enterococcus faecalis

Summary

Summary: A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.

Top Publications

  1. ncbi Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis
    Nathan Shankar
    of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
    Nature 417:746-50. 2002
  2. ncbi Microbiology. The thin line between gut commensal and pathogen
    Michael S Gilmore
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Science 299:1999-2002. 2003
  3. ncbi Enterococcus faecalis: its role in root canal treatment failure and current concepts in retreatment
    Charles H Stuart
    Department of Endodontics, Wilford Medical Center, Lackland Air Force Base, Texas, USA
    J Endod 32:93-8. 2006
  4. pmc Genetic basis for daptomycin resistance in enterococci
    Kelli L Palmer
    Departments of Ophthalmology and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 55:3345-56. 2011
  5. ncbi Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium
    K Hegstad
    Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway
    Clin Microbiol Infect 16:541-54. 2010
  6. pmc Horizontal gene transfer and the genomics of enterococcal antibiotic resistance
    Kelli L Palmer
    Departments of Ophthalmology, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA
    Curr Opin Microbiol 13:632-9. 2010
  7. pmc Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Genome Biol 9:R110. 2008
  8. ncbi Effectiveness of selected materials against Enterococcus faecalis: part 3. The antibacterial effect of calcium hydroxide and chlorhexidine on Enterococcus faecalis
    Yu Heng Lin
    Department of Endodontics, Case Western Reserve University, School of Dentistry, Cleveland, OH 44106 4905, USA
    J Endod 29:565-6. 2003
  9. ncbi Eradication of Enterococcus faecalis biofilms by cetrimide and chlorhexidine
    María Teresa Arias-Moliz
    Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:87-90. 2010
  10. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002

Detail Information

Publications304 found, 100 shown here

  1. ncbi Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis
    Nathan Shankar
    of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
    Nature 417:746-50. 2002
    ..We examined the genomes of a strain of Enterococcus faecalis that caused an infectious outbreak in a hospital ward in the mid-1980s (ref...
  2. ncbi Microbiology. The thin line between gut commensal and pathogen
    Michael S Gilmore
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Science 299:1999-2002. 2003
  3. ncbi Enterococcus faecalis: its role in root canal treatment failure and current concepts in retreatment
    Charles H Stuart
    Department of Endodontics, Wilford Medical Center, Lackland Air Force Base, Texas, USA
    J Endod 32:93-8. 2006
    b>Enterococcus faecalis is a microorganism commonly detected in asymptomatic, persistent endodontic infections. Its prevalence in such infections ranges from 24% to 77%...
  4. pmc Genetic basis for daptomycin resistance in enterococci
    Kelli L Palmer
    Departments of Ophthalmology and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 55:3345-56. 2011
    ..Since its introduction, resistance to daptomycin by strains of Enterococcus faecalis and Enterococcus faecium has been reported but is still rare...
  5. ncbi Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium
    K Hegstad
    Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway
    Clin Microbiol Infect 16:541-54. 2010
    ..plasmids and transposons are pivotal in the dissemination and persistence of antimicrobial resistance in Enterococcus faecalis and Enterococcus faecium...
  6. pmc Horizontal gene transfer and the genomics of enterococcal antibiotic resistance
    Kelli L Palmer
    Departments of Ophthalmology, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA
    Curr Opin Microbiol 13:632-9. 2010
    ..Pheromone-responsive plasmids were recently shown to promote genome plasticity in antibiotic resistant Enterococcus faecalis, and their involvement has been implicated in E. faecium as well...
  7. pmc Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Genome Biol 9:R110. 2008
    b>Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies.
  8. ncbi Effectiveness of selected materials against Enterococcus faecalis: part 3. The antibacterial effect of calcium hydroxide and chlorhexidine on Enterococcus faecalis
    Yu Heng Lin
    Department of Endodontics, Case Western Reserve University, School of Dentistry, Cleveland, OH 44106 4905, USA
    J Endod 29:565-6. 2003
    It has been found that Enterococcus faecalis is most commonly isolated in failed endodontic treatment. Irrigation with chlorhexidine gluconate has been suggested based on its antimicrobial effect and substantivity...
  9. ncbi Eradication of Enterococcus faecalis biofilms by cetrimide and chlorhexidine
    María Teresa Arias-Moliz
    Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:87-90. 2010
    b>Enterococcus faecalis is the most commonly isolated bacteria from root canals of teeth with persistent periapical periodontitis. Its ability to grow as a biofilm impedes the elimination of E. faecalis by using irrigating solutions...
  10. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002
    The antibacterial activity of chlorhexidine digluconate and iodine potassium iodide on Enterococcus faecalis A197A was tested in the presence of dentin, dentin matrix, dentin pretreated by EDTA and citric acid, collagen, and heat-killed ..
  11. pmc Enterococcus faecalis rnjB is required for pilin gene expression and biofilm formation
    Peng Gao
    Center for Immunology and Autoimmune Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Bacteriol 192:5489-98. 2010
    ..Utilizing a monoclonal antibody developed against the Enterococcus faecalis major pilus protein EbpC, we identified mutants from a transposon (Tn) insertion library which lack ..
  12. pmc A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis
    Vinai Chittezham Thomas
    Division of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS, USA
    Mol Microbiol 72:1022-36. 2009
    ..DNA (eDNA), a by-product of cell lysis, was recently established as a critical structural component of the Enterococcus faecalis biofilm matrix...
  13. ncbi Association of Enterococcus faecalis with different forms of periradicular diseases
    Isabela N Rôças
    Institute of Microbiology Prof Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Endod 30:315-20. 2004
    Data from culture studies have revealed that Enterococcus faecalis is occasionally isolated from primary endodontic infections but frequently recovered from treatment failures...
  14. ncbi The role of environmental changes on monospecies biofilm formation on root canal wall by Enterococcus faecalis
    S George
    Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Singapore
    J Endod 31:867-72. 2005
    ..Although previous studies have established the ability of Enterococcus faecalis to survive postendodontic environmental conditions, the effect of such conditions on the ultrastructural ..
  15. pmc Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans
    Violeta Chavez
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 176:1567-77. 2007
    ..that the oxidative stress response genes sod-3 and ctl-2 are required for DAF-16-mediated resistance to Enterococcus faecalis using a C. elegans killing assay. We propose a model whereby C...
  16. ncbi Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro
    B P F A Gomes
    Endodontic Department, Piracicaba Dental School, State University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Int Endod J 36:267-75. 2003
    To evaluate the effectiveness of 2% chlorhexidine gluconate gel and calcium hydroxide (Ca(OH)2) as intracanal medicaments against Enterococcus faecalis.
  17. pmc Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits
    Janet M Manson
    Department of Ophthalmology and Microbiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:12269-74. 2010
    The Enterococcus faecalis pathogenicity island (PAI) encodes known virulence traits and >100 additional genes with unknown roles in enterococcal biology...
  18. pmc Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future
    M M Huycke
    University of Oklahoma Health Sciences Center 73190, USA
    Emerg Infect Dis 4:239-49. 1998
    ..Most enterococcal infections are caused by Enterococcus faecalis, which are more likely to express traits related to overt virulence but--for the moment--also more likely ..
  19. pmc Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals
    Diana Panesso
    Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia
    J Clin Microbiol 48:1562-9. 2010
    ..The overwhelming presence of plasmids encoding putative virulence factors and vanA genes suggests that E. faecium from the CC17 genogroup may disseminate in the region in the coming years...
  20. ncbi Mechanisms involved in the resistance of Enterococcus faecalis to calcium hydroxide
    M Evans
    School of Dental Science, University of Melbourne, Australia
    Int Endod J 35:221-8. 2002
    ..This study sought to clarify the mechanisms that enable E. faecalis to survive the high pH of calcium hydroxide...
  21. ncbi Antimicrobial efficacy of a polymeric chlorhexidine release device using in vitro model of Enterococcus faecalis dentinal tubule infection
    Yoon Lee
    Department of Conservative Dentistry, Wonkwang University Dental Hospital, Daejeon, Korea
    J Endod 34:855-8. 2008
    ..One hundred cylindrical dentin blocks prepared from human single-rooted teeth were inoculated with Enterococcus faecalis for 3 weeks...
  22. pmc Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL
    David A Boyd
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Antimicrob Agents Chemother 52:2667-72. 2008
    b>Enterococcus faecalis N06-0364, exhibiting a vancomycin MIC of 8 microg/ml, was found to harbor a novel D-Ala-D-Ser gene cluster, designated vanL...
  23. ncbi Genome-based insights into the evolution of enterococci
    W van Schaik
    Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Clin Microbiol Infect 16:527-32. 2010
    ..In this review, we discuss recent progress on the genomics of Enterococcus faecalis and Enterococcus faecium, which are the two enterococcal species that cause the large majority of ..
  24. ncbi Antimicrobial efficacy of chlorhexidine and two calcium hydroxide formulations against Enterococcus faecalis
    Edgar Schafer
    Poliklinik für Zahnerhaltung, University School of Dentistry, Munster, Germany
    J Endod 31:53-6. 2005
    ..this study was to investigate the efficacy of chlorhexidine (CHX) and calcium hydroxide (Ca(OH2) against Enterococcus faecalis in vitro. Extracted single-rooted human teeth were instrumented up to size 40...
  25. pmc Relative contributions of Ebp Pili and the collagen adhesin ace to host extracellular matrix protein adherence and experimental urinary tract infection by Enterococcus faecalis OG1RF
    Sreedhar R Nallapareddy
    Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 79:2901-10. 2011
    Previous studies have demonstrated that the ebp operon and the ace gene of Enterococcus faecalis, encoding endocarditis- and biofilm-associated pili and an adhesin to collagen of E...
  26. ncbi Pathogenesis and immunity in enterococcal infections
    I G Sava
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Clin Microbiol Infect 16:533-40. 2010
    b>Enterococcus faecalis and Enterococcus faecium have emerged as multi-resistant nosocomial pathogens in immunocompromised and critically ill patients...
  27. ncbi Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme
    Gustav Vaaje-Kolstad
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, N 1432 As, Norway
    J Mol Biol 416:239-54. 2012
    Little information exists for the ability of enterococci to utilize chitin as a carbon source. We show that Enterococcus faecalis V583 can grow on chitin, and we describe two proteins, a family 18 chitinase (ef0361; EfChi18A) and a ..
  28. pmc The Fsr quorum-sensing system of Enterococcus faecalis modulates surface display of the collagen-binding MSCRAMM Ace through regulation of gelE
    Kenneth L Pinkston
    Center for Immunology and Autoimmune Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Bacteriol 193:4317-25. 2011
    ..faecalis surface. These results demonstrate that the display of Ace is mediated by quorum sensing through the action of GelE, providing insight into the complicated world of Gram-positive pathogen adhesion and colonization...
  29. ncbi Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Linda M Weigel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 302:1569-71. 2003
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis.
  30. ncbi Horizontal transfer of virulence genes encoded on the Enterococcus faecalis pathogenicity island
    Phillip S Coburn
    Department of Pharmaceutical Sciences, The University of Oklahoma Health Sciences, Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Mol Microbiol 63:530-44. 2007
    b>Enterococcus faecalis, a leading cause of nosocomial antibiotic resistant infections, frequently possesses a 150 kb pathogenicity island (PAI) that carries virulence determinants...
  31. pmc Characterization of a vancomycin-resistant Enterococcus faecalis (VREF) isolate from a dog with mastitis: further evidence of a clonal lineage of VREF in New Zealand
    Janet M Manson
    Department of Microbiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Clin Microbiol 41:3331-3. 2003
    We report here on the characterization of a vancomycin-resistant Enterococcus faecalis (VREF) isolated from a dog with mastitis...
  32. pmc Comparative genomic analysis of pathogenic and probiotic Enterococcus faecalis isolates, and their transcriptional responses to growth in human urine
    Heidi C Vebø
    Laboratory of Microbial Gene Technology and Food Microbiology, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
    PLoS ONE 5:e12489. 2010
    Urinary tract infection (UTI) is the most common infection caused by enterococci, and Enterococcus faecalis accounts for the majority of enterococcal infections...
  33. ncbi Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium
    J Top
    Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Microbiol Infect 13:316-9. 2007
    ..This ecological change mimics events preceding the emergence of vancomycin-resistant E. faecium (VREF) in the USA and may presage the emergence of CC17 VREF in European hospitals...
  34. ncbi Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    I T Paulsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 299:2071-4. 2003
    The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA...
  35. ncbi Enterococcus faecalis biofilms eradication by root canal irrigants
    María Teresa Arias-Moliz
    Department of Microbiology, School of Dentistry, University of Granada, Granada, Spain
    J Endod 35:711-4. 2009
    ..CHX), EDTA, and citric and phosphoric acids after 1, 5, and 10 minutes of exposure to biofilms of Enterococcus faecalis. The biofilms grew in the MBEC high-throughput device for 24 hours at 37 degrees C and were exposed to 10 ..
  36. pmc Genetic diversity among Enterococcus faecalis
    Shonna M McBride
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e582. 2007
    b>Enterococcus faecalis, a ubiquitous member of mammalian gastrointestinal flora, is a leading cause of nosocomial infections and a growing public health concern...
  37. pmc Regulation of autolysis-dependent extracellular DNA release by Enterococcus faecalis extracellular proteases influences biofilm development
    Vinai Chittezham Thomas
    Division of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506, USA
    J Bacteriol 190:5690-8. 2008
    ..The Enterococcus faecalis Fsr quorum system has been shown to regulate biofilm formation through the production of gelatinase, but ..
  38. pmc Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis
    Christopher R Cox
    The Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Infect Immun 75:1565-76. 2007
    ..Among these organisms were several species of enterococci, including Enterococcus faecalis, Enterococcus faecium, Enterococcus gallinaraum, and Enterococcus durans, as well as a previously detected ..
  39. ncbi In vitro assessment of the effectiveness of chlorhexidine gel and calcium hydroxide paste with chlorhexidine against Enterococcus faecalis and Candida albicans
    Ertugrul Ercan
    Department of Operative Dentistry, School of Dentistry, University of Kirikkale, Kirikkale, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e27-31. 2006
    The purpose of this study was to compare the effectiveness of various medicaments, including Ca(OH)2/2% chlorhexidine, 2% chlorhexidine gel, and Ca(OH)2 alone, against Enterococcus faecalis and Candid albicans in vitro.
  40. ncbi Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments against Enterococcus faecalis in vitro
    Bettina Basrani
    Dalhousie University, Endodonic Division, Department of Dental Clinical Sciences, Halifax, Nova Scotia, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:618-24. 2003
    We sought to assess the efficacy of chlorhexidine (CHX) and calcium hydroxide, Ca(OH)(2), against Enterococcus faecalis in vitro.
  41. pmc Comparative genomics and transduction potential of Enterococcus faecalis temperate bacteriophages
    Azra Yasmin
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    J Bacteriol 192:1122-30. 2010
    ..of temperate bacteriophage in the horizontal gene transfer of fitness and virulence determinants of Enterococcus faecalis, a panel of 47 bacteremia isolates were treated with the inducing agents mitomycin C, norfloxacin, and UV ..
  42. pmc Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease
    Agathe Bourgogne
    Division of Infectious Disease, Center for the Study of Emerging and Re Emerging Pathogens, MSB 2 112, University of Texas Medical School, 6431 Fannin St, Houston, TX 77030, USA
    J Bacteriol 188:2875-84. 2006
    The FsrABC system of Enterococcus faecalis controls the expression of gelatinase and a serine protease via a quorum-sensing mechanism, and recent studies suggest that the Fsr system may also regulate other genes important for virulence...
  43. ncbi Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark
    F M Aarestrup
    Danish Veterinary Laboratory, 27 Bülowsvej, DK 1790 V, Copenhagen, Denmark
    Diagn Microbiol Infect Dis 37:127-37. 2000
    b>Enterococcus faecalis and E...
  44. pmc Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid
    Christian Theilacker
    Division of Infectious Disease, Department of Medicine, University Hospital Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Infect Immun 74:5703-12. 2006
    A teichoic acid (TA)-like polysaccharide in Enterococcus faecalis has previously been shown to induce opsonic antibodies that protect against bacteremia after active and passive immunization...
  45. pmc The transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood
    Heidi C Vebø
    Laboratory of Microbial Gene Technology and Food Microbiology, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
    PLoS ONE 4:e7660. 2009
    b>Enterococcus faecalis plays a dual role in human ecology, predominantly existing as a commensal in the alimentary canal, but also as an opportunistic pathogen that frequently causes nosocomial infections like bacteremia...
  46. ncbi In vitro assessment of the antimicrobial action and the mechanical ability of chlorhexidine gel as an endodontic irrigant
    C C Ferraz
    School of Dentistry of Piracicaba, University of Campinas, Brazil
    J Endod 27:452-5. 2001
    ..First the ability of chlorhexidine gel to disinfect root canals contaminated in vitro with Enterococcus faecalis was investigated...
  47. ncbi Control of microorganisms in vitro by calcium hydroxide pastes
    C Estrela
    Department of Endodontics, ,
    Int Endod J 34:341-5. 2001
    ..CONCLUSIONS: Under the conditions of this study, the various vehicles associated with calcium hydroxide pastes did not influence the time required for microbial inactivation...
  48. pmc High-resolution visualization of the microbial glycocalyx with low-voltage scanning electron microscopy: dependence on cationic dyes
    Stanley L Erlandsen
    Deptartment of Genetics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Histochem Cytochem 52:1427-35. 2004
    ..electron microscopy (LVSEM) to visualize the glycocalyx in two microbial models (Klebsiella pneumoniae and Enterococcus faecalis biofilms) at high resolution, and also the dependence on fixation containing polycationic dyes for its ..
  49. ncbi The anti-microbial effect against enterococcus faecalis and the compressive strength of two types of mineral trioxide aggregate mixed with sterile water or 2% chlorhexidine liquid
    Dennis M Holt
    Department of Endodontics, Wilford Hall Medical Center, Lackland AFB, Texas 78236 5346, USA
    J Endod 33:844-7. 2007
    ..effect test was accomplished by placing freshly mixed MTA samples on agar plates inoculated with Enterococcus faecalis and comparing the zones of inhibition at 24 hours...
  50. ncbi Disinfection of gutta-percha cones with chlorhexidine and sodium hypochlorite
    Brenda Paula Figueiredo de Almeida Gomes
    Department of Restorative Dentistry, State University of Campinas, Piracicaba, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:512-7. 2005
    ....
  51. ncbi Survival of Enterococcus faecalis in root canals ex vivo
    C M Sedgley
    Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Int Endod J 38:735-42. 2005
    The hypotheses tested in this study were that: (i) Enterococcus faecalis can survive long-term entombment in root filled teeth without additional nutrients, (ii) initial cell density influences the survival of E...
  52. pmc The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reaction
    José L Llácer
    Instituto de Biomedicina de Valencia IBV CSIC, C Jaime Roig 11, 46010 Valencia, Spain
    J Bacteriol 189:1254-65. 2007
    b>Enterococcus faecalis makes ATP from agmatine in three steps catalyzed by agmatine deiminase (AgDI), putrescine transcarbamylase (PTC), and carbamate kinase (CK). An antiporter exchanges putrescine for agmatine. We have cloned the E...
  53. pmc Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans
    Ransome van der Hoeven
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS Pathog 7:e1002453. 2011
    ..elegans intestine upon exposure to the human bacterial pathogens, Enterococcus faecalis and Pseudomonas aeruginosa...
  54. pmc Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activitie
    J J Ferretti
    J Bacteriol 167:631-8. 1986
    ..These data suggest that the gene specifying the AAC(6')-APH(2") resistance enzyme arose as a result of a gene fusion...
  55. pmc From commensal to pathogen: translocation of Enterococcus faecalis from the midgut to the hemocoel of Manduca sexta
    Katie L Mason
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
    MBio 2:e00065-11. 2011
    ..b>Enterococcus faecalis is a commensal of the gastrointestinal tract; however, Enterococcus spp...
  56. pmc Intra- and interspecies genomic transfer of the Enterococcus faecalis pathogenicity island
    Jenny A Laverde Gomez
    Wernigerode Branch, Robert Koch Institute, Wernigerode, Germany
    PLoS ONE 6:e16720. 2011
    ..b>Enterococcus faecalis harbours a pathogenicity island (PAI) of 153 kb containing several virulence factors including the ..
  57. pmc SlyA is a transcriptional regulator involved in the virulence of Enterococcus faecalis
    Charlotte Michaux
    Laboratoire de Microbiologie de l Environnement, EA 956 soutenue par l INRA, IFR 146, Universite de Caen, 14032 Caen Cedex, France
    Infect Immun 79:2638-45. 2011
    Phylogenetic analysis of the crystal structure of the Enterococcus faecalis SlyA (EF_3002) transcriptional factor places it between the SlyA and MarR regulator subfamilies...
  58. ncbi Antimicrobial activity of maleic acid and combinations of cetrimide with chelating agents against Enterococcus faecalis biofilm
    Carmen María Ferrer-Luque
    Department of Preventive and Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 36:1673-5. 2010
    ..The purpose of the present study was therefore to evaluate the in vitro capacity of maleic acid in eradicating Enterococcus faecalis biofilms and to evaluate the combinations of cetrimide with maleic acid, citric acid, and EDTA.
  59. pmc Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis
    Lance R Thurlow
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Infect Immun 78:4936-43. 2010
    The Gram-positive pathogen Enterococcus faecalis is a leading agent of nosocomial infections, including urinary tract infections, surgical site infections, and bacteremia. Among the infections caused by E...
  60. ncbi Enterococcus faecalis--a mechanism for its role in endodontic failure
    R M Love
    Department of Oral Health, University of Otago School of Dentistry, Dunedin, New Zealand
    Int Endod J 34:399-405. 2001
    ..The aim of this study was to identify a possible mechanism that would explain how E. faecalis could survive and grow within dentinal tubules and reinfect an obturated root canal...
  61. ncbi Virulence factors of Enterococcus faecalis and Enterococcus faecium blood culture isolates
    H A Elsner
    Abteilung für Transfusionsmedizin, Medizinische Hochschule Hannover, Germany
    Eur J Clin Microbiol Infect Dis 19:39-42. 2000
    Known and potential virulence factors of enterococcal blood culture isolates were studied using 89 Enterococcus faecalis and 24 Enterococcus faecium isolates. The prevalence of the respective factors was (Enterococcus faecalis vs...
  62. ncbi clpB, a class III heat-shock gene regulated by CtsR, is involved in thermotolerance and virulence of Enterococcus faecalis
    Naira Elane Moreira de Oliveira
    Instituto de Microbiologia Paulo de Góes, Bloco I, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitaria, 21491 902, Rio de Janeiro, RJ, Brazil
    Microbiology 157:656-65. 2011
    Here, we transcriptionally and phenotypically characterized the clpB gene from Enterococcus faecalis. Northern blot analysis identified a monocistronic mRNA strongly induced at 48 and 50 °C...
  63. ncbi Cell-cell communication in gram-positive bacteria
    G M Dunny
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Annu Rev Microbiol 51:527-64. 1997
    ..The microbial processes controlled by extracellular signaling include the expression of virulence factors, the expression of gene transfer functions, and the production of antibiotics...
  64. pmc The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability to respond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal
    Neuza Teixeira
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127, 2781 901 Oeiras, Portugal
    Microbiology 158:519-28. 2012
    The concomitant presence of a complete fsr quorum-sensing system and gelE-sprE operons in Enterococcus faecalis is known to be essential for the detection of gelatinase activity...
  65. pmc Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors
    Lionel Rigottier-Gois
    INRA, UMR1319 MICALIS, Jouy en Josas, France
    PLoS ONE 6:e29023. 2011
    ..Among those, Enterococcus faecalis is a leading cause of hospital-acquired infections associated with life-threatening issues and increased ..
  66. pmc Bicarbonate enhances expression of the endocarditis and biofilm associated pilus locus, ebpR-ebpABC, in Enterococcus faecalis
    Agathe Bourgogne
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, 6431 Fannin, Houston, Texas 77030, USA
    BMC Microbiol 10:17. 2010
    ..transcriptional regulator family, and showed that it is important for transcriptional activation of the Enterococcus faecalis endocarditis and biofilm associated pilus operon, ebpABC...
  67. ncbi Comparison of 5.25% sodium hypochlorite, MTAD, and 2% chlorhexidine in the rapid disinfection of polycaprolactone-based root canal filling material
    Mathew J Royal
    Department of Endodontics, College of Dentistry, University of Iowa, Iowa City, Iowa, USA
    J Endod 33:42-4. 2007
    ..Resilon pellets were randomly selected, contaminated with Enterococcus faecalis, and disinfected with 5.25% sodium hypochlorite, MTAD, or 2% chlorhexidine...
  68. ncbi A comparison of the antimicrobial efficacy of NaOCl/Biopure MTAD versus NaOCl/EDTA against Enterococcus faecalis
    Patricia Kho
    Oregon Health and Science University, OHSU School of Dentistry, Portland, 97201, USA
    J Endod 32:652-5. 2006
    ..25% NaOCl/15% EDTA in the apical 5 mm of roots infected with Enterococcus faecalis. Bilaterally matched human teeth were sterilized and inoculated with E. faecalis...
  69. pmc Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence
    X Qin
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 68:2579-86. 2000
    Three agr-like genes (fsrA, fsrB, and fsrC, for Enterococcus faecalis regulator) were found upstream of the previously reported gelatinase gene (gelE) and a downstream putative serine protease gene (sprE; accession number Z12296) of ..
  70. pmc Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis
    Margrete Solheim
    Laboratory of Microbial Gene Technology and Food Microbiology, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, N 1432 As, Norway
    BMC Microbiol 11:3. 2011
    ..The failure to identify pathogen-specific genes in Enterococcus faecalis has led to a hypothesis where the virulence of different strains may be linked to strain-specific genes, ..
  71. pmc Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
    Irina G Sava
    Division of Infectious Diseases, University Medical Center Freiburg, 79106 Freiburg, Germany
    J Biol Chem 284:18194-201. 2009
    b>Enterococcus faecalis is among the most important nosocomial pathogens. The intestinal mucosa is considered to be the main site used by these bacteria for entrance and dissemination...
  72. ncbi The susceptibility of starved, stationary phase, and growing cells of Enterococcus faecalis to endodontic medicaments
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Oslo, Norway
    J Endod 31:380-6. 2005
    The purpose of this investigation was to compare the susceptibility of cells of Enterococcus faecalis during exponential growth, stationary phase and starvation phase to three endodontic medicaments. E...
  73. pmc C-terminal WxL domain mediates cell wall binding in Enterococcus faecalis and other gram-positive bacteria
    Sophie Brinster
    Unité des Bactéries Lactiques et Pathogènes Opportunistes, INRA, Jouy en Josas, France
    J Bacteriol 189:1244-53. 2007
    Analysis of the genome sequence of Enterococcus faecalis clinical isolate V583 revealed novel genes encoding surface proteins...
  74. ncbi An in vitro comparison of the antimicrobial effects of various endodontic medicaments on Enterococcus faecalis
    Joshua M Davis
    Department of Graduate Endodontics, Marquette University, Milwaukee, WI 53233, USA
    J Endod 33:567-9. 2007
    ..25% sodium hypochlorite (NaOCl) against Enterococcus faecalis (American Type Culture Collection 4082). Eighteen Petri dishes of BHI agar were inoculated with E faecalis...
  75. ncbi Hidden pathogens uncovered: metagenomic analysis of urinary tract infections
    C Imirzalioglu
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    Andrologia 40:66-71. 2008
    ..15%), followed by miscellaneous bacteria (23.03%), and by Enterococcus faecalis (19.39%). A large fraction of fastidious and anaerobic bacteria (22...
  76. pmc Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium
    Pauline Yoong
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 186:4808-12. 2004
    b>Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E...
  77. pmc The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall
    Lynn E Hancock
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 99:1574-9. 2002
    With the goal of identifying and characterizing traits of Enterococcus faecalis that play key roles in human disease, we identified an operon specifying synthesis of a capsular carbohydrate of the type most commonly expressed by clinical ..
  78. ncbi Biofilm formation by enterococci
    Jamal A Mohamed
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Med Microbiol 56:1581-8. 2007
    ..The two most common enterococci species are Enterococcus faecalis and Enterococcus faecium...
  79. pmc Comparative genomics of Enterococcus faecalis from healthy Norwegian infants
    Margrete Solheim
    Laboratory of Microbial Gene Technology and Food Microbiology, Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
    BMC Genomics 10:194. 2009
    b>Enterococcus faecalis, traditionally considered a harmless commensal of the intestinal tract, is now ranked among the leading causes of nosocomial infections. In an attempt to gain insight into the genetic make-up of commensal E...
  80. pmc Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families
    Elizabeth M Fozo
    Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 38:3743-59. 2010
    ..Our results suggest that type I toxin-antitoxin modules are much more widely distributed among bacteria than previously appreciated...
  81. ncbi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
    ..mutant of a putative glucosyltransferase designated biofilm-associated glycolipid synthesis A (bgsA) in Enterococcus faecalis 12030...
  82. ncbi Virulence factors of Enterococcus faecalis: relationship to endodontic disease
    Guven Kayaoglu
    Gazi University, Faculty of Dentistry, Department of Endodontics and Conservative Treatment, 82 Sokak 06510 Emek, Ankara, Turkey
    Crit Rev Oral Biol Med 15:308-20. 2004
    b>Enterococcus faecalis is a micro-organism that can survive extreme challenges...
  83. ncbi A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to production of biofilm and prolonged bacteremia in mice
    Markus Hufnagel
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 189:420-30. 2004
    A biofilm-negative transposon mutant was created from an Enterococcus faecalis strain that produces a lot of biofilm...
  84. pmc Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis
    P M Schlievert
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312, USA
    Infect Immun 66:218-23. 1998
    ..of enterococcal aggregation substance (AS) and enterococcal binding substance (EBS) in rabbit models of Enterococcus faecalis cardiac infections...
  85. ncbi Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
    Danielle A Garsin
    Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 300:1921. 2003
  86. pmc Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones
    Stéphanie Arsène
    CHU de Caen, Service de Microbiologie, Avenue Cote de Nacre, 14033 Caen Cedex, France
    Antimicrob Agents Chemother 51:3254-8. 2007
    ..We have identified in the genome of Enterococcus faecalis V583 a qnr-like gene, named E. faecalis qnr (qnr(E...
  87. pmc Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis
    Preeti M Tendolkar
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    J Bacteriol 188:2063-72. 2006
    Enterococci are opportunistic pathogens and among the leading causes of nosocomial infections. Enterococcus faecalis, the dominant species among infection-derived isolates, has recently been recognized as capable of forming biofilms on ..
  88. pmc Full activation of Enterococcus faecalis gelatinase by a C-terminal proteolytic cleavage
    Maria Florencia Del Papa
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 189:8835-43. 2007
    ..One of the well-studied virulence factors of Enterococcus faecalis is a secreted bacterial protease, termed gelatinase, which has been shown to contribute to the process of ..
  89. ncbi Efficacy of various intracanal medicaments against Enterococcus faecalis in primary teeth: an in vivo study
    Ozant Oncag
    Ege University, Faculty of Dentistry Department of Pedodontics, BornovaIzmir, Turkey
    J Clin Pediatr Dent 30:233-7. 2006
    ..three intracanal medicaments (Ca(OH)2, 1% chlorhexidine gel and 1% chlorhexidine gel with Ca(OH)2 against Enterococcus faecalis in necrotic primary teeth...
  90. pmc Porcine-origin gentamicin-resistant Enterococcus faecalis in humans, Denmark
    Jesper Larsen
    Department of Disease Biology, University of Copenhagen, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Emerg Infect Dis 16:682-4. 2010
    During 2001-2002, high-level gentamicin-resistant (HLGR) Enterococcus faecalis isolates were detected in 2 patients in Denmark who had infective endocarditis and in pigs and pork...
  91. ncbi An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis
    R S Hems
    Unit of Endodontology, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, UK
    Int Endod J 38:22-9. 2005
    To evaluate the potential of ozone as an antibacterial agent using Enterococcus faecalis as the test species.
  92. ncbi Transcriptional control of sex-pheromone-inducible genes on plasmid pAD1 of Enterococcus faecalis and sequence analysis of a third structural gene for (pPD1-encoded) aggregation substance
    D Galli
    Lehrstuhl fur Mikrobiologie, Universitat Munchen, Germany
    Mol Microbiol 6:1297-308. 1992
    ..Its main statement is that only in the presence of cAD1 can the gene traE1 be transcribed. The positive regulatory factor TraE1 then can trigger expression of the structural genes sea1 and asa1...
  93. ncbi Clinical isolates of Enterococcus faecalis aggregate human platelets
    Magnus Rasmussen
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden
    Microbes Infect 12:295-301. 2010
    ..Here we report for the first time that many clinical isolates of Enterococcus faecalis, a common pathogen in infective endocarditis, aggregate human platelets...
  94. ncbi Effect of banning vancomycin analogue avoparcin on vancomycin-resistant enterococci in chicken farms in Taiwan
    Tsai Ling Lauderdale
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan
    Environ Microbiol 9:819-23. 2007
    ....
  95. pmc Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR
    Janet M Manson
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
    Antimicrob Agents Chemother 48:3743-8. 2004
    Bacitracin resistance (bacitracin MIC, >/=256 microg ml(-1)) has been reported in Enterococcus faecalis, and in the present study we report on the genetic basis for this resistance...
  96. ncbi In vitro antibacterial effect of calcium hydroxide combined with chlorhexidine or iodine potassium iodide on Enterococcus faecalis
    Eva K Sirén
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Eur J Oral Sci 112:326-31. 2004
    ..b>Enterococcus faecalis is often associated with persistent endodontic infections...
  97. ncbi Prevalence, phenotype and genotype of oral enterococci
    C M Sedgley
    Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Oral Microbiol Immunol 19:95-101. 2004
    ..0027). All enterococcal isolates were identified as Enterococcus faecalis. Viable counts ranged from 1 x 10 to 6 x 103 colony forming units per mL of oral rinse sample...
  98. pmc A cluster of genes involved in polysaccharide biosynthesis from Enterococcus faecalis OG1RF
    Y Xu
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 66:4313-23. 1998
    Our previous work identified a cosmid clone containing a 43-kb insert from Enterococcus faecalis OG1RF that produced a nonprotein antigen in Escherichia coli. In the present work, we studied this clone in detail...
  99. ncbi Enterococcal cytolysin: activities and association with other virulence traits in a pathogenicity island
    Nathan Shankar
    College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Int J Med Microbiol 293:609-18. 2004
    ..The cytolysin operon within the E. faecalis pathogenicity island is associated with other virulence determinants, including aggregation substance and enterococcal surface protein, Esp...
  100. pmc Differences in antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium strains isolated from farm and pet animals
    P Butaye
    Laboratory of Veterinary Bacteriology and Mycology, Department of Pathology, Bacteriology, and Poultry Diseases, Faculty of Veterinary Medicine, University of Ghent, B 9820 Merelbeke, Belgium
    Antimicrob Agents Chemother 45:1374-8. 2001
    The prevalence of acquired resistance in 146 Enterococcus faecium and 166 Enterococcus faecalis strains from farm and pet animals, isolated in 1998 and 1999 in Belgium, against antibiotics used for growth promotion and for therapy was ..
  101. pmc Genotyping of Enterococcus faecalis and Enterococcus faecium isolates by use of a set of eight single nucleotide polymorphisms
    I U Rathnayake
    Cell and Molecular Biosciences, Faculty of Science and Technology, Queensland University of Technology, 2 George St, Brisbane, Queensland 4001, Australia
    J Clin Microbiol 49:367-72. 2011
    A single nucleotide polymorphism (SNP) genotyping method for Enterococcus faecalis and Enterococcus faecium was developed using the "Minimum SNPs" program. SNP sets were interrogated using allele-specific real-time PCR...

Research Grants63

  1. MECHANISMS INVOLVED IN FLAVIN-LINKED OXYGEN METABOLISM
    Al Claiborne; Fiscal Year: 2005
    ..severe human pathogen Streptococcus pyogenes, (2) NADH peroxidase (Npx; NADH + H2O2 - to NAD+ + 2H2O) from Enterococcus faecalis, and (3) alpha-glycerophosphate oxidase (GlpO; alpha-glycerophosphate + O2 - to dihydroxyacetone phosphate ..
  2. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..In this grant we link the oxidative physiology of this common intestinal commensal, Enterococcus faecalis, to the origin of chromosomal instability (CIN). Among intestinal commensals E...
  3. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..aeruginosa, S. aureus, and S. epidermidis, three isolates each of Escherichia coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida albicans also demonstrate ..
  4. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..our proprietary formulation to understand thresholds for effective biofilm prevention (Proteus mirabilis, Enterococcus faecalis, and Staphylococcus epidermidis);(2) to understand the light emission requirements at 590nm to ..
  5. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ..Selective colonization of germ-free IL-10-/- mice with Escherichia coli or Enterococcus faecalis induces different phenotypes of colitis for each bacteria. E. coli and E...
  6. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and Clostridium difficile in culture...
  7. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..g. E. Coli, Enterococcus Faecalis, MS2 bacteriophage Poliovirus, Cryptosporidium parvum, Legionelle pneumophila, and Salmonella enterica ..
  8. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..etiologic agents of catheter-related and surgical site infections, namely Staphylococcus aureus and Enterococcus faecalis. Not only are these bacteria prevalent in biofilm-related infections, the antimicrobial resistance ..
  9. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..mice selectively colonized (monoassociated) with non-pathogenic strains of Escherichia coli (NC101) or Enterococcus faecalis (OG1RF) develop different phenotypes of colitis with clear regional and kinetic differences, and that ..
  10. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..epidermidis, Enterococcus faecalis, E...
  11. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    The high prevalence of nosocomial infections by multidrug-resistant Enterococcus faecalis presents both a treatment and an infection control challenge in the hospital setting...
  12. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae...
  13. Role of Bacteria in Colitis-associated Colon Cancer
    Christian Jobin; Fiscal Year: 2013
    ..coli) and Enterococcus faecalis (E. faecalis) monoassociated Il10-/- mice, tumor numbers were strongly enhanced in the E...
  14. Inflammatory Effect of Enteric Bacterial-Mediated Intestinal Permeability
    IAN MICHAEL CARROLL; Fiscal Year: 2013
    ..To achieve this aim we will use wild-type and mutant Enterococcus faecalis OG1RF strains that lack gelatinase or serine protease activity, and wild-type and mutant Bifidobacterium ..
  15. ROLE OF TOXINS IN ENDOPHTHALMITIS
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2012
    ..Antibiotic resistance among Staphylococcus aureus and Enterococcus faecalis has become an issue of considerable public health concern...
  16. HYBRID MOLECULES DESIGNED TO ENHANCE ANTIBIOTIC ACTIVITY
    George Wright; Fiscal Year: 2009
    ..The worldwide resurgence of antibiotic resistant Gram-positive bacteria, especially Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae, has stimulated discovery of novel agents that can ..
  17. Biofilms and Enterococcus faecalis Biology
    Gary M Dunny; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Enterococcus faecalis iis one of the top three most frequently-isolated species from hospital- associated infections of compromised patients and it can cause a highly fatal form of endocarditis...
  18. Molecular Mechanisms Of Daptomycin Resistance In Enterococci
    CESAR AUGUSTO ARIAS; Fiscal Year: 2013
    ..cell envelope ultrastructural analysis of VRE clinical strain pairs of DAP-susceptible and DAP-resistant Enterococcus faecalis (VREfs) and E...
  19. Oral streptococcal-enterococcal peptide-mediated intercellular communication
    M Margaret Vickerman; Fiscal Year: 2012
    ..b>Enterococcus faecalis, predominantly a component of gut microflora, has emerged as an opportunistic pathogen, known to carry ..
  20. Metagenetic analysis of microbial community behavior
    JO E HANDELSMAN; Fiscal Year: 2010
    ..We will identify genes involved in invasion of the community by Enterococcus faecalis, and determine whether the same genes are involved in exclusion of invaders when E...
  21. Role of type IV secretion-mediated protein translocation in E. faecalis
    Peter J Christie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Enterococcus faecalis is a Gram-positive opportunistic pathogen and causative agent of urinary tract and wound infections, bacteremia, and infectious endocarditis...
  22. Defining the Role of WxL Proteins in Enterococcus faecium
    JESSICA RHEA GALLOWAY-PENA; Fiscal Year: 2013
    ..Proteins containing this domain have been implicated as important in peritonitis infections caused by Enterococcus faecalis and aggregation in Lactobacillus coryniformis. My preliminary data have shown that the WxL proteins of E...
  23. CCL1 gene therapy to inhibit bacterial translocation in acute radiation syndromes
    Fujio Suzuki; Fiscal Year: 2013
    ..Gut-associated sepsis induced by Enterococcus faecalis oral infection is markedly mitigated in WBI-mice multiply treated with CCL1 antisense ODN starting two to ..
  24. Mechanism of Gene Regulation by RNA-Binding ANTAR Proteins
    Wade Winkler; Fiscal Year: 2011
    One characteristic that contributes to Enterococcus faecalis[unreadable]s success as the second or third leading cause of hospital-acquired infection in the U.S...
  25. Interactions of a commensal bacterium with the intestinal mucosal surface
    Breck A Duerkop; Fiscal Year: 2012
    ..b>Enterococcus faecalis is a predominant member of the mammalian intestinal microbiota that can opportunistically disseminate from ..
  26. Genetic Functions of an Enterococcal R Factor
    Gary M Dunny; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Enterococcus faecalis is a major cause of hospital-acquired infections and also plays a key role in the dissemination of antibiotic resistance and virulence genes to other bacterial pathogens...
  27. Novel Strategy for Endophthalmitis Drug Targets
    KELLI LEA PALMER; Fiscal Year: 2011
    ..b>Enterococcus faecalis causes an unusually destructive and drug-resistant form of endophthalmitis that often leads to blindness...
  28. Host immune response to E. faecalis bioflim
    Nathan Shankar; Fiscal Year: 2011
    ..Hospital-acquired infections by Enterococcus faecalis, especially those associated with intravascular catheters, biliary stents and other implants have ..
  29. Therapeutic potential of Enterococcus faecalis bacteriophage phiEf11
    Roy H Stevens; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The emergence of Enterococcus faecalis as a significant human pathogen, with many strains becoming resistant to antibiotics emphasizes the need to develop new and effective means of controlling ..
  30. Functional Characterization of the Site Specific Residues in Mutacin 1140
    James Smith; Fiscal Year: 2009
    ..Gram positive bacteria which it has been tested, including multidrug resistant Staphylococcus aureus and Enterococcus faecalis. It is also active against some Gram negative pathogens...
  31. Enterococcal Pathogenesis:Role of Cytolysin
    Michael S Gilmore; Fiscal Year: 2013
    ..work, as well as the work of others, has shown that one of the factors that makes hospital isolate of Enterococcus faecalis more virulent is a toxin termed "cytolysin." The E...
  32. Modeling CRISPR to Preserve Antibiotics
    Michael S Gilmore; Fiscal Year: 2013
    ..R21 application, we propose to quantify the level of defense against plasmid and phage entry into Enterococcus faecalis accorded by the CRISPR locus, and to model using varying parameters, the tension between antibiotic ..
  33. Modeling Pheromone Induced Plasmid and Drug Resistance Transfer
    Wei Shou Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary Enterococcus faecalis is a bacterium found in the intestine of humans as well as in a wide variety of ecological niches...
  34. CRISPR defense and acquired antibiotic resistance in Enterococcus faecalis
    KELLI LEA PALMER; Fiscal Year: 2013
    ..The proposed research will focus on Enterococcus faecalis, which since the 1980s has gained increasing notoriety from association with hospital-acquired infections ..
  35. Intrinsic Resistance to antimicrobials in Enterococcus faecalis
    Christopher J Kristich; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Antibiotic-resistant Gram-positive bacteria, such as Enterococcus faecalis and Staphylococcus aureus, are major causes of hospital-acquired infections. E...
  36. Enterococcus niche formation in the GI tract
    Nita H Salzman; Fiscal Year: 2013
    ..One member of this ecosystem is Enterococcus faecalis (EF), a "pathobiont" that normally lives symbiotically with its host, but also can invade the host and ..
  37. Syndecan and Bacterial Translocation in Shock and Trauma
    Carol Wells; Fiscal Year: 2006
    Normal enteric bacteria, such as Escherichia coli and Enterococcus faecalis, frequently cause complicating infections in patients with shock and trauma...
  38. Novel antibacterials targeting the 50S ribosomal subunit
    Joyce Sutcliffe; Fiscal Year: 2005
    ..caused by Gram-positive pathogens, a drug must cover Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Enterococcus faecium...
  39. ORGANIC NANOTUBES DESIGN AND BIOLOGICAL APPLICATIONS
    M Ghadiri; Fiscal Year: 2009
    ..in vivo (mice) activities against multidrug-resistant bacterial infections including vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA)...
  40. Bacterial-host dynamics at the intestinal mucosal interface
    Nita H Salzman; Fiscal Year: 2013
    ..One member of this ecosystem is Enterococcus faecalis (EF), a "pathobiont" that normally lives symbiotically with its host, but also can invade the host and ..
  41. Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
    Cynthia Stauffacher; Fiscal Year: 2007
    ..provided by applicant): It has recently been shown that a number of common human pathogens, including Enterococcus faecalis, Streptococcus pneumoniae and Staphylococcus aureus are dependent on enzymes in the mevalonate pathway for ..
  42. CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSIS
    Christopher Papasian; Fiscal Year: 2000
    ..It was observed that Enterococcus faecalis was a poor inducer of TNF in an in vitro system that examines TNF production in peritoneal macrophages...
  43. Intra-species regulatory functions of fsr
    Satish Pillai; Fiscal Year: 2004
    b>Enterococcus faecalis is a leading cause of endocarditis, nosocomial bacteremia and urinary tract infections...
  44. Peptide Pheromones in Enterococcal Plasmid Maintenance
    BETTINA BUTTARO; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Enterococcus faecalis plays a major role in the current antibiotic resistance crisis...
  45. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2003
    b>Enterococcus faecalis is a gram-positive, facultatively anaerobic, coccal bacterium that causes a variety of community- and hospital- acquired infections in humans, including infections of the blood, endocardium, genitourinary tract, ..
  46. ASM Conference on Cell-Cell Communication in Bacteria
    STEPHEN WINANS; Fiscal Year: 2001
    ..bioluminescence regulatory systems of Vibriofischeri and Vibrio harveyi, the conjugal transfer system of Enterococcus faecalis, the production of antibiotics by Streptomyces spp...
  47. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..microbial surface components which facilitate the binding of pathogens such as Staphylococcus aureus, Enterococcus faecalis, and B. burgdorferi to host cell adhesive matrix molecules...
  48. Enterococcus faecalis Gene Expression in Host Environments
    KRISTI FRANK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Enterococcus faecalis is a Gram-positive constituent of the gastrointestinal microflora and a significant cause of nosocomial infections. E...
  49. Invasion and Exclusion by Enterococcus faecalis in the Manduca gut community
    JO E HANDELSMAN; Fiscal Year: 2013
    ..The work has the potential to advance the field of microbial community ecology by providing a basis for deriving models about community behavior in the face of perturbation that may apply directly to human health. ..
  50. GENETIC ANALYSIS OF ENTEROCOCCI
    Barbara Murray; Fiscal Year: 2000
    ..and staphylococci, and the second or third most common cause of hospital acquired infections; among these, Enterococcus faecalis is the predominant species isolated...
  51. CAPSULAR POLYSACCHARIDES AND ENTEROCOCCAL INFECTIONS
    Johannes Huebner; Fiscal Year: 2002
    ..to understand the molecular, biochemical, and immunologic factors that contribute to the pathogenesis of Enterococcus faecalis and E.faecium infections, with special emphasis on multiply antibiotic-resistant enterococci...
  52. SEX PHEROMONE INDUCED PLASMID TRANSFER
    DON CLEWELL; Fiscal Year: 2002
    b>Enterococcus faecalis is an important opportunistic pathogen that is now the second leading cause of bacteremia and third leading cause of endocarditis in humans...
  53. Role of Enterococcal Polysaccharides in Virulence
    Johannes Huebner; Fiscal Year: 2006
    ..to understand the molecular, biochemical, and immunologic factors that contribute to the pathogenesis of Enterococcus faecalis and Enterococcus faecium infections...
  54. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010
    ..3) To determine whether pro-oxidant bacteria, Enterococcus faecalis and pro-inflammatory dextran sulfate sodium can increase oxidative stress, gene mutations, and cancer in ..
  55. MAINTENANCE OF ENTEROCOCCUS FAECALIS PLASMID PAD1
    KEITH WEAVER; Fiscal Year: 1992
    DESCRIPTION (Adapted from the investigator's abstract): The Enterococcus faecalis plasmid pAD1 is the prototype of a group of plasmids native to this organism which possess a unique mechanism of conjugative transfer...
  56. Genome-wide Dissection of c. elegans Innate Immunity
    Man Wah Tan; Fiscal Year: 2006
    ..elegans by several human bacterial pathogens - Pseudomonas aeruginosa, Salmonella enterica and Enterococcus faecalis - as a model. C...
  57. IDENTIFICATION OF NEW ANTIBIOTIC TARGETS USING BACS
    ROBERT HASELBECK; Fiscal Year: 2000
    ..of transposon mutagenesis and Bacterial Artificial Chromosomes (BACs) in Staphylococcus aureus and Enterococcus faecalis will yield cells that require BAC complementation of transposon mutations in essential genes...
  58. CONJUGATIVE TRANSPOSON TN 916
    DON CLEWELL; Fiscal Year: 1999
    ..The purpose of this study is to investigate the molecular basis of conjugative transposition of the Enterococcus faecalis tetracycline-resistance transposon Tn916...
  59. Regulation of Ethanolamine Utilization in E. Faecalis by an Atypical Riboswitch
    DANIELLE GARSIN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): One characteristic that contributes to Enterococcus faecalis's success as the second or third leading cause of hospital-acquired infection in the U.S...
  60. NEUTROPHIL SIGNALING & EFFECTOR RESPONSES IN BURN INJURY
    Masakatsu Goto; Fiscal Year: 2005
    ..focus on PMN signaling, cytokine expression and cell-cell interactions during burn injury complicated by Enterococcus faecalis infection...
  61. Bacterial interactions in biofilms
    Richard Hull; Fiscal Year: 2004
    ..We propose to study the gene expression of a clinical E. coli that is growing in a biofilm together with Enterococcus faecalis. Each of these bacterial species is a common cause of catheter associated UTI...
  62. Challenge Grant--Joint Ventures
    John Lonsdale; Fiscal Year: 2000
    ..and purified from several key pathogens, including Mycobacterium tuberculosis, Staphylococcus aureus and Enterococcus faecalis, and assays will be configured for high throughput screening (HTS)...
  63. Study of stability genes of E. faecalis plasmid pAD1
    KEITH WEAVER; Fiscal Year: 2006
    b>Enterococcus faecalis is a Gram-positive bacterium and a member of the normal flora of the intestinal tract...