staphylococcus aureus

Summary

Summary: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.

Top Publications

  1. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
  2. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  3. ncbi Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
    Binh An Diep
    Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
    Lancet 367:731-9. 2006
  4. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
  5. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
  6. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
  7. pmc Mobile genetic elements of Staphylococcus aureus
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT, 59840, USA
    Cell Mol Life Sci 67:3057-71. 2010
  8. pmc Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    Eili Klein
    Resources for the Future, Washington DC, USA
    Emerg Infect Dis 13:1840-6. 2007
  9. doi Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Nat Rev Microbiol 12:49-62. 2014
  10. doi Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    Rachel J Gorwitz
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 197:1226-34. 2008

Detail Information

Publications324 found, 100 shown here

  1. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
    b>Staphylococcus aureus is notorious for its ability to become resistant to antibiotics. Infections that are caused by antibiotic-resistant strains often occur in epidemic waves that are initiated by one or a few successful clones...
  2. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Macrophages exposed to Gram-positive Staphylococcus aureus or Listeria monocytogenes, however, required both ASC and cryopyrin to activate caspase-1 and secrete IL-..
  3. ncbi Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
    Binh An Diep
    Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
    Lancet 367:731-9. 2006
    USA300, a clone of meticillin-resistant Staphylococcus aureus, is a major source of community-acquired infections in the USA, Canada, and Europe...
  4. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
    b>Staphylococcus aureus is a frequent cause of infections in both the community and hospital. Worldwide, the increasing resistance of this pathogen to various antibiotics complicates treatment of S aureus infections...
  5. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
    Infections caused by community-acquired (CA)-methicillin--resistant Staphylococcus aureus (MRSA) have been reported worldwide...
  6. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
    ..NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria...
  7. pmc Mobile genetic elements of Staphylococcus aureus
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT, 59840, USA
    Cell Mol Life Sci 67:3057-71. 2010
    Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host...
  8. pmc Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    Eili Klein
    Resources for the Future, Washington DC, USA
    Emerg Infect Dis 13:1840-6. 2007
    Hospital-acquired infections with Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA) infections, are a major cause of illness and death and impose serious economic costs on patients and hospitals...
  9. doi Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
    Timothy J Foster
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Nat Rev Microbiol 12:49-62. 2014
    b>Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan...
  10. doi Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    Rachel J Gorwitz
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 197:1226-34. 2008
    b>Staphylococcus aureus is a common cause of infection, particularly in persons colonized by this organism. Virulent strains of methicillin-resistant S. aureus (MRSA) have emerged in the general community.
  11. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
    ..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria ..
  12. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
    Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been considered a health care-associated pathogen in patients with established risk factors...
  13. pmc Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells
    Robin R Craven
    Department of Medicine Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e7446. 2009
    Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) causes severe necrotizing infections of the skin, soft tissues, and lungs...
  14. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are predominantly those affecting skin and soft tissues...
  15. pmc Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions
    Karen E Beenken
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Infect Immun 80:1634-8. 2012
    Recent studies suggest that extracellular DNA promotes biofilm formation in Staphylococcus aureus and, conversely, that extracellular nucleases limit the ability to form a biofilm. S...
  16. pmc Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein
    Maria A Schumacher
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201 3098, USA
    EMBO J 21:3546-56. 2002
    ..of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution, respectively...
  17. pmc Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions
    Yoko Kondo
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 51:264-74. 2007
    Staphylococcal cassette chromosome mec (SCCmec) typing, in combination with genotyping of the Staphylococcus aureus chromosome, has become essential for defining methicillin-resistant S. aureus (MRSA) clones in epidemiological studies...
  18. pmc How Staphylococcus aureus biofilms develop their characteristic structure
    Saravanan Periasamy
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:1281-6. 2012
    ..PSM) surfactant peptides as key biofilm structuring factors in the premier biofilm-forming pathogen Staphylococcus aureus. We provide evidence that all known PSM classes participate in structuring and detachment processes...
  19. pmc sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4
    Malcolm J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, England S10 2TN
    J Bacteriol 184:5457-67. 2002
    The accessory sigma factor sigmaB controls a general stress response that is thought to be important for Staphylococcus aureus survival and may contribute to virulence...
  20. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
    A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus. The sequences of internal fragments of seven housekeeping genes were obtained for 155 S...
  21. pmc Within-host evolution of Staphylococcus aureus during asymptomatic carriage
    Tanya Golubchik
    Department of Statistics, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 8:e61319. 2013
    b>Staphylococcus aureus is a major cause of healthcare associated mortality, but like many important bacterial pathogens, it is a common constituent of the normal human body flora. Around a third of healthy adults are carriers...
  22. pmc Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype
    Patrick Houston
    School of Biomolecular and Biomedical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Infect Immun 79:1153-65. 2011
    b>Staphylococcus aureus clinical isolates are capable of producing at least two distinct types of biofilm mediated by the fibronectin-binding proteins (FnBPs) or the icaADBC-encoded polysaccharide intercellular adhesin (PIA)...
  23. pmc Staphylococcal biofilm disassembly
    Blaise R Boles
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, MI 48109, USA
    Trends Microbiol 19:449-55. 2011
    b>Staphylococcus aureus and Staphylococcus epidermidis are a frequent cause of biofilm-associated infections that are a tremendous burden on our healthcare system...
  24. pmc Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR
    Benjamin P Howden
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    PLoS Pathog 7:e1002359. 2011
    Antimicrobial resistance in Staphylococcus aureus is a major public health threat, compounded by emergence of strains with resistance to vancomycin and daptomycin, both last line antimicrobials...
  25. pmc Selenium nanoparticles inhibit Staphylococcus aureus growth
    Phong A Tran
    Physics Department, Brown University, Providence, RI, USA
    Int J Nanomedicine 6:1553-8. 2011
    b>Staphylococcus aureus is a key bacterium commonly found in numerous infections. S. aureus infections are difficult to treat due to their biofilm formation and documented antibiotic resistance...
  26. ncbi Genome and virulence determinants of high virulence community-acquired MRSA
    Tadashi Baba
    Department of Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lancet 359:1819-27. 2002
    A new type of meticillin-resistant Staphylococcus aureus (MRSA), designated community-acquired MRSA, is becoming increasingly noticeable in the community, some strains of which cause fatal infections in otherwise healthy individuals...
  27. pmc Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database
    Linda K McDougal
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:5113-20. 2003
    Oxacillin-resistant Staphylococcus aureus (ORSA) is a virulent pathogen responsible for both health care-associated and community onset disease...
  28. doi Preventing surgical-site infections in nasal carriers of Staphylococcus aureus
    Lonneke G M Bode
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 362:9-17. 2010
    Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk.
  29. pmc Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation
    Katherine J Lauderdale
    Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Infect Immun 77:1623-35. 2009
    b>Staphylococcus aureus is a proficient biofilm former on host tissues and medical implants. We mutagenized S...
  30. pmc Agr-mediated dispersal of Staphylococcus aureus biofilms
    Blaise R Boles
    Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 4:e1000052. 2008
    The agr quorum-sensing system of Staphylococcus aureus modulates the expression of virulence factors in response to autoinducing peptides (AIPs). Recent studies have suggested a role for the agr system in S...
  31. doi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    Persistent nasal carriers have an increased risk of Staphylococcus aureus infection, whereas intermittent carriers and noncarriers share the same low risk...
  32. pmc Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation
    Caitriona M Guinane
    The Roslin Institute and Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Genome Biol Evol 2:454-66. 2010
    ..For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant plasma, reported over 60 years ago, led to the description of small ..
  33. doi The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
    J Infect Dis 197:1523-30. 2008
    The epidemic character of community-associated methicillin-resistant Staphylococcus aureus, especially the geographically widespread clone USA300, is poorly understood...
  34. pmc NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:12873-8. 2009
    b>Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia...
  35. pmc Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
    Benjamin P Howden
    Department of Infectious Diseases, Austin Health, Victoria, Australia
    Clin Microbiol Rev 23:99-139. 2010
    The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) over the past decade has provided a challenge to diagnostic microbiologists to detect these ..
  36. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
    Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined.
  37. ncbi Autoinduction and signal transduction in the regulation of staphylococcal virulence
    Richard P Novick
    Program in Molecular Pathogenesis, Skirball Institute, Department of Microbiology, New York University School of Medicine, 10016, USA
    Mol Microbiol 48:1429-49. 2003
    The accessory genes of Staphylococcus aureus, including those involved in pathogenesis, are controlled by a complex regulatory network that includes at least four two-component systems, one of which, agr, is a quorum sensor, an ..
  38. ncbi Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore
    L Song
    Department of Biochemistry, University of Chicago, 920 East 58 Street, Chicago, IL 60637, USA
    Science 274:1859-66. 1996
    The structure of the Staphylococcus aureus alpha-hemolysin pore has been determined to 1.9 A resolution...
  39. ncbi Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002
    Matthew J Kuehnert
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 193:172-9. 2006
    b>Staphylococcus aureus is a common cause of disease, particularly in colonized persons. Although methicillin-resistant S. aureus (MRSA) infection has become increasingly reported, population-based S...
  40. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia...
  41. ncbi Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat
    Hajo Grundmann
    Centre for Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Lancet 368:874-85. 2006
    b>Staphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25-30% of healthy people...
  42. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  43. doi Spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry
    H Hasman
    Technical University of Denmark, National Food Institute, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Vet Microbiol 141:326-31. 2010
    ..In conclusion, strains of MSSA CC398 were commonly present in pigs but not present at all in the other reservoirs tested...
  44. doi Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia
    Christopher P Montgomery
    Department of Pediatrics, Section of Critical Care Medicine, University of Chicago, Illinois 60637, USA
    J Infect Dis 198:561-70. 2008
    The predominant genetic background of community-associated methicillin-resistant Staphylococcus aureus has transitioned from USA400 to USA300 in most US communities. The explanation for this shift is unclear...
  45. ncbi Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine, Carl Gustav Carus at the Technical University of Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Vet Microbiol 125:128-40. 2007
    b>Staphylococcus aureus is a common pathogen which can colonise and infect not only man, but also domestic animals. Especially, infection of cattle is of high economic relevance as S. aureus is an important causal agent of bovine mastitis...
  46. pmc The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation
    S E Cramton
    Mikrobielle Genetik, Universitat Tubingen, D 72076 Tubingen, Germany
    Infect Immun 67:5427-33. 1999
    ..We have investigated a variety of Staphylococcus aureus strains and find that all strains tested contain the ica locus and that several can form biofilms in vitro...
  47. doi Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 9:215-22. 2011
    b>Staphylococcus aureus bacteraemia remains very difficult to treat, and a large proportion of cases result in potentially lethal metastatic infection...
  48. ncbi Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic
    J Harder
    Clinical Research Unit, Department of Dermatology, University Hospital Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    J Biol Chem 276:5707-13. 2001
    ..growing public health problem of infections caused by multiresistant Gram-positive bacteria, in particular Staphylococcus aureus, prompted us to screen human epithelia for endogenous S. aureus-killing factors...
  49. pmc The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
    H Ceri
    Biofilm Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Clin Microbiol 37:1771-6. 1999
    ..Standards (NCCLS) reference strains: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 29213...
  50. pmc The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country
    Alex J McCarthy
    Centre for Infection, Department of Clinical Sciences, St George s University of London, United Kingdom
    Genome Biol Evol 3:1164-74. 2011
    Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S...
  51. pmc Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spre
    Stephen Murchan
    Laboratory of Hospital Infection, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 41:1574-85. 2003
    ..most common genotypic method used in reference and clinical laboratories for typing methicillin-resistant Staphylococcus aureus (MRSA)...
  52. pmc Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus
    Catarina Milheiriço
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Antimicrob Agents Chemother 51:3374-7. 2007
    ..chromosome mec (SCCmec) typing is important for the identification and definition of methicillin-resistant Staphylococcus aureus clones, and for routine purposes, multiplex PCR assays are the most adequate for SCCmec typing...
  53. pmc Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism
    Chantal Bohn
    Institut de Genetique et Microbiologie, CNRS UMR 8621, IFR115, Centre Scientifique d Orsay, Universite Paris Sud, Batiment 400, 91405 Orsay Cedex, France
    Nucleic Acids Res 38:6620-36. 2010
    Using an experimental approach, we investigated the RNome of the pathogen Staphylococcus aureus to identify 30 small RNAs (sRNAs) including 14 that are newly confirmed...
  54. doi The emergence of Staphylococcus aureus ST398
    Tara C Smith
    Department of Epidemiology, Center for Emerging Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    Vector Borne Zoonotic Dis 11:327-39. 2011
    The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) has changed dramatically over the past 15 years...
  55. ncbi A common mechanism of cellular death induced by bactericidal antibiotics
    Michael A Kohanski
    Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 130:797-810. 2007
    ..g., reca...
  56. ncbi Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
    As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed.
  57. pmc Antibiotics for emerging pathogens
    Michael A Fischbach
    Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 325:1089-93. 2009
    ....
  58. ncbi Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
    J Immunol 165:5392-6. 2000
    ..TLR family in host defense against Gram-positive bacteria, we infected TLR2- and MyD88-deficient mice with Staphylococcus aureus. Both TLR2- and MyD88-deficient mice were highly susceptible to S...
  59. ncbi Vancomycin resistance in gram-positive cocci
    Patrice Courvalin
    Unite des Agents Antibacteriens, Institut Pasteur, Paris, France
    Clin Infect Dis 42:S25-34. 2006
    ..The diversity, regulation, evolution, and recent dissemination of methicillin-resistant Staphylococcus aureus are then discussed.
  60. pmc The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages
    Willem J B Van Wamel
    Eijkman Winkler Institute, Room G04 614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Bacteriol 188:1310-5. 2006
    Two newly discovered immune modulators, chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) and staphylococcal complement inhibitor (SCIN), cluster on the conserved 3' end of beta-hemolysin (hlb)-converting bacteriophages (..
  61. pmc Complement evasion by human pathogens
    John D Lambris
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Microbiol 6:132-42. 2008
    ..Recent discoveries in this field have provided important insights into these processes on a molecular level. These vital developments could augment our knowledge of the pathology and treatment of infectious and inflammatory diseases...
  62. pmc The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus
    Kelly C Rice
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 104:8113-8. 2007
    The Staphylococcus aureus cidA and lrgA genes have been shown to affect cell lysis under a variety of conditions during planktonic growth...
  63. pmc Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
    Anne Laure Genestier
    Centre National de Référence des Staphylocoques, INSERM E0230, Lyon, France
    J Clin Invest 115:3117-27. 2005
    Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by Staphylococcus aureus that has recently been associated with necrotizing pneumonia...
  64. doi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    Recent studies have suggested that community-associated methicillin-resistant Staphylococcus aureus (MRSA) infection is encroaching on health care settings...
  65. ncbi Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nat Med 13:1510-4. 2007
    Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen...
  66. pmc Staphylococcus aureus biofilms: properties, regulation, and roles in human disease
    Nathan K Archer
    Department of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, MD, USA
    Virulence 2:445-59. 2011
    ..components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with ..
  67. doi Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus
    Takehisa Ohbayashi
    Department of Oral and Maxillo Facial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Microbiology 157:786-92. 2011
    b>Staphylococcus aureus is the most frequently isolated pathogen in gram-positive sepsis often complicated by a blood clotting disorder, and is the leading cause of infective endocarditis induced by bacterial destruction of endocardial ..
  68. pmc Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex
    Christelle M Roux
    Department of Microbiology and Immunology, University of Rochester Medical Center, School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bacteriol 193:5520-6. 2011
    Bacterial two-hybrid analysis identified the Staphylococcus aureus RNA degradosome-like complex to include RNase J1, RNase J2, RNase Y, polynucleotide phosphorylase (PNPase), enolase, phosphofructokinase, and a DEAD box RNA helicase...
  69. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA.
  70. pmc Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
    Michael M Mwangi
    Physics Department, Cornell University, Ithaca, NY 14850, USA
    Proc Natl Acad Sci U S A 104:9451-6. 2007
    The spread of multidrug-resistant Staphylococcus aureus (MRSA) strains in the clinical environment has begun to pose serious limits to treatment options. Yet virtually nothing is known about how resistance traits are acquired in vivo...
  71. pmc Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community
    Keiko Okuma
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    J Clin Microbiol 40:4289-94. 2002
    Multiple methicillin-resistant Staphylococcus aureus (MRSA) clones carrying type IV staphylococcal cassette chromosome mec were identified in the community-acquired MRSA strains of both the United States and Australia...
  72. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
    We conducted a study among a group of 26 regional pig farmers to determine the methicillin-resistant Staphylococcus aureus prevalence rate and found it was >760 times greater than the rate of patients admitted to Dutch hospitals...
  73. pmc Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease
    Bernadette C Young
    Experimental Medicine Division, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 109:4550-5. 2012
    ..b>Staphylococcus aureus is a major cause of bacteria-associated mortality and invasive disease and is carried asymptomatically by ..
  74. pmc The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages
    Tony Kwan
    Targanta Therapeutics, 7170 Frederick Banting, Second Floor, Ville Saint Laurent, QC, Canada H4S 2A1
    Proc Natl Acad Sci U S A 102:5174-9. 2005
    ..the complete genomic sequences, and predicted proteins of 27 bacteriophages of the Gram-positive bacterium Staphylococcus aureus. Comparative nucleotide and protein sequence analysis indicates that these phages are a remarkable source ..
  75. ncbi Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
    Catarina Milheiriço
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Antimicrob Chemother 60:42-8. 2007
    To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR.
  76. pmc D-amino acids trigger biofilm disassembly
    Ilana Kolodkin-Gal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 328:627-9. 2010
    ..D-amino acids also prevented biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa...
  77. ncbi Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
    G Lina
    Centre National de Référence de Toxémies Staphylococciques, Faculte de Medecine, 69372 Lyon Cedex 08, France
    Clin Infect Dis 29:1128-32. 1999
    ..It is produced by fewer than 5% of Staphylococcus aureus strains. A collection of 172 S...
  78. doi Peptidoglycan architecture can specify division planes in Staphylococcus aureus
    Robert D Turner
    Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Nat Commun 1:26. 2010
    ..microscopy with vancomycin labelling to examine purified peptidoglycan architecture and its dynamics in Staphylococcus aureus and correlate these with the cell cycle...
  79. pmc Protein A-mediated multicellular behavior in Staphylococcus aureus
    Nekane Merino
    Instituto de Agrobiotecnologia, Universidad Publica de Navarra, Pamplona 31006, Spain
    J Bacteriol 191:832-43. 2009
    The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S...
  80. pmc Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development
    Allon I Hochbaum
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 1903, USA
    J Bacteriol 193:5616-22. 2011
    ..D-amino acids also prevent biofilm formation by the related Gram-positive bacterium Staphylococcus aureus. Here we employed fluorescence microscopy and confocal laser scanning microscopy to investigate how D-..
  81. pmc A very early-branching Staphylococcus aureus lineage lacking the carotenoid pigment staphyloxanthin
    Deborah C Holt
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Genome Biol Evol 3:881-95. 2011
    Here we discuss the evolution of the northern Australian Staphylococcus aureus isolate MSHR1132 genome. MSHR1132 belongs to the divergent clonal complex 75 lineage...
  82. pmc Staphylococcus epidermidis Esp degrades specific proteins associated with Staphylococcus aureus biofilm formation and host-pathogen interaction
    Shinya Sugimoto
    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, Japan
    J Bacteriol 195:1645-55. 2013
    b>Staphylococcus aureus exhibits a strong capacity to attach to abiotic or biotic surfaces and form biofilms, which lead to chronic infections...
  83. pmc Genome-wide antisense transcription drives mRNA processing in bacteria
    Iñigo Lasa
    Laboratory of Microbial Biofilms, Instituto de Agrobiotecnologia, Consejo Superior de Investigaciones Científicas Universidad Pública de Navarra Gobierno de Navarra, 31006 Pamplona, Spain
    Proc Natl Acad Sci U S A 108:20172-7. 2011
    ..to both the long and short RNA fractions (<50 nucleotides) obtained from the major human pathogen Staphylococcus aureus, we have detected a collection of short RNAs that is generated genome-wide through the digestion of ..
  84. ncbi Treatment of infections associated with surgical implants
    Rabih O Darouiche
    Center for Prostheses Infection and the Infectious Disease Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 350:1422-9. 2004
  85. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..genetic screen, we identify the Drosophila melanogaster scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria...
  86. pmc Molecular correlates of host specialization in Staphylococcus aureus
    Lisa Herron-Olson
    Department of Microbiology, Veterinary Pathobiology and Biomedical Genomics Center, University of Minnesota, Saint Paul, Minnesota, United States of America
    PLoS ONE 2:e1120. 2007
    The majority of Staphylococcus aureus isolates that are recovered from either serious infections in humans or from mastitis in cattle represent genetically distinct sets of clonal groups...
  87. pmc Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation
    Blaise R Boles
    Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e10146. 2010
    b>Staphylococcus aureus is a potent biofilm former on host tissue and medical implants, and biofilm growth is a critical virulence determinant for chronic infections...
  88. ncbi Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
    T Khanna
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Vet Microbiol 128:298-303. 2008
    Methicillin resistant Staphylococcus aureus (MRSA) colonization has recently been identified in pigs and people that work with pigs, raising concerns about the role of pigs as reservoirs of MRSA for human infection...
  89. doi Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?
    Raymond Ruimy
    EA3964 Université Paris Diderot and Centre National de Référence, Résistance bactérienne dans les flores commensales, Hopital Bichat Claude Bernard, AP HP, Paris, France
    J Infect Dis 202:924-34. 2010
    b>Staphylococcus aureus nasal carriage is influenced by multifactorial interactions which are difficult to study in open populations...
  90. ncbi Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    J D Pollock
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    Nat Genet 9:202-9. 1995
    ..male mice lacked phagocyte superoxide production, manifested an increased susceptibility to infection with Staphylococcus aureus and Aspergillus fumigatus and had an altered inflammatory response in thioglycollate peritonitis...
  91. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids...
  92. ncbi Staphylococcus aureus: Staphylokinase
    Maria I Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, SE 41346 Göteborg, Sweden
    Int J Biochem Cell Biol 38:504-9. 2006
    Staphylokinase is a 136 aa long bacteriophage encoded protein expressed by lysogenic strains of Staphylococcus aureus. Present understanding of the role of staphylokinase during bacterial infection is based on its interaction with the ..
  93. pmc New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus
    Sarah Dubrac
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, CNRS URA 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Bacteriol 189:8257-69. 2007
    ..We observed that, unexpectedly, Staphylococcus aureus cell death induced by WalKR depletion was not followed by lysis...
  94. ncbi Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    K Hiramatsu
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Lancet 350:1670-3. 1997
    Since the discovery of the vancomycin-resistant Staphylococcus aureus (VRSA) strain Mu50 (minimum inhibitory concentration [MIC] 8 mg/L), there has been concern about the potential spread of such strains throughout Japanese hospitals...
  95. pmc Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
    Sarah K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    BMC Microbiol 7:99. 2007
    Community acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) increasingly causes disease worldwide. USA300 has emerged as the predominant clone causing superficial and invasive infections in children and adults in the USA...
  96. pmc Characterization of the accessory Sec system of Staphylococcus aureus
    Ian R Siboo
    Division of Infectious Diseases, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    J Bacteriol 190:6188-96. 2008
    The SraP adhesin of Staphylococcus aureus is a member of a highly conserved family of serine-rich surface glycoproteins of gram-positive bacteria...
  97. pmc A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation
    Thomas Geissmann
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Nucleic Acids Res 37:7239-57. 2009
    Bioinformatic analysis of the intergenic regions of Staphylococcus aureus predicted multiple regulatory regions. From this analysis, we characterized 11 novel noncoding RNAs (RsaA-K) that are expressed in several S...
  98. doi The relationship between the nanostructure of titanium surfaces and bacterial attachment
    Sabrina D Puckett
    Division of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02917, USA
    Biomaterials 31:706-13. 2010
    ..This study examined the adhesion of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa on conventional Ti, nanorough Ti produced by ..
  99. pmc Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study
    David R Murdoch
    Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand
    Arch Intern Med 169:463-73. 2009
    ..We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide...
  100. pmc Metabolite-enabled eradication of bacterial persisters by aminoglycosides
    Kyle R Allison
    Howard Hughes Medical Institute, Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, Massachusetts 02215, USA
    Nature 473:216-20. 2011
    ..specific metabolic stimuli enable the killing of both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) persisters with aminoglycosides...
  101. doi A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus
    Florian H Pilsczek
    Snyder Institute of Infection, Immunity and Inflammation, Hiroshima University, Hiroshima, Japan
    J Immunol 185:7413-25. 2010
    ..In this study, we describe neutrophils responding uniquely to Staphylococcus aureus via a novel process of NET formation that did not require neutrophil lysis or even breach of the plasma ..

Research Grants76

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..environment : Sterilizes contaminated wounds of drug- resistant super bugs like Methicillin-Resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes and Pseudomonas aeruginosa...
  2. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Serious infection with Staphylococcus aureus (SA) remains an important clinical challenge despite potent antibiotics...
  3. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..vaccine to prevent invasive, life- threatening infections by the medically important bacterial pathogen Staphylococcus aureus. Because S...
  4. Non-invasive zoonotic pathogen exposure and outcome biomarkers with follow-up in
    Christopher D Heaney; Fiscal Year: 2013
    ..training in multi-locus sequence typing (MLST) and whole genome SNP analysis (WGSA) of multidrug-resistant Staphylococcus aureus (MDRSA) isolated from nasal swabs of livestock workers and household members in an ongoing cross-sectional ..
  5. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..Research Plan A recent report has documented the clinical impact of methicillin-resistant Staphylococcus aureus (MRSA), suggesting that MRSA caused over 94,000 invasive infections and more than 18,000 deaths in the ..
  6. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..that electrical currents of 20 to 2000 <A substantially reduced established Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms, a phenomenon we termed the "electricidal effect" (Antimicrob Ag ..
  7. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..of non-vaccine serotypes of Streptococcus pneumioniae and highly virulent clones of methcillin resistant Staphylococcus aureus (MRSA)...
  8. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..against a wide variety of multi-resistant Gram-negative bacilli and also against Methicillin-Resistant Staphylococcus aureus (MRSA)...
  9. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..Myx exhibits potent antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and Clostridium difficile in ..
  10. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..and transplant recipients with rejection and idiopathic lung diseases;2) detection of specific pathogens (Staphylococcus aureus, nosocomial multidrug resistant gram negative rods, influenza virus), their virulence determinants and ..
  11. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    A CDC/APIC sponsored study revealed in June 2007 a pressing health crisis for the United States: Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections...
  12. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..on two of the most prevalent etiologic agents of catheter-related and surgical site infections, namely Staphylococcus aureus and Enterococcus faecalis...
  13. Inhibitors of S. aureus bNOS for adjunctive therapy
    Donald T Moir; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Staphylococcus aureus is a major cause of community and hospital-acquired infections of the skin, soft tissue, and bloodstream...
  14. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2009
    ..are extant in several select human pathogens, for example, (FosA) in Pseudomonas aeruginosa, (FosB) in Staphylococcus aureus and Bacillus anthracis, and (FosX) in Brucella melitensis, Listeria monocytogenes and Clostridium ..
  15. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..for long-awaited antibiotic development against dangerous gram-positive strains of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE)...
  16. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..g., Trypanosoma brucei, African sleeping sickness) and pathogenic bacteria (e.g., Staphylococcus aureus) adapt and survive, mitochondrial energetic processes, connective tissue and skin disorders, and ..
  17. Structural mechanism of DNA segregation by the pSK41 par system
    Maria Schumacher; Fiscal Year: 2010
    ..This proposal focuses on one such par system from Staphylococcus aureus multi-drug resistance plasmid pSK41...
  18. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..aeruginosa, Haemophilus influenzae) and Gram-positive (Staphylococcus aureus) organisms and in two genetic backgrounds (C57BL/6 and129S6)...
  19. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..agents exhibit broad-spectrum activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus pyogenes (Group A strep), ..
  20. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..has uncovered SLS-like toxins are synthesized by at least three other notorious human pathogens, including Staphylococcus aureus, Listeria monocytogenes, and Clostridium botulinum...
  21. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..regulator that we discovered in the spore-forming bacterium, Bacillus subtilis, but is also found in Staphylococcus aureus, Streptococcus pneumoniae, Listeria monocytogenes, and Bacillus anthracis...
  22. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..A) is an essential protein present in Gram-positive bacteria, including important human pathogens such as Staphylococcus aureus, Streptococcus pneumonia, Clostridium perfringens, Listeria monocytogenes, Bacillus anthracis, etc...
  23. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..Although Staphylococcus aureus is by far the most virulent of species, Staphylococcus epidermidis and Staphylococcus lugdunensis have ..
  24. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..events associated with lactoferrin mediation will also be investigated using methicillin-resistant Staphylococcus aureus bacteria (MRSA) infection, which is troublesome in hospital-associated (nosocomial) infections...
  25. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    ..been shown to be important regulators of cell death, autolysis and biofilm development in the pathogen Staphylococcus aureus. The specific aims of this application are (1) to ascertain the role of the cid and lrg genes in ..
  26. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..b>Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections in the world...
  27. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..Separate detection and quantification of eight genetic markers (species-specific for Staphylococcus aureus, S. epidermidis, Enterococcus faecalis, E...
  28. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    ADIL YOUSIF SHAMOO; Fiscal Year: 2012
    ..Data from 2004 show that despite the best efforts of the medical community, methicillin resisistant Staphylococcus aureus (MRSA) were found in over 60% and vancomycin resistant Enterococci (VRE) in nearly 30% of ICU patients ..
  29. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..in Phase I that we can suppress biofilm formation and planktonic growth of Pseudomonas aeruginosa and Staphylococcus aureus for an extended period of time...
  30. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..understanding the epidemiology of resistance in Gram-positive organisms, especially methicillin-resistant Staphylococcus aureus, much less is known about the epidemiology of multi-drug resistance in Gram-negative organisms, ..
  31. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi and Clostridium tetani...
  32. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    ..Pneumonias resulting from failure to eradicate bacterial (Streptococcus pneumonia, Haemophilus influenza, Staphylococcus aureus, Pseudomonas aeruginosa) and viral (rhinovirus, influenza virus) infections are responsible for a ..
  33. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..All experiments will be carried out using the common wound pathogen Staphylococcus aureus. Topical biocides will include povidone iodine and chlorhexidine gluconate...
  34. Structure and Mechanism of SAM-responsive Riboswitches
    Robert T Batey; Fiscal Year: 2013
    ..under riboswitch control in a number of medically important pathogens including Listeria monocytogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis making them of great interest as novel targets for ..
  35. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..testing (AIM 3) will be growth inhibition of both ATCC and clinical strains of multiple drug resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae...
  36. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..The initial focus will be on pathogens such as Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, however the approach has general applicability...
  37. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Role of Staphylococcus aureus alpha-hemolysin in disease Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections in the United States...
  38. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..is to gain insight into mechanisms of cutaneous host defense against the common bacterial skin pathogen Staphylococcus aureus. S...
  39. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Staphylococcus aureus is a ubiquitous Gram-positive organism implicated in a spectrum of diseases;from benign, localized skin infections to life-threatening, systemic illnesses including pneumonia, ..
  40. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF
    Taneli Jouhikainen; Fiscal Year: 2012
    ..a novel inhaled dry-powder form of vancomycin (AEROVANC) for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection, initially in cystic fibrosis (CF) patients and subsequently in other high risk patient ..
  41. Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    ROBERT ALAN SHALWITZ; Fiscal Year: 2013
    ..boost HIF-1 in human phagocytes and cause them to kill pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable to classical antibiotic therapy...
  42. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..Specifically, this application will focus on infections caused by Pseudomonas aeruginosa and Staphylococcus aureus. These two pathogens are among the most common causes of serious corneal infections...
  43. Chemistry, Structure and Biology of Thiol Transferases
    Richard N Armstrong; Fiscal Year: 2013
    ..and purified the FosB enzymes from several sources including Bacillus cereus, Bacillus anthracis and Staphylococcus aureus which puts us in an excellent position to accomplish this aim...
  44. Biomarker Screening of Essential Putative Glycoprotease Inhibitor
    Yinduo Ji; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Given the well-known pathogenicity of Staphylococcus aureus, the emergence of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S...
  45. Proteomics of RNA polymerase interactomes in pathogenic bacteria
    Evgeny Nudler; Fiscal Year: 2013
    ..transient interactions of the central enzyme of gene expression, RNA polymerase, in pathogenic bacteria Staphylococcus aureus and Bacillus anthracis, as well as the topology and composition of the more stable macromolecular ..
  46. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..The first includes E. coli O157, O104 and Shigella sonnei;the second includes Staphylococcus aureus. Aim 2: Production of PS-protein variants Our bacterial protein N-glycosylation platform allow us to ..
  47. Mechanisms and regulation of serine resolvases
    Phoebe A Rice; Fiscal Year: 2012
    ..reaction that is important for stable maintenance of many drug resistance-carrying plasmids found in Staphylococcus aureus, a common cause of opportunistic infections...
  48. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas aeruginosa...
  49. Superantigen-Induced Vascular Injury and DIC
    JACK J HAWIGER; Fiscal Year: 2011
    ..Community- acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) is responsible for Acute Lung Injury (ALI) associated with necrotizing pneumonia often ..
  50. Inhibition of lung defense by air pollutant particulates
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..and then infected with airway pathogens that cause pneumonia, such as Streptococcus zooepidemicus and Staphylococcus aureus. This research will help determine the mechanism and levels of inhaled vanadium necessary to suppress the ..
  51. Protein Structure/Function by NMR, Crystallography and Computational Chemistry
    Eric Oldfield; Fiscal Year: 2012
    ..to develop molecules that inhibit formation of the orange carotenoid virulence factor, staphyloxanthin, in Staphylococcus aureus. In recent work, we discovered that human squalene synthase inhibitors can also block staphyloxanthin ..
  52. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..including Candida albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae...
  53. Synergy between TLR2 and IL-22R in airway epithelial cells during MRSA challenge
    Jeremy P McAleer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The gram-positive organism Staphylococcus aureus colonizes the nasal passages in 20-50 percent of people, and community-acquired pneumonia caused by methicillin-resistant S...
  54. REGULATION OF LIPID METABOLISM IN BACTERIA
    Charles O Rock; Fiscal Year: 2013
    ..the research plan on investigating fatty acid and phospholipid synthesis in two important human pathogens: Staphylococcus aureus and Streptococcus pneumoniae...
  55. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recently methicillin resistant Staphylococcus aureus (MRSA) has surpased HIV as the most deadly pathogen in the United States, accounting for over 100,000 deaths per year...
  56. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ..of antibiotic resistant Pseudomonas aerugenosa, Hemophilus influenza, Streptococcus pneumoniae and Staphylococcus aureus biofilms in the sinuses of cure resistant CRS...
  57. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..The human and financial impact of Methicillin-resistant Staphylococcus aureus (MRSA) is high. MRSA now accounts for greater than 60% of hospital-acquired S...
  58. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Staphylococcus aureus infections of the bloodstream, lung, surgical sites, and skin and soft tissues are a leading cause of morbidity and mortality...
  59. Multi-specific Antibody Therapy by targeting S. aureus toxins and polysaccharides
    M Javad Aman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Staphylococcus aureus is a human pathogen that causes a wide range of diseases from skin and soft tissue infections (SSTI) to life threatening sepsis and pneumonia. Infections with S...
  60. S. aureus and Regulatory T cells in the Failure of Oral Tolerance
    Anne Marie Singh; Fiscal Year: 2013
    ..Exciting new preliminary data demonstrate increased Staphylococcus aureus burden in the gut of patients with food allergy, and previous work has also illustrated increased IL-10 ..
  61. Preventing Burn Wound Infection Using a Novel Free Radical Sterilization System
    BENJAMIN DAVID SADOWITZ; Fiscal Year: 2011
    ..model of deep dermal partial thickness burn injury to create a polymicrobial burn wound infection with Staphylococcus aureus and Pseudomonas aeruginosa, two of the common organisms causing burn wound infection in humans...
  62. Prevalance of Community-Acquired MRSA in Live Pigs and thier Human Handlers
    LYNDA UJU ODOFIN; Fiscal Year: 2010
    ..growing evidence that livestock may be involved in spread of community-associated Methicillin Resistant Staphylococcus aureus (CA-MRSA);recent studies from Europe and Canada report a new strain (ST 398) that maybe associated with ..
  63. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..This lead compound cannot kill Staphylococcus aureus, Streptococcus pneumoniae, Helicobacter pylori or Haemophilus ducreyi, among other strains, in vitro...
  64. Selenium Coated Dialysis Catheters for Reduced Biofilm Formation
    Eric Tobin; Fiscal Year: 2009
    ..I successfully demonstrated significant (>90%) reduction in biofilm formation for both gram positive (Staphylococcus aureus) and gram negative (Pseudomonas aeruginosa) bacteria on selenium coated polyurethane catheter material...
  65. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..new inhibitors of PG synthesis are needed for eubacteria in general, such a methicillin resistant Staphylococcus aureus and bioterrorist agents including Burkholderia pseudomallei and Yersinia pestis...
  66. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..provided by applicant): Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains in healthy individuals have raised concerns worldwide...
  67. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Staphylococcus aureus is an opportunistic bacterial pathogen responsible for a diverse spectrum of human and animal diseases, including wound infections, osteomyelitis, endocarditis, and ..
  68. ELECTRON TRANSPORT VARIANTS IN STAPHYLOCOCCAL DISEASE
    Richard Proctor; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Staphylococcus aureus causes persistent and recurrent infections, even when highly active antibiotics are used. Dr...
  69. STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY
    Jean Lee; Fiscal Year: 1993
    b>Staphylococcus aureus is a bacterial pathogen responsible for a diverse spectrum of human and animal diseases. Most S. aureus isolates are microencapsulated, i.e...
  70. Structure and Cell-Wall Targeting of the Staphylolytic Enzyme Lysostaphin
    KEITH GRISCOM INMAN; Fiscal Year: 2010
    A major impediment to successful treatment of Staphylococcus aureus is its tendency to develop antibiotic resistance...
  71. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
    ..research is to identify the components and their interrelationships controlling methicillin resistance in Staphylococcus aureus. Methicillin resistant strains of staphylococci produced a novel 78kd penicillin-binding protein (PBP), ..
  72. Statewide Implementation of Guidelines to Control MRSA
    Loreen Herwaldt; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Methicillin (oxacillin)-resistant Staphylococcus aureus (MRSA) is by far the most common resistant bacterial pathogen...
  73. REGULATION OF BETA-LACTAMASE IN STAPHYLOCOCCUS AUREUS
    Corinne Hackbarth; Fiscal Year: 2000
    ..protein 2a (PBP2a), which are responsible for resistance to the beta-lactam class of antibiotics in Staphylococcus aureus. S. aureus is a common cause of nosocomial as well as community-acquired infections in the United States...
  74. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    b>Staphylococcus aureus is a major human pathogen. It can cause rapidly fatal infections. A highly virulent clone of methicillin resistant S. aureus (MRSA), USA300, is epidemic in communities in the United States...
  75. SITE SPECIFIC RECOMBINATION IN STAPHYLOCOCCUS AUREUS
    Ellen Murphy; Fiscal Year: 1990
    Tn554 is a transposable element in Staphylococcus aureus that encodes resistances to spectinomycin and to the macrolide-lincosamide-streptogramin B antibiotics. Tn554 inserts efficiently into a unique site in the S. aureus chromosome...
  76. Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
    Cynthia Stauffacher; Fiscal Year: 2007
    ..that a number of common human pathogens, including Enterococcus faecalis, Streptococcus pneumoniae and Staphylococcus aureus are dependent on enzymes in the mevalonate pathway for biosynthesis of IPP, including the central pathway ..