haemophilus influenzae

Summary

Summary: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.

Top Publications

  1. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
  2. pmc Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung
    Jeffrey D Gawronski
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, S6 242, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:16422-7. 2009
  3. pmc Microbial gene identification using interpolated Markov models
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 26:544-8. 1998
  4. pmc Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR
    C E Corless
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, United Kingdom
    J Clin Microbiol 39:1553-8. 2001
  5. pmc Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants
    Brenda A Kwambana
    Bacterial Diseases Programme, Medical Research Council Laboratories UK, Atlantic Boulevard, Banjul, PO Box 273, The Gambia
    BMC Infect Dis 11:175. 2011
  6. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
  7. pmc Transformation of natural genetic variation into Haemophilus influenzae genomes
    Joshua Chang Mell
    University of British Columbia, Department of Zoology, Vancouver, British Columbia, Canada
    PLoS Pathog 7:e1002151. 2011
  8. ncbi Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation
    Richard Moxon
    Oxford University Department of Paediatrics, Molecular Infectious Diseases Group, Weatherall Institute of Molecular Medicine Oxford, United Kingdom
    Annu Rev Genet 40:307-33. 2006
  9. pmc DNA as a nutrient: novel role for bacterial competence gene homologs
    S E Finkel
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    J Bacteriol 183:6288-93. 2001
  10. ncbi Haemophilus influenzae: a significant pathogen in acute otitis media
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 23:1142-52. 2004

Detail Information

Publications257 found, 100 shown here

  1. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    ..This study assessed the efficacy of a novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein D in prevention of acute otitis media.
  2. pmc Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung
    Jeffrey D Gawronski
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, S6 242, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:16422-7. 2009
    ..This approach was applied to comprehensively identify Haemophilus influenzae genes required to delay bacterial clearance in a murine pulmonary model...
  3. pmc Microbial gene identification using interpolated Markov models
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 26:544-8. 1998
    This paper describes a new system, GLIMMER, for finding genes in microbial genomes. In a series of tests on Haemophilus influenzae , Helicobacter pylori and other complete microbial genomes, this system has proven to be very accurate at ..
  4. pmc Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR
    C E Corless
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR, United Kingdom
    J Clin Microbiol 39:1553-8. 2001
    ..developed on the ABI 7700 Sequence Detection System (TaqMan) for the detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae from clinical samples of cerebrospinal fluid (CSF), plasma, serum, and whole ..
  5. pmc Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants
    Brenda A Kwambana
    Bacterial Diseases Programme, Medical Research Council Laboratories UK, Atlantic Boulevard, Banjul, PO Box 273, The Gambia
    BMC Infect Dis 11:175. 2011
    Although Haemophilus influenzae type b (Hib), Staphylococcus aureus and Moraxella catarrhalis are important causes of invasive and mucosal bacterial disease among children, co-carriage with Streptococcus pneumoniae during infancy has not ..
  6. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
    ..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
  7. pmc Transformation of natural genetic variation into Haemophilus influenzae genomes
    Joshua Chang Mell
    University of British Columbia, Department of Zoology, Vancouver, British Columbia, Canada
    PLoS Pathog 7:e1002151. 2011
    ..We used DNA from a clinical isolate of Haemophilus influenzae to transform competent cells of a laboratory strain...
  8. ncbi Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation
    Richard Moxon
    Oxford University Department of Paediatrics, Molecular Infectious Diseases Group, Weatherall Institute of Molecular Medicine Oxford, United Kingdom
    Annu Rev Genet 40:307-33. 2006
    ..These SSRs are located within the reading frame or in the promoter of a subset of genes, often termed contingency loci, whose functions are usually involved in direct interactions with host structures...
  9. pmc DNA as a nutrient: novel role for bacterial competence gene homologs
    S E Finkel
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    J Bacteriol 183:6288-93. 2001
    ..as a nutrient depends on homologs of proteins involved in natural genetic competence and transformation in Haemophilus influenzae and Neisseria gonorrhoeae. Homologs of these E...
  10. ncbi Haemophilus influenzae: a significant pathogen in acute otitis media
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 23:1142-52. 2004
    b>Haemophilus influenzae is a major pathogen in acute otitis media (AOM) causing disease that is not clinically distinguishable from that caused by Streptococcus pneumoniae. AOM caused by H...
  11. ncbi Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, N C, USA
    J Innate Immun 1:215-24. 2009
    Nontypeable Haemophilus influenzae (NTHi) is a leading cause of acute and chronic otitis media, which are a major public health problem worldwide...
  12. pmc Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
    ....
  13. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..virus (RSV), human parainfluenza virus 3 (HPIV-3), and influenza virus on the abilities of nontypeable Haemophilus influenzae and Streptococcus pneumoniae to adhere to respiratory epithelial cells and how these viruses alter the ..
  14. ncbi Colonization of healthy children by Moraxella catarrhalis is characterized by genotype heterogeneity, virulence gene diversity and co-colonization with Haemophilus influenzae
    Suzanne J C Verhaegh
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    Microbiology 157:169-78. 2011
    ..5, 6, 14 and 24 months of age, yielding a total of 709 M. catarrhalis and 621 Haemophilus influenzae isolates...
  15. pmc Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
    Joseph A Jurcisek
    Columbus Children s Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205 2696, USA
    J Bacteriol 189:3868-75. 2007
    Nontypeable Haemophilus influenzae (NTHI) strains are members of the normal human nasopharyngeal flora, as well as frequent opportunistic pathogens of both the upper and lower respiratory tracts...
  16. ncbi Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    b>Haemophilus influenzae is a common pathogen in adults with chronic obstructive pulmonary disease (COPD). In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype...
  17. ncbi Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004
    Nontypeable Haemophilus influenzae colonizes the respiratory tract of adults with chronic obstructive pulmonary disease (COPD) and causes intermittent exacerbations. Isolates of H...
  18. pmc Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps
    Richard A Juneau
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5053 Hanes Building, 1000 Medical Center Boulevard, Winston Salem, NC 27157, USA
    Infect Immun 79:431-8. 2011
    Nontypeable Haemophilus influenzae (NTHI) is a leading cause of otitis media infections, which are often chronic and/or recurrent in nature...
  19. pmc Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation
    Guoyu Meng
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai JiaoTong University School of Medicine, PR China
    EMBO J 30:3864-74. 2011
    ..In this study, we used the Haemophilus influenzae Hap autotransporter as a prototype SAAT to understand how bacteria associate with each other...
  20. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  21. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
    Nontypeable Haemophilus influenzae (NTHi) is a leading causative agent of otitis media. Much of the inflammation occurring during NTHi disease is initiated by lipooligosaccharides (LOS) on the bacterial surface...
  22. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
    Nontypeable Haemophilus influenzae (NTHI) is an important pathogen in respiratory tract infections, including otitis media (OM)...
  23. pmc The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya
    Osman Abdullahi
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 27:59-64. 2008
    Transmission and nasopharyngeal colonization are necessary steps en route to invasive pneumococcal or Haemophilus influenzae disease but their patterns vary geographically...
  24. pmc Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    PLoS Pathog 7:e1002244. 2011
    ..b>Haemophilus influenzae has been isolated from the airways of neutrophilic asthmatics; however, the nature of the association ..
  25. pmc Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20
    Alistair Harrison
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43205, USA
    J Bacteriol 187:4627-36. 2005
    In 1995, the Institute for Genomic Research completed the genome sequence of a rough derivative of Haemophilus influenzae serotype d, strain KW20. Although extremely useful in understanding the basic biology of H...
  26. ncbi Nontypeable Haemophilus influenzae as a pathogen in children
    Timothy F Murphy
    University at Buffalo, The State University of New York, Buffalo, NY
    Pediatr Infect Dis J 28:43-8. 2009
    Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H...
  27. ncbi Detection of bacterial pathogens in Mongolia meningitis surveillance with a new real-time PCR assay to detect Haemophilus influenzae
    Xin Wang
    Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Int J Med Microbiol 301:303-9. 2011
    Since the implementation of Haemophilus influenzae (Hi) serotype b vaccine, other serotypes and non-typeable strains have taken on greater importance as a cause of Hi diseases...
  28. ncbi Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children
    Peter Jacoby
    Centre for Child Health Research, Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
    Pediatr Infect Dis J 30:480-5. 2011
    Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media (OM). Data are limited on risk factors for carriage of these pathogens, particularly for Indigenous populations...
  29. pmc The Haemophilus influenzae Hia adhesin is an autotransporter protein that remains uncleaved at the C terminus and fully cell associated
    J W St Geme
    Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Bacteriol 182:6005-13. 2000
    Nontypeable Haemophilus influenzae is a gram-negative commensal organism that is commonly associated with localized respiratory tract disease...
  30. pmc Viral-bacterial co-infection in Australian Indigenous children with acute otitis media
    Michael J Binks
    Ear and Respiratory Unit, Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    BMC Infect Dis 11:161. 2011
    ..Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the primary bacterial pathogens of otitis media and their loads predict ..
  31. pmc Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era
    Aarti Agrawal
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    J Clin Microbiol 49:3728-32. 2011
    The widespread use of Haemophilus influenzae type b (Hib) conjugate vaccines has nearly eradicated invasive Hib disease where the vaccines are used. This success was accompanied by a shift in capsular serotypes of invasive H...
  32. pmc RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP
    Chelsie E Armbruster
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Mol Microbiol 82:836-50. 2011
    Nontypeable Haemophilus influenzae (NTHI) is a respiratory commensal and opportunistic pathogen, which persists within biofilms on airway mucosal surfaces. For many species, biofilm formation is impacted by quorum signalling...
  33. pmc Association of IS1016 with the hia adhesin gene and biotypes V and I in invasive nontypeable Haemophilus influenzae
    Sarah W Satola
    Atlanta Veterans Affairs Medical Center and Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Infect Immun 76:5221-7. 2008
    A subset of invasive nontypeable Haemophilus influenzae (NTHI) strains has evidence of IS1016, an insertion element associated with division I H. influenzae capsule serotypes...
  34. pmc Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype
    Seyed Javad Moghaddam
    Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Am J Respir Cell Mol Biol 38:629-38. 2008
    Nontypeable Haemophilus influenzae (NTHi) commonly colonizes the lower airways of patients with chronic obstructive pulmonary disease (COPD). Whether it contributes to COPD progression is unknown...
  35. pmc Pharyngeal colonization dynamics of Haemophilus influenzae and Haemophilus haemolyticus in healthy adult carriers
    Deepa Mukundan
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0244, USA
    J Clin Microbiol 45:3207-17. 2007
    b>Haemophilus influenzae is an important cause of respiratory infections, including acute otitis media, sinusitis, and chronic bronchitis, which are preceded by asymptomatic H. influenzae colonization of the human pharynx...
  36. pmc Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains
    Justin S Hogg
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
    Genome Biol 8:R103. 2007
    ..Studies based on random sequencing of multiple strain libraries suggested that free-living bacterial species possess a supragenome that is much larger than the genome of any single bacterium...
  37. ncbi Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Bertsham, South Africa
    J Infect Dis 196:1662-6. 2007
    ..HIV)-infected children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6% and 74.1%, respectively) than did HIV-uninfected children (n=271; 50.9% and 52...
  38. ncbi Upper respiratory tract bacterial carriage in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia
    Kelly Watson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Western Australia, Australia
    Pediatr Infect Dis J 25:782-90. 2006
    Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are associated with otitis media (OM). Indigenous children experience particularly high rates of OM...
  39. pmc The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response
    Elisa Margolis
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    BMC Microbiol 10:59. 2010
    ..disease caused by the normally commensal bacteria Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae is their colonization of the nasal passages...
  40. ncbi Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, CHO 2308, 940 NE 13th Street, Oklahoma City, OK 73104, USA
    Microb Pathog 36:25-33. 2004
    Since Haemophilus influenzae lacks enzymes necessary for synthesis of the porphyrin ring, it has an absolute growth requirement for a porphyrin source...
  41. ncbi The incidence of Streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly Moraxella catarrhalis in a mouse nasal colonisation model
    Ajay Krishnamurthy
    Capricornia Centre for Mucosal Immunology, CQUniversity, Queensland, Australia
    Microbes Infect 11:545-53. 2009
    ..pneumoniae, Moraxella catarrhalis more significantly affected pneumococcal OM than did non-typeable Haemophilus influenzae (p<0.001) by increasing the incidence rate, infection bacterial load and duration of infection...
  42. pmc Use of multiplex PCR for simultaneous detection of four bacterial species in middle ear effusions
    P H Hendolin
    AIV Institute, University of Kuopio, Finland
    J Clin Microbiol 35:2854-8. 1997
    A multiplex PCR procedure was developed for the simultaneous detection of Alloiococcus otitidis, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in middle ear effusions (MEEs) from patients with chronic otitis ..
  43. pmc RNA secondary structure regulates the translation of sxy and competence development in Haemophilus influenzae
    Andrew D S Cameron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Nucleic Acids Res 36:10-20. 2008
    ..gene product is the central regulator of DNA uptake by naturally competent gamma-proteobacteria such as Haemophilus influenzae, Vibrio cholerae and probably Escherichia coli...
  44. pmc Construction of non-polar mutants in Haemophilus influenzae using FLP recombinase technology
    Erin Tracy
    Center for Microbial Pathogenesis in The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    BMC Mol Biol 9:101. 2008
    Nontypeable Haemophilus influenzae (NTHi) is a gram-negative bacterium that causes otitis media in children as well as other infections of the upper and lower respiratory tract in children and adults...
  45. pmc Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
    J N Weiser
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 187:631-40. 1998
    b>Haemophilus influenzae undergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on several invasive pathogens residing in the human respiratory tract...
  46. pmc Microbial interactions during upper respiratory tract infections
    Melinda M Pettigrew
    Yale School of Public Health, New Haven, Connecticut 06520 8034, USA
    Emerg Infect Dis 14:1584-91. 2008
    Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx...
  47. pmc Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease
    Grant A Mackenzie
    Child Health Division, Menzies School of Health Research, Darwin, Australia
    BMC Infect Dis 10:304. 2010
    ..To determine the prevalence of carriage of respiratory bacterial pathogens, and the risk factors for and serotype distribution of pneumococcal carriage in an Australian Aboriginal population...
  48. pmc Lack of expression of the global regulator OxyR in Haemophilus influenzae has a profound effect on growth phenotype
    I Maciver
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235 9048, USA
    Infect Immun 64:4618-29. 1996
    A pBR322-based library of chromosomal DNA from the nontypeable Haemophilus influenzae TN106 was screened for the expression of transferrin-binding activity in Escherichia coli...
  49. ncbi Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media
    Galia Barkai
    Soroka University Medical Center, Beer Sheva, Israel
    Pediatr Infect Dis J 28:466-71. 2009
    Characterization of acute otitis media (AOM) caused by nontypable Haemophilus influenzae (NTHi) is important, particularly in view of the efforts to develop vaccines against NTHi...
  50. pmc Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade
    Stefania Galdiero
    Dipartimento di Chimica Biologica, Università degli Studi di Napoli Federico II and Istituto di Biostrutture e Bioimmagini, CNR, 80134 Naples, Italy
    Infect Immun 71:2798-809. 2003
    ..The P2 porin is the most abundant outer membrane protein of Haemophilus influenzae type b...
  51. pmc Use of the riboflavin synthase gene (ribC) as a model for development of an essential gene disruption and complementation system for Haemophilus influenzae
    Amna Saeed-Kothe
    Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
    Appl Environ Microbiol 70:4136-43. 2004
    We have developed a system for rapid and reliable assessment of gene essentiality in Haemophilus influenzae Rd strain KW20...
  52. pmc Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae
    Bjorn Vergauwen
    Laboratory for Protein Biochemistry and Protein Engineering, Ghent University, Belgium
    J Bacteriol 185:1572-81. 2003
    ..g., the Ahp system characteristic or enteric bacteria) is apparent from the Haemophilus influenzae Rd genome sequence, suggesting that the organism relies on alternative systems to maintain redox ..
  53. pmc Delineation of the species Haemophilus influenzae by phenotype, multilocus sequence phylogeny, and detection of marker genes
    Niels Nørskov-Lauritsen
    Department of Clinical Microbiology, Aarhus University Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    J Bacteriol 191:822-31. 2009
    ..more information on the much-debated definition of prokaryotic species, we investigated the borders of Haemophilus influenzae by comparative analysis of H...
  54. ncbi Survival of nontypeable Haemophilus influenzae in macrophages
    J E Craig
    University of Manchester, School of Biological Sciences, 1.800, Stopford Building, Manchester M13 9PT, UK
    FEMS Microbiol Lett 203:55-61. 2001
    In this study we have investigated the ability of nonencapsulated, nontypeable Haemophilus influenzae, NT477 to survive in the J774 mouse macrophage-like cell line. Viable, intracellular nontypeable H...
  55. ncbi Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008
    Jessica R MacNeil
    Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 53:1230-6. 2011
    With the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines, there has been a dramatic reduction of Hib disease in young children and the epidemiological trends of invasive H. influenzae have shifted.
  56. pmc Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae
    Samantha W Sharpe
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, Columbus, OH 43205, USA
    Infect Immun 79:4361-9. 2011
    ..Nontypeable Haemophilus influenzae (NTHI), an opportunistic pathogen of the upper and lower respiratory tracts, produces OMVs in vivo, but ..
  57. pmc A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    BMC Res Notes 5:327. 2012
    b>Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient.
  58. ncbi Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity
    Diana Barthel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    J Immunol 188:379-85. 2012
    ..we characterize binding of this important coagulation regulator to the respiratory pathogen nontypeable Haemophilus influenzae and identify the Haemophilus surface protein E (PE) as a new plasminogen-binding protein...
  59. pmc Redox signal transduction by the ArcB sensor kinase of Haemophilus influenzae lacking the PAS domain
    D Georgellis
    Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico City, Mexico
    J Bacteriol 183:7206-12. 2001
    ..We demonstrate that the arcA and arcB genes of Haemophilus influenzae specify a two-component system...
  60. ncbi Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule
    Selma P Wiertsema
    School of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, WA 6009, Perth, Australia
    Vaccine 29:5163-70. 2011
    ..We found that 2-4 years after introduction of PCV7 in the National Immunisation Program, nontypeable Haemophilus influenzae (NTHi) was the predominant pathogen isolated from the nasopharynx and middle ear of children with a ..
  61. ncbi Multiple combination antibiotic susceptibility testing of nontypeable Haemophilus influenzae biofilms
    Robert Slinger
    Department of Pediatrics, Ottawa, Ontario, Canada K1H 8L1
    Diagn Microbiol Infect Dis 56:247-53. 2006
    b>Haemophilus influenzae is a cause of otitis media with effusion (OME). Animal models demonstrate growth of H. influenzae biofilms in OME, which may explain why OME does not respond well to conventional antibiotic therapy...
  62. pmc Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays
    Michael J Binks
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    PLoS ONE 7:e34083. 2012
    Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology...
  63. ncbi Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice
    Norimitsu Tanaka
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Vaccine 25:2680-7. 2007
    ..PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae, and anti-PC immune responses are known to protect mice against invasive bacterial diseases...
  64. ncbi Detailed structural features of lipopolysaccharide glycoforms in nontypeable Haemophilus influenzae strain 2019
    Mikael K R Engskog
    Clinical Research Centre, University College of South Stockholm, Karolinska Institutet, Stockholm, Novum, S 141 86 Huddinge, Sweden
    Carbohydr Res 346:1241-9. 2011
    We have investigated the structure of the lipopolysaccharide (LPS) of nontypeable Haemophilus influenzae (NTHi) strain 2019, a prototype strain that is used for studies of NTHi biology and disease...
  65. ncbi Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial
    Elske J M van Gils
    Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    Vaccine 29:7595-8. 2011
    ..of Streptococcus pneumoniae and of other nasopharyngeal commensals and well-known otitis media pathogens, Haemophilus influenzae and Moraxella catarrhalis, in children...
  66. pmc Survival of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis frozen in skim milk- tryptone-glucose-glycerol medium
    Tarja Kaijalainen
    KTL, National Public Health Institute, Oulu, Helsinki, Finland
    J Clin Microbiol 42:412-4. 2004
    In STGG (skim milk, tryptone, glucose, glycerol) medium at -80 degrees C, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates survived for at least 3 years, and the same species have survived in ..
  67. ncbi Extensive variation in natural competence in Haemophilus influenzae
    Heather Maughan
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Evolution 63:1852-66. 2009
    ..These results show that strains can differ considerably in the amount of DNA they take up and recombine, indicating that the benefit associated with competence is likely to vary in space and/or time...
  68. ncbi The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane protein
    Takashi Hirano
    Department of Otolaryngology, Faculty of Medicine, Oita University, Hasama machi, Oita 8795593, Japan
    Int J Pediatr Otorhinolaryngol 73:1657-65. 2009
    Acute otitis media (AOM) is one of the most common infectious diseases in children. Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen in AOM...
  69. pmc Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae
    L A Novotny
    The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, Columbus, Ohio, USA
    Mucosal Immunol 4:456-67. 2011
    We have developed three nontypeable Haemophilus influenzae (NTHI) adhesin-derived immunogens that are significantly efficacious against experimental otitis media (OM) due to NTHI when delivered parenterally...
  70. ncbi Respiratory infections caused by non-typeable Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Curr Opin Infect Dis 16:129-34. 2003
    This review will consider recent developments in the clinical aspects of infections due to non-typeable Haemophilus influenzae. In addition, newer developments in the areas of mechanisms of pathogenesis, host pathogen interaction, immune ..
  71. pmc Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin
    Viveka Schaar
    Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skane University Hospital, Malmo, Sweden
    Antimicrob Agents Chemother 55:3845-53. 2011
    ..The bacterial species is often isolated together with Streptococcus pneumoniae and Haemophilus influenzae. Outer membrane vesicles (OMVs) are released by M...
  72. pmc Nanoscale structural and mechanical properties of nontypeable Haemophilus influenzae biofilms
    Fernando Teran Arce
    Center for Nanomedicine, Department of Medicine Pulmonary and Critical Care Section, University of Chicago, 5841 S Maryland Ave, I 505, Chicago, IL 60637, USA
    J Bacteriol 191:2512-20. 2009
    Nontypeable Haemophilus influenzae (NTHI) bacteria are commensals in the human nasopharynx, as well as pathogens associated with a spectrum of acute and chronic infections...
  73. pmc Real-time PCR for determining capsular serotypes of Haemophilus influenzae
    Younes Maaroufi
    Department of Microbiology and Infectious Diseases, Institut Jules Bordet, Rue Heger Bordet 1, 1000 Brussels, Belgium
    J Clin Microbiol 45:2305-8. 2007
    A two-step real-time PCR assay targeting all six capsulation loci of Haemophilus influenzae (i.e., serotypes a to f) was developed and compared with a previously published qualitative PCR assay by using 131 H. influenzae clinical isolates...
  74. pmc Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
    George G Zhanel
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Antimicrob Agents Chemother 47:1875-81. 2003
    A total of 7,566 unique patient isolates of Haemophilus influenzae and 2,314 unique patient isolates of Moraxella catarrhalis were collected between October 1997 and June 2002 from 25 medical centers in 9 of the 10 Canadian provinces...
  75. pmc Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 189:8300-7. 2007
    Nontypeable Haemophilus influenzae (NTHI) causes chronic infections that feature the formation of biofilm communities...
  76. ncbi Adaptive immunity to nontypeable Haemophilus influenzae
    Paul T King
    Department of Respiratory Medicine, Monash Medical Centre, Monash University, Melbourne
    Am J Respir Crit Care Med 167:587-92. 2003
    Nontypeable Haemophilus influenzae (NTHi) colonizes the upper respiratory tract of most healthy people and is also a major cause of infection in chronic obstructive lung disease...
  77. pmc Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
    L O Bakaletz
    Division of Otologic Research, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Infect Immun 67:2746-62. 1999
    ..protocol, were conducted to initially screen and ultimately more fully assess several nontypeable Haemophilus influenzae outer membrane proteins or their derivatives for their relative protective efficacy in chinchilla models ..
  78. ncbi Acute otitis media caused by Moraxella catarrhalis: epidemiologic and clinical characteristics
    Arnon Broides
    Pediatric Immunology Clinic, Pediatric Emergency Department, Soroka University Medical Center, Beer Sheva, Israel
    Clin Infect Dis 49:1641-7. 2009
    ..This study describes the epidemiologic, microbiologic, and otologic features and selected signs and symptoms of acute otitis media (AOM) caused by Moraxella catarrhalis and compares them with AOM caused by other bacterial pathogens...
  79. pmc ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae
    Sandy M S Wong
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Ave N, S6 242, Worcester, MA 01655, USA
    Infect Immun 79:1971-83. 2011
    Signaling mechanisms used by Haemophilus influenzae to adapt to conditions it encounters during stages of infection and pathogenesis are not well understood...
  80. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
    ..Our data thus indicate that CYLD acts as a negative regulator for NF-kappaB-dependent inflammation in vivo, hence protecting the host against detrimental inflammatory response to NTHi infection...
  81. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    Nontypeable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract infections, including otitis media and bronchitis...
  82. pmc Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus
    Dayle A Daines
    Lawrence Livermore National Laboratory, L 501, 7000 East Avenue, Livermore CA 94550 9698, USA
    BMC Microbiol 4:30. 2004
    Certain strains of an obligate parasite of the human upper respiratory tract, nontypeable Haemophilus influenzae (NTHi), can cause invasive diseases such as septicemia and meningitis, as well as chronic mucosal infections such as otitis ..
  83. ncbi Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis
    V Bandi
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Respir Crit Care Med 164:2114-9. 2001
    The frequency of colonization and intracellular localization of nontypeable Haemophilus influenzae (NTHi) in the lower respiratory tract was determined in healthy adults and in clinically stable and acutely ill chronic bronchitis (CB) ..
  84. pmc Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media
    Kevin M Mason
    Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus 43205, USA
    Infect Immun 71:3454-62. 2003
    The gram-negative bacterium nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic otitis media with effusion and, with Streptococcus pneumoniae and Moraxella catarrhalis, is a causative agent of acute otitis ..
  85. pmc Augmented lung inflammation protects against influenza A pneumonia
    Michael J Tuvim
    Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e4176. 2009
    ..We sought to determine whether lung inflammation promoted or impaired host survival in influenza pneumonia...
  86. pmc Nontypeable Haemophilus influenzae clearance by alveolar macrophages is impaired by exposure to cigarette smoke
    Pau Martí-Lliteras
    Programa de Infección e Inmunidad, Fundación Caubet CIMERA, Recinto Hospital Joan March, Bunyola, Spain
    Infect Immun 77:4232-42. 2009
    Nontypeable Haemophilus influenzae (NTHI) is an opportunistic gram-negative pathogen that causes respiratory infections and is associated with progression of respiratory diseases...
  87. ncbi Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior
    Alice L Erwin
    Microbial Pathogens Program, Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
    Trends Microbiol 15:355-62. 2007
    b>Haemophilus influenzae is genetically diverse and exists as a near-ubiquitous human commensal or as a pathogen. Invasive type b disease has been almost eliminated in developed countries; however, unencapsulated strains - nontypeable H...
  88. ncbi Exploitation of host epithelial signaling networks by respiratory bacterial pathogens
    Jian dong Li
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 900057, USA
    J Pharmacol Sci 91:1-7. 2003
    Although tremendous effort has been put towards identifying the surface molecules of nontypeable Haemophilus influenzae (NTHi) for vaccine development over the past decades, it is only recently that we have begun to appreciate the ..
  89. pmc Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens
    J S Kroll
    Molecular Infectious Diseases Group, Imperial College School of Medicine, Department of Paediatrics, St Mary s Hospital, Norfolk Place, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 95:12381-5. 1998
    ....
  90. ncbi Molecular and cellular determinants of non-typeable Haemophilus influenzae adherence and invasion
    Joseph W St Geme
    Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63117, USA
    Cell Microbiol 4:191-200. 2002
    Non-typeable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract...
  91. ncbi The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons > or = 65 years old
    Mark S Dworkin
    Division of Infectious Diseases, Illinois Department of Public Health, Chicago, IL 60612, USA
    Clin Infect Dis 44:810-6. 2007
    Few studies have reported the epidemiological characteristics of Haemophilus influenzae disease among adults.
  92. pmc TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media
    Anke Leichtle
    Department of Surgery Otolaryngology, University of California San Diego, La Jolla, California 92093, USA
    Innate Immun 15:205-15. 2009
    ..We investigated the inflammatory response to nontypeable Haemophilus influenzae using a model of otitis media in wild-type, TLR2(- /-) and TLR4(-/ -) mice by gene microarray, qPCR, ..
  93. ncbi Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways
    Ran Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, CA 90057, USA
    Biochem Biophys Res Commun 324:1087-94. 2004
    Mucin overproduction is a hallmark of nontypeable Haemophilus influenzae (NTHi) infections. The molecular mechanisms underlying up-regulation of mucin in NTHi infections especially during the initial phase remain unknown...
  94. pmc Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae
    J N Weiser
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104 4318, USA
    Infect Immun 65:943-50. 1997
    Choline, although not a nutritional requirement for Haemophilus influenzae, is taken up from the growth medium and incorporated into its lipopolysaccharide (LPS)...
  95. pmc Simple sequence repeats in Haemophilus influenzae
    Peter M Power
    Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DS, UK
    Infect Genet Evol 9:216-28. 2009
    ..repeat (SSRs) of DNA are subject to high rates of mutation and are important mediators of adaptation in Haemophilus influenzae. Previous studies of the Rd KW20 genome identified the primacy of tetranucleotide SSRs in mediating phase ..
  96. ncbi The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract
    Joseph A Jurcisek
    Columbus Children s Research Institute, The Ohio State University College of Medicine, Department of Pediatrics, Center for Microbial Pathogenesis, Columbus, OH 43205, USA
    Mol Microbiol 65:1288-99. 2007
    We recently described the expression of type IV pili (Tfp) by non-typeable Haemophilus influenzae (NTHI), a common respiratory tract pathogen...
  97. ncbi Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease
    Sanjay Sethi
    Department of Medicine, University of Buffalo SUNY and the Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 169:448-53. 2004
    Previous studies of immune response to Haemophilus influenzae after exacerbations of chronic obstructive pulmonary disease (COPD) have yielded contradictory results...
  98. pmc Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study
    Joost A M Labout
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    Eur J Epidemiol 26:61-6. 2011
    ..the second year of life with special emphasis on the role of colonization with Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. The study was embedded in the Generation R Study...
  99. pmc Oral non-typable Haemophilus influenzae enhances physiological mechanism of airways protection
    R L Clancy
    School of Biomedical Sciences, Faculty of Health, University of Newcastle, Immunology, Hunter Area Pathology Service, HNEHS, John Hunter Hospital, Newcastle, NSW, Australia
    Clin Exp Immunol 161:127-33. 2010
    Oral immunotherapy with inactivated non-typeable Haemophilus influenzae (NTHi) prevents exacerbations of chronic obstructive pulmonary disease, but the mechanism is unclear...
  100. pmc Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function
    Kevin M Mason
    The Research Institute at Nationwide Children s Hospital, The Ohio State University College of Medicine, Department of Pediatrics, Center for Microbial Pathogenesis, Columbus, OH 43205, USA
    J Bacteriol 193:2527-35. 2011
    ..Previously, we showed that Sap translocator function is necessary for nontypeable Haemophilus influenzae (NTHI) behaviors that mediate diseases of the human airway...
  101. ncbi The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae
    Yukiko Matsue
    Biotechnology Research Center, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Antibiot (Tokyo) 63:583-8. 2010
    ..we found that a herbicide, ketoclomazone, exhibited antibacterial activity against a pathogenic bacterium, Haemophilus influenzae, with an MIC value of 12...

Research Grants66

  1. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..b>Haemophilus influenzae provides a genetically tractable model to examine this aspect of pathogenesis. H...
  2. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..In Aim 3, we will establish in vitro bacterial biofilms with nontypeable Haemophilus influenzae (NTHi) or with Streptococcus pneumoniae (pneumococcus) and determine the viral replication potential in ..
  3. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Moreover, the epidemiology of childhood pneumonia is changing due to the impact of Haemophilus influenzae type b (Hib) vaccine and pneumococcal conjugate vaccine, and the emergence of non-vaccine serotypes of ..
  4. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..aeruginosa, Haemophilus influenzae) and Gram-positive (Staphylococcus aureus) organisms and in two genetic backgrounds (C57BL/6 and129S6)...
  5. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  6. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..e. during colonization) at the level of the molecular crosstalk that occurs between nontypeable Haemophilus influenzae (NTHI) and the mucosal epithelium of the NP;2) the polymicrobial disease OM (i.e...
  7. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ABSTRACT Current vaccines against Haemophilus influenzae type b have reduced the incidence of H. influenzae type b invasive diseases...
  8. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..recent advances in our understanding of the pathogenesis of otitis media (OM) due to nontypeable Haemophilus influenzae (NTHI)...
  9. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..meningitidis, Listeria monocytogenes, Haemophilus influenzae). We are requesting funding for a ...
  10. Structures of RNA processing and Silencing Enzymes in Prokaryotes
    Hong Li; Fiscal Year: 2013
    ..medically important bacteria that include but not limited to Yersinia pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, Salmonella Typhi ..
  11. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..release kinetics of our new materials and to injection mold TTs, 2) to confirm our in vitro studies with Haemophilus influenzae and Streptococcus pneumoniae, and quantify synergy and monitor for the development of resistant strains, 3)..
  12. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..metapneumovirus, human rhinovirus A/B/C, human bocavirus 1/2/3/4, human parainfluenza virus 1/2/3/4, Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and ..
  13. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nontypeable Haemophilus influenzae (NTHi) commonly colonize the mucosal surfaces of the human upper respiratory tract...
  14. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nontypable Haemophilus influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, pneumonia, and exacerbations of chronic lung disease...
  15. H. influenzae: Role of Sialic Acid in Virulence
    Michael Apicella; Fiscal Year: 2009
    Project Summary/Abstract: Nontypeable Haemophilus influenzae (NTHi) commonly colonize the mucosal surfaces of the human upper respiratory tract...
  16. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    ..pneumoniae, the relative proportion of cases of OM due to our studied microorganism (nontypeable Haemophilus influenzae or NTHI) has increased significantly...
  17. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    Project Summary/Abstract The bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  18. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen as it is a major cause of otitis media (OM), sinusitis, exacerbations of chronic obstructive pulmonary disease (COPD) and ..
  19. Genetics &Biology of M. catarrhalis LOS in Otitis Media
    Anthony A Campagnari; Fiscal Year: 2013
    ..e. Neisseria meningitidis, N. gonorrhoeae and Haemophilus influenzae. More importantly, these common carbohydrate epitopes are involved in virulence, i.e...
  20. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..and innate immune response deficits among otitis prone (OP) children to infections caused by nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (Spn)...
  21. Innate and adaptive immune responses at the respiratory mucosa
    Yasmin Thanavala; Fiscal Year: 2010
    ..immune responses in the lung using mouse adapted respiratory syncytial virus (RSV) and non-typeable Haemophilus influenzae (NTHI) a gram negative bacterium...
  22. Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis Diagnos
    Xiujun Li; Fiscal Year: 2013
    ..diagnosis of three different types of bacterial meningitis, namely Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumonia especially for resource-poor settings...
  23. Regulation of Inflammation by EGFR in Otitis Media
    Xiangbin Xu; Fiscal Year: 2012
    ..Inflammation in the middle ear caused by microorganisms is a hallmark of OM. Nontypeable Haemophilus influenzae (NTHi) is an important human pathogen that causes OM...
  24. PROTEIN/LIPID INTERACTIONS
    Robert B Gennis; Fiscal Year: 2013
    ..focus on 1) Mycobacterium tuberculosis, which requires cytochrome bd in the persistent (dormant) state;2) Haemophilus influenzae, for which cytochrome bd has been recently shown to be essential for growth;and 3) Neisseria gonorrhoeae, ..
  25. Laser-based powder vaccine delivery for improved newborn immunization
    Xinyuan Chen; Fiscal Year: 2013
    ..Polysaccharide-encapsulated bacteria, such as Haemophilus influenzae type b (Hib), are leading causes of serious infections in infants...
  26. The extent and limits of natural transformation in Haemophilus influenzae
    Joshua Chang Mell; Fiscal Year: 2013
    ..One of these pathogens, Haemophilus influenzae, inhabits the upper respiratory tract of most people, usually with no negative effect, but can cause ..
  27. Innate and adaptive immune response to bacterial infections in COPD patients
    Yasmin Thanavala; Fiscal Year: 2009
    ..tree is sterile, however in COPD patients it is chronically colonized, predominantly with nontypeable Haemophilus influenzae (NTHI), Moraxella catarrhalis and Streptococcus pneumoniae...
  28. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    ..pneumoniae vaccination emphasizes the clinical importance of nontypeable Haemophilus influenzae (NTHi), which is the focus of this proposal...
  29. IgA Protease as Therapy to Reverse IgA Nephropathy
    Jiazhou Qiu; Fiscal Year: 2012
    ..We will develop IgA protease of Haemophilus influenzae as an injectable biological therapeutic for this purpose...
  30. Airway Metalloproteinases in Mucosal Immunity
    CAROLE LYNN WILSON; Fiscal Year: 2010
    ..Infection of the lung by various pathogens (e.g., Staphylococcus aureus, haemophilus influenzae, Pseudomonas aeruginosa, and other) are a major cause of community-acquired infection and morbidity and ..
  31. Persistent H. influenzae in COPD - virulence, vaccines and antibiotic resistance
    Timothy F Murphy; Fiscal Year: 2013
    ..begun to elucidate the critical role of bacterial colonization and infection, particularly by nontypeable Haemophilus influenzae (NTHI), in the course and pathogenesis of COPD...
  32. A New Antibacterial Drug Target: Analyzing Inhibitor Binding to a Bacterial Metal
    Richard C Holz; Fiscal Year: 2010
    ..3 E resolution structures of the mono and dinuclear Zn(II) DapE enzymes from the pathogenic bacterium Haemophilus influenzae. These structures provide the foundation needed to examine the binding of several new, potent inhibitors ..
  33. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..for its ability to protect mice against systemic and local Klebsiella pneumoniae, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis and Salmonella typhimurium infections...
  34. Metabolic regulation in otitis media
    DAYLE ANITA DAINES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Nonencapsulated (nontypeable) Haemophilus influenzae (NTHi) are human-adapted commensal organisms that can also cause chronic mucosal infections, particularly otitis media...
  35. Development of a vaccine for prevention of Haemophilus influenzae otitis media
    Stephen J Barenkamp; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media and other illnesses caused by nontypeable Haemophilus influenzae (NTHi) remain significant health problems for children and a vaccine for prevention of disease is much needed...
  36. Effect of Haemophilus influenzae infection on lung CD8+ T cells in COPD
    CHRISTINE M BASMAJIAN; Fiscal Year: 2013
    ..TLR2/1 is known to recognize the outer membrane protein of nontypeable Haemophilus influenzae (NTHI), one of the predominant bacterial pathogens associated with airway infection in COPD, both in ..
  37. EMERGING INFECTIONS PROGRAM
    Paul R Cieslak; Fiscal Year: 2011
    ..invasive infectionby bacterialpathogens, includinggroups A and B streptococci,Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis,and for methicillin-resistantStaphylococcusaureus;for entericand foodborne ..
  38. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..and aminoglycoside-resistant Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, and Haemophilus influenzae clinical isolates, among many others, in nanomolar or low micromolar concentrations...
  39. Microbial interactions in otitis media
    WILLIAM E SWORDS; Fiscal Year: 2013
    PROJECT SUMMARY This project aims to define how polymicrobial infection influences bacterial otitis media. Haemophilus influenzae (Hi), Streptococcus pneumoniae (Sp), and Moraxella catarrhalis (Mcat) are the predominant isolates from ..
  40. Bacterial biofilms in otitis media
    WILLIAM E SWORDS; Fiscal Year: 2013
    ..Otitis media is caused by airway opportunists such as Haemophilus influenzae (Hi, which forms biofilm communities that promote bacterial persistence within the middle-ear chamber...
  41. Quorum signal eavesdropping by Moraxella catarrhalis
    WILLIAM E SWORDS; Fiscal Year: 2013
    ..infections, and our data show that Mcat can sense dihydroxypentanedione (DPD) quorum signals produced by Haemophilus influenzae. We hypothesize that Mcat "eavesdrops" on quorum signal molecules produced by other pathogens, resulting ..
  42. DEVELOPMENT OF A FIMBRIN VACCINE AGAINST OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 1999
    ..the pathogenesis of and immune response directed against one of the primary causative agents, nontypeable Haemophilus influenzae (NTHi), is poorly understood and a vaccine is not available...
  43. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2002
    Nontypable Haemophilus influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, bronchitis, and pneumonia...
  44. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2004
    ..The strategy will incorporate features of the highly successful Haemophilus influenzae type b and pertussis vaccines that utilize defined surface virulence determinants, colonization factors, ..
  45. DNA SEQUENCE OF STAPHYLOCOCCUS AUREUS 8325 GENOME
    JOHN LANDOLO; Fiscal Year: 1999
    In 1995, Fleischman et al. (40) determined the nucleotide sequence of Haemophilus influenzae Rd without prior restriction site mapping and cosmid cloning...
  46. Genomic Sequence of an Otitis Media Isolate of NTHi
    Robert Munson; Fiscal Year: 2003
    At the current time, we have a poor understanding of how nontypeable Haemophilus influenzae (NTHi) cause otitis media (OM) in children...
  47. EPITHELIAL CELL RESPONSE TO H.INFLUENZAE IN THE AIRWAY
    Dwight Look; Fiscal Year: 2003
    ..g., airway inflammation in cystic fibrosis). This proposal focuses on Haemophilus influenzae, which frequently colonizes human respiratory mucosa and often produces respiratory tract disease, ..
  48. Decision Analysis of Otitis Media Vaccination Strategies
    Tracy Lieu; Fiscal Year: 2005
    ..These include new or improved vaccines against non-typeable Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and respiratory syncytial virus...
  49. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    ..Initial infection by bacterial pathogens including non-typeable Haemophilus influenzae (NTHi) is believed to contribute to most otitis media...
  50. THE EFFICACY OF CONJUGATE VACCINES AGAINST H INFLUENZAE
    Eugene Shapiro; Fiscal Year: 1993
    b>Haemophilus influenzae type b is the most common cause of bacterial meningitis and other serious invasive bacterial infections in children...
  51. Role of Spiral Ligament Fibrocytes in Inner Ear Inflammation
    Sung K Moon; Fiscal Year: 2010
    ..Nontypeable Haemophilus influenzae (NTHI) is the model organism for inducing inner ear inflammation, which is one of the major OM pathogens...
  52. HAEMOPHILUS--RAMIFICATIONS OF PILUS MEDIATED ADHERENCE
    GRAHAM KRASAN; Fiscal Year: 2004
    b>Haemophilus influenzae is a pathogen that mediates a wide range of human disease including otitis media, sinusitis, and pneumonia often in association with an increased density of nasopharyngeal colonization...
  53. LIPOOLIGOSACCHARIDES OF HAEMOPHILUS INFLUENZAE
    Michael Apicella; Fiscal Year: 2003
    The lipooligosaccharides of Haemophilus influenzae are important virulence factors. The lipid A portion of the lipooligosaccharide (LOS) is responsible in part for the toxicity associated with this organism...
  54. INTERACTION OF COMPLEMENT AND HAEMOPHILUS INFLUENZAE
    K Cates; Fiscal Year: 1991
    ..Because children have little specific antibody, the alternative pathway is crucial for their protection. Haemophilus influenzae type b (Hib), the most common cause of bacterial meningitis in children, is resistant to alternative ..
  55. GENETIC CONTROL OF ANTIBODY RESPONSES TO POLYSACCHARIDES
    Dan Granoff; Fiscal Year: 1993
    ..Aim 1, we will investigate the immunologic and genetic basis of "vaccine failure" in patients who develop Haemophilus influenzae type b (Hib) disease despite previous vaccination with Hib polysaccharide (PS) vaccine...
  56. GENETICS OF H. AEGYPTIUS BRAZILIAN PURPURIC FEVER CLONE
    Luis Actis; Fiscal Year: 2000
    Brazilian purpuric fever (BPF) is a fatal disease caused by a unique invasive clone of Haemophilus influenzae biogroup aegyptius (H. aegyptius), a bacterial species that is normally non-invasive and causes mild cases of conjunctivitis...
  57. HEME ACQUISITION BY HAEMOPHILUS INFLUENZAE
    Eric Hansen; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): A striking feature of the biology of Haemophilus influenzae is that these organisms can be distinguished from nearly all other facultative, gram-negative bacteria by their absolute ..
  58. PROPHOLAXIS OF H. INFLUENZAE AND OTHER INFECTIONS
    Mathuram Santosham; Fiscal Year: 1991
    ..the safety and efficacy of passive immunization with a human hyperimmune globulin (BPIG) in preventing Haemophilus influenzae (HI) and other infections...
  59. Haemophilus influenzae iron/heme regulon
    Terrence Stull; Fiscal Year: 2007
    Current vaccines against Haemophilus influenzae type b have reduced the incidence of H. influenzae type b invasive diseases...
  60. GENETIC ANALYSIS OF H. INFLUENZAE CAPSULE EXPRESSION
    SUSAN HOISETH; Fiscal Year: 1992
    The Haemophilus influenzae type b capsule has long been recognized as an important virulence determinant. Capsule expression, however, is genetically unstable, and capsule-deficient mutants arise at frequencies of 0.1 to 0.5%...
  61. Role of sialylated LPS in H. influenzae otitis media
    Richard Goldstein; Fiscal Year: 2003
    Nontypable Haemophilus influenzae (NTHi) is a major cause of acute otitis media (AOM) accounting for 20-30% of all episodes. There is also evidence that NTHi is the most frequent pathogen in children with recurrent episodes of AOM...
  62. HAEMOPHILUS INFLUENZAE B CONJUGATE VACCINE EFFICACY
    Joel Ward; Fiscal Year: 1993
    ..objective of this proposal is to assess by case-control methods the protective efficacy characteristics of Haemophilus influenzae type b (Hib) conjugate vaccines to be licensed by 1991 for routine immunization of infants 2 to 6 months ..
  63. Structure-Function of Entamoeba Alcohol Dehydrogenase 2
    Samuel Stanley; Fiscal Year: 2005
    Nontypeable Haemophilus influenzae (NTHi) causes infections in chronic obstructive pulmonary disease (COPD) and otitis media (OM). Both are characterized by inflammation...
  64. HAEMOPHILUS INFLUENZAE PATHOGENESIS--ACQUISTION OF IRON
    Terrence Stull; Fiscal Year: 1990
    ....
  65. Virulence genes Haemophilus influenzae
    Arnold Smith; Fiscal Year: 2004
    b>Haemophilus influenzae is a human-restricted bacterium which can exist as an upper respiratory commensal, but also cause focal and/or systemic disease...
  66. Viral-Bacterial Interactions in the Airway Epithelium
    Raymond Pickles; Fiscal Year: 2006
    ..RSV) and parainfluenza virus (PIV) have been associated with bacterial pathogens such as non-typified Haemophilus influenzae (NTHi)...