method, we identified 110 Streptococcus agalactiae isolates characterized by serotyping and multilocus sequence typing...
  49. ncbi [Invasive Streptococcus agalactiae infections in non-pregnant adults]
    N Lefebvre
    Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Strasbourg, 1, Place de l Hopital, 67091 Strasbourg Cedex, France
    Med Mal Infect 37:796-801. 2007
    b>Streptococcus agalactiae (Group B streptococcus) is a major cause of invasive diseases in non-pregnant adults, particularly in the elderly and those with underlying conditions...
  50. ncbi Rga, a RofA-like regulator, is the major transcriptional activator of the PI-2a pilus in Streptococcus agalactiae
    Shaynoor Dramsi
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, Paris, France
    Microb Drug Resist 18:286-97. 2012
    ..environments is key in determining the outcome of infections caused by the opportunistic human pathogen Streptococcus agalactiae. We previously demonstrated that the RofA-like protein (RALP) regulators RogB and Rga activate their ..
  51. ncbi Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany
    Mirjam Kunze
    Department of Obstetrics and Gynecology, University Hospital Freiburg, Freiburg, Germany
    J Perinat Med 39:417-22. 2011
    ..To evaluate colonization, transmission rate and serotype distribution of group B streptococci (GBS) in pregnant women and infants born in a single University Center in Germany...
  52. pmc Comparison of carrot broth- and selective Todd-Hewitt broth-enhanced PCR protocols for real-time detection of Streptococcus agalactiae in prenatal vaginal/anorectal specimens
    Timothy Block
    Wheaton Franciscan Laboratory, 11020 West Plank Court, Suite 100, Wauwatosa, WI 53226, USA
    J Clin Microbiol 46:3615-20. 2008
    The reporting of accurate Streptococcus agalactiae screening results in a short time frame is of tremendous clinical benefit...
  53. ncbi [Polish Gynecological Society's recommendations regarding diagnosis and prevention of streptococcus agalactiae infection in pregnant women and newborns]
    Jan Kotarski
    Katedra Mikrobiologii CM UJ w Krakowie
    Ginekol Pol 79:221-3. 2008
  54. ncbi Late and ultra late onset Streptococcus B meningitis: clinical and bacteriological data over 6 years in France
    J Guilbert
    Department of Paediatric Intensive Care Unit, Trousseau s Hospital, Paris, France
    Acta Paediatr 99:47-51. 2010
    ....
  55. ncbi Comparison of rapid intrapartum screening methods for group B streptococcal vaginal colonization
    Natali Aziz
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94025, USA
    J Matern Fetal Neonatal Med 18:225-9. 2005
    ..To compare optical immunoassay (OIA) and rapid polymerase-chain reaction (PCR) with enrichment broth culture for intrapartum detection of vaginal group B streptococcal (GBS) colonization...
  56. pmc Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract
    Tamsin R Sheen
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA
    J Bacteriol 193:6834-42. 2011
    b>Streptococcus agalactiae (group B streptococcus [GBS]) is a Gram-positive bacterium found in the female rectovaginal tract and is capable of producing severe disease in susceptible hosts, including newborns and pregnant women...
  57. pmc Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulence
    Michel Yves Mistou
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, Paris Cedex 15, France
    J Bacteriol 191:4195-206. 2009
    ..The secA2 locus of Streptococcus agalactiae strain NEM316 is structurally related to those found in other streptococci and encodes the serine-rich ..
  58. ncbi Neonatal group B streptococcal disease: from pathogenesis to preventive strategies
    P Melin
    National Reference Centre for Group B Streptococci, Medical Microbiology Department, University Hospital of Liege, Liege, Belgium
    Clin Microbiol Infect 17:1294-303. 2011
    b>Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, as early-onset or late-onset diseases (EOD, LOD)...
  59. ncbi Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1alpha
    Glen C Ulett
    Departments of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Infect Dis 201:866-70. 2010
    ..Thus, binding of uropathogenic GBS to uroepithelium and vigorous induction of interleukin 1alpha represents the initial stages of GBS urinary tract infection...
  60. pmc A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping
    Eve Haguenoer
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
    BMC Microbiol 11:171. 2011
    Multilocus sequence typing (MLST) is currently the reference method for genotyping Streptococcus agalactiae strains, the leading cause of infectious disease in newborns and a major cause of disease in immunocompromised children and adults...
  61. pmc Adherence to perinatal group B streptococcal prevention guidelines
    William P Goins
    Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Obstet Gynecol 115:1217-24. 2010
    ....
  62. ncbi Mechanisms of group B streptococcal-induced apoptosis of murine macrophages
    Glen C Ulett
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 175:2555-62. 2005
    Apoptosis of murine and human macrophages induced by group B Streptococcus agalactiae (GBS) is likely an important virulence mechanism that is used by the bacteria to suppress the host immune response and to persist at sites of infection...
  63. pmc Group B streptococcal disease in nonpregnant patients: emergence of highly resistant strains of serotype Ib in Taiwan in 2006 to 2008
    Ying Hsiang Wang
    Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, Taiwan
    J Clin Microbiol 48:2571-4. 2010
    ..Serotype Ib isolates (24.6%) were the second most prevalent serotype, next to serotype V (29.4%), and showed the highest resistance rates to erythromycin (91.0%) and clindamycin (82.1%)...
  64. pmc The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages
    Nicola J Cumley
    School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Infect Immun 80:1650-61. 2012
    ..Moreover, we show that the GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome...
  65. ncbi Group B Streptococcus surface proteins as major determinants for meningeal tropism
    Asmaa Tazi
    Institut Cochin, Université Paris Descartes Sorbonne Paris Cité, CNRS UMR 8104, Paris, France
    Curr Opin Microbiol 15:44-9. 2012
    b>Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with ..
  66. pmc CAMP factor is not essential for systemic virulence of Group B Streptococcus
    Mary E Hensler
    Division of Pediatric Pharmacology and Drug Discovery, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    Microb Pathog 44:84-8. 2008
    ..Our data suggest that CAMP factor expressed in its native context is not essential for systemic virulence of GBS...
  67. ncbi Focal adhesion kinase is involved in type III group B streptococcal invasion of human brain microvascular endothelial cells
    Sooan Shin
    Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Park 256, Baltimore, MD 21287, USA
    Microb Pathog 41:168-73. 2006
    ..This is the first demonstration that FAK phosphorylation and its association with paxillin and PI3 kinase play a key role in type III GBS invasion of HBMEC...
  68. ncbi The prevalence of streptococcus agalactiae (group B) colonization in pregnant women at Thammasat Hospital
    Siripen Tor-Udom
    Department of Microbiology, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12121, Thailand
    J Med Assoc Thai 89:411-4. 2006
    ..Group B Streptococci (GBS) is responsible for serious infections in newborns such as septicemia and meningitis...
  69. pmc The cell lysis activity of the Streptococcus agalactiae bacteriophage B30 endolysin relies on the cysteine, histidine-dependent amidohydrolase/peptidase domain
    David M Donovan
    Biotechnology and Germplasm Laboratory, ANRI, ARS, USDA, Bldg 230, Room 104, BARC East, 10300 Baltimore Ave, Beltsville, MD 20705 23501, USA
    Appl Environ Microbiol 72:5108-12. 2006
    The Streptococcus agalactiae bacteriophage B30 endolysin contains three domains: cysteine, histidine-dependent amidohydrolase/peptidase (CHAP), Acm glycosidase, and the SH3b cell wall binding domain...
  70. ncbi Genome analysis reveals pili in Group B Streptococcus
    Peter Lauer
    Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
    Science 309:105. 2005
    ..Immunogold electron microscopy revealed that the structures have a pilus-like form. These large structures have gone unrecognized in decades of studies of Group B Streptococcus...
  71. pmc Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion
    Mika K Rantanen
    Institute of Biotechnology, University of Helsinki, Finland, and Division of Infectious Disease, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    FEBS J 274:3128-37. 2007
    We solved the crystal structure of Streptococcus agalactiae serine/threonine phosphatase (SaSTP) using a combination of single-wavelength anomalous dispersion phasing and molecular replacement...
  72. ncbi Functional analysis of a PcsB-deficient mutant of group B streptococcus
    Dieter J Reinscheid
    Department of Microbiology and Biotechnology, University of Ulm, D 89069 Ulm, Germany
    FEMS Microbiol Lett 221:73-9. 2003
    ..Northern blot analysis exhibited similar expression of the enolase gene in the GBS strains 6313 and Sep1, indicating that mutant Sep1 is impaired in the anchoring of this protein to its cell wall...
  73. ncbi Bioinformatic insights into the biosynthesis of the Group B carbohydrate in Streptococcus agalactiae
    Iain C Sutcliffe
    Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Microbiology 154:1354-63. 2008
    b>Streptococcus agalactiae is a major human and animal pathogen, most notable as a cause of life-threatening disease in neonates. S...
  74. ncbi Choriodecidual inflammation: a harbinger of the preterm labor syndrome
    Peta L Grigsby
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Reprod Sci 17:85-94. 2010
    ....
  75. pmc Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus
    Cira Daniela Rinaudo
    Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 5:e9216. 2010
    b>Streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis...
  76. pmc Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration
    Annalisa Lembo
    Department of Pediatric Infectious Diseases, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Microbiol 77:431-43. 2010
    ....
  77. pmc Molecular characterization and prophage DNA contents of Streptococcus agalactiae strains isolated from adult skin and osteoarticular infections
    Mazen Salloum
    Equipe d Accueil 3854, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, UFR Medecine, Universite Francois Rabelais de Tours, 37032 Tours Cedex, France
    J Clin Microbiol 48:1261-9. 2010
    Skin and osteoarticular infections (SKI and OAI, respectively) account for almost one-third of Streptococcus agalactiae infections in nonpregnant adults. We evaluated the genetic diversity and phylogeny of 58 S...
  78. pmc Enhanced expression of lmb gene encoding laminin-binding protein in Streptococcus agalactiae strains harboring IS1548 in scpB-lmb intergenic region
    Rim Al Safadi
    Equipe d Accueil 3854 Bactéries et Risque Materno Foetal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, UFR Medecine, Universite Francois Rabelais de Tours, Tours, France
    PLoS ONE 5:e10794. 2010
    ....
  79. pmc Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin
    B Spellerberg
    Institute of Medical Microbiology, University Hospital Aachen, D 52057 Aachen, Germany
    Infect Immun 67:871-8. 1999
    b>Streptococcus agalactiae is a leading cause of neonatal sepsis and meningitis...
  80. pmc Structural and genetic diversity of group B streptococcus capsular polysaccharides
    Michael J Cieslewicz
    Division of Infectious Diseases, Children s Hospital, University of Washington, Seattle, WA 98109, USA
    Infect Immun 73:3096-103. 2005
    ....
  81. ncbi Morbidity related to maternal group B streptococcal infections
    Anouk E Muller
    Department of Obstetrics and Gynecology, Medical Centre Haaglanden, The Hague, The Netherlands
    Acta Obstet Gynecol Scand 85:1027-37. 2006
    ..We describe the various maternal group B streptococcal infections, their characteristics, associated neonatal morbidity, and prevention and treatment strategies during pregnancy, delivery, and in the postpartum period...
  82. pmc Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system
    C Poyart
    Laboratoire de Microbiologie, INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    J Bacteriol 183:6324-34. 2001
    ..In this work, we characterized the dlt operon of Streptococcus agalactiae, which, in addition to the dltA to dltD genes, included two regulatory genes, designated dltR and dltS, ..
  83. pmc CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development
    Isabella Santi
    Novartis Vaccines and Diagnostics Srl, Via Fiorentina 1, 53100 Siena, Italy
    J Bacteriol 191:5387-97. 2009
    ..0 induced opsonophagocytic killing of GBS in immune serum highlights the importance of pH regulation in the protective efficacy of specific antibodies to surface-exposed GBS proteins...
  84. pmc The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses
    Darin Quach
    Department of Biology and Center for Microbial Sciences, San Diego State University, CA 92182, USA
    J Bacteriol 191:2023-32. 2009
    ..Our results identify the GBS CiaR response regulator as a crucial factor in GBS intracellular survival and invasive disease pathogenesis...
  85. ncbi Assembly and role of pili in group B streptococci
    Shaynoor Dramsi
    Unité de Biologie des Bactéries Pathogènes à Gram Positif Institut Pasteur, URA CNRS 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 60:1401-13. 2006
    b>Streptococcus agalactiae[group B streptococcus (GBS)] is the leading cause of neonatal pneumonia, sepsis and meningitis...
  86. ncbi Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein
    Pedro Madureira
    ICBAS Instituto de Ciências Biomédicas de Abel Salazar, Porto, Portugal
    J Immunol 178:1379-87. 2007
    ..In this study, a protein with B lymphocyte stimulatory activity was isolated from culture supernatants of Streptococcus agalactiae strain NEM316...
  87. pmc Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999
    John F Bohnsack
    University of Utah Health Sciences Center, Department of Pediatrics, 50 North Medical Dr, Salt Lake City, UT 84132, USA
    J Clin Microbiol 46:1285-91. 2008
    ..7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates...
  88. ncbi Horizontal gene transfer and host specificity of beta-haemolytic streptococci: the role of a putative composite transposon containing scpB and lmb
    C Franken
    Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Mol Microbiol 41:925-35. 2001
    ..The surface protein, Lmb, mediates the adherence of Streptococcus agalactiae to human laminin...
  89. pmc The transcriptional regulator RovS controls the attachment of Streptococcus agalactiae to human epithelial cells and the expression of virulence genes
    Ulrike M Samen
    Department of Microbiology and Biotechnology, University of Ulm, Albert Einstein Allee 11, D 89069 Ulm, Germany
    Infect Immun 74:5625-35. 2006
    b>Streptococcus agalactiae is part of the normal flora of the human gastrointestinal tract and also the leading cause of bacterial infections in human newborns and immunocompromised adults...
  90. ncbi A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites
    Axel Schubert
    Department of Microbiology and Biotechnology, University of Ulm, Germany
    Mol Microbiol 46:557-69. 2002
    ....
  91. ncbi Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase: surface localization, enzymatic activity, and protein-protein interactions
    Kyle N Seifert
    Department of Oral Biology, College of Dentistry, University of Florida, Gainsville, FL 32610 0424, USA
    Can J Microbiol 49:350-6. 2003
    ..Enzymatically active GAPDH, capable of binding cytoskeletal and extracellular matrix proteins, is expressed on the surface of GBS...
  92. pmc Multilocus sequence typing system for group B streptococcus
    Nicola Jones
    Nuffield Department of Clinical Laboratory Sciences, Institute for Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 41:2530-6. 2003
    ..A web site for GBS MLST was set up and can be accessed at http://sagalactiae.mlst.net. The GBS MLST system offers investigators a valuable typing tool that will promote further investigation of the population biology of this organism...
  93. pmc The Delta subunit of RNA polymerase is required for virulence of Streptococcus agalactiae
    Amanda L Jones
    Department of Pediatrics, Division of Infectious Diseases, Children s Hospital and Regional Medical Center and University of Washington, Seattle, Washington 98105, USA
    Infect Immun 71:4011-7. 2003
    ..Our data represent the first report of a phenotype relevant to virulence for rpoE mutants...
  94. ncbi Comparative evaluation of Strepto B ID chromogenic medium and Granada media for the detection of Group B streptococcus from vaginal samples of pregnant women
    Asmaa Tazi
    Service de Bacteriologie, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre National de Référence des Streptocoques, Paris, France
    J Microbiol Methods 73:263-5. 2008
    ..All tested media were comparable in terms of sensitivity however, their use in routine laboratories may markedly facilitate the rapid detection of GBS in vaginal samples...
  95. pmc Epidemiology of and prenatal molecular distinction between invasive and colonizing group B streptococci in The Netherlands and Taiwan
    E van Elzakker
    Department of Microbiology, Haga Hospital, PO Box 40551, 2504 LN, The Hague, The Netherlands
    Eur J Clin Microbiol Infect Dis 28:921-8. 2009
    ..826-0.963). PPI-specific and serological markers can distinguish local neonatal invasive GBS strains from colonizing ones. Apparently, there are clear regional differences in the GBS epidemiology and infection potential of clones...
  96. pmc Understanding the regulation of Group B Streptococcal virulence factors
    Lakshmi Rajagopal
    Department of Pediatric Infectious Diseases, University of Washington and Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101 91304, USA
    Future Microbiol 4:201-21. 2009
    ..Consequently, understanding signaling responses of GBS is essential for elucidation of pathogenesis of GBS infection and for the identification of novel therapeutic agents...
  97. pmc Latex assay for serotyping of group B Streptococcus isolates
    H C Slotved
    Production Unit, Department of Respiratory Infections, Meningitis and STIs, Division of Microbiology, Statens Serum Institut, Copenhagen, Denmark
    J Clin Microbiol 41:4445-7. 2003
    ..A total of 232 isolates were tested, and 203 isolates were serotyped by the GBS latex test, while the capillary precipitation test serotyped 184 isolates...
  98. pmc Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae
    Yoan Konto-Ghiorghi
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif and URA CNRS 2172, Paris, France
    PLoS Pathog 5:e1000422. 2009
    b>Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process...
  99. ncbi Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells
    Alfredo Pezzicoli
    Novartis Vaccines and Diagnostics, Siena, Italy
    J Infect Dis 198:890-8. 2008
    ..These findings suggest a dual role for pilus components during the critical steps leading to GBS dissemination in the host...
  100. ncbi Streptococcus agalactiae invasion of human brain microvascular endothelial cells is promoted by the laminin-binding protein Lmb
    Tobias Tenenbaum
    Pädiatrische Infektiologie, Klinik fur Allgemeine Padiatrie, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Microbes Infect 9:714-20. 2007
    b>Streptococcus agalactiae (S. agalactiae) can cause severe pneumonia, sepsis and meningitis in neonates and remains one of the most prevalent causes of invasive neonatal infections. During the course of infection, S...
  101. pmc Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5
    Aaron F Carlin
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 206:1691-9. 2009
    ..We conclude that protein-mediated functional engagement of an inhibitory host lectin receptor promotes bacterial innate immune evasion...

Research Grants58

  1. Analysis of Group B Streptococcal Fibrinogen Cleavage
    Daniel Shelver; Fiscal Year: 2005
    ..The availability of the purified protein will facilitate future biochemical structure-function studies on this important virulence factor of GBS. ..
  2. GROUP B STREPTOCOCCAL SURFACE PROTEINS IN IMMUNE EVASION
    LAWRENCE MADOFF; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary: This project on group B Streptococcus (Streptococcus agalactiae) focuses on a class of key surface proteins called alpha-like proteins that are also found on a variety of ..
  3. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae. A[unreadable] is a more potent antimicrobial agent than LL-37 for at least two of these microorganisms...
  4. MtaR-regulated virulence in Streptococcus agalactiae
    Daniel Shelver; Fiscal Year: 2009
    DESCRIPTION (provided by applicant). Streptococcus agalactiae (group B Streptococcus;GBS) is a leading cause of invasive infections such as pneumonia, sepsis, and meningitis in neonates...
  5. MOLECULAR MECHANISMS OF FIBRINOLYSIS
    Paul E Bock; Fiscal Year: 2013
    ..cofactor of tPA-catalyzed Pg activation, and to evaluate its potential role as pathogenicity factor in Streptococcus agalactiae infections...
  6. Pilus Assembly in Gram-Positive Bacteria
    Hung Ton That; Fiscal Year: 2010
    ..We will determine, by biochemical and microscopic methods, whether Streptococcus agalactiae employes the same mechanism for pilus assembly...
  7. COMPARATIVE ANALYSIS OF GROUP A AND B STREPTOCCAL GENOME
    JOSEPH FERRETTI; Fiscal Year: 2000
    ..initiated a project to establish a physical and genetic map of the group B streptococcal genome (GBS, Streptococcus agalactiae)...
  8. Quorum Sensing in Group B Streptococcus
    MICHAEL CIESLEWICZ; Fiscal Year: 2006
    Group B Streptococcus (Streptococcus agalactiae or GBS) is the leading cause of gram positive neonatal meningitis and is an increasingly important cause of serious infection in elderly and chronically ill adults...
  9. Group B Streptococcal Surface Proteins Immune Evasion
    LAWRENCE MADOFF; Fiscal Year: 2005
    Group B Streptococcus (Streptococcus agalactiae) remains a major cause of death and serious illness in newborn babies and has emerged as an important pathogen in immunocompromised adults...
  10. NATURAL ANTIBODY AGAINST GROUP B STREPTOCCOUS IN MICE
    Peter Butko; Fiscal Year: 2001
    DESCRIPTION (Verbatim from Applicant's Abstract): Group B streptococcus (GBS, Streptococcus agalactiae) is the most common cause of neonatal sepsis and meningitis in the USA...
  11. NEW POTENTIAL VIRULENCE FACTOR IN E FAECALIS
    Nathan Shankar; Fiscal Year: 2001
    ..Employing this approach, a highly conserved homolog of Streptococcus agalactiae C alpha protein antigen has been identified in a clinical isolate of E. faecalis. The C proteins of S...
  12. Multiplex Prenatal Screen for Perinatal Pathogens
    Heather Kiefer; Fiscal Year: 2004
    ..acid-based multiplex test for the detection and quantification of the most common perinatal pathogens; Streptococcus agalactiae (group B streptococcus), Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex virus 1 and 2...
  13. Development of a Global GBS Vaccine
    LAWRENCE PAOLETTI; Fiscal Year: 2007
    ..This work will lead to a vaccine effective in preventing GBS diseases worldwide. ..
  14. Bacterial Vaccine Antigen Discovery
    LAWRENCE PAOLETTI; Fiscal Year: 2006
    ..Aim 2). Findings from these studies utilizing this unique approach to vaccine antigen discovery could be directly applied to other bacterial pathogens. ..
  15. Mechanisms of Tandem Repeat Deletion in Group B Strep
    KAREN PUOPOLO; Fiscal Year: 2006
    ..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
  16. GENETIC ANALYSIS OF GBS ADHERENCE TO FIBRONECTIN
    GLEN TAMURA; Fiscal Year: 2002
    ..These studies will allow for identification of the structural gene(s) for fibronectin adhesin(s). ..
  17. MATERNAL IMMUNIZATION TO PREVENT INFANT OTITIS MEDIA
    Patricia Ferrieri; Fiscal Year: 2005
    ..Results of this trial will have a profound impact on the broad field of maternal immunization to prevent early infant disease caused by a variety of infant bacterial and viral pathogens. ..
  18. GBS: Epidemiologic Characterization for Gene Discovery
    Betsy Foxman; Fiscal Year: 2007
    ..A better understanding of the molecular epidemiology and the identification of new GBS virulence genes will facilitate the discover of new therapies and prevention strategies for GBS disease. ..
  19. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 2001
    ..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..
  20. Oral and Vaginal Microbes, Human Genotype, and Preterm Birth
    Dawn P Misra; Fiscal Year: 2010
    ..For this proposal we have the great advantage of exploring these hypotheses using already collected specimens and data as part of completed studies of preterm birth. ..
  21. Group B Strep Alp Protein-Epithelial Cell Interaction
    MIRIAM BARON BARSHAK; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. Lateral flow assay for detecting colonization by Streptococcus agalactiae
    Ying Li; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Streptococcus agalactiae, a.k.a. group B streptococcus (GBS), is one of the leading causes of morbidity, and mortality among newborns...
  23. Inhibition of GBS Carriage by Engineered Lactobacilli
    David Pritchard; Fiscal Year: 2004
    ..If successful, this approach might also be used to protect against other genital, oral, and intestinal pathogens, especially those to which no effective mucosal immunity appears to develop. ..
  24. B. anthracis Peptidoglycan Deacetylase as a Drug Target
    David Pritchard; Fiscal Year: 2005
    ..anthracis, by inhibiting the deacetylases which specifically render their cell wall peptidoglycans resistant to the action of lysozyme. ..
  25. Role of penicillin binding protein 1a in GBS virulence
    Amanda Jones; Fiscal Year: 2006
    ..abstract_text> ..
  26. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    ..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
  27. Genetic Diversity and Molecular Epidemiology of GBS
    HERBERT DAVIES; Fiscal Year: 2008
    ..In addition, the assessment of colonizing GBS strains will provide fundamental insights into the nature of GBS colonization, which is the critical first step preceding neonatal transmission, infection and disease. ..
  28. INTRACELLULAR INFECTION BY INVASIVE GROUP A STREPTOCOCCI
    Paul Cleary; Fiscal Year: 2006
    ..Information gained from this study may identify new targets for antibiotic development, and increase our understanding of the mechanisms by which this pathogen persists in human populations. ..
  29. Structural determinants of human immunity to anthrax
    Donald Reason; Fiscal Year: 2008
    ..anthracis infection. In addition, the antibodies isolated will constitute a panel of fully human monoclonal binding domains with potential for therapeutic use as passive immunogens. [unreadable] [unreadable] [unreadable]..
  30. GENETICS OF VIRULENCE OF TYPE III GROUP B STREPTOCOCCUS
    Craig Rubens; Fiscal Year: 2003
    ..They may also provide clues to the evolution of new GBS serotypes which are now causing human infections. ..
  31. Microfluidic system for point of care diagnosis of GBS
    Michel Bergeron; Fiscal Year: 2008
    ..Moreover, this technology could also be applicable to the detection of other infectious disease agents including biological warfare agents. ..
  32. Srv is critical for Streptococcal survival in the host
    SEAN REID; Fiscal Year: 2009
    ..Understanding the mechanism of Srv-dependent gene regulation will provide new insights into the control of GAS disease. ..
  33. Role of Bacterial Vaginosis in Preterm Delivery
    ROBIN ROSS; Fiscal Year: 2003
    ..Bacterial factors produced during coculture will be determined and correlated with stimulation of an inflammatory response. Due to the novelty of the models, we have the unique opportunity to determine the role of BVAF in PTD. ..
  34. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  35. STREPTOCOCCAL INACTIVATOR IN HUMAN CHEMOATTRACTANTS
    Paul Cleary; Fiscal Year: 2006
    ..New data indicates that the C5a peptide required for successful colonization and persistence of streptococci in nasal associated lymphoid tissue. ..
  36. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  37. Neutrophil Apoptosis and Neonatal Inflammation
    JOYCE KOENIG; Fiscal Year: 2009
    ..Thus, defining the biology of neutrophil apoptosis in the developing human is critical to future treatment modalities for CLD and other types of neonatal inflammation. ..
  38. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  39. A RANDOMIZED CONTROLLED TRIAL OF ECHINACEA IN CHILDREN
    James Taylor; Fiscal Year: 2001
    ..abstract_text> ..
  40. MOLECULAR MECHANISMS OF THE HUMORAL IMMUNE RESPONSE
    CLIFFORD SNAPPER; Fiscal Year: 2001
    ..These studies will elucidate key parameters that underlie the molecular basis of Ig switching. ..
  41. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  42. DENDRITIC AND T CELLS IN ANTI-BACTERIAL lg RESPONSES
    Clifford M Snapper; Fiscal Year: 2010
    ..abstract_text> ..
  43. Human monoclonal panel mimicking anthrax immune globulin
    Donald Reason; Fiscal Year: 2005
    ..The PA-specific panel we construct will be molecularly defined and characterized, incorporate the advantages of toxin-specific, polyclonal human sera, and lack the inherent risk associated with blood derived products. ..
  44. Cardiac Depression in Gram-Positive Sepsis--Role of TLR2
    Jesus Vallejo; Fiscal Year: 2005
    ..These studies will provide definitive new information with respect to the mechanisms responsible for the deleterious effects of gram-positive sepsis on cardiac function and structure. ..
  45. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
  46. The Feasibility of Assessing the Prevalence of Rickets
    James Taylor; Fiscal Year: 2006
    ..In addition to assessing possible methodologies for the larger project, the preliminary study is designed to yield standalone results with important implications. [unreadable] [unreadable] [unreadable]..
  47. In Utero Infection: Child Health and Neurodevelopment
    William Andrews; Fiscal Year: 2005
    ..abstract_text> ..
  48. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  49. B7 COSTIMULATION RESPONSE TO EXTRACELLULAR BACTERIA
    CLIFFORD SNAPPER; Fiscal Year: 2004
    ..These experiments will provide insight into the mechanism of why B7-1 vs. B7-2 blockade differentially influences the R36A response. ..
  50. Role of a novel signal transduction pathway in GBS
    Craig Rubens; Fiscal Year: 2007
    The gram-positive pathogen Streptococcus agalactiae (group B streptococci, GBS) is the principal cause of human neonatal pneumonia, sepsis and meningitis. GBS is also an emerging pathogen of immunocompromised adults...
  51. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  52. MOLECULAR DETERMINANTS OF HUMAN PNEUMOCOCCAL IMMUNITY
    Donald Reason; Fiscal Year: 2004
    ..Understanding the molecular mechanisms that shape the human antibody repertoire to pneumococcal polysaccharides may also suggest strategies that would facilitate the development of more efficacious vaccines. ..
  53. Genome Analysis of Streptococcus agalactiae
    Herve Tettelin; Fiscal Year: 2002
    Group B streptococci (GBS) or Streptococcus agalactiae are weakly beta-hemolytic, facultatively anaerobic Gram-positive cocci, which have emerged over the past 50 years as the most significant bacterial cause of neonatal sepsis, pneumonia,..
  54. T cell immune response to group A streptococci in NALT
    Paul Cleary; Fiscal Year: 2008
    ..Experiments will determine impact of infection on the antigen specific T cell response in NALT and other lymphoid organs. ..
  55. Fas-Mediated Neutrophil Function in Neonates
    JOYCE KOENIG; Fiscal Year: 2003
    ..The studies outlined in this proposal will further our understanding of neutrophil biology in the developing human, and are critical to the design of future mechanistic studies. ..
  56. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2003
    ....
  57. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..