haemophilus influenzae type b

Summary

Summary: A type of H. influenzae isolated most frequently from biotype I. Prior to vaccine availability, it was a leading cause of childhood meningitis.

Top Publications

  1. ncbi Global status of Haemophilus influenzae type b and pneumococcal conjugate vaccines: evidence, policies, and introductions
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, International Vaccine Access Center, Baltimore, Maryland, USA
    Curr Opin Infect Dis 23:236-41. 2010
  2. pmc The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Int J Epidemiol 39:i172-85. 2010
  3. pmc Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan
    Bjorn Vergauwen
    Laboratory of Protein Biochemistry and Protein Engineering, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    BMC Microbiol 6:3. 2006
  4. ncbi Transplacental transport of IgG antibodies specific for pertussis, diphtheria, tetanus, haemophilus influenzae type b, and Neisseria meningitidis serogroup C is lower in preterm compared with term infants
    Jolice P van den Berg
    Department of Paediatrics, Division of Neonatology, VU University Medical Center, Amsterdam
    Pediatr Infect Dis J 29:801-5. 2010
  5. pmc Incidence of bacterial meningitis in Asia using enhanced CSF testing: polymerase chain reaction, latex agglutination and culture
    W A Kennedy
    Department of Paediatrics, UCLA School of Medicine and the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, USA
    Epidemiol Infect 135:1217-26. 2007
  6. ncbi Concentration and avidity of anti-Haemophilus influenzae type b (Hib) antibodies in serum samples obtained from patients for whom Hib vaccination failed
    Mijke A Breukels
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center, 3584 EA, Utrecht, The Netherlands
    Clin Infect Dis 34:191-7. 2002
  7. ncbi The influence of maternal immunization on light chain response to Haemophilus influenzae type b vaccine
    Moon H Nahm
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Vaccine 21:3393-7. 2003
  8. ncbi Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: evolving principles in diagnosis and management
    Elizabeth Guardiani
    Georgetown University Hospital, Department of Otolaryngology Head and Neck Surgery, Washington, DC, USA
    Laryngoscope 120:2183-8. 2010
  9. ncbi Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries
    Sean P Fitzwater
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hum Vaccin 6:810-8. 2010
  10. pmc Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom
    J McVernon
    Population Biology of Infectious Disease Group, Department of Zoology, University of Oxford, UK
    Epidemiol Infect 136:800-12. 2008

Detail Information

Publications229 found, 100 shown here

  1. ncbi Global status of Haemophilus influenzae type b and pneumococcal conjugate vaccines: evidence, policies, and introductions
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, International Vaccine Access Center, Baltimore, Maryland, USA
    Curr Opin Infect Dis 23:236-41. 2010
    The leading causes of bacterial meningitis and pneumonia in children, Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae, are vaccine preventable...
  2. pmc The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Int J Epidemiol 39:i172-85. 2010
    ..of existing interventions, we conducted a systematic review of the literature assessing the effect of Haemophilus influenzae type b (Hib) and pneumococcal (PC) conjugate vaccines on incidence, severe morbidity and mortality from ..
  3. pmc Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan
    Bjorn Vergauwen
    Laboratory of Protein Biochemistry and Protein Engineering, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    BMC Microbiol 6:3. 2006
    ..However, Haemophilus influenzae type b strain Eagan (Hib), a causative agent of bacterial sepsis and meningitis in young children, disrupted ..
  4. ncbi Transplacental transport of IgG antibodies specific for pertussis, diphtheria, tetanus, haemophilus influenzae type b, and Neisseria meningitidis serogroup C is lower in preterm compared with term infants
    Jolice P van den Berg
    Department of Paediatrics, Division of Neonatology, VU University Medical Center, Amsterdam
    Pediatr Infect Dis J 29:801-5. 2010
    ....
  5. pmc Incidence of bacterial meningitis in Asia using enhanced CSF testing: polymerase chain reaction, latex agglutination and culture
    W A Kennedy
    Department of Paediatrics, UCLA School of Medicine and the Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, USA
    Epidemiol Infect 135:1217-26. 2007
    ..latex agglutination (LA) and polymerase chain reaction-enzyme immunoassay (PCR-EIA) testing for Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (Sp)...
  6. ncbi Concentration and avidity of anti-Haemophilus influenzae type b (Hib) antibodies in serum samples obtained from patients for whom Hib vaccination failed
    Mijke A Breukels
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center, 3584 EA, Utrecht, The Netherlands
    Clin Infect Dis 34:191-7. 2002
    b>Haemophilus influenzae type b (Hib) conjugate vaccines are extremely effective in protecting infants and children from invasive Hib infections; however, vaccine failures do occur...
  7. ncbi The influence of maternal immunization on light chain response to Haemophilus influenzae type b vaccine
    Moon H Nahm
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Vaccine 21:3393-7. 2003
    The repertoire of human antibodies to Haemophilus influenzae type b polysaccharide (Hib PS) has been extensively characterized. In response to Hib PS vaccines, both IgG1 and IgG2 antibodies are produced...
  8. ncbi Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: evolving principles in diagnosis and management
    Elizabeth Guardiani
    Georgetown University Hospital, Department of Otolaryngology Head and Neck Surgery, Washington, DC, USA
    Laryngoscope 120:2183-8. 2010
    To review the demographics, presentation, interventions, and outcomes of acute supraglottitis in the post-Haemophilus influenzae type B (Hib) vaccination era and make updated recommendations for treatment.
  9. ncbi Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries
    Sean P Fitzwater
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hum Vaccin 6:810-8. 2010
    Prior to widespread vaccination, Haemophilus influenzae type b was a leading cause of severe childhood bacterial infection, including meningitis, worldwide...
  10. pmc Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom
    J McVernon
    Population Biology of Infectious Disease Group, Department of Zoology, University of Oxford, UK
    Epidemiol Infect 136:800-12. 2008
    A rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated...
  11. pmc Immunologic memory in Haemophilus influenzae type b conjugate vaccine failure
    J McVernon
    Oxford Vaccine Group, University of Oxford Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Arch Dis Child 88:379-83. 2003
    To compare the convalescent antibody response to invasive Haemophilus influenzae type b (Hib) disease between conjugate vaccine immunised and unimmunised children, to look for evidence of priming for immunologic memory.
  12. ncbi Introduction of Haemophilus influenzae type B conjugate vaccine into routine immunization in Ghana and its impact on bacterial meningitis in children younger than five years
    Lorna Awo Renner
    Department of Child Health, University of Ghana Medical School, Accra, Ghana
    Pediatr Infect Dis J 26:356-8. 2007
    This report shows the impact of a pentavalent vaccine that includes Haemophilus influenzae type b (Hib) conjugate vaccine on bacterial meningitis in children younger than 5 years in Ghana...
  13. pmc Cost-benefit analysis of haemophilus influenzae type B immunization in Korea
    Sangjin Shin
    Department of Health Care Management and Policy, Seoul National University, School of Public Health, Seoul, Korea
    J Korean Med Sci 23:176-84. 2008
    An economic evaluation of Haemophilus influenzae type b (Hib) immunization was conducted to examine whether Hib immunization should be included in Korea's national immunization program...
  14. pmc Accelerating policy decisions to adopt haemophilus influenzae type B vaccine: a global, multivariable analysis
    Jessica C Shearer
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    PLoS Med 7:e1000249. 2010
    ..Using the case of Haemophilus influenzae type b (Hib) vaccine, this paper endeavors to explain these delays through the analysis of country-level ..
  15. ncbi Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunization
    D Goldblatt
    Institute of Child Health, and Immunisation Division, Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 177:1112-5. 1998
    ..of relatively high-avidity antibody; thus, a solid-phase ELISA was adapted for the measurement of anti-Haemophilus influenzae type b (Hib) IgG avidity...
  16. pmc Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates
    H Peltola
    Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
    Clin Microbiol Rev 13:302-17. 2000
    Vaccination against Haemophilus influenzae type b (Hib) diseases began a quarter of a century ago with a polysaccharide vaccine; this vaccine was followed by four different conjugates 10 years later...
  17. ncbi Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era
    P T Heath
    Oxford Vaccine Group, UK
    Pediatr Infect Dis J 20:300-5. 2001
    BACKGROUND: As a result of the decline in Haemophilus influenzae type b (Hib) disease caused by the widespread use of conjugate vaccines, non-type b H. influenzae will become a more important cause of H. influenzae (Hi) disease...
  18. pmc Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing
    Emma Meats
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, London W2 1PG, United Kingdom
    J Clin Microbiol 41:1623-36. 2003
    ..The H. influenzae MLST scheme is available at www.mlst.net, it allows any isolate to be compared with those in the MLST database, and (for encapsulated isolates) it assigns isolates to their phylogenetic lineage, via the Internet...
  19. ncbi A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine is immunogenic and induces immune memory when co-administered with DTPa-HBV-IPV and conjugate pneumococcal vaccines in infants
    Terry Nolan
    Murdoch Children s Research Institute and School of Population Health, The University of Melbourne, Australia
    Vaccine 25:8487-99. 2007
    Immunogenicity and safety of a novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine (Hib-MenCY-TT) candidate was evaluated when co-administered with DTPa-HBV-IPV(Pediarix)..
  20. ncbi Haemophilus influenzae type b disease in HIV-infected children: a review of the disease epidemiology and effectiveness of Hib conjugate vaccines
    Punam Mangtani
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Vaccine 28:1677-83. 2010
    ..However, HIV-infected children have an almost 6-fold higher risk of Haemophilus influenzae type b (Hib) invasive disease than HIV-uninfected children and HibCV effectiveness is lower in this ..
  21. pmc Rapid assessment tool for Haemophilus influenzae type b disease in developing countries
    Daniel R Feikin
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 10:1270-6. 2004
    b>Haemophilus influenzae type b (Hib) still causes a substantial number of deaths among children in developing countries, despite the availability of effective conjugate vaccines...
  22. ncbi Childhood bacterial meningitis in Ulaanbaatar, Mongolia, 2002-2004
    Jamsran Mendsaikhan
    World Health Organization, Mongolia Office, Ulaanbaatar, Mongolia
    Clin Infect Dis 48:S141-6. 2009
    ..Few data on childhood bacterial meningitis in Northeast and Central Asia exist. Our aim was to determine the incidence and etiology of childhood bacterial meningitis in Ulaanbaatar, Mongolia...
  23. ncbi Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009
    Anne Von Gottberg
    National Institute for Communicable Diseases NICD of the National Health Laboratory Service NHLS, Johannesburg, South Africa
    Vaccine 30:565-71. 2012
    ..Following initial declines in Hib disease, national surveillance has identified increasing numbers of Hib disease episodes in fully vaccinated children...
  24. ncbi Evaluation of polymerase chain reaction (PCR) for diagnosing Haemophilus influenzae b meningitis
    Sunit C Singhi
    Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Ann Trop Paediatr 22:347-53. 2002
    ..We conclude that PCR is a sensitive and specific diagnostic tool that may be valuable in a population with high pre-hospital antibiotic usage...
  25. ncbi Response of MUTZ-3 dendritic cells to the different components of the Haemophilus influenzae type B conjugate vaccine: towards an in vitro assay for vaccine immunogenicity
    Marcel H N Hoefnagel
    Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 29:5114-21. 2011
    ..b>Haemophilus influenzae type B (HiB) vaccine was chosen because its components exert different effects in vivo: while the HiB antigen,..
  26. ncbi Community effect of Haemophilus influenzae type b vaccination in India
    Valsan Philip Verghese
    Department of Child Health, Christian Medical College, Vellore, India
    Pediatr Infect Dis J 28:738-40. 2009
    We assessed the effect of distribution of Haemophilus influenzae type b (Hib) vaccine in the private health care sector on Hib meningitis admissions at a referral hospital in India. The annual mean number of Hib cases was 10...
  27. ncbi Immunogenicity, reactogenicity and safety of three-dose primary and booster vaccination with combined diphtheria-tetanus-whole-cell pertussis-hepatitis B-reduced antigen content Haemophilus influenzae type b vaccine in Filipino children
    Salvacion R Gatchalian
    Research Institute for Tropical Medicine, DOH Compound, Alabang, Muntinlupa City, Philippines
    Hum Vaccin 6:664-72. 2010
    ..To evaluate the immunogenicity, reactogenicity and safety of primary and booster vaccination with DTPw-HBVLT/Hib2.5 vaccine containing low thiomersal and reduced quantities of Hib polysaccharide (PRP)...
  28. pmc Characterization of antibodies to capsular polysaccharide antigens of Haemophilus influenzae type b and Streptococcus pneumoniae in human immune globulin intravenous preparations
    Malgorzata G Mikolajczyk
    U S Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Blood Research and Review, Division of Hematology, Laboratory of Plasma Derivatives, Bethesda, MD, USA
    Clin Diagn Lab Immunol 11:1158-64. 2004
    ..infections in primary immune deficiency disease (PIDD) patients involve encapsulated bacteria, mainly Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (pneumococcus)...
  29. ncbi Prevalence of oropharyngeal colonization by Haemophilus influenzae type b in Iranian children
    A Karimi
    Department of Paediatric Infectious Diseases, Faculty of Medicine, Shaheed Beheshti Medical University, Tehran, Islamic Republic of Iran
    East Mediterr Health J 15:544-8. 2009
    Healthy carriers of Haemophilus influenzae type b (Hib) play an important role in the spread of invasive disease...
  30. pmc Analysis of invasive Haemophilus influenzae infections after extensive vaccination against H. influenzae type b
    Jose Campos
    Instituto de Salud Carlos III División de Fármaco Vigilancia, Agencia Española del Medicamento, Ministry of Health, Majadahonda Instituto de Salud Pública, Consejeria de Sanidad, Comunidad de Madrid, Madrid, Spain
    J Clin Microbiol 42:524-9. 2004
    ..In the post-Hib vaccination era, most invasive infections were due to noncapsulated strains and occurred in the extreme ages of life in patients with predisposing conditions...
  31. pmc Kinetics of antibody persistence following administration of a combination meningococcal serogroup C and haemophilus influenzae type b conjugate vaccine in healthy infants in the United Kingdom primed with a monovalent meningococcal serogroup C vaccine
    Ray Borrow
    Vaccine Evaluation Unit, Health Protection Agency, Manchester Medical Microbiology Partnership, P O Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom
    Clin Vaccine Immunol 17:154-9. 2010
    ..of antibody persistence following the administration of a combination meningococcal serogroup C and Haemophilus influenzae type b (Hib) conjugate vaccine (Menitorix) in the second year of life in children primed with two doses of ..
  32. pmc Streptococcus pneumoniae and Haemophilus influenzae type B Carriage, Central Asia
    Stephanie H Factor
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:1476-9. 2005
    ..Approximately 6% of children carried Haemophilus influenzae type b (Hib)...
  33. pmc Accelerating introduction of new vaccines: barriers to introduction and lessons learned from the recent Haemophilus influenzae type B vaccine experience
    Rana Hajjeh
    Division of Bacterial Diseases, NCIRD, Centers for Disease Control and Prevention, 1600 Clifton Road, MS C 25, Atlanta, GA 30333, USA
    Philos Trans R Soc Lond B Biol Sci 366:2827-32. 2011
    ..Alliance for Vaccines and Immunization (GAVI) supported efforts to accelerate the introduction of Haemophilus influenzae type b (Hib) vaccines in developing countries, which resulted in a significant surge in vaccine adoption by ..
  34. pmc Modeling insights into Haemophilus influenzae type b disease, transmission, and vaccine programs
    Michael L Jackson
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 18:13-20. 2012
    In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and ..
  35. pmc Prevalence of Haemophilus influenzae type b genetic islands among clinical and commensal H. influenzae and H. haemolyticus isolates
    Sara A Sandstedt
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109 2029, USA
    J Clin Microbiol 48:2565-8. 2010
    Five genetic islands (HiGI) found in Haemophilus influenzae type b strain Eagan were used as hybridization probes on type b, Haemophilus haemolyticus, and nontypeable H. influenzae (NTHi) isolates...
  36. ncbi Reduction in osteomyelitis and septic arthritis related to Haemophilus influenzae type B vaccination
    A W Howard
    Division of Orthopaedics, Children s Hospital of Eastern Ontario, and University of Ottawa, Canada
    J Pediatr Orthop 19:705-9. 1999
    ..cohort study compares organisms responsible for septic arthritis and osteomyelitis before and after Haemophilus influenzae type b vaccination...
  37. ncbi Immune response to Haemophilus influenzae type B vaccination in renal transplant recipients with well-functioning allografts
    M S Sever
    Department of Nephrology, Istanbul School of Medicine, Millet Caddesi, Capa, Istanbul
    Nephron 81:55-9. 1999
    ..On the other hand, posttranplant immunosuppression may impair immune responses and thus the efficacy of the vaccination...
  38. ncbi Long term enhancement of the IgG2 antibody response to Haemophilus influenzae type b by breast-feeding
    Sven Arne Silfverdal
    Department of Pediatric, Orebro University Hospital, Orebro, Sweden
    Pediatr Infect Dis J 21:816-21. 2002
    ..Duration and mode of breast-feeding were monitored. Titers of IgG1, IgG2, IgA and IgM antibodies against Hib capsular polysaccharide were determined in sera taken during the acute illness and during early and late convalescence...
  39. pmc Loop-mediated isothermal amplification assay for detection of Haemophilus influenzae type b in cerebrospinal fluid
    Dong Wook Kim
    Molecular Bacteriology Laboratory, International Vaccine Institute, Seoul, Republic of Korea
    J Clin Microbiol 49:3621-6. 2011
    b>Haemophilus influenzae type b (Hib) is one of the leading causes of meningitis in developing countries...
  40. ncbi Combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C (HibMenC) or serogroup C and Y-tetanus toxoid conjugate (and HibMenCY) vaccines are well-tolerated and immunogenic when administered according to the 2,3,4 months schedule with
    Pirmin Habermehl
    Children s Hospital, University of Mainz, Germany
    Hum Vaccin 6:640-51. 2010
    ..study 792014 and 100381;www.clinicaltrial.govID:NCT00129116)..
  41. ncbi Immunogenicity and safety of a pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type B conjugate combination vaccine (Pentaxim) with hepatitis B vaccine
    A K Dutta
    Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Indian Pediatr 46:975-82. 2009
    ..To obtain immunogenicity and safety data for a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, inactivated poliovirus, Hib polysaccharide-conjugate)...
  42. ncbi Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007
    David W Scheifele
    Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
    Pediatr Infect Dis J 27:755-7. 2008
    The uniform use in Canada of a single Haemophilus influenzae type b conjugate vaccine in combination with diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccines (DTaP...
  43. pmc Position-based scanning for comparative genomics and identification of genetic islands in Haemophilus influenzae type b
    Nicholas H Bergman
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    Infect Immun 71:1098-108. 2003
    ....
  44. ncbi Incidence of childhood Haemophilus influenzae type b meningitis in Sri Lanka
    Ranjith Batuwanthudawe
    Epidemiology Unit, Ministry of Health, No 231, De Saram Place, Colombo 10, Sri Lanka
    Int J Infect Dis 14:e372-6. 2010
    To demonstrate the burden of Haemophilus influenzae type b (Hib) disease in Sri Lanka and provide information for decision-making in public health planning and vaccine introduction.
  45. ncbi Haemophilus influenzae type b immunization in infants in the United Kingdom: effects of diphtheria/tetanus/acellular pertussis/Hib combination vaccine, significant prematurity, and a fourth dose
    Janet E Berrington
    Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne, England
    Pediatrics 117:e717-24. 2006
    ..UK infants to explore the effects of (1) immunization with an acellular diphtheria/tetanus/pertussis/Haemophilus influenzae type b (DTPHib) combination vaccine, (2) significant preterm delivery, and (3) a fourth dose of conjugated ..
  46. ncbi Antibody to Haemophilus influenzae type b after routine and catch-up vaccination
    C L Trotter
    Immunisation Division, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, NW9 5EQ, London, UK
    Lancet 361:1523-4. 2003
    Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years...
  47. ncbi Haemophilus influenzae type b carriage in Indigenous children and children attending childcare centers in the Northern Territory, Australia, spanning pre- and post-vaccine eras
    Susan P Jacups
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Vaccine 29:3083-8. 2011
    This paper investigates Haemophilus influenzae type b (Hib) carriage in Indigenous children and children attending childcare centres in the Northern Territory of Australia, 1992-2005...
  48. ncbi Invasive disease due to Haemophilus influenzae type b during the first six years of general vaccination of Swedish children
    O Garpenholt
    Department of Clinical Microbiology, Orebro Medical Centre Hospital, Sweden
    Acta Paediatr 89:471-4. 2000
    Since 1992-93 vaccination against Haemophilus influenzae type b (Hib) has been included in the general Swedish childhood vaccination programme...
  49. ncbi Impact of non-routine vaccination on the incidence of invasive Haemophilus influenzae type b (Hib) disease: experience in the autonomous region of Valencia, Spain
    J Diez-Domingo
    Research Unit Trinitat, Vaccine Institute of Valencia, Spain
    J Infect 42:257-60. 2001
    ..This study assessed the impact of non-routine vaccination against invasive Haemophilus influenzae (Hib)disease before the introduction of universal childhood Hib vaccination...
  50. ncbi Clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhood
    P T Heath
    Oxford Vaccine Group, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Infect Dis 31:973-80. 2000
    b>Haemophilus influenzae type b (Hib) conjugate vaccines have proved extremely efficacious in healthy children. True Hib vaccine failures are rare...
  51. ncbi Haemophilus influenzae type b infection, vaccination, and H. influenzae carriage in children in Minnesota, 2008-2009
    S A Lowther
    Epidemic Intelligence Service, Division of Applied Sciences, Scientific Education and Professional Development Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Infect 140:566-74. 2012
    An increase in invasive Haemophilus influenzae type b (Hib) cases occurred in Minnesota in 2008 after the recommended deferral of the 12-15 months Hib vaccine boosters during a US vaccine shortage...
  52. pmc Bacterial meningitis and Haemophilus influenzae type b conjugate vaccine, Malawi
    David W McCormick
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Emerg Infect Dis 17:688-90. 2011
    A retrospective database review showed that Haemophilus influenzae type b conjugate vaccine decreased the annual number of cases of H. influenzae type b meningitis in children in Blantyre, Malawi...
  53. ncbi NTAGI subcommittee recommendations on Haemophilus influenzae type B (Hib) vaccine introduction in India
    Lalit Kant
    Subcommittee on Introduction of Hib Vaccine in Universal Immunization Program, National Technical Advisory Group on Immunization, India
    Indian Pediatr 46:945-54. 2009
    BACKGROUND: WHO estimates that Haemophilus influenzae type b (Hib) caused over 8 million cases of serious disease and 376,000 deaths globally in the year 2000...
  54. ncbi The beneficial impact of Hib vaccine on disease rates in New Zealand children
    Nick Wilson
    N Z Med J 115:U122. 2002
    To examine the impact of Haemophilus influenzae type b (Hib) vaccine on the burden of Haemophilus influenzae (Hi) disease in New Zealand children aged under five years (under-5s).
  55. ncbi The role of licA phase variation in the pathogenesis of invasive disease by Haemophilus influenzae type b
    Holly E Humphries
    University of Manchester, School of Biological Science, 1 800 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    FEMS Immunol Med Microbiol 34:221-30. 2002
    ..The ability to switch off the expression of licA through phase variation is therefore concluded to enhance the systemic survival of H. influenzae...
  56. ncbi Seroprotection associated with infant vitamin A supplementation given with vaccines is not related to antibody affinity to Hepatitis B and Haemophilus influenzae type b vaccines
    Sam Newton
    Kintampo Health Research Centre, Ghana
    Vaccine 28:4738-41. 2010
    ..of a pentavalent vaccine in 888 infants, antibody affinity analyses of the hepatitis B and Haemophilus influenzae type b components were investigated in infants given 15mg RE vitamin A with their vaccination and those who ..
  57. pmc Indirect protection obtained by Haemophilus influenzae type b vaccination: analysis in a structured population model
    T Leino
    National Public Health Institute, Helsinki, Finland
    Epidemiol Infect 132:959-66. 2004
    ..a structured population model to study factors determining the magnitude of indirect protection in Haemophilus influenzae type b (Hib) vaccination...
  58. ncbi Up-to-date Haemophilus influenzae type b vaccination coverage during a vaccine shortage
    Karen E White
    Minnesota Department of Health, Immunization, Tuberculosis and International Health, 625 Robert St N, Saint Paul, MN 55164, USA
    Pediatrics 127:e707-12. 2011
    We sought to assess Haemophilus influenzae type b (Hib) vaccination coverage in diverse areas of the United States during the 2008-2009 Hib vaccine shortage...
  59. ncbi The impact of vaccines on pneumonia: key lessons from Haemophilus influenzae type b conjugate vaccines
    Bradford D Gessner
    Agence de Medecine Preventive, Institut Pasteur, 28 rue du Doctor Roux, F 75724 Paris, France
    Vaccine 26:B3-8. 2008
    This article explores key lessons learned from vaccination with Haemophilus influenzae type b (Hib) conjugate vaccine and how these lessons may provide insight into the impact of emergent pneumococcal vaccines against pneumonia...
  60. ncbi [Role of Haemophilus influenzae b and pneumococcus in bacterial meningitis in Vietnam (1995-1997)]
    Tan Tram Tran
    Arch Pediatr 11:373-4. 2004
  61. ncbi Safety and immunogenicity of a conjugate vaccine against Haemophilus influenzae type b in splenectomized and nonsplenectomized patients with Cooley anemia
    R Cimaz
    Clinica Pediatrica De Marchi, Istituti Clinici di Perfezionamento, 20122 Milan, Italy
    J Infect Dis 183:1819-21. 2001
    ..antimicrobial prophylaxis are recommended in these patients, but the optimal immunization schedule for Haemophilus influenzae type b (Hib) vaccine is unknown...
  62. ncbi School-aged children: a reservoir for continued circulation of Haemophilus influenzae type b in the United Kingdom
    S Y Oh
    Oxford Vaccine Group, University Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    J Infect Dis 197:1275-81. 2008
    A resurgence of Haemophilus influenzae type b (Hib) disease occurred in the United Kingdom between 1999 and 2003 and was partially attributed to lower immunogenicity of combination vaccines...
  63. pmc Long-term impact of vaccination on Haemophilus influenzae type b (Hib) carriage in the United Kingdom
    J McVernon
    Immunisation Department, Health Protection Agency Communicable Disease Surveillance Centre, Colindale, London, UK
    Epidemiol Infect 132:765-7. 2004
    A recent resurgence in serious infections due to Haemophilus influenzae type b (Hib) has been observed in the United Kingdom...
  64. ncbi Antibody concentration and clinical protection after Hib conjugate vaccination in the United Kingdom
    P T Heath
    Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, England
    JAMA 284:2334-40. 2000
    The schedule for Haemophilus influenzae type b (Hib) vaccination of infants in the United Kingdom consists of 3 doses given at 2, 3, and 4 months of age...
  65. ncbi Genetic and phenotypic characterization of Haemophilus influenzae type b isolated from children with meningitis and their family members in Vietnam
    L T Huong Phan
    Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    Jpn J Infect Dis 59:111-6. 2006
    To investigate Haemophilus influenzae type b (Hib) infection in Vietnamese children under the age of 5 years, cerebrospinal fluid (CSF) samples from patients with meningitis were screened for Hib, and isolates were subjected to ..
  66. ncbi Rethinking the benefits and costs of childhood vaccination: the example of the Haemophilus influenzae type b vaccine
    Till Barnighausen
    Department of Global Health and Population, Harvard School of Public Health, USA
    Vaccine 29:2371-80. 2011
    ..Using the example of cost-benefit analysis (CBA) of Haemophilus influenzae type b (Hib) vaccination, we demonstrate that past economic evaluations have mostly adopted narrow evaluation ..
  67. ncbi Haemophilus influenzae type b (Hib) antibody concentrations and vaccination responses in patients with chronic lymphocytic leukaemia: predicting factors for response
    Marjatta Sinsalo
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
    Leuk Lymphoma 43:1967-9. 2002
    We have recently demonstrated a moderate vaccination response rate of 43% against Haemophilus influenzae type b (Hib) conjugate vaccine among adult and elderly patients with chronic lymphocytic leukaemia (CLL)...
  68. ncbi Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants
    Alexander H Lucas
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Clin Immunol 108:119-27. 2003
    ..V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune response to the Haemophilus influenzae type b (Hib) capsular polysaccharide (PS)...
  69. ncbi High levels of multiple antibiotic resistance among 938 Haemophilus influenzae type b meningitis isolates from Cuba (1990-2002)
    Isis Tamargo
    Laboratorio Nacional de Referencia de Haemophilus, Instituto de Medicina Tropical, La Habana, Cuba
    J Antimicrob Chemother 52:695-8. 2003
    A national surveillance study to determine antimicrobial susceptibility in Haemophilus influenzae type b isolated from cerebrospinal fluid was carried out in Cuba from 1990 to 2002.
  70. ncbi Introducing new vaccines in developing countries: concepts and approaches to estimating burden of Haemophilus influenzae type b-associated disease
    Paul E Kilgore
    International Vaccine Institute, Seoul 151 600, Republic of Korea
    J Health Popul Nutr 22:246-56. 2004
    ..Despite this, the introduction of Haemophilus influenzae type b (Hib) vaccines has progressed rather slowly compared to previously-introduced vaccines for infant ..
  71. ncbi A new combination haemophilus influenzae type B and Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine for primary immunization of infants
    David Pace
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK
    Pediatr Infect Dis J 26:1057-9. 2007
    ..a phase 3 randomized controlled trial looking at the immunogenicity and safety of a novel combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine, Hib-MenC-TT in a 2-, 3-, and ..
  72. ncbi Catch-up vaccination against Haemophilus influenzae type b in human immunodeficiency virus-infected Thai children older than 2 years old
    Kulkanya Chokephaibulkit
    Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok Noi, Bangkok 10700, Thailand
    Vaccine 22:2018-22. 2004
    Although most of Thai children older than 2 years are immune against Haemophilus influenzae type b (Hib) without prior vaccination, it may not be the case in HIV-infected children...
  73. ncbi Haemophilus influenzae type B meningitis among children in Hanoi, Vietnam: epidemiologic patterns and estimates of H. Influenzae type B disease burden
    Dang D Anh
    Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    Am J Trop Med Hyg 74:509-15. 2006
    From March 2000 to February 2002, a population-based study of Haemophilus influenzae type b (Hib) meningitis was conducted among children less than five years of age in Hanoi, Vietnam...
  74. ncbi Estimating the Haemophilus influenzae type b (Hib) disease burden and the impact of Hib vaccine in Fiji
    Nick Wilson
    367a Karori Road, Karori, Wellington, New Zealand
    Vaccine 21:1907-12. 2003
    To estimate Haemophilus influenzae type b (Hib) disease burden in Fiji in children under the age of 5 years (under-5s) prior to vaccine introduction...
  75. ncbi The induction of immunologic memory after vaccination with Haemophilus influenzae type b conjugate and acellular pertussis-containing diphtheria, tetanus, and pertussis vaccine combination
    D Goldblatt
    Immunobiology Unit, Institute of Child Health, London WC1N 1EH, UK
    J Infect Dis 180:538-41. 1999
    The significance of reduced antibody responses to the Haemophilus influenzae type b (Hib) component of acellular pertussis-containing combination vaccines (DTaP-Hib) is unclear...
  76. ncbi Immune response of premature infants to meningococcal serogroup C and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b conjugate vaccines
    M H Slack
    Department of Neonatal Medicine, Princess Anne Hospital, Southampton, United Kingdom
    J Infect Dis 184:1617-20. 2001
    ..serogroup C capsular polysaccharide (MCC) and combined diphtheria-tetanus toxoids-acellular pertussis-Haemophilus influenzae type b (DTaP-Hib) conjugate vaccines, 105 infants born at <32 weeks' gestation had Hib IgG geometric mean ..
  77. ncbi Economic evaluations of Haemophilus influenzae type b vaccine: systematic review of the literature
    Ulla K Griffiths
    Hib Initiative, Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Expert Rev Pharmacoecon Outcomes Res 9:333-46. 2009
    ..b>Haemophilus influenzae type b (Hib) vaccine has been available since the early 1990s, but uptake of the vaccine was slow in low-..
  78. ncbi Haemophilus influenzae type b vaccine impact in resource-poor settings in Asia and Africa
    Bradford D Gessner
    Agence de Medecine Preventive, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Expert Rev Vaccines 8:91-102. 2009
    The Haemophilus influenzae type b (Hib) conjugate vaccine has been administered for almost 20 years in developed countries with remarkable success...
  79. ncbi Is a NAD pyrophosphatase activity necessary for Haemophilus influenzae type b multiplication in the blood stream?
    J Schmidt-Brauns
    Zentrum für Infektionsforschung, Universitat Wurzburg, Germany
    Int J Med Microbiol 291:219-25. 2001
    ..NAD pyrophosphatase and NMN 5'-nucleotidase activities were present in rat and human serum, implying that under infection conditions H. influenzae may obtain NR directly from its host...
  80. ncbi Foresight in medicine: current challenges with Haemophilus influenzae type b conjugate vaccines
    J Eskola
    National Institute for Health and Welfare, FI 00271 Helsinki, Finland
    J Intern Med 267:241-50. 2010
    An effective vaccine to prevent invasive infections caused by Haemophilus influenzae type b (Hib) bacteria has been available for more than 20 years...
  81. ncbi The Elimination of Haemophilus influenzae type b meningitis following conjugate vaccine introduction in Senegal
    Moussa Fafa Cisse
    Children s Hospital Albert Royer, Dakar, Senegal
    Pediatr Infect Dis J 29:499-503. 2010
    Senegal introduced routine infant Haemophilus influenzae type b (Hib) conjugate vaccine during 2005.
  82. pmc Spectrum and burden of severe Haemophilus influenzae type b diseases in Asia
    H Peltola
    HUCH Hospital for Children and Adolescents, Helsinki, Finland
    Bull World Health Organ 77:878-87. 1999
    The validity of the commonly held view that Haemophilus influenzae type b (Hib) diseases are rare in Asia is challenged in this article by a thorough analysis of the data available, often in languages other than English...
  83. ncbi Epidemiology of pertussis and Haemophilus influenzae type b disease in Canada with exclusive use of a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b pediatric combination vaccine and an adolescent-adult tetanus
    David P Greenberg
    Sanofi Pasteur Inc Swiftwater, PA, USA
    Pediatr Infect Dis J 28:521-8. 2009
    ..the decade 1998-2007, a combination DTaP(5)-IPV/Hib vaccine was used exclusively in Canada to immunize infants and young children against diphtheria, tetanus, pertussis, polio, and invasive Haemophilus influenzae type b (Hib) disease.
  84. ncbi The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence
    Paul Daza
    Mzuzu Central Hospital, Mzuzu, Malawi
    Vaccine 24:6232-9. 2006
    Malawi has extreme poverty and a high-human immunodeficiency virus (HIV) prevalence. Following Haemophilus influenzae type b (Hib) conjugate vaccine introduction during 2002, we evaluated vaccine impact by reviewing hospital surveillance ..
  85. ncbi Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae
    Caroline L Trotter
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    Vaccine 26:4434-45. 2008
    Conjugate vaccines exist that offer protection against disease caused by Haemophilus influenzae type b (Hib), and selected serogroups/serotypes of Neisseria meningitidis and Streptococcus pneumoniae...
  86. ncbi Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil
    Guilherme S Ribeiro
    Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
    J Infect Dis 187:109-16. 2003
    ..However, these findings highlight the need to maintain surveillance as the use of conjugate vaccines expands worldwide...
  87. pmc Haemophilus influenzae type b conjugate vaccines
    Dominic F Kelly
    Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    Immunology 113:163-74. 2004
    b>Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children worldwide...
  88. pmc The Haemophilus influenzae Type b hcsA and hcsB gene products facilitate transport of capsular polysaccharide across the outer membrane and are essential for virulence
    Soila Sukupolvi-Petty
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Bacteriol 188:3870-7. 2006
    b>Haemophilus influenzae type b is a common cause of invasive bacterial disease, especially among children in underdeveloped countries...
  89. ncbi Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age
    Robert Booy
    National Centre for Immunisation Research and Surveillance, The Children s Hospital at Westmead, Sydney, Australia
    Pediatr Infect Dis J 30:340-2. 2011
    ..15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively...
  90. pmc Immunization coverage and risk factors for failure to immunize within the Expanded Programme on Immunization in Kenya after introduction of new Haemophilus influenzae type b and hepatitis b virus antigens
    Moses Ndiritu
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    BMC Public Health 6:132. 2006
    Kenya introduced a pentavalent vaccine including the DTP, Haemophilus influenzae type b and hepatitis b virus antigens in Nov 2001 and strengthened immunization services...
  91. ncbi Invasive Haemophilus influenzae type b disease in Sweden 1997-2003: epidemiological trends and patterns in the post-vaccine era
    Daniel Farhoudi
    Department of Epidemiology, Swedish Institute for Infectious Disease Control SMI, Solna, Sweden
    Scand J Infect Dis 37:717-22. 2005
    ..Together with a shift in age distribution towards adults this points to women aged +30 y as a potential new risk group. This may reflect an increased risk owing to women being the primary carers of young children...
  92. pmc Modelling transmission, immunity and disease of Haemophilus influenzae type b in a structured population
    K Auranen
    Department of Vaccines, National Public Health Institute, Finland
    Epidemiol Infect 132:947-57. 2004
    An individual-based stochastic simulation model was constructed to study the epidemiology of Haemophilus influenzae type b (Hib) transmission, immunity and invasive disease...
  93. ncbi Haemophilus influenzae Type b disease among Amish children in Pennsylvania: reasons for persistent disease
    A M Fry
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Atlanta, GA 30333, USA
    Pediatrics 108:E60. 2001
    To identify reservoirs of Haemophilus influenzae type b (Hib) pharyngeal carriage and assess barriers to vaccination among 2 Amish communities in Pennsylvania.
  94. ncbi Presence of multiple copies of the capsulation b locus in invasive Haemophilus influenzae type b (Hib) strains isolated from children with Hib conjugate vaccine failure
    Marina Cerquetti
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Infect Dis 192:819-23. 2005
    Most invasive Haemophilus influenzae type b strains possess a duplication of the capsulation locus. Further amplification resulting in as many as 5 copies has been described...
  95. ncbi Four and one-half-year follow-up of the effectiveness of diphtheria-tetanus toxoids-acellular pertussis/Haemophilus influenzae type b and diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus/H. influenzae type b combination vaccines in Ge
    Helen Kalies
    Institute for Social Pediatrics and Adolescent Medicine, Ludwig Maxilimilians University, Heiglhofstrasse 63, 81377 Munich, Germany
    Pediatr Infect Dis J 23:944-50. 2004
    Recently an increase in the number of invasive Haemophilus influenzae type b (Hib) cases was observed in the United Kingdom, which coincided with a temporary change from diphtheria-tetanus toxoids-wild-type pertussis to diphtheria-..
  96. ncbi Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates
    James P Watt
    Hib Initiative, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 374:903-11. 2009
    b>Haemophilus influenzae type b (Hib) is a leading cause of childhood bacterial meningitis, pneumonia, and other serious infections. Hib disease can be almost completely eliminated through routine vaccination...
  97. ncbi Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study
    Richard A Adegbola
    Medical Research Council Laboratories, The Gambia
    Lancet 366:144-50. 2005
    Routine immunisation of infants in The Gambia with a Haemophilus influenzae type b (Hib) polysaccharide-tetanus toxoid conjugate vaccine began in May, 1997...
  98. ncbi Detection of antigenuria for diagnosis of invasive Haemophilus influenzae type b disease
    Samir K Saha
    Department of Microbiology, Dhaka Shishu Children s Hospital, Dhaka, Bangladesh
    Ann Trop Paediatr 26:329-36. 2006
    b>Haemophilus influenzae type b (Hib) diseases are responsible for an estimated 400,000 childhood deaths, mostly in developing countries.
  99. pmc Effectiveness of Haemophilus influenzae type b Conjugate vaccine introduction into routine childhood immunization in Kenya
    Karen D Cowgill
    Epidemic Intelligence Service, Epidemiology Program Office, Division of Applied Public Health Training, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 296:671-8. 2006
    b>Haemophilus influenzae type b (Hib) conjugate vaccine is not perceived as a public health priority in Africa because data on Hib disease burden and vaccine effectiveness are scarce...
  100. ncbi Aetiology of bacterial meningitis and resistance to antibiotics of causative pathogens in Europe and in the Mediterranean region
    Georgina Tzanakaki
    National Meningitis Reference Laboratory, National School of Public Health, Athens, Greece
    Int J Antimicrob Agents 29:621-9. 2007
    Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae type b are most commonly associated with bacterial meningitis accounting for almost 90% of reported cases of acute bacterial meningitis in infants over 60 days ..
  101. ncbi A randomised trial of a Haemophilus influenzae type b conjugate vaccine in a developing country for the prevention of pneumonia--ethical considerations
    K Mulholland
    Vaccines and Other Biologicals, World Health Organization, Geneva, Switzerland
    Int J Tuberc Lung Dis 3:749-55. 1999
    In 1993 a placebo-controlled field trial of a Haemophilus influenzae type b (Hib) conjugate vaccine was started in The Gambia...

Research Grants44

  1. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Moreover, the epidemiology of childhood pneumonia is changing due to the impact of Haemophilus influenzae type b (Hib) vaccine and pneumococcal conjugate vaccine, and the emergence of non-vaccine serotypes of ..
  2. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ABSTRACT Current vaccines against Haemophilus influenzae type b have reduced the incidence of H. influenzae type b invasive diseases...
  3. Laser-based powder vaccine delivery for improved newborn immunization
    Xinyuan Chen; Fiscal Year: 2013
    ..Polysaccharide-encapsulated bacteria, such as Haemophilus influenzae type b (Hib), are leading causes of serious infections in infants...
  4. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2004
    ..The strategy will incorporate features of the highly successful Haemophilus influenzae type b and pertussis vaccines that utilize defined surface virulence determinants, colonization factors, and ..
  5. THE EFFICACY OF CONJUGATE VACCINES AGAINST H INFLUENZAE
    Eugene Shapiro; Fiscal Year: 1993
    b>Haemophilus influenzae type b is the most common cause of bacterial meningitis and other serious invasive bacterial infections in children...
  6. INTERACTION OF COMPLEMENT AND HAEMOPHILUS INFLUENZAE
    K Cates; Fiscal Year: 1991
    ..b>Haemophilus influenzae type b (Hib), the most common cause of bacterial meningitis in children, is resistant to alternative pathway-..
  7. GENETIC CONTROL OF ANTIBODY RESPONSES TO POLYSACCHARIDES
    Dan Granoff; Fiscal Year: 1993
    ..1, we will investigate the immunologic and genetic basis of "vaccine failure" in patients who develop Haemophilus influenzae type b (Hib) disease despite previous vaccination with Hib polysaccharide (PS) vaccine...
  8. Haemophilus influenzae iron/heme regulon
    Terrence Stull; Fiscal Year: 2007
    Current vaccines against Haemophilus influenzae type b have reduced the incidence of H. influenzae type b invasive diseases...
  9. GENETIC ANALYSIS OF H. INFLUENZAE CAPSULE EXPRESSION
    SUSAN HOISETH; Fiscal Year: 1992
    The Haemophilus influenzae type b capsule has long been recognized as an important virulence determinant. Capsule expression, however, is genetically unstable, and capsule-deficient mutants arise at frequencies of 0.1 to 0.5%...
  10. HAEMOPHILUS INFLUENZAE B CONJUGATE VACCINE EFFICACY
    Joel Ward; Fiscal Year: 1993
    ..of this proposal is to assess by case-control methods the protective efficacy characteristics of Haemophilus influenzae type b (Hib) conjugate vaccines to be licensed by 1991 for routine immunization of infants 2 to 6 months of ..
  11. SPECIFIC ENVELOPE COMPONENTS OF H. INFLUENZAE TYPE B
    FRANCIS BUCKMIRE; Fiscal Year: 1980
    Specific envelope components which have been related to virulence in Haemophilus influenzae type b will be characterized. Among the six serotypes of H. influenzae, type b is most frequently associated with severe human infections. H...
  12. HEMOPHILUS INFLUENZAE TYPE B INFECTIONS
    Carl Norden; Fiscal Year: 1980
    ..project is to continue to investigate immunity and other mechanisms of resistance to infection with Haemophilus influenzae type b. We are investigating the role of serum bactericidal activity in protection against Haemophilus ..
  13. VIRAL POTENTIATION OF BACTERIAL INFECTION
    RICHARD MICHAELS; Fiscal Year: 1980
    We propose to try to determine how influenza virus infection potentiates the genic potential of Haemophilus influenzae type b (Hitb) in infant rats...
  14. PROPERTIES OF THE 3RD AND 4TH COMPLEMENT PROTEINS
    R Levine; Fiscal Year: 1990
    ....
  15. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..
  16. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  17. E. COLI BINDING TO BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ....
  18. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  19. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  20. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  21. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  22. Regulation of T-cell DNA Methylation
    John Attwood; Fiscal Year: 2006
    ..abstract_text> ..
  23. CONSTRUCTION OF THE VACCINE CENTER
    ALEXANDER LUCAS; Fiscal Year: 2002
    ..Construction of the CIVD will expand investigators' research capabilities, promote programmatic interaction and growth, increase training opportunities, and permit recruitment of additional scientists. ..
  24. In-Home Prevention of SA risks in Native Teen Families
    John T Walkup; Fiscal Year: 2010
    ....
  25. Control of Accessibility for V(D) J Recombination
    ANN FEENEY; Fiscal Year: 2006
    ..We will determine if other transcription factors such as Pax5 or Btk will induce rearrangement of other Ig loci, such as Vh or lambda. ..
  26. Receptor Editing in Autoimmune and Normal Mice
    ANN FEENEY; Fiscal Year: 2009
    ..The information gained in these aims should give insights into the response of the various Ig loci to receptor editing signals, and how these processes may potentially be misregulated in B cells of autoimmune mice. ..
  27. B CELL REPERTOIRE FORMATION
    ANN FEENEY; Fiscal Year: 2009
    ..Together, these studies should give insight into the epigenetic mechanisms and cis-elements which control VH gene rearrangement in fetal and adult pro-B cells. ..
  28. Short Tandem Repeat Polymorphisms in Cytomegalovirus
    James Bale; Fiscal Year: 2003
    ..Characterizing HCM' strains by STR analysis will facilitate future studies of HCMV evolution and will provide a novel means t to fingerprint HCMV strains. ..
  29. THE EFFECTIVENESS OF VACCINES IN CLINICAL PRACTICE
    Eugene Shapiro; Fiscal Year: 2004
    ..Shapiro to review their progress and to help them develop their own studies as well as to develop strategies for the development of their careers. ..
  30. Regulation of GRP94: Targeting Novel Cancer Therapeutics
    Jeffrey Baker; Fiscal Year: 2004
    ..Together, the proposed analysis will lead to a greater understanding of GRP94 as a novel anti-cancer target. ..
  31. Pilot Study of Automated Surveillance to Measure Burden
    Paul Kilgore; Fiscal Year: 2007
    ..We will assess the potential use of the phone/web-based case reporting system for measuring the impact of health interventions including vaccines. [unreadable] [unreadable] [unreadable]..
  32. Neisseria meningitidis antigens expressed in infection
    Dan Granoff; Fiscal Year: 2005
    ..meningitidis disease, including group B strains for which there is currently no vaccine available. Also, characterization of gene expression in an in vivo model will lead to a better understanding of meningococcal pathogenesis. ..
  33. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
  34. Appropriate Pneumococcal Vaccination in Infants in Fiji
    EDWARD MULHOLLAND; Fiscal Year: 2005
    ..This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. ..
  35. Reducing Transmission of Influenza by Face Masks
    ARNOLD MONTO; Fiscal Year: 2008
    ..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
  36. Comparative Study of Influenza Vaccines in Adults
    ARNOLD MONTO; Fiscal Year: 2006
    ..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
  37. Training in Patient-Oriented Research for Physicians
    Eugene Shapiro; Fiscal Year: 2006
    ..Ultimately, the Yale CRS Program will help to increase the pool of physician-investigators who will be uniquely poised to conduct research to directly improve the health of all Americans. [unreadable] [unreadable] [unreadable]..
  38. Molecular basis meningococcal group A capsular immunity
    Dan Granoff; Fiscal Year: 2007
    ..abstract_text> ..
  39. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005
    ..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..
  40. Polysaccharide Antibody Repertoires
    Alexander H Lucas; Fiscal Year: 2010
    ..specific for Streptococcus pneumoniae polysaccharide serotypes 14 (PPS 14) and 23F (PPS 23F) and the Haemophilus influenzae type b capsular polysaccharide (Hib PS)...
  41. MOLECULAR ANALYSIS OF THE ANTIH INFLUENZAE RESPONSE
    ANN FEENEY; Fiscal Year: 2001
    ..We will also further analyze the diversity in the ani-hib response through the use of combinatorial libraries, correlating affinity with the Vh, Vk and CDR3's which are used. ..
  42. Effectiveness of Varicella Vaccine in Clinical Practice
    Eugene Shapiro; Fiscal Year: 2006
    ..abstract_text> ..