Genomes and Genes
Summary: A bacterium which causes mastitis in cattle and occasionally in man.
Publications305 found, 100 shown here
- The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30David G Pritchard
Department of Biochemistry and Molecular Genetics, MCLM 552, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
Microbiology 150:2079-87. 2004..Site-directed mutagenesis of conserved cysteine and histidine residues in the CHAP domain and conserved aspartate and glutamate residues in the Acm domain confirmed their importance for lysozyme and endopeptidase activity respectively...
- Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acidKelly S Doran
Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
J Clin Invest 115:2499-507. 2005..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
- The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective studyDavide Lijoi
Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
Arch Gynecol Obstet 275:373-9. 2007..The aim of the current study is to evaluate the differences in the rate of perinatal group B streptococcal vertical transmission between women who correctly underwent the CDC 2002 guidelines and women who did not...
- Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010Jennifer R Verani
National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
MMWR Recomm Rep 59:1-36. 2010..In the absence of a licensed GBS vaccine, universal screening and intrapartum antibiotic prophylaxis continue to be the cornerstones of early-onset GBS disease prevention...
- Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysisKaren M Edmond
London School of Hygiene and Tropical Medicine, London, UK
Lancet 379:547-56. 2012..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates...
- The highly dynamic CRISPR1 system of Streptococcus agalactiae controls the diversity of its mobilomeMaría José López-Sánchez
Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, Paris, France
Mol Microbiol 85:1057-71. 2012..b>Streptococcus agalactiae, a leading cause of neonatal infections contains in its genome two CRISPR/Cas systems...
- Comparative genomics and the role of lateral gene transfer in the evolution of bovine adapted Streptococcus agalactiaeVincent P Richards
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Infect Genet Evol 11:1263-75. 2011In addition to causing severe invasive infections in humans, Streptococcus agalactiae, or group B Streptococcus (GBS), is also a major cause of bovine mastitis. Here we provide the first genome sequence for S...
- Characterization of Streptococcus agalactiae CAMP factor as a pore-forming toxinShenhui Lang
Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
J Biol Chem 278:38167-73. 2003A recombinant form of CAMP factor of Streptococcus agalactiae has been expressed as glutathione S-transferase-CAMP fusion protein in Escherichia coli...
- Group B streptococcus and early-onset sepsis in the era of maternal prophylaxisJoyce M Koenig
Department of Pediatrics, Division of Neonatal Perinatal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
Pediatr Clin North Am 56:689-708, Table of Contents. 2009..Modern technologies, such as those involving proteomics and genomic sequencing, are likely to hasten the development of a universal vaccine against GBS...
- Immune activation and suppression by group B streptococcus in a murine model of urinary tract infectionKimberly A Kline
Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Infect Immun 79:3588-95. 2011..These studies define several basic molecular and cellular events characterizing GBS UTI in an animal model, showing that GBS participates simultaneously in the activation and suppression of host immune responses in the urinary tract...
- Diversity of group B streptococcus serotypes causing urinary tract infection in adultsKimberly B Ulett
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Clin Microbiol 47:2055-60. 2009..Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS...
- Serotype IX, a Proposed New Streptococcus agalactiae SerotypeHans Christian Slotved
Neisseria and Streptococcus Reference Laboratory, Department for Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
J Clin Microbiol 45:2929-36. 2007We identified three isolates of Streptococcus agalactiae (group B streptococcus [GBS]), of human origin, which failed to react with antisera against any of the nine known GBS serotypes...
- Comparison of BD GeneOhm real-time polymerase chain reaction with chromogenic and conventional culture methods for detection of group B Streptococcus in clinical samplesDawn Smith
Microbiology Department, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
Diagn Microbiol Infect Dis 61:369-72. 2008..5% versus 57% respectively, P < 0.02). After selective enrichment, 92.8% of GBS were isolated on chromID Strepto B compared with 89.2% isolated on sheep blood agar...
- The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiaePhilipp Ellinger
Institute of Biochemistry, Heinrich Heine University, Universitatsstr 1, 40225 Dusseldorf, Germany
J Struct Biol 178:350-62. 2012..We could verify that Csn2 binds ds-DNA. In addition molecular dynamics simulations suggested a Csn2 conformation that can "sit" on the DNA helix and binds DNA in a groove on the outside of the ring...
- Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetrationAnirban Banerjee
Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, California 92182, USA
Nat Commun 2:462. 2011..Our results suggest that the bacterial pilus, specifically the PilA adhesin, has a dual role in immune activation and bacterial entry into the CNS...
- Sudden increase in isolation of group B streptococci, serotype V, is not due to emergence of a new pulsed-field gel electrophoresis typeJ A Elliott
Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
J Clin Microbiol 36:2115-6. 1998..We concluded that the majority of isolates of GBS-V are of one PFGE subtype and that this subtype was predominate before the increase in disease caused by GBS-V and that GBS-V disease is caused by several different subtypes...
- A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiaeMathieu Brochet
Unité de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Bacteriol 190:672-80. 2008..Through DNA array analysis, we have identified two Streptococcus agalactiae strains carrying tandem genome amplifications: a fourfold amplification of 13...
- A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80Krishnan Vengadesan
Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Mol Biol 407:731-43. 2011The Gram-positive pathogen Streptococcus agalactiae, known as group B Streptococcus (GBS), is the leading cause of bacterial septicemia, pneumonia, and meningitis among neonates...
- Group B Streptococcus: global incidence and vaccine developmentAtul Kumar Johri
School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
Nat Rev Microbiol 4:932-42. 2006..This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens...
- Contribution of Mn-cofactored superoxide dismutase (SodA) to the virulence of Streptococcus agalactiaeC Poyart
INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
Infect Immun 69:5098-106. 2001..To analyze the role of this enzyme in the pathogenicity of GBS, we constructed a sodA-disrupted mutant of Streptococcus agalactiae NEM316 by allelic exchange...
- The SrtA Sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestineLila Lalioui
Unité de Biologie des Bactéries Pathogènes à Gram Positif, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
Infect Immun 73:3342-50. 2005b>Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal pneumonia, sepsis, and meningitis...
- Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal diseaseScilla Buccato
Novartis Vaccines, 1 53100 Siena, Italy
J Infect Dis 194:331-40. 2006..These data pave the way to the design of pilus-based, multivalent live vaccines against streptococcal pathogens...
- Evaluation of universal antenatal screening for group B streptococcusMelissa K Van Dyke
Epidemic Intelligence Service Program, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 360:2626-36. 2009..In 2002, national guidelines recommended universal late antenatal screening of pregnant women for colonization with group B streptococcus to identify candidates for intrapartum chemoprophylaxis...
- Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007Tami H Skoff
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 49:85-92. 2009..We used population-based surveillance to examine trends in adult GBS disease during the period 1990-2007 and to describe the epidemiology of adult GBS disease to guide prevention efforts...
- The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonatesAsmaa Tazi
Institut Cochin, Université Paris Descartes Faculté de Médecine, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France
J Exp Med 207:2313-22. 2010b>Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis...
- Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteinsIzabela Sitkiewicz
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
BMC Microbiol 11:65. 2011..Ten RD2-encoded proteins have significant similarity to proteins involved in conjugative transfer of Streptococcus thermophilus integrative chromosomal elements (ICEs)...
- Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8Kelly S Doran
Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
J Infect Dis 185:196-203. 2002..These data indicate that the GBS beta-h/c contributes to invasion and immune activation of lung epithelial cells and may represent a multifunctional virulence factor in the early pulmonary stages of GBS infection...
- Invasive group B streptococcal infections in infants, FranceClaire Poyart
Institut National de la Sante et de la Recherche Medicale, U567, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 810, Paris, France
Emerg Infect Dis 14:1647-9. 2008..Sixty-four percent of the strains were from late-onset infections, and 75% were capsular type III. The hypervirulent clone ST-17 was recovered in 80% of meningitis cases...
- Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigmImmaculada Margarit
Novartis Vaccines, Siena, Italy
J Infect Dis 199:108-15. 2009..the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit ..
- Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005Christina R Phares
Epidemic Intelligence Service Program, Office of Workforce and Career Development, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
JAMA 299:2056-65. 2008..Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development...
- Multilocus sequence types associated with neonatal group B streptococcal sepsis and meningitis in CanadaShannon D Manning
Department ofPediatrics and Human Development, Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, E Lansing, Michigan 48824, USA
J Clin Microbiol 47:1143-8. 2009..Further research is required to better understand why strains belonging to the ST-17 phylogenetic lineage are more likely to cause both LOD and meningitis and may provide clues into the pathogenesis of these conditions...
- Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptidesAndrea Hamilton
Department of Pediatrics, University of Washington, and Children s Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, USA
Infect Immun 74:6179-87. 2006..While the peptidoglycan polymerization and cross-linking activity of PBPs are essential for bacterial survival, our study is the first to identify a role for a PBP in resistance to host AMPs...
- The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunityMagali Bebien
Centre d Immunologie de Marseille Luminy CIML, Aix Marseille University, UM2, Marseille, France
PLoS Pathog 8:e1002812. 2012..Our studies suggest p38 MAPK may represent a new therapeutic target to blunt virulence and improve clinical outcome of invasive GBS infection...
- Group B streptococcal disease in infants: progress in prevention and continued challengesJennifer R Verani
Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS C 23, Atlanta, GA 30333, USA
Clin Perinatol 37:375-92. 2010..This article discusses implementation challenges for clinicians caring for pregnant women and newborns and presents an updated algorithm for neonatal management...
- Sortase A substrate specificity in GBS pilus 2a cell wall anchoringFrancesca Necchi
Novartis Vaccines and Diagnostics, Siena, Italy
PLoS ONE 6:e25300. 2011b>Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS), is one of the most common causes of life-threatening bacterial infections in infants...
- NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNASachin D Deshmukh
Center of Chronic Immunodeficiency, University of Freiburg, 79106 Freiburg, Germany
J Immunol 188:774-80. 2012..This NO-dependent amplification loop has important mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesis...
- Neonatal sepsis workups in infants >/=2000 grams at birth: A population-based studyG J Escobar
Kaiser Permanente Medical Care Program, Division of Research, Perinatal Research Unit, Oakland, California 94611, USA
Pediatrics 106:256-63. 2000..Few data are available on the outcome of neonatal sepsis evaluations in an era when intrapartum antibiotic therapy is common...
- Group B streptococcus serotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distributionDanielle L Ippolito
Department of Clinical Investigation, Madigan Healthcare System, 9040 Reid St, Tacoma, WA 98431, USA
BMC Infect Dis 10:336. 2010....
- Two coregulated efflux transporters modulate intracellular heme and protoporphyrin IX availability in Streptococcus agalactiaeAnnabelle Fernandez
Institut National de la Recherche Agronomique, UMR1319 MICALIS, Bâtiment 222, Domaine de Vilvert, Jouy en Josas, France
PLoS Pathog 6:e1000860. 2010b>Streptococcus agalactiae is a major neonatal pathogen whose infectious route involves septicemia...
- The prevention of early-onset neonatal group B streptococcal diseaseDeborah M Money
J Obstet Gynaecol Can 26:826-40. 2004..To review the evidence in the literature and to provide recommendations on the management of pregnant women in labour for the prevention of early-onset neonatal group B streptococcal (GBS) disease...
- Molecular characterization of capsular polysaccharides and surface protein genes in relation to genetic similarity of group B streptococci isolated from Polish pregnant womenM Brzychczy-Włoch
Department of Bacteriology, Microbial Ecology and Parasitology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland
Epidemiol Infect 140:329-36. 2012..The distribution of serotypes and surface proteins of GBS strains are necessary data to inform the design and formulation of new GBS vaccines for use in Poland and other countries...
- Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococciJ L Michel
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA
Proc Natl Acad Sci U S A 89:10060-4. 1992..The large region of identical repeating units in bca defines protective epitopes and may play a role in generating phenotypic and genotypic diversity of the alpha antigen...
- IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammationToby Lawrence
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
Nature 434:1138-43. 2005..Inactivation of IKKalpha in mice enhances inflammation and bacterial clearance. Hence, the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity...
- Streptococcus agalactiae in adults at Chiang Mai University Hospital: a retrospective studyRomanee Chaiwarith
Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
BMC Infect Dis 11:149. 2011Infection caused by Streptococcus agalactiae, a Group B streptococcus, is an emerging disease in non-pregnant adults. This study describes the epidemiological, clinical, and microbiological characteristics of S...
- Detection of group B streptococci in Lim broth by use of group B streptococcus peptide nucleic acid fluorescent in situ hybridization and selective and nonselective agarsNaomi S Montague
Department of Pathology, Jackson Memorial Hospital, and the University of Miami Miller School of Medicine, Miami, Florida, USA
J Clin Microbiol 46:3470-2. 2008..4%, 100%, 100%, and 87.9%, respectively; for culture on SSA, 85.5%, 100%, 100%, and 94.1%, respectively; and for the PNA FISH assay, 97.4%, 98.3%, 96.1%, and 98.9%, respectively...
- Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal diseaseGiuseppe Mancuso
Department of Pathology and Experimental Microbiology, University of Messina Medical School, Messina, Italy
J Immunol 172:6324-9. 2004..In conclusion, these data highlight a dual role of TLR2 and MyD88 in the host defense against GBS sepsis and strongly suggest TNF-alpha as the molecular mediator of bacterial clearance and septic shock...
- Invasive group B streptococcal infection in infants, MalawiKatherine J Gray
Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi
Emerg Infect Dis 13:223-9. 2007..Effective locally relevant prevention strategies are needed...
- Identification of Streptococcus agalactiae isolates from various phylogenetic lineages by matrix-assisted laser desorption ionization-time of flight mass spectrometryMarie Frédérique Lartigue
Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno foetal, Tours, France
J Clin Microbiol 47:2284-7. 2009..Using this method, we identified 110 Streptococcus agalactiae isolates characterized by serotyping and multilocus sequence typing...
- [Invasive Streptococcus agalactiae infections in non-pregnant adults]N Lefebvre
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Strasbourg, 1, Place de l Hopital, 67091 Strasbourg Cedex, France
Med Mal Infect 37:796-801. 2007b>Streptococcus agalactiae (Group B streptococcus) is a major cause of invasive diseases in non-pregnant adults, particularly in the elderly and those with underlying conditions...
- Rga, a RofA-like regulator, is the major transcriptional activator of the PI-2a pilus in Streptococcus agalactiaeShaynoor Dramsi
Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, Paris, France
Microb Drug Resist 18:286-97. 2012..environments is key in determining the outcome of infections caused by the opportunistic human pathogen Streptococcus agalactiae. We previously demonstrated that the RofA-like protein (RALP) regulators RogB and Rga activate their ..
- Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in GermanyMirjam Kunze
Department of Obstetrics and Gynecology, University Hospital Freiburg, Freiburg, Germany
J Perinat Med 39:417-22. 2011..To evaluate colonization, transmission rate and serotype distribution of group B streptococci (GBS) in pregnant women and infants born in a single University Center in Germany...
- Comparison of carrot broth- and selective Todd-Hewitt broth-enhanced PCR protocols for real-time detection of Streptococcus agalactiae in prenatal vaginal/anorectal specimensTimothy Block
Wheaton Franciscan Laboratory, 11020 West Plank Court, Suite 100, Wauwatosa, WI 53226, USA
J Clin Microbiol 46:3615-20. 2008The reporting of accurate Streptococcus agalactiae screening results in a short time frame is of tremendous clinical benefit...
- [Polish Gynecological Society's recommendations regarding diagnosis and prevention of streptococcus agalactiae infection in pregnant women and newborns]Jan Kotarski
Katedra Mikrobiologii CM UJ w Krakowie
Ginekol Pol 79:221-3. 2008
- Late and ultra late onset Streptococcus B meningitis: clinical and bacteriological data over 6 years in FranceJ Guilbert
Department of Paediatric Intensive Care Unit, Trousseau s Hospital, Paris, France
Acta Paediatr 99:47-51. 2010....
- Comparison of rapid intrapartum screening methods for group B streptococcal vaginal colonizationNatali Aziz
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94025, USA
J Matern Fetal Neonatal Med 18:225-9. 2005..To compare optical immunoassay (OIA) and rapid polymerase-chain reaction (PCR) with enrichment broth culture for intrapartum detection of vaginal group B streptococcal (GBS) colonization...
- Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tractTamsin R Sheen
Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA
J Bacteriol 193:6834-42. 2011b>Streptococcus agalactiae (group B streptococcus [GBS]) is a Gram-positive bacterium found in the female rectovaginal tract and is capable of producing severe disease in susceptible hosts, including newborns and pregnant women...
- Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulenceMichel Yves Mistou
Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, Paris Cedex 15, France
J Bacteriol 191:4195-206. 2009..The secA2 locus of Streptococcus agalactiae strain NEM316 is structurally related to those found in other streptococci and encodes the serine-rich ..
- Neonatal group B streptococcal disease: from pathogenesis to preventive strategiesP Melin
National Reference Centre for Group B Streptococci, Medical Microbiology Department, University Hospital of Liege, Liege, Belgium
Clin Microbiol Infect 17:1294-303. 2011b>Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, as early-onset or late-onset diseases (EOD, LOD)...
- Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1alphaGlen C Ulett
Departments of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
J Infect Dis 201:866-70. 2010..Thus, binding of uropathogenic GBS to uroepithelium and vigorous induction of interleukin 1alpha represents the initial stages of GBS urinary tract infection...
- A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotypingEve Haguenoer
Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
BMC Microbiol 11:171. 2011Multilocus sequence typing (MLST) is currently the reference method for genotyping Streptococcus agalactiae strains, the leading cause of infectious disease in newborns and a major cause of disease in immunocompromised children and adults...
- Adherence to perinatal group B streptococcal prevention guidelinesWilliam P Goins
Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Obstet Gynecol 115:1217-24. 2010....
- Mechanisms of group B streptococcal-induced apoptosis of murine macrophagesGlen C Ulett
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 175:2555-62. 2005Apoptosis of murine and human macrophages induced by group B Streptococcus agalactiae (GBS) is likely an important virulence mechanism that is used by the bacteria to suppress the host immune response and to persist at sites of infection...
- Group B streptococcal disease in nonpregnant patients: emergence of highly resistant strains of serotype Ib in Taiwan in 2006 to 2008Ying Hsiang Wang
Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, Taiwan
J Clin Microbiol 48:2571-4. 2010..Serotype Ib isolates (24.6%) were the second most prevalent serotype, next to serotype V (29.4%), and showed the highest resistance rates to erythromycin (91.0%) and clindamycin (82.1%)...
- The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophagesNicola J Cumley
School of Biosciences, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Infect Immun 80:1650-61. 2012..Moreover, we show that the GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome...
- Group B Streptococcus surface proteins as major determinants for meningeal tropismAsmaa Tazi
Institut Cochin, Université Paris Descartes Sorbonne Paris Cité, CNRS UMR 8104, Paris, France
Curr Opin Microbiol 15:44-9. 2012b>Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with ..
- CAMP factor is not essential for systemic virulence of Group B StreptococcusMary E Hensler
Division of Pediatric Pharmacology and Drug Discovery, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
Microb Pathog 44:84-8. 2008..Our data suggest that CAMP factor expressed in its native context is not essential for systemic virulence of GBS...
- Focal adhesion kinase is involved in type III group B streptococcal invasion of human brain microvascular endothelial cellsSooan Shin
Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Park 256, Baltimore, MD 21287, USA
Microb Pathog 41:168-73. 2006..This is the first demonstration that FAK phosphorylation and its association with paxillin and PI3 kinase play a key role in type III GBS invasion of HBMEC...
- The prevalence of streptococcus agalactiae (group B) colonization in pregnant women at Thammasat HospitalSiripen Tor-Udom
Department of Microbiology, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12121, Thailand
J Med Assoc Thai 89:411-4. 2006..Group B Streptococci (GBS) is responsible for serious infections in newborns such as septicemia and meningitis...
- The cell lysis activity of the Streptococcus agalactiae bacteriophage B30 endolysin relies on the cysteine, histidine-dependent amidohydrolase/peptidase domainDavid M Donovan
Biotechnology and Germplasm Laboratory, ANRI, ARS, USDA, Bldg 230, Room 104, BARC East, 10300 Baltimore Ave, Beltsville, MD 20705 23501, USA
Appl Environ Microbiol 72:5108-12. 2006The Streptococcus agalactiae bacteriophage B30 endolysin contains three domains: cysteine, histidine-dependent amidohydrolase/peptidase (CHAP), Acm glycosidase, and the SH3b cell wall binding domain...
- Genome analysis reveals pili in Group B StreptococcusPeter Lauer
Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy
Science 309:105. 2005..Immunogold electron microscopy revealed that the structures have a pilus-like form. These large structures have gone unrecognized in decades of studies of Group B Streptococcus...
- Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ionMika K Rantanen
Institute of Biotechnology, University of Helsinki, Finland, and Division of Infectious Disease, Children s Hospital and Regional Medical Center, Seattle, WA, USA
FEBS J 274:3128-37. 2007We solved the crystal structure of Streptococcus agalactiae serine/threonine phosphatase (SaSTP) using a combination of single-wavelength anomalous dispersion phasing and molecular replacement...
- Functional analysis of a PcsB-deficient mutant of group B streptococcusDieter J Reinscheid
Department of Microbiology and Biotechnology, University of Ulm, D 89069 Ulm, Germany
FEMS Microbiol Lett 221:73-9. 2003..Northern blot analysis exhibited similar expression of the enolase gene in the GBS strains 6313 and Sep1, indicating that mutant Sep1 is impaired in the anchoring of this protein to its cell wall...
- Bioinformatic insights into the biosynthesis of the Group B carbohydrate in Streptococcus agalactiaeIain C Sutcliffe
Northumbria University, Newcastle upon Tyne NE1 8ST, UK
Microbiology 154:1354-63. 2008b>Streptococcus agalactiae is a major human and animal pathogen, most notable as a cause of life-threatening disease in neonates. S...
- Choriodecidual inflammation: a harbinger of the preterm labor syndromePeta L Grigsby
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
Reprod Sci 17:85-94. 2010....
- Specific involvement of pilus type 2a in biofilm formation in group B StreptococcusCira Daniela Rinaudo
Novartis Vaccines and Diagnostics, Siena, Italy
PLoS ONE 5:e9216. 2010b>Streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis...
- Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetrationAnnalisa Lembo
Department of Pediatric Infectious Diseases, University of Washington School of Medicine, Seattle, WA 98195, USA
Mol Microbiol 77:431-43. 2010....
- Molecular characterization and prophage DNA contents of Streptococcus agalactiae strains isolated from adult skin and osteoarticular infectionsMazen Salloum
Equipe d Accueil 3854, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, UFR Medecine, Universite Francois Rabelais de Tours, 37032 Tours Cedex, France
J Clin Microbiol 48:1261-9. 2010Skin and osteoarticular infections (SKI and OAI, respectively) account for almost one-third of Streptococcus agalactiae infections in nonpregnant adults. We evaluated the genetic diversity and phylogeny of 58 S...
- Enhanced expression of lmb gene encoding laminin-binding protein in Streptococcus agalactiae strains harboring IS1548 in scpB-lmb intergenic regionRim Al Safadi
Equipe d Accueil 3854 Bactéries et Risque Materno Foetal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, UFR Medecine, Universite Francois Rabelais de Tours, Tours, France
PLoS ONE 5:e10794. 2010....
- Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human lamininB Spellerberg
Institute of Medical Microbiology, University Hospital Aachen, D 52057 Aachen, Germany
Infect Immun 67:871-8. 1999b>Streptococcus agalactiae is a leading cause of neonatal sepsis and meningitis...
- Structural and genetic diversity of group B streptococcus capsular polysaccharidesMichael J Cieslewicz
Division of Infectious Diseases, Children s Hospital, University of Washington, Seattle, WA 98109, USA
Infect Immun 73:3096-103. 2005....
- Morbidity related to maternal group B streptococcal infectionsAnouk E Muller
Department of Obstetrics and Gynecology, Medical Centre Haaglanden, The Hague, The Netherlands
Acta Obstet Gynecol Scand 85:1027-37. 2006..We describe the various maternal group B streptococcal infections, their characteristics, associated neonatal morbidity, and prevention and treatment strategies during pregnancy, delivery, and in the postpartum period...
- Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory systemC Poyart
Laboratoire de Microbiologie, INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
J Bacteriol 183:6324-34. 2001..In this work, we characterized the dlt operon of Streptococcus agalactiae, which, in addition to the dltA to dltD genes, included two regulatory genes, designated dltR and dltS, ..
- CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine developmentIsabella Santi
Novartis Vaccines and Diagnostics Srl, Via Fiorentina 1, 53100 Siena, Italy
J Bacteriol 191:5387-97. 2009..0 induced opsonophagocytic killing of GBS in immune serum highlights the importance of pH regulation in the protective efficacy of specific antibodies to surface-exposed GBS proteins...
- The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defensesDarin Quach
Department of Biology and Center for Microbial Sciences, San Diego State University, CA 92182, USA
J Bacteriol 191:2023-32. 2009..Our results identify the GBS CiaR response regulator as a crucial factor in GBS intracellular survival and invasive disease pathogenesis...
- Assembly and role of pili in group B streptococciShaynoor Dramsi
Unité de Biologie des Bactéries Pathogènes à Gram Positif Institut Pasteur, URA CNRS 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 60:1401-13. 2006b>Streptococcus agalactiae[group B streptococcus (GBS)] is the leading cause of neonatal pneumonia, sepsis and meningitis...
- Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory proteinPedro Madureira
ICBAS Instituto de Ciências Biomédicas de Abel Salazar, Porto, Portugal
J Immunol 178:1379-87. 2007..In this study, a protein with B lymphocyte stimulatory activity was isolated from culture supernatants of Streptococcus agalactiae strain NEM316...
- Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999John F Bohnsack
University of Utah Health Sciences Center, Department of Pediatrics, 50 North Medical Dr, Salt Lake City, UT 84132, USA
J Clin Microbiol 46:1285-91. 2008..7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates...
- Horizontal gene transfer and host specificity of beta-haemolytic streptococci: the role of a putative composite transposon containing scpB and lmbC Franken
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, Pauwelsstr 30, 52057 Aachen, Germany
Mol Microbiol 41:925-35. 2001..The surface protein, Lmb, mediates the adherence of Streptococcus agalactiae to human laminin...
- The transcriptional regulator RovS controls the attachment of Streptococcus agalactiae to human epithelial cells and the expression of virulence genesUlrike M Samen
Department of Microbiology and Biotechnology, University of Ulm, Albert Einstein Allee 11, D 89069 Ulm, Germany
Infect Immun 74:5625-35. 2006b>Streptococcus agalactiae is part of the normal flora of the human gastrointestinal tract and also the leading cause of bacterial infections in human newborns and immunocompromised adults...
- A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sitesAxel Schubert
Department of Microbiology and Biotechnology, University of Ulm, Germany
Mol Microbiol 46:557-69. 2002....
- Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase: surface localization, enzymatic activity, and protein-protein interactionsKyle N Seifert
Department of Oral Biology, College of Dentistry, University of Florida, Gainsville, FL 32610 0424, USA
Can J Microbiol 49:350-6. 2003..Enzymatically active GAPDH, capable of binding cytoskeletal and extracellular matrix proteins, is expressed on the surface of GBS...
- Multilocus sequence typing system for group B streptococcusNicola Jones
Nuffield Department of Clinical Laboratory Sciences, Institute for Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Clin Microbiol 41:2530-6. 2003..A web site for GBS MLST was set up and can be accessed at http://sagalactiae.mlst.net. The GBS MLST system offers investigators a valuable typing tool that will promote further investigation of the population biology of this organism...
- The Delta subunit of RNA polymerase is required for virulence of Streptococcus agalactiaeAmanda L Jones
Department of Pediatrics, Division of Infectious Diseases, Children s Hospital and Regional Medical Center and University of Washington, Seattle, Washington 98105, USA
Infect Immun 71:4011-7. 2003..Our data represent the first report of a phenotype relevant to virulence for rpoE mutants...
- Comparative evaluation of Strepto B ID chromogenic medium and Granada media for the detection of Group B streptococcus from vaginal samples of pregnant womenAsmaa Tazi
Service de Bacteriologie, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Centre National de Référence des Streptocoques, Paris, France
J Microbiol Methods 73:263-5. 2008..All tested media were comparable in terms of sensitivity however, their use in routine laboratories may markedly facilitate the rapid detection of GBS in vaginal samples...
- Epidemiology of and prenatal molecular distinction between invasive and colonizing group B streptococci in The Netherlands and TaiwanE van Elzakker
Department of Microbiology, Haga Hospital, PO Box 40551, 2504 LN, The Hague, The Netherlands
Eur J Clin Microbiol Infect Dis 28:921-8. 2009..826-0.963). PPI-specific and serological markers can distinguish local neonatal invasive GBS strains from colonizing ones. Apparently, there are clear regional differences in the GBS epidemiology and infection potential of clones...
- Understanding the regulation of Group B Streptococcal virulence factorsLakshmi Rajagopal
Department of Pediatric Infectious Diseases, University of Washington and Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101 91304, USA
Future Microbiol 4:201-21. 2009..Consequently, understanding signaling responses of GBS is essential for elucidation of pathogenesis of GBS infection and for the identification of novel therapeutic agents...
- Latex assay for serotyping of group B Streptococcus isolatesH C Slotved
Production Unit, Department of Respiratory Infections, Meningitis and STIs, Division of Microbiology, Statens Serum Institut, Copenhagen, Denmark
J Clin Microbiol 41:4445-7. 2003..A total of 232 isolates were tested, and 203 isolates were serotyped by the GBS latex test, while the capillary precipitation test serotyped 184 isolates...
- Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiaeYoan Konto-Ghiorghi
Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif and URA CNRS 2172, Paris, France
PLoS Pathog 5:e1000422. 2009b>Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process...
- Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cellsAlfredo Pezzicoli
Novartis Vaccines and Diagnostics, Siena, Italy
J Infect Dis 198:890-8. 2008..These findings suggest a dual role for pilus components during the critical steps leading to GBS dissemination in the host...
- Streptococcus agalactiae invasion of human brain microvascular endothelial cells is promoted by the laminin-binding protein LmbTobias Tenenbaum
Pädiatrische Infektiologie, Klinik fur Allgemeine Padiatrie, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Microbes Infect 9:714-20. 2007b>Streptococcus agalactiae (S. agalactiae) can cause severe pneumonia, sepsis and meningitis in neonates and remains one of the most prevalent causes of invasive neonatal infections. During the course of infection, S...
- Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5Aaron F Carlin
Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 206:1691-9. 2009..We conclude that protein-mediated functional engagement of an inhibitory host lectin receptor promotes bacterial innate immune evasion...
- Analysis of Group B Streptococcal Fibrinogen CleavageDaniel Shelver; Fiscal Year: 2005..The availability of the purified protein will facilitate future biochemical structure-function studies on this important virulence factor of GBS. ..
- GROUP B STREPTOCOCCAL SURFACE PROTEINS IN IMMUNE EVASIONLAWRENCE MADOFF; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Project Summary: This project on group B Streptococcus (Streptococcus agalactiae) focuses on a class of key surface proteins called alpha-like proteins that are also found on a variety of ..
- The Abeta protein of Alzheimer's Disease is an antimicrobial peptideRobert D Moir; Fiscal Year: 2013..Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae. A[unreadable] is a more potent antimicrobial agent than LL-37 for at least two of these microorganisms...
- MtaR-regulated virulence in Streptococcus agalactiaeDaniel Shelver; Fiscal Year: 2009DESCRIPTION (provided by applicant). Streptococcus agalactiae (group B Streptococcus;GBS) is a leading cause of invasive infections such as pneumonia, sepsis, and meningitis in neonates...
- MOLECULAR MECHANISMS OF FIBRINOLYSISPaul E Bock; Fiscal Year: 2013..cofactor of tPA-catalyzed Pg activation, and to evaluate its potential role as pathogenicity factor in Streptococcus agalactiae infections...
- Pilus Assembly in Gram-Positive BacteriaHung Ton That; Fiscal Year: 2010..We will determine, by biochemical and microscopic methods, whether Streptococcus agalactiae employes the same mechanism for pilus assembly...
- COMPARATIVE ANALYSIS OF GROUP A AND B STREPTOCCAL GENOMEJOSEPH FERRETTI; Fiscal Year: 2000..initiated a project to establish a physical and genetic map of the group B streptococcal genome (GBS, Streptococcus agalactiae)...
- Quorum Sensing in Group B StreptococcusMICHAEL CIESLEWICZ; Fiscal Year: 2006Group B Streptococcus (Streptococcus agalactiae or GBS) is the leading cause of gram positive neonatal meningitis and is an increasingly important cause of serious infection in elderly and chronically ill adults...
- Group B Streptococcal Surface Proteins Immune EvasionLAWRENCE MADOFF; Fiscal Year: 2005Group B Streptococcus (Streptococcus agalactiae) remains a major cause of death and serious illness in newborn babies and has emerged as an important pathogen in immunocompromised adults...
- NATURAL ANTIBODY AGAINST GROUP B STREPTOCCOUS IN MICEPeter Butko; Fiscal Year: 2001DESCRIPTION (Verbatim from Applicant's Abstract): Group B streptococcus (GBS, Streptococcus agalactiae) is the most common cause of neonatal sepsis and meningitis in the USA...
- NEW POTENTIAL VIRULENCE FACTOR IN E FAECALISNathan Shankar; Fiscal Year: 2001..Employing this approach, a highly conserved homolog of Streptococcus agalactiae C alpha protein antigen has been identified in a clinical isolate of E. faecalis. The C proteins of S...
- Multiplex Prenatal Screen for Perinatal PathogensHeather Kiefer; Fiscal Year: 2004..acid-based multiplex test for the detection and quantification of the most common perinatal pathogens; Streptococcus agalactiae (group B streptococcus), Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex virus 1 and 2...
- Development of a Global GBS VaccineLAWRENCE PAOLETTI; Fiscal Year: 2007..This work will lead to a vaccine effective in preventing GBS diseases worldwide. ..
- Bacterial Vaccine Antigen DiscoveryLAWRENCE PAOLETTI; Fiscal Year: 2006..Aim 2). Findings from these studies utilizing this unique approach to vaccine antigen discovery could be directly applied to other bacterial pathogens. ..
- Mechanisms of Tandem Repeat Deletion in Group B StrepKAREN PUOPOLO; Fiscal Year: 2006..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
- GENETIC ANALYSIS OF GBS ADHERENCE TO FIBRONECTINGLEN TAMURA; Fiscal Year: 2002..These studies will allow for identification of the structural gene(s) for fibronectin adhesin(s). ..
- MATERNAL IMMUNIZATION TO PREVENT INFANT OTITIS MEDIAPatricia Ferrieri; Fiscal Year: 2005..Results of this trial will have a profound impact on the broad field of maternal immunization to prevent early infant disease caused by a variety of infant bacterial and viral pathogens. ..
- GBS: Epidemiologic Characterization for Gene DiscoveryBetsy Foxman; Fiscal Year: 2007..A better understanding of the molecular epidemiology and the identification of new GBS virulence genes will facilitate the discover of new therapies and prevention strategies for GBS disease. ..
- VIRULENCE FACTORS OF GROUP B STREPTOCOCCIJohn Bohnsack; Fiscal Year: 2001..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..
- Oral and Vaginal Microbes, Human Genotype, and Preterm BirthDawn P Misra; Fiscal Year: 2010..For this proposal we have the great advantage of exploring these hypotheses using already collected specimens and data as part of completed studies of preterm birth. ..
- Group B Strep Alp Protein-Epithelial Cell InteractionMIRIAM BARON BARSHAK; Fiscal Year: 2008..unreadable] [unreadable]..
- Lateral flow assay for detecting colonization by Streptococcus agalactiaeYing Li; Fiscal Year: 2008unreadable] DESCRIPTION (provided by applicant): Streptococcus agalactiae, a.k.a. group B streptococcus (GBS), is one of the leading causes of morbidity, and mortality among newborns...
- Inhibition of GBS Carriage by Engineered LactobacilliDavid Pritchard; Fiscal Year: 2004..If successful, this approach might also be used to protect against other genital, oral, and intestinal pathogens, especially those to which no effective mucosal immunity appears to develop. ..
- B. anthracis Peptidoglycan Deacetylase as a Drug TargetDavid Pritchard; Fiscal Year: 2005..anthracis, by inhibiting the deacetylases which specifically render their cell wall peptidoglycans resistant to the action of lysozyme. ..
- Role of penicillin binding protein 1a in GBS virulenceAmanda Jones; Fiscal Year: 2006..abstract_text> ..
- Characterization of iron transport in GBSKATHRYN CLANCY; Fiscal Year: 2004..The potential of identifying novel therapeutic targets to prevent or treat infections is also proposed. ..
- Genetic Diversity and Molecular Epidemiology of GBSHERBERT DAVIES; Fiscal Year: 2008..In addition, the assessment of colonizing GBS strains will provide fundamental insights into the nature of GBS colonization, which is the critical first step preceding neonatal transmission, infection and disease. ..
- INTRACELLULAR INFECTION BY INVASIVE GROUP A STREPTOCOCCIPaul Cleary; Fiscal Year: 2006..Information gained from this study may identify new targets for antibiotic development, and increase our understanding of the mechanisms by which this pathogen persists in human populations. ..
- Structural determinants of human immunity to anthraxDonald Reason; Fiscal Year: 2008..anthracis infection. In addition, the antibodies isolated will constitute a panel of fully human monoclonal binding domains with potential for therapeutic use as passive immunogens. [unreadable] [unreadable] [unreadable]..
- GENETICS OF VIRULENCE OF TYPE III GROUP B STREPTOCOCCUSCraig Rubens; Fiscal Year: 2003..They may also provide clues to the evolution of new GBS serotypes which are now causing human infections. ..
- Microfluidic system for point of care diagnosis of GBSMichel Bergeron; Fiscal Year: 2008..Moreover, this technology could also be applicable to the detection of other infectious disease agents including biological warfare agents. ..
- Srv is critical for Streptococcal survival in the hostSEAN REID; Fiscal Year: 2009..Understanding the mechanism of Srv-dependent gene regulation will provide new insights into the control of GAS disease. ..
- Role of Bacterial Vaginosis in Preterm DeliveryROBIN ROSS; Fiscal Year: 2003..Bacterial factors produced during coculture will be determined and correlated with stimulation of an inflammatory response. Due to the novelty of the models, we have the unique opportunity to determine the role of BVAF in PTD. ..
- Molecular epidemiologic identification of pneumococcal tissue specific genesMELINDA MARY PETTIGREW; Fiscal Year: 2010..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
- STREPTOCOCCAL INACTIVATOR IN HUMAN CHEMOATTRACTANTSPaul Cleary; Fiscal Year: 2006..New data indicates that the C5a peptide required for successful colonization and persistence of streptococci in nasal associated lymphoid tissue. ..
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
- Neutrophil Apoptosis and Neonatal InflammationJOYCE KOENIG; Fiscal Year: 2009..Thus, defining the biology of neutrophil apoptosis in the developing human is critical to future treatment modalities for CLD and other types of neonatal inflammation. ..
- OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATESCYNTHIA LOUISE BETHEA; Fiscal Year: 2010..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
- A RANDOMIZED CONTROLLED TRIAL OF ECHINACEA IN CHILDRENJames Taylor; Fiscal Year: 2001..abstract_text> ..
- MOLECULAR MECHANISMS OF THE HUMORAL IMMUNE RESPONSECLIFFORD SNAPPER; Fiscal Year: 2001..These studies will elucidate key parameters that underlie the molecular basis of Ig switching. ..
- Genetics of Autontibody DiversificationUmesh Deshmukh; Fiscal Year: 2008..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
- DENDRITIC AND T CELLS IN ANTI-BACTERIAL lg RESPONSESClifford M Snapper; Fiscal Year: 2010..abstract_text> ..
- Human monoclonal panel mimicking anthrax immune globulinDonald Reason; Fiscal Year: 2005..The PA-specific panel we construct will be molecularly defined and characterized, incorporate the advantages of toxin-specific, polyclonal human sera, and lack the inherent risk associated with blood derived products. ..
- Cardiac Depression in Gram-Positive Sepsis--Role of TLR2Jesus Vallejo; Fiscal Year: 2005..These studies will provide definitive new information with respect to the mechanisms responsible for the deleterious effects of gram-positive sepsis on cardiac function and structure. ..
- Gene Discovery for Pneumococcal Otitis MediaMelinda Pettigrew; Fiscal Year: 2005..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
- The Feasibility of Assessing the Prevalence of RicketsJames Taylor; Fiscal Year: 2006..In addition to assessing possible methodologies for the larger project, the preliminary study is designed to yield standalone results with important implications. [unreadable] [unreadable] [unreadable]..
- In Utero Infection: Child Health and NeurodevelopmentWilliam Andrews; Fiscal Year: 2005..abstract_text> ..
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- B7 COSTIMULATION RESPONSE TO EXTRACELLULAR BACTERIACLIFFORD SNAPPER; Fiscal Year: 2004..These experiments will provide insight into the mechanism of why B7-1 vs. B7-2 blockade differentially influences the R36A response. ..
- Role of a novel signal transduction pathway in GBSCraig Rubens; Fiscal Year: 2007The gram-positive pathogen Streptococcus agalactiae (group B streptococci, GBS) is the principal cause of human neonatal pneumonia, sepsis and meningitis. GBS is also an emerging pathogen of immunocompromised adults...
- Rhesus Embryonic Stem Cell-Derived Serotonin NeuronsCYNTHIA BETHEA; Fiscal Year: 2007..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
- MOLECULAR DETERMINANTS OF HUMAN PNEUMOCOCCAL IMMUNITYDonald Reason; Fiscal Year: 2004..Understanding the molecular mechanisms that shape the human antibody repertoire to pneumococcal polysaccharides may also suggest strategies that would facilitate the development of more efficacious vaccines. ..
- Genome Analysis of Streptococcus agalactiaeHerve Tettelin; Fiscal Year: 2002Group B streptococci (GBS) or Streptococcus agalactiae are weakly beta-hemolytic, facultatively anaerobic Gram-positive cocci, which have emerged over the past 50 years as the most significant bacterial cause of neonatal sepsis, pneumonia,..
- T cell immune response to group A streptococci in NALTPaul Cleary; Fiscal Year: 2008..Experiments will determine impact of infection on the antigen specific T cell response in NALT and other lymphoid organs. ..
- Fas-Mediated Neutrophil Function in NeonatesJOYCE KOENIG; Fiscal Year: 2003..The studies outlined in this proposal will further our understanding of neutrophil biology in the developing human, and are critical to the design of future mechanistic studies. ..
- DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUESJEANNE JORDAN; Fiscal Year: 2003....
- Toll-Like Receptors in Bacterial Antigen Induced HIV-LTROzlem Equils; Fiscal Year: 2004..abstract_text> ..