listeria monocytogenes

Summary

Summary: A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.

Top Publications

  1. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
  2. pmc Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 108:19484-91. 2011
  3. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
  4. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
  5. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
  6. pmc The role of anorexia in resistance and tolerance to infections in Drosophila
    Janelle S Ayres
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Biol 7:e1000150. 2009
  7. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
  8. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
  9. pmc c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response
    Joshua J Woodward
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA
    Science 328:1703-5. 2010
  10. ncbi A trans-acting riboswitch controls expression of the virulence regulator PrfA in Listeria monocytogenes
    Edmund Loh
    Department of Molecular Biology, Umea University, 90187 Umea, Sweden
    Cell 139:770-9. 2009

Detail Information

Publications327 found, 100 shown here

  1. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  2. pmc Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 108:19484-91. 2011
    b>Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the analysis of both its saprophytic life and infectious process, new concepts in microbiology, cell biology, and pathogenesis have been discovered...
  3. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice...
  4. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  5. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..TLR5-stimulating activity was purified from Listeria monocytogenes culture supernatants and identified as flagellin by tandem mass spectrometry. Expression of L...
  6. pmc The role of anorexia in resistance and tolerance to infections in Drosophila
    Janelle S Ayres
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Biol 7:e1000150. 2009
    ..increasing the fly's tolerance to Salmonella typhimurium infections while decreasing resistance to Listeria monocytogenes. This suggests that attempts to extend lifespan through diet restriction or the manipulation of pathways ..
  7. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii.
  8. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  9. pmc c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response
    Joshua J Woodward
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA
    Science 328:1703-5. 2010
    Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells. Induction of this host response is often dependent on microbial secretion systems and, in L...
  10. ncbi A trans-acting riboswitch controls expression of the virulence regulator PrfA in Listeria monocytogenes
    Edmund Loh
    Department of Molecular Biology, Umea University, 90187 Umea, Sweden
    Cell 139:770-9. 2009
    ..SAM) riboswitches, SreA and SreB, can also function in trans and act as noncoding RNAs in Listeria monocytogenes. SreA and SreB control expression of the virulence regulator PrfA by binding to the 5'-untranslated region ..
  11. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  12. ncbi Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    C S Hsieh
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 260:547-9. 1993
    ..of naïve, ovalbumin-specific alpha beta T cell receptor transgenic T cell, it was found that heat-killed Listeria monocytogenes induced TH1 development in vitro through macrophage production of interleukin-12 (IL-12)...
  13. pmc Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
    Alexey Popov
    Molecular Tumor Biology and Tumor Immunology at the Clinic I for Internal Medicine, University of Cologne, Cologne, Germany
    J Clin Invest 116:3160-70. 2006
    ..Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as ..
  14. ncbi Carbon metabolism of intracellular bacterial pathogens and possible links to virulence
    Wolfgang Eisenreich
    Lehrstuhl für Biochemie, Technische Universitat Munchen, D 85747 Garching, Germany
    Nat Rev Microbiol 8:401-12. 2010
    ..Furthermore, we highlight the possible links between intracellular carbon metabolism and the expression of virulence genes...
  15. ncbi The Listeria transcriptional landscape from saprophytism to virulence
    Alejandro Toledo-Arana
    Institut Pasteur, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 459:950-6. 2009
    The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis...
  16. pmc The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    John Demian Sauer
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Infect Immun 79:688-94. 2011
    ..In addition, a recent study demonstrated that the intracellular bacterial pathogen Listeria monocytogenes stimulates a type I IFN response due to cytosolic detection of bacterially secreted c-di-AMP...
  17. ncbi Extending the host range of Listeria monocytogenes by rational protein design
    Thomas Wollert
    Molecular Host Pathogen Interactions, Division of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Cell 129:891-902. 2007
    ..We have emulated this chance occurrence by extending the host range accessible to the human pathogen Listeria monocytogenes by the intestinal route to include the mouse...
  18. pmc Deep RNA sequencing of L. monocytogenes reveals overlapping and extensive stationary phase and sigma B-dependent transcriptomes, including multiple highly transcribed noncoding RNAs
    Haley F Oliver
    Department of Food Science, Cornell University, Ithaca, NY, USA
    BMC Genomics 10:641. 2009
    ..transcriptome, including many sigmaB-dependent genes, was defined for the human bacterial pathogen Listeria monocytogenes using RNA sequencing (RNA-Seq) with the Illumina Genome Analyzer...
  19. pmc Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    Sarah E Warren
    Department of Immunology, University of Washington, Seattle WA 98195, USA
    J Immunol 180:7558-64. 2008
    b>Listeria monocytogenes escapes from the phagosome of macrophages and replicates within the cytosolic compartment. The macrophage responds to L...
  20. pmc Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors
    Peter Lauer
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    J Bacteriol 184:4177-86. 2002
    ..with two different chromosomal bacteriophage integration sites to facilitate strain construction in Listeria monocytogenes. The first vector, pPL1, utilizes the listeriophage U153 integrase and attachment site within the comK ..
  21. pmc Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection
    Vladimir P Badovinac
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Immunity 26:827-41. 2007
    ..These data strongly suggest that modeling the endogenous T cell response with TCR-tg cells will require every effort to approximate the endogenous precursor frequency...
  22. pmc Galleria mellonella as a model system for studying Listeria pathogenesis
    Krishnendu Mukherjee
    Institute for Phytopathology and Applied Zoology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Appl Environ Microbiol 76:310-7. 2010
    ..between pathogenic and nonpathogenic Listeria strains and even between virulent and attenuated Listeria monocytogenes strains...
  23. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection...
  24. pmc Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin
    Georgios Nikitas
    Microbes and Host Barriers Group, French National Reference Center and World Health Organization Collaborating Center on Listeria, Institut Pasteur, Paris, France
    J Exp Med 208:2263-77. 2011
    b>Listeria monocytogenes (Lm) is a foodborne pathogen that crosses the intestinal barrier upon interaction between its surface protein InlA and its species-specific host receptor E-cadherin (Ecad)...
  25. pmc Virulent bacteriophage for efficient biocontrol of Listeria monocytogenes in ready-to-eat foods
    Susanne Guenther
    Institute of Food Science and Nutrition, ETH Zurich, Schmelzbergstrasse 7, LFV B20, 8092 Zurich, Switzerland
    Appl Environ Microbiol 75:93-100. 2009
    Food-borne Listeria monocytogenes is a serious threat to human health, and new strategies to combat this opportunistic pathogen in foods are needed...
  26. pmc CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 35:236-48. 2011
    ..pathogens, we observed that Batf3(-/-) mice exhibited enhanced resistance to the intracellular bacterium Listeria monocytogenes. In wild-type mice, Listeria organisms, initially located in the splenic marginal zone, migrated to the ..
  27. ncbi Listeriosis: a resurgent foodborne infection
    F Allerberger
    Austrian Agency for Health and Food Safety AGES, Binational Austrian German Listeria Reference Centre, Spargelfeldstrasse 191, Vienna, Austria
    Clin Microbiol Infect 16:16-23. 2010
    b>Listeria monocytogenes is the causative agent of human listeriosis, a potentially fatal foodborne infection...
  28. pmc Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion
    Mickey Pentecost
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 6:e1000900. 2010
    b>Listeria monocytogenes (Lm) uses InlA to invade the tips of the intestinal villi, a location at which cell extrusion generates a transient defect in epithelial polarity that exposes the receptor for InlA, E-cadherin, on the cell surface...
  29. ncbi Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
    This review rather than covering the whole field intends to highlight recent findings on the Listeria monocytogenes infectious process or some Listeria specific traits, place them within the framework of well-established data, and ..
  30. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement ..
  31. ncbi Listeria monocytogenes lineages: Genomics, evolution, ecology, and phenotypic characteristics
    Renato H Orsi
    Department of Food Science, Cornell University, Ithaca, NY, USA
    Int J Med Microbiol 301:79-96. 2011
    b>Listeria monocytogenes consists of at least 4 evolutionary lineages (I, II, III, and IV) with different but overlapping ecological niches. Most L...
  32. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  33. ncbi Listeria monocytogenes ActA-mediated escape from autophagic recognition
    Yuko Yoshikawa
    Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 11:1233-40. 2009
    ..Nevertheless, the bacteria Listeria monocytogenes efficiently escapes autophagy...
  34. pmc Probing the pan-genome of Listeria monocytogenes: new insights into intraspecific niche expansion and genomic diversification
    Xiangyu Deng
    National Center for Food Safety and Technology, Illinois Institute of Technology, Summit, Illinois 60501, USA
    BMC Genomics 11:500. 2010
    ..The species of Listeria monocytogenes, a facultative intracellular pathogen and the causative agent of human listeriosis, consists of at least ..
  35. pmc Invasive and adherent bacterial pathogens co-Opt host clathrin for infection
    Esteban Veiga
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell Host Microbe 2:340-51. 2007
    Infection by the bacterium Listeria monocytogenes depends on host cell clathrin. To determine whether this requirement is widespread, we analyzed infection models using diverse bacteria...
  36. pmc Comparative transcriptomics of pathogenic and non-pathogenic Listeria species
    Omri Wurtzel
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 8:583. 2012
    b>Listeria monocytogenes is a human, food-borne pathogen. Genomic comparisons between L...
  37. ncbi Comprehensive appraisal of the extracellular proteins from a monoderm bacterium: theoretical and empirical exoproteomes of Listeria monocytogenes EGD-e by secretomics
    Mickael Desvaux
    INRA, UR454 Microbiology, Food Quality and Safety Team, Saint Genès Champanelle, France
    J Proteome Res 9:5076-92. 2010
    ..The etiological agent of listeriosis, Listeria monocytogenes, is a Gram-positive facultative intracellular foodborne pathogen, whose ecological niche is the soil and ..
  38. ncbi The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems
    K Fisher
    School of Health, The University of Northampton, Northampton, UK
    J Appl Microbiol 101:1232-40. 2006
    ..To investigate the effectiveness of oils and vapours of lemon (Citrus limon), sweet orange (Citrus sinensis) and bergamot (Citrus bergamia) and their components against a number of common foodborne pathogens...
  39. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
    ..We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships...
  40. pmc Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 187:5293-8. 2011
    b>Listeria monocytogenes is a facultative intracellular bacterium that causes systemic infections in immunocompromised hosts. Early recruitment of myeloid cells, including inflammatory monocytes and neutrophils, to sites of L...
  41. ncbi Regulation of Listeria virulence: PrfA master and commander
    Aitor de las Heras
    Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection and Evolution, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Curr Opin Microbiol 14:118-27. 2011
    b>Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection...
  42. pmc MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    Katharina Brandl
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 204:1891-900. 2007
    b>Listeria monocytogenes is a food-borne bacterial pathogen that causes systemic infection by traversing the intestinal mucosa. Although MyD88-mediated signals are essential for defense against systemic L...
  43. pmc In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection
    Ana Camejo
    IBMC, Instituto de Biologia Molecular e Celular, Group of Molecular Microbiology, Universidade do Porto, Porto, Portugal
    PLoS Pathog 5:e1000449. 2009
    b>Listeria monocytogenes is a human intracellular pathogen able to colonize host tissues after ingestion of contaminated food, causing severe invasive infections...
  44. pmc Identification of Listeria monocytogenes genes contributing to intracellular replication by expression profiling and mutant screening
    Biju Joseph
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Mikrobiologie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Bacteriol 188:556-68. 2006
    A successful transition of Listeria monocytogenes from the extracellular to the intracellular environment requires a precise adaptation response to conditions encountered in the host milieu...
  45. ncbi Cell biology and immunology of Listeria monocytogenes infections: novel insights
    Fabrizia Stavru
    Unité des Interactions Bactéries Cellules, Institut Pasteur, U604 INSERM, USC2020 INRA Paris, France
    Immunol Rev 240:160-84. 2011
    b>Listeria monocytogenes is an intracellular bacterium responsible for a disease characterized by several clinical features, such as septicemia, brain infection, abortion, and perinatal infection...
  46. ncbi Listeriolysin O: a phagosome-specific lysin
    Pamela Schnupf
    Graduate Group in Microbiology, University of California, Berkeley, CA 94720 3202, USA
    Microbes Infect 9:1176-87. 2007
    ..cytolysin family and a primary virulence factor of the gram-positive, facultative intracellular pathogen Listeria monocytogenes. During the intracellular life cycle of L...
  47. ncbi Intracellular antibody neutralizes Listeria growth
    B T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, MO 63110, USA
    Immunity 14:503-12. 2001
    ..that treatment of mice with a neutralizing mAb against listeriolysin O (LLO), the pore-forming toxin of Listeria monocytogenes, provided resistance to this intracellular bacterium...
  48. pmc Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
    Jianghong Wu
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Immunol 30:693-702. 2010
    Infection with Listeria monocytogenes can cause meningitis and septicemia in newborn, elderly, or immunocompromised individuals. Pregnant women are particularly susceptible to Listeria, leading to a potentially fatal infection...
  49. ncbi Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
    Human listeriosis is a potentially fatal foodborne infection caused by Listeria monocytogenes, an opportunistic psychrophile bacterium that is widespread in the environment...
  50. ncbi CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen
    Michael Neuenhahn
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    Immunity 25:619-30. 2006
    ..Here we analyzed the role of DCs during infection with Listeria monocytogenes by performing systemic in vivo depletion of these cells. We showed that CD8alpha(+) DCs were crucial for L...
  51. ncbi Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
    Bryce E Mansfield
    Department of Pathobiology, University of Washington, USA
    Cell Microbiol 5:901-11. 2003
    The facultative intracellular bacterial pathogen Listeria monocytogenes is capable of replicating within a broad range of host cell types and host species...
  52. pmc Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
    John Demian Sauer
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3202, USA
    Cell Host Microbe 7:412-9. 2010
    ..In a genetic screen to identify Listeria monocytogenes mutants that induced altered levels of host cell death, we identified a mutation in lmo2473 that caused ..
  53. ncbi Invasion of mammalian cells by Listeria monocytogenes: functional mimicry to subvert cellular functions
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Trends Cell Biol 13:23-31. 2003
    The bacterium Listeria monocytogenes has the unusual capacity to enter and to multiply in nonphagocytic cells...
  54. ncbi A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3
    Admar Verschoor
    Institute for Medical Microbiology, Immunology and Hygiene, and Focus Group, Clinical Cell Processing and Purification, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 12:1194-201. 2011
    ..In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L...
  55. pmc Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria
    Keith S Bahjat
    Earle A Chiles Research Institute, Robert W Franz Cancer Research Center, Providence Cancer Center, Portland, Oregon, United States of America
    PLoS Pathog 5:e1000568. 2009
    b>Listeria monocytogenes is a facultative intracellular pathogen capable of inducing a robust cell-mediated immune response to sub-lethal infection. The capacity of L...
  56. ncbi Entry of Listeria monocytogenes into hepatocytes requires expression of inIB, a surface protein of the internalin multigene family
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 16:251-61. 1995
    The intracellular bacterium Listeria monocytogenes can invade several types of normally non-phagocytic cells...
  57. pmc Listeriosis in human pregnancy: a systematic review
    Ronald F Lamont
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
    J Perinat Med 39:227-36. 2011
    ..Antibiotic treatment requires agents able to penetrate, distribute, and remain stable within host cells. Prolonged use of high-dose ampicillin can significantly improve neonatal outcome...
  58. pmc Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs
    Jody A Melton-Witt
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Infect Immun 80:720-32. 2012
    b>Listeria monocytogenes causes a serious food-borne disease due to its ability to spread from the intestine to other organs, a process that is poorly understood. In this study we used 20 signature-tagged wild-type clones of L...
  59. pmc Caenorhabditis elegans is a model host for Listeria monocytogenes
    Line E Thomsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University KVL, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Appl Environ Microbiol 72:1700-1. 2006
    Here we report that Caenorhabditis elegans nematodes fed Listeria monocytogenes die over the course of several days, as a consequence of an accumulation of bacteria in the worm intestine...
  60. pmc Universal stress proteins are important for oxidative and acid stress resistance and growth of Listeria monocytogenes EGD-e in vitro and in vivo
    Christa Seifart Gomes
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    PLoS ONE 6:e24965. 2011
    ..As part of this, the universal stress protein A (UspA) and its homologues, initially discovered in Escherichia coli K-12 were shown to possess an important role in stress resistance and growth in several bacterial species...
  61. ncbi The arsenal of virulence factors deployed by Listeria monocytogenes to promote its cell infection cycle
    Ana Camejo
    Group of Molecular Microbiology, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    Virulence 2:379-94. 2011
    b>Listeria monocytogenes is an intracellular Gram-positive pathogen and the etiological agent of listeriosis, a human food-borne disease potentially fatal for certain risk groups. The virulence of L...
  62. ncbi Molecular pathogenesis of Listeria monocytogenes in the alternative model host Galleria mellonella
    Susan A Joyce
    Department of Microbiology, University College Cork, Cork, Ireland
    Microbiology 156:3456-68. 2010
    ..In this study we show that inoculation with Listeria monocytogenes initiates a dynamic infection in G...
  63. pmc Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage
    Evgenia Solodova
    Department of Molecular Biotechnology, Helmholtz Centre for Infection Research, Brunswick, Germany
    PLoS ONE 6:e18543. 2011
    ..question which cells are responsible for IFN-β expression after infection with the intracellular pathogen Listeria monocytogenes by using a genetic approach...
  64. pmc Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo
    L M Mitchell
    Departments of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cell Immunol 268:79-86. 2011
    To determine the relative contributions of DC subsets in the development of protective immunity to Listeria monocytogenes we examined the relationship between maturation, bacterial burden, and T cell priming capacity of four well ..
  65. ncbi Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity
    Chelsea E Witte
    Graduate Group in Microbiology, University of California, Berkeley, Berkeley, California, USA
    Adv Immunol 113:135-56. 2012
    Acquired cell-mediated immunity to Listeria monocytogenes is induced by infection with live, replicating bacteria that grow in the host cell cytosol, whereas killed bacteria, or those trapped in a phagosome, fail to induce protective ..
  66. pmc Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin
    Lee M Shaughnessy
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Microbiol 9:1695-704. 2007
    Three proteins secreted by Listeria monocytogenes facilitate escape from macrophage vacuoles: the cholesterol-dependent cytolysin listeriolysin O (LLO), a phosphoinositide-specific phospholipase C (PI-PLC) and a broad-range phospholipase ..
  67. pmc The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophages
    Mobarak A Mraheil
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Nucleic Acids Res 39:4235-48. 2011
    ..Currently extensive information exists on the sRNAs of Listeria monocytogenes expressed during growth in extracellular environments...
  68. ncbi Molecular biology of surface colonization by Listeria monocytogenes: an additional facet of an opportunistic Gram-positive foodborne pathogen
    Sandra Renier
    INRA, UR454 Microbiology, F 63122 Saint Genes Champanelle, France
    Environ Microbiol 13:835-50. 2011
    The opportunistic and facultative intracellular pathogenic bacterium Listeria monocytogenes causes a rare but severe foodborne disease called listeriosis, the outcome of which can be fatal...
  69. ncbi Combined antimicrobial effect of nisin and a listeriophage against Listeria monocytogenes in broth but not in buffer or on raw beef
    G A Dykes
    AgResearch, Hamilton, New Zealand
    Int J Food Microbiol 73:71-81. 2002
    ..of nisin and listeriophage LH7, alone and in combination, on the growth and survival of two strains of Listeria monocytogenes in broth and two model food systems, with appropriate controls, was determined...
  70. pmc PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated Listeria monocytogenes
    Jared H Rowe
    Department of Pediatrics, Center for Infectious Disease and Microbiology Translational Research, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 180:7553-7. 2008
    Infection with attenuated Listeria monocytogenes (Lm) is a robust in vivo model for examining how Ag-specific T cells are primed, and subsequent challenge with virulent Lm allows for the protective effects of T cell priming to be ..
  71. ncbi Prevalence and concentration of verocytotoxigenic Escherichia coli, Salmonella enterica and Listeria monocytogenes in the beef production chain: a review
    J R Rhoades
    Laboratory of Food Microbiology and Hygiene, Department of Food Science and Technology, Faculty of Agriculture, Aristotle University of Thessaloniki, P O Box 265, Thessaloniki 54124, Greece
    Food Microbiol 26:357-76. 2009
    ..of three important pathogens, verocytotoxigenic Escherichia coli (VTEC), Salmonella enterica and Listeria monocytogenes, in cattle and beef from the farm to the final, ready-to-eat product...
  72. pmc Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy
    Laurent Dortet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS Pathog 7:e1002168. 2011
    ..Together these results reveal that MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles...
  73. pmc Identification of the agr locus of Listeria monocytogenes: role in bacterial virulence
    Nicolas Autret
    Inserm U 570, CHU Necker Enfants Malades, 75730 Paris Cedex 15, France
    Infect Immun 71:4463-71. 2003
    b>Listeria monocytogenes is a gram-positive facultative intracellular food-borne pathogen that can cause severe infections in humans and animals...
  74. pmc Enumeration of viable Listeria monocytogenes cells by real-time PCR with propidium monoazide and ethidium monoazide in the presence of dead cells
    Y Pan
    U S Department of Agriculture, Agricultural Research Service, and North Carolina Agricultural Research Service, Department of Microbiology, North Carolina State University, Raleigh, NC 27695 7624, USA
    Appl Environ Microbiol 73:8028-31. 2007
    Propidium monoazide (PMA) and ethidium monoazide were used for enumeration of viable Listeria monocytogenes cells in the presence of dead cells. PMA had no antimicrobial effect on L. monocytogenes...
  75. pmc Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model
    Ian R Monk
    Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, Western Road, Cork, Ireland
    BMC Microbiol 10:318. 2010
    Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts...
  76. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  77. ncbi Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell Microbiol 10:2208-22. 2008
    b>Listeria monocytogenes surface proteins internalin (Inl)A and InlB interact with the junctional protein E-cadherin and the hepatocyte growth factor (HGF) receptor Met, respectively, on the surface of epithelial cells to mediate bacterial ..
  78. ncbi Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
    D G Brockstedt
    Cerus Corporation, 2411 Stanwell Drive, Concord, California 94520, USA
    Nat Med 11:853-60. 2005
    ..Using the intracellular pathogen Listeria monocytogenes as a model platform, recombinant psoralen-inactivated Lm DeltauvrAB vaccines induced potent CD4(+) and CD8(..
  79. pmc Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes
    Jesper Sejrup Nielsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Nucleic Acids Res 38:907-19. 2010
    ..Here, we provide evidence for Hfq-dependent translational repression in the Gram-positive human pathogen Listeria monocytogenes, which is known to encode at least 50 sRNAs...
  80. pmc Enhanced synthesis of internalin A in aro mutants of Listeria monocytogenes indicates posttranscriptional control of the inlAB mRNA
    Jochen Stritzker
    Biocenter Microbiology, University of Wurzburg, Am Hubland, Wurzburg, Germany
    J Bacteriol 187:2836-45. 2005
    b>Listeria monocytogenes mutants with deletions in aroA, aroB, or aroE exhibited strong posttranscriptional upregulation of internalin A (InlA) and InlB synthesis, which resulted in a more-than-10-fold increase in InlA-mediated ..
  81. ncbi Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
    ..evidence that cytosolic DNA activates a potent type I interferon response to the invasive bacterium Listeria monocytogenes. The noninvasive Legionella pneumophila triggers an identical response through its type IV secretion ..
  82. pmc Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
    Alexander J Webb
    Department of Microbiology, Imperial College London, London, UK
    Mol Microbiol 74:299-314. 2009
    ..In Listeria monocytogenes this glycolipid is Gal-Glc-DAG or Gal-Ptd-6Glc-DAG. Using a bioinformatics approach, we have identified L...
  83. ncbi Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    Koichi S Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 307:731-4. 2005
    ..The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD...
  84. ncbi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
    ..monocytogenes was critically dependent on Nod1 and Nod2 when mice were previously stimulated with lipopolysaccharide or E. coli. Thus, Nod1 and Nod2 are important for microbial recognition and host defense after TLR stimulation...
  85. pmc IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver
    Satoru Hamada
    Molecular Microbiology Group, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    J Immunol 181:3456-63. 2008
    ..In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection...
  86. ncbi Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling
    Bo Huang
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    Cancer Res 67:4346-52. 2007
    ..b>Listeria monocytogenes (Lm) survives in the microenvironment of large but not small tumors, resulting in the promotion of tumor ..
  87. pmc Microtiter plate assay for assessment of Listeria monocytogenes biofilm formation
    D Djordjevic
    Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Appl Environ Microbiol 68:2950-8. 2002
    b>Listeria monocytogenes has the ability to form biofilms on food-processing surfaces, potentially leading to food product contamination...
  88. ncbi Listeria comet tails: the actin-based motility machinery at work
    Anja Lambrechts
    Department of Medical Protein Research, Flanders Institute for Biotechnology VIB, Albert Baertsoenkaai 3, B 9000 Ghent, Belgium
    Trends Cell Biol 18:220-7. 2008
    b>Listeria monocytogenes is a master of mimicry that uses the host cell actin system both to move within the cytoplasm of infected cells and for cell-to-cell spread...
  89. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  90. pmc Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
    Didier Cabanes
    Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC 2020, Paris, France
    EMBO J 24:2827-38. 2005
    By comparative genomics, we have identified a gene of the intracellular pathogen Listeria monocytogenes that encodes an LPXTG surface protein absent from nonpathogenic Listeria species...
  91. pmc Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    BMC Microbiol 8:20. 2008
    The opportunistic food-borne gram-positive pathogen Listeria monocytogenes can exist as a free-living microorganism in the environment and grow in the cytoplasm of vertebrate and invertebrate cells following infection...
  92. pmc Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes
    Rebecca Henry
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Cell Microbiol 8:107-19. 2006
    The bacterial pathogen Listeria monocytogenes (Lm) evades the antimicrobial mechanisms of macrophages by escaping from vacuoles to the cytosol, through the action of the cytolysin listeriolysin O (LLO)...
  93. ncbi Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination
    Vladimir P Badovinac
    Department of Microbiology, 3 512 Bowen Science Building, 51 Newton Road, University of Iowa, Iowa City, Iowa 52240, USA
    Nat Med 11:748-56. 2005
    ....
  94. pmc Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
    Sarah Kim
    Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 40:1545-51. 2010
    ..the recognition and containment of various microbial pathogens, including the intracellularly replicating Listeria monocytogenes; however, the inflammasome pathways activated during L. monocytogenes infection are only poorly defined...
  95. pmc High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Genomics 11:120. 2010
    ..A large, multi-province outbreak of listeriosis associated with ready-to-eat meat products contaminated with Listeria monocytogenes serotype 1/2a occurred in Canada in 2008...
  96. ncbi Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3
    Karolin Meixenberger
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 184:922-30. 2010
    ..b>Listeria monocytogenes is an intracellular pathogen that is actively phagocytosed by monocytes/macrophages and subsequently ..
  97. ncbi Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria species
    Matthias Trost
    Department of Cell Biology, German Research Centre for Biotechnology, GBF, Braunschweig, Germany
    Proteomics 5:1544-57. 2005
    ..we present the first comprehensive validation of the secretory subproteome of the Gram positive pathogen Listeria monocytogenes using predictive bioinformatic and experimental proteomic approaches...
  98. ncbi Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes
    Kohsuke Tsuchiya
    Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 185:1186-95. 2010
    b>Listeria monocytogenes invades the cytoplasm of macrophages and induces the activation of caspase-1 and the subsequent maturation of IL-1beta and IL-18...
  99. pmc CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
    Gabrielle T Belz
    Division of Immunology and Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 175:196-200. 2005
    ..to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8alpha(+) DCs are the principal DC ..
  100. pmc pbp2229-mediated nisin resistance mechanism in Listeria monocytogenes confers cross-protection to class IIa bacteriocins and affects virulence gene expression
    Anne Gravesen
    Department of Dairy and Food Science, Centre for Advanced Food Studies, LMC, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg C, Denmark
    Appl Environ Microbiol 70:1669-79. 2004
    ..Although the changes mostly were moderate, the consistency indicates that a mutant-specific change in virulence may occur concomitantly with bacteriocin resistance development...

Research Grants73

  1. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..Vibrio cholerae, Campylobacter jejuni, Helicobacter pylori, Listeria monocytogenes, Clostridium perfringens and C. difficile...
  2. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2009
    ..aeruginosa, (FosB) in Staphylococcus aureus and Bacillus anthracis, and (FosX) in Brucella melitensis, Listeria monocytogenes and Clostridium botulinum...
  3. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..Streptococcus pyogenes (Group A strep), vancomycin resistant enterococcus (VRE), Bacillus anthracis, Listeria monocytogenes and Clostridium difficile...
  4. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..toxins are synthesized by at least three other notorious human pathogens, including Staphylococcus aureus, Listeria monocytogenes, and Clostridium botulinum...
  5. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2013
    ..bacterium, Bacillus subtilis, but is also found in Staphylococcus aureus, Streptococcus pneumoniae, Listeria monocytogenes, and Bacillus anthracis...
  6. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..important human pathogens such as Staphylococcus aureus, Streptococcus pneumonia, Clostridium perfringens, Listeria monocytogenes, Bacillus anthracis, etc. PcrA was discovered in S...
  7. CT EIP Capacities ACA Grant
    TRACEY L WEEKS; Fiscal Year: 2011
    ..meningitidis, Listeria monocytogenes, Haemophilus influenzae). We are requesting funding for a ...
  8. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..In conventional dendritic cells (DCs), antigens from phagocytosed bacteria - such as Listeria monocytogenes - are processed and presented by major histocompatibility complex (MHC) class I (MHC-I) and class II (MHC-..
  9. Structure and Mechanism of SAM-responsive Riboswitches
    Robert T Batey; Fiscal Year: 2013
    ..survival or virulence are under riboswitch control in a number of medically important pathogens including Listeria monocytogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis making them of great ..
  10. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..data suggests that the TLR7 agonist, imiquimod, is an effective adjuvant to immunization with recombinant Listeria monocytogenes (rLM) expressing melanoma antigens...
  11. Molecular Mechanism of cell-cell spread of Listeria in polarized epithelial cells
    KEITH PATRICK IRETON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Listeria monocytogenes is a food-borne, intracellular pathogen that causes gastroenteritis, abortions, or meningitis with a high mortality rate...
  12. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Challenge of post-BMT recipients with Listeria monocytogenes, vesicular stomatitis virus or murine cytomegalovirus will be used to assess na[unreadable]ve and effector/..
  13. Dissecting the Function and Regulation of Stress-Induced SUMOylation
    ROBERT CHARLES AUGUSTINE; Fiscal Year: 2013
    ..In addition, several pathogenic bacteria (Listeria monocytogenes, Streptococcus pneumoniae) and viruses (human adenovirus, influenza virus) alter SIS, and this is ..
  14. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2013
    ..Although the three proteins we study, Bacillus thuringiensis PI-PLC, Listeria monocytogenes PI-PLC, and mammalian PLC41, share a common structural framework for the catalytic domain, their ..
  15. Listeria-Based Therapeutic Cancer Vaccine for Melanoma
    Dirk G Brockstedt; Fiscal Year: 2011
    ..One such example is the use of live-attenuated and killed strains of the intracellular bacterium Listeria monocytogenes (Lm)...
  16. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    b>Listeria monocytogenes is a major food-borne pathogen that is the cause of significant morbidity and mortality worldwide. It is also currently in clinical trials as an anti-cancer therapeutic agent...
  17. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..tb), Bacille Calmette Guirin (BCG) or Listeria monocytogenes result in increased pulmonary bacterial burden in rodents exposed to DEP...
  18. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..Recent data from intracellular pathogens (i.e. Mycobacterium tuberculosis, Listeria monocytogenes) and other fungi (i.e...
  19. Branched-chain fatty acids and membrane function in Listeria monocytogenes
    BRIAN JAMES WILKINSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Listeria monocytogenes is a foodborne bacterial pathogen with the ability to grow at refrigeration temperatures, and is thus a psychrotolerant organism...
  20. Structure and mechanism of CRISPR interference.
    Ailong Ke; Fiscal Year: 2013
    ..important human pathogens such as Campylobacter human jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis...
  21. Multiplexed Detection of Food and Waterborne Pathogens
    Francis Barany; Fiscal Year: 2011
    ..coli, Pathogenic Vibrio spp, and Listeria monocytogenes)...
  22. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Using infectious agents such as lymphocytic choriomeningitis virus and Listeria monocytogenes to infect mice we will probe the contribution of CD4+ T cells during the priming or vaccination stage and ..
  23. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    ..response to standardized antigens such as NP-OVA and KLH as well as to the Th1-dependent infectious agent, Listeria monocytogenes. Antibody production and Th2-dependent isotype switching will be determined by ELISA of serum samples and ..
  24. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..albicans, Escherichia coli, Staphylococcus epidermidis, Streptococcus pneumoniae, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Streptococcus agalactiae...
  25. Understanding of a Family of Bacterial Transcription Factors
    Hwan Youn; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The CRP homologs found in bacterial pathogens such as Pseudomonas aeruginosa and Listeria monocytogenes act as virulence factors. This proposal will systematically characterize three P...
  26. Temporal Requirements for Intracellular Pathogenesis
    Darren E Higgins; Fiscal Year: 2012
    Project Summary/Abstract Listeria monocytogenes (Lm) is a model intracellular bacterial pathogen that causes serious foodborne illness in pregnant women, the elderly, and immunocompromised individuals...
  27. REGULATION OF GLUTAMATE SYNTHESIS IN BACILLUS SUBTILIS
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2011
    ..that regulate these genes in Bacillus subtilis, a well studied model Gram-positive bacterium, and Listeria monocytogenes, a model intracellular pathogen whose metabolic regulation is relatively unexplored...
  28. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The gram positive bacillus Listeria monocytogenes causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration...
  29. Investigating the role of Bacillithiol in metal ion homeostasis and the reactive
    Pete Chandrangsu; Fiscal Year: 2013
    ..for a number of medically and biotechnologically important Gram-positive bacteria, such as Bacillus anthracis, Staphylococcus aureus, and Listeria monocytogenes, the information generated from these studies will be of general interest.
  30. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    ..We have proposed a novel model of intestinal invasion and colonization by the pathogen Listeria monocytogenes. We found that the tips of intestinal villi are a specialized site where the normal cell extrusion process ..
  31. Chronic alcohol abuse disrupts CD8+T cell function
    Annette J Schlueter; Fiscal Year: 2013
    ..primary response after inoculation with an attenuated strain of the intracellular pathogenic bacterium, Listeria monocytogenes. Additional findings include several subset alterations, reduced expression of the IL-2 receptor beta ..
  32. Role of fascin1 in dendritic cell-mediated immunity against listeria infection
    Shigeko Yamashiro; Fiscal Year: 2013
    ..is to determine in vivo roles of fascin1 in dendritic cell (DC)-based immunity against infection of Listeria monocytogenes (Lm)...
  33. Enhancing Pathogen-specific Memory CD8+ T cell Responses in Vivo
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ..to study the activation of memory CD8+ T cells in vivo in mice infected with the intracellular bacterium Listeria monocytogenes (Lm)...
  34. Role of the Listeria protein InlC and its host ligand Tuba in cell-cell spread
    KEITH PATRICK IRETON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Listeria monocytogenes is a food-borne, intracellular pathogen capable of causing gastroenteritis, meningitis, and abortions...
  35. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..have been linked to several microbial species, including Escherichia coli O157:H7, Salmonella species, Listeria monocytogenes, Shigella species, Cyclospora cayetanensis, Hepatitis A virus, and Norwalk-like virus...
  36. Molecular biology of TSST-1 and other superantigen toxins
    Richard P Novick; Fiscal Year: 2012
    ..aureus, and we have recently demonstrated natural SaPI transfer to Listeria monocytogenes, as well as to other staphylococcal species...
  37. LISTERIA HEMOLYSIN AND ESCAPE FROM A VACUOLE
    Daniel A Portnoy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Listeria monocytogenes is a facultative intracellular pathogen that provides an extremely amenable model for basic studies on host-pathogen interactions. Importantly, L...
  38. The Immune Pathogenesis of Prenatal Listeria monocytogenes Infection
    Sing Sing Way; Fiscal Year: 2013
    ..abstract_text> ..
  39. Cell Type-Specific Roles of TLR Signaling In Immune Responses
    Anthony L DeFranco; Fiscal Year: 2012
    ..Aim 1), induction of inflammation and restriction of growth of two gram-positive bacterial pathogens, Listeria monocytogenes and Staphylococcus aureus (Aim 2), and for promotion of antibody responses to protein antigens (Aim 3)...
  40. Connecticut Emerging Infections Program
    MATTHEW LEWIS CARTTER; Fiscal Year: 2011
    ..Cryptosporidium, Cyclospora, E. colt O157 and other Shiga-toxin producing E. coil, Listeria monocytogenes, Salmonella spp., Shigelta spp., Vibrio spp., and Yersinia spp...
  41. Actin-Based Motility of a Bacterial Pathogen
    Julie A Theriot; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Listeria monocytogenes is a ubiquitous Gram-positive bacterium that can cause serious food-borne infections in pregnant women, newborns and immunocompromised or older adults...
  42. Targeting host deubiquitinases for broad spectrum anti-infective therapy
    Christiane Wobus; Fiscal Year: 2013
    ..b>Listeria monocytogenes is another food-borne pathogen with a 20 - 25% fatality rate, responsible for recent cantaloupe-associated ..
  43. Role of CD11c in CD8 T cell response to infection
    Hector L Aguila; Fiscal Year: 2012
    ..identified a series of stepwise events that drive CD8 T cell activation in response to infection with Listeria monocytogenes. In situ analysis using confocal microscopy will be performed to assess the role of CD11c in activation ..
  44. Inhibition of T cell Responses by Bacteria
    Michael N Starnbach; Fiscal Year: 2010
    ..During infection with Listeria monocytogenes, another intracellular bacterial pathogen that escapes into the host cell cytosol, Listeria-derived ..
  45. Inducible Renitence in Macrophages
    Joel A Swanson; Fiscal Year: 2013
    ..the role of renitence in macrophage resistance to infection by the Gram-positive intracellular pathogen Listeria monocytogenes, which normally scapes into cytoplasm by damaging vacuolar membranes...
  46. Immunizing Against Malaria by Inducing Both Protective Antibodies and CD8 T Cells
    B Kim Lee Sim; Fiscal Year: 2013
    ..Recently, it was shown in mice that recombinant attenuated Listeria monocytogenes (Lm) induced much higher quality (functional) CD8+ T cell responses than did recombinant Ad5...
  47. Regulation of monocyte recruitment and function by the IL-23/IL-17 axis
    Rance E Berg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Listeria monocytogenes (LM) is an intracellular bacterium that can cause spontaneous abortions in pregnant women and can lead to septicemia and meningitis in immunocompromised individuals...
  48. CC-chemokines in Listeria infection.
    Eric G Pamer; Fiscal Year: 2013
    ..receptor and its ligands MCP1 and MCP3 are required for monocyte emigration from the bone marrow during Listeria monocytogenes infection...
  49. MHC-Ib restricted T cell responses against Listeria monocytogenes
    SARAH E F D apos ORAZIO; Fiscal Year: 2010
    1 Listeria monocytogenes (Lm) is a category B priority pathogen that causes outbreaks of 2 foodborne illness with a high incidence of morbidity and mortality...
  50. Host factors involved in Listeria monocytogenes spread from cell to cell
    HERVE F AGAISSE; Fiscal Year: 2010
    ..Genetic and biochemical studies revealed that Listeria monocytogenes actin-based motility relies on the expression of ActA, a bacterial factor that recruits the ARP2/3 complex ..
  51. Intracellular Bacterial Recognition in the Drosophila Innate Immune Response
    Neal Silverman; Fiscal Year: 2012
    ..In addition to small fragments of peptidoglycan, PGRP-LE also recognizes cytosolic bacteria, like Listeria monocytogenes, and this recognition is critical to block bacterial growth...
  52. Selective Delivery of a novel bacterial adjuvant for multipurpose vaccination
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ..Mice immunized with the intracellular bacterium Listeria monocytogenes (Lm) develop life-long immunity against a challenge infection by Lm...
  53. Development of Novel Antimicrobial Peptide Mimics
    Paul B Savage; Fiscal Year: 2011
    ..The ceragenins are also active against the following organisms: E. coli, Vibrios, Salmonella, Listeria monocytogenes, Campylobacteria jejuni and Yersinia enterocolitica (all Category B Pathogens)...
  54. Discovering mechanisms of bacterial cell division: From genotype to phenotype
    Jen Hsin; Fiscal Year: 2012
    ..provided by applicant): The recent outbreaks of bacterial infections caused by Escherichia coli and Listeria monocytogenes mark the critical importance in the search of new lines of antibiotics...
  55. IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Laurel L Lenz; Fiscal Year: 2013
    ..The category A intracellular bacterial pathogen Francisella tularensis, the category B bacterium Listeria monocytogenes, Mycobacterium tuberculosis, and numerous other important human intracellular pathogens have evolved to ..
  56. Live Oral Listeria Vaccine Vector
    PAUL EDWIN ORNDORFF; Fiscal Year: 2010
    ..is to explore the feasibility of using bacteriophage resistance as a feature of a live, attenuated, oral Listeria monocytogenes vaccine delivery platform...
  57. Engineered Listeria monocytogenes as an AIDS vaccine
    Judy Lieberman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Listeria monocytogenes (Lm) is an attractive bacterial vector to elicit T cell immunity to HIV because it specifically infects key antigen presenting cells (APCs) and because natural infection ..
  58. IMPDH-targeted antibiotics for select agents
    LIZBETH K HEDSTROM; Fiscal Year: 2013
    ..Bacillus anthracis (Gram positive), Francisella tularensis (Gram-negative facultative intracellular), Listeria monocytogenes (Gram- positive facultative intracellular), Burkholderia mallei/pseudomallei (Gram-negative facultative ..
  59. BcI-2 family in T lymphocyte homeostasis
    You Wen He; Fiscal Year: 2013
    ..molecules in regulating the survival of naive, effector, and memory T lymphocytes in vivo using Listeria monocytogenes infection model. Our overall hypothesis is that Bcl-2 and Mcl-1 differentially regulate T cell survival...
  60. Modulation of Biodefense Responses to Microbial Pathogens
    Anthony T Vella; Fiscal Year: 2013
    ..proposes to investigate the mechanisms regulating the intestinal mucosal T cell response to oral Listeria monocytogenes infection (LM). A novel system that mimics human infection will be employed...
  61. SLAT: A novel GEF coordinating actin remodeling and Ca2+ signaling in T cells
    Amnon Altman; Fiscal Year: 2013
    ..a role for SLAT in CD8+ T cell activation and expansion to study whether SLAT is required for pathogen (Listeria Monocytogenes and Vaccinia virus) clearance, and whether the Ca2+ signaling defect is the cause of impaired CD8+ T cell ..
  62. Immune responses to infection at the maternal-fetal interface
    Gabrielle A Rizzuto; Fiscal Year: 2013
    ..We will study the placental innate immune responses to the facultative intracellular bacterial pathogen Listeria monocytogenes (LM)...
  63. S. typhimiurium Vaccine Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2007
    ..species, and less closely related enteropathogens such as Vibrio cholerae, Campylobacter jejuni and Listeria monocytogenes. In addition, these bacteria are responsible are responsible for significant morbidity causing diarrheal ..
  64. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2003
    ..increase the efficacy of antibiotics against Mycobacterium, Avium complex, Legionella pneumophila, and Listeria monocytogenes, in human monocytes and macrophage to identify the transporter molecule by expression cloning, and to ..
  65. Molecular Mechanisms of L. monocytogenes Adhesion Through Surface Biopolymers
    NEHAL IBRAHIM ABU LAIL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Our ability to explain and control the adhesion of Listeria monocytogenes to surfaces is limited by the lack of molecular-scale studies on how the surface biopolymers of L...
  66. Escape of Bacillus anthracis from the phagsome
    Howard Goldfine; Fiscal Year: 2004
    ..replicate in the cytosol, a process that was first described and best studied in another human pathogen Listeria monocytogenes (Lm)...
  67. Listeria Immunotherapy for Pancreatic and Ovarian Cancer
    Thomas Dubensky; Fiscal Year: 2006
    ..S. The overall goal of this SBIR phase II proposal is to continue development of our Listeria monocytogenes (Lm)-based immunotherapy to target Mesothelin and codon 12-mutated activated K-ras antigens in patients ..
  68. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector...
  69. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
    ..on InIB, a 67 kDa invasion protein produced by the Gram-positive, facultative intracellular pathogen Listeria monocytogenes, a cause of meningitis, abortion, gastroenteritis, and septicemia in humans...
  70. DELIVERY OF PROTEINS INTO CYTOSOL USING LLO-LIPOSOMES
    Kyung Dall Lee; Fiscal Year: 2002
    ..e., to take a minimal component from a facultative intracellular bacterium, Listeria monocytogenes, and construct a liposome-based cytosolic delivery vehicle...
  71. LISTERIA MONOCYTOGENES AND PHAGOSOME MEMBRANE TRAFFIC
    Philip Stahl; Fiscal Year: 2003
    A wide variety of human pathogens including Listeria monocytogenes (LM) take up residence and thrive within host cells by interfering with membrane trafficking events...
  72. ROLE OF CYTOKINE METABOLISM IN OZONE IMMUNOTOXICITY
    Judith Zelikoff; Fiscal Year: 2001
    ..early and late stages of PAM activation during the course of a CMI reaction against a bacterial pathogen, Listeria monocytogenes. The animal model to be used is the Fisher 344 rat, and in vivo and in vitro exposure regimens will be ..
  73. Role of Adapter Protein in Infectious Diseases
    Maria Diakonova; Fiscal Year: 2005
    b>Listeria monocytogenes is a food-borne pathogen that can cause meningitis, meningoencephalitis, septicemias, abortions and, in some cases, gastroenteritis...